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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pregnenolone
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Accession:CHEBI:16581 term browser browse the term
Definition:A 20-oxo steroid that is pregn-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 20.
Synonyms:related_synonym: (3BETA)-3-HYDROXYPREGN-5-EN-20-ONE;   3beta-Hydroxypregn-5-en-20-one;   5-Pregnen-3beta-ol-20-one;   Formula=C21H32O2;   InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1;   InChIKey=ORNBQBCIOKFOEO-QGVNFLHTSA-N;   SMILES=[H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@H](CC[C@@]21[H])C(C)=O
 alt_id: CHEBI:14881;   CHEBI:26241;   CHEBI:45027;   CHEBI:8388;   CHEBI:86573
 xref: Beilstein:2059026;   CAS:145-13-1;   DrugBank:DB02789;   HMDB:HMDB0000253;   KEGG:C01953;   KEGG:D00143;   LINCS:LSM-5550;   LIPID_MAPS_instance:LMST02030088
 xref_mesh: MESH:D011284
 xref: PDBeChem:PLO;   PMID:23572091;   PMID:24385629;   Reaxys:2059026;   Wikipedia:Pregnenolone

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pregnenolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor decreases activity ISO Pregnenolone results in decreased activity of AHR protein CTD PMID:30203046 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G App amyloid beta precursor protein decreases response to substance EXP Pregnenolone results in decreased susceptibility to APP protein modified form CTD PMID:18926803 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions EXP Pregnenolone inhibits the reaction [Acetylcholine binds to CHRM1 protein]; Pregnenolone inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM1 protein] CTD PMID:15900516 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions EXP Pregnenolone inhibits the reaction [Acetylcholine binds to CHRM3 protein]; Pregnenolone inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM3 protein] CTD PMID:15900516 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases chemical synthesis
multiple interactions		 ISO
EXP		 CYP11A1 protein results in increased chemical synthesis of Pregnenolone
[Diethylstilbestrol results in decreased expression of CYP11A1 protein] which results in decreased chemical synthesis of Pregnenolone		 CTD PMID:16054388, PMID:19900470, PMID:23873838 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 affects metabolic processing
increases hydroxylation
multiple interactions		 ISO
EXP		 CYP17A1 protein affects the metabolism of Pregnenolone
CYP17A1 protein mutant form results in increased hydroxylation of Pregnenolone; CYP17A1 protein results in increased hydroxylation of Pregnenolone
[[abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone; [abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Pregnenolone; [CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone]; Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased hydroxylation of Pregnenolone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone]; Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased hydroxylation of Pregnenolone]
Plant Extracts inhibits the reaction [Pregnenolone binds to CYP17A1 protein]		 CTD PMID:15562394, PMID:15666820, PMID:15844475, PMID:16030167, PMID:16054388, PMID:17194026, PMID:29100959 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases activity EXP Pregnenolone results in decreased activity of CYP7A1 protein CTD PMID:1175606 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Fgf9 fibroblast growth factor 9 multiple interactions ISO FGF9 protein inhibits the reaction [[FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone] CTD PMID:22798350 NCBI chr15:38,341,657...38,386,945
Ensembl chr15:38,341,089...38,387,316 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO [FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone; FGF9 protein inhibits the reaction [[FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone] CTD PMID:22798350 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP Pregnenolone results in increased expression of GSTA2 mRNA CTD PMID:11502894 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO Pregnenolone inhibits the reaction [25-hydroxycholesterol results in decreased activity of HMGCR protein]; Pregnenolone inhibits the reaction [27-hydroxycholesterol results in decreased activity of HMGCR protein] CTD PMID:9059514 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 increases expression ISO Pregnenolone results in increased expression of HSD17B1 mRNA CTD PMID:20956811 NCBI chr10:88,987,558...88,989,758
Ensembl chr10:88,987,558...88,989,757 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 affects metabolic processing
increases metabolic processing
multiple interactions		 ISO HSD3B1 protein affects the metabolism of Pregnenolone
HSD3B2 protein results in increased metabolism of Pregnenolone
[HSD3B2 protein results in increased metabolism of Pregnenolone] which results in increased abundance of Progesterone		 CTD PMID:16054388, PMID:21558439
G Igf1 insulin-like growth factor 1 multiple interactions ISO [FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone; FGF9 protein inhibits the reaction [[FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone] CTD PMID:22798350 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions
increases abundance		 EXP 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine inhibits the reaction [LHB protein results in increased abundance of Pregnenolone]; 5,8,11,14-Eicosatetraynoic Acid inhibits the reaction [LHB protein results in increased abundance of Pregnenolone]; benoxaprofen inhibits the reaction [LHB protein results in increased abundance of Pregnenolone]; Masoprocol inhibits the reaction [LHB protein results in increased abundance of Pregnenolone] CTD PMID:6430271 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO Pregnenolone results in increased activity of NFE2L2 protein CTD PMID:30203046 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity		 ISO Pregnenolone binds to and results in increased activity of NR1I2 protein
Pregnenolone results in increased activity of NR1I2 protein		 CTD PMID:15650019, PMID:16054614 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Pregnenolone results in increased activity of NR1I3 protein CTD PMID:30203046 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 increases abundance ISO SIGMAR1 protein results in increased abundance of Pregnenolone CTD PMID:22923735 NCBI chr 5:58,121,824...58,124,687
Ensembl chr 5:58,121,786...58,124,681 		JBrowse link
17alpha-hydroxypregnenolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 affects chemical synthesis
increases metabolic processing
multiple interactions
affects metabolic processing
decreases acetylation		 ISO CYP17A1 protein affects the chemical synthesis of 17-alpha-Hydroxypregnenolone
CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone
[[abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone; [CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone; [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone]; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]; Duloxetine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]; Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone]
CYP17A1 protein affects the metabolism of 17-alpha-Hydroxypregnenolone
CYP17A1 protein results in decreased acetylation of 17-alpha-Hydroxypregnenolone		 CTD PMID:15562394, PMID:16030167, PMID:17194026, PMID:29100959 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239 		JBrowse link
pregnenolone 16alpha-carbonitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aacs acetoacetyl-CoA synthetase increases expression
decreases expression
multiple interactions		 ISO Pregnenolone Carbonitrile results in increased expression of AACS mRNA
Pregnenolone Carbonitrile results in decreased expression of AACS mRNA
NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of AACS mRNA]		 CTD PMID:22698814, PMID:28903501 NCBI chr12:36,512,393...36,555,694
Ensembl chr12:36,512,393...36,555,694 		JBrowse link
G Aadac arylacetamide deacetylase decreases expression
multiple interactions		 ISO Pregnenolone Carbonitrile results in decreased expression of AADAC mRNA
NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in decreased expression of AADAC mRNA]		 CTD PMID:22429928, PMID:28903501 NCBI chr 2:150,146,234...150,157,480
Ensembl chr 2:150,146,234...150,157,480 		JBrowse link
G Aadat aminoadipate aminotransferase decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of AADAT mRNA CTD PMID:19162173 NCBI chr16:32,832,001...32,868,680
Ensembl chr16:32,832,061...32,868,702 		JBrowse link
G Aass aminoadipate-semialdehyde synthase increases expression ISO Pregnenolone Carbonitrile results in increased expression of AASS mRNA CTD PMID:28903501 NCBI chr 4:50,152,005...50,208,935
Ensembl chr 4:50,152,452...50,200,328 		JBrowse link
G Abat 4-aminobutyrate aminotransferase decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ABAT mRNA CTD PMID:19162173 NCBI chr10:7,093,406...7,200,439
Ensembl chr10:7,093,405...7,200,499 		JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ABCA1 mRNA; Pregnenolone Carbonitrile results in decreased expression of ABCA1 protein CTD PMID:15883047 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
increases expression		 ISO Endotoxins inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB11 mRNA] CTD PMID:15456840 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression		 ISO
EXP		 Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 protein]; NR1I2 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 mRNA]; NR1I2 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 protein]
Pregnenolone Carbonitrile results in increased expression of ABCB1A mRNA
Pregnenolone Carbonitrile results in increased expression of ABCB1 mRNA; Pregnenolone Carbonitrile results in increased expression of ABCB1 protein; Pregnenolone Carbonitrile results in increased expression of ABCB1A mRNA		 CTD PMID:15456840, PMID:16819505, PMID:19162173, PMID:29863087 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression ISO Pregnenolone Carbonitrile results in increased expression of ABCB1B mRNA CTD PMID:29863087 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression
decreases expression		 EXP
ISO		 Pregnenolone Carbonitrile results in increased expression of ABCB4 mRNA
Pregnenolone Carbonitrile results in decreased expression of ABCB4 mRNA		 CTD PMID:19162173, PMID:28903501 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 multiple interactions ISO ABCB6 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A11 mRNA] CTD PMID:25623066 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of ABCC1 mRNA CTD PMID:11752103 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression		 ISO
EXP		 [Pregnenolone Carbonitrile co-treated with NR1I2 protein mutant form] results in increased expression of ABCC2 mRNA; Endotoxins inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCC2 mRNA]
Pregnenolone Carbonitrile results in increased expression of ABCC2 mRNA; Pregnenolone Carbonitrile results in increased expression of ABCC2 protein		 CTD PMID:15456840, PMID:15917434, PMID:19118567, PMID:19162173, PMID:20888898, PMID:21318169, PMID:22496397, PMID:22659317 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases expression
increases activity		 ISO
EXP		 [Pregnenolone Carbonitrile binds to NR1I2 protein] which results in increased expression of ABCC3 mRNA; [Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to ABCC3 gene]] which results in increased expression of ABCC3 mRNA; [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of ABCC3 mRNA]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to ABCC3 gene]
Pregnenolone Carbonitrile results in increased expression of ABCC3 mRNA; Pregnenolone Carbonitrile results in increased expression of ABCC3 protein
Pregnenolone Carbonitrile results in increased activity of ABCC3 protein		 CTD PMID:14570758, PMID:15456840, PMID:15833929, PMID:15986414, PMID:19162173, PMID:20693526, PMID:22496397, PMID:27413110, PMID:28903501 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 affects expression ISO Pregnenolone Carbonitrile affects the expression of ABCC4 mRNA CTD PMID:31388680 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592 		JBrowse link
G Abcd4 ATP binding cassette subfamily D member 4 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ABCD4 mRNA CTD PMID:28903501 NCBI chr 6:108,315,026...108,329,550
Ensembl chr 6:108,315,035...108,329,464 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression
multiple interactions		 EXP
ISO		 Pregnenolone Carbonitrile results in increased expression of ABCG5 mRNA
[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in increased expression of ABCG5 mRNA		 CTD PMID:15683829, PMID:20359477 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression EXP Pregnenolone Carbonitrile results in increased expression of ABCG8 mRNA CTD PMID:15683829 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708 		JBrowse link
G Abhd14b abhydrolase domain containing 14b decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ABHD14B mRNA CTD PMID:28903501 NCBI chr 8:115,149,638...115,154,556
Ensembl chr 8:115,150,514...115,154,550 		JBrowse link
G Abhd17b abhydrolase domain containing 17B, depalmitoylase increases expression ISO Pregnenolone Carbonitrile results in increased expression of ABHD17B mRNA CTD PMID:22698814 NCBI chr 1:239,266,140...239,301,133
Ensembl chr 1:239,266,921...239,301,176 		JBrowse link
G Ablim1 actin-binding LIM protein 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ABLIM1 mRNA CTD PMID:28903501 NCBI chr 1:277,853,877...278,043,096 JBrowse link
G Ablim3 actin binding LIM protein family, member 3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ABLIM3 mRNA CTD PMID:28903501 NCBI chr18:57,126,534...57,245,965
Ensembl chr18:57,128,399...57,245,666 		JBrowse link
G Abtb2 ankyrin repeat and BTB domain containing 2 increases expression
decreases expression		 EXP
ISO		 Pregnenolone Carbonitrile results in increased expression of ABTB2 mRNA
Pregnenolone Carbonitrile results in decreased expression of ABTB2 mRNA		 CTD PMID:19162173, PMID:28903501 NCBI chr 3:93,494,706...93,648,750
Ensembl chr 3:93,495,106...93,647,721 		JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ACAA1B mRNA CTD PMID:28903501 NCBI chr 8:127,836,235...127,845,296 JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 increases expression EXP Pregnenolone Carbonitrile results in increased expression of ACAA2 mRNA CTD PMID:19162173 NCBI chr18:70,733,872...70,762,395
Ensembl chr18:70,733,872...70,762,395 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of ACACA mRNA] CTD PMID:20359477 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910 		JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ACAT1 mRNA CTD PMID:19162173 NCBI chr 8:58,166,990...58,195,884
Ensembl chr 8:58,166,990...58,195,884 		JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 decreases expression EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of ACAT2 mRNA CTD PMID:19162173, PMID:28903501 NCBI chr 1:47,972,399...47,992,654
Ensembl chr 1:47,972,399...47,992,653 		JBrowse link
G Acbd4 acyl-CoA binding domain containing 4 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ACBD4 mRNA CTD PMID:28903501 NCBI chr10:91,186,131...91,200,081
Ensembl chr10:91,187,593...91,196,572 		JBrowse link
G Acbd5 acyl-CoA binding domain containing 5 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ACBD5 mRNA CTD PMID:28903501 NCBI chr17:89,882,465...89,923,982
Ensembl chr17:89,883,615...89,923,423 		JBrowse link
G Acer2 alkaline ceramidase 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ACER2 mRNA CTD PMID:28903501 NCBI chr 5:105,230,540...105,279,732
Ensembl chr 5:105,230,580...105,279,731 		JBrowse link
G Acly ATP citrate lyase decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ACLY mRNA CTD PMID:19162173 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845 		JBrowse link
G Aco2 aconitase 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ACO2 mRNA CTD PMID:28903501 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635 		JBrowse link
G Acod1 aconitate decarboxylase 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ACOD1 mRNA CTD PMID:22698814 NCBI chr15:93,612,968...93,622,322
Ensembl chr15:93,612,971...93,622,358 		JBrowse link
G Acot1 acyl-CoA thioesterase 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ACOT1 mRNA CTD PMID:19162173 NCBI chr 6:107,485,088...107,493,082
Ensembl chr 6:107,485,249...107,493,798 		JBrowse link
G Acot2 acyl-CoA thioesterase 2 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ACOT2 mRNA CTD PMID:19162173 NCBI chr 6:107,460,596...107,468,324
Ensembl chr 6:107,460,668...107,467,487 		JBrowse link
G Acot3 acyl-CoA thioesterase 3 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ACOT3 mRNA CTD PMID:27413110 NCBI chr 6:107,531,508...107,537,446
Ensembl chr 6:107,531,528...107,536,789 		JBrowse link
G Acot4 acyl-CoA thioesterase 4 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ACOT4 mRNA CTD PMID:28903501 NCBI chr 6:107,517,668...107,522,952
Ensembl chr 6:107,517,668...107,522,952 		JBrowse link
G Acot6 acyl-CoA thioesterase 6 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ACOT6 mRNA CTD PMID:22698814 NCBI chr 6:107,581,357...107,590,431
Ensembl chr 6:107,581,608...107,590,373 		JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ACOX1 mRNA CTD PMID:28903501 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050 		JBrowse link
G Acox2 acyl-CoA oxidase 2 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ACOX2 mRNA CTD PMID:19162173 NCBI chr15:18,449,304...18,481,472
Ensembl chr15:18,451,144...18,481,470 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression
multiple interactions		 EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of ACSL1 mRNA
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of ACSL1 mRNA]		 CTD PMID:19162173, PMID:20359477 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ACSL4 mRNA CTD PMID:28903501 NCBI chr  X:113,596,247...113,660,024
Ensembl chr  X:113,596,239...113,659,944 		JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ACSL5 mRNA CTD PMID:28903501 NCBI chr 1:276,240,703...276,290,012
Ensembl chr 1:276,240,703...276,290,008 		JBrowse link
G Acsm2 acyl-CoA synthetase medium-chain family member 2 decreases expression
increases expression		 EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of ACSM2A mRNA
Pregnenolone Carbonitrile results in increased expression of ACSM2 mRNA		 CTD PMID:19162173, PMID:22698814 NCBI chr 1:189,289,957...189,329,007
Ensembl chr 1:189,289,957...189,395,276 		JBrowse link
G Acsm3 acyl-CoA synthetase medium-chain family member 3 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ACSM3 mRNA CTD PMID:19162173 NCBI chr 1:189,514,504...189,541,233
Ensembl chr 1:189,514,553...189,541,224 		JBrowse link
G Acsm5 acyl-CoA synthetase medium-chain family member 5 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ACSM5 mRNA CTD PMID:28903501 NCBI chr 1:189,240,955...189,270,422
Ensembl chr 1:189,233,141...189,272,172 		JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ACSS2 mRNA CTD PMID:28903501 NCBI chr 3:151,032,925...151,075,856
Ensembl chr 3:151,032,952...151,075,856 		JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression ISO Pregnenolone Carbonitrile results in increased expression of ACTA2 mRNA CTD PMID:28903501 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394 		JBrowse link
G Actg1 actin, gamma 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of ACTG1 mRNA CTD PMID:19162173 NCBI chr10:109,518,429...109,521,288
Ensembl chr 3:75,643,054...75,644,954
Ensembl chr10:75,643,054...75,644,954 		JBrowse link
G Acy3 aminoacylase 3 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ACY3 mRNA CTD PMID:28903501 NCBI chr 1:219,233,712...219,237,103
Ensembl chr 1:219,233,750...219,237,098 		JBrowse link
G Adamts14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ADAMTS14 mRNA CTD PMID:28903501 NCBI chr20:30,812,319...30,888,936
Ensembl chr20:30,812,353...30,888,751 		JBrowse link
G Adamts15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ADAMTS15 mRNA CTD PMID:28903501 NCBI chr 8:31,977,001...32,000,378
Ensembl chr 8:31,977,001...32,000,378 		JBrowse link
G Adamtsl2 ADAMTS-like 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ADAMTSL2 mRNA CTD PMID:28903501 NCBI chr 3:5,624,473...5,654,890
Ensembl chr 3:5,624,506...5,654,910 		JBrowse link
G Adarb1 adenosine deaminase, RNA-specific, B1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ADARB1 mRNA CTD PMID:28903501 NCBI chr20:11,972,352...12,101,022
Ensembl chr20:11,972,381...12,101,047 		JBrowse link
G Adck5 aarF domain containing kinase 5 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ADCK5 mRNA CTD PMID:28903501 NCBI chr 7:117,643,976...117,661,789
Ensembl chr 7:117,643,206...117,661,845 		JBrowse link
G Adcy1 adenylate cyclase 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ADCY1 mRNA CTD PMID:28903501 NCBI chr14:87,311,970...87,429,880
Ensembl chr14:87,312,203...87,421,659 		JBrowse link
G Add1 adducin 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of ADD1 mRNA CTD PMID:19162173 NCBI chr14:81,367,466...81,426,610
Ensembl chr14:81,367,468...81,426,496 		JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) decreases expression EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of ADH1 mRNA CTD PMID:19162173, PMID:28903501 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857 		JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ADH4 mRNA CTD PMID:28903501 NCBI chr 2:243,702,035...243,720,063
Ensembl chr 2:243,700,784...243,740,899 		JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ADH7 mRNA CTD PMID:28903501 NCBI chr 2:243,500,540...243,516,865
Ensembl chr 2:243,502,073...243,516,532 		JBrowse link
G Adhfe1 alcohol dehydrogenase, iron containing, 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ADHFE1 mRNA CTD PMID:27413110 NCBI chr 5:9,403,194...9,429,783
Ensembl chr 5:9,403,196...9,429,859 		JBrowse link
G Adrb3 adrenoceptor beta 3 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ADRB3 mRNA CTD PMID:28903501 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632 		JBrowse link
G Aen apoptosis enhancing nuclease increases expression ISO Pregnenolone Carbonitrile results in increased expression of AEN mRNA CTD PMID:28903501 NCBI chr 1:140,584,328...140,593,749
Ensembl chr 1:140,584,380...140,593,745 		JBrowse link
G Afm afamin decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of AFM mRNA CTD PMID:28903501 NCBI chr14:19,078,678...19,132,212
Ensembl chr14:19,078,680...19,132,208 		JBrowse link
G Afp alpha-fetoprotein decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of AFP mRNA CTD PMID:27413110, PMID:28903501 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923 		JBrowse link
G Ager advanced glycosylation end product-specific receptor decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of AGER mRNA CTD PMID:19162173 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079 		JBrowse link
G Ago1 argonaute RISC component 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of AGO1 mRNA CTD PMID:22698814 NCBI chr 5:144,444,390...144,479,430
Ensembl chr 5:144,448,792...144,479,306 		JBrowse link
G Agxt alanine--glyoxylate and serine--pyruvate aminotransferase decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of AGXT mRNA CTD PMID:19162173 NCBI chr 9:100,281,339...100,291,292
Ensembl chr 9:100,281,339...100,291,291 		JBrowse link
G Ahcy adenosylhomocysteinase increases expression ISO Pregnenolone Carbonitrile results in increased expression of AHCY mRNA CTD PMID:28903501 NCBI chr 3:150,587,833...150,603,057
Ensembl chr 3:150,587,833...150,603,082 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein inhibits the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA]]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR mRNA]] CTD PMID:28428138 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Aif1 allograft inflammatory factor 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of AIF1 mRNA CTD PMID:19162173 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448 		JBrowse link
G Aifm2 apoptosis inducing factor, mitochondria associated 2 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of AIFM2 mRNA CTD PMID:19162173 NCBI chr20:31,329,047...31,353,548
Ensembl chr20:31,339,787...31,352,906 		JBrowse link
G Aifm3 apoptosis inducing factor, mitochondria associated 3 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of AIFM3 mRNA CTD PMID:28903501 NCBI chr11:87,364,452...87,380,705
Ensembl chr11:87,366,621...87,380,704 		JBrowse link
G Akap17a A-kinase anchoring protein 17A decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of AKAP17B mRNA CTD PMID:28903501 NCBI chr12:18,527,116...18,531,780
Ensembl chr12:18,526,422...18,531,161 		JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 increases expression
multiple interactions		 ISO Pregnenolone Carbonitrile results in increased expression of AKR1B7 mRNA
NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of AKR1B7 mRNA]		 CTD PMID:25949234, PMID:27413110, PMID:28903501 NCBI chr 4:61,850,256...61,879,733
Ensembl chr 4:61,850,348...61,862,526 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of AKR1C6 mRNA CTD PMID:28903501 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321 		JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of AKR1D1 mRNA CTD PMID:28903501 NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941 		JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP Pregnenolone Carbonitrile results in increased expression of AKR7A3 mRNA CTD PMID:19162173 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756 		JBrowse link
G Alas1 5'-aminolevulinate synthase 1 increases expression EXP
ISO		 Pregnenolone Carbonitrile results in increased expression of ALAS1 mRNA CTD PMID:19162173, PMID:28903501 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression
multiple interactions		 EXP
ISO		 Pregnenolone Carbonitrile results in increased expression of ALDH1A1 mRNA
[Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to ALDH1A1 intron]] which results in increased expression of ALDH1A1 mRNA; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of ALDH1A1 mRNA]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to ALDH1A1 intron]		 CTD PMID:17998271, PMID:19162173, PMID:20693526, PMID:22496397 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330 		JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ALDH1B1 mRNA CTD PMID:17998271 NCBI chr 5:61,382,351...61,387,359
Ensembl chr 5:61,382,351...61,387,358 		JBrowse link
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 increases expression
decreases expression		 EXP
ISO		 Pregnenolone Carbonitrile results in increased expression of ALDH1L1 mRNA
Pregnenolone Carbonitrile results in decreased expression of ALDH1L1 mRNA		 CTD PMID:19162173, PMID:27413110 NCBI chr 4:123,516,553...123,564,067
Ensembl chr 4:123,516,788...123,557,501 		JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ALDH3A2 mRNA CTD PMID:28903501 NCBI chr10:47,525,486...47,546,535
Ensembl chr10:47,525,493...47,546,345 		JBrowse link
G Aldh4a1 aldehyde dehydrogenase 4 family, member A1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ALDH4A1 mRNA CTD PMID:28903501 NCBI chr 5:158,090,238...158,115,725
Ensembl chr 5:158,042,587...158,135,733 		JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ALDH6A1 mRNA CTD PMID:27413110 NCBI chr 6:108,146,552...108,167,185
Ensembl chr 6:108,146,582...108,167,185 		JBrowse link
G Aldh8a1 aldehyde dehydrogenase 8 family, member A1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ALDH8A1 mRNA CTD PMID:17998271 NCBI chr 1:16,910,043...16,929,465
Ensembl chr 1:16,910,069...16,930,481 		JBrowse link
G Aldob aldolase, fructose-bisphosphate B increases expression ISO Pregnenolone Carbonitrile results in increased expression of ALDOB mRNA CTD PMID:22698814 NCBI chr 5:64,805,772...64,818,813
Ensembl chr 5:64,805,773...64,818,824 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ALOX5 mRNA CTD PMID:22698814 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303 		JBrowse link
G Amacr alpha-methylacyl-CoA racemase decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of AMACR mRNA CTD PMID:19162173 NCBI chr 2:60,949,276...60,961,342
Ensembl chr 2:60,949,256...60,961,326 		JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor increases expression ISO Pregnenolone Carbonitrile results in increased expression of AMBP mRNA CTD PMID:28903501 NCBI chr 5:78,975,690...78,986,021
Ensembl chr 5:78,975,678...78,985,990 		JBrowse link
G Amn1 antagonist of mitotic exit network 1 homolog increases expression ISO Pregnenolone Carbonitrile results in increased expression of AMN1 mRNA CTD PMID:28903501 NCBI chr 4:183,670,589...183,697,531
Ensembl chr 4:183,670,596...183,697,531 		JBrowse link
G Amph amphiphysin increases expression EXP Pregnenolone Carbonitrile results in increased expression of AMPH mRNA CTD PMID:19162173 NCBI chr17:48,304,324...48,562,838
Ensembl chr17:48,304,322...48,562,905 		JBrowse link
G Amt aminomethyltransferase decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of AMT mRNA CTD PMID:28903501 NCBI chr 8:117,068,388...117,078,633
Ensembl chr 8:117,068,582...117,077,913 		JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ANGPTL4 mRNA CTD PMID:28903501 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079 		JBrowse link
G Ankib1 ankyrin repeat and IBR domain containing 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ANKIB1 mRNA CTD PMID:28903501 NCBI chr 4:27,473,477...27,597,206
Ensembl chr 4:27,473,477...27,597,206 		JBrowse link
G Ankle1 ankyrin repeat and LEM domain containing 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ANKLE1 mRNA CTD PMID:22698814 NCBI chr16:19,799,943...19,826,057
Ensembl chr16:19,800,463...19,803,796 		JBrowse link
G Ankrd24 ankyrin repeat domain 24 increases expression EXP Pregnenolone Carbonitrile results in increased expression of ANKRD24 mRNA CTD PMID:19162173 NCBI chr 7:10,917,359...10,937,522
Ensembl chr 7:10,917,367...10,936,415 		JBrowse link
G Anks4b ankyrin repeat and sterile alpha motif domain containing 4B decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ANKS4B mRNA CTD PMID:28903501 NCBI chr 1:189,940,305...189,942,113
Ensembl chr 1:189,940,291...189,942,112 		JBrowse link
G Anpep alanyl aminopeptidase, membrane decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ANPEP mRNA CTD PMID:19162173 NCBI chr 1:141,561,364...141,604,249
Ensembl chr 1:141,561,334...141,604,273 		JBrowse link
G Anxa2 annexin A2 multiple interactions ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of ANXA2 mRNA] CTD PMID:20359477 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594 		JBrowse link
G Anxa3 annexin A3 decreases expression
multiple interactions		 EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of ANXA3 mRNA
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of ANXA3 mRNA]		 CTD PMID:19162173, PMID:20359477 NCBI chr14:14,371,921...14,426,503
Ensembl chr14:14,364,008...14,426,437 		JBrowse link
G Anxa4 annexin A4 multiple interactions ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of ANXA4 mRNA] CTD PMID:20359477 NCBI chr 4:118,538,775...118,595,591
Ensembl chr 4:118,538,777...118,595,580 		JBrowse link
G Anxa5 annexin A5 multiple interactions ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of ANXA5 mRNA] CTD PMID:20359477 NCBI chr 2:123,162,477...123,194,730
Ensembl chr 2:123,162,461...123,193,130 		JBrowse link
G Ap3m1 adaptor related protein complex 3 subunit mu 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of AP3M1 mRNA CTD PMID:19162173 NCBI chr15:3,435,998...3,454,281
Ensembl chr15:3,436,361...3,454,279 		JBrowse link
G Apba3 amyloid beta precursor protein binding family A member 3 increases expression EXP Pregnenolone Carbonitrile results in increased expression of APBA3 mRNA CTD PMID:19162173 NCBI chr 7:11,314,468...11,319,540
Ensembl chr 7:11,314,424...11,319,516 		JBrowse link
G Apbb3 amyloid beta precursor protein binding family B member 3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of APBB3 mRNA CTD PMID:28903501 NCBI chr18:29,497,865...29,504,995
Ensembl chr18:29,497,863...29,504,995 		JBrowse link
G Apcs amyloid P component, serum increases expression ISO Pregnenolone Carbonitrile results in increased expression of APCS mRNA CTD PMID:28903501 NCBI chr13:91,426,621...91,427,417
Ensembl chr13:91,426,479...91,427,575 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 decreases expression
increases expression		 EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of APEX1 mRNA
Pregnenolone Carbonitrile results in increased expression of APEX1 mRNA		 CTD PMID:19162173, PMID:28903501 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082 		JBrowse link
G Aplp2 amyloid beta precursor like protein 2 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of APLP2 mRNA CTD PMID:19162173 NCBI chr 8:32,298,526...32,328,821
Ensembl chr 8:32,298,532...32,328,839 		JBrowse link
G Apoa1 apolipoprotein A1 increases expression EXP
ISO		 Pregnenolone Carbonitrile results in increased expression of APOA1 mRNA CTD PMID:19162173, PMID:28903501 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875 		JBrowse link
G Apobec1 apolipoprotein B mRNA editing enzyme catalytic subunit 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of APOBEC1 mRNA CTD PMID:19162173 NCBI chr 4:155,386,367...155,414,034
Ensembl chr 4:155,386,711...155,401,480 		JBrowse link
G Apoc3 apolipoprotein C3 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of APOC3 mRNA CTD PMID:19162173 NCBI chr 8:50,529,318...50,531,498
Ensembl chr 8:50,529,318...50,531,498 		JBrowse link
G Apoc4 apolipoprotein C4 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of APOC4 mRNA CTD PMID:19162173 NCBI chr 1:80,595,339...80,599,525
Ensembl chr 1:80,595,326...80,599,572 		JBrowse link
G Apol3 apolipoprotein L, 3 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of APOL9B mRNA CTD PMID:28903501 NCBI chr 7:118,685,022...118,694,016
Ensembl chr 7:118,685,022...118,694,015 		JBrowse link
G Apol9a apolipoprotein L 9a decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of APOL9A mRNA CTD PMID:28903501 NCBI chr 7:118,927,013...118,933,778
Ensembl chr 7:118,927,008...118,933,812 		JBrowse link
G App amyloid beta precursor protein increases expression EXP Pregnenolone Carbonitrile results in increased expression of APP mRNA CTD PMID:19162173 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Aqp4 aquaporin 4 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of AQP4 mRNA CTD PMID:28903501 NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996 		JBrowse link
G Aqp7 aquaporin 7 increases expression EXP Pregnenolone Carbonitrile results in increased expression of AQP7 mRNA CTD PMID:19162173 NCBI chr 5:57,358,297...57,372,332
Ensembl chr 5:57,358,327...57,372,239 		JBrowse link
G Aqp8 aquaporin 8 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of AQP8 mRNA CTD PMID:28903501 NCBI chr 1:193,424,818...193,430,665
Ensembl chr 1:193,424,812...193,430,676 		JBrowse link
G Aqp9 aquaporin 9 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of AQP9 mRNA CTD PMID:19162173 NCBI chr 8:77,559,621...77,599,781
Ensembl chr 8:77,559,624...77,599,781 		JBrowse link
G Ar androgen receptor increases expression EXP Pregnenolone Carbonitrile results in increased expression of AR mRNA CTD PMID:19162173 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Arhgap29 Rho GTPase activating protein 29 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ARHGAP29 mRNA CTD PMID:28903501 NCBI chr 2:225,552,075...225,613,349
Ensembl chr 2:225,552,148...225,613,359 		JBrowse link
G Arhgef16 Rho guanine nucleotide exchange factor 16 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ARHGEF16 mRNA CTD PMID:28903501 NCBI chr 5:171,626,450...171,649,124
Ensembl chr 5:171,624,796...171,648,563 		JBrowse link
G Arhgef19 Rho guanine nucleotide exchange factor 19 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ARHGEF19 mRNA CTD PMID:28903501 NCBI chr 5:159,754,954...159,773,699
Ensembl chr 5:159,755,535...159,773,699 		JBrowse link
G Arhgef26 Rho guanine nucleotide exchange factor 26 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ARHGEF26 mRNA CTD PMID:28903501 NCBI chr 2:27,107,263...27,236,336
Ensembl chr 2:27,107,318...27,236,672 		JBrowse link
G Arhgef3 Rho guanine nucleotide exchange factor 3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ARHGEF3 mRNA CTD PMID:28903501 NCBI chr16:2,743,714...3,026,768
Ensembl chr16:2,743,823...3,026,760 		JBrowse link
G Arid5a AT-rich interaction domain 5A increases expression ISO Pregnenolone Carbonitrile results in increased expression of ARID5A mRNA CTD PMID:28903501 NCBI chr 9:42,871,907...42,886,725
Ensembl chr 9:42,871,950...42,884,855 		JBrowse link
G Arl4a ADP-ribosylation factor like GTPase 4A increases expression ISO Pregnenolone Carbonitrile results in increased expression of ARL4A mRNA CTD PMID:28903501 NCBI chr 6:59,945,926...59,950,586
Ensembl chr 6:59,948,577...59,950,586 		JBrowse link
G Arl5a ADP-ribosylation factor like GTPase 5A increases expression EXP Pregnenolone Carbonitrile results in increased expression of ARL5A mRNA CTD PMID:19162173 NCBI chr 3:37,922,544...37,947,434
Ensembl chr 3:37,924,793...37,947,283 		JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ARNTL mRNA CTD PMID:27413110 NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465 		JBrowse link
G Arrb1 arrestin, beta 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ARRB1 mRNA CTD PMID:28903501 NCBI chr 1:164,502,099...164,573,947
Ensembl chr 1:164,502,389...164,593,139 		JBrowse link
G Arrdc3 arrestin domain containing 3 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ARRDC3 mRNA CTD PMID:28903501 NCBI chr 2:8,732,907...8,745,445
Ensembl chr 2:8,732,932...8,743,069 		JBrowse link
G Arsa arylsulfatase A decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ARSA mRNA CTD PMID:28903501 NCBI chr 7:130,446,644...130,452,632
Ensembl chr 7:130,446,668...130,451,283 		JBrowse link
G Asb13 ankyrin repeat and SOCS box-containing 13 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ASB13 mRNA CTD PMID:28903501 NCBI chr17:70,215,401...70,234,103
Ensembl chr17:70,215,401...70,234,103 		JBrowse link
G Asf1b anti-silencing function 1B histone chaperone increases expression ISO Pregnenolone Carbonitrile results in increased expression of ASF1B mRNA CTD PMID:22698814 NCBI chr19:25,077,918...25,092,491
Ensembl chr19:25,077,918...25,092,491 		JBrowse link
G Asl argininosuccinate lyase increases expression ISO Pregnenolone Carbonitrile results in increased expression of ASL mRNA CTD PMID:28903501 NCBI chr12:30,160,922...30,178,348
Ensembl chr12:30,165,694...30,178,341 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Pregnenolone Carbonitrile results in increased expression of ASNS mRNA CTD PMID:27413110 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163 		JBrowse link
G Asprv1 aspartic peptidase, retroviral-like 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ASPRV1 mRNA CTD PMID:22698814 NCBI chr 4:118,431,755...118,433,286
Ensembl chr 4:118,431,755...118,432,775 		JBrowse link
G Ass1 argininosuccinate synthase 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ASS1 mRNA CTD PMID:19162173 NCBI chr 3:10,327,411...10,375,847
Ensembl chr 3:10,327,414...10,375,826 		JBrowse link
G Atad1 ATPase family, AAA domain containing 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ATAD1 mRNA CTD PMID:28903501 NCBI chr 1:251,234,702...251,386,996
Ensembl chr 1:251,235,508...251,387,002 		JBrowse link
G Atad3a ATPase family, AAA domain containing 3A increases expression ISO Pregnenolone Carbonitrile results in increased expression of ATAD3A mRNA CTD PMID:28903501 NCBI chr 5:173,189,590...173,209,809
Ensembl chr 5:173,189,592...173,209,768 		JBrowse link
G Atat1 alpha tubulin acetyltransferase 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ATAT1 mRNA CTD PMID:28903501 NCBI chr20:3,351,269...3,364,565
Ensembl chr20:3,351,303...3,364,565 		JBrowse link
G Atf3 activating transcription factor 3 multiple interactions
decreases expression		 ISO NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in decreased expression of ATF3 mRNA] CTD PMID:22698814 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632 		JBrowse link
G Atg14 autophagy related 14 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ATG14 mRNA CTD PMID:28903501 NCBI chr15:24,343,418...24,374,776
Ensembl chr15:24,343,314...24,374,753 		JBrowse link
G Atl2 atlastin GTPase 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ATL2 mRNA CTD PMID:28903501 NCBI chr 6:2,568,975...2,610,432
Ensembl chr 6:2,568,990...2,610,437 		JBrowse link
G Atp10d ATPase phospholipid transporting 10D (putative) increases expression ISO Pregnenolone Carbonitrile results in increased expression of ATP10D mRNA CTD PMID:28903501 NCBI chr14:38,475,956...38,575,937
Ensembl chr14:38,477,330...38,575,785 		JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ATP1B1 mRNA CTD PMID:19162173 NCBI chr13:82,737,161...82,757,681
Ensembl chr13:82,737,159...82,758,004 		JBrowse link
G Atp4a ATPase H+/K+ transporting subunit alpha increases expression ISO Pregnenolone Carbonitrile results in increased expression of ATP4A mRNA CTD PMID:22698814 NCBI chr 1:89,162,700...89,175,504
Ensembl chr 1:89,162,639...89,175,811 		JBrowse link
G Atp5if1 ATP synthase inhibitory factor subunit 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of ATPIF1 mRNA CTD PMID:19162173 NCBI chr 5:150,719,570...150,723,287
Ensembl chr 5:150,719,569...150,723,321 		JBrowse link
G Atp5me ATP synthase membrane subunit e increases expression ISO Pregnenolone Carbonitrile results in increased expression of ATP5K mRNA CTD PMID:28903501 NCBI chr14:2,325,308...2,326,436
Ensembl chr14:2,325,308...2,326,436 		JBrowse link
G Atp6v0a4 ATPase H+ transporting V0 subunit a4 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ATP6V0A4 mRNA CTD PMID:28903501 NCBI chr 4:65,736,585...65,821,916
Ensembl chr 4:65,736,585...65,818,521 		JBrowse link
G Atp6v1d ATPase H+ transporting V1 subunit D increases expression EXP Pregnenolone Carbonitrile results in increased expression of ATP6V1D mRNA CTD PMID:19162173 NCBI chr 6:102,032,271...102,047,754
Ensembl chr 6:102,032,276...102,047,758 		JBrowse link
G Atrn attractin decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ATRN mRNA CTD PMID:19162173 NCBI chr 3:123,434,409...123,567,922
Ensembl chr 3:123,434,409...123,567,918 		JBrowse link
G Atxn7l1 ataxin 7-like 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ATXN7L1 mRNA CTD PMID:28903501 NCBI chr 6:52,459,930...52,680,552
Ensembl chr 6:52,459,946...52,675,574 		JBrowse link
G Avpr1a arginine vasopressin receptor 1A decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of AVPR1A mRNA CTD PMID:19162173 NCBI chr 7:67,341,366...67,345,290
Ensembl chr 7:67,341,080...67,345,308 		JBrowse link
G B3galt1 Beta-1,3-galactosyltransferase 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of B3GALT1 mRNA CTD PMID:28903501 NCBI chr 3:53,699,409...54,269,612
Ensembl chr 3:54,253,949...54,267,292 		JBrowse link
G B3gntl1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of B3GNTL1 mRNA CTD PMID:19162173 NCBI chr10:110,799,409...110,863,075
Ensembl chr10:110,800,864...110,863,021 		JBrowse link
G B4galt1 beta-1,4-galactosyltransferase 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of B4GALT1 mRNA CTD PMID:28903501 NCBI chr 5:57,121,768...57,168,610
Ensembl chr 5:57,121,769...57,168,610 		JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase increases expression ISO Pregnenolone Carbonitrile results in increased expression of BAAT mRNA CTD PMID:27413110 NCBI chr 5:64,768,397...64,777,368
Ensembl chr 5:64,768,401...64,777,368 		JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of BAD mRNA CTD PMID:19162173 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453 		JBrowse link
G Baiap2 BAR/IMD domain containing adaptor protein 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of BAIAP2 mRNA CTD PMID:28903501 NCBI chr10:109,107,326...109,187,458
Ensembl chr10:109,107,389...109,187,115 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of BAK1 protein CTD PMID:19433268 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of BAX protein CTD PMID:19433268 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcat2 branched chain amino acid transaminase 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of BCAT2 mRNA CTD PMID:28903501 NCBI chr 1:101,553,900...101,572,103
Ensembl chr 1:101,554,642...101,572,080 		JBrowse link
G Bche butyrylcholinesterase decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of BCHE mRNA CTD PMID:28903501 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Pregnenolone Carbonitrile results in increased expression of BCL2 mRNA CTD PMID:19162173 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of BCL2A1B mRNA CTD PMID:22698814 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression		 ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of BCL2L1 mRNA]
Pregnenolone Carbonitrile results in increased expression of BCL2L1 mRNA		 CTD PMID:19433268, PMID:28903501 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Bco2 beta-carotene oxygenase 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of BCO2 mRNA CTD PMID:28903501 NCBI chr 8:54,965,577...54,990,604
Ensembl chr 8:54,965,583...54,998,864 		JBrowse link
G Bcor BCL6 co-repressor increases expression ISO Pregnenolone Carbonitrile results in increased expression of BCOR mRNA CTD PMID:28903501 NCBI chr  X:11,570,155...11,692,022
Ensembl chr  X:11,648,989...11,691,099 		JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of BDH1 mRNA CTD PMID:28903501 NCBI chr11:72,577,547...72,619,435
Ensembl chr11:72,578,533...72,614,176 		JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase increases expression ISO Pregnenolone Carbonitrile results in increased expression of BHMT mRNA CTD PMID:28903501 NCBI chr 2:23,236,573...23,256,158
Ensembl chr 2:23,236,575...23,256,158 		JBrowse link
G Bin1 bridging integrator 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of BIN1 mRNA CTD PMID:19162173 NCBI chr18:25,163,575...25,222,139
Ensembl chr18:25,163,561...25,222,135 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression ISO Pregnenolone Carbonitrile results in increased expression of BIRC5 mRNA CTD PMID:22698814, PMID:28903501 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413 		JBrowse link
G Bivm basic, immunoglobulin-like variable motif containing decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of BIVM mRNA CTD PMID:28903501 NCBI chr 9:50,884,888...50,921,133
Ensembl chr 9:50,892,605...50,919,791 		JBrowse link
G Bmper BMP-binding endothelial regulator increases expression ISO Pregnenolone Carbonitrile results in increased expression of BMPER mRNA CTD PMID:28903501 NCBI chr 8:24,369,916...24,615,484
Ensembl chr 8:24,369,916...24,615,479 		JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of BNIP3 mRNA CTD PMID:28903501 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282 		JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression EXP Pregnenolone Carbonitrile results in increased expression of BNIP3L mRNA CTD PMID:19162173 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029 		JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions ISO [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of BRCA1 mRNA CTD PMID:23626729 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681 		JBrowse link
G Brca2 BRCA2, DNA repair associated multiple interactions ISO [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of BRCA2 mRNA CTD PMID:23626729 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748 		JBrowse link
G Brcc3 BRCA1/BRCA2-containing complex, subunit 3 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of BRCC3 mRNA CTD PMID:19162173 NCBI chr 9:9,863,380...9,865,920
Ensembl chr 9:9,863,404...9,865,920 		JBrowse link
G Brix1 biogenesis of ribosomes BRX1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of BRIX1 mRNA CTD PMID:28903501 NCBI chr 2:60,450,547...60,461,425
Ensembl chr 2:60,450,374...60,461,458 		JBrowse link
G Btf3 basic transcription factor 3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of BTF3 mRNA CTD PMID:28903501 NCBI chr 2:28,417,316...28,424,436
Ensembl chr 2:28,417,579...28,423,762 		JBrowse link
G C1qb complement C1q B chain decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of C1QB mRNA CTD PMID:19162173 NCBI chr 5:155,246,444...155,251,995
Ensembl chr 5:155,246,447...155,252,003 		JBrowse link
G C1r complement C1r decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of C1R mRNA CTD PMID:19162173 NCBI chr 4:157,126,060...157,136,825
Ensembl chr 4:157,125,998...157,136,829 		JBrowse link
G C3 complement C3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of C3 mRNA CTD PMID:28903501 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167 		JBrowse link
G C4a complement C4A increases expression ISO Pregnenolone Carbonitrile results in increased expression of C4A mRNA CTD PMID:28903501 NCBI chr20:2,651,599...2,678,183
Ensembl chr20:2,651,599...2,678,141 		JBrowse link
G Ca14 carbonic anhydrase 14 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CAR14 mRNA CTD PMID:28903501 NCBI chr 2:198,010,142...198,017,635
Ensembl chr 2:198,010,349...198,016,898 		JBrowse link
G Ca3 carbonic anhydrase 3 decreases expression EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of CAR3 mRNA CTD PMID:19162173, PMID:28903501 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410 		JBrowse link
G Ca9 carbonic anhydrase 9 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CAR9 mRNA CTD PMID:22698814 NCBI chr 5:59,008,277...59,015,535
Ensembl chr 5:59,008,933...59,015,528 		JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D increases expression ISO Pregnenolone Carbonitrile results in increased expression of CACNA1D mRNA CTD PMID:22698814 NCBI chr16:6,110,294...6,405,022
Ensembl chr16:6,112,150...6,405,117 		JBrowse link
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CACNB4 mRNA CTD PMID:28903501 NCBI chr 3:37,950,846...38,211,478
Ensembl chr 3:37,955,069...38,090,526 		JBrowse link
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CAMK2N1 mRNA CTD PMID:19162173 NCBI chr 5:156,876,706...156,878,486
Ensembl chr 5:156,876,706...156,878,486 		JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CAMKK2 mRNA CTD PMID:19162173 NCBI chr12:39,253,409...39,302,601
Ensembl chr12:39,253,409...39,302,601 		JBrowse link
G Camsap2 calmodulin regulated spectrin-associated protein family, member 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CAMSAP2 mRNA CTD PMID:22698814 NCBI chr13:53,145,712...53,225,349
Ensembl chr13:53,145,712...53,225,349 		JBrowse link
G Casp1 caspase 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CASP1 mRNA CTD PMID:19162173 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions		 EXP
ISO		 Pregnenolone Carbonitrile results in increased expression of CASP3 mRNA
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased cleavage of CASP3 protein]		 CTD PMID:19162173, PMID:19433268 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp6 caspase 6 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CASP6 mRNA CTD PMID:19162173 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967 		JBrowse link
G Cavin3 caveolae associated protein 3 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CAVIN3 mRNA CTD PMID:19162173 NCBI chr 1:170,317,099...170,318,688
Ensembl chr 1:170,317,113...170,318,935 		JBrowse link
G Cbx2 chromobox 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CBX2 mRNA CTD PMID:28903501 NCBI chr10:108,132,105...108,140,935
Ensembl chr10:108,132,105...108,140,935 		JBrowse link
G Cbx4 chromobox 4 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CBX4 mRNA CTD PMID:28903501 NCBI chr10:108,190,947...108,196,455
Ensembl chr10:108,190,995...108,196,217 		JBrowse link
G Cbx5 chromobox 5 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CBX5 mRNA CTD PMID:19162173 NCBI chr 7:144,819,673...144,865,014
Ensembl chr 7:144,819,420...144,837,583 		JBrowse link
G Cbx8 chromobox 8 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CBX8 mRNA CTD PMID:28903501 NCBI chr10:108,148,073...108,150,511
Ensembl chr10:108,148,073...108,150,511 		JBrowse link
G Cc2d2a coiled-coil and C2 domain containing 2A decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CC2D2A mRNA CTD PMID:28903501 NCBI chr14:71,895,128...71,979,452
Ensembl chr14:71,895,246...71,973,419 		JBrowse link
G Ccdc86 coiled-coil domain containing 86 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CCDC86 mRNA CTD PMID:28903501 NCBI chr 1:226,996,435...227,002,016
Ensembl chr 1:226,996,237...227,002,139 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions		 ISO Pregnenolone Carbonitrile results in decreased expression of CCL2 mRNA
NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in decreased expression of CCL2 mRNA]		 CTD PMID:22698814 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl6 chemokine (C-C motif) ligand 6 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CCL6 mRNA CTD PMID:28903501 NCBI chr10:70,798,118...70,802,750
Ensembl chr10:70,797,124...70,802,782 		JBrowse link
G Ccn1 cellular communication network factor 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CCN1 mRNA CTD PMID:28903501 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312 		JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CCN2 mRNA CTD PMID:28903501 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773 		JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of CCNA2 mRNA; [Phenobarbital co-treated with Pregnenolone Carbonitrile] results in increased expression of CCNA2 mRNA; [pirinixic acid co-treated with Pregnenolone Carbonitrile] results in increased expression of CCNA2 mRNA CTD PMID:23626729 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214 		JBrowse link
G Ccnb1 cyclin B1 increases expression
multiple interactions		 EXP
ISO		 Pregnenolone Carbonitrile results in increased expression of CCNB1 mRNA
[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of CCNB1 mRNA; [pirinixic acid co-treated with Pregnenolone Carbonitrile] results in increased expression of CCNB1 mRNA		 CTD PMID:19162173, PMID:23626729 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221 		JBrowse link
G Ccnb2 cyclin B2 multiple interactions ISO [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of CCNB2 mRNA CTD PMID:23626729 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccnd1 cyclin D1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CCND1 mRNA CTD PMID:19162173 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Ccnf cyclin F decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CCNF mRNA CTD PMID:28903501 NCBI chr10:13,594,687...13,619,935
Ensembl chr10:13,594,687...13,619,935 		JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CCT2 mRNA CTD PMID:28903501 NCBI chr 7:60,106,532...60,122,779
Ensembl chr 7:60,109,974...60,122,805 		JBrowse link
G Cct3 chaperonin containing TCP1 subunit 3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CCT3 mRNA CTD PMID:28903501 NCBI chr 2:187,669,051...187,693,610
Ensembl chr 2:187,668,796...187,693,610 		JBrowse link
G Cd19 CD19 molecule decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CD19 mRNA CTD PMID:28903501 NCBI chr 1:197,815,422...197,822,123
Ensembl chr 1:197,815,413...197,821,936 		JBrowse link
G Cd22 CD22 molecule decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CD22 mRNA CTD PMID:28903501 NCBI chr 1:89,313,475...89,329,902
Ensembl chr 1:89,314,558...89,329,418 		JBrowse link
G Cd36 CD36 molecule decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CD36 mRNA CTD PMID:19162173 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749 		JBrowse link
G Cd74 CD74 molecule decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CD74 mRNA CTD PMID:19162173 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849 		JBrowse link
G Cd81 Cd81 molecule decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CD81 mRNA CTD PMID:19162173 NCBI chr 1:216,237,663...216,253,460
Ensembl chr 1:216,237,697...216,253,311 		JBrowse link
G Cd82 Cd82 molecule increases expression EXP Pregnenolone Carbonitrile results in increased expression of CD82 mRNA CTD PMID:19162173 NCBI chr 3:82,324,344...82,368,846
Ensembl chr 3:82,324,354...82,368,357 		JBrowse link
G Cdc14b cell division cycle 14B decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CDC14B mRNA CTD PMID:28903501 NCBI chr17:1,709,703...1,797,732
Ensembl chr17:1,703,943...1,797,750 		JBrowse link
G Cdc20 cell division cycle 20 increases expression
multiple interactions		 EXP
ISO		 Pregnenolone Carbonitrile results in increased expression of CDC20 mRNA
NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CDC20 mRNA]		 CTD PMID:19162173, PMID:21318169, PMID:22698814 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015 		JBrowse link
G Cdc45 cell division cycle 45 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CDC45 mRNA CTD PMID:22698814 NCBI chr11:86,328,785...86,354,099
Ensembl chr11:86,329,012...86,358,453 		JBrowse link
G Cdca3 cell division cycle associated 3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CDCA3 mRNA CTD PMID:22698814 NCBI chr 4:157,347,876...157,351,889
Ensembl chr 4:157,348,020...157,351,604 		JBrowse link
G Cdca8 cell division cycle associated 8 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CDCA8 mRNA CTD PMID:22698814 NCBI chr 5:142,911,310...142,933,536
Ensembl chr 5:142,911,305...142,933,526 		JBrowse link
G Cdh15 cadherin 15 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CDH15 mRNA CTD PMID:28903501 NCBI chr19:55,669,661...55,689,986
Ensembl chr19:55,669,626...55,689,992 		JBrowse link
G Cdh2 cadherin 2 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CDH2 mRNA CTD PMID:19162173 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684 		JBrowse link
G Cdhr5 cadherin-related family member 5 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CDHR5 mRNA CTD PMID:28903501 NCBI chr 1:214,255,118...214,263,848
Ensembl chr 1:214,255,110...214,263,581 		JBrowse link
G Cdip1 cell death-inducing p53 target 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CDIP1 mRNA CTD PMID:28903501 NCBI chr10:10,966,819...10,989,937
Ensembl chr10:10,967,658...10,989,936 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression
multiple interactions		 ISO Pregnenolone Carbonitrile results in increased expression of CDK1 mRNA
NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CDK1 mRNA]		 CTD PMID:22698814 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549 		JBrowse link
G Cdk18 cyclin-dependent kinase 18 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CDK18 mRNA CTD PMID:28903501 NCBI chr13:48,893,525...48,926,673
Ensembl chr13:48,893,412...48,927,483 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Pregnenolone Carbonitrile results in increased expression of CDKN1A mRNA CTD PMID:28903501 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CDKN3 mRNA CTD PMID:22698814 NCBI chr15:23,553,171...23,564,538
Ensembl chr15:23,553,128...23,564,535 		JBrowse link
G Cdo1 cysteine dioxygenase type 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CDO1 mRNA CTD PMID:19162173 NCBI chr18:40,702,027...40,716,901
Ensembl chr18:40,701,984...40,716,686 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CEBPA mRNA CTD PMID:28903501 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression EXP
ISO		 Pregnenolone Carbonitrile results in increased expression of CEBPB mRNA CTD PMID:19162173, PMID:28903501 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910 		JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression ISO Pregnenolone Carbonitrile results in increased expression of CEBPD mRNA CTD PMID:28903501 NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146 		JBrowse link
G Cebpzos CEBPZ opposite strand increases expression ISO Pregnenolone Carbonitrile results in increased expression of CEBPZOS mRNA CTD PMID:28903501 NCBI chr 6:1,514,191...1,518,858
Ensembl chr 6:1,516,158...1,517,618 		JBrowse link
G Celf1 CUGBP, Elav-like family member 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CELF1 mRNA CTD PMID:19162173 NCBI chr 3:79,768,900...79,844,548
Ensembl chr 3:79,823,945...79,842,082 		JBrowse link
G Cenpe centromere protein E increases expression ISO Pregnenolone Carbonitrile results in increased expression of CENPE mRNA CTD PMID:22698814 NCBI chr 2:240,395,974...240,454,785
Ensembl chr 2:240,396,152...240,454,747 		JBrowse link
G Cenph centromere protein H increases expression ISO Pregnenolone Carbonitrile results in increased expression of CENPH mRNA CTD PMID:22698814 NCBI chr 2:30,766,637...30,780,123
Ensembl chr 2:30,766,590...30,780,121 		JBrowse link
G Cenpp centromere protein P increases expression ISO Pregnenolone Carbonitrile results in increased expression of CENPP mRNA CTD PMID:22698814 NCBI chr17:15,429,526...15,603,197
Ensembl chr17:15,429,708...15,603,199 		JBrowse link
G Ces1d carboxylesterase 1D multiple interactions
increases expression		 ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CES1D mRNA]
Pregnenolone Carbonitrile results in increased expression of CES1D mRNA; Pregnenolone Carbonitrile results in increased expression of CES1D protein		 CTD PMID:20359477, PMID:26179144, PMID:28903501 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821 		JBrowse link
G Ces2c carboxylesterase 2C multiple interactions
increases expression		 ISO NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of CES2C mRNA] CTD PMID:22429928, PMID:26179144 NCBI chr 1:282,640,752...282,648,319
Ensembl chr 1:282,638,017...282,702,424 		JBrowse link
G Ces2h carboxylesterase 2H increases expression EXP Pregnenolone Carbonitrile results in increased expression of CES2 mRNA CTD PMID:19162173 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156 		JBrowse link
G Ces3a carboxylesterase 3a decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CES3B mRNA CTD PMID:28903501 NCBI chr19:37,070,705...37,079,411 JBrowse link
G Cgn cingulin decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CGN mRNA CTD PMID:28903501 NCBI chr 2:195,909,691...195,937,130
Ensembl chr 2:195,909,626...195,935,878 		JBrowse link
G Ch25h cholesterol 25-hydroxylase decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CH25H mRNA CTD PMID:22698814 NCBI chr 1:252,807,062...252,811,409
Ensembl chr 1:252,807,065...252,808,380 		JBrowse link
G Chac2 ChaC glutathione specific gamma-glutamylcyclotransferase 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CHAC2 mRNA CTD PMID:28903501 NCBI chr14:115,383,906...115,391,757
Ensembl chr14:115,383,910...115,391,652 		JBrowse link
G Chaf1a chromatin assembly factor 1 subunit A increases expression
decreases expression		 ISO Pregnenolone Carbonitrile results in increased expression of CHAF1A mRNA
Pregnenolone Carbonitrile results in decreased expression of CHAF1A mRNA		 CTD PMID:22698814, PMID:28903501 NCBI chr 9:11,000,869...11,027,631
Ensembl chr 9:11,001,129...11,027,506 		JBrowse link
G Chchd4 coiled-coil-helix-coiled-coil-helix domain containing 4 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CHCHD4 mRNA CTD PMID:28903501 NCBI chr 4:123,108,924...123,118,186
Ensembl chr 4:123,108,925...123,118,186 		JBrowse link
G Chchd6 coiled-coil-helix-coiled-coil-helix domain containing 6 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CHCHD6 mRNA CTD PMID:19162173 NCBI chr 4:121,340,952...121,565,222
Ensembl chr 4:121,340,952...121,565,212 		JBrowse link
G Chd1l chromodomain helicase DNA binding protein 1-like increases expression ISO Pregnenolone Carbonitrile results in increased expression of CHD1L mRNA CTD PMID:28903501 NCBI chr 2:199,714,044...199,792,270
Ensembl chr 2:199,716,713...199,771,896 		JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of CHEK1 mRNA CTD PMID:23626729 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882 		JBrowse link
G Chka choline kinase alpha decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CHKA mRNA CTD PMID:28903501 NCBI chr 1:219,076,618...219,126,221
Ensembl chr 1:219,077,771...219,126,220 		JBrowse link
G Chordc1 cysteine and histidine rich domain containing 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CHORDC1 mRNA CTD PMID:19162173 NCBI chr 8:17,421,552...17,445,513
Ensembl chr 8:17,421,557...17,446,165 		JBrowse link
G Chpt1 choline phosphotransferase 1 multiple interactions ISO [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of CHPT1 mRNA CTD PMID:20359477 NCBI chr 7:29,019,518...29,070,928
Ensembl chr 7:29,043,916...29,070,928 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CHRM1 mRNA CTD PMID:19162173 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CHRM3 mRNA CTD PMID:19162173 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169 		JBrowse link
G Chst15 carbohydrate sulfotransferase 15 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CHST15 mRNA CTD PMID:28903501 NCBI chr 1:204,243,396...204,328,960
Ensembl chr 1:204,245,645...204,322,544 		JBrowse link
G Chtf18 chromosome transmission fidelity factor 18 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CHTF18 mRNA CTD PMID:22698814 NCBI chr10:15,090,762...15,098,825
Ensembl chr10:15,090,316...15,098,791 		JBrowse link
G Ciao1 cytosolic iron-sulfur assembly component 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CIAO1 mRNA CTD PMID:19162173 NCBI chr 3:119,671,778...119,677,324
Ensembl chr 3:119,671,779...119,678,092 		JBrowse link
G Cidea cell death-inducing DFFA-like effector a increases expression EXP Pregnenolone Carbonitrile results in increased expression of CIDEA mRNA CTD PMID:19162173 NCBI chr18:63,082,861...63,108,450
Ensembl chr18:63,098,144...63,108,051 		JBrowse link
G Ciita class II, major histocompatibility complex, transactivator decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CIITA mRNA CTD PMID:22698814 NCBI chr10:5,212,621...5,260,641
Ensembl chr10:5,213,350...5,260,608 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of CITED2 mRNA CTD PMID:19162173, PMID:28903501 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786 		JBrowse link
G Ckb creatine kinase B decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CKB mRNA CTD PMID:19162173 NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837 		JBrowse link
G Cks1b CDC28 protein kinase regulatory subunit 1B multiple interactions ISO [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of CKS1B mRNA CTD PMID:23626729 NCBI chr 2:188,740,564...188,745,144
Ensembl chr 2:188,740,573...188,745,144 		JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CKS2 mRNA CTD PMID:28903501 NCBI chr17:13,587,664...13,593,423
Ensembl chr17:13,587,665...13,593,423 		JBrowse link
G Cldn14 claudin 14 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CLDN14 mRNA CTD PMID:28903501 NCBI chr11:34,132,581...34,142,813
Ensembl chr11:34,132,581...34,142,753 		JBrowse link
G Cldn3 claudin 3 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CLDN3 mRNA CTD PMID:19162173 NCBI chr12:21,831,341...21,832,813
Ensembl chr12:21,831,342...21,832,813 		JBrowse link
G Clec4d C-type lectin domain family 4, member D decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CLEC4D mRNA CTD PMID:22698814 NCBI chr 4:156,253,084...156,264,766
Ensembl chr 4:156,253,079...156,264,769 		JBrowse link
G Clec9a C-type lectin domain containing 9A increases expression ISO Pregnenolone Carbonitrile results in increased expression of CLEC9A mRNA CTD PMID:28903501 NCBI chr 4:163,173,593...163,189,532
Ensembl chr 4:163,174,487...163,189,530 		JBrowse link
G Clic3 chloride intracellular channel 3 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CLIC3 mRNA CTD PMID:28903501 NCBI chr 3:2,675,732...2,678,248
Ensembl chr 3:2,676,296...2,680,565 		JBrowse link
G Clstn3 calsyntenin 3 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CLSTN3 mRNA CTD PMID:28903501 NCBI chr 4:157,044,736...157,078,013
Ensembl chr 4:157,043,925...157,078,130 		JBrowse link
G Cltb clathrin, light chain B increases expression EXP
ISO		 Pregnenolone Carbonitrile results in increased expression of CLTB mRNA CTD PMID:19162173, PMID:28903501 NCBI chr17:10,537,348...10,554,999
Ensembl chr17:10,537,365...10,554,989 		JBrowse link
G Clu clusterin increases expression ISO Pregnenolone Carbonitrile results in increased expression of CLU mRNA CTD PMID:28903501 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857 		JBrowse link
G Cnrip1 cannabinoid receptor interacting protein 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CNRIP1 mRNA CTD PMID:22698814 NCBI chr14:100,217,547...100,247,235
Ensembl chr14:100,217,289...100,247,235 		JBrowse link
G Cntn5 contactin 5 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CNTN5 mRNA CTD PMID:22698814 NCBI chr 8:7,812,371...9,033,962
Ensembl chr 8:7,814,895...8,524,643 		JBrowse link
G Col15a1 collagen type XV alpha 1 chain decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of COL15A1 mRNA CTD PMID:28903501 NCBI chr 5:62,840,360...62,950,240 JBrowse link
G Colgalt2 collagen beta(1-O)galactosyltransferase 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of COLGALT2 mRNA CTD PMID:22698814, PMID:28903501 NCBI chr13:69,797,558...69,902,916
Ensembl chr13:69,797,880...69,901,170 		JBrowse link
G Comt catechol-O-methyltransferase decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of COMT mRNA CTD PMID:19162173 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622 		JBrowse link
G Coro2a coronin 2A decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CORO2A mRNA CTD PMID:28903501 NCBI chr 5:62,154,526...62,210,797
Ensembl chr 5:62,156,839...62,187,930 		JBrowse link
G Cox5a cytochrome c oxidase subunit 5A decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of COX5A mRNA CTD PMID:19162173 NCBI chr 8:62,298,358...62,309,765
Ensembl chr 8:62,298,358...62,309,765 		JBrowse link
G Cox8a cytochrome c oxidase subunit 8A decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of COX8A mRNA CTD PMID:19162173 NCBI chr 1:222,466,575...222,468,896
Ensembl chr 1:222,466,575...222,468,896 		JBrowse link
G Cpb2 carboxypeptidase B2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CPB2 mRNA CTD PMID:28903501 NCBI chr15:57,290,849...57,339,762
Ensembl chr15:57,290,849...57,339,760 		JBrowse link
G Cpeb2 cytoplasmic polyadenylation element binding protein 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CPEB2 mRNA CTD PMID:22698814 NCBI chr14:72,327,929...72,382,519
Ensembl chr14:72,331,705...72,380,330 		JBrowse link
G Cpne8 copine 8 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CPNE8 mRNA CTD PMID:28903501 NCBI chr 7:131,623,180...131,798,236
Ensembl chr 7:131,623,181...131,798,236 		JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CPS1 mRNA CTD PMID:19162173 NCBI chr 9:74,113,437...74,236,274
Ensembl chr 9:74,124,016...74,236,274 		JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CPT1B mRNA CTD PMID:19162173 NCBI chr 7:130,395,211...130,404,731
Ensembl chr 7:130,395,194...130,405,347 		JBrowse link
G Cpxm2 carboxypeptidase X (M14 family), member 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CPXM2 mRNA CTD PMID:22698814 NCBI chr 1:204,048,785...204,161,090
Ensembl chr 1:204,048,785...204,087,001 		JBrowse link
G Crcp CGRP receptor component increases expression ISO Pregnenolone Carbonitrile results in increased expression of CRCP mRNA CTD PMID:28903501 NCBI chr12:30,125,237...30,160,857
Ensembl chr12:30,125,168...30,180,115 		JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CREG1 mRNA CTD PMID:19162173 NCBI chr13:83,972,186...83,984,675
Ensembl chr13:83,972,212...83,984,675 		JBrowse link
G Crip2 cysteine-rich protein 2 decreases expression
increases expression		 EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of CRIP2 mRNA
Pregnenolone Carbonitrile results in increased expression of CRIP2 mRNA		 CTD PMID:19162173, PMID:28903501 NCBI chr 6:137,953,545...137,958,491
Ensembl chr 6:137,953,545...137,958,490 		JBrowse link
G Crot carnitine O-octanoyltransferase decreases expression
multiple interactions		 EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of CROT mRNA
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CROT mRNA]		 CTD PMID:19162173, PMID:20359477, PMID:28903501 NCBI chr 4:22,079,837...22,116,265
Ensembl chr 4:22,081,604...22,116,265 		JBrowse link
G Crp C-reactive protein increases expression ISO Pregnenolone Carbonitrile results in increased expression of CRP mRNA CTD PMID:28903501 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713 		JBrowse link
G Cryaa crystallin, alpha A increases expression EXP Pregnenolone Carbonitrile results in increased expression of CRYAA mRNA CTD PMID:19162173 NCBI chr20:10,438,444...10,442,189
Ensembl chr20:10,438,444...10,442,187 		JBrowse link
G Crybb1 crystallin, beta B1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CRYBB1 mRNA CTD PMID:22698814 NCBI chr12:50,390,939...50,404,550
Ensembl chr12:50,390,940...50,404,550 		JBrowse link
G Crybb3 crystallin, beta B3 decreases expression
increases expression		 ISO Pregnenolone Carbonitrile results in decreased expression of CRYBB3 mRNA
Pregnenolone Carbonitrile results in increased expression of CRYBB3 mRNA		 CTD PMID:22698814, PMID:28903501 NCBI chr12:49,564,991...49,571,008
Ensembl chr12:49,565,992...49,571,006 		JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta increases expression ISO Pregnenolone Carbonitrile results in increased expression of CSF2RB mRNA; Pregnenolone Carbonitrile results in increased expression of CSF2RB2 mRNA CTD PMID:28903501 NCBI chr 7:119,554,383...119,568,248
Ensembl chr 7:119,554,354...119,568,776 		JBrowse link
G Csrnp1 cysteine and serine rich nuclear protein 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CSRNP1 mRNA CTD PMID:28903501 NCBI chr 8:128,659,883...128,673,339
Ensembl chr 8:128,659,868...128,672,284 		JBrowse link
G Cstb cystatin B decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CSTB mRNA CTD PMID:19162173 NCBI chr20:10,966,357...10,968,399
Ensembl chr20:10,966,331...10,968,432 		JBrowse link
G Cth cystathionine gamma-lyase decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CTH mRNA CTD PMID:19162173 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046 		JBrowse link
G Ctnnd2 catenin delta 2 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CTNND2 mRNA CTD PMID:19162173 NCBI chr 2:83,227,247...84,094,315
Ensembl chr 2:83,393,282...84,094,315 		JBrowse link
G Ctps1 CTP synthase 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CTPS mRNA CTD PMID:28903501 NCBI chr 5:139,475,934...139,505,065
Ensembl chr 5:139,475,934...139,505,065 		JBrowse link
G Ctsd cathepsin D increases expression EXP Pregnenolone Carbonitrile results in increased expression of CTSD mRNA CTD PMID:19162173 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451 		JBrowse link
G Ctsl cathepsin L decreases expression
increases expression		 EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of CTSL mRNA
Pregnenolone Carbonitrile results in increased expression of CTSL mRNA		 CTD PMID:19162173, PMID:28903501 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279 		JBrowse link
G Ctss cathepsin S decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CTSS mRNA CTD PMID:19162173 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458 		JBrowse link
G Cuta cutA divalent cation tolerance homolog decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CUTA mRNA CTD PMID:19162173 NCBI chr20:5,532,024...5,533,640
Ensembl chr20:5,532,024...5,533,620 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CXCL1 mRNA CTD PMID:27413110, PMID:28903501 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595 		JBrowse link
G Cyb561 cytochrome b-561 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CYB561 mRNA CTD PMID:28903501 NCBI chr10:94,136,993...94,147,567
Ensembl chr10:94,136,993...94,147,621 		JBrowse link
G Cyb5a cytochrome b5 type A affects expression
increases expression		 EXP
ISO		 Pregnenolone Carbonitrile affects the expression of CYB5A mRNA
Pregnenolone Carbonitrile results in increased expression of CYB5A mRNA		 CTD PMID:19162173, PMID:28903501 NCBI chr18:81,694,818...81,726,821
Ensembl chr18:81,694,808...81,726,821 		JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CYB5R3 mRNA CTD PMID:19162173 NCBI chr 7:124,024,003...124,041,564
Ensembl chr 7:124,023,995...124,041,594 		JBrowse link
G Cyc1 cytochrome c-1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CYC1 mRNA CTD PMID:19162173 NCBI chr 7:117,409,576...117,411,953
Ensembl chr 7:117,409,576...117,411,953 		JBrowse link
G Cycs cytochrome c, somatic decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CYCS mRNA CTD PMID:19162173 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CYP17A1 mRNA CTD PMID:19162173 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression
multiple interactions
increases expression		 EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of CYP1A1 mRNA
Pregnenolone Carbonitrile inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Pregnenolone Carbonitrile inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]
Pregnenolone Carbonitrile results in increased expression of CYP1A1 mRNA		 CTD PMID:19118567, PMID:19162173, PMID:28428138 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression
multiple interactions
increases expression		 EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of CYP1A2 mRNA
NR1I2 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in decreased expression of CYP1A2 mRNA]
Pregnenolone Carbonitrile inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A2 mRNA]
Pregnenolone Carbonitrile results in increased expression of CYP1A2 mRNA		 CTD PMID:15596064, PMID:19162173, PMID:27413110, PMID:28428138, PMID:29548889, PMID:31388680 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO Pregnenolone Carbonitrile inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1B1 mRNA] CTD PMID:28428138 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CYP21A1 mRNA CTD PMID:28903501 NCBI chr20:4,486,213...4,489,358
Ensembl chr20:4,486,219...4,489,550 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CYP24A1 mRNA CTD PMID:15630458 NCBI chr 3:168,097,484...168,111,920
Ensembl chr 3:168,097,485...168,111,920 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CYP26A1 mRNA CTD PMID:28903501 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CYP27A1 mRNA CTD PMID:28903501 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169 		JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CYP2A1 mRNA CTD PMID:15596064 NCBI chr 1:83,711,223...83,725,222
Ensembl chr 1:83,653,234...83,766,484 		JBrowse link
G Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CYP2A2 mRNA CTD PMID:19162173 NCBI chr 1:83,744,229...83,766,490
Ensembl chr 1:83,653,234...83,766,484 		JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CYP2A5 mRNA CTD PMID:27413110 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
affects expression
increases expression		 ISO
EXP		 [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP2B10 mRNA; [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP2B10 mRNA; [Phenobarbital co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP2B10 mRNA; [Pregnenolone Carbonitrile co-treated with Lithocholic Acid] results in increased expression of CYP2B10 mRNA; [Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to CYP2B10 gene]] which results in increased expression of CYP2B10 mRNA; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of CYP2B10 mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP2B10 mRNA]; NR1I3 protein promotes the reaction [[Pregnenolone Carbonitrile co-treated with Lithocholic Acid] results in increased expression of CYP2B10 mRNA]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to CYP2B10 gene]
Pregnenolone Carbonitrile affects the expression of CYP2B10 mRNA
Pregnenolone Carbonitrile results in increased expression of CYP2B1 mRNA
NR1I2 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of CYP2B1 mRNA]
Pregnenolone Carbonitrile results in increased expression of CYP2B10 mRNA; Pregnenolone Carbonitrile results in increased expression of CYP2B10 protein		 CTD PMID:15986414, PMID:17627975, PMID:18488193, PMID:19433268, PMID:20359477, PMID:20693526, PMID:22496397, PMID:22698814, PMID:23626729, PMID:25949234, PMID:27413110, PMID:28903501, PMID:29222744, PMID:29548889, PMID:31388680 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783 		JBrowse link
G Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CYP2B15 mRNA CTD PMID:19162173, PMID:19850644 NCBI chr 1:251,325,923...251,338,404
Ensembl chr 1:251,325,923...251,338,358 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression
multiple interactions		 EXP
ISO		 Pregnenolone Carbonitrile results in increased expression of CYP2B2 mRNA
NR1I2 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of CYP2B2 mRNA]
Pregnenolone Carbonitrile results in increased expression of CYP2B13 mRNA		 CTD PMID:15596064, PMID:19162173, PMID:19850644, PMID:27413110, PMID:29548889 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases expression
increases expression		 EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of CYP2B3 mRNA
Pregnenolone Carbonitrile results in decreased expression of CYP2B9 mRNA
Pregnenolone Carbonitrile results in increased expression of CYP2B3 mRNA		 CTD PMID:15596064, PMID:19162173, PMID:27413110, PMID:28903501 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CYP2C mRNA CTD PMID:19162173 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434 		JBrowse link
G Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CYP2C22 mRNA CTD PMID:19162173 NCBI chr 1:259,257,658...259,297,270
Ensembl chr 1:259,257,657...259,287,684 		JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 multiple interactions
increases expression		 ISO NR1I2 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of CYP2C55 mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP2C55 mRNA] CTD PMID:20371638, PMID:22698814, PMID:27413110, PMID:28903501 NCBI chr 1:258,074,797...258,139,176
Ensembl chr 1:258,074,860...258,139,176 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CYP2C38 mRNA CTD PMID:28903501 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases expression ISO Pregnenolone Carbonitrile results in increased expression of CYP2C29 mRNA CTD PMID:28903501 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CYP2D3 mRNA CTD PMID:19162173 NCBI chr 7:123,634,400...123,638,757
Ensembl chr 7:123,625,590...123,638,765 		JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 decreases expression
increases expression		 EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of CYP2F4 mRNA
Pregnenolone Carbonitrile results in decreased expression of CYP2F2 mRNA
Pregnenolone Carbonitrile results in increased expression of CYP2F1 mRNA		 CTD PMID:15596064, PMID:19162173, PMID:27413110 NCBI chr 1:83,933,974...83,947,804
Ensembl chr 1:83,933,942...83,947,821 		JBrowse link
G Cyp2j3 cytochrome P450, family 2, subfamily j, polypeptide 3 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CYP2J3 mRNA CTD PMID:19162173 NCBI chr 5:115,196,982...115,222,084 JBrowse link
G Cyp2u1 cytochrome P450, family 2, subfamily u, polypeptide 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CYP2U1 mRNA CTD PMID:28903501 NCBI chr 2:236,414,131...236,431,650
Ensembl chr 2:236,414,135...236,431,683 		JBrowse link
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CYP3A18 mRNA CTD PMID:15596064, PMID:19162173, PMID:19850644 NCBI chr12:10,636,294...10,684,273
Ensembl chr12:10,636,275...10,684,278 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression
increases activity		 EXP [NR1I2 protein co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP3A4 mRNA; allyl isothiocyanate inhibits the reaction [[NR1I2 protein co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP3A4 mRNA]; Pregnenolone Carbonitrile results in increased expression of and results in increased activity of CYP3A2 protein
Pregnenolone Carbonitrile results in increased expression of CYP3A2 mRNA; Pregnenolone Carbonitrile results in increased expression of CYP3A2 protein
Pregnenolone Carbonitrile results in increased activity of CYP3A2 protein		 CTD PMID:12458634, PMID:15588932, PMID:15946133, PMID:16673044, PMID:19162173, PMID:19850644, PMID:25069801, PMID:29366910 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions
increases activity
increases expression		 EXP [Dietary Fats co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP3A23-3A1 protein; Clofibrate promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A23-3A1 protein]; diphenyleneiodonium inhibits the reaction [Pregnenolone Carbonitrile results in increased activity of CYP3A23-3A1 protein]; NR1I2 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A23-3A1 mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A23-3A1 mRNA]; perfluorodecanoic acid inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A23-3A1 protein]; Pregnenolone Carbonitrile promotes the reaction [[NR1I2 protein co-treated with RXRA protein] binds to CYP3A23-3A1 promoter]
Pregnenolone Carbonitrile results in increased expression of CYP3A23-3A1 mRNA; Pregnenolone Carbonitrile results in increased expression of CYP3A23-3A1 protein		 CTD PMID:9817075, PMID:10772642, PMID:11752103, PMID:12370413, PMID:12869653, PMID:14613717, PMID:15596064, PMID:15826607, PMID:16125621, PMID:16673044, PMID:19118567, PMID:19162173, PMID:19562681, PMID:19850644, PMID:20888898, PMID:21742782, PMID:22037397, PMID:26616219, PMID:26880746, PMID:29548889 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression EXP
ISO		 Pregnenolone Carbonitrile results in increased expression of CYP3A9 mRNA
Pregnenolone Carbonitrile results in increased expression of CYP3A13 mRNA		 CTD PMID:15596064, PMID:19162173, PMID:19562681, PMID:19850644, PMID:20888898, PMID:28903501 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399 		JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 decreases expression EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of CYP4A1 mRNA
Pregnenolone Carbonitrile results in decreased expression of CYP4A12B mRNA		 CTD PMID:19162173, PMID:28903501, PMID:29548889 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154 		JBrowse link
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CYP4A2 mRNA CTD PMID:19162173 NCBI chr 5:134,196,910...134,207,888
Ensembl chr 5:134,196,912...134,207,863 		JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CYP4A3 mRNA CTD PMID:19162173 NCBI chr 5:134,468,666...134,484,851
Ensembl chr 5:134,469,270...134,484,839 		JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CYP4B1 mRNA CTD PMID:15596064 NCBI chr 5:134,508,728...134,526,103
Ensembl chr 5:134,508,730...134,526,089 		JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 decreases expression
multiple interactions		 ISO Pregnenolone Carbonitrile results in decreased expression of CYP4F14 mRNA
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CYP4F14 mRNA]		 CTD PMID:20359477, PMID:28903501 NCBI chr 7:15,179,472...15,191,113
Ensembl chr 7:15,179,467...15,190,796 		JBrowse link
G Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CYP4F4 mRNA CTD PMID:15596064 NCBI chr 7:14,891,062...14,907,250
Ensembl chr 7:14,891,001...14,907,305 		JBrowse link
G Cyp4f5 cytochrome P450, family 4, subfamily f, polypeptide 5 increases expression EXP Pregnenolone Carbonitrile results in increased expression of CYP4F5 mRNA CTD PMID:19162173 NCBI chr 7:14,559,806...14,574,345
Ensembl chr 7:14,529,482...14,574,361 		JBrowse link
G Cyp4v3 cytochrome P450, family 4, subfamily v, polypeptide 3 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of CYP4V3 mRNA CTD PMID:28903501 NCBI chr16:50,111,803...50,136,741
Ensembl chr16:50,111,306...50,136,727 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression
multiple interactions		 EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of CYP7A1 mRNA
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA]		 CTD PMID:15629111, PMID:19162173, PMID:20359477, PMID:22982774, PMID:27413110, PMID:28903501 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of CYP7B1 mRNA CTD PMID:19162173 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA] CTD PMID:20359477 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388 		JBrowse link
G Daam1 dishevelled associated activator of morphogenesis 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DAAM1 mRNA CTD PMID:28903501 NCBI chr 6:94,606,675...94,739,026
Ensembl chr 6:94,636,222...94,739,026 		JBrowse link
G Dact2 dishevelled-binding antagonist of beta-catenin 2 increases expression EXP Pregnenolone Carbonitrile results in increased expression of DACT2 mRNA CTD PMID:19162173 NCBI chr 1:56,159,435...56,169,443
Ensembl chr 1:56,159,426...56,168,351 		JBrowse link
G Dancr differentiation antagonizing non-protein coding RNA increases expression ISO Pregnenolone Carbonitrile results in increased expression of DANCR mRNA CTD PMID:28903501 NCBI chr14:36,664,036...36,665,016 JBrowse link
G Dapk3 death-associated protein kinase 3 increases expression EXP Pregnenolone Carbonitrile results in increased expression of DAPK3 mRNA CTD PMID:19162173 NCBI chr 7:11,392,436...11,400,855
Ensembl chr 7:11,392,437...11,400,805 		JBrowse link
G Dbndd1 dysbindin domain containing 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of DBNDD1 mRNA CTD PMID:22698814 NCBI chr19:56,302,704...56,311,991
Ensembl chr19:56,302,705...56,311,991 		JBrowse link
G Dbp D-box binding PAR bZIP transcription factor decreases expression
increases expression		 EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of DBP mRNA
Pregnenolone Carbonitrile results in increased expression of DBP mRNA		 CTD PMID:19162173, PMID:27413110, PMID:28903501 NCBI chr 1:101,687,896...101,692,845
Ensembl chr 1:101,687,855...101,692,846 		JBrowse link
G Dcaf11 DDB1 and CUL4 associated factor 11 increases expression EXP Pregnenolone Carbonitrile results in increased expression of DCAF11 mRNA CTD PMID:19162173 NCBI chr15:34,233,840...34,244,512
Ensembl chr15:34,234,193...34,244,504 		JBrowse link
G Dcdc2 doublecortin domain containing 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of DCDC2A mRNA CTD PMID:22698814 NCBI chr17:41,838,201...42,031,265
Ensembl chr17:41,838,201...42,031,265 		JBrowse link
G Dcun1d4 defective in cullin neddylation 1 domain containing 4 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DCUN1D4 mRNA CTD PMID:28903501 NCBI chr14:37,210,721...37,294,517
Ensembl chr14:37,210,721...37,294,472 		JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DDAH1 mRNA CTD PMID:28903501 NCBI chr 2:251,634,368...251,766,009
Ensembl chr 2:251,634,431...251,766,014 		JBrowse link
G Ddc dopa decarboxylase decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DDC mRNA CTD PMID:28903501 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO Pregnenolone Carbonitrile results in increased expression of DDIT4 mRNA CTD PMID:28903501 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382 		JBrowse link
G Ddx21 DExD-box helicase 21 increases expression ISO Pregnenolone Carbonitrile results in increased expression of DDX21 mRNA CTD PMID:28903501 NCBI chr20:32,213,147...32,232,632
Ensembl chr20:32,213,148...32,232,632 		JBrowse link
G Ddx27 DEAD-box helicase 27 increases expression ISO Pregnenolone Carbonitrile results in increased expression of DDX27 mRNA CTD PMID:28903501 NCBI chr 3:163,767,236...163,786,408
Ensembl chr 3:163,767,173...163,786,445 		JBrowse link
G Dennd2b DENN domain containing 2B increases expression ISO Pregnenolone Carbonitrile results in increased expression of DENN2B mRNA CTD PMID:28903501 NCBI chr 1:174,137,120...174,290,533
Ensembl chr 1:174,137,120...174,289,647 		JBrowse link
G Depdc7 DEP domain containing 7 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DEPDC7 mRNA CTD PMID:28903501 NCBI chr 3:94,665,714...94,687,013
Ensembl chr 3:94,665,717...94,686,989 		JBrowse link
G Derl3 derlin 3 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DERL3 mRNA CTD PMID:28903501 NCBI chr20:13,692,102...13,707,645
Ensembl chr20:13,704,314...13,706,205 		JBrowse link
G Desi2 desumoylating isopeptidase 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of DESI2 mRNA CTD PMID:28903501 NCBI chr13:96,111,800...96,156,693
Ensembl chr13:96,111,800...96,154,685 		JBrowse link
G Dexi Dexi homolog decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DEXI mRNA CTD PMID:28903501 NCBI chr10:5,199,226...5,211,913
Ensembl chr10:5,199,226...5,211,913 		JBrowse link
G Dgkg diacylglycerol kinase, gamma increases expression EXP Pregnenolone Carbonitrile results in increased expression of DGKG mRNA CTD PMID:19162173 NCBI chr11:81,971,585...82,165,111
Ensembl chr11:81,972,219...82,163,165 		JBrowse link
G Dgkz diacylglycerol kinase zeta decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of DGKZ mRNA CTD PMID:19162173 NCBI chr 3:80,844,002...80,886,487
Ensembl chr 3:80,844,005...80,875,817 		JBrowse link
G Dhdh dihydrodiol dehydrogenase decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DHDH mRNA CTD PMID:28903501 NCBI chr 1:101,465,937...101,476,867
Ensembl chr 1:101,466,677...101,476,867 		JBrowse link
G Dhrs1 dehydrogenase/reductase 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DHRS1 mRNA CTD PMID:28903501 NCBI chr15:34,424,017...34,431,302
Ensembl chr15:34,424,016...34,431,325 		JBrowse link
G Dhx36 DEAH-box helicase 36 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of DHX36 mRNA CTD PMID:19162173 NCBI chr 2:152,785,844...152,824,549
Ensembl chr 2:152,785,844...152,824,547 		JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of DIO1 mRNA CTD PMID:19162173 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520 		JBrowse link
G Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease increases expression ISO Pregnenolone Carbonitrile results in increased expression of DIS3 mRNA CTD PMID:28903501 NCBI chr15:83,466,330...83,494,107
Ensembl chr15:83,466,428...83,494,423 		JBrowse link
G Dis3l2 DIS3-like 3'-5' exoribonuclease 2 increases expression EXP Pregnenolone Carbonitrile results in increased expression of DIS3L2 mRNA CTD PMID:19162173 NCBI chr 9:93,767,837...94,161,106
Ensembl chr 9:93,660,680...94,160,760 		JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase increases expression EXP
ISO		 Pregnenolone Carbonitrile results in increased expression of DLAT mRNA CTD PMID:19162173, PMID:28903501 NCBI chr 8:55,062,549...55,087,832
Ensembl chr 8:55,062,551...55,087,832 		JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DLC1 mRNA CTD PMID:28903501 NCBI chr16:58,776,489...59,247,752
Ensembl chr16:59,077,574...59,247,754 		JBrowse link
G Dll1 delta like canonical Notch ligand 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of DLL1 mRNA CTD PMID:28903501 NCBI chr 1:57,318,621...57,326,732
Ensembl chr 1:57,318,708...57,327,379 		JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase increases expression ISO Pregnenolone Carbonitrile results in increased expression of DLST mRNA CTD PMID:28903501 NCBI chr 6:108,936,534...108,961,322
Ensembl chr 6:108,936,664...108,959,803 		JBrowse link
G Dmac2l distal membrane arm assembly complex 2 like increases expression EXP Pregnenolone Carbonitrile results in increased expression of DMAC2L mRNA CTD PMID:19162173 NCBI chr 6:92,057,782...92,076,022
Ensembl chr 6:92,057,807...92,076,021 		JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of DNAJA3 mRNA CTD PMID:28903501 NCBI chr10:11,059,701...11,085,186
Ensembl chr10:11,060,313...11,085,210 		JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression EXP Pregnenolone Carbonitrile results in increased expression of DNAJB9 mRNA CTD PMID:19162173, PMID:21318169 NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151 		JBrowse link
G Dnm3 dynamin 3 increases expression EXP Pregnenolone Carbonitrile results in increased expression of DNM3 mRNA CTD PMID:19162173 NCBI chr13:79,906,711...80,379,967
Ensembl chr13:79,910,382...80,379,929 		JBrowse link
G Dop1a DOP1 leucine zipper like protein A increases expression ISO Pregnenolone Carbonitrile results in increased expression of DOP1A mRNA CTD PMID:28903501 NCBI chr 8:94,122,733...94,225,131
Ensembl chr 8:94,122,728...94,225,031 		JBrowse link
G Dop1b DOP1 leucine zipper like protein B increases expression ISO Pregnenolone Carbonitrile results in increased expression of DOP1B mRNA CTD PMID:28903501 NCBI chr11:33,929,142...34,027,447
Ensembl chr11:33,925,498...34,027,435 		JBrowse link
G Dpp9 dipeptidyl peptidase 9 increases expression ISO Pregnenolone Carbonitrile results in increased expression of DPP9 mRNA CTD PMID:28903501 NCBI chr 9:10,846,493...10,882,560
Ensembl chr 9:10,846,596...10,882,649 		JBrowse link
G Drg1 developmentally regulated GTP binding protein 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of DRG1 mRNA CTD PMID:28903501 NCBI chr14:83,460,540...83,476,568
Ensembl chr14:83,460,540...83,476,568 		JBrowse link
G Dsc2 desmocollin 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DSC2 mRNA CTD PMID:28903501 NCBI chr18:11,826,705...11,858,801
Ensembl chr18:11,826,706...11,858,754 		JBrowse link
G Dsg2 desmoglein 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DSG2 mRNA CTD PMID:28903501 NCBI chr18:15,579,322...15,637,720
Ensembl chr18:15,579,315...15,637,715 		JBrowse link
G Dsp desmoplakin decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DSP mRNA CTD PMID:28903501 NCBI chr17:27,286,811...27,334,453
Ensembl chr17:27,286,796...27,334,379 		JBrowse link
G Dtx4 deltex E3 ubiquitin ligase 4 increases expression ISO Pregnenolone Carbonitrile results in increased expression of DTX4 mRNA CTD PMID:28903501 NCBI chr 1:228,729,842...228,759,783
Ensembl chr 1:228,732,985...228,755,866 		JBrowse link
G Dusp1 dual specificity phosphatase 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of DUSP1 mRNA CTD PMID:19162173 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418 		JBrowse link
G Dusp6 dual specificity phosphatase 6 affects expression EXP Pregnenolone Carbonitrile affects the expression of DUSP6 mRNA CTD PMID:19162173 NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392 		JBrowse link
G Dxo decapping exoribonuclease increases expression ISO Pregnenolone Carbonitrile results in increased expression of DXO mRNA CTD PMID:28903501 NCBI chr20:4,517,307...4,519,391
Ensembl chr20:4,517,307...4,519,389 		JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of DYNC1H1 mRNA CTD PMID:19162173 NCBI chr 6:134,958,854...135,085,769
Ensembl chr 6:134,958,854...135,085,769 		JBrowse link
G Dync2h1 dynein cytoplasmic 2 heavy chain 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of DYNC2H1 mRNA CTD PMID:19162173 NCBI chr 8:5,217,054...5,436,969
Ensembl chr 8:5,217,217...5,429,581 		JBrowse link
G Dynll2 dynein light chain LC8-type 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of DYNLL2 mRNA CTD PMID:28903501 NCBI chr10:75,262,536...75,281,302
Ensembl chr10:75,262,537...75,270,561 		JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of E2F1 mRNA CTD PMID:23626729 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721 		JBrowse link
G E2f2 E2F transcription factor 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of E2F2 mRNA CTD PMID:28903501 NCBI chr 5:154,516,611...154,540,228
Ensembl chr 5:154,522,119...154,540,265 		JBrowse link
G Ebna1bp2 EBNA1 binding protein 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of EBNA1BP2 mRNA CTD PMID:28903501 NCBI chr 5:137,458,692...137,463,255
Ensembl chr 5:137,670,123...137,674,802 		JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of ECH1 mRNA CTD PMID:19162173 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005 		JBrowse link
G Echdc3 enoyl CoA hydratase domain containing 3 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ECHDC3 mRNA CTD PMID:28903501 NCBI chr17:76,002,304...76,022,813
Ensembl chr17:76,002,275...76,022,813 		JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ECHS1 mRNA CTD PMID:19162173 NCBI chr 1:212,570,213...212,579,040
Ensembl chr 1:212,570,195...212,579,057 		JBrowse link
G Eef1b2 eukaryotic translation elongation factor 1 beta 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of EEF1B2 mRNA CTD PMID:28903501 NCBI chr 9:69,953,440...69,956,158
Ensembl chr 9:69,953,440...69,956,160 		JBrowse link
G Eef2k eukaryotic elongation factor-2 kinase decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of EEF2K mRNA CTD PMID:28903501 NCBI chr 1:190,780,211...190,839,926
Ensembl chr 1:190,780,236...190,842,324 		JBrowse link
G Efna3 ephrin A3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of EFNA3 mRNA CTD PMID:28903501 NCBI chr 2:188,636,304...188,645,302
Ensembl chr 2:188,637,852...188,645,196 		JBrowse link
G Egfl7 EGF-like-domain, multiple 7 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of EGFL7 mRNA CTD PMID:19162173 NCBI chr 3:4,034,759...4,044,280
Ensembl chr 3:4,034,921...4,043,936 		JBrowse link
G Egr1 early growth response 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of EGR1 mRNA CTD PMID:19162173 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429 		JBrowse link
G Egr2 early growth response 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of EGR2 mRNA CTD PMID:22698814 NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025 		JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of EHHADH mRNA CTD PMID:19162173 NCBI chr11:82,945,104...82,978,364
Ensembl chr11:82,945,104...82,978,364 		JBrowse link
G Eif3h eukaryotic translation initiation factor 3, subunit H increases expression ISO Pregnenolone Carbonitrile results in increased expression of EIF3H mRNA CTD PMID:28903501 NCBI chr 6:10,151,732...10,236,677 JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of EIF4A1 mRNA CTD PMID:28903501 NCBI chr10:56,271,257...56,276,764
Ensembl chr10:56,271,257...56,276,764 		JBrowse link
G Eif4a2 eukaryotic translation initiation factor 4A2 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of EIF4A2 mRNA CTD PMID:19162173 NCBI chr11:81,373,047...81,379,680
Ensembl chr11:81,373,048...81,379,871 		JBrowse link
G Eif4ebp3 eukaryotic translation initiation factor 4E binding protein 3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of EIF4EBP3 mRNA CTD PMID:28903501 NCBI chr18:29,490,981...29,492,727
Ensembl chr18:29,386,809...29,492,718 		JBrowse link
G Elfn1 extracellular leucine-rich repeat and fibronectin type III domain containing 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ELFN1 mRNA CTD PMID:22698814 NCBI chr12:16,749,340...16,813,838
Ensembl chr12:16,749,374...16,813,838 		JBrowse link
G Elovl3 ELOVL fatty acid elongase 3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ELOVL3 mRNA CTD PMID:28903501 NCBI chr 1:265,883,353...265,887,181
Ensembl chr 1:265,883,355...265,887,226 		JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ELOVL5 mRNA CTD PMID:28903501 NCBI chr 8:85,220,941...85,287,449
Ensembl chr 8:85,259,982...85,285,983 		JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ELOVL6 mRNA CTD PMID:28903501 NCBI chr 2:234,187,490...234,296,124
Ensembl chr 2:234,189,105...234,296,145
Ensembl chr 2:234,189,105...234,296,145 		JBrowse link
G Elovl7 ELOVL fatty acid elongase 7 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ELOVL7 mRNA CTD PMID:22698814 NCBI chr 2:40,373,211...40,386,643
Ensembl chr 2:40,373,211...40,386,669 		JBrowse link
G Emb embigin decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of EMB mRNA CTD PMID:22698814 NCBI chr 2:49,682,763...49,733,475
Ensembl chr 2:49,682,754...49,732,253 		JBrowse link
G Emilin2 elastin microfibril interfacer 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of EMILIN2 mRNA CTD PMID:22698814 NCBI chr 9:119,594,049...119,653,675
Ensembl chr 9:119,594,629...119,653,255 		JBrowse link
G Enho energy homeostasis associated decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ENHO mRNA CTD PMID:28903501 NCBI chr 5:58,018,039...58,019,836
Ensembl chr 5:58,018,039...58,019,836 		JBrowse link
G Enpp6 ectonucleotide pyrophosphatase/phosphodiesterase 6 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ENPP6 mRNA CTD PMID:28903501 NCBI chr16:48,315,500...48,437,258
Ensembl chr16:48,315,914...48,437,242 		JBrowse link
G Entpd2 ectonucleoside triphosphate diphosphohydrolase 2 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ENTPD2 mRNA CTD PMID:19162173 NCBI chr 3:2,617,795...2,623,818
Ensembl chr 3:2,617,805...2,623,445 		JBrowse link
G Epas1 endothelial PAS domain protein 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of EPAS1 mRNA CTD PMID:28903501 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265 		JBrowse link
G Epb41 erythrocyte membrane protein band 4.1 increases expression EXP
ISO		 Pregnenolone Carbonitrile results in increased expression of EPB41 mRNA CTD PMID:19162173, PMID:28903501 NCBI chr 5:150,081,727...150,243,186
Ensembl chr 5:150,084,611...150,167,077 		JBrowse link
G Epcam epithelial cell adhesion molecule increases expression EXP Pregnenolone Carbonitrile results in increased expression of EPCAM mRNA CTD PMID:19162173 NCBI chr 6:11,282,194...11,308,870
Ensembl chr 6:11,281,964...11,298,216 		JBrowse link
G Epha1 Eph receptor A1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of EPHA1 mRNA CTD PMID:28903501 NCBI chr 4:71,749,100...71,763,681
Ensembl chr 4:71,749,242...71,763,679 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression
multiple interactions		 EXP
ISO		 Pregnenolone Carbonitrile results in increased expression of EPHX1 mRNA
[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in increased expression of EPHX1 mRNA		 CTD PMID:19162173, PMID:20359477, PMID:27413110 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579 		JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of EPHX2 mRNA CTD PMID:27413110 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279 		JBrowse link
G Eppk1 epiplakin 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of EPPK1 mRNA CTD PMID:28903501 NCBI chr 7:117,163,383...117,173,741 JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of ERN1 mRNA CTD PMID:19162173 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914 		JBrowse link
G Ero1b endoplasmic reticulum oxidoreductase 1 beta decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ERO1B mRNA CTD PMID:28903501 NCBI chr17:90,709,394...90,783,110
Ensembl chr17:90,710,555...90,756,048 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 increases expression EXP Pregnenolone Carbonitrile results in increased expression of ERP29 mRNA CTD PMID:19162173, PMID:21318169 NCBI chr12:40,619,377...40,625,884
Ensembl chr12:40,619,377...40,625,883 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ERRFI1 mRNA CTD PMID:28903501 NCBI chr 5:167,951,564...167,966,011
Ensembl chr 5:167,952,728...167,966,009 		JBrowse link
G Esam endothelial cell adhesion molecule increases expression ISO Pregnenolone Carbonitrile results in increased expression of ESAM mRNA CTD PMID:28903501 NCBI chr 8:39,997,875...40,008,802
Ensembl chr 8:39,997,875...40,008,809 		JBrowse link
G Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ESCO2 mRNA CTD PMID:22698814 NCBI chr15:42,500,929...42,519,019
Ensembl chr15:42,500,929...42,518,855 		JBrowse link
G Esrra estrogen related receptor, alpha increases expression EXP Pregnenolone Carbonitrile results in increased expression of ESRRA mRNA CTD PMID:19162173 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725 		JBrowse link
G Etl4 enhancer trap locus 4 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ETL4 mRNA CTD PMID:28903501 NCBI chr17:87,173,265...87,681,268
Ensembl chr17:87,274,944...87,681,317 		JBrowse link
G Etnk2 ethanolamine kinase 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of ETNK2 mRNA CTD PMID:28903501 NCBI chr13:50,481,178...50,498,991
Ensembl chr13:50,481,163...50,499,140 		JBrowse link
G Etnppl ethanolamine-phosphate phospho-lyase decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of ETNPPL mRNA CTD PMID:27413110 NCBI chr 2:235,738,377...235,760,351
Ensembl chr 2:235,738,416...235,760,352 		JBrowse link
G Exo1 exonuclease 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of EXO1 mRNA CTD PMID:22698814 NCBI chr13:93,936,989...93,962,749
Ensembl chr13:93,939,022...93,960,342 		JBrowse link
G Exosc1 exosome component 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of EXOSC1 mRNA CTD PMID:28903501 NCBI chr 1:261,169,798...261,179,865
Ensembl chr 1:261,170,229...261,179,790 		JBrowse link
G Exosc2 exosome component 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of EXOSC2 mRNA CTD PMID:28903501 NCBI chr 3:10,151,734...10,161,997
Ensembl chr 3:10,151,284...10,161,989 		JBrowse link
G Exosc8 exosome component 8 increases expression ISO Pregnenolone Carbonitrile results in increased expression of EXOSC8 mRNA CTD PMID:28903501 NCBI chr 2:143,925,643...143,932,240
Ensembl chr 2:143,925,546...143,931,940 		JBrowse link
G Exph5 exophilin 5 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of EXPH5 mRNA CTD PMID:28903501 NCBI chr 8:57,885,932...57,962,574
Ensembl chr 8:57,886,168...57,962,708 		JBrowse link
G F10 coagulation factor X decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of F10 mRNA CTD PMID:19162173 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716 		JBrowse link
G Faah fatty acid amide hydrolase decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of FAAH mRNA CTD PMID:28903501 NCBI chr 5:134,852,899...134,872,095
Ensembl chr 5:134,852,875...134,871,775 		JBrowse link
G Faahl fatty-acid amide hydrolase-like decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of FAAH mRNA CTD PMID:28903501 NCBI chr 5:134,330,204...134,349,400
Ensembl chr 5:134,331,929...134,348,995 		JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of FABP1 mRNA CTD PMID:28903501 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954 		JBrowse link
G Fabp2 fatty acid binding protein 2 increases expression EXP Pregnenolone Carbonitrile results in increased expression of FABP2 mRNA CTD PMID:19162173 NCBI chr 2:227,080,912...227,083,654
Ensembl chr 2:227,080,924...227,083,501 		JBrowse link
G Fabp5 fatty acid binding protein 5 decreases expression
increases expression		 EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of FABP5 mRNA
Pregnenolone Carbonitrile results in increased expression of FABP5 mRNA		 CTD PMID:19162173, PMID:28903501 NCBI chr 2:93,981,662...93,985,322
Ensembl chr 2:93,981,656...93,985,378 		JBrowse link
G Fads2 fatty acid desaturase 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of FADS2 mRNA CTD PMID:28903501 NCBI chr 1:225,906,582...226,152,568
Ensembl chr 1:226,114,413...226,152,524 		JBrowse link
G Fads3 fatty acid desaturase 3 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of FADS3 mRNA CTD PMID:28903501 NCBI chr 1:226,091,774...226,108,332
Ensembl chr 1:226,091,774...226,108,332 		JBrowse link
G Fads6 fatty acid desaturase 6 increases expression ISO Pregnenolone Carbonitrile results in increased expression of FADS6 mRNA CTD PMID:20359477 NCBI chr10:103,832,838...103,848,035
Ensembl chr10:103,832,838...103,848,035 		JBrowse link
G Fahd1 fumarylacetoacetate hydrolase domain containing 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of FAHD1 mRNA CTD PMID:28903501 NCBI chr10:14,214,518...14,215,957
Ensembl chr10:14,214,519...14,215,957 		JBrowse link
G Fam102a family with sequence similarity 102, member A decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of FAM102A mRNA CTD PMID:28903501 NCBI chr 3:11,554,084...11,586,315
Ensembl chr 3:11,554,457...11,586,303 		JBrowse link
G Fam149a family with sequence similarity 149, member A decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of FAM149A mRNA CTD PMID:28903501 NCBI chr16:50,049,816...50,105,962
Ensembl chr16:50,049,828...50,107,856 		JBrowse link
G Fam189a2 family with sequence similarity 189, member A2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of FAM189A2 mRNA CTD PMID:22698814 NCBI chr 1:241,822,152...241,876,089
Ensembl chr 1:241,822,626...241,875,864 		JBrowse link
G Fam20c FAM20C, golgi associated secretory pathway kinase decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of FAM20C mRNA CTD PMID:28903501 NCBI chr12:17,913,771...17,972,733
Ensembl chr12:17,913,767...17,972,737 		JBrowse link
G Fam78b family with sequence similarity 78, member B decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of FAM78B mRNA CTD PMID:22698814 NCBI chr13:85,110,536...85,233,243
Ensembl chr13:85,110,098...85,231,155 		JBrowse link
G Fanca FA complementation group A increases expression ISO Pregnenolone Carbonitrile results in increased expression of FANCA mRNA CTD PMID:22698814 NCBI chr19:56,067,548...56,126,075
Ensembl chr19:56,067,548...56,126,063 		JBrowse link
G Fancg FA complementation group G increases expression ISO Pregnenolone Carbonitrile results in increased expression of FANCG mRNA CTD PMID:22698814 NCBI chr 5:58,448,060...58,456,416
Ensembl chr 5:58,448,822...58,455,819 		JBrowse link
G Fanci FA complementation group I increases expression ISO Pregnenolone Carbonitrile results in increased expression of FANCI mRNA CTD PMID:22698814 NCBI chr 1:141,116,565...141,172,997
Ensembl chr 1:141,120,166...141,172,483 		JBrowse link
G Farp1 FERM, ARH/RhoGEF and pleckstrin domain protein 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of FARP1 mRNA CTD PMID:28903501 NCBI chr15:106,375,298...106,625,837
Ensembl chr15:106,434,177...106,625,837 		JBrowse link
G Fas Fas cell surface death receptor decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of FAS mRNA CTD PMID:19162173 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Fasn fatty acid synthase decreases expression
multiple interactions
increases expression		 EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of FASN mRNA
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of FASN mRNA]
Pregnenolone Carbonitrile results in increased expression of FASN mRNA		 CTD PMID:19162173, PMID:20359477 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G Fbf1 Fas binding factor 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of FBF1 mRNA CTD PMID:28903501 NCBI chr10:104,692,791...104,718,630
Ensembl chr10:104,692,755...104,718,621 		JBrowse link
G Fbxo21 F-box protein 21 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of FBXO21 mRNA CTD PMID:28903501 NCBI chr12:44,244,633...44,279,044
Ensembl chr12:44,246,508...44,279,002 		JBrowse link
G Fbxo31 F-box protein 31 increases expression ISO Pregnenolone Carbonitrile results in increased expression of FBXO31 mRNA CTD PMID:28903501 NCBI chr19:53,487,610...53,625,673
Ensembl chr19:53,487,613...53,625,673 		JBrowse link
G Fbxo44 F-box protein 44 increases expression ISO Pregnenolone Carbonitrile results in increased expression of FBXO44 mRNA CTD PMID:22698814 NCBI chr 5:164,962,921...164,972,273
Ensembl chr 5:164,963,433...164,971,903 		JBrowse link
G Fcgr2a Fc fragment of IgG receptor IIa decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of FCGR2A mRNA CTD PMID:19162173 NCBI chr13:91,146,878...91,163,691
Ensembl chr13:91,168,973...91,198,036
Ensembl chr13:91,168,973...91,198,036 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of FDFT1 mRNA CTD PMID:28903501 NCBI chr15:46,339,248...46,367,302
Ensembl chr15:46,339,249...46,367,302 		JBrowse link
G Fdps farnesyl diphosphate synthase decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of FDPS mRNA CTD PMID:28903501 NCBI chr 2:188,403,595...188,413,219
Ensembl chr 2:188,392,858...188,413,219 		JBrowse link
G Fdx1 ferredoxin 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of FDX1 mRNA CTD PMID:28903501 NCBI chr 8:56,373,729...56,393,199
Ensembl chr 8:56,373,723...56,393,233 		JBrowse link
G Fga fibrinogen alpha chain decreases expression
increases expression		 EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of FGA mRNA
Pregnenolone Carbonitrile results in increased expression of FGA mRNA		 CTD PMID:19162173, PMID:28903501 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763 		JBrowse link
G Fgb fibrinogen beta chain increases expression ISO Pregnenolone Carbonitrile results in increased expression of FGB mRNA CTD PMID:28903501 NCBI chr 2:182,028,044...182,035,026
Ensembl chr 2:182,027,115...182,038,178 		JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression EXP
ISO		 Pregnenolone Carbonitrile results in increased expression of FGF1 mRNA CTD PMID:19162173, PMID:28903501 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824 		JBrowse link
G Fgf21 fibroblast growth factor 21 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of FGF21 mRNA CTD PMID:22698814, PMID:28903501 NCBI chr 1:101,595,579...101,596,822
Ensembl chr 1:101,595,579...101,596,822 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of FGFR4 mRNA CTD PMID:28903501 NCBI chr17:9,990,072...10,004,339
Ensembl chr17:9,990,078...10,004,321 		JBrowse link
G Fgfrl1 fibroblast growth factor receptor-like 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of FGFRL1 mRNA CTD PMID:28903501 NCBI chr14:2,020,110...2,032,169
Ensembl chr14:2,018,500...2,032,593 		JBrowse link
G Fgg fibrinogen gamma chain increases expression ISO Pregnenolone Carbonitrile results in increased expression of FGG mRNA CTD PMID:28903501 NCBI chr 2:181,987,080...181,994,523
Ensembl chr 2:181,987,217...181,994,514 		JBrowse link
G Fgl1 fibrinogen-like 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of FGL1 mRNA CTD PMID:28903501 NCBI chr16:54,153,086...54,188,120
Ensembl chr16:54,153,054...54,188,181 		JBrowse link
G Fh fumarate hydratase increases expression ISO Pregnenolone Carbonitrile results in increased expression of FH1 mRNA CTD PMID:28903501 NCBI chr13:93,651,486...93,677,371
Ensembl chr13:93,651,484...93,677,377 		JBrowse link
G Fign fidgetin, microtubule severing factor decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of FIGN mRNA CTD PMID:28903501 NCBI chr 3:49,992,250...50,120,601
Ensembl chr 3:49,992,397...50,120,392 		JBrowse link
G Fkbp11 FKBP prolyl isomerase 11 increases expression EXP Pregnenolone Carbonitrile results in increased expression of FKBP11 mRNA CTD PMID:19162173, PMID:21318169 NCBI chr 7:140,398,253...140,402,664
Ensembl chr 7:140,398,199...140,437,467 		JBrowse link
G Fkbp14 FKBP prolyl isomerase 14 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of FKBP14 mRNA CTD PMID:28903501 NCBI chr 4:84,753,628...84,768,314
Ensembl chr 4:84,753,633...84,768,249 		JBrowse link
G Fkbp2 FKBP prolyl isomerase 2 increases expression EXP Pregnenolone Carbonitrile results in increased expression of FKBP2 mRNA CTD PMID:19162173 NCBI chr 1:222,232,349...222,235,113
Ensembl chr 1:222,232,351...222,235,102 		JBrowse link
G Fkbp4 FKBP prolyl isomerase 4 affects expression
increases expression		 EXP Pregnenolone Carbonitrile affects the expression of FKBP4 mRNA
Pregnenolone Carbonitrile results in increased expression of FKBP4 mRNA		 CTD PMID:19162173, PMID:21318169 NCBI chr 4:161,748,993...161,757,447
Ensembl chr 4:161,748,993...161,757,447 		JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 increases expression ISO Pregnenolone Carbonitrile results in increased expression of FKBP5 mRNA CTD PMID:28903501 NCBI chr20:7,976,704...8,097,290
Ensembl chr20:7,976,713...8,019,020 		JBrowse link
G Flcn folliculin increases expression ISO Pregnenolone Carbonitrile results in increased expression of FLCN mRNA CTD PMID:28903501 NCBI chr10:46,153,185...46,172,331
Ensembl chr10:46,153,188...46,172,309 		JBrowse link
G Flot2 flotillin 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of FLOT2 mRNA CTD PMID:28903501 NCBI chr10:65,304,901...65,329,332
Ensembl chr10:65,304,902...65,329,312 		JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 decreases expression EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of FMO1 mRNA CTD PMID:19162173, PMID:27413110, PMID:28903501 NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347 		JBrowse link
G Fmo4 flavin containing dimethylaniline monoxygenase 4 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of FMO4 mRNA CTD PMID:28903501 NCBI chr13:80,685,385...80,703,575
Ensembl chr13:80,685,325...80,703,615 		JBrowse link
G Fn1 fibronectin 1 decreases expression
increases expression		 EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of FN1 mRNA
Pregnenolone Carbonitrile results in increased expression of FN1 mRNA		 CTD PMID:19162173, PMID:28903501 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078 		JBrowse link
G Fn3k fructosamine 3 kinase decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of FN3K mRNA CTD PMID:28903501 NCBI chr10:110,626,462...110,642,262
Ensembl chr10:110,631,494...110,642,260 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions		 ISO Pregnenolone Carbonitrile results in decreased expression of FOS mRNA
NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in decreased expression of FOS mRNA]		 CTD PMID:22698814 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit increases expression ISO Pregnenolone Carbonitrile results in increased expression of FOSL2 mRNA CTD PMID:28903501 NCBI chr 6:25,598,936...25,616,995
Ensembl chr 6:25,598,936...25,616,995 		JBrowse link
G Foxk2 forkhead box K2 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of FOXK2 mRNA CTD PMID:19162173 NCBI chr10:110,468,905...110,518,854
Ensembl chr10:110,469,290...110,518,848 		JBrowse link
G Foxm1 forkhead box M1 increases expression
multiple interactions		 ISO Pregnenolone Carbonitrile results in increased expression of FOXM1 mRNA
NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of FOXM1 mRNA]		 CTD PMID:22698814 NCBI chr 4:161,685,236...161,697,633
Ensembl chr 4:161,685,258...161,696,305 		JBrowse link
G Foxo1 forkhead box O1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of FOXO1 mRNA CTD PMID:28903501 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016 		JBrowse link
G Fst follistatin decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of FST mRNA CTD PMID:28903501 NCBI chr 2:46,537,589...46,544,813
Ensembl chr 2:46,538,700...46,544,457 		JBrowse link
G Ftsj3 FtsJ RNA 2'-O-methyltransferase 3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of FTSJ3 mRNA CTD PMID:28903501 NCBI chr10:94,439,059...94,445,503
Ensembl chr10:94,439,077...94,445,503 		JBrowse link
G Fuom fucose mutarotase increases expression ISO Pregnenolone Carbonitrile results in increased expression of FUOM mRNA CTD PMID:28903501 NCBI chr 1:212,563,714...212,568,224
Ensembl chr 1:212,563,714...212,568,224 		JBrowse link
G Fxyd5 FXYD domain-containing ion transport regulator 5 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of FXYD5 mRNA CTD PMID:22698814 NCBI chr 1:89,464,853...89,474,450
Ensembl chr 1:89,464,860...89,474,252 		JBrowse link
G Fzd3 frizzled class receptor 3 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of FZD3 mRNA CTD PMID:22698814 NCBI chr15:48,601,259...48,670,257
Ensembl chr15:48,601,266...48,670,257 		JBrowse link
G G0s2 G0/G1switch 2 increases expression
decreases expression		 ISO Pregnenolone Carbonitrile results in increased expression of G0S2 mRNA
Pregnenolone Carbonitrile results in decreased expression of G0S2 mRNA		 CTD PMID:27413110, PMID:28903501 NCBI chr13:112,004,140...112,005,052
Ensembl chr13:112,004,140...112,005,052 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 affects expression EXP Pregnenolone Carbonitrile affects the expression of G6PC mRNA CTD PMID:19162173 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213 		JBrowse link
G Gaa glucosidase, alpha, acid increases expression EXP Pregnenolone Carbonitrile results in increased expression of GAA mRNA CTD PMID:19162173 NCBI chr10:108,395,873...108,412,999
Ensembl chr10:108,395,860...108,413,059 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression
multiple interactions		 EXP
ISO		 Pregnenolone Carbonitrile results in increased expression of GADD45A mRNA
[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Pregnenolone Carbonitrile] results in increased expression of GADD45A mRNA		 CTD PMID:19162173, PMID:23626729, PMID:28903501 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO Pregnenolone Carbonitrile results in increased expression of GADD45B mRNA CTD PMID:27413110, PMID:28903501 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322 		JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression ISO Pregnenolone Carbonitrile results in increased expression of GADD45G mRNA CTD PMID:28903501 NCBI chr17:13,391,474...13,393,219
Ensembl chr17:13,391,467...13,393,243 		JBrowse link
G Gale UDP-galactose-4-epimerase decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of GALE mRNA CTD PMID:28903501 NCBI chr 5:154,310,453...154,314,959
Ensembl chr 5:154,310,453...154,314,955 		JBrowse link
G Galnt2 polypeptide N-acetylgalactosaminyltransferase 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of GALNT2 mRNA CTD PMID:28903501 NCBI chr19:57,043,858...57,115,123
Ensembl chr19:57,047,830...57,115,132 		JBrowse link
G Gamt guanidinoacetate N-methyltransferase decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of GAMT mRNA CTD PMID:28903501 NCBI chr 7:12,314,848...12,317,998
Ensembl chr 7:12,314,848...12,317,998 		JBrowse link
G Gar1 GAR1 ribonucleoprotein increases expression ISO Pregnenolone Carbonitrile results in increased expression of GAR1 mRNA CTD PMID:28903501 NCBI chr 2:235,250,453...235,258,464
Ensembl chr 2:235,250,453...235,257,731 		JBrowse link
G Gas2l1 growth arrest-specific 2 like 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of GAS2L1 mRNA CTD PMID:22698814 NCBI chr14:85,308,443...85,318,475
Ensembl chr14:85,308,443...85,318,194 		JBrowse link
G Gas2l3 growth arrest-specific 2 like 3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of GAS2L3 mRNA CTD PMID:22698814 NCBI chr 7:29,963,129...29,996,021
Ensembl chr 7:29,959,597...29,986,163 		JBrowse link
G Gas5 growth arrest specific 5 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of GAS5 mRNA CTD PMID:19162173 NCBI chr13:78,852,523...78,855,844 JBrowse link
G Gas6 growth arrest specific 6 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of GAS6 mRNA CTD PMID:19162173 NCBI chr16:81,213,364...81,243,824
Ensembl chr16:81,213,364...81,243,757 		JBrowse link
G Gas7 growth arrest specific 7 increases expression ISO Pregnenolone Carbonitrile results in increased expression of GAS7 mRNA CTD PMID:22698814 NCBI chr10:54,010,723...54,240,805
Ensembl chr10:54,126,486...54,236,476 		JBrowse link
G Gcc2 GRIP and coiled-coil domain containing 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of GCC2 mRNA CTD PMID:22698814 NCBI chr20:27,832,960...27,879,764
Ensembl chr20:27,832,932...27,879,759 		JBrowse link
G Gch1 GTP cyclohydrolase 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of GCH1 mRNA CTD PMID:19162173 NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011 		JBrowse link
G Gck glucokinase decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of GCK protein CTD PMID:26616219 NCBI chr14:86,149,146...86,191,589
Ensembl chr14:86,148,928...86,190,659 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
decreases expression		 EXP
ISO		 Pregnenolone Carbonitrile results in increased expression of GCLC mRNA
Pregnenolone Carbonitrile results in decreased expression of GCLC mRNA		 CTD PMID:19162173, PMID:28903501 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression EXP Pregnenolone Carbonitrile results in increased expression of GCLM mRNA CTD PMID:19162173 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874 		JBrowse link
G Gda guanine deaminase increases expression EXP Pregnenolone Carbonitrile results in increased expression of GDA mRNA CTD PMID:19162173 NCBI chr 1:238,982,542...239,057,663
Ensembl chr 1:238,982,392...239,057,732 		JBrowse link
G Gde1 glycerophosphodiester phosphodiesterase 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of GDE1 mRNA CTD PMID:19162173 NCBI chr 1:188,367,550...188,407,125
Ensembl chr 1:188,394,814...188,407,132 		JBrowse link
G Gfra1 GDNF family receptor alpha 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of GFRA1 mRNA CTD PMID:28903501 NCBI chr 1:279,203,046...279,572,789 JBrowse link
G Ggact gamma-glutamylamine cyclotransferase decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of GGACT mRNA CTD PMID:28903501 NCBI chr15:109,307,683...109,336,779
Ensembl chr15:109,307,904...109,316,953 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of GGT1 mRNA CTD PMID:19162173 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068 		JBrowse link
G Ghr growth hormone receptor decreases expression EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of GHR mRNA CTD PMID:19162173, PMID:28903501 NCBI chr 2:53,149,225...53,413,954
Ensembl chr 2:53,150,370...53,413,638 		JBrowse link
G Ghsr growth hormone secretagogue receptor increases expression EXP Pregnenolone Carbonitrile results in increased expression of GHSR mRNA CTD PMID:19162173 NCBI chr 2:113,065,953...113,071,265
Ensembl chr 2:113,066,885...113,070,261 		JBrowse link
G Gin1 gypsy retrotransposon integrase 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of GIN1 mRNA CTD PMID:28903501 NCBI chr 9:111,200,285...111,220,738
Ensembl chr 9:111,199,141...111,220,693 		JBrowse link
G Gins2 GINS complex subunit 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of GINS2 mRNA CTD PMID:22698814 NCBI chr19:54,151,048...54,163,701
Ensembl chr19:54,151,048...54,163,608 		JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of GJA1 mRNA CTD PMID:28903501 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089 		JBrowse link
G Gja4 gap junction protein, alpha 4 increases expression ISO Pregnenolone Carbonitrile results in increased expression of GJA4 mRNA CTD PMID:28903501 NCBI chr 5:145,374,688...145,377,221
Ensembl chr 5:145,374,690...145,377,221 		JBrowse link
G Gjb4 gap junction protein, beta 4 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of GJB4 mRNA CTD PMID:28903501 NCBI chr 5:145,416,343...145,421,122
Ensembl chr 5:145,416,343...145,418,992 		JBrowse link
G Glipr2 GLI pathogenesis-related 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of GLIPR2 mRNA CTD PMID:22698814 NCBI chr 5:59,415,415...59,446,732
Ensembl chr 5:59,416,076...59,446,647 		JBrowse link
G Gls2 glutaminase 2 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of GLS2 mRNA CTD PMID:19162173 NCBI chr 7:2,605,679...2,621,853
Ensembl chr 7:2,605,719...2,621,852 		JBrowse link
G Glt1d1 glycosyltransferase 1 domain containing 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of GLT1D1 mRNA CTD PMID:28903501 NCBI chr12:32,666,664...32,749,617
Ensembl chr12:32,666,635...32,740,732 		JBrowse link
G Glud1 glutamate dehydrogenase 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of GLUD1 mRNA CTD PMID:19162173 NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557 		JBrowse link
G Glul glutamate-ammonia ligase decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of GLUL mRNA CTD PMID:19162173 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229 		JBrowse link
G Gmfb glia maturation factor, beta increases expression EXP Pregnenolone Carbonitrile results in increased expression of GMFB mRNA CTD PMID:19162173 NCBI chr15:23,597,846...23,611,541
Ensembl chr15:23,601,368...23,606,634 		JBrowse link
G Gnao1 G protein subunit alpha o1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of GNAO1 mRNA CTD PMID:19162173 NCBI chr19:11,513,201...11,669,578
Ensembl chr19:11,513,201...11,669,578 		JBrowse link
G Gnas GNAS complex locus increases expression ISO Pregnenolone Carbonitrile results in increased expression of GNAS mRNA CTD PMID:22698814 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483 		JBrowse link
G Gnb5 G protein subunit beta 5 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of GNB5 mRNA CTD PMID:19162173 NCBI chr 8:82,248,951...82,286,493
Ensembl chr 8:82,257,849...82,285,184 		JBrowse link
G Gne glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of GNE mRNA CTD PMID:19162173 NCBI chr 5:59,511,738...59,553,421
Ensembl chr 5:59,512,872...59,553,416 		JBrowse link
G Gnl2 G protein nucleolar 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of GNL2 mRNA CTD PMID:28903501 NCBI chr 5:143,027,970...143,053,418
Ensembl chr 5:143,027,977...143,055,190 		JBrowse link
G Gnl3 G protein nucleolar 3 increases expression ISO Pregnenolone Carbonitrile results in increased expression of GNL3 mRNA CTD PMID:28903501 NCBI chr16:7,097,580...7,103,518
Ensembl chr16:7,097,507...7,103,604 		JBrowse link
G Gnmt glycine N-methyltransferase decreases expression
increases expression		 EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of GNMT mRNA
Pregnenolone Carbonitrile results in increased expression of GNMT mRNA		 CTD PMID:19162173, PMID:28903501 NCBI chr 9:16,565,274...16,568,626
Ensembl chr 9:16,565,225...16,568,627 		JBrowse link
G Gnpda1 glucosamine-6-phosphate deaminase 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of GNPDA1 mRNA CTD PMID:28903501 NCBI chr18:31,479,117...31,489,154
Ensembl chr18:31,479,117...31,487,671 		JBrowse link
G Golph3l golgi phosphoprotein 3-like increases expression ISO Pregnenolone Carbonitrile results in increased expression of GOLPH3L mRNA CTD PMID:22698814 NCBI chr 2:197,720,259...197,749,060
Ensembl chr 2:197,715,761...197,750,115 		JBrowse link
G Gorasp1 golgi reassembly stacking protein 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of GORASP1 mRNA CTD PMID:28903501 NCBI chr 8:128,610,290...128,622,337
Ensembl chr 8:128,610,291...128,622,337 		JBrowse link
G Gosr2 golgi SNAP receptor complex member 2 increases expression EXP Pregnenolone Carbonitrile results in increased expression of GOSR2 mRNA CTD PMID:19162173 NCBI chr10:91,735,772...91,756,123
Ensembl chr10:91,736,780...91,756,081 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 decreases expression
increases expression		 EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of GOT1 mRNA
Pregnenolone Carbonitrile results in increased expression of GOT1 mRNA		 CTD PMID:19162173, PMID:28903501 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of GPAM mRNA CTD PMID:28903501 NCBI chr 1:275,843,823...275,906,880
Ensembl chr 1:275,846,819...275,906,686 		JBrowse link
G Gpatch4 G patch domain containing 4 increases expression ISO Pregnenolone Carbonitrile results in increased expression of GPATCH4 mRNA CTD PMID:28903501 NCBI chr 2:187,404,731...187,424,047
Ensembl chr 2:187,415,262...187,424,045 		JBrowse link
G Gpc4 glypican 4 increases expression ISO Pregnenolone Carbonitrile results in increased expression of GPC4 mRNA CTD PMID:28903501 NCBI chr  X:139,354,325...139,464,876
Ensembl chr  X:139,354,155...139,464,798 		JBrowse link
G Gpcpd1 glycerophosphocholine phosphodiesterase 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of GPCPD1 mRNA CTD PMID:28903501 NCBI chr 3:125,169,131...125,213,598
Ensembl chr 3:125,169,135...125,213,607 		JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of GPD1 mRNA CTD PMID:28903501 NCBI chr 7:141,368,928...141,377,931
Ensembl chr 7:141,370,491...141,377,928 		JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of GPD2 mRNA CTD PMID:19162173 NCBI chr 3:43,223,892...43,359,069
Ensembl chr 3:43,255,567...43,359,074 		JBrowse link
G Gpt2 glutamic--pyruvic transaminase 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of GPT2 mRNA CTD PMID:27413110 NCBI chr19:22,599,003...22,633,529
Ensembl chr19:22,590,881...22,632,071 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of GPX1 mRNA CTD PMID:19162173 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression EXP Pregnenolone Carbonitrile results in increased expression of GPX2 mRNA CTD PMID:19162173 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245 		JBrowse link
G Gpx7 glutathione peroxidase 7 increases expression ISO Pregnenolone Carbonitrile results in increased expression of GPX7 mRNA CTD PMID:22698814 NCBI chr 5:128,001,766...128,009,610
Ensembl chr 5:128,001,761...128,009,735 		JBrowse link
G Grb2 growth factor receptor bound protein 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of GRB2 mRNA CTD PMID:28903501 NCBI chr10:104,193,953...104,263,071
Ensembl chr10:104,193,955...104,263,071 		JBrowse link
G Grb7 growth factor receptor bound protein 7 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of GRB7 mRNA CTD PMID:28903501 NCBI chr10:86,393,186...86,408,893
Ensembl chr10:86,399,827...86,409,348 		JBrowse link
G Grin3a glutamate ionotropic receptor NMDA type subunit 3A increases expression EXP Pregnenolone Carbonitrile results in increased expression of GRIN3A mRNA CTD PMID:19162173 NCBI chr 5:64,928,620...65,073,012
Ensembl chr 5:64,928,620...65,073,012 		JBrowse link
G Grk5 G protein-coupled receptor kinase 5 increases expression EXP Pregnenolone Carbonitrile results in increased expression of GRK5 mRNA CTD PMID:19162173 NCBI chr 1:282,265,371...282,467,842
Ensembl chr 1:282,265,370...282,462,605 		JBrowse link
G Grn granulin precursor increases expression ISO Pregnenolone Carbonitrile results in increased expression of GRN mRNA CTD PMID:28903501 NCBI chr10:90,377,103...90,383,207
Ensembl chr10:90,376,933...90,383,205 		JBrowse link
G Grpel2 GrpE-like 2, mitochondrial decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of GRPEL2 mRNA CTD PMID:28903501 NCBI chr18:57,037,995...57,050,234
Ensembl chr18:57,036,877...57,050,408 		JBrowse link
G Grwd1 glutamate-rich WD repeat containing 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of GRWD1 mRNA CTD PMID:28903501 NCBI chr 1:101,813,356...101,819,058
Ensembl chr 1:101,813,684...101,819,478 		JBrowse link
G Gsap gamma-secretase activating protein increases expression ISO Pregnenolone Carbonitrile results in increased expression of GSAP mRNA CTD PMID:28903501 NCBI chr 4:10,423,090...10,517,887
Ensembl chr 4:10,423,139...10,517,848 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression EXP
ISO		 Pregnenolone Carbonitrile results in increased expression of GSR mRNA CTD PMID:19162173, PMID:27413110 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions
increases expression		 ISO
EXP		 [Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to GSTA1 gene]] which results in increased expression of GSTA1 mRNA; [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of GSTA1 mRNA; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of GSTA1 mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of GSTA2 mRNA]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to GSTA1 gene]
Pregnenolone Carbonitrile results in increased expression of GSTA3 mRNA
Pregnenolone Carbonitrile results in increased expression of GSTA1 mRNA; Pregnenolone Carbonitrile results in increased expression of GSTA2 mRNA		 CTD PMID:19162173, PMID:20693526, PMID:22496397, PMID:22698814 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta4 glutathione S-transferase alpha 4 increases expression EXP Pregnenolone Carbonitrile results in increased expression of GSTA4 mRNA CTD PMID:19162173 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879 		JBrowse link
G Gsta6 glutathione S-transferase alpha 6 multiple interactions
increases expression		 ISO [Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to GSTA1 gene]] which results in increased expression of GSTA1 mRNA; [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of GSTA1 mRNA; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of GSTA1 mRNA]; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of GSTA2 mRNA]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to GSTA1 gene]
Pregnenolone Carbonitrile results in increased expression of GSTA1 mRNA; Pregnenolone Carbonitrile results in increased expression of GSTA2 mRNA		 CTD PMID:20693526, PMID:22496397, PMID:22698814 NCBI chr 9:27,475,273...27,533,939
Ensembl chr 9:27,475,273...27,511,176 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions
increases expression		 ISO
EXP		 [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of GSTM1 mRNA; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of GSTM1 mRNA]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to GSTM1 5' UTR] CTD PMID:18723825, PMID:19162173, PMID:20693526, PMID:22496397, PMID:27413110, PMID:28903501 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression
multiple interactions		 EXP
ISO		 Pregnenolone Carbonitrile results in increased expression of GSTM2 mRNA
[Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of GSTM2 mRNA; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of GSTM2 mRNA]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to GSTM2 gene]		 CTD PMID:18723825, PMID:19162173, PMID:20693526, PMID:22496397, PMID:27413110, PMID:28903501 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856 		JBrowse link
G Gstm3l glutathione S-transferase mu 3-like increases expression EXP Pregnenolone Carbonitrile results in increased expression of GSTM5 mRNA CTD PMID:19162173 NCBI chr 2:210,761,729...210,766,501
Ensembl chr 2:210,761,729...210,766,501 		JBrowse link
G Gstm4 glutathione S-transferase mu 4 increases expression ISO Pregnenolone Carbonitrile results in increased expression of GSTM4 mRNA CTD PMID:22496397 NCBI chr 2:210,834,013...210,839,242
Ensembl chr 2:210,833,884...210,839,295 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions
decreases expression
increases expression		 ISO [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of GSTM3 mRNA; NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of GSTM3 mRNA]
Pregnenolone Carbonitrile results in decreased expression of GSTM5 mRNA		 CTD PMID:18723825, PMID:22496397, PMID:27413110, PMID:28903501 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272 		JBrowse link
G Gtf2ird1 GTF2I repeat domain containing 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of GTF2IRD1 mRNA CTD PMID:19162173 NCBI chr12:25,264,052...25,370,947
Ensembl chr12:25,264,192...25,371,001 		JBrowse link
G Gyg1 glycogenin 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of GYG1 mRNA CTD PMID:19162173 NCBI chr 2:104,916,734...104,958,219
Ensembl chr 2:104,916,738...104,958,034 		JBrowse link
G Gys2 glycogen synthase 2 increases expression EXP Pregnenolone Carbonitrile results in increased expression of GYS2 mRNA CTD PMID:19162173 NCBI chr 4:176,638,632...176,679,805
Ensembl chr 4:176,638,629...176,679,815 		JBrowse link
G H1f0 H1 histone family, member 0 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of H1F0 mRNA CTD PMID:19162173 NCBI chr 7:120,260,776...120,262,636 JBrowse link
G H1f10 H1.10 linker histone increases expression ISO Pregnenolone Carbonitrile results in increased expression of H1F10 mRNA CTD PMID:22698814 NCBI chr 4:119,889,016...119,892,661
Ensembl chr 4:119,889,371...119,889,949 		JBrowse link
G H2az1 H2A.Z variant histone 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of H2AZ1 mRNA CTD PMID:19162173 NCBI chr 2:243,105,224...243,107,333
Ensembl chr 2:243,105,674...243,106,956 		JBrowse link
G H3f3b H3.3 histone B increases expression ISO Pregnenolone Carbonitrile results in increased expression of H3F3B mRNA CTD PMID:28903501 NCBI chr10:104,573,666...104,575,890
Ensembl chr10:104,573,664...104,575,890 		JBrowse link
G Hal histidine ammonia lyase decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of HAL mRNA CTD PMID:19162173 NCBI chr 7:34,326,087...34,356,413
Ensembl chr 7:34,326,087...34,356,413 		JBrowse link
G Hao2 hydroxyacid oxidase 2 decreases expression EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of HAO2 mRNA CTD PMID:19162173, PMID:28903501 NCBI chr 2:200,785,492...200,808,868
Ensembl chr 2:200,778,122...200,808,857 		JBrowse link
G Haspin histone H3 associated protein kinase increases expression ISO Pregnenolone Carbonitrile results in increased expression of HASPIN mRNA CTD PMID:22698814 NCBI chr10:59,695,403...59,698,398
Ensembl chr10:59,695,913...59,698,168 		JBrowse link
G Hdc histidine decarboxylase increases expression EXP Pregnenolone Carbonitrile results in increased expression of HDC mRNA CTD PMID:19162173 NCBI chr 3:119,057,524...119,075,599
Ensembl chr 3:119,057,517...119,075,619 		JBrowse link
G Heatr1 HEAT repeat containing 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of HEATR1 mRNA CTD PMID:28903501 NCBI chr17:66,446,135...66,488,303
Ensembl chr17:66,446,162...66,619,250 		JBrowse link
G Hectd2 HECT domain E3 ubiquitin protein ligase 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of HECTD2 mRNA CTD PMID:28903501 NCBI chr 1:255,186,729...255,254,307
Ensembl chr 1:255,185,629...255,254,307 		JBrowse link
G Herc2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of HERC2 mRNA CTD PMID:22698814 NCBI chr 1:114,453,033...114,653,787
Ensembl chr 1:114,453,054...114,653,793 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of HERPUD1 mRNA CTD PMID:28903501 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of HES1 mRNA CTD PMID:19162173 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248 		JBrowse link
G Hes6 hes family bHLH transcription factor 6 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of HES6 mRNA CTD PMID:28903501 NCBI chr 9:98,549,698...98,551,438
Ensembl chr 9:98,549,705...98,551,438 		JBrowse link
G Hfe homeostatic iron regulator increases expression EXP Pregnenolone Carbonitrile results in increased expression of HFE mRNA CTD PMID:19162173 NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985 		JBrowse link
G Hgf hepatocyte growth factor decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of HGF mRNA CTD PMID:19162173 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362 		JBrowse link
G Hgfac HGF activator decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of HGFAC mRNA CTD PMID:28903501 NCBI chr14:80,966,902...80,973,525
Ensembl chr14:80,966,903...80,973,456 		JBrowse link
G Hhex hematopoietically expressed homeobox decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of HHEX mRNA CTD PMID:28903501 NCBI chr 1:256,101,994...256,107,581
Ensembl chr 1:256,101,903...256,107,649 		JBrowse link
G Hif3a hypoxia inducible factor 3 subunit alpha increases expression ISO Pregnenolone Carbonitrile results in increased expression of HIF3A mRNA CTD PMID:28903501 NCBI chr 1:78,976,318...78,997,869
Ensembl chr 1:78,976,318...78,997,869 		JBrowse link
G Higd1a HIG1 hypoxia inducible domain family, member 1A decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of HIGD1A mRNA CTD PMID:19162173 NCBI chr 8:130,482,492...130,491,888
Ensembl chr 8:130,482,493...130,491,998 		JBrowse link
G Hist2h2be histone cluster 2 H2B family member E decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of H2BC21 mRNA CTD PMID:28903501 NCBI chr 2:198,360,837...198,363,399
Ensembl chr 2:198,360,998...198,361,378 		JBrowse link
G Hmg20b high mobility group 20 B increases expression EXP Pregnenolone Carbonitrile results in increased expression of HMG20B mRNA CTD PMID:19162173 NCBI chr 7:11,238,594...11,243,312
Ensembl chr 7:11,238,630...11,243,310 		JBrowse link
G Hmga2 high mobility group AT-hook 2 increases expression EXP Pregnenolone Carbonitrile results in increased expression of HMGA2 mRNA CTD PMID:19162173 NCBI chr 7:65,159,944...65,275,408
Ensembl chr 7:65,159,944...65,275,408 		JBrowse link
G Hmgb2 high mobility group box 2 increases expression EXP Pregnenolone Carbonitrile results in increased expression of HMGB2 mRNA CTD PMID:19162173 NCBI chr16:36,077,615...36,080,191
Ensembl chr16:36,077,617...36,080,191
Ensembl chr11:36,077,617...36,080,191 		JBrowse link
G Hmgcl 3-hydroxy-3-methylglutaryl-CoA lyase decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of HMGCL mRNA CTD PMID:19162173 NCBI chr 5:154,294,841...154,308,582
Ensembl chr 5:154,294,806...154,308,640 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases expression		 ISO [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in increased expression of HMGCR mRNA; NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of HMGCR mRNA] CTD PMID:20359477, PMID:22698814 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 multiple interactions
decreases expression		 ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of HMGCS2 mRNA]
Pregnenolone Carbonitrile results in decreased expression of HMGCS2 mRNA		 CTD PMID:20359477, PMID:28903501 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423 		JBrowse link
G Hmmr hyaluronan-mediated motility receptor increases expression EXP Pregnenolone Carbonitrile results in increased expression of HMMR mRNA CTD PMID:19162173 NCBI chr10:25,861,490...25,890,639
Ensembl chr10:25,861,490...25,890,639 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of HMOX1 mRNA CTD PMID:19162173 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hmox2 heme oxygenase 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of HMOX2 mRNA CTD PMID:28903501 NCBI chr10:10,990,034...11,035,493
Ensembl chr10:10,990,034...11,035,484 		JBrowse link
G Hnf1a HNF1 homeobox A decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of HNF1A mRNA CTD PMID:20888898 NCBI chr12:47,407,811...47,433,342
Ensembl chr12:47,407,811...47,433,342 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha increases expression
multiple interactions
decreases expression		 EXP
ISO		 Pregnenolone Carbonitrile results in increased expression of HNF4A mRNA
[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of HNF4A mRNA
Pregnenolone Carbonitrile results in decreased expression of HNF4A mRNA		 CTD PMID:19162173, PMID:20359477, PMID:20888898 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003 		JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C increases expression EXP Pregnenolone Carbonitrile results in increased expression of HNRNPC mRNA CTD PMID:19162173 NCBI chr15:28,486,605...28,517,353
Ensembl chr15:28,486,617...28,517,353 		JBrowse link
G Homer1 homer scaffold protein 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of HOMER1 mRNA CTD PMID:19162173 NCBI chr 2:22,909,550...23,012,303
Ensembl chr 2:22,909,569...23,009,678 		JBrowse link
G Hoxa2 homeobox A2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of HOXA2 mRNA CTD PMID:22698814 NCBI chr 4:82,130,441...82,134,846
Ensembl chr 4:82,131,329...82,133,605 		JBrowse link
G Hp haptoglobin increases expression ISO Pregnenolone Carbonitrile results in increased expression of HP mRNA CTD PMID:28903501 NCBI chr19:42,096,255...42,100,805
Ensembl chr19:42,097,995...42,100,804 		JBrowse link
G Hpx hemopexin increases expression ISO Pregnenolone Carbonitrile results in increased expression of HPX mRNA CTD PMID:28903501 NCBI chr 1:170,423,558...170,431,066
Ensembl chr 1:170,423,483...170,431,073 		JBrowse link
G Hrk harakiri, BCL2 interacting protein increases expression EXP Pregnenolone Carbonitrile results in increased expression of HRK mRNA CTD PMID:19162173 NCBI chr12:44,008,879...44,029,211 JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of HSD11B1 mRNA CTD PMID:19162173 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603 		JBrowse link
G Hsd17b11 hydroxysteroid (17-beta) dehydrogenase 11 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of HSD17B11 mRNA CTD PMID:27413110 NCBI chr14:7,054,724...7,104,567
Ensembl chr14:7,073,445...7,104,566 		JBrowse link
G Hsd17b13 hydroxysteroid (17-beta) dehydrogenase 13 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of HSD17B13 mRNA CTD PMID:28903501 NCBI chr14:7,113,544...7,128,218
Ensembl chr14:7,113,544...7,128,218 		JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of HSD17B2 mRNA CTD PMID:19162173 NCBI chr19:50,246,404...50,317,892
Ensembl chr19:50,246,402...50,317,891 		JBrowse link
G Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of HSD17B6 mRNA CTD PMID:19162173 NCBI chr 7:2,412,370...2,431,249
Ensembl chr 7:2,412,363...2,431,197
Ensembl chr13:2,412,363...2,431,197 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of HSD3B2 mRNA CTD PMID:28903501
G Hsd3b3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of HSD3B3 mRNA CTD PMID:28903501 NCBI chr 2:200,756,557...200,762,492
Ensembl chr 2:200,585,748...200,762,492 		JBrowse link
G Hsf4 heat shock transcription factor 4 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of HSF4 mRNA CTD PMID:28903501 NCBI chr19:37,225,800...37,232,048
Ensembl chr19:37,226,186...37,231,912 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of HSP90AA1 mRNA CTD PMID:19162173, PMID:21318169 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775 		JBrowse link
G Hspa14 heat shock protein family A (Hsp70) member 14 increases expression ISO Pregnenolone Carbonitrile results in increased expression of HSPA14 mRNA CTD PMID:28903501 NCBI chr17:78,735,630...78,756,412
Ensembl chr17:78,735,598...78,756,399 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B decreases expression
multiple interactions		 ISO Pregnenolone Carbonitrile results in decreased expression of HSPA1B mRNA
NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in decreased expression of HSPA1B mRNA]		 CTD PMID:22698814 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression EXP Pregnenolone Carbonitrile results in increased expression of HSPA8 mRNA CTD PMID:19162173, PMID:21318169 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179 		JBrowse link
G Hspb6 heat shock protein family B (small) member 6 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of HSPB6 mRNA CTD PMID:19162173 NCBI chr 1:89,008,117...89,010,256
Ensembl chr 1:89,008,117...89,010,256 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of HSPD1 mRNA CTD PMID:19162173 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956 		JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of HSPH1 mRNA CTD PMID:19162173, PMID:21318169 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902 		JBrowse link
G Htr4 5-hydroxytryptamine receptor 4 increases expression EXP Pregnenolone Carbonitrile results in increased expression of HTR4 mRNA CTD PMID:19162173 NCBI chr18:57,637,013...57,820,317
Ensembl chr18:57,654,290...57,819,698 		JBrowse link
G Htt huntingtin increases expression EXP Pregnenolone Carbonitrile results in increased expression of HTT mRNA CTD PMID:19162173 NCBI chr14:81,105,139...81,254,637
Ensembl chr14:81,105,139...81,254,637 		JBrowse link
G Hyou1 hypoxia up-regulated 1 increases expression EXP Pregnenolone Carbonitrile results in increased expression of HYOU1 mRNA CTD PMID:19162173 NCBI chr 8:48,699,796...48,711,912
Ensembl chr 8:48,699,769...48,711,910 		JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ID1 mRNA CTD PMID:19162173 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718 		JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of ID2 mRNA CTD PMID:19162173 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of IDH2 mRNA CTD PMID:28903501 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705 		JBrowse link
G Ier3 immediate early response 3 decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of IER3 mRNA CTD PMID:22698814 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769 		JBrowse link
G Ifitm2 interferon induced transmembrane protein 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of IFITM2 mRNA CTD PMID:28903501 NCBI chr 1:213,750,219...213,751,399
Ensembl chr 1:213,750,192...213,751,405 		JBrowse link
G Ifitm5 interferon induced transmembrane protein 5 increases expression ISO Pregnenolone Carbonitrile results in increased expression of IFITM5 mRNA CTD PMID:28903501 NCBI chr 1:213,743,331...213,749,879
Ensembl chr 1:213,744,796...213,745,748 		JBrowse link
G Ifnar2 interferon alpha and beta receptor subunit 2 increases expression ISO Pregnenolone Carbonitrile results in increased expression of IFNAR2 mRNA CTD PMID:28903501 NCBI chr11:31,527,790...31,559,834
Ensembl chr11:31,539,016...31,558,851 		JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression EXP Pregnenolone Carbonitrile results in decreased expression of IGF1 mRNA CTD PMID:19162173 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609 		JBrowse link
G Igfals insulin-like growth factor binding protein, acid labile subunit decreases expression EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of IGFALS mRNA CTD PMID:19162173, PMID:28903501 NCBI chr10:14,240,308...14,243,554
Ensembl chr10:14,240,219...14,243,597 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 decreases expression
increases expression		 EXP
ISO		 Pregnenolone Carbonitrile results in decreased expression of IGFBP1 mRNA
Pregnenolone Carbonitrile results in increased expression of IGFBP1 mRNA		 CTD PMID:19162173, PMID:22698814, PMID:27413110, PMID:28903501 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785 		JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression
decreases expression		 EXP
ISO		 Pregnenolone Carbonitrile results in increased expression of IGFBP2 mRNA
Pregnenolone Carbonitrile results in decreased expression of IGFBP2 mRNA		 CTD PMID:19162173, PMID:21318169, PMID:27413110, PMID:28903501 NCBI chr 9:80,118,029...80,144,804
Ensembl chr 9:80,118,029...80,144,789 		JBrowse link
G IgG-2a gamma-2a immunoglobulin heavy chain increases expression EXP Pregnenolone Carbonitrile results in increased expression of IGG-2A mRNA CTD PMID:19162173
G Ihh Indian hedgehog signaling molecule decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of IHH mRNA CTD PMID:28903501 NCBI chr 9:82,208,223...82,214,440
Ensembl chr 9:82,208,223...82,214,440 		JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon decreases expression ISO Pregnenolone Carbonitrile results in decreased expression of IKBKE mRNA CTD PMID:28903501 NCBI chr13:48,031,325...48,056,394
Ensembl chr13:48,031,410...48,056,394 		JBrowse link
G Il13 interleukin 13 increases expression EXP Pregnenolone Carbonitrile results in increased expression of IL13 mRNA CTD PMID:19162173 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466 		JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 increases expression ISO Pregnenolone Carbonitrile results in increased expression of IL13RA1 mRNA CTD PMID:27413110, PMID:28903501 NCBI chr  X:122,724,081...122,783,801
Ensembl chr  X:122,724,129...122,781,479 		JBrowse link
G