Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sphinganine
go back to main search page
Accession:CHEBI:16566 term browser browse the term
Definition:A 2-aminooctadecane-1,3-diol having (2S,3R)-configuration.
Synonyms:related_synonym: (2S,3R)-2-amino-1,3-octadecanediol;   (2S,3R)-2-aminooctadecane-1,3-diol;   (R-(R*,S*))-2-aminooctadecane-1,3-diol;   2-Amino-1,3-dihydroxyoctadecane;   C18-dihydrosphingosine;   C18-sphinganine;   D-erythro-1,3-dihydroxy-2-aminooctadecane;   D-erythro-2-amino-1,3-octadecanediol;   D-erythro-C18-dihydrosphingosine;   Dihydrosphingosine;   Formula=C18H39NO2;   InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18+/m0/s1;   InChIKey=OTKJDMGTUTTYMP-ZWKOTPCHSA-N;   SMILES=CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)CO;   Safingol;   d18:0;   octadecasphinganine
 alt_id: CHEBI:15099;   CHEBI:26736;   CHEBI:26737;   CHEBI:549953;   CHEBI:9221
 xref: Beilstein:1724230;   CAS:764-22-7;   HMDB:HMDB0000269;   KEGG:C00836;   KNApSAcK:C00007540;   LIPID_MAPS_instance:LMSP01020001;   MetaCyc:CPD-13612;   PMID:17085324;   PMID:1817037;   PMID:7654391;   PMID:7819132;   Reaxys:1724230
 cyclic_relationship: is_conjugate_base_of CHEBI:57817


show annotations for term's descendants           Sort by:
 
1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO KRN 7000 results in increased expression of CXCL10 protein CTD PMID:15867097 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Il12b interleukin 12B increases expression ISO KRN 7000 results in increased expression of IL12B protein CTD PMID:15867097 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
N-acylsphinganine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases cleavage ISO dihydroceramide metabolite results in increased cleavage of CASP3 protein CTD PMID:17586710 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 increases cleavage ISO dihydroceramide metabolite results in increased cleavage of CASP6 protein CTD PMID:17586710 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp9 caspase 9 increases cleavage ISO dihydroceramide metabolite results in increased cleavage of CASP9 protein CTD PMID:17586710 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
phytosphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization
multiple interactions
ISO phytosphingosine affects the localization of AIFM1 protein
3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [phytosphingosine affects the localization of AIFM1 protein]
CTD PMID:15486061 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects localization
ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein; Acetylcysteine inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]; SB 203580 inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]
phytosphingosine affects the localization of BAX protein
CTD PMID:15486061, PMID:17237268 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Casp3 caspase 3 multiple interactions ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein; SB 203580 inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein] CTD PMID:17237268 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein; SB 203580 inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein] CTD PMID:17237268 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [arsenic trioxide co-treated with phytosphingosine] results in decreased phosphorylation of MAPK1 protein CTD PMID:17237268 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein; Acetylcysteine inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein] CTD PMID:17237268 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [arsenic trioxide co-treated with phytosphingosine] results in decreased phosphorylation of MAPK3 protein CTD PMID:17237268 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases activity
ISO 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein]; [Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein; [Arsenic Trioxide co-treated with phytosphingosine] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein]
phytosphingosine results in increased activity of PARP1 protein
CTD PMID:15486061, PMID:17237268 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
sphinganine 1-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO dihydrosphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; dihydrosphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein]; dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein]
dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA; dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein
CTD PMID:18612546 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Spns2 sphingolipid transporter 2 decreases abundance ISO SPNS2 protein results in decreased abundance of dihydrosphingosine 1-phosphate CTD PMID:29772789 NCBI chr10:59,010,428...59,049,482
Ensembl chr10:59,010,428...59,049,482
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        inhibitor 18221
          enzyme inhibitor 18148
            EC 2.* (transferase) inhibitor 13808
              EC 2.7.* (P-containing group transferase) inhibitor 13493
                EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8161
                  EC 2.7.11.13 (protein kinase C) inhibitor 3426
                    sphinganine 13
                      1-deoxymethylsphinganine 0
                      1-deoxysphinganine + 0
                      3-dehydrosphinganine + 0
                      D-glucosylsphinganine 0
                      N-(2-hydroxytetracosanoyl)sphinganine + 0
                      N-acylsphinganine + 3
                      N-acylsphinganine-1-phosphocholine + 0
                      N-hexacosanoylsphinganine + 0
                      beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphinganine + 0
                      hexosyl-(1<->1')-N-acylsphinganine + 0
                      inositol phosphomannosylinositol-1-phosphodihydroceramide + 0
                      phytosphingosine + 10
                      sphinganine 1-phosphate 2
                      sphinganine-1-phosphocholine 0
                      sphinganine-based sphingolipid + 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            inorganic hydride 17409
                              pnictogen hydride 17381
                                nitrogen hydride 17223
                                  azane 16940
                                    ammonia 16939
                                      organic amino compound 16938
                                        amino alcohol 882
                                          aminodiol 153
                                            2-aminooctadecane-1,3-diol 13
                                              sphinganine 13
                                                1-deoxymethylsphinganine 0
                                                1-deoxysphinganine + 0
                                                3-dehydrosphinganine + 0
                                                D-glucosylsphinganine 0
                                                N-(2-hydroxytetracosanoyl)sphinganine + 0
                                                N-acylsphinganine + 3
                                                N-acylsphinganine-1-phosphocholine + 0
                                                N-hexacosanoylsphinganine + 0
                                                beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphinganine + 0
                                                hexosyl-(1<->1')-N-acylsphinganine + 0
                                                inositol phosphomannosylinositol-1-phosphodihydroceramide + 0
                                                phytosphingosine + 10
                                                sphinganine 1-phosphate 2
                                                sphinganine-1-phosphocholine 0
                                                sphinganine-based sphingolipid + 3
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.