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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tetrahydropalmatine
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Accession:CHEBI:16563 term browser browse the term
Definition:A berberine alkaloid obtained by formal addition of two molecules of hydrogen to the pyridine ring of palmatine.
Synonyms:exact_synonym: (13aS)-2,3,9,10-tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline
 related_synonym: (S)-Tetrahydropalmatine;   2,3,9,10-tetramethoxy-13aalpha-berbine;   Formula=C21H25NO4;   InChI=1S/C21H25NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,10-11,17H,7-9,12H2,1-4H3/t17-/m0/s1;   InChIKey=AEQDJSLRWYMAQI-KRWDZBQOSA-N;   L-tetrahydropalmatine;   SMILES=[H][C@@]12Cc3ccc(OC)c(OC)c3CN1CCc1cc(OC)c(OC)cc21
 alt_id: CHEBI:15223;   CHEBI:26917;   CHEBI:9486
 xref: CAS:483-14-7;   KEGG:C02890;   KNApSAcK:C00025252
 xref_mesh: MESH:C014215
 xref: MetaCyc:TETRAHYDROPALMATINE;   PMID:10680579;   PMID:11488467;   PMID:12709895;   PMID:17260290;   PMID:19544352;   PMID:19927376;   PMID:20083181;   PMID:20109541;   PMID:20234973;   PMID:20349723;   PMID:20828314;   PMID:20884991;   PMID:21196089;   PMID:21319371;   PMID:21493954;   PMID:21633914;   PMID:21678521;   PMID:21733652;   Reaxys:96288;   Wikipedia:Tetrahydropalmatine


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tetrahydropalmatine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCF1 ATP binding cassette subfamily F member 1 decreases expression EXP tetrahydropalmatine results in decreased expression of ABCF1 protein CTD PMID:20109541 NCBI chr 6:30,571,442...30,591,522
Ensembl chr 6:30,571,393...30,597,179 		JBrowse link
G ACBD3 acyl-CoA binding domain containing 3 increases expression EXP tetrahydropalmatine results in increased expression of ACBD3 protein CTD PMID:20109541 NCBI chr 1:226,144,679...226,186,741
Ensembl chr 1:226,144,679...226,186,741 		JBrowse link
G ACOT9 acyl-CoA thioesterase 9 decreases expression EXP tetrahydropalmatine results in decreased expression of ACOT9 protein CTD PMID:20109541 NCBI chr  X:23,701,055...23,743,276
Ensembl chr  X:23,701,055...23,766,475 		JBrowse link
G ALDH5A1 aldehyde dehydrogenase 5 family member A1 increases expression EXP tetrahydropalmatine results in increased expression of ALDH5A1 protein CTD PMID:20109541 NCBI chr 6:24,494,969...24,537,207
Ensembl chr 6:24,494,867...24,537,207 		JBrowse link
G ANP32AP1 acidic nuclear phosphoprotein 32 family member A pseudogene 1 decreases expression EXP tetrahydropalmatine results in decreased expression of ANP32AP1 protein CTD PMID:20109541 NCBI chr15:35,237,150...35,238,197
Ensembl chr15:35,237,326...35,238,062 		JBrowse link
G AP2A1 adaptor related protein complex 2 subunit alpha 1 increases expression EXP tetrahydropalmatine results in increased expression of AP2A1 protein CTD PMID:20109541 NCBI chr19:49,767,001...49,807,114
Ensembl chr19:49,767,001...49,807,114 		JBrowse link
G AR androgen receptor multiple interactions ISO tetrahydropalmatine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of AR mRNA] CTD PMID:37606869 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G ARHGAP1 Rho GTPase activating protein 1 decreases expression EXP tetrahydropalmatine results in decreased expression of ARHGAP1 protein CTD PMID:20109541 NCBI chr11:46,677,080...46,700,619
Ensembl chr11:46,677,080...46,700,619 		JBrowse link
G ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 decreases expression EXP tetrahydropalmatine results in decreased expression of ARIH1 protein CTD PMID:20109541 NCBI chr15:72,474,330...72,602,987
Ensembl chr15:72,474,330...72,602,987 		JBrowse link
G ARPC3 actin related protein 2/3 complex subunit 3 decreases expression EXP tetrahydropalmatine results in decreased expression of ARPC3 protein CTD PMID:20109541 NCBI chr12:110,434,823...110,450,337
Ensembl chr12:110,434,823...110,450,422 		JBrowse link
G ARPP19 cAMP regulated phosphoprotein 19 decreases expression EXP tetrahydropalmatine results in decreased expression of ARPP19 protein CTD PMID:20109541 NCBI chr15:52,547,045...52,569,446
Ensembl chr15:52,547,045...52,569,883 		JBrowse link
G ATAD3A ATPase family AAA domain containing 3A increases expression EXP tetrahydropalmatine results in increased expression of ATAD3A protein CTD PMID:20109541 NCBI chr 1:1,512,162...1,534,685
Ensembl chr 1:1,512,162...1,534,685 		JBrowse link
G ATP2B1 ATPase plasma membrane Ca2+ transporting 1 decreases expression EXP tetrahydropalmatine results in decreased expression of ATP2B1 protein CTD PMID:20109541 NCBI chr12:89,588,049...89,709,366
Ensembl chr12:89,588,049...89,709,366 		JBrowse link
G BAD BCL2 associated agonist of cell death increases expression EXP tetrahydropalmatine results in increased expression of BAD protein CTD PMID:20109541 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression EXP tetrahydropalmatine results in increased expression of BAX protein CTD PMID:20109541 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCAR1 BCAR1 scaffold protein, Cas family member decreases expression EXP tetrahydropalmatine results in decreased expression of BCAR1 protein CTD PMID:20109541 NCBI chr16:75,228,181...75,268,007
Ensembl chr16:75,228,181...75,268,053 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP tetrahydropalmatine results in decreased expression of BCL2 protein CTD PMID:20109541 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BZW1 basic leucine zipper and W2 domains 1 decreases expression EXP tetrahydropalmatine results in decreased expression of BZW1 protein CTD PMID:20109541 NCBI chr 2:200,811,589...200,827,338
Ensembl chr 2:200,810,594...200,827,338 		JBrowse link
G CALD1 caldesmon 1 decreases expression
increases expression		 EXP tetrahydropalmatine results in decreased expression of CALD1 protein
tetrahydropalmatine results in increased expression of CALD1 protein		 CTD PMID:20109541 NCBI chr 7:134,745,467...134,970,729
Ensembl chr 7:134,744,252...134,970,729 		JBrowse link
G CALU calumenin decreases expression EXP tetrahydropalmatine results in decreased expression of CALU protein CTD PMID:20109541 NCBI chr 7:128,739,359...128,773,400
Ensembl chr 7:128,739,292...128,773,400 		JBrowse link
G CASP3 caspase 3 increases cleavage EXP tetrahydropalmatine results in increased cleavage of CASP3 protein CTD PMID:20109541 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CAVIN3 caveolae associated protein 3 decreases expression EXP tetrahydropalmatine results in decreased expression of CAVIN3 protein CTD PMID:20109541 NCBI chr11:6,318,946...6,320,501
Ensembl chr11:6,318,946...6,320,532 		JBrowse link
G CC2D1B coiled-coil and C2 domain containing 1B decreases expression EXP tetrahydropalmatine results in decreased expression of CC2D1B protein CTD PMID:20109541 NCBI chr 1:52,350,597...52,366,205
Ensembl chr 1:52,345,723...52,366,205 		JBrowse link
G CKAP5 cytoskeleton associated protein 5 decreases expression EXP tetrahydropalmatine results in decreased expression of CKAP5 protein CTD PMID:20109541 NCBI chr11:46,743,048...46,846,280
Ensembl chr11:46,743,048...46,846,308 		JBrowse link
G CKB creatine kinase B decreases secretion ISO tetrahydropalmatine results in decreased secretion of CKB protein CTD PMID:37606869 NCBI chr14:103,519,667...103,522,830
Ensembl chr14:103,519,667...103,522,833 		JBrowse link
G CLIP1 CAP-Gly domain containing linker protein 1 decreases expression EXP tetrahydropalmatine results in decreased expression of CLIP1 protein CTD PMID:20109541 NCBI chr12:122,271,469...122,422,956
Ensembl chr12:122,271,432...122,422,669 		JBrowse link
G COA6 cytochrome c oxidase assembly factor 6 decreases expression EXP tetrahydropalmatine results in decreased expression of COA6 protein CTD PMID:20109541 NCBI chr 1:234,373,456...234,385,080
Ensembl chr 1:234,373,456...234,385,080 		JBrowse link
G COASY Coenzyme A synthase decreases expression EXP tetrahydropalmatine results in decreased expression of COASY protein CTD PMID:20109541 NCBI chr17:42,562,148...42,566,277
Ensembl chr17:42,561,467...42,566,277 		JBrowse link
G COPS2 COP9 signalosome subunit 2 decreases expression EXP tetrahydropalmatine results in decreased expression of COPS2 protein CTD PMID:20109541 NCBI chr15:49,122,727...49,155,599
Ensembl chr15:49,106,068...49,155,661 		JBrowse link
G COPS3 COP9 signalosome subunit 3 decreases expression EXP tetrahydropalmatine results in decreased expression of COPS3 protein CTD PMID:20109541 NCBI chr17:17,246,616...17,281,246
Ensembl chr17:17,246,616...17,281,273 		JBrowse link
G COX6C cytochrome c oxidase subunit 6C increases expression EXP tetrahydropalmatine results in increased expression of COX6C protein CTD PMID:20109541 NCBI chr 8:99,877,865...99,893,707
Ensembl chr 8:99,873,200...99,893,707 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A decreases expression EXP tetrahydropalmatine results in decreased expression of CPT1A protein CTD PMID:20109541 NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410 		JBrowse link
G CRIP2 cysteine rich protein 2 decreases expression EXP tetrahydropalmatine results in decreased expression of CRIP2 protein CTD PMID:20109541 NCBI chr14:105,472,945...105,480,170
Ensembl chr14:105,472,962...105,480,162 		JBrowse link
G CRYZ crystallin zeta decreases expression EXP tetrahydropalmatine results in decreased expression of CRYZ protein CTD PMID:20109541 NCBI chr 1:74,705,486...74,733,050
Ensembl chr 1:74,705,482...74,733,408 		JBrowse link
G CSDE1 cold shock domain containing E1 decreases expression EXP tetrahydropalmatine results in decreased expression of CSDE1 protein CTD PMID:20109541 NCBI chr 1:114,716,916...114,757,984
Ensembl chr 1:114,716,913...114,758,676 		JBrowse link
G CSTB cystatin B increases expression EXP tetrahydropalmatine results in increased expression of CSTB protein CTD PMID:20109541 NCBI chr21:43,773,950...43,776,308
Ensembl chr21:43,772,511...43,776,330 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases expression ISO tetrahydropalmatine results in decreased expression of CYP1A2 mRNA; tetrahydropalmatine results in decreased expression of CYP1A2 protein CTD PMID:28257954 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G DCAF7 DDB1 and CUL4 associated factor 7 decreases expression EXP tetrahydropalmatine results in decreased expression of DCAF7 protein CTD PMID:20109541 NCBI chr17:63,550,477...63,594,266
Ensembl chr17:63,550,222...63,594,286 		JBrowse link
G DCTN2 dynactin subunit 2 decreases expression EXP tetrahydropalmatine results in decreased expression of DCTN2 protein CTD PMID:20109541 NCBI chr12:57,530,051...57,547,192
Ensembl chr12:57,529,633...57,547,224 		JBrowse link
G DDX19B DEAD-box helicase 19B decreases expression EXP tetrahydropalmatine results in decreased expression of DDX19B protein CTD PMID:20109541 NCBI chr16:70,289,767...70,335,305
Ensembl chr16:70,289,663...70,335,305 		JBrowse link
G DDX50 DExD-box helicase 50 decreases expression EXP tetrahydropalmatine results in decreased expression of DDX50 protein CTD PMID:20109541 NCBI chr10:68,901,315...68,946,847
Ensembl chr10:68,901,286...68,946,847 		JBrowse link
G DECR2 2,4-dienoyl-CoA reductase 2 increases expression EXP tetrahydropalmatine results in increased expression of DECR2 protein CTD PMID:20109541 NCBI chr16:401,885...412,482
Ensembl chr16:401,858...412,487 		JBrowse link
G DHX8 DEAH-box helicase 8 increases expression EXP tetrahydropalmatine results in increased expression of DHX8 protein CTD PMID:20109541 NCBI chr17:43,483,975...43,544,799
Ensembl chr17:43,483,865...43,610,338 		JBrowse link
G DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 decreases expression EXP tetrahydropalmatine results in decreased expression of DNAJB11 protein CTD PMID:20109541 NCBI chr 3:186,570,720...186,585,793
Ensembl chr 3:186,567,403...186,585,800 		JBrowse link
G DPP3 dipeptidyl peptidase 3 decreases expression EXP tetrahydropalmatine results in decreased expression of DPP3 protein CTD PMID:20109541 NCBI chr11:66,480,434...66,509,657
Ensembl chr11:66,480,013...66,509,657 		JBrowse link
G DRD1 dopamine receptor D1 multiple interactions EXP tetrahydropalmatine binds to and results in decreased activity of DRD1 protein CTD PMID:17361394 NCBI chr 5:175,440,036...175,444,182
Ensembl chr 5:175,440,036...175,444,182 		JBrowse link
G DRD2 dopamine receptor D2 multiple interactions EXP tetrahydropalmatine binds to and results in decreased activity of DRD2 protein CTD PMID:17361394 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691 		JBrowse link
G DRD3 dopamine receptor D3 affects binding ISO tetrahydropalmatine binds to DRD3 protein CTD PMID:17361394 NCBI chr 3:114,127,580...114,199,407
Ensembl chr 3:114,127,580...114,199,407 		JBrowse link
G DYNC1I2 dynein cytoplasmic 1 intermediate chain 2 decreases expression EXP tetrahydropalmatine results in decreased expression of DYNC1I2 protein CTD PMID:20109541 NCBI chr 2:171,687,469...171,750,158
Ensembl chr 2:171,687,409...171,750,158 		JBrowse link
G DYNC1LI2 dynein cytoplasmic 1 light intermediate chain 2 decreases expression EXP tetrahydropalmatine results in decreased expression of DYNC1LI2 protein CTD PMID:20109541 NCBI chr16:66,720,893...66,751,609
Ensembl chr16:66,720,893...66,751,609 		JBrowse link
G EEF1A1 eukaryotic translation elongation factor 1 alpha 1 increases expression EXP tetrahydropalmatine results in increased expression of EEF1A1 protein CTD PMID:20109541 NCBI chr 6:73,515,750...73,521,032
Ensembl chr 6:73,489,308...73,525,587 		JBrowse link
G EEF1A2 eukaryotic translation elongation factor 1 alpha 2 decreases expression EXP tetrahydropalmatine results in decreased expression of EEF1A2 protein CTD PMID:20109541 NCBI chr20:63,488,014...63,499,083
Ensembl chr20:63,488,013...63,499,239 		JBrowse link
G EIF1 eukaryotic translation initiation factor 1 decreases expression EXP tetrahydropalmatine results in decreased expression of EIF1 protein CTD PMID:20109541 NCBI chr17:41,688,885...41,692,668
Ensembl chr17:41,688,885...41,692,668 		JBrowse link
G EIF4A2 eukaryotic translation initiation factor 4A2 decreases expression EXP tetrahydropalmatine results in decreased expression of EIF4A2 protein CTD PMID:20109541 NCBI chr 3:186,783,577...186,789,897
Ensembl chr 3:186,783,205...186,789,897 		JBrowse link
G ESR1 estrogen receptor 1 decreases expression
multiple interactions		 ISO tetrahydropalmatine results in decreased expression of ESR1 mRNA
tetrahydropalmatine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of ESR1 mRNA]		 CTD PMID:37606869 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G EXOC8 exocyst complex component 8 decreases expression EXP tetrahydropalmatine results in decreased expression of EXOC8 protein CTD PMID:20109541 NCBI chr 1:231,332,753...231,337,852
Ensembl chr 1:231,332,753...231,337,852 		JBrowse link
G FAF2 Fas associated factor family member 2 decreases expression EXP tetrahydropalmatine results in decreased expression of FAF2 protein CTD PMID:20109541 NCBI chr 5:176,448,385...176,510,074
Ensembl chr 5:176,447,628...176,510,074 		JBrowse link
G FAH fumarylacetoacetate hydrolase decreases expression EXP tetrahydropalmatine results in decreased expression of FAH protein CTD PMID:20109541 NCBI chr15:80,152,789...80,186,949
Ensembl chr15:80,152,490...80,186,946 		JBrowse link
G FAM136A family with sequence similarity 136 member A decreases expression EXP tetrahydropalmatine results in decreased expression of FAM136A protein CTD PMID:20109541 NCBI chr 2:70,295,976...70,302,067
Ensembl chr 2:70,295,976...70,302,067 		JBrowse link
G FKBP8 FKBP prolyl isomerase 8 decreases expression EXP tetrahydropalmatine results in decreased expression of FKBP8 protein CTD PMID:20109541 NCBI chr19:18,531,763...18,543,573
Ensembl chr19:18,531,751...18,544,077 		JBrowse link
G FLYWCH2 FLYWCH family member 2 decreases expression EXP tetrahydropalmatine results in decreased expression of FLYWCH2 protein CTD PMID:20109541 NCBI chr16:2,883,195...2,899,382
Ensembl chr16:2,883,213...2,899,382 		JBrowse link
G FMR1 fragile X messenger ribonucleoprotein 1 decreases expression EXP tetrahydropalmatine results in decreased expression of FMR1 protein CTD PMID:20109541 NCBI chr  X:147,911,919...147,951,125
Ensembl chr  X:147,911,919...147,951,125 		JBrowse link
G GALK1 galactokinase 1 decreases expression EXP tetrahydropalmatine results in decreased expression of GALK1 protein CTD PMID:20109541 NCBI chr17:75,751,469...75,765,192
Ensembl chr17:75,751,594...75,765,236 		JBrowse link
G GANAB glucosidase II alpha subunit decreases expression EXP tetrahydropalmatine results in decreased expression of GANAB protein CTD PMID:20109541 NCBI chr11:62,624,829...62,646,613
Ensembl chr11:62,624,826...62,646,726 		JBrowse link
G GGH gamma-glutamyl hydrolase increases expression EXP tetrahydropalmatine results in increased expression of GGH protein CTD PMID:20109541 NCBI chr 8:63,015,079...63,038,806
Ensembl chr 8:63,014,881...63,039,407 		JBrowse link
G GLRX glutaredoxin decreases expression EXP tetrahydropalmatine results in decreased expression of GLRX protein CTD PMID:20109541 NCBI chr 5:95,813,849...95,822,726
Ensembl chr 5:95,751,319...95,822,726 		JBrowse link
G GMPPB GDP-mannose pyrophosphorylase B increases expression EXP tetrahydropalmatine results in increased expression of GMPPB protein CTD PMID:20109541 NCBI chr 3:49,719,916...49,723,951
Ensembl chr 3:49,716,844...49,723,973 		JBrowse link
G GPX4 glutathione peroxidase 4 decreases expression EXP tetrahydropalmatine results in decreased expression of GPX4 protein CTD PMID:20109541 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,982...1,106,791 		JBrowse link
G GRIA1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions ISO L-THP inhibits the reaction [Morphine increases expression of Gria1 protein in the striatum] RGD PMID:32717192 RGD:405100728 NCBI chr 5:153,489,615...153,813,869
Ensembl chr 5:153,489,615...153,813,869 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta decreases expression ISO tetrahydropalmatine results in decreased expression of GSK3B mRNA CTD PMID:37606869 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994 		JBrowse link
G GSN gelsolin decreases expression EXP tetrahydropalmatine results in decreased expression of GSN protein CTD PMID:20109541 NCBI chr 9:121,201,483...121,332,842
Ensembl chr 9:121,207,794...121,332,843 		JBrowse link
G GTPBP4 GTP binding protein 4 decreases expression EXP tetrahydropalmatine results in decreased expression of GTPBP4 protein CTD PMID:20109541 NCBI chr10:988,434...1,019,932
Ensembl chr10:988,434...1,019,932 		JBrowse link
G HIBCH 3-hydroxyisobutyryl-CoA hydrolase increases expression EXP tetrahydropalmatine results in increased expression of HIBCH protein CTD PMID:20109541 NCBI chr 2:190,189,735...190,319,826
Ensembl chr 2:190,189,735...190,344,193 		JBrowse link
G HINT2 histidine triad nucleotide binding protein 2 decreases expression EXP tetrahydropalmatine results in decreased expression of HINT2 protein CTD PMID:20109541 NCBI chr 9:35,812,960...35,815,479
Ensembl chr 9:35,812,960...35,815,354 		JBrowse link
G HK1 hexokinase 1 decreases expression
increases expression		 EXP tetrahydropalmatine results in decreased expression of HK1 protein
tetrahydropalmatine results in increased expression of HK1 protein		 CTD PMID:20109541 NCBI chr10:69,270,000...69,401,882
Ensembl chr10:69,269,984...69,401,884 		JBrowse link
G HMGA1 high mobility group AT-hook 1 decreases expression EXP tetrahydropalmatine results in decreased expression of HMGA1 protein CTD PMID:20109541 NCBI chr 6:34,236,873...34,246,231
Ensembl chr 6:34,236,873...34,246,231 		JBrowse link
G HMOX1 heme oxygenase 1 decreases expression EXP tetrahydropalmatine results in decreased expression of HMOX1 protein CTD PMID:20109541 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HNRNPCL1 heterogeneous nuclear ribonucleoprotein C like 1 decreases expression EXP tetrahydropalmatine results in decreased expression of HNRNPCL1 protein CTD PMID:20109541 NCBI chr 1:12,847,377...12,848,720
Ensembl chr 1:12,847,377...12,848,720 		JBrowse link
G HNRNPUL2 heterogeneous nuclear ribonucleoprotein U like 2 increases expression EXP tetrahydropalmatine results in increased expression of HNRNPUL2 protein CTD PMID:20109541 NCBI chr11:62,712,630...62,727,457
Ensembl chr11:62,712,630...62,727,457 		JBrowse link
G IGF2BP3 insulin like growth factor 2 mRNA binding protein 3 decreases expression EXP tetrahydropalmatine results in decreased expression of IGF2BP3 protein CTD PMID:20109541 NCBI chr 7:23,310,209...23,470,491
Ensembl chr 7:23,310,209...23,470,491 		JBrowse link
G IPO9 importin 9 decreases expression EXP tetrahydropalmatine results in decreased expression of IPO9 protein CTD PMID:20109541 NCBI chr 1:201,829,157...201,884,291
Ensembl chr 1:201,829,149...201,884,291 		JBrowse link
G IQGAP3 IQ motif containing GTPase activating protein 3 decreases expression EXP tetrahydropalmatine results in decreased expression of IQGAP3 protein CTD PMID:20109541 NCBI chr 1:156,525,405...156,572,565
Ensembl chr 1:156,525,405...156,572,604 		JBrowse link
G JPT2 Jupiter microtubule associated homolog 2 decreases expression EXP tetrahydropalmatine results in decreased expression of JPT2 protein CTD PMID:20109541 NCBI chr16:1,678,279...1,702,086
Ensembl chr16:1,678,256...1,702,280 		JBrowse link
G LETM1 leucine zipper and EF-hand containing transmembrane protein 1 decreases expression EXP tetrahydropalmatine results in decreased expression of LETM1 protein CTD PMID:20109541 NCBI chr 4:1,811,479...1,856,156
Ensembl chr 4:1,811,479...1,856,156 		JBrowse link
G LTA4H leukotriene A4 hydrolase decreases expression EXP tetrahydropalmatine results in decreased expression of LTA4H protein CTD PMID:20109541 NCBI chr12:96,000,753...96,043,520
Ensembl chr12:96,000,753...96,043,520 		JBrowse link
G MAK16 MAK16 homolog decreases expression EXP tetrahydropalmatine results in decreased expression of MAK16 protein CTD PMID:20109541 NCBI chr 8:33,485,182...33,501,262
Ensembl chr 8:33,485,182...33,501,262 		JBrowse link
G MAN1B1 mannosidase alpha class 1B member 1 increases expression EXP tetrahydropalmatine results in increased expression of MAN1B1 protein CTD PMID:20109541 NCBI chr 9:137,086,985...137,109,183
Ensembl chr 9:137,086,857...137,109,189 		JBrowse link
G MAP1B microtubule associated protein 1B increases expression EXP tetrahydropalmatine results in increased expression of MAP1B protein CTD PMID:20109541 NCBI chr 5:72,107,475...72,209,565
Ensembl chr 5:72,107,234...72,209,565 		JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 decreases expression EXP tetrahydropalmatine results in decreased expression of MAP2K2 protein CTD PMID:20109541 NCBI chr19:4,090,321...4,124,122
Ensembl chr19:4,090,321...4,124,122 		JBrowse link
G METAP2 methionyl aminopeptidase 2 decreases expression EXP tetrahydropalmatine results in decreased expression of METAP2 protein CTD PMID:20109541 NCBI chr12:95,474,152...95,515,839
Ensembl chr12:95,473,520...95,515,839 		JBrowse link
G MMP9 matrix metallopeptidase 9 decreases expression ISO tetrahydropalmatine results in decreased expression of MMP9 mRNA CTD PMID:37606869 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MTOR mechanistic target of rapamycin kinase decreases expression EXP tetrahydropalmatine results in decreased expression of MTOR protein CTD PMID:20109541 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556 		JBrowse link
G NCAPH non-SMC condensin I complex subunit H increases expression EXP tetrahydropalmatine results in increased expression of NCAPH protein CTD PMID:20109541 NCBI chr 2:96,335,766...96,377,091
Ensembl chr 2:96,335,766...96,377,091 		JBrowse link
G NCEH1 neutral cholesterol ester hydrolase 1 decreases expression EXP tetrahydropalmatine results in decreased expression of NCEH1 protein CTD PMID:20109541 NCBI chr 3:172,630,249...172,711,067
Ensembl chr 3:172,630,249...172,711,218 		JBrowse link
G NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 decreases expression EXP tetrahydropalmatine results in decreased expression of NDUFB5 protein CTD PMID:20109541 NCBI chr 3:179,604,794...179,627,647
Ensembl chr 3:179,604,690...179,627,647 		JBrowse link
G NELFE negative elongation factor complex member E decreases expression EXP tetrahydropalmatine results in decreased expression of NELFE protein CTD PMID:20109541 NCBI chr 6:31,952,087...31,958,971
Ensembl chr 6:31,952,087...31,959,038 		JBrowse link
G NFU1 NFU1 iron-sulfur cluster scaffold decreases expression EXP tetrahydropalmatine results in decreased expression of NFU1 protein CTD PMID:20109541 NCBI chr 2:69,395,750...69,439,567
Ensembl chr 2:69,396,113...69,437,628 		JBrowse link
G NIPSNAP1 nipsnap homolog 1 increases expression EXP tetrahydropalmatine results in increased expression of NIPSNAP1 protein CTD PMID:20109541 NCBI chr22:29,554,808...29,581,113
Ensembl chr22:29,554,808...29,581,327 		JBrowse link
G NUBP2 NUBP iron-sulfur cluster assembly factor 2, cytosolic decreases expression EXP tetrahydropalmatine results in decreased expression of NUBP2 protein CTD PMID:20109541 NCBI chr16:1,782,960...1,789,186
Ensembl chr16:1,782,932...1,789,186 		JBrowse link
G NUFIP2 nuclear FMR1 interacting protein 2 decreases expression EXP tetrahydropalmatine results in decreased expression of NUFIP2 protein CTD PMID:20109541 NCBI chr17:29,255,839...29,294,148
Ensembl chr17:29,255,839...29,294,148 		JBrowse link
G NUP155 nucleoporin 155 decreases expression EXP tetrahydropalmatine results in decreased expression of NUP155 protein CTD PMID:20109541 NCBI chr 5:37,288,137...37,371,106
Ensembl chr 5:37,288,137...37,371,106 		JBrowse link
G PALLD palladin, cytoskeletal associated protein decreases expression EXP tetrahydropalmatine results in decreased expression of PALLD protein CTD PMID:20109541 NCBI chr 4:168,497,052...168,928,441
Ensembl chr 4:168,497,052...168,928,457 		JBrowse link
G PAWR pro-apoptotic WT1 regulator decreases expression EXP tetrahydropalmatine results in decreased expression of PAWR protein CTD PMID:20109541 NCBI chr12:79,584,879...79,690,964
Ensembl chr12:79,574,979...79,690,964 		JBrowse link
G PDS5A PDS5 cohesin associated factor A increases expression EXP tetrahydropalmatine results in increased expression of PDS5A protein CTD PMID:20109541 NCBI chr 4:39,822,863...39,977,911
Ensembl chr 4:39,822,863...39,977,956 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein increases expression EXP tetrahydropalmatine results in increased expression of PICALM protein CTD PMID:20109541 NCBI chr11:85,957,175...86,069,860
Ensembl chr11:85,957,175...86,069,882 		JBrowse link
G PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 decreases expression EXP tetrahydropalmatine results in decreased expression of PIN1 protein CTD PMID:20109541 NCBI chr19:9,835,318...9,849,689
Ensembl chr19:9,835,257...9,849,689 		JBrowse link
G POTEKP POTE ankyrin domain family member K, pseudogene decreases expression EXP tetrahydropalmatine results in decreased expression of POTEKP protein CTD PMID:20109541 NCBI chr 2:131,592,042...131,626,429
Ensembl chr 2:131,591,752...131,628,147 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO tetrahydropalmatine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PPARG mRNA] CTD PMID:37606869 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PPIL3 peptidylprolyl isomerase like 3 decreases expression EXP tetrahydropalmatine results in decreased expression of PPIL3 protein CTD PMID:20109541 NCBI chr 2:200,870,907...200,889,291
Ensembl chr 2:200,870,907...200,889,303 		JBrowse link
G PPP2CB protein phosphatase 2 catalytic subunit beta decreases expression EXP tetrahydropalmatine results in decreased expression of PPP2CB protein CTD PMID:20109541 NCBI chr 8:30,785,616...30,812,818
Ensembl chr 8:30,774,457...30,814,314 		JBrowse link
G PRAF2 PRA1 domain family member 2 increases expression EXP tetrahydropalmatine results in increased expression of PRAF2 protein CTD PMID:20109541 NCBI chr  X:49,071,161...49,074,002
Ensembl chr  X:49,071,161...49,074,002 		JBrowse link
G PRKAR1A protein kinase cAMP-dependent type I regulatory subunit alpha decreases expression EXP tetrahydropalmatine results in decreased expression of PRKAR1A protein CTD PMID:20109541 NCBI chr17:68,413,623...68,551,316
Ensembl chr17:68,511,780...68,551,319 		JBrowse link
G PRKCA protein kinase C alpha decreases expression EXP tetrahydropalmatine results in decreased expression of PRKCA protein CTD PMID:20109541 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743 		JBrowse link
G PRPF4 pre-mRNA splicing tri-snRNP complex factor PRPF4 decreases expression EXP tetrahydropalmatine results in decreased expression of PRPF4 protein CTD PMID:20109541 NCBI chr 9:113,275,658...113,292,905
Ensembl chr 9:113,275,642...113,294,009 		JBrowse link
G PRPSAP1 phosphoribosyl pyrophosphate synthetase associated protein 1 decreases expression EXP tetrahydropalmatine results in decreased expression of PRPSAP1 protein CTD PMID:20109541 NCBI chr17:76,309,478...76,354,198
Ensembl chr17:76,309,478...76,384,521 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression ISO tetrahydropalmatine results in decreased expression of PTGS2 mRNA CTD PMID:37606869 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G PYM1 PYM homolog 1, exon junction complex associated factor decreases expression EXP tetrahydropalmatine results in decreased expression of PYM1 protein CTD PMID:20109541 NCBI chr12:55,901,413...55,927,894
Ensembl chr12:55,901,413...55,932,618 		JBrowse link
G RAB3GAP1 RAB3 GTPase activating protein catalytic subunit 1 decreases expression EXP tetrahydropalmatine results in decreased expression of RAB3GAP1 protein CTD PMID:20109541 NCBI chr 2:135,052,292...135,176,396
Ensembl chr 2:135,052,289...135,176,667 		JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase increases expression EXP tetrahydropalmatine results in increased expression of RAF1 protein CTD PMID:20109541 NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,582,101...12,664,201 		JBrowse link
G RANBP2 RAN binding protein 2 decreases expression EXP tetrahydropalmatine results in decreased expression of RANBP2 protein CTD PMID:20109541 NCBI chr 2:108,719,482...109,842,301
Ensembl chr 2:108,719,482...108,785,810 		JBrowse link
G RBM39 RNA binding motif protein 39 decreases expression
increases expression		 EXP tetrahydropalmatine results in decreased expression of RBM39 protein
tetrahydropalmatine results in increased expression of RBM39 protein		 CTD PMID:20109541 NCBI chr20:35,701,347...35,742,260
Ensembl chr20:35,701,347...35,742,312 		JBrowse link
G REEP5 receptor accessory protein 5 decreases expression EXP tetrahydropalmatine results in decreased expression of REEP5 protein CTD PMID:20109541 NCBI chr 5:112,876,385...112,922,227
Ensembl chr 5:112,876,385...112,922,289 		JBrowse link
G RFC4 replication factor C subunit 4 increases expression EXP tetrahydropalmatine results in increased expression of RFC4 protein CTD PMID:20109541 NCBI chr 3:186,789,900...186,806,482
Ensembl chr 3:186,789,880...186,807,058 		JBrowse link
G RHOB ras homolog family member B decreases expression EXP tetrahydropalmatine results in decreased expression of RHOB protein CTD PMID:20109541 NCBI chr 2:20,447,074...20,449,440
Ensembl chr 2:20,447,074...20,449,440 		JBrowse link
G RMND5A required for meiotic nuclear division 5 homolog A increases expression EXP tetrahydropalmatine results in increased expression of RMND5A protein CTD PMID:20109541 NCBI chr 2:86,720,291...86,778,041
Ensembl chr 2:86,720,291...86,778,041 		JBrowse link
G RNF40 ring finger protein 40 decreases expression EXP tetrahydropalmatine results in decreased expression of RNF40 protein CTD PMID:20109541 NCBI chr16:30,761,612...30,776,307
Ensembl chr16:30,761,745...30,776,307 		JBrowse link
G ROCK2 Rho associated coiled-coil containing protein kinase 2 decreases expression EXP tetrahydropalmatine results in decreased expression of ROCK2 protein CTD PMID:20109541 NCBI chr 2:11,179,759...11,345,437
Ensembl chr 2:11,179,759...11,348,330 		JBrowse link
G RPA2 replication protein A2 decreases expression EXP tetrahydropalmatine results in decreased expression of RPA2 protein CTD PMID:20109541 NCBI chr 1:27,891,524...27,914,797
Ensembl chr 1:27,891,524...27,914,746 		JBrowse link
G RPS28 ribosomal protein S28 decreases expression EXP tetrahydropalmatine results in decreased expression of RPS28 protein CTD PMID:20109541 NCBI chr19:8,321,496...8,323,340
Ensembl chr19:8,321,158...8,323,340 		JBrowse link
G RPS6KA3 ribosomal protein S6 kinase A3 increases expression EXP tetrahydropalmatine results in increased expression of RPS6KA3 protein CTD PMID:20109541 NCBI chr  X:20,149,911...20,267,097
Ensembl chr  X:20,149,911...20,267,519 		JBrowse link
G SEPTIN11 septin 11 decreases expression EXP tetrahydropalmatine results in decreased expression of SEPTIN11 protein CTD PMID:20109541 NCBI chr 4:76,949,752...77,040,154
Ensembl chr 4:76,949,751...77,040,384 		JBrowse link
G SKIC3 SKI3 subunit of superkiller complex decreases expression EXP tetrahydropalmatine results in decreased expression of SKIC3 protein CTD PMID:20109541 NCBI chr 5:95,463,894...95,554,977
Ensembl chr 5:95,461,755...95,555,050 		JBrowse link
G SLC22A1 solute carrier family 22 member 1 multiple interactions EXP tetrahydropalmatine inhibits the reaction [SLC22A1 protein results in increased uptake of Monocrotaline]; tetrahydropalmatine inhibits the reaction [SLC22A1 protein results in increased uptake of retrorsine] CTD PMID:23831208 PMID:24799337 NCBI chr 6:160,121,815...160,158,718
Ensembl chr 6:160,121,815...160,158,718 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP tetrahydropalmatine inhibits the reaction [SLC22A2 protein results in increased import of Oxaliplatin] CTD PMID:34252480 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638 		JBrowse link
G SLC22A4 solute carrier family 22 member 4 multiple interactions EXP tetrahydropalmatine inhibits the reaction [SLC22A4 protein results in increased import of Oxaliplatin] CTD PMID:34252480 NCBI chr 5:132,294,394...132,344,190
Ensembl chr 5:132,294,394...132,344,190 		JBrowse link
G SLC22A5 solute carrier family 22 member 5 multiple interactions EXP tetrahydropalmatine inhibits the reaction [SLC22A5 protein results in increased import of Oxaliplatin] CTD PMID:34252480 NCBI chr 5:132,369,710...132,395,612
Ensembl chr 5:132,369,710...132,395,613 		JBrowse link
G SLC25A10 solute carrier family 25 member 10 increases expression EXP tetrahydropalmatine results in increased expression of SLC25A10 protein CTD PMID:20109541 NCBI chr17:81,712,284...81,721,012
Ensembl chr17:81,712,236...81,721,016 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 decreases expression ISO tetrahydropalmatine results in decreased expression of SLC6A4 mRNA CTD PMID:37606869 NCBI chr17:30,194,319...30,235,697
Ensembl chr17:30,194,319...30,236,002 		JBrowse link
G SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 decreases expression EXP tetrahydropalmatine results in decreased expression of SMARCA5 protein CTD PMID:20109541 NCBI chr 4:143,513,702...143,557,486
Ensembl chr 4:143,513,702...143,557,486 		JBrowse link
G SMS spermine synthase decreases expression EXP tetrahydropalmatine results in decreased expression of SMS protein CTD PMID:20109541 NCBI chr  X:21,940,709...21,994,837
Ensembl chr  X:21,940,709...21,994,837 		JBrowse link
G SNCG synuclein gamma decreases expression EXP tetrahydropalmatine results in decreased expression of SNCG protein CTD PMID:20109541 NCBI chr10:86,955,759...86,963,258
Ensembl chr10:86,958,599...86,963,258 		JBrowse link
G SNRPE small nuclear ribonucleoprotein polypeptide E decreases expression EXP tetrahydropalmatine results in decreased expression of SNRPE protein CTD PMID:20109541 NCBI chr 1:203,861,599...203,871,152
Ensembl chr 1:203,861,599...203,871,152 		JBrowse link
G SNW1 SNW domain containing 1 decreases expression EXP tetrahydropalmatine results in decreased expression of SNW1 protein CTD PMID:20109541 NCBI chr14:77,717,599...77,761,156
Ensembl chr14:77,717,599...77,761,207 		JBrowse link
G SNX1 sorting nexin 1 decreases expression EXP tetrahydropalmatine results in decreased expression of SNX1 protein CTD PMID:20109541 NCBI chr15:64,095,982...64,144,231
Ensembl chr15:64,094,123...64,146,090 		JBrowse link
G SNX2 sorting nexin 2 decreases expression EXP tetrahydropalmatine results in decreased expression of SNX2 protein CTD PMID:20109541 NCBI chr 5:122,774,996...122,834,543
Ensembl chr 5:122,775,079...122,834,543 		JBrowse link
G SPDL1 spindle apparatus coiled-coil protein 1 decreases expression EXP tetrahydropalmatine results in decreased expression of SPDL1 protein CTD PMID:20109541 NCBI chr 5:169,583,773...169,604,778
Ensembl chr 5:169,583,636...169,604,778 		JBrowse link
G SRI sorcin decreases expression EXP tetrahydropalmatine results in decreased expression of SRI protein CTD PMID:20109541 NCBI chr 7:88,205,115...88,226,976
Ensembl chr 7:88,205,115...88,226,993 		JBrowse link
G SRP19 signal recognition particle 19 decreases expression EXP tetrahydropalmatine results in decreased expression of SRP19 protein CTD PMID:20109541 NCBI chr 5:112,861,287...112,898,371
Ensembl chr 5:112,861,188...112,898,371 		JBrowse link
G SRP68 signal recognition particle 68 decreases expression EXP tetrahydropalmatine results in decreased expression of SRP68 protein CTD PMID:20109541 NCBI chr17:76,038,785...76,072,517
Ensembl chr17:76,038,775...76,072,517 		JBrowse link
G SRPRA SRP receptor subunit alpha decreases expression EXP tetrahydropalmatine results in decreased expression of SRPRA protein CTD PMID:20109541 NCBI chr11:126,235,930...126,268,895
Ensembl chr11:126,262,938...126,269,144 		JBrowse link
G STAT1 signal transducer and activator of transcription 1 increases expression EXP tetrahydropalmatine results in increased expression of STAT1 protein CTD PMID:20109541 NCBI chr 2:190,969,149...191,014,171
Ensembl chr 2:190,908,460...191,020,960 		JBrowse link
G STXBP1 syntaxin binding protein 1 decreases expression EXP tetrahydropalmatine results in decreased expression of STXBP1 protein CTD PMID:20109541 NCBI chr 9:127,611,912...127,696,029
Ensembl chr 9:127,579,370...127,696,027 		JBrowse link
G SWAP70 switching B cell complex subunit SWAP70 increases expression EXP tetrahydropalmatine results in increased expression of SWAP70 protein CTD PMID:20109541 NCBI chr11:9,664,077...9,752,993
Ensembl chr11:9,664,077...9,752,993 		JBrowse link
G SYVN1 synoviolin 1 decreases expression EXP tetrahydropalmatine results in decreased expression of SYVN1 protein CTD PMID:20109541 NCBI chr11:65,127,279...65,134,519
Ensembl chr11:65,121,780...65,134,532 		JBrowse link
G TMA7 translation machinery associated 7 homolog decreases expression EXP tetrahydropalmatine results in decreased expression of TMA7 protein CTD PMID:20109541 NCBI chr 3:48,440,257...48,444,208
Ensembl chr 3:48,440,257...48,444,208 		JBrowse link
G TMED4 transmembrane p24 trafficking protein 4 decreases expression EXP tetrahydropalmatine results in decreased expression of TMED4 protein CTD PMID:20109541 NCBI chr 7:44,577,894...44,582,231
Ensembl chr 7:44,577,894...44,582,287 		JBrowse link
G TOP1 DNA topoisomerase I increases expression EXP tetrahydropalmatine results in increased expression of TOP1 protein CTD PMID:20109541 NCBI chr20:41,028,822...41,124,487
Ensembl chr20:41,028,822...41,124,487 		JBrowse link
G TSNAX translin associated factor X decreases expression EXP tetrahydropalmatine results in decreased expression of TSNAX protein CTD PMID:20109541 NCBI chr 1:231,528,669...231,566,524
Ensembl chr 1:231,528,541...231,566,524 		JBrowse link
G TSR2 TSR2 ribosome maturation factor increases expression EXP tetrahydropalmatine results in increased expression of TSR2 protein CTD PMID:20109541 NCBI chr  X:54,440,404...54,448,032
Ensembl chr  X:54,440,404...54,448,032 		JBrowse link
G UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 increases expression EXP tetrahydropalmatine results in increased expression of UAP1 protein CTD PMID:20109541 NCBI chr 1:162,561,531...162,601,240
Ensembl chr 1:162,561,722...162,601,240 		JBrowse link
G UGT1A7 UDP glucuronosyltransferase family 1 member A7 increases expression EXP tetrahydropalmatine results in increased expression of UGT1A7 protein CTD PMID:20109541 NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300 		JBrowse link
G VPS45 vacuolar protein sorting 45 homolog increases expression EXP tetrahydropalmatine results in increased expression of VPS45 protein CTD PMID:20109541 NCBI chr 1:150,067,382...150,145,329
Ensembl chr 1:150,067,279...150,145,329 		JBrowse link
G WDHD1 WD repeat and HMG-box DNA binding protein 1 increases expression EXP tetrahydropalmatine results in increased expression of WDHD1 protein CTD PMID:20109541 NCBI chr14:54,938,949...55,027,099
Ensembl chr14:54,938,949...55,027,105 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    role 25957
      biological role 25936
        pharmacological role 22068
          analgesic 15553
            non-narcotic analgesic 14427
              tetrahydropalmatine 163
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    p-block element atom 25841
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            organic molecule 25228
                              organic cyclic compound 24281
                                organic heterocyclic compound 22324
                                  organonitrogen heterocyclic compound 20345
                                    dibenzoquinolizine 432
                                      berberine alkaloid 432
                                        palmatine 185
                                          tetrahydropalmatine 163
paths to the root