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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chlordecone
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Accession:CHEBI:16548 term browser browse the term
Definition:An organochlorine compound with insecticidal activity.
Synonyms:exact_synonym: 1,1a,3,3a,4,5,5,5a,5b,6-decachlorooctahydro-2H-1,3,4-(methanetriyl)cyclobuta[cd]pentalen-2-one
 related_synonym: 1,2,3,4,6,7,8,9,10,10-decachloropentacyclo[5.3.0.0(2,6).0(3,9).0(4,8)]decan-5-one;   Formula=C10Cl10O;   GC 1189;   InChI=1S/C10Cl10O/c11-2-1(21)3(12)6(15)4(2,13)8(17)5(2,14)7(3,16)9(6,18)10(8,19)20;   InChIKey=LHHGDZSESBACKH-UHFFFAOYSA-N;   Kepone;   SMILES=ClC1(Cl)C2(Cl)C3(Cl)C4(Cl)C(=O)C5(Cl)C3(Cl)C1(Cl)C5(Cl)C24Cl;   decachloropentacyclo[5.2.1.0(2,6).0(3,9).0(5,8)]decan-4-one;   perchloropentacyclo[5.3.0.0(2,6).0(3,9).0(4,8)]decan-5-one
 alt_id: CHEBI:13968;   CHEBI:23110;   CHEBI:3609
 xref: AGR:IND44714295;   Beilstein:1894593;   CAS:143-50-0;   HMDB:HMDB0059603;   KEGG:C01792;   LINCS:LSM-36918
 xref_mesh: MESH:D007631
 xref: PMID:19167793;   PMID:20566993;   PMID:21852857;   PMID:22683396;   PMID:23706897;   PMID:23827360;   PMID:24401561;   PPDB:1293;   Patent:US2616825;   Patent:US2616928;   Reaxys:1894593;   Wikipedia:Kepone


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chlordecone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO Chlordecone results in decreased activity of ABCB1 protein CTD PMID:24464585 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity ISO Chlordecone results in decreased activity of ABCC2 protein CTD PMID:24464585 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases activity ISO Chlordecone results in decreased activity of ABCG2 protein CTD PMID:24464585 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Chlordecone promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:26853152 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Acyp2 acylphosphatase 2 affects response to substance ISO ACYP2 gene SNP affects the susceptibility to Chlordecone CTD PMID:25622337 NCBI chr14:114,891,245...115,052,497
Ensembl chr14:114,891,246...115,052,450
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases reduction ISO AKR1C4 protein results in increased reduction of Chlordecone CTD PMID:2427522, PMID:11158055 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Alb albumin affects binding ISO
EXP
Chlordecone binds to ALB protein CTD PMID:6174734 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Apoa1 apolipoprotein A1 affects localization ISO Chlordecone affects the localization of APOA1 protein CTD PMID:18789348 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Ar androgen receptor affects binding
multiple interactions
ISO
EXP
Chlordecone binds to AR protein
Chlordecone inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; Chlordecone inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]
CTD PMID:10696776, PMID:14565775, PMID:15253041, PMID:29162470 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arhgef3 Rho guanine nucleotide exchange factor 3 affects response to substance ISO ARHGEF3 gene SNP affects the susceptibility to Chlordecone CTD PMID:25622337 NCBI chr16:2,743,714...3,026,768
Ensembl chr16:2,743,823...3,026,760
JBrowse link
G Atxn7l1 ataxin 7-like 1 affects response to substance ISO ATXN7L1 gene SNP affects the susceptibility to Chlordecone CTD PMID:25622337 NCBI chr 6:52,459,930...52,680,552
Ensembl chr 6:52,459,946...52,675,574
JBrowse link
G B3galt5 Beta-1,3-galactosyltransferase 5 decreases expression ISO Chlordecone results in decreased expression of B3GALT5 protein CTD PMID:22906706 NCBI chr11:36,638,067...36,683,915
Ensembl chr11:36,634,662...36,683,672
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO Chlordecone results in increased expression of BCL2 mRNA CTD PMID:17578864 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Caln1 calneuron 1 affects response to substance ISO CALN1 gene SNP affects the susceptibility to Chlordecone CTD PMID:25622337 NCBI chr12:29,307,117...29,796,996
Ensembl chr12:29,308,341...29,743,705
JBrowse link
G Ccn5 cellular communication network factor 5 increases expression
multiple interactions
ISO Chlordecone results in increased expression of CCN5 mRNA
ESR1 protein inhibits the reaction [Chlordecone results in increased expression of CCN5 mRNA]
CTD PMID:23384675 NCBI chr 3:160,207,969...160,219,316
Ensembl chr 3:160,207,913...160,219,331
JBrowse link
G Cdh1 cadherin 1 multiple interactions
decreases expression
ISO Chlordecone inhibits the reaction [CDH1 protein binds to JUP protein]
Chlordecone results in decreased expression of CDH1 protein
CTD PMID:11695219 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh4 cadherin 4 affects response to substance ISO CDH4 gene SNP affects the susceptibility to Chlordecone CTD PMID:25622337 NCBI chr 3:175,220,520...175,283,144
Ensembl chr 3:175,144,495...175,279,761
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions ISO [Chlordecone co-treated with Carbon Tetrachloride] results in increased expression of COL1A2 mRNA CTD PMID:26853152 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO Chlordecone results in decreased expression of CTNNB1 protein CTD PMID:11695219 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO Chlordecone results in increased expression of CXCR4 protein CTD PMID:17578864 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cxcr5 C-X-C motif chemokine receptor 5 increases expression ISO Chlordecone results in increased expression of CXCR5 protein CTD PMID:17578864 NCBI chr 8:48,835,688...48,852,032
Ensembl chr 8:48,836,957...48,850,671
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
decreases activity
ISO [Dichlorodiphenyl Dichloroethylene co-treated with Chlordecone] results in increased activity of CYP19A1 protein; bis(tri-n-butyltin)oxide promotes the reaction [Chlordecone results in decreased activity of CYP19A1 protein]; bisphenol A promotes the reaction [Chlordecone results in decreased activity of CYP19A1 protein]; Chlordecone promotes the reaction [bis(tri-n-butyltin)oxide results in decreased activity of CYP19A1 protein]; Chlordecone promotes the reaction [nonylphenol results in decreased activity of CYP19A1 protein]; nonylphenol promotes the reaction [Chlordecone results in decreased activity of CYP19A1 protein] CTD PMID:17599374 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression
multiple interactions
EXP
ISO
Chlordecone results in increased expression of CYP2B1 mRNA
Chlordecone results in increased expression of and results in increased activity of CYP2B10 protein
Chlordecone inhibits the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA]
CTD PMID:7513451, PMID:8722114 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions
increases expression
EXP Chlordecone inhibits the reaction [Phenobarbital results in increased expression of CYP2B2 mRNA]
Chlordecone results in increased expression of CYP2B2 mRNA
CTD PMID:1715015, PMID:7513451 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Chlordecone results in increased expression of CYP2B6 protein CTD PMID:15548381 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO Chlordecone results in decreased activity of DIO1 protein CTD PMID:30561685 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO Chlordecone results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity ISO Chlordecone results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138
JBrowse link
G Eno1 enolase 1 decreases expression ISO Chlordecone results in decreased expression of ENO1 protein CTD PMID:19666090 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Esr1 estrogen receptor 1 increases activity
increases expression
multiple interactions
affects binding
ISO Chlordecone results in increased activity of ESR1 protein mutant form
Chlordecone results in increased expression of ESR1 protein
Chlordecone promotes the reaction [ESR1 protein binds to HSPA5 protein]; ESR1 protein affects the reaction [HSPA5 protein results in increased susceptibility to Chlordecone]
Chlordecone binds to ESR1 protein
Chlordecone binds to and results in increased activity of ESR1 protein; Chlordecone inhibits the reaction [Estradiol binds to ESR1 protein]; ESR1 protein inhibits the reaction [Chlordecone results in increased expression of CCN5 mRNA]
CTD PMID:9751507, PMID:10774817, PMID:11162928, PMID:14579009, PMID:15026083, PMID:15253041, PMID:16626760, PMID:17141713, PMID:17640991, PMID:19913605, PMID:23384675, PMID:25012808, PMID:29162470 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding
ISO Chlordecone binds to and results in decreased activity of ESR2 protein; Chlordecone inhibits the reaction [Estradiol binds to ESR2 protein]
Chlordecone binds to ESR2 protein
CTD PMID:9751507, PMID:12224631, PMID:16626760 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fmn2 formin 2 affects response to substance ISO FMN2 gene SNP affects the susceptibility to Chlordecone CTD PMID:25622337 NCBI chr13:92,569,256...92,887,302 JBrowse link
G Foxp2 forkhead box P2 affects response to substance ISO FOXP2 gene SNP affects the susceptibility to Chlordecone CTD PMID:25622337 NCBI chr 4:41,364,441...41,944,685
Ensembl chr 4:41,364,441...41,942,023
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions ISO Chlordecone binds to and results in increased activity of GPER1 protein CTD PMID:17088055 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Chlordecone promotes the reaction [Carbon Tetrachloride results in increased activity of GPT protein] CTD PMID:26853152 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
increases response to substance
multiple interactions
ISO Chlordecone results in increased expression of HSPA5 mRNA; Chlordecone results in increased expression of HSPA5 protein
HSPA5 protein results in increased susceptibility to Chlordecone
[Chlordecone co-treated with fulvestrant] results in increased expression of HSPA5 protein; Chlordecone promotes the reaction [ESR1 protein binds to HSPA5 protein]; ESR1 protein affects the reaction [HSPA5 protein results in increased susceptibility to Chlordecone]
CTD PMID:17640991 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Chlordecone results in increased expression of ICAM1 protein CTD PMID:17578864 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifi35 interferon-induced protein 35 affects response to substance ISO IFI35 gene SNP affects the susceptibility to Chlordecone CTD PMID:25622337 NCBI chr10:89,358,376...89,366,628
Ensembl chr10:89,358,376...89,366,626
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Chlordecone inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA] CTD PMID:18177342 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Jup junction plakoglobin multiple interactions ISO Chlordecone inhibits the reaction [CDH1 protein binds to JUP protein] CTD PMID:11695219 NCBI chr10:88,280,517...88,307,451
Ensembl chr10:88,279,632...88,307,412
JBrowse link
G Ltf lactotransferrin multiple interactions
increases expression
ISO fulvestrant inhibits the reaction [Chlordecone results in increased expression of LTF mRNA] CTD PMID:9371753, PMID:9607801 NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261
JBrowse link
G Macrod2 mono-ADP ribosylhydrolase 2 affects response to substance ISO MACROD2 gene SNP affects the susceptibility to Chlordecone CTD PMID:25622337 NCBI chr 3:135,729,839...136,422,082 JBrowse link
G Marchf1 membrane associated ring-CH-type finger 1 affects response to substance ISO MARCHF1 gene SNP affects the susceptibility to Chlordecone CTD PMID:25622337 NCBI chr16:24,998,709...25,856,327
Ensembl chr16:25,001,666...25,192,675
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [Chlordecone co-treated with Carbon Tetrachloride] results in increased expression of MMP2 mRNA CTD PMID:26853152 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Chlordecone inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein] CTD PMID:17015962 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nkain3 Sodium/potassium transporting ATPase interacting 3 affects response to substance ISO NKAIN3 gene SNP affects the susceptibility to Chlordecone CTD PMID:25622337 NCBI chr 5:34,133,596...34,813,668
Ensembl chr 5:34,174,411...34,813,116
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO Chlordecone binds to and results in increased activity of NR1I2 protein
Chlordecone results in increased activity of NR1I2 protein
CTD PMID:15548381, PMID:16054614 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Olfml2a olfactomedin-like 2A affects response to substance ISO OLFML2A gene SNP affects the susceptibility to Chlordecone CTD PMID:25622337 NCBI chr 3:23,223,468...23,259,318
Ensembl chr 3:23,223,479...23,259,321
JBrowse link
G Pgr progesterone receptor affects binding
increases expression
multiple interactions
ISO
EXP
Chlordecone binds to PGR protein
Chlordecone results in increased expression of PGR mRNA
fulvestrant affects the reaction [Chlordecone results in increased expression of PGR mRNA]
Chlordecone inhibits the reaction [Progesterone binds to PGR protein]
CTD PMID:9607801, PMID:10774817, PMID:14579009 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO Chlordecone results in decreased expression of POU5F1 protein CTD PMID:22906706 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Prdx1 peroxiredoxin 1 decreases expression ISO Chlordecone results in decreased expression of PRDX1 protein CTD PMID:19666090 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Prkcb protein kinase C, beta multiple interactions
increases activity
ISO Calcium inhibits the reaction [Chlordecone results in increased activity of PRKCB protein]; Phosphatidylserines promotes the reaction [Chlordecone results in increased activity of PRKCB protein] CTD PMID:1724372 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 increases expression ISO Chlordecone results in increased expression of PTPN6 mRNA CTD PMID:17578864 NCBI chr 4:157,239,141...157,263,890
Ensembl chr 4:157,239,142...157,263,890
JBrowse link
G Rimklb ribosomal modification protein rimK-like family member B affects response to substance ISO RIMKLB gene SNP affects the susceptibility to Chlordecone CTD PMID:25622337 NCBI chr 4:155,258,241...155,292,809
Ensembl chr 4:155,260,103...155,275,161
JBrowse link
G Rph3al rabphilin 3A-like (without C2 domains) affects response to substance ISO RPH3AL gene SNP affects the susceptibility to Chlordecone CTD PMID:25622337 NCBI chr10:63,989,556...64,140,584
Ensembl chr10:63,989,644...64,108,554
JBrowse link
G Scarb2 scavenger receptor class B, member 2 affects localization ISO Chlordecone affects the localization of SCARB2 protein CTD PMID:19666090 NCBI chr14:17,064,173...17,115,620
Ensembl chr14:17,064,353...17,115,963
JBrowse link
G Selenbp1 selenium binding protein 1 decreases expression ISO Chlordecone results in decreased expression of SELENBP1 protein CTD PMID:19666090 NCBI chr 2:196,105,592...196,146,474
Ensembl chr 2:196,105,569...196,113,149
JBrowse link
G Slc15a5 solute carrier family 15, member 5 affects response to substance ISO SLC15A5 gene SNP affects the susceptibility to Chlordecone CTD PMID:25622337 NCBI chr 4:171,970,620...172,063,391
Ensembl chr 4:171,970,620...172,063,391
JBrowse link
G Spon1 spondin 1 affects response to substance ISO SPON1 gene SNP affects the susceptibility to Chlordecone CTD PMID:25622337 NCBI chr 1:178,568,777...178,935,715
Ensembl chr 1:178,636,544...178,935,051
JBrowse link
G Stard13 StAR-related lipid transfer domain containing 13 affects response to substance ISO STARD13 gene SNP affects the susceptibility to Chlordecone CTD PMID:25622337 NCBI chr12:1,023,494...1,418,919
Ensembl chr12:1,023,531...1,195,591
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO [Chlordecone co-treated with Carbon Tetrachloride] results in increased expression of TIMP1 mRNA CTD PMID:26853152 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Troap trophinin associated protein affects response to substance ISO TROAP gene SNP affects the susceptibility to Chlordecone CTD PMID:25622337 NCBI chr 7:140,758,576...140,766,423
Ensembl chr 7:140,758,615...140,766,423
JBrowse link
G Vat1l vesicle amine transport 1-like affects response to substance ISO VAT1L gene SNP affects the susceptibility to Chlordecone CTD PMID:25622337 NCBI chr19:46,525,895...46,693,838
Ensembl chr19:46,525,919...46,693,838
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO Chlordecone results in increased expression of VCAM1 protein CTD PMID:17578864 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      application 19385
        pesticide 16285
          insecticide 13443
            chlordecone 64
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19571
                        carbon atom 19560
                          organic molecular entity 19560
                            organic group 18508
                              organic divalent group 18501
                                organodiyl group 18501
                                  carbonyl group 18404
                                    carbonyl compound 18404
                                      ketone 16152
                                        cyclic ketone 13818
                                          chlordecone 64
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.