Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:taurochenodeoxycholic acid
go back to main search page
Accession:CHEBI:16525 term browser browse the term
Definition:A bile acid taurine conjugate of chenodeoxycholic acid.
Synonyms:exact_synonym: 2-[(3alpha,7alpha-dihydroxy-24-oxo-5beta-cholan-24-yl)amino]ethanesulfonic acid
 related_synonym: Chenodeoxycholoyltaurine;   Formula=C26H45NO6S;   InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1;   InChIKey=BHTRKEVKTKCXOH-BJLOMENOSA-N;   SMILES=[H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]1([H])CC[C@]3(C)[C@]([H])(CC[C@@]3([H])[C@]1([H])[C@H](O)C2)[C@H](C)CCC(=O)NCCS(O)(=O)=O;   taurine chenodeoxycholate;   taurochenodeoxycholate
 alt_id: CHEBI:13961;   CHEBI:23096;   CHEBI:3590;   CHEBI:46136
 xref: Beilstein:3228311;   CAS:516-35-8;   HMDB:HMDB0000951;   KEGG:C05465;   LIPID_MAPS_instance:LMST05040005
 xref_mesh: MESH:D013655
 xref: PDBeChem:TUD;   PMID:12065295;   PMID:21983642;   PMID:23510744;   PMID:23562588;   PMID:23811455;   Reaxys:3228311
 cyclic_relationship: is_conjugate_acid_of CHEBI:9407


show annotations for term's descendants           Sort by:
 
taurochenodeoxycholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 affects transport
increases expression
ISO
EXP
ABCB11 protein affects the transport of Taurochenodeoxycholic Acid
Taurochenodeoxycholic Acid results in increased expression of ABCB11 protein
CTD PMID:11343252, PMID:11672435 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP Taurochenodeoxycholic Acid results in increased expression of ABCC2 protein CTD PMID:11672435 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Taurochenodeoxycholic Acid results in increased expression of ABCC3 protein CTD PMID:11672435 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Ahr aryl hydrocarbon receptor increases secretion
increases abundance
ISO AHR gene mutant form results in increased secretion of Taurochenodeoxycholic Acid
AHR gene mutant form results in increased abundance of Taurochenodeoxycholic Acid
CTD PMID:32679164 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Fech ferrochelatase affects abundance ISO FECH protein affects the abundance of Taurochenodeoxycholic Acid CTD PMID:29906468 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Taurochenodeoxycholic Acid results in increased phosphorylation of and results in decreased activity of GSK3B protein CTD PMID:20512997 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO Taurochenodeoxycholic Acid inhibits the reaction [Cholera Toxin results in increased expression of HGF protein] CTD PMID:15802798 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Il10 interleukin 10 increases abundance ISO IL10 gene mutant form results in increased abundance of Taurochenodeoxycholic Acid CTD PMID:27580383 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Por cytochrome p450 oxidoreductase increases abundance ISO POR gene mutant form results in increased abundance of Taurochenodeoxycholic Acid CTD PMID:25034404 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Slc10a2 solute carrier family 10 member 2 increases expression EXP Taurochenodeoxycholic Acid results in increased expression of SLC10A2 protein CTD PMID:11672435 NCBI chr16:90,324,420...90,350,254
Ensembl chr16:90,324,361...90,345,865
JBrowse link
G Slc51a solute carrier family 51 subunit alpha multiple interactions ISO [SLC51A protein binds to SLC51B protein] which results in increased uptake of Taurochenodeoxycholic Acid; Fidaxomicin inhibits the reaction [[SLC51A protein binds to SLC51B protein] which results in increased uptake of Taurochenodeoxycholic Acid]; troglitazone sulfate inhibits the reaction [[SLC51A protein binds to SLC51B protein] which results in increased uptake of Taurochenodeoxycholic Acid] CTD PMID:32294204 NCBI chr11:71,533,078...71,547,476
Ensembl chr11:71,533,078...71,547,476
JBrowse link
G Slc51b solute carrier family 51 subunit beta multiple interactions ISO [SLC51A protein binds to SLC51B protein] which results in increased uptake of Taurochenodeoxycholic Acid; Fidaxomicin inhibits the reaction [[SLC51A protein binds to SLC51B protein] which results in increased uptake of Taurochenodeoxycholic Acid]; troglitazone sulfate inhibits the reaction [[SLC51A protein binds to SLC51B protein] which results in increased uptake of Taurochenodeoxycholic Acid] CTD PMID:32294204 NCBI chr 8:70,930,196...70,938,559
Ensembl chr 8:70,930,347...70,932,986
JBrowse link
G Smad3 SMAD family member 3 increases abundance ISO SMAD3 protein results in increased abundance of Taurochenodeoxycholic Acid CTD PMID:23034213 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression EXP Taurochenodeoxycholic Acid results in increased expression of TGFB1 protein CTD PMID:8743917 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor increases expression EXP Taurochenodeoxycholic Acid results in increased expression of TNF protein CTD PMID:8743917 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      chemical role 19288
        antioxidant 14226
          taurine 412
            bile acid taurine conjugate 279
              taurochenodeoxycholic acid 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic polycyclic compound 16395
                                  steroid 12800
                                    steroid fundamental parent 12413
                                      cholane 920
                                        cholanoid 920
                                          cholanic acids 919
                                            cholanic acid 919
                                              5beta-cholanic acid 919
                                                hydroxy-5beta-cholanic acid 919
                                                  dihydroxy-5beta-cholanic acid 767
                                                    chenodeoxycholic acid 449
                                                      taurochenodeoxycholic acid 15
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.