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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Paraoxon-methyl
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Accession:CHEBI:165199 term browser browse the term
Synonyms:exact_synonym: dimethyl (4-nitrophenyl) phosphate
 related_synonym: Formula=C8H10NO6P;   InChI=1S/C8H10NO6P/c1-13-16(12,14-2)15-8-5-3-7(4-6-8)9(10)11/h3-6H,1-2H3;   InChIKey=BAFQDKPJKOLXFZ-UHFFFAOYSA-N;   SMILES=P(OC1=CC=C([N+]([O-])=O)C=C1)(OC)(OC)=O
 xref: CAS:950-35-6;   Chemspider:13114
 xref_mesh: MESH:C008480


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Paraoxon-methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity
multiple interactions
EXP
ISO
methylparaoxon results in decreased activity of ACHE protein
4-(aminocarbonyl)-1-(3-(4-((E)-(hydroxyimino)methyl)pyridinium-1-yl)propyl)pyridinium dibromide inhibits the reaction [methylparaoxon results in decreased activity of ACHE protein]; asoxime chloride inhibits the reaction [methylparaoxon results in decreased activity of ACHE protein]; K-48 compound inhibits the reaction [methylparaoxon results in decreased activity of ACHE protein]; N,N'-monomethylenebis(pyridiniumaldoxime) inhibits the reaction [methylparaoxon results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [methylparaoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [methylparaoxon results in decreased activity of ACHE protein]
CTD PMID:12478623 PMID:17265452 PMID:18761328 PMID:18804659 PMID:22982773 PMID:26965078 PMID:27132127 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 multiple interactions
increases expression
ISO AKR1C2 protein affects the susceptibility to [Benzo(a)pyrene co-treated with methylparaoxon]
methylparaoxon results in increased expression of AKR1C2 mRNA
CTD PMID:19800895 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Alb albumin affects binding ISO methylparaoxon binds to ALB protein CTD PMID:15525694 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Bche butyrylcholinesterase affects activity ISO methylparaoxon affects the activity of BCHE protein CTD PMID:19428953 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO methylparaoxon results in increased expression of CDKN1A mRNA CTD PMID:18418871 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO methylparaoxon results in increased expression of CYP1A1 mRNA
methylparaoxon inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]
CTD PMID:19800895 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases chemical synthesis EXP CYP2C11 protein results in increased chemical synthesis of methylparaoxon CTD PMID:22271348 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases chemical synthesis EXP CYP3A23-3A1 protein results in increased chemical synthesis of methylparaoxon CTD PMID:22271348 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO methylparaoxon results in increased expression of GADD45A mRNA CTD PMID:18418871 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO methylparaoxon results in increased expression of MDM2 mRNA CTD PMID:18418871 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO methylparaoxon results in decreased expression of MKI67 protein CTD PMID:18418871 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Pon1 paraoxonase 1 multiple interactions EXP
ISO
[Calcium results in increased activity of PON1 protein] which results in decreased susceptibility to methylparaoxon; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to methylparaoxon CTD PMID:27132127 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Tp53 tumor protein p53 increases expression ISO methylparaoxon results in increased expression of TP53 mRNA CTD PMID:18418871 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    chemical entity 19883
      group 19795
        inorganic group 19228
          nitro group 7286
            nitro compound 7286
              C-nitro compound 6886
                Paraoxon-methyl 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic molecule 19596
                              C-nitro compound 6886
                                Paraoxon-methyl 13
paths to the root