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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1,4-benzoquinone
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Accession:CHEBI:16509 term browser browse the term
Definition:The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.
Synonyms:exact_synonym: cyclohexa-2,5-diene-1,4-dione
 related_synonym: 1,4-Benzochinon;   2,5-Cyclohexadiene-1,4-dione;   Formula=C6H4O2;   InChI=1S/C6H4O2/c7-5-1-2-6(8)4-3-5/h1-4H;   InChIKey=AZQWKYJCGOJGHM-UHFFFAOYSA-N;   Para-Benzoquinone;   Quinone;   SMILES=O=C1C=CC(=O)C=C1;   benzo-1,4-quinone;   benzoquinone;   p-Benzoquinone;   p-Chinon;   p-Quinone
 alt_id: CHEBI:12837;   CHEBI:15009;   CHEBI:18927;   CHEBI:49820;   CHEBI:8730
 xref: Beilstein:773967;   CAS:106-51-4;   Gmelin:2741;   HMDB:HMDB0003364;   KEGG:C00472;   KEGG:C15602
 xref_mesh: MESH:C004532
 xref: MetaCyc:P-BENZOQUINONE;   PDBeChem:PLQ;   PMID:10462055;   PMID:11304127;   PMID:1395635;   PMID:15182198;   PMID:15618234;   PMID:15920754;   PMID:16484134;   PMID:24023812;   PMID:25057895;   PMID:9118901;   Reaxys:773967;   UM-BBD_compID:c0261;   Wikipedia:1\,4-Benzoquinone


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1,4-benzoquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
affects localization
ISO AHR protein affects the reaction [quinone results in increased expression of CYP1A1 mRNA]
quinone affects the localization of AHR protein
CTD PMID:26558468, PMID:27853106 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO quinone results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Alb albumin affects binding
multiple interactions
ISO
EXP
ALB protein binds to quinone; quinone binds to ALB protein
Benzene promotes the reaction [ALB protein binds to quinone]
Benzene promotes the reaction [quinone binds to ALB protein]
CTD PMID:9826945, PMID:10746935, PMID:11489749, PMID:11888901, PMID:16484134, PMID:17366815, PMID:22154986 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Bach1 BTB domain and CNC homolog 1 multiple interactions
affects localization
ISO quinone promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of BACH1 protein]
quinone affects the localization of BACH1 protein
CTD PMID:28645578 NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO quinone results in increased expression of BAX protein CTD PMID:20499891 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO quinone results in decreased expression of BCL2 protein
[HIF1A protein co-treated with quinone] results in increased expression of BCL2 protein
CTD PMID:20499891, PMID:30448556 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression
ISO Cyclosporine inhibits the reaction [quinone results in increased expression of BECN1 protein] CTD PMID:29567065 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger increases expression ISO quinone results in increased expression of BMI1 mRNA CTD PMID:28986286 NCBI chr17:85,360,439...85,370,283
Ensembl chr17:85,364,483...85,368,208
JBrowse link
G Casp1 caspase 1 decreases activity ISO quinone results in decreased activity of CASP1 protein CTD PMID:9118901 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 decreases activity
multiple interactions
increases activity
ISO quinone results in decreased activity of CASP3 protein
[quinone results in increased abundance of Reactive Oxygen Species] which results in decreased activity of CASP3 protein
quinone results in increased activity of CASP3 protein
CTD PMID:15337166, PMID:17051661, PMID:20499891, PMID:22960397 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 decreases activity ISO quinone results in decreased activity of CASP7 protein CTD PMID:22960397 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
ISO Cyclosporine inhibits the reaction [quinone results in increased expression of CASP9 protein] CTD PMID:29567065 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
decreases response to substance
increases expression
ISO CAT protein inhibits the reaction [quinone results in increased abundance of Reactive Oxygen Species]; CAT protein inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CAT protein inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CAT protein results in decreased susceptibility to quinone
quinone results in increased expression of CAT protein
CTD PMID:10193577, PMID:15795063, PMID:25437431 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 increases expression ISO quinone results in increased expression of CCL11 protein CTD PMID:17572062 NCBI chr10:69,434,965...69,439,566
Ensembl chr10:69,434,941...69,439,575
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO quinone results in increased expression of CCL2 protein CTD PMID:17572062 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO quinone results in increased expression of CCL3 protein CTD PMID:17572062 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO quinone results in increased expression of CCL4 protein CTD PMID:17572062 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO quinone results in increased expression of CCL5 protein CTD PMID:17572062 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cd80 Cd80 molecule increases expression ISO quinone results in increased expression of CD80 protein CTD PMID:31958493 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
JBrowse link
G Cd86 CD86 molecule increases expression ISO quinone results in increased expression of CD86 protein CTD PMID:31958493 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO quinone results in increased expression of CDKN1A mRNA CTD PMID:14976336 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cryaa crystallin, alpha A multiple interactions ISO quinone binds to and affects the folding of CRYAA protein CTD PMID:29196190 NCBI chr20:10,438,444...10,442,189
Ensembl chr20:10,438,444...10,442,187
JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions ISO quinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide] CTD PMID:7884313 NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO quinone promotes the reaction [[CSF2 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide] CTD PMID:7884313 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression ISO quinone results in increased expression of CXCL12 mRNA CTD PMID:22960397 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO quinone results in increased expression of CYP1A1 mRNA
AHR protein affects the reaction [quinone results in increased expression of CYP1A1 mRNA]
CTD PMID:20491607, PMID:26558468, PMID:27853106 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects expression EXP quinone affects the expression of CYP2B1 protein CTD PMID:10462055 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression EXP quinone results in decreased expression of CYP2E1 protein CTD PMID:10462055 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Dhrs7 dehydrogenase/reductase 7 increases reduction ISO DHRS7 protein results in increased reduction of quinone CTD PMID:24246760 NCBI chr 6:95,522,577...95,541,393
Ensembl chr 6:95,522,577...95,541,393
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 increases expression ISO quinone results in increased expression of DKK1 mRNA CTD PMID:22960397 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Gata3 GATA binding protein 3 increases expression ISO quinone results in increased expression of GATA3 mRNA CTD PMID:28986286 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Gbp1 guanylate binding protein 1 multiple interactions ISO quinone promotes the reaction [IFNG protein results in increased expression of GBP1 mRNA] CTD PMID:31248982 NCBI chr 2:248,343,334...248,423,402
Ensembl chr 2:248,398,917...248,409,570
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO quinone results in increased expression of GCLM protein CTD PMID:21059386 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gss glutathione synthetase increases expression
multiple interactions
ISO quinone results in increased expression of GSS protein
NFE2L2 mRNA affects the reaction [quinone results in increased expression of GSS protein]
CTD PMID:21059386 NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO quinone results in increased phosphorylation of H2AX protein CTD PMID:18835433, PMID:31340051 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
ISO [HIF1A protein co-treated with quinone] results in increased expression of BCL2 protein; [HIF1A protein co-treated with quinone] results in increased expression of LDHA protein; [HIF1A protein co-treated with quinone] results in increased expression of PDK1 protein; [HIF1A protein co-treated with quinone] results in increased expression of PFKFB3 protein; [HIF1A protein co-treated with quinone] results in increased expression of PFKL protein; [HIF1A protein co-treated with quinone] results in increased expression of PGK1 protein; [HIF1A protein co-treated with quinone] results in increased expression of PKM protein; [HIF1A protein co-treated with quinone] results in increased expression of SLC2A1 protein
quinone results in increased expression of HIF1A protein
CTD PMID:30448556 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO quinone results in increased expression of HMOX1 protein
NFE2L2 mRNA affects the reaction [quinone results in increased expression of HMOX1 protein]
CTD PMID:21059386, PMID:25437431, PMID:28645578 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hoxb4 homeo box B4 increases expression ISO quinone results in increased expression of HOXB4 mRNA CTD PMID:28986286 NCBI chr10:84,167,331...84,169,913
Ensembl chr10:84,167,331...84,169,907
JBrowse link
G Ifng interferon gamma multiple interactions ISO [IFNG protein co-treated with Lipopolysaccharides co-treated with quinone] results in increased abundance of Nitric Oxide; quinone inhibits the reaction [Amino Acids, Peptides, and Proteins results in increased expression of IFNG protein]
quinone promotes the reaction [IFNG protein results in increased expression of APOL1 mRNA]; quinone promotes the reaction [IFNG protein results in increased expression of GBP1 mRNA]; quinone promotes the reaction [IFNG protein results in increased expression of IRF1 mRNA]; quinone promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein]
CTD PMID:3137358, PMID:7884313, PMID:31248982 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions
increases secretion
ISO quinone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL10 protein]
quinone results in increased secretion of IL10 protein
CTD PMID:17572062, PMID:31958493 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B increases secretion ISO quinone results in increased secretion of IL12B protein CTD PMID:31958493 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il6 interleukin 6 increases expression ISO quinone results in increased expression of IL6 protein CTD PMID:17572062 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO quinone promotes the reaction [IFNG protein results in increased expression of IRF1 mRNA] CTD PMID:31248982 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
JBrowse link
G Jag1 jagged canonical Notch ligand 1 decreases expression ISO quinone results in decreased expression of JAG1 mRNA CTD PMID:22960397 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO quinone analog binds to and results in decreased activity of KDR protein CTD PMID:16302797 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Kitlg KIT ligand increases expression ISO quinone results in increased expression of KITLG mRNA CTD PMID:22960397 NCBI chr 7:42,269,784...42,351,054
Ensembl chr 7:42,269,784...42,351,054
JBrowse link
G Ldha lactate dehydrogenase A multiple interactions
increases expression
ISO [HIF1A protein co-treated with quinone] results in increased expression of LDHA protein
quinone results in increased expression of LDHA protein
CTD PMID:30448556 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO quinone results in increased expression of MAFF mRNA CTD PMID:20491607 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CAT protein inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; quinone results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:15795063 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK3 protein]; CAT protein inhibits the reaction [quinone results in increased phosphorylation of and results in increased activity of MAPK3 protein]; quinone results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:15795063 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO quinone promotes the reaction [MAPT protein binds to MAPT protein] CTD PMID:16180106 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [[[MPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of hydroquinone] which results in increased chemical synthesis of quinone] which results in decreased activity of PTPN2 protein; [[MPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of hydroquinone] which results in increased chemical synthesis of quinone CTD PMID:31248982 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mt1 metallothionein 1 increases expression ISO quinone results in increased expression of MT1 mRNA CTD PMID:14998373 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Myb MYB proto-oncogene, transcription factor increases activity
multiple interactions
ISO quinone results in increased activity of MYB protein
MYB protein promotes the reaction [quinone results in increased expression of TOP2A mRNA]
CTD PMID:18778717 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO NFE2L2 mRNA affects the reaction [quinone results in increased expression of GSS protein]; NFE2L2 mRNA affects the reaction [quinone results in increased expression of HMOX1 protein]; quinone affects the localization of and results in increased degradation of NFE2L2 protein; quinone inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of NFE2L2 protein]; quinone results in increased expression of and affects the localization of NFE2L2 protein
quinone results in increased expression of and affects the localization of and results in increased activity of NFE2L2 protein
CTD PMID:21059386, PMID:25437431, PMID:28645578 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions
increases expression
ISO [quinone results in increased expression of NOX1 protein] which results in increased abundance of Reactive Oxygen Species CTD PMID:25437431 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Nox4 NADPH oxidase 4 decreases expression ISO quinone results in decreased expression of NOX4 protein CTD PMID:30448556 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO quinone results in increased expression of NQO1 protein
quinone results in increased expression of NQO1 mRNA; quinone results in increased expression of NQO1 protein
CTD PMID:8652659, PMID:20491607, PMID:21059386, PMID:25437431, PMID:28645578 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase decreases expression ISO quinone results in decreased expression of OGG1 mRNA CTD PMID:26456483 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions ISO [HIF1A protein co-treated with quinone] results in increased expression of PDK1 protein CTD PMID:30448556 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 increases expression
multiple interactions
ISO quinone results in increased expression of PFKFB3 protein
[HIF1A protein co-treated with quinone] results in increased expression of PFKFB3 protein
CTD PMID:30448556 NCBI chr17:70,632,778...70,713,736
Ensembl chr17:70,684,134...70,713,726
JBrowse link
G Pfkl phosphofructokinase, liver type increases expression
multiple interactions
ISO quinone results in increased expression of PFKL protein
[HIF1A protein co-treated with quinone] results in increased expression of PFKL protein
CTD PMID:30448556 NCBI chr20:11,393,860...11,415,889
Ensembl chr20:11,393,877...11,415,882
JBrowse link
G Pgk1 phosphoglycerate kinase 1 increases expression
multiple interactions
ISO quinone results in increased expression of PGK1 protein
[HIF1A protein co-treated with quinone] results in increased expression of PGK1 protein
CTD PMID:30448556 NCBI chr  X:77,263,399...77,279,373
Ensembl chr  X:77,263,359...77,279,367
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [quinone results in increased expression of PINK1 protein]; Cyclosporine inhibits the reaction [quinone results in increased expression of PINK1 mRNA]; Cyclosporine inhibits the reaction [quinone results in increased expression of PINK1 protein]
quinone results in increased expression of PINK1 mRNA; quinone results in increased expression of PINK1 protein
CTD PMID:29567065 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [quinone results in increased degradation of PKM protein]; quinone results in increased degradation of and results in decreased expression of PKM protein; Reactive Oxygen Species affects the reaction [quinone results in increased degradation of PKM protein]
quinone results in increased expression of PKM protein
[HIF1A protein co-treated with quinone] results in increased expression of PKM protein
CTD PMID:25437431, PMID:30448556 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Prkcb protein kinase C, beta increases expression ISO quinone results in increased expression of PRKCB protein CTD PMID:31958493 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase increases expression
multiple interactions
ISO quinone results in increased expression of PRKN mRNA; quinone results in increased expression of PRKN protein
Acetylcysteine inhibits the reaction [quinone results in increased expression of PRKN protein]; Cyclosporine inhibits the reaction [quinone results in increased expression of PRKN mRNA]; Cyclosporine inhibits the reaction [quinone results in increased expression of PRKN protein]
CTD PMID:29567065 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 multiple interactions ISO [[[MPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of hydroquinone] which results in increased chemical synthesis of quinone] which results in decreased activity of PTPN2 protein; Glutathione inhibits the reaction [quinone results in decreased activity of PTPN2 protein]; quinone binds to and results in decreased activity of PTPN2 protein; Vanadates inhibits the reaction [quinone results in decreased activity of PTPN2 protein] CTD PMID:31248982 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression ISO quinone results in increased expression of RUNX2 mRNA CTD PMID:22960397 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO [HIF1A protein co-treated with quinone] results in increased expression of SLC2A1 protein CTD PMID:30448556 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO quinone results in increased expression of SOD1 protein CTD PMID:25437431 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO quinone results in increased expression of SOD2 protein CTD PMID:25437431 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sqstm1 sequestosome 1 decreases expression
multiple interactions
ISO quinone results in decreased expression of SQSTM1 protein
Cyclosporine inhibits the reaction [quinone results in decreased expression of SQSTM1 protein]
CTD PMID:29567065 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO quinone promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein] CTD PMID:31248982 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO quinone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:21235518 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Top2a DNA topoisomerase II alpha affects activity
decreases activity
increases expression
multiple interactions
increases activity
ISO quinone metabolite affects the activity of TOP2A protein
quinone results in decreased activity of TOP2A protein
quinone results in increased expression of TOP2A mRNA
MYB protein promotes the reaction [quinone results in increased expression of TOP2A mRNA]; quinone binds to and affects the activity of TOP2A protein; quinone binds to and results in decreased activity of TOP2A protein
quinone results in increased activity of TOP2A protein
CTD PMID:7586126, PMID:9118903, PMID:9118913, PMID:11468185, PMID:15833037, PMID:15935817, PMID:16906772, PMID:18778717, PMID:20034485, PMID:22218491, PMID:31340051 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tp53 tumor protein p53 increases expression ISO quinone results in increased expression of TP53 protein CTD PMID:20499891 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Wnt5a Wnt family member 5A increases expression ISO quinone results in increased expression of WNT5A mRNA CTD PMID:22960397 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860
JBrowse link
N-acetyl-1,4-benzoquinone imine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions
ISO N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 mRNA; N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 protein
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 protein]
CTD PMID:28286204, PMID:29355602 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Adarb2 adenosine deaminase, RNA-specific, B2 affects response to substance ISO ADARB2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr17:58,098,979...58,653,137
Ensembl chr17:58,104,559...58,301,260
JBrowse link
G Alcam activated leukocyte cell adhesion molecule affects response to substance ISO ALCAM gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr11:50,780,735...50,985,083
Ensembl chr11:50,781,127...50,985,083
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 affects response to substance ISO ALDH1A3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:127,302,920...127,337,828
Ensembl chr 1:127,301,128...127,337,882
JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of BMP2 mRNA CTD PMID:28286204 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Bpnt2 3'(2'), 5'-bisphosphate nucleotidase 2 affects response to substance ISO BPNT2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr17:90,191,119...90,218,013
Ensembl chr17:90,188,043...90,218,013
Ensembl chr 5:90,188,043...90,218,013
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H affects response to substance ISO CACNA1H gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617
JBrowse link
G Cald1 caldesmon 1 affects response to substance ISO CALD1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 4:62,103,948...62,291,375
Ensembl chr 4:62,220,736...62,291,489
JBrowse link
G Ccdc25 coiled-coil domain containing 25 affects response to substance ISO CCDC25 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr15:42,522,108...42,555,318
Ensembl chr15:42,522,108...42,553,398
JBrowse link
G Cd9 CD9 molecule affects response to substance ISO CD9 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 4:157,977,163...158,010,091
Ensembl chr 4:157,977,162...158,010,166
JBrowse link
G Cep44 centrosomal protein 44 affects response to substance ISO CEP44 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr16:37,177,379...37,199,043
Ensembl chr16:37,177,443...37,196,784
JBrowse link
G Cnr1 cannabinoid receptor 1 affects response to substance ISO CNR1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression
multiple interactions
ISO N-acetyl-4-benzoquinoneimine results in increased expression of COL1A1 mRNA
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL1A1 mRNA]
CTD PMID:28286204, PMID:29355602 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of COL1A2 mRNA CTD PMID:28286204 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression
multiple interactions
ISO N-acetyl-4-benzoquinoneimine results in increased expression of COL3A1 mRNA
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL3A1 mRNA]
CTD PMID:28286204, PMID:29355602 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Cpa6 carboxypeptidase A6 affects response to substance ISO CPA6 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 5:8,215,443...8,574,655
Ensembl chr 5:8,459,660...8,574,655
JBrowse link
G Cst5 cystatin D affects response to substance ISO CST5 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:144,569,502...144,574,112
Ensembl chr 3:144,569,502...144,574,112
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases abundance
ISO CYP1A2 protein results in increased chemical synthesis of and results in increased abundance of N-acetyl-4-benzoquinoneimine
CYP1A2 protein results in increased abundance of N-acetyl-4-benzoquinoneimine
CTD PMID:19679878, PMID:24661219 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases abundance ISO CYP2D6 protein results in increased abundance of N-acetyl-4-benzoquinoneimine CTD PMID:24661219 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases abundance
increases chemical synthesis
ISO
EXP
CYP2E1 protein results in increased chemical synthesis of and results in increased abundance of N-acetyl-4-benzoquinoneimine
CYP2E1 protein results in increased abundance of N-acetyl-4-benzoquinoneimine
CYP2E1 results in increased chemical synthesis of N-acetyl-4-benzoquinoneimine
CTD PMID:19679878, PMID:20566340, PMID:24661219 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Dmrt1 doublesex and mab-3 related transcription factor 1 affects response to substance ISO DMRT1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:243,477,403...243,582,629
Ensembl chr 1:243,477,493...243,582,629
JBrowse link
G Dnttip1 deoxynucleotidyltransferase, terminal, interacting protein 1 affects response to substance ISO DNTTIP1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:161,212,156...161,235,749
Ensembl chr 3:161,212,156...161,236,121
JBrowse link
G Dsc3 desmocollin 3 affects response to substance ISO DSC3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr18:11,753,047...11,789,846
Ensembl chr18:11,753,047...11,789,708
JBrowse link
G Etnk2 ethanolamine kinase 2 affects response to substance ISO ETNK2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr13:50,481,178...50,498,991
Ensembl chr13:50,481,163...50,499,140
JBrowse link
G Fbxo39 F-box protein 39 affects response to substance ISO FBXO39 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:58,874,028...58,878,445
Ensembl chr10:58,875,826...58,878,445
JBrowse link
G Frk fyn-related Src family tyrosine kinase affects response to substance ISO FRK gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr20:41,266,408...41,383,731
Ensembl chr20:41,266,566...41,383,424
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
affects response to substance
ISO [GPX1 protein co-treated with SOD1 protein] affects the susceptibility to N-acetyl-4-benzoquinoneimine
GPX1 protein affects the susceptibility to N-acetyl-4-benzoquinoneimine
CTD PMID:16636302 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects metabolic processing
multiple interactions
increases glutathionylation
increases metabolic processing
ISO
EXP
GSTP1 protein polymorphism affects the metabolism of N-acetyl-4-benzoquinoneimine metabolite
NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of N-acetyl-4-benzoquinoneimine]
GSTP1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine
CTD PMID:24185126, PMID:24552538 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hdac4 histone deacetylase 4 affects response to substance ISO HDAC4 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 9:99,052,945...99,299,715
Ensembl chr 9:99,057,089...99,299,715
JBrowse link
G Hid1 HID1 domain containing affects response to substance ISO HID1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:103,899,160...103,919,649
Ensembl chr10:103,899,150...103,919,605
JBrowse link
G Il23r interleukin 23 receptor affects response to substance ISO IL23R gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 4:98,203,788...98,306,729
Ensembl chr 4:98,203,958...98,305,173
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 affects response to substance ISO KCNJ3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:41,019,898...41,181,070
Ensembl chr 3:41,019,898...41,181,070
JBrowse link
G Kcnu1 potassium calcium-activated channel subfamily U member 1 affects response to substance ISO KCNU1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr16:70,913,825...70,998,593
Ensembl chr16:70,913,817...70,998,575
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions
affects metabolic processing
ISO KEAP1 protein inhibits the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]
N-acetyl-4-benzoquinoneimine affects the metabolism of KEAP1 protein
CTD PMID:18785192, PMID:19246624 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Lama4 laminin subunit alpha 4 affects response to substance ISO LAMA4 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr20:44,060,715...44,201,966
Ensembl chr20:44,060,731...44,209,614
JBrowse link
G Lmx1a LIM homeobox transcription factor 1 alpha affects response to substance ISO LMX1A gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr13:85,916,753...86,061,534
Ensembl chr13:85,918,252...86,061,176
JBrowse link
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 affects response to substance ISO MAGI2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 4:10,995,241...12,472,423
Ensembl chr 4:10,995,234...11,610,518
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO N-acetyl-4-benzoquinoneimine results in increased phosphorylation of MAPK1 protein CTD PMID:28286204 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO N-acetyl-4-benzoquinoneimine results in increased phosphorylation of MAPK3 protein CTD PMID:28286204 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mctp1 multiple C2 and transmembrane domain containing 1 affects response to substance ISO MCTP1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 2:3,400,883...4,089,949
Ensembl chr 2:3,400,977...4,088,989
JBrowse link
G Mfsd4a major facilitator superfamily domain containing 4A affects response to substance ISO MFSD4A gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr13:48,807,720...48,848,997
Ensembl chr13:48,807,720...48,848,997
JBrowse link
G MGC95208 similar to 4930453N24Rik protein affects response to substance ISO C3ORF38 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr11:1,814,294...1,818,942
Ensembl chr11:1,814,294...1,819,094
JBrowse link
G Mir135a microRNA 135a affects response to substance ISO MIR135A2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 7:32,894,877...32,894,976
Ensembl chr 7:32,894,877...32,894,976
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of MMP2 mRNA CTD PMID:28286204 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mtus2 microtubule associated scaffold protein 2 affects response to substance ISO MTUS2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr12:8,111,655...8,491,553
Ensembl chr12:8,111,667...8,418,966
JBrowse link
G Neb nebulin affects response to substance ISO NEB gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:37,658,081...37,855,843
Ensembl chr 3:37,658,563...37,854,561
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization
multiple interactions
increases activity
ISO N-acetyl-4-benzoquinoneimine affects the localization of NFE2L2 protein
NFE2L2 protein affects the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]
N-acetyl-4-benzoquinoneimine results in increased activity of NFE2L2 protein
CTD PMID:18785192, PMID:19246624 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nhlrc3 NHL repeat containing 3 affects response to substance ISO NHLRC3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 2:142,672,188...142,686,593
Ensembl chr 2:142,674,345...142,686,577
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases reduction
increases metabolic processing
increases expression
ISO KEAP1 protein inhibits the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]; NFE2L2 protein affects the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]
NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of N-acetyl-4-benzoquinoneimine]
NQO1 protein results in increased reduction of N-acetyl-4-benzoquinoneimine
CTD PMID:17188792, PMID:18785192, PMID:19246624, PMID:24552538 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 multiple interactions ISO NQO2 protein results in increased reduction of and results in decreased glutathionylation of N-acetyl-4-benzoquinoneimine; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of N-acetyl-4-benzoquinoneimine] CTD PMID:29281794 NCBI chr17:32,131,847...32,158,559
Ensembl chr17:32,132,347...32,158,538
JBrowse link
G Pcbd2 pterin-4 alpha-carbinolamine dehydratase 2 affects response to substance ISO PCBD2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr17:8,929,675...8,980,712
Ensembl chr17:8,929,810...8,980,571
JBrowse link
G Pvt1 Pvt1 oncogene affects response to substance ISO PVT1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 7:102,648,394...102,871,316 JBrowse link
G Rab3il1 RAB3A interacting protein-like 1 affects response to substance ISO RAB3IL1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:226,077,182...226,084,830
Ensembl chr 1:226,077,120...226,084,830
JBrowse link
G Rap1gap2 RAP1 GTPase activating protein 2 affects response to substance ISO RAP1GAP2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:61,177,936...61,395,856
Ensembl chr10:61,177,936...61,361,250
JBrowse link
G Slc39a11 solute carrier family 39, member 11 affects response to substance ISO SLC39A11 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:101,754,842...102,169,100
Ensembl chr10:101,754,830...102,084,035
JBrowse link
G Slit2 slit guidance ligand 2 affects response to substance ISO SLIT2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr14:66,831,848...67,171,491
Ensembl chr14:66,831,848...67,170,361
JBrowse link
G Snx16 sorting nexin 16 affects response to substance ISO SNX16 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 2:93,518,796...93,541,056
Ensembl chr 2:93,518,806...93,540,328
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [GPX1 protein co-treated with SOD1 protein] affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:16636302 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Spag16 sperm associated antigen 16 affects response to substance ISO SPAG16 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 9:77,027,626...77,833,476
Ensembl chr 9:77,320,726...77,833,281
JBrowse link
G Stab1 stabilin 1 affects response to substance ISO STAB1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr16:7,220,434...7,250,934
Ensembl chr16:7,222,067...7,250,924
JBrowse link
G Syne3 spectrin repeat containing, nuclear envelope family member 3 affects response to substance ISO SYNE3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 6:128,639,036...128,716,061
Ensembl chr 6:128,641,214...128,727,374
JBrowse link
G Tac1 tachykinin, precursor 1 increases secretion EXP N-acetyl-4-benzoquinoneimine results in increased secretion of TAC1 protein CTD PMID:20720158 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of TGFB1 mRNA CTD PMID:28286204 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of TIMP1 mRNA CTD PMID:28286204 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tmprss2 transmembrane serine protease 2 affects response to substance ISO TMPRSS2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr11:38,063,914...38,103,406
Ensembl chr11:38,063,915...38,103,290
JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO N-acetyl-4-benzoquinoneimine results in decreased activity of TOP2A protein CTD PMID:15035644 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tpd52l1 TPD52 like 1 affects response to substance ISO TPD52L1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:28,454,949...28,578,736
Ensembl chr 1:28,454,966...28,576,553
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity
affects response to substance
multiple interactions
ISO
EXP
N-acetyl-4-benzoquinoneimine results in increased activity of TRPA1 protein
TRPA1 affects the susceptibility to N-acetyl-4-benzoquinoneimine
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased activity of TRPA1 protein]
CTD PMID:20720158 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases activity
multiple interactions
EXP N-acetyl-4-benzoquinoneimine results in decreased activity of TXNRD1 protein
Glutathione inhibits the reaction [N-acetyl-4-benzoquinoneimine results in decreased activity of TXNRD1 protein]
CTD PMID:24661219 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ubash3a ubiquitin associated and SH3 domain containing, A affects response to substance ISO UBASH3A gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr20:9,941,102...9,986,012
Ensembl chr20:9,948,908...9,985,133
JBrowse link
G Ube2e2 ubiquitin-conjugating enzyme E2E 2 affects response to substance ISO UBE2E2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr15:7,402,210...7,928,320
Ensembl chr15:7,871,497...7,927,939
JBrowse link
G Vwc2 von Willebrand factor C domain containing 2 affects response to substance ISO VWC2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr14:91,201,141...91,348,219
Ensembl chr14:91,201,730...91,348,219
JBrowse link
G Wfdc3 WAP four-disulfide core domain 3 affects response to substance ISO WFDC3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:161,193,904...161,212,063
Ensembl chr 3:161,193,769...161,212,188
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          cofactor 15531
            1,4-benzoquinone 144
              1,4-benzoquinone imine + 73
              2-prenyl-1,4-benzoquinone 0
              auricin 0
              quinhydrone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      ketone 16144
                                        cyclic ketone 13813
                                          quinone 8338
                                            benzoquinones 715
                                              1,4-benzoquinones 712
                                                1,4-benzoquinone 144
                                                  1,4-benzoquinone imine + 73
                                                  2-prenyl-1,4-benzoquinone 0
                                                  auricin 0
                                                  quinhydrone 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.