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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alanine
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Accession:CHEBI:16449 term browser browse the term
Definition:An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Synonyms:related_synonym: 2-Aminopropanoic acid;   2-Aminopropionic acid;   A;   ALA;   Alanin;   Formula=C3H7NO2;   InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6);   InChIKey=QNAYBMKLOCPYGJ-UHFFFAOYSA-N;   SMILES=CC(N)C(O)=O;   alanina
 alt_id: CHEBI:13748;   CHEBI:22277;   CHEBI:2539
 xref: Beilstein:635807;   CAS:302-72-7;   Drug_Central:4306;   Gmelin:2449;   KEGG:C01401;   PMID:17439666;   PMID:22264337;   Reaxys:635807;   Wikipedia:Alanine
 cyclic_relationship: is_conjugate_acid_of CHEBI:32439;   is_conjugate_base_of CHEBI:32440;   is_tautomer_of CHEBI:66916


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3-(5-fluorouracil-1-yl)-L-alanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GRIA3 glutamate ionotropic receptor AMPA type subunit 3 affects response to substance ISO GRIA3 protein affects the susceptibility to 5-fluorowillardiine CTD PMID:15264227 NCBI chr  X:123,184,278...123,490,915
Ensembl chr  X:123,184,153...123,490,915 		JBrowse link
3-cyanoalanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1H calcium voltage-gated channel subunit alpha1 H multiple interactions ISO 3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of CACNA1H protein] CTD PMID:29129814 NCBI chr16:1,153,106...1,221,768
Ensembl chr16:1,153,103...1,224,169 		JBrowse link
G EGR1 early growth response 1 multiple interactions ISO 3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of EGR1 protein] CTD PMID:29129814 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303 		JBrowse link
G USP5 ubiquitin specific peptidase 5 multiple interactions ISO 3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of USP5 protein] CTD PMID:29129814 NCBI chr12:6,852,150...6,866,632
Ensembl chr12:6,852,148...6,866,632 		JBrowse link
alliin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTSD cathepsin D multiple interactions ISO alliin affects the reaction [Isoproterenol affects the activity of CTSD protein] CTD PMID:17623887 NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,752...1,764,573 		JBrowse link
G FASN fatty acid synthase multiple interactions EXP alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of FASN mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of FASN protein] CTD PMID:29305303 NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294 		JBrowse link
G FGF2 fibroblast growth factor 2 decreases secretion
multiple interactions		 EXP alliin results in decreased secretion of FGF2 protein
alliin promotes the reaction [FGF2 protein results in increased expression of TP53 protein]		 CTD PMID:16351512 NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO
EXP		 alliin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR protein]		 CTD PMID:16640830 PMID:29305303 NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001 		JBrowse link
G LCAT lecithin-cholesterol acyltransferase multiple interactions ISO alliin inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein] CTD PMID:16640830 NCBI chr16:67,939,750...67,944,120
Ensembl chr16:67,939,750...67,944,131 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions EXP alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 protein] CTD PMID:29305303 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002 		JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 multiple interactions EXP alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 protein] CTD PMID:29305303 NCBI chr22:41,833,105...41,907,305
Ensembl chr22:41,833,105...41,907,306 		JBrowse link
G TP53 tumor protein p53 multiple interactions EXP alliin promotes the reaction [FGF2 protein results in increased expression of TP53 protein] CTD PMID:16351512 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G VEGFA vascular endothelial growth factor A decreases secretion EXP alliin results in decreased secretion of VEGFA protein CTD PMID:16351512 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
alpha-(methylamino)isobutyric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DDIT3 DNA damage inducible transcript 3 multiple interactions ISO 2-(methylamino)isobutyric acid inhibits the reaction [arsenite results in increased expression of DDIT3 mRNA] CTD PMID:22215663 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO 2-(methylamino)isobutyric acid inhibits the reaction [arsenite results in increased expression of HSPA5 mRNA] CTD PMID:22215663 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
G IGF1 insulin like growth factor 1 increases uptake
multiple interactions		 ISO IGF1 protein results in increased uptake of 2-(methylamino)isobutyric acid
oxophenylarsine inhibits the reaction [IGF1 protein results in increased uptake of 2-(methylamino)isobutyric acid]		 CTD PMID:1928324 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G INS-IGF2 INS-IGF2 readthrough increases transport
increases uptake
multiple interactions		 ISO INS1 protein results in increased transport of 2-(methylamino)isobutyric acid
INS1 protein results in increased uptake of 2-(methylamino)isobutyric acid
Wortmannin inhibits the reaction [INS1 protein results in increased uptake of 2-(methylamino)isobutyric acid]		 CTD PMID:1847587 PMID:9877156 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209 		JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 multiple interactions EXP 2-(methylamino)isobutyric acid inhibits the reaction [arsenite results in increased phosphorylation of RPS6KB1 protein] CTD PMID:22215663 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574 		JBrowse link
G SLC38A2 solute carrier family 38 member 2 multiple interactions ISO SLC38A2 mutant form inhibits the reaction [arsenite results in increased transport of 2-(methylamino)isobutyric acid] CTD PMID:22215663 NCBI chr12:46,358,188...46,372,773
Ensembl chr12:46,358,188...46,372,773 		JBrowse link
L-alanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DEK DEK proto-oncogene multiple interactions EXP DEK protein results in increased chemical synthesis of and results in increased secretion of Alanine CTD PMID:28558019 NCBI chr 6:18,223,860...18,264,530
Ensembl chr 6:18,223,860...18,264,548 		JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 decreases abundance
multiple interactions		 ISO IDH2 protein mutant form results in decreased abundance of Alanine
Triazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of Alanine]		 CTD PMID:27469509 NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,477 		JBrowse link
L-selenocysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALAD aminolevulinate dehydratase decreases activity ISO Selenocysteine analog results in decreased activity of ALAD protein CTD PMID:14630126 NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Selenocysteine inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]; Selenocysteine inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]; Selenocysteine inhibits the reaction [Peroxynitrous Acid results in increased expression of CXCL8 mRNA]; Selenocysteine inhibits the reaction [Peroxynitrous Acid results in increased expression of CXCL8 protein] CTD PMID:14572605 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Selenocysteine inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of FOS protein]; Selenocysteine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein] CTD PMID:14572605 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G GSTA2 glutathione S-transferase alpha 2 increases expression ISO Selenocysteine results in increased expression of GSTA2 mRNA CTD PMID:12034368 NCBI chr 6:52,750,087...52,763,475
Ensembl chr 6:52,750,087...52,763,475 		JBrowse link
G GSTA5 glutathione S-transferase alpha 5 increases expression ISO Selenocysteine results in increased expression of GSTA5 mRNA CTD PMID:12034368 NCBI chr 6:52,831,692...52,846,245
Ensembl chr 6:52,831,655...52,840,843 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 increases expression ISO Selenocysteine results in increased expression of GSTP1 mRNA CTD PMID:12034368 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP Selenocysteine inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of RELA protein]; Selenocysteine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein] CTD PMID:14572605 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
lanthionine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KYAT1 kynurenine aminotransferase 1 increases amination EXP KYAT1 protein results in increased amination of lanthionine CTD PMID:22093698 NCBI chr 9:128,832,942...128,882,523
Ensembl chr 9:128,832,942...128,882,494
Ensembl chr 9:128,832,942...128,882,494 		JBrowse link
LCL161 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP LCL161 binds to and affects the activity of ABCB1 protein; LCL161 inhibits the reaction [ABCB1 protein results in increased export of Fluorescent Dyes]; LCL161 inhibits the reaction [ABCB1 protein results in increased export of mitotracker green FM] CTD PMID:32497533 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 decreases expression
decreases expression 		EXP LCL161 results in decreased expression of BIRC2 protein
LCL161 decreases expression of BIRC2 protein in hepatocellular carcinoma cells		 CTD
RGD		 PMID:32497533 PMID:24976294 RGD:153305953 NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670 		JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 decreases expression EXP LCL161 decreases expression of BIRC3 protein in hepatocellular carcinoma cells RGD PMID:24976294 RGD:153305953 NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403 		JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 decreases expression EXP LCL161 results in decreased expression of BIRC5 protein CTD PMID:32497533 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636 		JBrowse link
G XIAP X-linked inhibitor of apoptosis decreases expression EXP LCL161 decreases expression of XIAP protein in hepatocellular carcinoma cells RGD PMID:24976294 RGD:153305953 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,712...123,913,972 		JBrowse link
metalaxyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases expression EXP metalaxyl results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 decreases expression EXP metalaxyl results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163 		JBrowse link
G S100P S100 calcium binding protein P increases expression EXP metalaxyl results in increased expression of S100P protein CTD PMID:32194361 NCBI chr 4:6,693,878...6,697,170
Ensembl chr 4:6,693,878...6,697,170 		JBrowse link
N-benzoyl-L-alanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NCOA2 nuclear receptor coactivator 2 multiple interactions EXP N-benzoylalanine promotes the reaction [THRA protein binds to NCOA2 protein]; N-benzoylalanine promotes the reaction [THRB protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr 8:70,109,782...70,456,446
Ensembl chr 8:70,109,782...70,403,808 		JBrowse link
G THRA thyroid hormone receptor alpha multiple interactions EXP N-benzoylalanine promotes the reaction [THRA protein binds to NCOA2 protein] CTD PMID:31566444 NCBI chr17:40,062,193...40,093,867
Ensembl chr17:40,058,290...40,093,867 		JBrowse link
G THRB thyroid hormone receptor beta multiple interactions
affects binding		 EXP N-benzoylalanine promotes the reaction [THRB protein binds to NCOA2 protein]
N-benzoylalanine binds to THRB protein		 CTD PMID:31566444 NCBI chr 3:24,117,153...24,495,708
Ensembl chr 3:24,117,153...24,495,756 		JBrowse link
Se-methyl-L-selenocysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) multiple interactions EXP [selenomethylselenocysteine co-treated with irinotecan] results in decreased expression of ABCC1 CTD PMID:15897249 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257 		JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 (PEL blood group) multiple interactions
decreases expression		 ISO Isoflavones promotes the reaction [selenomethylselenocysteine results in decreased expression of ABCC4 mRNA] CTD PMID:19025659 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475 		JBrowse link
G APAF1 apoptotic peptidase activating factor 1 increases expression EXP selenomethylselenocysteine metabolite results in increased expression of APAF1 mRNA CTD PMID:25321483 NCBI chr12:98,645,290...98,735,433
Ensembl chr12:98,645,290...98,735,433 		JBrowse link
G AR androgen receptor decreases expression ISO selenomethylselenocysteine results in decreased expression of AR protein
selenomethylselenocysteine results in decreased expression of AR mRNA		 CTD PMID:16637076 PMID:19025659 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G BAK1 BCL2 antagonist/killer 1 increases expression EXP selenomethylselenocysteine metabolite results in increased expression of BAK1 mRNA CTD PMID:25321483 NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293 		JBrowse link
G BANP BTG3 associated nuclear protein increases expression EXP selenomethylselenocysteine results in increased expression of BANP mRNA CTD PMID:18514395 NCBI chr16:87,949,238...88,077,318
Ensembl chr16:87,949,244...88,077,318 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions		 EXP
ISO		 selenomethylselenocysteine results in decreased expression of BCL2 mRNA
selenomethylselenocysteine results in decreased expression of BCL2 protein
[selenomethylselenocysteine results in decreased expression of BCL2 mRNA] which results in increased activity of TNFSF10 protein		 CTD PMID:11396176 PMID:19360359 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2L1 BCL2 like 1 decreases expression EXP selenomethylselenocysteine metabolite results in decreased expression of BCL2L1 mRNA CTD PMID:25321483 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G BCL2L11 BCL2 like 11 increases expression EXP selenomethylselenocysteine metabolite results in increased expression of BCL2L11 mRNA CTD PMID:25321483 NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,444 		JBrowse link
G BMAL1 basic helix-loop-helix ARNT like 1 decreases expression ISO selenomethylselenocysteine results in decreased expression of BMAL1 mRNA CTD PMID:19122877 NCBI chr11:13,276,652...13,387,266
Ensembl chr11:13,276,652...13,387,266 		JBrowse link
G BMF Bcl2 modifying factor multiple interactions
increases expression		 EXP
ISO		 4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP3 protein modified form]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP6 protein modified form]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP9 protein modified form]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of PARP1 protein modified form]; HDAC8 inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]; selenomethylselenocysteine metabolite inhibits the reaction [HDAC8 protein binds to BMF promoter]; selenomethylselenocysteine metabolite inhibits the reaction [STAT3 protein binds to BMF promoter]; selenomethylselenocysteine metabolite promotes the reaction [EP300 protein binds to BMF promoter]; selenomethylselenocysteine metabolite promotes the reaction [SP3 protein binds to BMF promoter]; STAT3 protein inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]
selenomethylselenocysteine metabolite results in increased expression of BMF protein
selenomethylselenocysteine metabolite results in increased expression of BMF mRNA; selenomethylselenocysteine metabolite results in increased expression of BMF protein		 CTD PMID:25321483 NCBI chr15:40,087,890...40,108,879
Ensembl chr15:40,087,890...40,108,892 		JBrowse link
G CASP3 caspase 3 increases activity
increases expression
multiple interactions		 ISO
EXP		 selenomethylselenocysteine results in increased activity of CASP3 protein
selenomethylselenocysteine metabolite results in increased expression of CASP3 protein modified form
BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP3 protein modified form]		 CTD PMID:15318939 PMID:25321483 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP6 caspase 6 increases expression
multiple interactions		 EXP selenomethylselenocysteine metabolite results in increased expression of CASP6 protein modified form
BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP6 protein modified form]		 CTD PMID:25321483 NCBI chr 4:109,664,388...109,709,767
Ensembl chr 4:109,688,622...109,703,583 		JBrowse link
G CASP8 caspase 8 increases expression EXP selenomethylselenocysteine metabolite results in increased expression of CASP8 protein modified form CTD PMID:25321483 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 multiple interactions
increases expression		 EXP BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP9 protein modified form] CTD PMID:25321483 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CCNA2 cyclin A2 decreases expression ISO selenomethylselenocysteine results in decreased expression of CCNA2 protein CTD PMID:11396176 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883 		JBrowse link
G CCND1 cyclin D1 decreases expression
multiple interactions		 EXP
ISO		 selenomethylselenocysteine results in decreased expression of CCND1 protein
selenomethylselenocysteine results in decreased expression of CCND1 mRNA; selenomethylselenocysteine results in decreased expression of CCND1 protein
[selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of CCND1 protein		 CTD PMID:11396176 PMID:18855134 PMID:19276161 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CDK2 cyclin dependent kinase 2 multiple interactions ISO selenomethylselenocysteine results in decreased phosphorylation of and results in decreased activity of CDK2 protein CTD PMID:10656618 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression
multiple interactions		 EXP selenomethylselenocysteine metabolite results in increased expression of CDKN1A protein
[Aminooxyacetic Acid results in decreased metabolism of selenomethylselenocysteine] which results in decreased expression of CDKN1A protein		 CTD PMID:25321483 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B increases expression ISO selenomethylselenocysteine results in increased expression of CDKN1B protein CTD PMID:11396176 PMID:19276161 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369 		JBrowse link
G CES1 carboxylesterase 1 increases expression EXP selenomethylselenocysteine results in increased expression of CES1 CTD PMID:15897249 NCBI chr16:55,802,851...55,833,096
Ensembl chr16:55,802,851...55,833,337 		JBrowse link
G CHMP1A charged multivesicular body protein 1A increases expression EXP selenomethylselenocysteine results in increased expression of CHMP1A mRNA CTD PMID:18514395 NCBI chr16:89,644,435...89,657,708
Ensembl chr16:89,640,816...89,657,738 		JBrowse link
G COL1A1 collagen type I alpha 1 chain decreases expression EXP selenomethylselenocysteine results in decreased expression of COL1A1 mRNA; selenomethylselenocysteine results in decreased expression of COL1A1 protein CTD PMID:18514395 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G COL1A2 collagen type I alpha 2 chain decreases expression EXP selenomethylselenocysteine results in decreased expression of COL1A2 mRNA; selenomethylselenocysteine results in decreased expression of COL1A2 protein CTD PMID:18514395 NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227 		JBrowse link
G COL4A5 collagen type IV alpha 5 chain increases expression EXP selenomethylselenocysteine results in increased expression of COL4A5 mRNA CTD PMID:18514395 NCBI chr  X:108,439,838...108,697,545
Ensembl chr  X:108,439,838...108,697,545 		JBrowse link
G COL6A1 collagen type VI alpha 1 chain increases expression EXP selenomethylselenocysteine results in increased expression of COL6A1 mRNA CTD PMID:18514395 NCBI chr21:45,981,770...46,005,048
Ensembl chr21:45,981,770...46,005,050 		JBrowse link
G COL7A1 collagen type VII alpha 1 chain decreases expression EXP selenomethylselenocysteine results in decreased expression of COL7A1 mRNA CTD PMID:18514395 NCBI chr 3:48,564,073...48,595,329
Ensembl chr 3:48,564,073...48,595,329 		JBrowse link
G CRY2 cryptochrome circadian regulator 2 increases expression ISO selenomethylselenocysteine results in increased expression of CRY2 mRNA CTD PMID:19122877 NCBI chr11:45,847,118...45,883,244
Ensembl chr11:45,847,118...45,883,248 		JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 multiple interactions EXP [selenomethylselenocysteine co-treated with irinotecan] results in increased expression of CYP3A5 CTD PMID:15897249 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996 		JBrowse link
G DBP D-box binding PAR bZIP transcription factor increases expression ISO selenomethylselenocysteine results in increased expression of DBP mRNA CTD PMID:19122877 NCBI chr19:48,630,030...48,637,379
Ensembl chr19:48,630,030...48,637,379 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression ISO selenomethylselenocysteine results in increased expression of DDIT3 mRNA CTD PMID:10656618 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737 		JBrowse link
G DHCR24 24-dehydrocholesterol reductase decreases expression ISO selenomethylselenocysteine results in decreased expression of DHCR24 mRNA CTD PMID:19025659 NCBI chr 1:54,849,627...54,887,195
Ensembl chr 1:54,849,627...54,887,195 		JBrowse link
G DRG1 developmentally regulated GTP binding protein 1 multiple interactions EXP [selenomethylselenocysteine co-treated with irinotecan] results in decreased expression of DRG1 CTD PMID:15897249 NCBI chr22:31,399,604...31,434,452
Ensembl chr22:31,399,604...31,530,634 		JBrowse link
G EP300 E1A binding protein p300 multiple interactions EXP selenomethylselenocysteine metabolite promotes the reaction [EP300 protein binds to BMF promoter] CTD PMID:25321483 NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,592...41,180,077 		JBrowse link
G ESR1 estrogen receptor 1 decreases expression
multiple interactions		 EXP selenomethylselenocysteine results in decreased expression of ESR1 protein
[selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of ESR1 protein		 CTD PMID:18855134 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G FASLG Fas ligand multiple interactions EXP [selenomethylselenocysteine co-treated with irinotecan] results in increased expression of FASLG CTD PMID:15897249 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha increases expression ISO selenomethylselenocysteine results in increased expression of GADD45A mRNA CTD PMID:10656618 NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334 		JBrowse link
G GPX1 glutathione peroxidase 1 increases activity
increases expression		 EXP selenomethylselenocysteine results in increased activity of GPX1 protein
selenomethylselenocysteine results in increased expression of GPX1 mRNA; selenomethylselenocysteine results in increased expression of GPX1 protein		 CTD PMID:18514395 PMID:19033020 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605 		JBrowse link
G GPX4 glutathione peroxidase 4 increases expression EXP selenomethylselenocysteine results in increased expression of GPX4 mRNA CTD PMID:18514395 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,982...1,106,791 		JBrowse link
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 increases expression EXP selenomethylselenocysteine results in increased expression of GRIK1 mRNA CTD PMID:18514395 NCBI chr21:29,536,933...29,939,996
Ensembl chr21:29,536,933...29,940,033 		JBrowse link
G GRIK3 glutamate ionotropic receptor kainate type subunit 3 increases expression EXP selenomethylselenocysteine results in increased expression of GRIK3 mRNA CTD PMID:18514395 NCBI chr 1:36,795,527...37,034,515
Ensembl chr 1:36,795,527...37,034,515 		JBrowse link
G HDAC8 histone deacetylase 8 multiple interactions EXP HDAC8 inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]; selenomethylselenocysteine metabolite inhibits the reaction [HDAC8 protein binds to BMF promoter] CTD PMID:25321483 NCBI chr  X:72,329,516...72,572,843
Ensembl chr  X:72,329,516...72,573,101 		JBrowse link
G IGF1R insulin like growth factor 1 receptor increases expression EXP selenomethylselenocysteine results in increased expression of IGF1R mRNA CTD PMID:18514395 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation ISO selenomethylselenocysteine results in increased phosphorylation of JUN protein CTD PMID:19276161 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G KLK1 kallikrein 1 decreases expression ISO selenomethylselenocysteine results in decreased expression of KLK3 protein CTD PMID:16637076 NCBI chr19:50,819,146...50,823,787
Ensembl chr19:50,819,146...50,823,787 		JBrowse link
G MKI67 marker of proliferation Ki-67 multiple interactions
decreases expression		 EXP [selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of MKI67 protein
selenomethylselenocysteine results in decreased expression of MKI67 protein		 CTD PMID:18855134 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423 		JBrowse link
G MSRB1 methionine sulfoxide reductase B1 increases expression EXP selenomethylselenocysteine results in increased expression of MSRB1 mRNA CTD PMID:18514395 NCBI chr16:1,938,229...1,943,199
Ensembl chr16:1,938,229...1,943,199 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein] CTD PMID:21213327 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:21213327 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G P4HA1 prolyl 4-hydroxylase subunit alpha 1 increases expression EXP selenomethylselenocysteine results in increased expression of P4HA1 mRNA CTD PMID:18514395 NCBI chr10:73,007,217...73,096,866
Ensembl chr10:73,007,217...73,096,974 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions
increases expression		 EXP [Aminooxyacetic Acid results in decreased metabolism of selenomethylselenocysteine] which results in decreased expression of PARP1 protein modified form; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of PARP1 protein modified form] CTD PMID:25321483 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PER2 period circadian regulator 2 increases expression ISO selenomethylselenocysteine results in increased expression of PER2 mRNA CTD PMID:19122877 NCBI chr 2:238,244,044...238,300,065
Ensembl chr 2:238,244,044...238,290,102 		JBrowse link
G PER3 period circadian regulator 3 increases expression ISO selenomethylselenocysteine results in increased expression of PER3 mRNA CTD PMID:19122877 NCBI chr 1:7,784,291...7,845,177
Ensembl chr 1:7,784,291...7,845,177 		JBrowse link
G PGR progesterone receptor decreases expression
multiple interactions		 EXP selenomethylselenocysteine results in decreased expression of PGR protein
[selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of PGR protein		 CTD PMID:18855134 NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813 		JBrowse link
G PPP1R15A protein phosphatase 1 regulatory subunit 15A increases expression ISO selenomethylselenocysteine results in increased expression of PPP1R15A mRNA CTD PMID:10656618 NCBI chr19:48,872,421...48,876,058
Ensembl chr19:48,872,212...48,876,059 		JBrowse link
G PRKCE protein kinase C epsilon decreases expression ISO selenomethylselenocysteine results in decreased expression of PRKCE protein CTD PMID:10656618 NCBI chr 2:45,651,279...46,187,990
Ensembl chr 2:45,651,345...46,187,990 		JBrowse link
G PRKCZ protein kinase C zeta decreases expression ISO selenomethylselenocysteine results in decreased expression of PRKCZ protein CTD PMID:10656618 NCBI chr 1:2,048,504...2,185,395
Ensembl chr 1:2,050,411...2,185,395 		JBrowse link
G RAB3B RAB3B, member RAS oncogene family increases expression EXP selenomethylselenocysteine results in increased expression of RAB3B mRNA CTD PMID:18514395 NCBI chr 1:51,907,956...51,990,700
Ensembl chr 1:51,907,956...51,990,700 		JBrowse link
G RAB4A RAB4A, member RAS oncogene family increases expression EXP selenomethylselenocysteine results in increased expression of RAB4A mRNA CTD PMID:18514395 NCBI chr 1:229,271,111...229,305,894
Ensembl chr 1:229,271,062...229,305,894 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein] CTD PMID:21213327 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G SCARB1 scavenger receptor class B member 1 increases expression EXP selenomethylselenocysteine results in increased expression of SCARB1 mRNA CTD PMID:18514395 NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668 		JBrowse link
G SELENOF selenoprotein F increases expression EXP selenomethylselenocysteine results in increased expression of SELENOF mRNA CTD PMID:18514395 NCBI chr 1:86,862,445...86,914,577
Ensembl chr 1:86,862,445...86,914,424 		JBrowse link
G SELENOP selenoprotein P increases expression EXP selenomethylselenocysteine results in increased expression of SELENOP mRNA CTD PMID:18514395 NCBI chr 5:42,799,880...42,811,892
Ensembl chr 5:42,799,880...42,887,392 		JBrowse link
G SELENOW selenoprotein W increases expression EXP selenomethylselenocysteine results in increased expression of SELENOW mRNA CTD PMID:18514395 NCBI chr19:47,778,703...47,784,682
Ensembl chr19:47,778,677...47,784,686 		JBrowse link
G SLC3A1 solute carrier family 3 member 1 increases uptake EXP SLC3A1 protein results in increased uptake of selenomethylselenocysteine CTD PMID:18845132 NCBI chr 2:44,275,480...44,322,437
Ensembl chr 2:44,275,458...44,321,494 		JBrowse link
G SLC6A19 solute carrier family 6 member 19 increases uptake ISO SLC6A19 protein results in increased uptake of selenomethylselenocysteine CTD PMID:18845132 NCBI chr 5:1,201,595...1,225,111
Ensembl chr 5:1,201,595...1,225,111 		JBrowse link
G SLC6A20 solute carrier family 6 member 20 increases uptake ISO SLC6A20B protein results in increased uptake of selenomethylselenocysteine CTD PMID:18845132 NCBI chr 3:45,755,449...45,796,536
Ensembl chr 3:45,755,449...45,796,574 		JBrowse link
G SNAP23 synaptosome associated protein 23 decreases expression EXP selenomethylselenocysteine results in decreased expression of SNAP23 mRNA CTD PMID:18514395 NCBI chr15:42,491,129...42,533,058
Ensembl chr15:42,491,233...42,545,356 		JBrowse link
G SORT1 sortilin 1 increases expression EXP selenomethylselenocysteine results in increased expression of SORT1 mRNA CTD PMID:18514395 NCBI chr 1:109,309,575...109,397,918
Ensembl chr 1:109,309,568...109,397,918 		JBrowse link
G SP3 Sp3 transcription factor multiple interactions EXP selenomethylselenocysteine metabolite promotes the reaction [SP3 protein binds to BMF promoter] CTD PMID:25321483 NCBI chr 2:173,900,775...173,965,702
Ensembl chr 2:173,880,850...173,965,373 		JBrowse link
G SPP1 secreted phosphoprotein 1 decreases expression ISO selenomethylselenocysteine results in decreased expression of SPP1 protein CTD PMID:15318939 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532 		JBrowse link
G SRD5A1 steroid 5 alpha-reductase 1 multiple interactions ISO [selenomethylselenocysteine co-treated with Isoflavones] results in decreased activity of SRD5A1 protein CTD PMID:19025659 NCBI chr 5:6,633,440...6,674,386
Ensembl chr 5:6,633,290...6,676,539 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions EXP selenomethylselenocysteine metabolite inhibits the reaction [STAT3 protein binds to BMF promoter]; STAT3 protein inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA] CTD PMID:25321483 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
G STX3 syntaxin 3 increases expression EXP selenomethylselenocysteine results in increased expression of STX3 mRNA CTD PMID:18514395 NCBI chr11:59,754,188...59,805,878
Ensembl chr11:59,713,456...59,805,882 		JBrowse link
G TNFSF10 TNF superfamily member 10 multiple interactions EXP [selenomethylselenocysteine results in decreased expression of BCL2 mRNA] which results in increased activity of TNFSF10 protein CTD PMID:19360359 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475 		JBrowse link
G TRNAU1AP tRNA selenocysteine 1 associated protein 1 increases expression EXP selenomethylselenocysteine results in increased expression of TRNAU1AP mRNA CTD PMID:18514395 NCBI chr 1:28,553,085...28,578,545
Ensembl chr 1:28,553,085...28,578,545 		JBrowse link
G XPA XPA, DNA damage recognition and repair factor multiple interactions EXP selenomethylselenocysteine inhibits the reaction [Zinc binds to XPA protein] CTD PMID:15265038 NCBI chr 9:97,654,398...97,697,340
Ensembl chr 9:97,674,909...97,697,340 		JBrowse link
sofosbuvir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KLRC1 killer cell lectin like receptor C1 decreases expression EXP sofosbuvir co-treated with ledipasvir decreases expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr12:10,442,264...10,454,685
Ensembl chr12:10,442,264...10,454,685 		JBrowse link
G NCR1 natural cytotoxicity triggering receptor 1 affects expression EXP sofosbuvir co-treated with ledipasvir affects expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr19:54,898,198...54,938,208
Ensembl chr19:54,906,148...54,916,140 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      biological role 25929
        biochemical role 25162
          metabolite 25092
            fundamental metabolite 15671
              alanine 116
                D-alanine + 3
                L-alanine + 107
                L-alanine-2,3,3,3-d4 0
                alanine derivative + 114
                alanine residue + 0
                alanine-2,3,3,3-d4 0
                alanine-d7 0
                alanino group + 0
                alanyl group + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      carbon group element atom 25434
                        carbon atom 25403
                          organic molecular entity 25392
                            heteroorganic entity 24766
                              organochalcogen compound 24378
                                organooxygen compound 24054
                                  carbon oxoacid 22749
                                    carboxylic acid 22729
                                      monocarboxylic acid 21724
                                        fatty acid 18997
                                          saturated fatty acid 18699
                                            propionic acid 4404
                                              alanine 116
                                                D-alanine + 3
                                                L-alanine + 107
                                                L-alanine-2,3,3,3-d4 0
                                                alanine derivative + 114
                                                alanine residue + 0
                                                alanine-2,3,3,3-d4 0
                                                alanine-d7 0
                                                alanino group + 0
                                                alanyl group + 0
paths to the root