trans-caffeic acid - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	trans-caffeic acid	go back to main search page
Accession:	CHEBI:16433	browse the term
Definition:	The trans-isomer of caffeic acid.
Synonyms:	exact_synonym:	(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
	related_synonym:	3,4-Dihydroxy-trans-cinnamate; 3,4-Dihydroxycinnamic acid; Caffeic acid; Formula=C9H8O4; InChI=1S/C9H8O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1-5,10-11H,(H,12,13)/b4-2+; InChIKey=QAIPRVGONGVQAS-DUXPYHPUSA-N; SMILES=OC(=O)\\C=C\\c1ccc(O)c(O)c1; trans-Caffeate
	alt_id:	CHEBI:11691; CHEBI:11692; CHEBI:12870; CHEBI:1379; CHEBI:19877; CHEBI:41964
	xref:	Beilstein:1954563; CAS:331-39-5; CAS:501-16-6; HMDB:HMDB0001964; KEGG:C01197; KEGG:C01481; KNApSAcK:C00000615
	xref_mesh:	MESH:C040048
	xref:	PDBeChem:DHC; PMID:21503726; Reaxys:1954563; Wikipedia:Caffeic_acid
	cyclic_relationship:	is_conjugate_acid_of CHEBI:57770

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Genes (293)

trans-caffeic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA carboxylase alpha

multiple interactions

caffeic acid results in increased phosphorylation of and results in decreased activity of ACACA protein

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

acetylcholinesterase

multiple interactions
decreases activity

caffeic acid inhibits the reaction [Caffeine results in decreased activity of ACHE protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of ACHE protein]

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

ATP citrate lyase

multiple interactions

[Metformin co-treated with caffeic acid] results in decreased expression of ACLY protein

NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320

G

arachidonate 15-lipoxygenase

decreases activity
multiple interactions

caffeic acid results in decreased activity of ALOX15 protein
[caffeic acid results in decreased activity of ALOX15 protein] inhibits the reaction [vorinostat results in increased activity of CASP3 protein]; [caffeic acid results in decreased activity of ALOX15 protein] which results in decreased chemical synthesis of 13-hydroxy-9,11-octadecadienoic acid; [caffeic acid results in decreased activity of ALOX15 protein] which results in increased abundance of 13-hydroxy-9,11-octadecadienoic acid; caffeic acid inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased activity of ALOX15 protein]

PMID:10904086 PMID:11406566 PMID:15574791

NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874

G

arachidonate 5-lipoxygenase

multiple interactions

caffeic acid inhibits the reaction [aluminum chloride results in increased expression of ALOX5 mRNA]; caffeic acid inhibits the reaction [aluminum chloride results in increased expression of ALOX5 protein]
caffeic acid inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein]; caffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 mRNA]; caffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 protein]; caffeic acid inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein]

PMID:18482095 PMID:18951527 PMID:27368151

NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743

G

amyloid beta precursor protein

multiple interactions

caffeic acid inhibits the reaction [aluminum chloride results in increased expression of APP protein modified form]; caffeic acid inhibits the reaction [aluminum chloride results in increased expression of APP protein]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

arginase 1

decreases activity

caffeic acid results in decreased activity of ARG1 protein

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

ATPase H+ transporting V0 subunit D2

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of ATP6V0D2 mRNA]

NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354

G

caspase 3

multiple interactions

[caffeic acid results in decreased activity of ALOX15 protein] inhibits the reaction [vorinostat results in increased activity of CASP3 protein]
caffeic acid inhibits the reaction [Valproic Acid results in increased expression of CASP3 protein]

PMID:15574791 PMID:29968957

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions
increases activity

caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [CAT protein results in increased metabolism of Hydrogen Peroxide]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of CAT protein]
caffeic acid results in increased activity of CAT protein
caffeic acid inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; caffeic acid inhibits the reaction [Nickel results in decreased activity of CAT protein]

PMID:18405891 PMID:21640567 PMID:22036979 PMID:27378625

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions

[Resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL2 mRNA; caffeic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]

PMID:16806235 PMID:31306686

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL3 mRNA

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 4

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL4 mRNA

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine receptor 1

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR1 mRNA

NCBI chr 8:123,556,286...123,561,841

G

C-C motif chemokine receptor 2

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR2 mRNA

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

G

C-C motif chemokine receptor 4

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR4 mRNA

NCBI chr 8:114,176,291...114,182,033
Ensembl chr 8:114,176,974...114,178,056

G

Cd4 molecule

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CD4 mRNA

NCBI chr 4:157,668,878...157,695,366

G

Cd68 molecule

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CD68 mRNA

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

G

cell division cycle 20

multiple interactions

[Thapsigargin co-treated with caffeic acid] results in increased expression of CDC20 mRNA

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

G

cyclin dependent kinase 2

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of CDK2 mRNA]

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

choline O-acetyltransferase

multiple interactions

caffeic acid inhibits the reaction [aluminum chloride results in decreased expression of CHAT protein]

NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093

G

catechol-O-methyltransferase

increases methylation

COMT protein results in increased methylation of caffeic acid

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

corticotropin releasing hormone

multiple interactions

caffeic acid inhibits the reaction [Malathion results in decreased expression of CRH mRNA]

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

cardiotrophin 1

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of CTF1 mRNA]

NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335

G

cathepsin B

multiple interactions

caffeic acid inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cathepsin D

multiple interactions

caffeic acid inhibits the reaction [Isoproterenol affects the activity of CTSD protein]

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

C-X-C motif chemokine ligand 2

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of CXCL2 mRNA]

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

caffeic acid inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

death-associated protein

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of DAP mRNA]

NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752

G

DnaJ heat shock protein family (Hsp40) member B11

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of DNAJB11 mRNA]

NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407

G

dihydropyrimidinase-like 4

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of DPYSL4 mRNA]

NCBI chr 1:193,883,039...193,898,916
Ensembl chr 1:193,883,106...193,898,914

G

endothelin 1

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of EDN1 mRNA

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

early growth response 1

multiple interactions

caffeic acid affects the reaction [Acetaminophen results in increased expression of and affects the localization of EGR1 protein]; caffeic acid inhibits the reaction [Acetaminophen results in increased expression of EGR1 mRNA]

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

engulfment and cell motility 2

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of ELMO2 mRNA]

NCBI chr 3:154,023,661...154,061,259
Ensembl chr 3:154,023,661...154,061,185

G

Ets2 repressor factor

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of ERF mRNA]

NCBI chr 1:80,829,935...80,838,388
Ensembl chr 1:80,829,935...80,838,388

G

coagulation factor III, tissue factor

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased expression of F3 protein]

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

fatty acid synthase

decreases expression
multiple interactions

caffeic acid results in decreased expression of FASN mRNA
[Metformin co-treated with caffeic acid] results in decreased expression of FASN protein

PMID:21870829 PMID:28576465

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

fibronectin leucine rich transmembrane protein 2

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of FLRT2 mRNA]

NCBI chr 6:114,777,547...114,872,688
Ensembl chr 6:114,777,599...114,872,785

G

Fms related receptor tyrosine kinase 4

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of FLT4 mRNA]

NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770

G

glucose-6-phosphate dehydrogenase

decreases activity

caffeic acid results in decreased activity of G6PD protein

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

growth arrest and DNA-damage-inducible, alpha

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased expression of GADD45A mRNA]; caffeic acid inhibits the reaction [Acetaminophen results in increased expression of GADD45A protein]

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

galactosidase, beta 1

multiple interactions

caffeic acid inhibits the reaction [Isoproterenol affects the activity of GLB1 protein]

NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127

G

glutaminase

increases expression

caffeic acid results in increased expression of GLS protein

NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900

G

glutamic-oxaloacetic transaminase 1

multiple interactions

caffeic acid inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

multiple interactions

caffeic acid inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GPT protein]
caffeic acid inhibits the reaction [Acetaminophen results in increased activity of GPT protein]

PMID:15212457 PMID:27720869

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione-disulfide reductase

multiple interactions

caffeic acid inhibits the reaction [Cisplatin results in decreased activity of GSR protein]
caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [GSR protein results in increased oxidation of NADP]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of GSR protein]
caffeic acid promotes the reaction [Thapsigargin results in decreased expression of GSR mRNA]

PMID:19442820 PMID:21640567 PMID:22036979

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase mu 1

decreases activity

caffeic acid results in decreased activity of GSTM1 protein

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase mu 2

decreases activity

caffeic acid results in decreased activity of GSTM2 protein

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase pi 1

decreases activity

caffeic acid results in decreased activity of GSTP1 protein

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

glucuronidase, beta

multiple interactions

caffeic acid inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]

NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905

G

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

multiple interactions

caffeic acid inhibits the reaction [Cisplatin results in decreased activity of H6PD protein]

NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171

G

hepatitis A virus cellular receptor 2

multiple interactions

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of HAVCR2 mRNA

NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137

G

hes family bHLH transcription factor 1

multiple interactions

caffeic acid inhibits the reaction [Valproic Acid results in increased expression of HES1 mRNA]

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

G

holocarboxylase synthetase

decreases activity

caffeic acid results in decreased activity of HLCS protein

NCBI chr11:33,455,806...33,635,197
Ensembl chr11:33,455,809...33,624,222

G

3-hydroxy-3-methylglutaryl-CoA reductase

decreases expression

caffeic acid results in decreased expression of HMGCR mRNA

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

heat shock protein 90 beta family member 1

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of HSP90B1 mRNA]

NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788

G

heat shock protein family E (Hsp10) member 1

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of HSPE1 mRNA]

NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089

G

interferon gamma

increases expression
multiple interactions

caffeic acid results in increased expression of IFNG protein
caffeic acid inhibits the reaction [Valproic Acid results in increased expression of IFNG protein]

PMID:27378625 PMID:29968957

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 10

decreases expression

caffeic acid results in decreased expression of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased expression of IL1B protein]
caffeic acid inhibits the reaction [Aluminum results in increased expression of IL1B protein]

PMID:27368151 PMID:27720869

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

increases expression

caffeic acid results in increased expression of IL2 protein

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 21 receptor

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of IL21R mRNA]

NCBI chr 1:180,168,028...180,195,690
Ensembl chr 1:180,168,097...180,195,522

G

interleukin 4

decreases expression

caffeic acid results in decreased expression of IL4 protein

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

increases expression
multiple interactions

caffeic acid results in increased expression of IL6 mRNA
caffeic acid inhibits the reaction [Acetaminophen results in increased expression of IL6 protein]
caffeic acid inhibits the reaction [Aluminum results in increased expression of IL6 protein]

PMID:21870829 PMID:27368151 PMID:27720869

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

kinesin family member 15

multiple interactions

[Thapsigargin co-treated with caffeic acid] results in increased expression of KIF15 mRNA

NCBI chr 8:122,601,888...122,672,750
Ensembl chr 8:122,601,897...122,672,750

G

kinesin family member 20B

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of KIF20B mRNA]

NCBI chr 1:232,428,293...232,483,798
Ensembl chr 1:232,428,371...232,483,787

G

kinesin family member 2C

multiple interactions

caffeic acid inhibits the reaction [Thapsigargin results in increased expression of KIF2C mRNA]

NCBI chr 5:130,637,347...130,662,680
Ensembl chr 5:130,637,347...130,662,637

G

lactate dehydrogenase A

multiple interactions

caffeic acid inhibits the reaction [Isoproterenol results in increased expression of LDHA protein]

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

lactate dehydrogenase B

multiple interactions

caffeic acid inhibits the reaction [Isoproterenol results in increased expression of LDHB protein]

NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403

G

monoamine oxidase A

decreases activity

caffeic acid results in decreased activity of MAOA protein

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

monoamine oxidase B

decreases activity

caffeic acid results in decreased activity of MAOB protein

NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003

G

mitogen activated protein kinase kinase 5

multiple interactions

[Thapsigargin co-treated with caffeic acid] results in decreased expression of MAP2K5 mRNA

NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983

G

mitogen activated protein kinase 1

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitofusin 1

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MFN1 mRNA]

NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640

G

microsomal glutathione S-transferase 1

increases activity

caffeic acid results in increased activity of MGST1 protein

NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892

G

myeloperoxidase

multiple interactions
decreases activity

caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [MPO protein results in increased metabolism of Hydrogen Peroxide]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MPO protein]
caffeic acid inhibits the reaction [Ethanol results in increased activity of MPO protein]; NG-Nitroarginine Methyl Ester inhibits the reaction [caffeic acid inhibits the reaction [Ethanol results in increased activity of MPO protein]]
caffeic acid results in decreased activity of MPO protein

PMID:22036979 PMID:24060682 PMID:33301711

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mitochondrial ribosomal protein L45

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MRPL45 mRNA]

NCBI chr10:82,308,650...82,320,474
Ensembl chr10:82,308,427...82,320,474

G

mitochondrial ribosome recycling factor

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MRRF mRNA]

NCBI chr 3:19,487,124...19,543,911
Ensembl chr 3:19,487,182...19,543,908

G

mitochondrially encoded cytochrome c oxidase II

multiple interactions

[caffeic acid co-treated with Zymosan] results in increased expression of COX2 protein; caffeic acid inhibits the reaction [Zymosan results in increased expression of COX2 protein]

NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689

G

norrin cystine knot growth factor NDP

increases expression

caffeic acid results in increased expression of NDP mRNA

NCBI chr X:5,796,487...5,820,934
Ensembl chr X:5,796,487...5,820,934

G

nitric oxide synthase 2

multiple interactions

caffeic acid inhibits the reaction [Valproic Acid results in increased expression of NOS2 protein]
caffeic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

PMID:29968957 PMID:31306686

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

increases expression

caffeic acid results in increased expression of NOS3 mRNA

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

notch receptor 1

multiple interactions

caffeic acid inhibits the reaction [Valproic Acid results in increased expression of NOTCH1 mRNA]

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

5' nucleotidase, ecto

multiple interactions
decreases activity

caffeic acid inhibits the reaction [Caffeine results in decreased activity of NT5E protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of NT5E protein]

NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881

G

programmed cell death 10

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PDCD10 mRNA]

NCBI chr 2:160,303,465...160,346,086
Ensembl chr 2:160,303,449...160,346,018

G

phosphogluconate dehydrogenase

decreases activity

caffeic acid results in decreased activity of PGD protein

NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778

G

phosphoinositide-3-kinase regulatory subunit 1

increases expression

caffeic acid results in increased expression of PIK3R1 mRNA

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

polo-like kinase 1

multiple interactions

[Thapsigargin co-treated with caffeic acid] results in increased expression of PLK1 mRNA

NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400

G

polo-like kinase 4

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of PLK4 mRNA]

NCBI chr 2:123,802,527...123,820,942
Ensembl chr 2:123,802,512...123,820,942

G

peroxisome proliferator-activated receptor gamma

increases expression

caffeic acid results in increased expression of PPARG mRNA

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

peroxiredoxin 5

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PRDX5 mRNA]

NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268

G

prostaglandin-endoperoxide synthase 2

multiple interactions

caffeic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PTGS2 mRNA]

PMID:19442820 PMID:22036979 PMID:31306686

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

pentraxin 3

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PTX3 mRNA]

NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of RAF1 protein]

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

caffeic acid inhibits the reaction [Valproic Acid results in increased expression of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

stearoyl-CoA desaturase

multiple interactions

[Metformin co-treated with caffeic acid] results in decreased expression of SCD1 protein

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

serpin family E member 1

multiple interactions

caffeic acid inhibits the reaction [Acetaminophen results in increased expression of SERPINE1 protein]

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

sideroflexin 4

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of SFXN4 mRNA]

NCBI chr 1:259,976,480...259,998,778
Ensembl chr 1:259,976,481...259,998,754

G

solute carrier family 2 member 2

increases expression

caffeic acid results in increased expression of SLC2A2 mRNA

NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933

G

solute carrier family 2 member 4

increases expression

caffeic acid results in increased expression of SLC2A4 mRNA

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 5 member 1

increases expression

caffeic acid results in increased expression of SLC5A1 mRNA

NCBI chr14:77,553,990...77,618,589
Ensembl chr14:77,553,843...77,618,547

G

synuclein alpha

multiple interactions

caffeic acid inhibits the reaction [SNCA protein binds to SNCA protein]

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

sterol regulatory element binding transcription factor 1

multiple interactions

[Metformin co-treated with caffeic acid] results in decreased expression of SREBF1 protein

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

serine/threonine kinase 32A

multiple interactions

[Thapsigargin co-treated with caffeic acid] results in decreased expression of STK32A mRNA

NCBI chr18:35,258,865...35,374,985
Ensembl chr18:35,259,052...35,369,451

G

sulfotransferase family 1A member 1

increases sulfation

SULT1A1 protein results in increased sulfation of caffeic acid

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

sulfotransferase family 1C member 2A

increases sulfation

SULT1C2 protein results in increased sulfation of caffeic acid

NCBI chr 9:6,873,697...6,904,736
Ensembl chr 9:6,874,249...6,904,734

G

tumor necrosis factor

multiple interactions
increases expression

caffeic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]
caffeic acid inhibits the reaction [Aluminum results in increased expression of TNF protein]; caffeic acid inhibits the reaction [Valproic Acid results in increased expression of TNF protein]
caffeic acid results in increased expression of TNF mRNA

PMID:21870829 PMID:22036979 PMID:27368151 PMID:29968957 PMID:31306686

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

affects expression
multiple interactions

caffeic acid affects the expression of TP53 protein
caffeic acid promotes the reaction [Thapsigargin results in decreased expression of TP53 mRNA]

PMID:11522280 PMID:19442820

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tyrosinase

increases oxidation
multiple interactions

TYR protein results in increased oxidation of caffeic acid
[TYR protein results in increased oxidation of caffeic acid] which results in decreased abundance of Glutathione

NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207

G

ubiquitin-conjugating enzyme E2C

multiple interactions

caffeic acid promotes the reaction [Thapsigargin results in increased expression of UBE2C mRNA]

NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339

G

UDP glucuronosyltransferase family 1 member A1

decreases activity

caffeic acid results in decreased activity of UGT1A1 protein

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation
decreases activity

UGT1A3 protein results in increased glucuronidation of caffeic acid
caffeic acid results in decreased activity of UGT1A3 protein

PMID:15117964 PMID:35868516

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A6

decreases activity

caffeic acid results in decreased activity of UGT1A6 protein

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

decreases activity

caffeic acid results in decreased activity of UGT1A9 protein

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 2 family, polypeptide B1

decreases activity

caffeic acid results in decreased activity of UGT2B17 protein

NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986

G

UDP glucuronosyltransferase family 2 member B7

decreases activity

caffeic acid results in decreased activity of UGT2B7 protein

NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604

G

vascular endothelial growth factor A

decreases secretion

caffeic acid results in decreased secretion of VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

xanthine dehydrogenase

multiple interactions

caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein]

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

acteoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle

decreases expression

acteoside results in decreased expression of ACTA2 protein

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

advanced glycosylation end product-specific receptor

decreases expression

acteoside results in decreased expression of AGER protein

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

aryl hydrocarbon receptor

multiple interactions
decreases localization

acteoside promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased localization of AHR protein]
acteoside results in decreased localization of AHR protein

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aryl hydrocarbon receptor nuclear translocator

increases localization

acteoside results in increased localization of ARNT protein

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

C-C motif chemokine ligand 2

decreases expression
multiple interactions
decreases secretion

acteoside results in decreased expression of CCL2 mRNA
acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]
acteoside results in decreased secretion of CCL2 protein

PMID:21756928 PMID:21967610

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin D1

decreases expression

acteoside results in decreased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

decreases expression

acteoside results in decreased expression of CCND2 protein

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

cyclin D3

decreases expression

acteoside results in decreased expression of CCND3 protein

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

G

cyclin E1

decreases expression

acteoside results in decreased expression of CCNE1 protein

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cadherin 1

increases expression

acteoside results in increased expression of CDH1 protein

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cyclin dependent kinase 2

multiple interactions

acteoside results in decreased expression of and results in decreased activity of CDK2 protein

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 4

decreases activity
multiple interactions

acteoside results in decreased activity of CDK4 protein
acteoside promotes the reaction [CDKN1A protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK4 protein]

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 6

multiple interactions

acteoside promotes the reaction [CDKN1A protein binds to CDK6 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK6 protein]; acteoside results in decreased expression of and results in decreased activity of CDK6 protein

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions

acteoside results in increased expression of CDKN1A mRNA; acteoside results in increased expression of CDKN1A protein
acteoside promotes the reaction [CDKN1A protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1A protein binds to CDK6 protein]

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

increases expression
multiple interactions

acteoside results in increased expression of CDKN1B mRNA; acteoside results in increased expression of CDKN1B protein
acteoside promotes the reaction [CDKN1B protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK6 protein]

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

C-X-C motif chemokine ligand 10

decreases secretion
decreases expression
multiple interactions

acteoside results in decreased secretion of CXCL10 protein
acteoside results in decreased expression of CXCL10 mRNA
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [PD168393 results in increased secretion of CXCL10 protein]; acteoside promotes the reaction [leptomycin B results in decreased secretion of CXCL10 protein]

PMID:21756928 PMID:21967610

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

acteoside results in increased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

acteoside inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CYP2E1 protein]

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

E2F transcription factor 1

multiple interactions

[acteoside results in decreased phosphorylation of RB1 protein] promotes the reaction [RB1 protein binds to E2F1 protein]

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

epidermal growth factor receptor

decreases phosphorylation
multiple interactions

acteoside results in decreased phosphorylation of EGFR protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein modified form]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein]

PMID:21756928 PMID:21967610

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

high mobility group box 1

decreases expression

acteoside results in decreased expression of HMGB1 protein

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

intercellular adhesion molecule 1

decreases expression

acteoside results in decreased expression of ICAM1 mRNA

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon gamma

decreases expression
multiple interactions

acteoside results in decreased expression of IFNG mRNA
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]

PMID:21371465 PMID:21756928

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 6

multiple interactions
decreases expression

acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]
acteoside results in decreased expression of IL6 mRNA

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

integrin subunit beta 2

multiple interactions

acteoside inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]; acteoside inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB2 protein]

NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions
decreases phosphorylation

acteoside results in increased phosphorylation of MAPK1 protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]
acteoside results in decreased phosphorylation of MAPK1 protein

PMID:21756928 PMID:23527233

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

decreases phosphorylation
multiple interactions
increases phosphorylation

acteoside results in decreased phosphorylation of MAPK3 protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]
acteoside results in increased phosphorylation of MAPK3 protein

PMID:21756928 PMID:23527233

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

NADPH oxidase 1

decreases activity

acteoside results in decreased activity of NOX1 protein

NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236

G

prostaglandin D2 synthase

affects binding

acteoside binds to PTGDS protein

NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[acteoside co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

Rac family small GTPase 1

decreases expression

Verbascoside decreases expression of RAC1 mRNA in colon cancer cells

RGD

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

RB transcriptional corepressor 1

decreases phosphorylation
multiple interactions

acteoside results in decreased phosphorylation of RB1 protein
[acteoside results in decreased phosphorylation of RB1 protein] promotes the reaction [RB1 protein binds to E2F1 protein]

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RELA proto-oncogene, NF-kB subunit

increases phosphorylation
multiple interactions
decreases phosphorylation

acteoside results in increased phosphorylation of RELA protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]
acteoside results in decreased phosphorylation of RELA protein

PMID:21756928 PMID:23527233

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

SMAD family member 2

increases phosphorylation

acteoside results in increased phosphorylation of SMAD2 protein

NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323

G

SMAD family member 3

increases phosphorylation

acteoside results in increased phosphorylation of SMAD3 protein

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

SMAD family member 7

increases expression

acteoside results in increased expression of SMAD7 protein

NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765

G

snail family transcriptional repressor 1

decreases expression

acteoside results in decreased expression of SNAI1 protein

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

snail family transcriptional repressor 2

decreases expression

acteoside results in decreased expression of SNAI2 protein

NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200

G

superoxide dismutase 2

decreases expression

acteoside results in decreased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

transforming growth factor alpha

multiple interactions

[acteoside co-treated with TGFA protein] results in increased expression of CXCL8 mRNA; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein modified form]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein]

PMID:21756928 PMID:21967610

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

G

transforming growth factor, beta 1

increases expression

acteoside results in increased expression of TGFB1 mRNA

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta receptor 1

decreases expression

acteoside results in decreased expression of TGFBR1 protein

NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777

G

transforming growth factor, beta receptor 2

decreases expression

acteoside results in decreased expression of TGFBR2 protein

NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228

G

tumor necrosis factor

multiple interactions

acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

vascular cell adhesion molecule 1

decreases expression

acteoside results in decreased expression of VCAM1 mRNA

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

chlorogenic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

multiple interactions

Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of ABCC1 protein]

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

multiple interactions

Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of ABCC2 protein]

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

acetylcholinesterase

decreases activity

Chlorogenic Acid results in decreased activity of ACHE protein

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

ATP citrate lyase

increases expression

Chlorogenic Acid results in increased expression of ACLY mRNA

NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320

G

actin alpha 2, smooth muscle

multiple interactions

Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

AKT serine/threonine kinase 1

multiple interactions

Chlorogenic Acid inhibits the reaction [Rotenone results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

multiple interactions

Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein]
Chlorogenic Acid affects the reaction [2,2'-azobis(2-amidinopropane) results in increased degradation of ALB protein]

PMID:11322927 PMID:23146752

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aquaporin 1

increases expression

Chlorogenic Acid results in increased expression of AQP1 mRNA

NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690

G

aquaporin 3 (Gill blood group)

increases expression

Chlorogenic Acid results in increased expression of AQP3 mRNA

NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720

G

androgen receptor

decreases expression

Chlorogenic Acid results in decreased expression of AR mRNA

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

activating transcription factor 4

multiple interactions

Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of ATF4 protein]

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

activating transcription factor 6

multiple interactions

Chlorogenic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of ATF6 protein]; Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of ATF6 protein]

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

BMP and activin membrane-bound inhibitor

multiple interactions

Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of BAMBI mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of BAMBI protein]

NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

Chlorogenic Acid inhibits the reaction [Aluminum Chloride results in increased expression of BAX protein]; Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in increased expression of BAX mRNA]
Chlorogenic Acid results in increased expression of BAX mRNA; Chlorogenic Acid results in increased expression of BAX protein
Chlorogenic Acid inhibits the reaction [Methotrexate results in increased expression of BAX protein]

PMID:25043994 PMID:28479099 PMID:28623112 PMID:33058431 PMID:33242462

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

Chlorogenic Acid inhibits the reaction [Glucose results in decreased expression of BCL2 protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in decreased expression of BCL2 protein]
Chlorogenic Acid results in decreased expression of BCL2 mRNA; Chlorogenic Acid results in decreased expression of BCL2 protein
Chlorogenic Acid inhibits the reaction [Aluminum Chloride results in decreased expression of BCL2 protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased expression of BCL2 mRNA]

PMID:28479099 PMID:28623112 PMID:33058431 PMID:33242462 PMID:34801538

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

calnexin

multiple interactions

Chlorogenic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of CANX protein]; Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of CANX protein]

NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821

G

caspase 12

multiple interactions

Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of CASP12 protein]

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

multiple interactions
increases expression

Chlorogenic Acid inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in increased expression of CASP3 mRNA]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]
Chlorogenic Acid results in increased expression of CASP3 mRNA
Chlorogenic Acid inhibits the reaction [Glucose results in increased activity of CASP3 protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in increased activity of CASP3 protein]

PMID:25043994 PMID:28479099 PMID:33058431 PMID:33242462 PMID:34801538

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

Chlorogenic Acid inhibits the reaction [aluminum chloride results in increased expression of CASP8 protein]

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions

Chlorogenic Acid inhibits the reaction [Methotrexate results in increased activity of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in decreased activity of CAT protein]
Chlorogenic Acid inhibits the reaction [Aluminum Chloride results in decreased activity of CAT protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased expression of CAT mRNA]

PMID:28479099 PMID:28623112 PMID:31390532 PMID:33242462

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions

Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of CCL2 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]

PMID:26079055 PMID:31306686

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin D1

multiple interactions

Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of CCND1 protein]

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

CD44 molecule

increases expression

Chlorogenic Acid results in increased expression of CD44 mRNA

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

cadherin 1

increases expression

Chlorogenic Acid results in increased expression of CDH1 mRNA

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

collagen type I alpha 1 chain

increases expression
multiple interactions

Chlorogenic Acid results in increased expression of COL1A1 mRNA
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]

PMID:20706672 PMID:23146752

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type II alpha 1 chain

multiple interactions

[geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Citric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of phenylacetylglycine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein]

NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546

G

citrate synthase

increases activity

Chlorogenic Acid results in increased activity of CS protein

NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421

G

C-X-C motif chemokine ligand 3

multiple interactions

Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of CXCL1 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of CXCL1 protein]

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

cytoglobin

decreases expression

Chlorogenic Acid results in decreased expression of CYGB mRNA

NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases expression

Chlorogenic Acid results in increased expression of CYP19A1 protein

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of CYP2E1 protein]

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

DNA-damage inducible transcript 3

multiple interactions

Chlorogenic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of DDIT3 protein]; Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of DDIT3 protein]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

desmoglein 3

decreases expression

Chlorogenic Acid results in decreased expression of DSG3 mRNA

NCBI chr18:11,799,355...11,830,988
Ensembl chr18:11,798,900...11,830,818

G

epidermal growth factor

decreases expression

Chlorogenic Acid results in decreased expression of EGF mRNA

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

Chlorogenic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of EIF2AK3 protein]; Chlorogenic Acid inhibits the reaction [Glucose results in increased phosphorylation of EIF2AK3 protein]

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions

Chlorogenic Acid inhibits the reaction [Glucose results in increased phosphorylation of EIF2S1 protein]

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions

Chlorogenic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of ERN1 protein]; Chlorogenic Acid inhibits the reaction [Glucose results in increased phosphorylation of ERN1 protein]

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

endoplasmic reticulum oxidoreductase 1 alpha

multiple interactions

Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of ERO1A protein]

NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478

G

estrogen receptor 1

decreases expression

Chlorogenic Acid results in decreased expression of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

increases expression

Chlorogenic Acid results in increased expression of ESR2 protein

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

coagulation factor X

decreases activity

Chlorogenic Acid results in decreased activity of F10 protein

NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141

G

coagulation factor II, thrombin

decreases activity

Chlorogenic Acid results in decreased activity of F2 protein

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

fatty acid synthase

decreases expression

Chlorogenic Acid results in decreased expression of FASN mRNA

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

fibrillin 1

decreases expression

Chlorogenic Acid results in decreased expression of FBN1 mRNA

NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889

G

fibrillin 2

decreases expression

Chlorogenic Acid results in decreased expression of FBN2 mRNA

NCBI chr18:51,499,670...51,703,976
Ensembl chr18:51,499,737...51,703,976

G

free fatty acid receptor 1

multiple interactions

Chlorogenic Acid inhibits the reaction [Rotenone results in decreased expression of FFAR1 mRNA]

NCBI chr 1:86,111,368...86,112,272
Ensembl chr 1:86,111,368...86,112,272

G

free fatty acid receptor 2

multiple interactions

Chlorogenic Acid inhibits the reaction [Rotenone results in decreased expression of FFAR2 mRNA]

NCBI chr 1:86,071,855...86,075,049
Ensembl chr 1:86,072,184...86,075,033

G

fibroblast growth factor 1

increases expression

Chlorogenic Acid results in increased expression of FGF1 mRNA

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

G

follicle stimulating hormone subunit beta

multiple interactions

Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased expression of FSHB protein]

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

follicle stimulating hormone receptor

increases expression

Chlorogenic Acid results in increased expression of FSHR protein

NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785

G

glucagon

multiple interactions

[Chlorogenic Acid co-treated with Rotenone] results in increased secretion of GCG protein

NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929

G

glutamate-cysteine ligase, catalytic subunit

increases expression
multiple interactions

Chlorogenic Acid results in increased expression of GCLC mRNA
Chlorogenic Acid promotes the reaction [Acetaminophen results in increased expression of GCLC mRNA]

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

increases expression

Chlorogenic Acid results in increased expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glucagon-like peptide 1 receptor

multiple interactions

Chlorogenic Acid inhibits the reaction [Rotenone results in decreased expression of GLP1R protein]

NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241

G

glutamic--pyruvic transaminase

multiple interactions
decreases expression

Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased activity of GPT protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in increased activity of GPT protein]
Chlorogenic Acid results in decreased expression of GPT protein
Chlorogenic Acid inhibits the reaction [aluminum chloride results in increased activity of GPT protein]

PMID:28479099 PMID:28623112 PMID:31390532 PMID:33058431

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

multiple interactions

Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased expression of GPX1 mRNA]

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

granulin precursor

increases expression

Chlorogenic Acid results in increased expression of GRN mRNA

NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775

G

glycogen synthase kinase 3 beta

multiple interactions

Chlorogenic Acid inhibits the reaction [Rotenone results in decreased phosphorylation of GSK3B protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione-disulfide reductase

multiple interactions

Chlorogenic Acid inhibits the reaction [Methotrexate results in decreased activity of GSR protein]
Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased expression of GSR mRNA]

PMID:28479099 PMID:33242462

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

hyaluronan synthase 1

increases expression

Chlorogenic Acid results in increased expression of HAS1 mRNA

NCBI chr 1:58,693,411...58,705,653
Ensembl chr 1:58,693,411...58,705,397

G

holocarboxylase synthetase

decreases activity

Chlorogenic Acid results in decreased activity of HLCS protein

NCBI chr11:33,455,806...33,635,197
Ensembl chr11:33,455,809...33,624,222

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions
decreases expression

[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]; Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]
Chlorogenic Acid results in decreased expression of HMGCR mRNA

PMID:20696151 PMID:21870829

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

heme oxygenase 1

multiple interactions
increases expression

Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of HMOX1 protein]
Chlorogenic Acid results in increased expression of HMOX1 mRNA
Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 protein]

PMID:25043994 PMID:29136249

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein family A (Hsp70) member 5

multiple interactions

Chlorogenic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of HSPA5 protein]; Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of HSPA5 protein]

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family B (small) member 1

increases expression

Chlorogenic Acid results in increased expression of HSPB1 mRNA

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

interleukin 1 alpha

decreases expression

Chlorogenic Acid results in decreased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions

[geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of IL1B protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in increased expression of IL1B protein]

PMID:23146752 PMID:24709313 PMID:26079055 PMID:33242462

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

increases expression
multiple interactions

Chlorogenic Acid results in increased expression of IL6 mRNA
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of IL6 protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]
Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL6 protein]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]

PMID:21870829 PMID:23146752 PMID:26079055 PMID:31390532 PMID:33242462

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

integrin subunit beta 2

decreases expression
multiple interactions

Chlorogenic Acid results in decreased expression of ITGB2 protein
Chlorogenic Acid inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of ITGB2 protein]

NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

keratin 5

increases expression

Chlorogenic Acid results in increased expression of KRT5 mRNA

NCBI chr 7:132,846,132...132,851,861
Ensembl chr 7:132,846,136...132,851,850

G

lecithin cholesterol acyltransferase

multiple interactions

[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]; Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]

NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231

G

luteinizing hormone subunit beta

multiple interactions

Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased expression of LHB protein]

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

lipoprotein lipase

multiple interactions

[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein]; Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein]

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

monoamine oxidase A

decreases activity

Chlorogenic Acid results in decreased activity of MAOA protein

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

monoamine oxidase B

decreases activity

Chlorogenic Acid results in decreased activity of MAOB protein

NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003

G

mitogen activated protein kinase kinase 4

multiple interactions

Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAP2K4 protein]

NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993

G

mitogen activated protein kinase 1

multiple interactions

Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
Chlorogenic Acid promotes the reaction [Acetaminophen results in increased phosphorylation of MAPK1 protein]

PMID:15944151 PMID:29136249

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

multiple interactions

Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK14 protein]

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions

Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
Chlorogenic Acid promotes the reaction [Acetaminophen results in increased phosphorylation of MAPK3 protein]

PMID:15944151 PMID:29136249

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

Chlorogenic Acid inhibits the reaction [Glucose results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

melanocortin 1 receptor

increases expression

Chlorogenic Acid results in increased expression of MC1R mRNA

NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192

G

microsomal glutathione S-transferase 1

decreases activity

Chlorogenic Acid results in decreased activity of MGST1 protein

NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892

G

myeloperoxidase

multiple interactions

Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mitochondrially encoded cytochrome c oxidase I

increases expression

Chlorogenic Acid results in increased expression of COX1 mRNA

NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867

G

mitochondrially encoded cytochrome c oxidase II

multiple interactions

[Chlorogenic Acid co-treated with Zymosan] results in decreased expression of COX2 protein; Chlorogenic Acid inhibits the reaction [Zymosan results in increased expression of COX2 protein]

NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689

G

MYD88, innate immune signal transduction adaptor

multiple interactions

Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of MYD88 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of MYD88 protein]
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of MYD88 protein]

PMID:23146752 PMID:26079055

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

NFE2 like bZIP transcription factor 2

increases localization
multiple interactions
increases response to substance
affects localization
decreases response to substance

Chlorogenic Acid results in increased localization of NFE2L2 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Chlorogenic Acid co-treated with Acetaminophen] results in increased phosphorylation of and affects the localization of and results in increased activity of NFE2L2 protein]; [Chlorogenic Acid co-treated with Acetaminophen] results in increased activity of and affects the localization of NFE2L2 protein; [Chlorogenic Acid co-treated with Acetaminophen] results in increased phosphorylation of and affects the localization of and results in increased activity of NFE2L2 protein; U 0126 inhibits the reaction [[Chlorogenic Acid co-treated with Acetaminophen] results in increased phosphorylation of and affects the localization of and results in increased activity of NFE2L2 protein]
[Chlorogenic Acid co-treated with Acetaminophen] affects the localization of and results in increased activity of NFE2L2 protein; Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 mRNA]
NFE2L2 results in increased susceptibility to Chlorogenic Acid
Chlorogenic Acid affects the localization of NFE2L2 protein
NFE2L2 gene mutant form results in decreased susceptibility to Chlorogenic Acid

PMID:15944151 PMID:29136249 PMID:33242462

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

multiple interactions

Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of and results in increased phosphorylation of NFKBIA protein]

PMID:20026373 PMID:23146752

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NFKB inhibitor beta

multiple interactions

Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of NFKBIB protein]

NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862

G

nitric oxide synthase 2

multiple interactions

Chlorogenic Acid inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in increased expression of NOS2 mRNA]; Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein]
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in increased expression of NOS2 protein]

PMID:20026373 PMID:23146752 PMID:28479099 PMID:31306686 PMID:33242462

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

increases expression

Chlorogenic Acid results in increased expression of NOS3 mRNA

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

natriuretic peptide B

multiple interactions

Chlorogenic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of NPPB protein]

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

NAD(P)H quinone dehydrogenase 1

increases activity
increases expression
multiple interactions

Chlorogenic Acid results in increased activity of NQO1 protein
Chlorogenic Acid results in increased expression of NQO1 mRNA
Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of NQO1 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of NQO1 protein]

PMID:15944151 PMID:29136249

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group H, member 4

increases expression
increases activity

Chlorogenic Acid results in increased expression of NR1H4 mRNA
Chlorogenic Acid results in increased activity of NR1H4 protein

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

occludin

multiple interactions

Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of OCLN mRNA]; Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of OCLN protein]

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

G

prolyl 4-hydroxylase subunit beta

multiple interactions

Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of P4HB protein]

NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500

G

proliferating cell nuclear antigen

multiple interactions

Chlorogenic Acid promotes the reaction [Cisplatin results in increased expression of PCNA protein]

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

platelet and endothelial cell adhesion molecule 1

multiple interactions

Chlorogenic Acid inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PECAM1 protein]

NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116

G

progesterone receptor

increases expression
decreases expression

Chlorogenic Acid results in increased expression of PGR mRNA
Chlorogenic Acid results in decreased expression of PGR mRNA

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

phosphoinositide-3-kinase regulatory subunit 1

increases expression
multiple interactions

Chlorogenic Acid results in increased expression of PIK3R1 mRNA
Chlorogenic Acid inhibits the reaction [Rotenone results in decreased phosphorylation of PIK3R1 protein]

PMID:21870829 PMID:36048341

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3

increases expression

Chlorogenic Acid results in increased expression of PLOD3 mRNA

NCBI chr12:19,676,384...19,686,945
Ensembl chr12:19,676,386...19,686,960

G

peroxisome proliferator-activated receptor gamma

increases expression
decreases expression

Chlorogenic Acid results in increased expression of PPARG mRNA
Chlorogenic Acid results in decreased expression of PPARG mRNA

PMID:20706672 PMID:21870829

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein phosphatase 2 scaffold subunit A alpha

multiple interactions

[Chlorogenic Acid co-treated with Acetaminophen] results in decreased expression of PPP2R1A protein

NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129

G

protein phosphatase 5, catalytic subunit

multiple interactions

[Chlorogenic Acid co-treated with Acetaminophen] results in decreased expression of PPP5C protein

NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in increased expression of PTGS2 protein]
Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of and results in increased expression of PTGS2 protein]

PMID:20026373 PMID:23146752 PMID:25043994 PMID:28479099 PMID:31306686

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RAD23 homolog A, nucleotide excision repair protein

decreases expression

Chlorogenic Acid results in decreased expression of RAD23A mRNA

NCBI chr19:23,313,563...23,320,702
Ensembl chr19:23,314,797...23,320,695

G

retinoic acid receptor, alpha

increases expression

Chlorogenic Acid results in increased expression of RARA mRNA

NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of and results in increased phosphorylation of and affects the localization of RELA protein]; Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein]

PMID:20026373 PMID:26079055

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

reticulophagy regulator 1

multiple interactions

Chlorogenic Acid inhibits the reaction [Glucose results in decreased expression of RETREG1 protein]

NCBI chr 2:76,335,609...76,474,817
Ensembl chr 2:76,335,609...76,493,898

G

reticulon 3

multiple interactions

Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of RTN3 protein]

NCBI chr 1:204,612,675...204,669,212
Ensembl chr 1:204,612,675...204,669,275

G

retinoid X receptor alpha

decreases expression

Chlorogenic Acid results in decreased expression of RXRA mRNA

NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712

G

SEC62 homolog, preprotein translocation factor

multiple interactions

Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of SEC62 protein]

NCBI chr 2:112,570,810...112,598,198
Ensembl chr 2:112,570,819...112,601,814

G

selectin L

multiple interactions

[Chlorogenic Acid co-treated with lipopolysaccharide, E. coli O26-B6] results in increased expression of SELL protein; Chlorogenic Acid inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased expression of SELL protein]

NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456

G

solute carrier family 11 member 2

multiple interactions

Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC11A2 mRNA]; Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC11A2 protein]

NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145

G

solute carrier family 22 member 2

multiple interactions

Chlorogenic Acid inhibits the reaction [Cisplatin results in decreased expression of SLC22A2 protein]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 2 member 4

increases expression

Chlorogenic Acid results in increased expression of SLC2A4 mRNA

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

synuclein alpha

multiple interactions

Chlorogenic Acid inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Chlorogenic Acid inhibits the reaction [Rotenone results in increased phosphorylation of SNCA protein]

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

superoxide dismutase 2

increases expression
multiple interactions

Chlorogenic Acid results in increased expression of SOD2 mRNA
Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased expression of SOD2 mRNA]

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

superoxide dismutase 3

decreases expression

Chlorogenic Acid results in decreased expression of SOD3 mRNA

NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990

G

sequestosome 1

multiple interactions

Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of SQSTM1 protein]

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

steroid 5 alpha-reductase 2

decreases expression

Chlorogenic Acid results in decreased expression of SRD5A2 mRNA

NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112

G

steroidogenic acute regulatory protein

increases expression

Chlorogenic Acid results in increased expression of STAR protein

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

tight junction protein 1

multiple interactions

Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TJP1 mRNA]; Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TJP1 protein]

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

toll-like receptor 3

multiple interactions

Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of TLR3 protein]

NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545

G

toll-like receptor 4

multiple interactions

Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 protein]
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of TLR4 protein]

PMID:23146752 PMID:26079055

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

increases expression
multiple interactions

Chlorogenic Acid results in increased expression of TNF mRNA
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of TNF protein]; Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in increased expression of TNF protein]
Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF protein]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]

PMID:21870829 PMID:23146752 PMID:25043994 PMID:26079055 PMID:31306686 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

multiple interactions
increases expression

Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of TRP53 protein]
Chlorogenic Acid results in increased expression of TRP53 mRNA

PMID:25043994 PMID:33058431

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tumor protein, translationally-controlled 1

increases expression

Chlorogenic Acid results in increased expression of TPT1 mRNA

NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625

G

Tnf receptor-associated factor 2

multiple interactions

Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of TRAF2 protein]

NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538

G

thioredoxin 1

increases expression

Chlorogenic Acid results in increased expression of TXN mRNA

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

tyrosinase

increases oxidation
multiple interactions

TYR protein results in increased oxidation of Chlorogenic Acid
[TYR protein results in increased oxidation of Chlorogenic Acid] which results in decreased abundance of Glutathione

NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207

G

tyrosinase-related protein 1

decreases expression

Chlorogenic Acid results in decreased expression of TYRP1 mRNA

NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516

G

UDP glucuronosyltransferase family 1 member A1

decreases activity

Chlorogenic Acid results in decreased activity of UGT1A1 protein

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation
decreases activity

UGT1A3 protein results in increased glucuronidation of Chlorogenic Acid
Chlorogenic Acid results in decreased activity of UGT1A3 protein

PMID:15117964 PMID:35868516

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A6

decreases activity

Chlorogenic Acid results in decreased activity of UGT1A6 protein

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

decreases activity

Chlorogenic Acid results in decreased activity of UGT1A9 protein

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 2 family, polypeptide B1

decreases activity

Chlorogenic Acid results in decreased activity of UGT2B17 protein

NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986

G

UDP glucuronosyltransferase family 2 member B7

decreases activity

Chlorogenic Acid results in decreased activity of UGT2B7 protein

NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604

G

X-box binding protein 1

multiple interactions

Chlorogenic Acid inhibits the reaction [Glucose results in increased expression of XBP1 mRNA]

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

ethyl trans-caffeate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

ethyl caffeate affects the phosphorylation of and affects the activity of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

cadherin 2

affects expression

ethyl caffeate affects the expression of CDH2 protein

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cyclin dependent kinase 2

affects expression

ethyl caffeate affects the expression of CDK2 protein

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 4

affects expression

ethyl caffeate affects the expression of CDK4 protein

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

erb-b2 receptor tyrosine kinase 2

affects expression
multiple interactions

ethyl caffeate affects the expression of ERBB2 protein
ethyl caffeate affects the phosphorylation of and affects the activity of ERBB2 protein

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

Fibroblast growth factor receptor 1

affects expression

ethyl caffeate affects the expression of FGFR1 protein

NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350

G

integrin-linked kinase

affects expression

ethyl caffeate affects the expression of ILK protein

NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140

G

integrin subunit alpha 3

multiple interactions

ethyl caffeate affects the expression of [ITGA3 protein binds to ITGB1 protein]

NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118

G

integrin subunit beta 1

multiple interactions

ethyl caffeate affects the expression of [ITGA3 protein binds to ITGB1 protein]

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

kinase insert domain receptor

affects expression

ethyl caffeate affects the expression of KDR protein

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

mitogen activated protein kinase 1

multiple interactions

ethyl caffeate affects the phosphorylation of and affects the activity of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

ethyl caffeate affects the phosphorylation of and affects the activity of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

RB transcriptional corepressor 1

affects phosphorylation

ethyl caffeate affects the phosphorylation of RB1 protein

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

rosmarinic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA carboxylase alpha

multiple interactions

Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ACACA mRNA]

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

actin alpha 2, smooth muscle

decreases expression
multiple interactions

Rosmarinic Acid results in decreased expression of ACTA2 protein
Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

ADAM metallopeptidase domain 17

decreases expression
multiple interactions

Rosmarinic Acid results in decreased expression of ADAM17 protein
[Rosmarinic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which affects the localization of PROCR protein; [Rosmarinic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which results in decreased cleavage of and results in decreased secretion of PROCR protein; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein affects the localization of PROCR protein]; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein results in increased cleavage of and results in increased secretion of PROCR protein]; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein]; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein]; Rosmarinic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]

NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639

G

adiponectin, C1Q and collagen domain containing

multiple interactions

Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ protein]

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions

Rosmarinic Acid inhibits the reaction [Cadmium affects the localization of AIFM1 protein]; Rosmarinic Acid inhibits the reaction [Cisplatin affects the localization of AIFM1 protein]

PMID:21526214 PMID:23548128

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

BCL2 associated X, apoptosis regulator

multiple interactions

Rosmarinic Acid inhibits the reaction [Cisplatin results in increased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

Rosmarinic Acid inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 1

multiple interactions

Rosmarinic Acid inhibits the reaction [Cisplatin results in increased activity of CASP1 protein]

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

multiple interactions
increases expression

Rosmarinic Acid inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]; Rosmarinic Acid inhibits the reaction [Cadmium results in increased activity of CASP3 protein]; Rosmarinic Acid inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]
Rosmarinic Acid inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]
Rosmarinic Acid results in increased expression of CASP3 mRNA

PMID:20966113 PMID:21526214 PMID:23548128 PMID:28815802 PMID:36863647

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases expression
increases activity

Rosmarinic Acid results in increased expression of CASP8 mRNA
Rosmarinic Acid results in increased activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions

Rosmarinic Acid inhibits the reaction [Cisplatin results in increased activity of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

increases activity
increases expression
multiple interactions

Rosmarinic Acid results in increased activity of CAT protein
Rosmarinic Acid results in increased expression of CAT mRNA
Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased activity of CAT protein]; Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of CAT mRNA]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cellular communication network factor 2

multiple interactions
decreases expression

Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]
Rosmarinic Acid results in decreased expression of CCN2 mRNA

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cyclin D1

multiple interactions

Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein]

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

Cd68 molecule

decreases expression

Rosmarinic Acid results in decreased expression of CD68 protein

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

G

CCAAT/enhancer binding protein alpha

multiple interactions

Rosmarinic Acid affects the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA protein]

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

collagen type I alpha 1 chain

decreases expression
multiple interactions

Rosmarinic Acid results in decreased expression of COL1A1 mRNA
Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]

PMID:27235791 PMID:28789951

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type III alpha 1 chain

multiple interactions
decreases expression

Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]
Rosmarinic Acid results in decreased expression of COL3A1 mRNA

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

C-reactive protein

affects expression
multiple interactions

Rosmarinic Acid affects the expression of CRP protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Rosmarinic Acid affects the expression of CRP protein]; T 0070907 inhibits the reaction [Rosmarinic Acid affects the expression of CRP protein]

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

C-X-C motif chemokine ligand 3

decreases expression
multiple interactions

Rosmarinic Acid results in decreased expression of CXCL1 mRNA
Rosmarinic Acid inhibits the reaction [Particulate Matter results in increased expression of CXCL1 protein]; Rosmarinic Acid inhibits the reaction [Vehicle Emissions results in increased expression of CXCL1 protein]

PMID:12684091 PMID:26804033

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

desmin

multiple interactions

Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of DES protein]

NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699

G

DNA methyltransferase 1

decreases expression

Rosmarinic Acid results in decreased expression of DNMT1 protein

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

fatty acid binding protein 4

multiple interactions

Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FABP4 mRNA]

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

fatty acid synthase

multiple interactions

Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FASN mRNA]

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

fibronectin 1

decreases expression

Rosmarinic Acid results in decreased expression of FN1 mRNA

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression

Rosmarinic Acid results in decreased expression of FOS protein

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

glutamic--pyruvic transaminase

decreases activity

Rosmarinic Acid results in decreased activity of GPT protein

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

increases expression
multiple interactions

Rosmarinic Acid results in increased expression of GPX1 mRNA
Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GPX1 mRNA]

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione S-transferase omega 1

multiple interactions
increases expression

Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GSTO1 mRNA]
Rosmarinic Acid results in increased expression of GSTO1 mRNA

NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468

G

high mobility group box 1

decreases expression

Rosmarinic Acid results in decreased expression of HMGB1 protein

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

heme oxygenase 1

increases expression
multiple interactions

Rosmarinic Acid results in increased expression of HMOX1 mRNA
Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of HMOX1 mRNA]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

interleukin 10

multiple interactions

Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of IL10 mRNA]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 17A

multiple interactions

Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of IL17A mRNA]

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 1 beta

multiple interactions
decreases expression

[Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein affects the localization of PROCR protein]; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein results in increased cleavage of and results in increased secretion of PROCR protein]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of IL1B mRNA]
Rosmarinic Acid inhibits the reaction [Cadmium results in increased expression of IL1B protein]; Rosmarinic Acid inhibits the reaction [Particulate Matter results in increased expression of IL1B protein]; Rosmarinic Acid inhibits the reaction [Vehicle Emissions results in increased expression of IL1B protein]
Rosmarinic Acid results in decreased expression of IL1B mRNA; Rosmarinic Acid results in decreased expression of IL1B protein

PMID:12684091 PMID:23548128 PMID:23774263 PMID:25455894 PMID:28789951 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions
affects expression
increases expression
decreases expression

Rosmarinic Acid inhibits the reaction [Cadmium results in increased expression of IL6 protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [Rosmarinic Acid affects the expression of IL6 protein]; T 0070907 inhibits the reaction [Rosmarinic Acid affects the expression of IL6 protein]
Rosmarinic Acid results in increased expression of IL6 mRNA
Rosmarinic Acid results in decreased expression of IL6 mRNA
Rosmarinic Acid results in decreased expression of IL6 protein

PMID:23548128 PMID:26804033 PMID:28744220 PMID:28789951

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 2

multiple interactions

[Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of NFE2L2 mRNA; [Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of TGFB1 mRNA; [Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of NFKBIA mRNA; Rosmarinic Acid affects the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA mRNA]; Rosmarinic Acid affects the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARGC1A mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of IL10 mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of IL17A mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ACACA mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ protein]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA protein]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FABP4 mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FASN mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of IL1B mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARA mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARD mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARG protein]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of SREBF1 mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of UCP1 mRNA]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases phosphorylation

Rosmarinic Acid results in decreased phosphorylation of JUN protein

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

potassium calcium-activated channel subfamily U member 1

decreases activity

Rosmarinic Acid results in decreased activity of KCNU1 protein

NCBI chr16:66,141,696...66,229,493
Ensembl chr16:66,141,976...66,229,465

G

Kelch-like ECH-associated protein 1

decreases expression
multiple interactions

Rosmarinic Acid results in decreased expression of KEAP1 protein
Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 protein]

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

monoamine oxidase A

decreases activity

Rosmarinic Acid results in decreased activity of MAOA protein

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

monoamine oxidase B

decreases activity

Rosmarinic Acid results in decreased activity of MAOB protein

NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003

G

mitogen activated protein kinase kinase kinase 7

decreases phosphorylation

Rosmarinic Acid results in decreased phosphorylation of MAP3K7 protein

NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597

G

mitogen activated protein kinase 1

decreases phosphorylation

Rosmarinic Acid results in decreased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

decreases phosphorylation

Rosmarinic Acid results in decreased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

decreases phosphorylation

Rosmarinic Acid results in decreased phosphorylation of MAPK8 protein

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

decreases phosphorylation

Rosmarinic Acid results in decreased phosphorylation of MAPK9 protein

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

matrix metallopeptidase 2

decreases expression

Rosmarinic Acid results in decreased expression of MMP2 mRNA; Rosmarinic Acid results in decreased expression of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

decreases expression

Rosmarinic Acid results in decreased expression of MMP9 mRNA; Rosmarinic Acid results in decreased expression of MMP9 protein

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

decreases expression

Rosmarinic Acid results in decreased expression of MPO protein

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

MYD88, innate immune signal transduction adaptor

decreases expression

Rosmarinic Acid results in decreased expression of MYD88 protein

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

NFE2 like bZIP transcription factor 2

increases expression
multiple interactions

Rosmarinic Acid results in increased expression of NFE2L2 mRNA; Rosmarinic Acid results in increased expression of NFE2L2 protein
[lead acetate results in increased abundance of Lead] inhibits the reaction [Rosmarinic Acid results in increased expression of NFE2L2 protein]; [Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of NFE2L2 mRNA; Rosmarinic Acid affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 mRNA]

PMID:31610155 PMID:33476690

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

multiple interactions

[Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of NFKBIA mRNA
Rosmarinic Acid inhibits the reaction [Cisplatin results in increased degradation of NFKBIA protein]

PMID:21526214 PMID:33476690

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NLR family, pyrin domain containing 3

decreases expression

Rosmarinic Acid results in decreased expression of NLRP3 mRNA

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

nitric oxide synthase 2

multiple interactions
decreases expression

Rosmarinic Acid inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]
Rosmarinic Acid results in decreased expression of NOS2 protein

PMID:25455894 PMID:28815802

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

decreases expression

Rosmarinic Acid results in decreased expression of NOS3 protein

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of NQO1 mRNA]
Rosmarinic Acid results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

8-oxoguanine DNA glycosylase

increases expression

Rosmarinic Acid results in increased expression of OGG1 mRNA

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

G

poly (ADP-ribose) glycohydrolase

decreases activity

Rosmarinic Acid results in decreased activity of PARG protein

NCBI chr16:7,436,429...7,544,276
Ensembl chr16:7,436,476...7,544,273

G

peroxisome proliferator activated receptor alpha

multiple interactions

Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARA mRNA]

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor delta

multiple interactions

Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARD mRNA]

NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968

G

peroxisome proliferator-activated receptor gamma

affects expression
multiple interactions

Rosmarinic Acid affects the expression of PPARG mRNA; Rosmarinic Acid affects the expression of PPARG protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Rosmarinic Acid affects the expression of PPARG mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Rosmarinic Acid affects the expression of PPARG protein]; T 0070907 inhibits the reaction [Rosmarinic Acid affects the expression of PPARG mRNA]; T 0070907 inhibits the reaction [Rosmarinic Acid affects the expression of PPARG protein]
Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARG protein]

PMID:28744220 PMID:33476690

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PPARG coactivator 1 alpha

multiple interactions

Rosmarinic Acid affects the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARGC1A mRNA]

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

protein C receptor

affects localization
multiple interactions

Rosmarinic Acid affects the localization of PROCR protein
[Rosmarinic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which affects the localization of PROCR protein; [Rosmarinic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which results in decreased cleavage of and results in decreased secretion of PROCR protein; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein affects the localization of PROCR protein]; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein results in increased cleavage of and results in increased secretion of PROCR protein]; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein]; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein]; Rosmarinic Acid inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PROCR protein]; Rosmarinic Acid results in decreased cleavage of and results in decreased secretion of PROCR protein

NCBI chr 3:144,254,596...144,258,863
Ensembl chr 3:144,254,380...144,258,903

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
affects localization
decreases phosphorylation
affects expression

2-chloro-5-nitrobenzanilide inhibits the reaction [Rosmarinic Acid affects the expression of RELA mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Rosmarinic Acid affects the expression of RELA protein]; T 0070907 inhibits the reaction [Rosmarinic Acid affects the expression of RELA mRNA]; T 0070907 inhibits the reaction [Rosmarinic Acid affects the expression of RELA protein]
Rosmarinic Acid affects the localization of RELA protein
Rosmarinic Acid results in decreased phosphorylation of RELA protein
Rosmarinic Acid affects the expression of RELA mRNA; Rosmarinic Acid affects the expression of RELA protein
Rosmarinic Acid inhibits the reaction [Cisplatin affects the localization of RELA protein]

PMID:21526214 PMID:25455894 PMID:28744220 PMID:28789951

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

serpin family E member 1

decreases expression

Rosmarinic Acid results in decreased expression of SERPINE1 mRNA

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

superoxide dismutase 1

multiple interactions
increases expression

Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SOD1 mRNA]
Rosmarinic Acid results in increased expression of SOD1 mRNA

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions
increases expression

Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SOD2 mRNA]
Rosmarinic Acid results in increased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

sterol regulatory element binding transcription factor 1

multiple interactions

Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of SREBF1 mRNA]

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

transferrin

multiple interactions

[Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of NFE2L2 mRNA; [Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of TGFB1 mRNA; [Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of NFKBIA mRNA; Rosmarinic Acid affects the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA mRNA]; Rosmarinic Acid affects the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARGC1A mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of IL10 mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of IL17A mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ACACA mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ protein]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA protein]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FABP4 mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FASN mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of IL1B mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARA mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARD mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARG protein]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of SREBF1 mRNA]; Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of UCP1 mRNA]

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

transforming growth factor, beta 1

decreases expression
multiple interactions

Rosmarinic Acid results in decreased expression of TGFB1 protein
Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]; Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein]; Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of DES protein]; Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]
[Rosmarinic Acid co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of TGFB1 mRNA

PMID:28789951 PMID:33476690

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

toll-like receptor 4

decreases expression

Rosmarinic Acid results in decreased expression of TLR4 protein

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

affects expression
multiple interactions
decreases expression

Rosmarinic Acid affects the expression of TNF protein
[Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein]; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [Rosmarinic Acid affects the expression of TNF protein]; Rosmarinic Acid inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; T 0070907 inhibits the reaction [Rosmarinic Acid affects the expression of TNF protein]
Rosmarinic Acid results in decreased expression of TNF mRNA; Rosmarinic Acid results in decreased expression of TNF protein

PMID:23774263 PMID:25455894 PMID:28744220 PMID:28789951 PMID:28815802

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

uncoupling protein 1

multiple interactions

Rosmarinic Acid inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of UCP1 mRNA]

NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852

G

vimentin

multiple interactions

Rosmarinic Acid inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19811
role	19818
chemical role	19422
antioxidant	16120
caffeic acid	595
trans-caffeic acid	293
(2S,3R)-trans-caftaric acid	0
1,3,4,5-tetracaffeoylquinic acid	0
1,3-dicaffeoylquinic acid	0
1-O-caffeoylquinic acid	0
1-caffeoyl-5-feruloylquinic acid	0
1-caffeoyl-beta-D-glucose	0
2-O-caffeoyl maslinic acid	0
3,4-dihydroxy-5-prenylcinnamic acid	0
3,5-di-O-caffeoyl quinic acid +	0
3-O-beta-D-glucosyl-trans-caffeic acid	0
4-O-beta-D-glucosyl-trans-caffeic acid	0
4-O-trans-caffeoylquinic acid +	0
5-[(E)-caffeoyl]shikimic acid	0
7-O-[6-(6-methoxycaffeoyl)glucosyl]isovitexin	0
Cuscuta propenamide 1	0
N(1),N(8)-bis(caffeoyl)spermidine	0
N-caffeoylspermidine	0
acteoside	45
caffeic acid 3-sulfate	0
caffeic acid 3-sulfate(2-)	0
caffeoylglycolic acid methyl ester	0
calabricoside B	0
chlorogenic acid	141
ethyl trans-caffeate	13
evolvoid A	0
gelsemiol-6'-trans-caffeoyl-1-glucoside	0
litseaefoloside C	0
malvidin 3-O-\	0
methyl 3,4-dicaffeoylquinate	0
quercetin 3-O-[(6-O-caffeoyl-beta-D-glucosyl)-(1->2)-beta-D-glucoside]	0
quercetin 3-O-alpha-(6'''-caffeoylglucosyl-beta-1,2-rhamnoside)	0
rosmarinic acid +	74
subulatin	0
trans-5-O-caffeoyl-D-quinic acid	0
trans-caffeoyl-CoA	0
Path 2
Term	Annotations
CHEBI ontology	19811
subatomic particle	19809
composite particle	19809
hadron	19840
baryon	19809
nucleon	19809
atomic nucleus	19809
atom	19809
main group element atom	19759
p-block element atom	19759
carbon group element atom	19708
carbon atom	19734
organic molecular entity	19705
heteroorganic entity	19459
organochalcogen compound	19222
organooxygen compound	19137
carbon oxoacid	18597
carboxylic acid	18594
monocarboxylic acid	17952
alpha,beta-unsaturated monocarboxylic acid	13440
cinnamic acids	2510
hydroxycinnamic acid	1364
caffeic acid	595
trans-caffeic acid	293
(2S,3R)-trans-caftaric acid	0
1,3,4,5-tetracaffeoylquinic acid	0
1,3-dicaffeoylquinic acid	0
1-O-caffeoylquinic acid	0
1-caffeoyl-5-feruloylquinic acid	0
1-caffeoyl-beta-D-glucose	0
2-O-caffeoyl maslinic acid	0
3,4-dihydroxy-5-prenylcinnamic acid	0
3,5-di-O-caffeoyl quinic acid +	0
3-O-beta-D-glucosyl-trans-caffeic acid	0
4-O-beta-D-glucosyl-trans-caffeic acid	0
4-O-trans-caffeoylquinic acid +	0
5-[(E)-caffeoyl]shikimic acid	0
7-O-[6-(6-methoxycaffeoyl)glucosyl]isovitexin	0
Cuscuta propenamide 1	0
N(1),N(8)-bis(caffeoyl)spermidine	0
N-caffeoylspermidine	0
acteoside	45
caffeic acid 3-sulfate	0
caffeic acid 3-sulfate(2-)	0
caffeoylglycolic acid methyl ester	0
calabricoside B	0
chlorogenic acid	141
ethyl trans-caffeate	13
evolvoid A	0
gelsemiol-6'-trans-caffeoyl-1-glucoside	0
litseaefoloside C	0
malvidin 3-O-\	0
methyl 3,4-dicaffeoylquinate	0
quercetin 3-O-[(6-O-caffeoyl-beta-D-glucosyl)-(1->2)-beta-D-glucoside]	0
quercetin 3-O-alpha-(6'''-caffeoylglucosyl-beta-1,2-rhamnoside)	0
rosmarinic acid +	74
subulatin	0
trans-5-O-caffeoyl-D-quinic acid	0
trans-caffeoyl-CoA	0

paths to the root