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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:trans-caffeic acid
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Accession:CHEBI:16433 term browser browse the term
Definition:The trans-isomer of caffeic acid.
Synonyms:exact_synonym: (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
 related_synonym: 3,4-Dihydroxy-trans-cinnamate;   3,4-Dihydroxycinnamic acid;   CAFFEIC ACID;   Formula=C9H8O4;   InChI=1S/C9H8O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1-5,10-11H,(H,12,13)/b4-2+;   InChIKey=QAIPRVGONGVQAS-DUXPYHPUSA-N;   SMILES=OC(=O)\\C=C\\c1ccc(O)c(O)c1;   trans-Caffeate
 alt_id: CHEBI:11691;   CHEBI:11692;   CHEBI:12870;   CHEBI:1379;   CHEBI:19877;   CHEBI:41964
 xref: Beilstein:1954563;   CAS:331-39-5;   CAS:501-16-6;   HMDB:HMDB0001964;   KEGG:C01197;   KEGG:C01481;   KNApSAcK:C00000615
 xref_mesh: MESH:C040048
 xref: PDBeChem:DHC;   Reaxys:1954563;   Wikipedia:Caffeic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:57770


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trans-caffeic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO caffeic acid results in increased phosphorylation of and results in decreased activity of ACACA protein CTD PMID:28576465 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Ache acetylcholinesterase multiple interactions
decreases activity
EXP caffeic acid inhibits the reaction [Caffeine results in decreased activity of ACHE protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of ACHE protein] CTD PMID:28465162 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acly ATP citrate lyase multiple interactions ISO [Metformin co-treated with caffeic acid] results in decreased expression of ACLY protein CTD PMID:28576465 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Alox15 arachidonate 15-lipoxygenase decreases activity
multiple interactions
ISO caffeic acid results in decreased activity of ALOX15 protein
[caffeic acid results in decreased activity of ALOX15 protein] inhibits the reaction [vorinostat results in increased activity of CASP3 protein]; [caffeic acid results in decreased activity of ALOX15 protein] which results in decreased chemical synthesis of 13-hydroxy-9,11-octadecadienoic acid; [caffeic acid results in decreased activity of ALOX15 protein] which results in increased abundance of 13-hydroxy-9,11-octadecadienoic acid; caffeic acid inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased activity of ALOX15 protein]
CTD PMID:10904086, PMID:11406566, PMID:15574791 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO
EXP
caffeic acid inhibits the reaction [aluminum chloride results in increased expression of ALOX5 mRNA]; caffeic acid inhibits the reaction [aluminum chloride results in increased expression of ALOX5 protein]
caffeic acid inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein]; caffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 mRNA]; caffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 protein]; caffeic acid inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein]
CTD PMID:18482095, PMID:18951527, PMID:27368151 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO caffeic acid inhibits the reaction [aluminum chloride results in increased expression of APP protein modified form]; caffeic acid inhibits the reaction [aluminum chloride results in increased expression of APP protein] CTD PMID:18482095 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arg1 arginase 1 decreases activity ISO caffeic acid results in decreased activity of ARG1 protein CTD PMID:27378625 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of ATP6V0D2 mRNA] CTD PMID:19442820 NCBI chr 5:33,843,591...33,892,446
Ensembl chr 5:33,843,519...33,892,462
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
[caffeic acid results in decreased activity of ALOX15 protein] inhibits the reaction [vorinostat results in increased activity of CASP3 protein]
caffeic acid inhibits the reaction [Valproic Acid results in increased expression of CASP3 protein]
CTD PMID:15574791, PMID:29968957 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions
increases activity
ISO
EXP
caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [CAT protein results in increased metabolism of Hydrogen Peroxide]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of CAT protein]
caffeic acid results in increased activity of CAT protein
caffeic acid inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; caffeic acid inhibits the reaction [Nickel results in decreased activity of CAT protein]
CTD PMID:18405891, PMID:21640567, PMID:22036979, PMID:27378625 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [Resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL2 mRNA; caffeic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] CTD PMID:16806235, PMID:31306686 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO [resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL3 mRNA CTD PMID:16806235 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO [resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL4 mRNA CTD PMID:16806235 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 multiple interactions ISO [resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR1 mRNA CTD PMID:16806235 NCBI chr 8:132,996,646...133,002,201
Ensembl chr 8:132,996,649...133,002,201
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 multiple interactions ISO [resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR2 mRNA CTD PMID:16806235
G Ccr4 C-C motif chemokine receptor 4 multiple interactions ISO [resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR4 mRNA CTD PMID:16806235 NCBI chr 8:122,530,152...122,535,959
Ensembl chr 8:122,530,624...122,532,070
JBrowse link
G Cd4 Cd4 molecule multiple interactions ISO [resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CD4 mRNA CTD PMID:16806235 NCBI chr 4:157,381,862...157,408,357
Ensembl chr 4:157,383,052...157,408,176
JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO [resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CD68 mRNA CTD PMID:16806235 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
JBrowse link
G Cdc20 cell division cycle 20 multiple interactions ISO [Thapsigargin co-treated with caffeic acid] results in increased expression of CDC20 mRNA CTD PMID:19442820 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in increased expression of CDK2 mRNA] CTD PMID:19442820 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Chat choline O-acetyltransferase multiple interactions ISO caffeic acid inhibits the reaction [aluminum chloride results in decreased expression of CHAT protein] CTD PMID:18482095 NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131
JBrowse link
G Comt catechol-O-methyltransferase increases methylation ISO COMT protein results in increased methylation of caffeic acid CTD PMID:11160877 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Crh corticotropin releasing hormone multiple interactions EXP caffeic acid inhibits the reaction [Malathion results in decreased expression of CRH mRNA] CTD PMID:25404496 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of CTF1 mRNA] CTD PMID:19442820 NCBI chr 1:199,162,319...199,168,296
Ensembl chr 1:199,163,086...199,168,296
JBrowse link
G Ctsb cathepsin B multiple interactions EXP caffeic acid inhibits the reaction [Isoproterenol results in increased activity of CTSB protein] CTD PMID:20391626 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Ctsd cathepsin D multiple interactions EXP caffeic acid inhibits the reaction [Isoproterenol affects the activity of CTSD protein] CTD PMID:20391626 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of CXCL2 mRNA] CTD PMID:19442820 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP caffeic acid inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine] CTD PMID:7710944 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Dap death-associated protein multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of DAP mRNA] CTD PMID:19442820 NCBI chr 2:84,275,884...84,328,998
Ensembl chr 2:84,275,884...84,328,998
JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of DNAJB11 mRNA] CTD PMID:19442820 NCBI chr11:81,741,342...81,757,806
Ensembl chr11:81,741,297...81,757,813
JBrowse link
G Dpysl4 dihydropyrimidinase-like 4 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in increased expression of DPYSL4 mRNA] CTD PMID:19442820 NCBI chr 1:211,423,022...211,438,533
Ensembl chr 1:211,423,022...211,438,531
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO [resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of EDN1 mRNA CTD PMID:16806235 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO caffeic acid affects the reaction [Acetaminophen results in increased expression of and affects the localization of EGR1 protein]; caffeic acid inhibits the reaction [Acetaminophen results in increased expression of EGR1 mRNA] CTD PMID:27720869 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Elmo2 engulfment and cell motility 2 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of ELMO2 mRNA] CTD PMID:19442820 NCBI chr 3:161,812,474...161,850,006
Ensembl chr 3:161,812,474...162,003,588
JBrowse link
G Erf Ets2 repressor factor multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in increased expression of ERF mRNA] CTD PMID:19442820 NCBI chr 1:82,112,449...82,120,902
Ensembl chr 1:82,112,449...82,120,902
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO caffeic acid inhibits the reaction [Acetaminophen results in increased expression of F3 protein] CTD PMID:27720869 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fasn fatty acid synthase decreases expression
multiple interactions
ISO caffeic acid results in decreased expression of FASN mRNA
[Metformin co-treated with caffeic acid] results in decreased expression of FASN protein
CTD PMID:21870829, PMID:28576465 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Flrt2 fibronectin leucine rich transmembrane protein 2 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of FLRT2 mRNA] CTD PMID:19442820 NCBI chr 6:119,518,459...119,613,534
Ensembl chr 6:119,519,714...119,609,296
JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of FLT4 mRNA] CTD PMID:19442820 NCBI chr10:35,078,782...35,120,296
Ensembl chr10:35,078,726...35,121,599
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity ISO caffeic acid results in decreased activity of G6PD protein CTD PMID:25130191 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO caffeic acid inhibits the reaction [Acetaminophen results in increased expression of GADD45A mRNA]; caffeic acid inhibits the reaction [Acetaminophen results in increased expression of GADD45A protein] CTD PMID:27720869 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions EXP caffeic acid inhibits the reaction [Isoproterenol affects the activity of GLB1 protein] CTD PMID:20391626 NCBI chr 8:122,439,328...122,511,939
Ensembl chr 8:122,439,328...122,511,939
JBrowse link
G Gls glutaminase increases expression ISO caffeic acid results in increased expression of GLS protein CTD PMID:28576465 NCBI chr 9:54,212,622...54,284,879
Ensembl chr 9:54,212,767...54,284,872
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions EXP caffeic acid inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GOT1 protein] CTD PMID:15212457 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO
caffeic acid inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GPT protein]
caffeic acid inhibits the reaction [Acetaminophen results in increased activity of GPT protein]
CTD PMID:15212457, PMID:27720869 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP
ISO
caffeic acid inhibits the reaction [Cisplatin results in decreased activity of GSR protein]
caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [GSR protein results in increased oxidation of NADP]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of GSR protein]
caffeic acid promotes the reaction [Thapsigargin results in decreased expression of GSR mRNA]
CTD PMID:19442820, PMID:21640567, PMID:22036979 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity EXP caffeic acid results in decreased activity of GSTM1 protein CTD PMID:8340025 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases activity EXP caffeic acid results in decreased activity of GSTM2 protein CTD PMID:8340025 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity EXP caffeic acid results in decreased activity of GSTP1 protein CTD PMID:8340025 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gusb glucuronidase, beta multiple interactions EXP caffeic acid inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:20391626 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771
JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) multiple interactions EXP caffeic acid inhibits the reaction [Cisplatin results in decreased activity of H6PD protein] CTD PMID:21640567 NCBI chr 5:166,994,683...167,030,441
Ensembl chr 5:166,998,881...167,030,441
JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 multiple interactions ISO [resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of HAVCR2 mRNA CTD PMID:16806235 NCBI chr10:31,561,838...31,590,624
Ensembl chr10:31,561,895...31,588,943
JBrowse link
G Hes1 hes family bHLH transcription factor 1 multiple interactions EXP caffeic acid inhibits the reaction [Valproic Acid results in increased expression of HES1 mRNA] CTD PMID:29968957 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Hlcs holocarboxylase synthetase decreases activity ISO caffeic acid results in decreased activity of HLCS protein CTD PMID:26303405 NCBI chr11:34,357,372...34,537,798
Ensembl chr11:34,352,287...34,526,931
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression ISO caffeic acid results in decreased expression of HMGCR mRNA CTD PMID:21870829 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of HSP90B1 mRNA] CTD PMID:19442820 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in increased expression of HSPE1 mRNA] CTD PMID:19442820 NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599
JBrowse link
G Ifng interferon gamma increases expression
multiple interactions
ISO
EXP
caffeic acid results in increased expression of IFNG protein
caffeic acid inhibits the reaction [Valproic Acid results in increased expression of IFNG protein]
CTD PMID:27378625, PMID:29968957 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 decreases expression ISO caffeic acid results in decreased expression of IL10 protein CTD PMID:27378625 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
caffeic acid inhibits the reaction [Acetaminophen results in increased expression of IL1B protein]
caffeic acid inhibits the reaction [Aluminum results in increased expression of IL1B protein]
CTD PMID:27368151, PMID:27720869 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 increases expression ISO caffeic acid results in increased expression of IL2 protein CTD PMID:27378625 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il21r interleukin 21 receptor multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of IL21R mRNA] CTD PMID:19442820 NCBI chr 1:196,996,405...197,024,185
Ensembl chr 1:196,996,581...197,024,166
JBrowse link
G Il4 interleukin 4 decreases expression ISO caffeic acid results in decreased expression of IL4 protein CTD PMID:27378625 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO
EXP
caffeic acid results in increased expression of IL6 mRNA
caffeic acid inhibits the reaction [Acetaminophen results in increased expression of IL6 protein]
caffeic acid inhibits the reaction [Aluminum results in increased expression of IL6 protein]
CTD PMID:21870829, PMID:27368151, PMID:27720869 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kif15 kinesin family member 15 multiple interactions ISO [Thapsigargin co-treated with caffeic acid] results in increased expression of KIF15 mRNA CTD PMID:19442820 NCBI chr 8:132,033,117...132,103,528
Ensembl chr 8:132,032,944...132,103,927
JBrowse link
G Kif20b kinesin family member 20B multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in increased expression of KIF20B mRNA] CTD PMID:19442820 NCBI chr 1:253,220,038...253,275,523
Ensembl chr 1:253,221,812...253,275,490
JBrowse link
G Kif2c kinesin family member 2C multiple interactions ISO caffeic acid inhibits the reaction [Thapsigargin results in increased expression of KIF2C mRNA] CTD PMID:19442820 NCBI chr 5:136,027,923...136,053,268
Ensembl chr 5:136,027,934...136,053,210
JBrowse link
G Ldha lactate dehydrogenase A multiple interactions EXP caffeic acid inhibits the reaction [Isoproterenol results in increased expression of LDHA protein] CTD PMID:21472895 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Ldhb lactate dehydrogenase B multiple interactions EXP caffeic acid inhibits the reaction [Isoproterenol results in increased expression of LDHB protein] CTD PMID:21472895 NCBI chr 4:176,701,980...176,719,999
Ensembl chr 4:176,701,983...176,720,012
JBrowse link
G Maoa monoamine oxidase A decreases activity ISO caffeic acid results in decreased activity of MAOA protein CTD PMID:27270453 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Maob monoamine oxidase B decreases activity ISO caffeic acid results in decreased activity of MAOB protein CTD PMID:27270453 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 multiple interactions ISO [Thapsigargin co-treated with caffeic acid] results in decreased expression of MAP2K5 mRNA CTD PMID:19442820 NCBI chr 8:68,055,976...68,282,656
Ensembl chr 8:68,055,972...68,282,590
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO caffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK1 protein] CTD PMID:27720869 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO caffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK3 protein] CTD PMID:27720869 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mfn1 mitofusin 1 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MFN1 mRNA] CTD PMID:19442820 NCBI chr 2:118,929,738...118,971,689
Ensembl chr 2:118,929,738...118,973,698
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases activity EXP caffeic acid results in increased activity of MGST1 protein CTD PMID:16125204 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity
ISO caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [MPO protein results in increased metabolism of Hydrogen Peroxide]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MPO protein]
caffeic acid results in decreased activity of MPO protein
CTD PMID:22036979, PMID:24060682 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mrpl45 mitochondrial ribosomal protein L45 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MRPL45 mRNA] CTD PMID:19442820 NCBI chr10:85,257,876...85,269,806
Ensembl chr10:85,257,876...85,269,806
JBrowse link
G Mrrf mitochondrial ribosome recycling factor multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MRRF mRNA] CTD PMID:19442820 NCBI chr 3:15,463,884...15,520,621
Ensembl chr 3:15,463,953...15,520,618
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II multiple interactions ISO [caffeic acid co-treated with Zymosan] results in increased expression of COX2 protein; caffeic acid inhibits the reaction [Zymosan results in increased expression of COX2 protein] CTD PMID:30481570 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Ndp norrin cystine knot growth factor NDP increases expression ISO caffeic acid results in increased expression of NDP mRNA CTD PMID:19442820 NCBI chr  X:6,791,090...6,815,586
Ensembl chr  X:6,791,136...6,815,583
Ensembl chr  X:6,791,136...6,815,583
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO
caffeic acid inhibits the reaction [Valproic Acid results in increased expression of NOS2 protein]
caffeic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD PMID:29968957, PMID:31306686 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO caffeic acid results in increased expression of NOS3 mRNA CTD PMID:15740983 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Notch1 notch receptor 1 multiple interactions EXP caffeic acid inhibits the reaction [Valproic Acid results in increased expression of NOTCH1 mRNA] CTD PMID:29968957 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Nt5e 5' nucleotidase, ecto multiple interactions
decreases activity
EXP caffeic acid inhibits the reaction [Caffeine results in decreased activity of NT5E protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of NT5E protein] CTD PMID:28465162 NCBI chr 8:95,969,002...96,012,733
Ensembl chr 8:95,968,652...96,012,696
JBrowse link
G Pdcd10 programmed cell death 10 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PDCD10 mRNA] CTD PMID:19442820 NCBI chr 2:173,966,701...174,012,730
Ensembl chr 2:173,967,080...174,012,676
JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity ISO caffeic acid results in decreased activity of PGD protein CTD PMID:25130191 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression ISO caffeic acid results in increased expression of PIK3R1 mRNA CTD PMID:21870829 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Plk1 polo-like kinase 1 multiple interactions ISO [Thapsigargin co-treated with caffeic acid] results in increased expression of PLK1 mRNA CTD PMID:19442820 NCBI chr 1:192,115,990...192,125,969
Ensembl chr 1:192,115,966...192,125,989
JBrowse link
G Plk4 polo-like kinase 4 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in increased expression of PLK4 mRNA] CTD PMID:19442820 NCBI chr 2:127,686,911...127,705,518
Ensembl chr 2:127,686,925...127,705,518
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO caffeic acid results in increased expression of PPARG mRNA CTD PMID:21870829 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prdx5 peroxiredoxin 5 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PRDX5 mRNA] CTD PMID:19442820 NCBI chr 1:222,164,462...222,167,447
Ensembl chr 1:222,164,462...222,167,447
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO caffeic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PTGS2 mRNA]
CTD PMID:19442820, PMID:22036979, PMID:31306686 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptx3 pentraxin 3 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PTX3 mRNA] CTD PMID:19442820 NCBI chr 2:158,097,843...158,103,653
Ensembl chr 2:158,097,843...158,103,653
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO caffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of RAF1 protein] CTD PMID:27720869 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP caffeic acid inhibits the reaction [Valproic Acid results in increased expression of RELA protein] CTD PMID:29968957 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO [Metformin co-treated with caffeic acid] results in decreased expression of SCD1 protein CTD PMID:28576465 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO caffeic acid inhibits the reaction [Acetaminophen results in increased expression of SERPINE1 protein] CTD PMID:27720869 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sfxn4 sideroflexin 4 multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in decreased expression of SFXN4 mRNA] CTD PMID:19442820 NCBI chr 1:282,213,610...282,236,851
Ensembl chr 1:282,213,675...282,235,974
JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO caffeic acid results in increased expression of SLC2A4 mRNA CTD PMID:21870829 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Snca synuclein alpha multiple interactions ISO caffeic acid inhibits the reaction [SNCA protein binds to SNCA protein] CTD PMID:20150427 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO [Metformin co-treated with caffeic acid] results in decreased expression of SREBF1 protein CTD PMID:28576465 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Stk32a serine/threonine kinase 32A multiple interactions ISO [Thapsigargin co-treated with caffeic acid] results in decreased expression of STK32A mRNA CTD PMID:19442820 NCBI chr18:37,597,305...37,706,884
Ensembl chr18:37,597,156...37,710,306
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO SULT1A1 protein results in increased sulfation of caffeic acid CTD PMID:17433394 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Sult1c2a sulfotransferase family, cytosolic, 1C, member 2a increases sulfation ISO SULT1C2 protein results in increased sulfation of caffeic acid CTD PMID:17433394 NCBI chr 9:4,152,588...4,168,355
Ensembl chr 9:4,152,589...4,168,221
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
caffeic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]
caffeic acid inhibits the reaction [Aluminum results in increased expression of TNF protein]; caffeic acid inhibits the reaction [Valproic Acid results in increased expression of TNF protein]
caffeic acid results in increased expression of TNF mRNA
CTD PMID:21870829, PMID:22036979, PMID:27368151, PMID:29968957, PMID:31306686 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 affects expression
multiple interactions
ISO caffeic acid affects the expression of TP53 protein
caffeic acid promotes the reaction [Thapsigargin results in decreased expression of TP53 mRNA]
CTD PMID:11522280, PMID:19442820 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tyr tyrosinase increases oxidation
multiple interactions
ISO TYR protein results in increased oxidation of caffeic acid
[TYR protein results in increased oxidation of caffeic acid] which results in decreased abundance of Glutathione
CTD PMID:20685355 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C multiple interactions ISO caffeic acid promotes the reaction [Thapsigargin results in increased expression of UBE2C mRNA] CTD PMID:19442820 NCBI chr 3:161,236,971...161,239,371
Ensembl chr 3:161,236,898...161,241,159
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of caffeic acid CTD PMID:15117964 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of caffeic acid CTD PMID:15117964 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vegfa vascular endothelial growth factor A decreases secretion ISO caffeic acid results in decreased secretion of VEGFA protein CTD PMID:27378625 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein] CTD PMID:22036979 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
acteoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
decreases localization
ISO acteoside promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased localization of AHR protein]
acteoside results in decreased localization of AHR protein
CTD PMID:21756928 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator increases localization ISO acteoside results in increased localization of ARNT protein CTD PMID:21756928 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions
decreases secretion
ISO acteoside results in decreased expression of CCL2 mRNA
acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]
acteoside results in decreased secretion of CCL2 protein
CTD PMID:21756928, PMID:21967610 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO acteoside results in decreased expression of CCND1 protein CTD PMID:17634406 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO acteoside results in decreased expression of CCND2 protein CTD PMID:17634406 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO acteoside results in decreased expression of CCND3 protein CTD PMID:17634406 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO acteoside results in decreased expression of CCNE1 protein CTD PMID:17634406 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO acteoside results in decreased expression of and results in decreased activity of CDK2 protein CTD PMID:17634406 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases activity
multiple interactions
ISO acteoside results in decreased activity of CDK4 protein
acteoside promotes the reaction [CDKN1A protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK4 protein]
CTD PMID:17634406 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions ISO acteoside promotes the reaction [CDKN1A protein binds to CDK6 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK6 protein]; acteoside results in decreased expression of and results in decreased activity of CDK6 protein CTD PMID:17634406 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO acteoside results in increased expression of CDKN1A mRNA; acteoside results in increased expression of CDKN1A protein
acteoside promotes the reaction [CDKN1A protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1A protein binds to CDK6 protein]
CTD PMID:17634406 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
multiple interactions
ISO acteoside results in increased expression of CDKN1B mRNA; acteoside results in increased expression of CDKN1B protein
acteoside promotes the reaction [CDKN1B protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK6 protein]
CTD PMID:17634406 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases secretion
decreases expression
multiple interactions
ISO acteoside results in decreased secretion of CXCL10 protein
acteoside results in decreased expression of CXCL10 mRNA
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [PD168393 results in increased secretion of CXCL10 protein]; acteoside promotes the reaction [leptomycin B results in decreased secretion of CXCL10 protein]
CTD PMID:21756928, PMID:21967610 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO acteoside results in increased expression of CYP1A1 mRNA CTD PMID:21756928 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP acteoside inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CYP2E1 protein] CTD PMID:14672760 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO [acteoside results in decreased phosphorylation of RB1 protein] promotes the reaction [RB1 protein binds to E2F1 protein] CTD PMID:17634406 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Egfr epidermal growth factor receptor decreases phosphorylation
multiple interactions
ISO acteoside results in decreased phosphorylation of EGFR protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein modified form]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein]
CTD PMID:21756928, PMID:21967610 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO acteoside results in decreased expression of ICAM1 mRNA CTD PMID:21371465 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma decreases expression
multiple interactions
ISO acteoside results in decreased expression of IFNG mRNA
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]
CTD PMID:21371465, PMID:21756928 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]
acteoside results in decreased expression of IL6 mRNA
CTD PMID:21756928 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO acteoside inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]; acteoside inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB2 protein] CTD PMID:16393473 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
decreases phosphorylation
ISO acteoside results in increased phosphorylation of MAPK1 protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]
acteoside results in decreased phosphorylation of MAPK1 protein
CTD PMID:21756928, PMID:23527233 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
increases phosphorylation
ISO acteoside results in decreased phosphorylation of MAPK3 protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]
acteoside results in increased phosphorylation of MAPK3 protein
CTD PMID:21756928, PMID:23527233 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nox1 NADPH oxidase 1 decreases activity ISO acteoside results in decreased activity of NOX1 protein CTD PMID:16393473 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Ptgds prostaglandin D2 synthase affects binding ISO acteoside binds to PTGDS protein CTD PMID:26456343 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [acteoside co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PTGS2 mRNA CTD PMID:21756928 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation
multiple interactions
ISO acteoside results in decreased phosphorylation of RB1 protein
[acteoside results in decreased phosphorylation of RB1 protein] promotes the reaction [RB1 protein binds to E2F1 protein]
CTD PMID:17634406 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation
multiple interactions
decreases phosphorylation
ISO acteoside results in increased phosphorylation of RELA protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]
acteoside results in decreased phosphorylation of RELA protein
CTD PMID:21756928, PMID:23527233 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Smad2 SMAD family member 2 increases phosphorylation ISO acteoside results in increased phosphorylation of SMAD2 protein CTD PMID:17634406 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 increases phosphorylation ISO acteoside results in increased phosphorylation of SMAD3 protein CTD PMID:17634406 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO acteoside results in decreased expression of SOD2 mRNA CTD PMID:21371465 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO [acteoside co-treated with TGFA protein] results in increased expression of CXCL8 mRNA; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein modified form]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein] CTD PMID:21756928, PMID:21967610 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO acteoside results in increased expression of TGFB1 mRNA CTD PMID:17634406 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein] CTD PMID:21756928 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO acteoside results in decreased expression of VCAM1 mRNA CTD PMID:21371465 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
chlorogenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of ABCC1 protein] CTD PMID:25043994 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of ABCC2 protein] CTD PMID:25043994 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Ache acetylcholinesterase decreases activity ISO Chlorogenic Acid results in decreased activity of ACHE protein CTD PMID:20854806 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acly ATP citrate lyase increases expression ISO Chlorogenic Acid results in increased expression of ACLY mRNA CTD PMID:20706672 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:23146752 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Alb albumin multiple interactions EXP
ISO
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein]
Chlorogenic Acid affects the reaction [2,2'-azobis(2-amidinopropane) results in increased degradation of ALB protein]
CTD PMID:11322927, PMID:23146752 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aqp1 aquaporin 1 increases expression ISO Chlorogenic Acid results in increased expression of AQP1 mRNA CTD PMID:20706672 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) increases expression ISO Chlorogenic Acid results in increased expression of AQP3 mRNA CTD PMID:20706672 NCBI chr 5:57,423,735...57,429,252
Ensembl chr 5:57,423,734...57,429,245
JBrowse link
G Ar androgen receptor decreases expression ISO Chlorogenic Acid results in decreased expression of AR mRNA CTD PMID:20706672 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bambi BMP and activin membrane-bound inhibitor multiple interactions EXP Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of BAMBI mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of BAMBI protein] CTD PMID:23146752 NCBI chr17:56,905,419...56,909,675
Ensembl chr17:56,905,112...56,909,992
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP
Chlorogenic Acid inhibits the reaction [aluminum chloride results in increased expression of BAX protein]; Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of BAX protein]
Chlorogenic Acid inhibits the reaction [Methotrexate results in increased expression of BAX protein]
CTD PMID:25043994, PMID:28479099, PMID:28623112 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO
Chlorogenic Acid inhibits the reaction [Methotrexate results in decreased expression of BCL2 protein]
Chlorogenic Acid inhibits the reaction [aluminum chloride results in decreased expression of BCL2 protein]
CTD PMID:28479099, PMID:28623112 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
Chlorogenic Acid inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
Chlorogenic Acid inhibits the reaction [Methotrexate results in increased activity of CASP3 protein]
CTD PMID:25043994, PMID:28479099 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Chlorogenic Acid inhibits the reaction [aluminum chloride results in increased expression of CASP8 protein] CTD PMID:28623112 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Methotrexate results in increased activity of CASP9 protein] CTD PMID:28479099 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions EXP
ISO
Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in decreased activity of CAT protein]
Chlorogenic Acid inhibits the reaction [aluminum chloride results in decreased activity of CAT protein]
CTD PMID:28479099, PMID:28623112, PMID:31390532 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of CCL2 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] CTD PMID:26079055, PMID:31306686 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of CCND1 protein] CTD PMID:25043994 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO Chlorogenic Acid results in increased expression of CD44 mRNA CTD PMID:20706672 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdh1 cadherin 1 increases expression ISO Chlorogenic Acid results in increased expression of CDH1 mRNA CTD PMID:20706672 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression
multiple interactions
ISO
EXP
Chlorogenic Acid results in increased expression of COL1A1 mRNA
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]
CTD PMID:20706672, PMID:23146752 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Citric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of phenylacetylglycine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein] CTD PMID:24709313 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
JBrowse link
G Cs citrate synthase increases activity ISO Chlorogenic Acid results in increased activity of CS protein CTD PMID:31306686 NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of CXCL1 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of CXCL1 protein] CTD PMID:26079055 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cygb cytoglobin decreases expression ISO Chlorogenic Acid results in decreased expression of CYGB mRNA CTD PMID:20706672 NCBI chr10:105,618,325...105,628,091
Ensembl chr10:105,618,326...105,628,091
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression EXP Chlorogenic Acid results in increased expression of CYP19A1 protein CTD PMID:29899696 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of CYP2E1 protein] CTD PMID:25043994 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Dsg3 desmoglein 3 decreases expression ISO Chlorogenic Acid results in decreased expression of DSG3 mRNA CTD PMID:20706672 NCBI chr18:15,652,948...15,688,605
Ensembl chr18:15,650,526...15,688,284
JBrowse link
G Egf epidermal growth factor decreases expression ISO Chlorogenic Acid results in decreased expression of EGF mRNA CTD PMID:20706672 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Esr1 estrogen receptor 1 decreases expression EXP Chlorogenic Acid results in decreased expression of ESR1 protein CTD PMID:29899696 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 increases expression EXP Chlorogenic Acid results in increased expression of ESR2 protein CTD PMID:29899696 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G F10 coagulation factor X decreases activity ISO Chlorogenic Acid results in decreased activity of F10 protein CTD PMID:27704645 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716
JBrowse link
G F2 coagulation factor II decreases activity ISO Chlorogenic Acid results in decreased activity of F2 protein CTD PMID:27704645 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G Fasn fatty acid synthase decreases expression ISO Chlorogenic Acid results in decreased expression of FASN mRNA CTD PMID:21870829 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fbn1 fibrillin 1 decreases expression ISO Chlorogenic Acid results in decreased expression of FBN1 mRNA CTD PMID:20706672 NCBI chr 3:117,569,708...117,766,160
Ensembl chr 3:117,569,697...117,766,120
JBrowse link
G Fbn2 fibrillin 2 decreases expression ISO Chlorogenic Acid results in decreased expression of FBN2 mRNA CTD PMID:20706672 NCBI chr18:53,068,495...53,272,254
Ensembl chr18:53,068,495...53,181,503
JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression ISO Chlorogenic Acid results in increased expression of FGF1 mRNA CTD PMID:20706672 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fshr follicle stimulating hormone receptor increases expression EXP Chlorogenic Acid results in increased expression of FSHR protein CTD PMID:29899696 NCBI chr 6:12,796,383...12,997,817
Ensembl chr 6:12,796,383...12,997,817
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO Chlorogenic Acid results in increased expression of GCLC mRNA
Chlorogenic Acid promotes the reaction [Acetaminophen results in increased expression of GCLC mRNA]
CTD PMID:29136249 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Chlorogenic Acid results in increased expression of GCLM mRNA CTD PMID:29136249 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO
Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased activity of GPT protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in increased activity of GPT protein]
Chlorogenic Acid inhibits the reaction [aluminum chloride results in increased activity of GPT protein]
CTD PMID:28479099, PMID:28623112, PMID:31390532 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Grn granulin precursor increases expression ISO Chlorogenic Acid results in increased expression of GRN mRNA CTD PMID:20706672 NCBI chr10:90,377,103...90,383,207
Ensembl chr10:90,376,933...90,383,205
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Chlorogenic Acid inhibits the reaction [Methotrexate results in decreased activity of GSR protein] CTD PMID:28479099 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases activity ISO Chlorogenic Acid results in increased activity of GSTA1 protein CTD PMID:15944151 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Has1 hyaluronan synthase 1 increases expression ISO Chlorogenic Acid results in increased expression of HAS1 mRNA CTD PMID:20706672 NCBI chr 1:59,720,612...59,732,409
Ensembl chr 1:59,720,612...59,732,409
JBrowse link
G Hlcs holocarboxylase synthetase decreases activity ISO Chlorogenic Acid results in decreased activity of HLCS protein CTD PMID:26303405 NCBI chr11:34,357,372...34,537,798
Ensembl chr11:34,352,287...34,526,931
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
decreases expression
EXP
ISO
[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]; Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]
Chlorogenic Acid results in decreased expression of HMGCR mRNA
CTD PMID:20696151, PMID:21870829 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of HMOX1 protein]
Chlorogenic Acid results in increased expression of HMOX1 mRNA
Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 protein]
CTD PMID:25043994, PMID:29136249 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO Chlorogenic Acid results in increased expression of HSPB1 mRNA CTD PMID:20706672 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO Chlorogenic Acid results in decreased expression of IL1A mRNA CTD PMID:20706672 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO
[geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of IL1B protein]
CTD PMID:23146752, PMID:24709313, PMID:26079055 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO
EXP
Chlorogenic Acid results in increased expression of IL6 mRNA
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of IL6 protein]
Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL6 protein]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]
CTD PMID:21870829, PMID:23146752, PMID:26079055, PMID:31390532 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgb2 integrin subunit beta 2 decreases expression
multiple interactions
EXP Chlorogenic Acid results in decreased expression of ITGB2 protein
Chlorogenic Acid inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of ITGB2 protein]
CTD PMID:21414398 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of JUN protein] CTD PMID:15944151 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Krt5 keratin 5 increases expression ISO Chlorogenic Acid results in increased expression of KRT5 mRNA CTD PMID:20706672 NCBI chr 7:143,320,142...143,324,536
Ensembl chr 7:143,316,920...143,453,546
JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions EXP [tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]; Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein] CTD PMID:20696151 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813
JBrowse link
G Lpl lipoprotein lipase multiple interactions EXP [tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein]; Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein] CTD PMID:20696151 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Maoa monoamine oxidase A decreases activity ISO Chlorogenic Acid results in decreased activity of MAOA protein CTD PMID:27270453 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Maob monoamine oxidase B decreases activity ISO Chlorogenic Acid results in decreased activity of MAOB protein CTD PMID:27270453 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAP2K4 protein] CTD PMID:15944151 NCBI chr10:52,196,121...52,301,887
Ensembl chr10:52,196,124...52,290,657
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
Chlorogenic Acid promotes the reaction [Acetaminophen results in increased phosphorylation of MAPK1 protein]
CTD PMID:15944151, PMID:29136249 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK14 protein] CTD PMID:15944151 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
Chlorogenic Acid promotes the reaction [Acetaminophen results in increased phosphorylation of MAPK3 protein]
CTD PMID:15944151, PMID:29136249 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mc1r melanocortin 1 receptor increases expression ISO Chlorogenic Acid results in increased expression of MC1R mRNA CTD PMID:20706672 NCBI chr19:56,215,420...56,219,987 JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases activity EXP Chlorogenic Acid results in decreased activity of MGST1 protein CTD PMID:16125204 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of MPO protein] CTD PMID:26079055 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I increases expression ISO Chlorogenic Acid results in increased expression of COX1 mRNA CTD PMID:20706672 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II multiple interactions ISO [Chlorogenic Acid co-treated with Zymosan] results in decreased expression of COX2 protein; Chlorogenic Acid inhibits the reaction [Zymosan results in increased expression of COX2 protein] CTD PMID:30481570 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MT1 mRNA]; Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MT1 protein] CTD PMID:31390532 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP
ISO
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of MYD88 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of MYD88 protein]
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of MYD88 protein]
CTD PMID:23146752, PMID:26079055 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases localization
multiple interactions
increases response to substance
affects localization
decreases response to substance
ISO Chlorogenic Acid results in increased localization of NFE2L2 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Chlorogenic Acid co-treated with Acetaminophen] results in increased phosphorylation of and affects the localization of and results in increased activity of NFE2L2 protein]; [Chlorogenic Acid co-treated with Acetaminophen] results in increased activity of and affects the localization of NFE2L2 protein; [Chlorogenic Acid co-treated with Acetaminophen] results in increased phosphorylation of and affects the localization of and results in increased activity of NFE2L2 protein; U 0126 inhibits the reaction [[Chlorogenic Acid co-treated with Acetaminophen] results in increased phosphorylation of and affects the localization of and results in increased activity of NFE2L2 protein]
[Chlorogenic Acid co-treated with Acetaminophen] affects the localization of and results in increased activity of NFE2L2 protein
NFE2L2 results in increased susceptibility to Chlorogenic Acid
Chlorogenic Acid affects the localization of NFE2L2 protein
NFE2L2 gene mutant form results in decreased susceptibility to Chlorogenic Acid
CTD PMID:15944151, PMID:29136249 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO
EXP
Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of and results in increased phosphorylation of NFKBIA protein]
CTD PMID:20026373, PMID:23146752 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions ISO Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of NFKBIB protein] CTD PMID:20026373 NCBI chr 1:86,941,073...86,948,845
Ensembl chr 1:86,941,074...86,948,845
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Chlorogenic Acid inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein]
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in increased expression of NOS2 protein]
CTD PMID:20026373, PMID:23146752, PMID:28479099, PMID:31306686 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO Chlorogenic Acid results in increased expression of NOS3 mRNA CTD PMID:20706672 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression
multiple interactions
ISO Chlorogenic Acid results in increased activity of NQO1 protein
Chlorogenic Acid results in increased expression of NQO1 mRNA
Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of NQO1 mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of NQO1 protein]
CTD PMID:15944151, PMID:29136249 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Ocln occludin multiple interactions EXP Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of OCLN mRNA]; Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of OCLN protein] CTD PMID:31390532 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Chlorogenic Acid promotes the reaction [Cisplatin results in increased expression of PCNA protein] CTD PMID:25043994 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions EXP Chlorogenic Acid inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PECAM1 protein] CTD PMID:21414398 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Pgr progesterone receptor increases expression
decreases expression
ISO Chlorogenic Acid results in increased expression of PGR mRNA
Chlorogenic Acid results in decreased expression of PGR mRNA
CTD PMID:20706672 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression ISO Chlorogenic Acid results in increased expression of PIK3R1 mRNA CTD PMID:21870829 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 increases expression ISO Chlorogenic Acid results in increased expression of PLOD3 mRNA CTD PMID:20706672 NCBI chr12:22,716,421...22,726,982
Ensembl chr12:22,716,423...22,726,982
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
decreases expression
ISO Chlorogenic Acid results in increased expression of PPARG mRNA
Chlorogenic Acid results in decreased expression of PPARG mRNA
CTD PMID:20706672, PMID:21870829 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha multiple interactions ISO [Chlorogenic Acid co-treated with Acetaminophen] results in decreased expression of PPP2R1A protein CTD PMID:29136249 NCBI chr 1:60,717,386...60,736,629
Ensembl chr 1:60,717,386...60,736,609
JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit multiple interactions ISO [Chlorogenic Acid co-treated with Acetaminophen] results in decreased expression of PPP5C protein CTD PMID:29136249 NCBI chr 1:78,944,054...78,968,361
Ensembl chr 1:78,944,040...78,968,329
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; Chlorogenic Acid inhibits the reaction [Methotrexate results in increased expression of PTGS2 protein]
Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of and results in increased expression of PTGS2 protein]
CTD PMID:20026373, PMID:23146752, PMID:25043994, PMID:28479099, PMID:31306686 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein decreases expression ISO Chlorogenic Acid results in decreased expression of RAD23A mRNA CTD PMID:20706672 NCBI chr19:25,949,488...25,956,677
Ensembl chr19:25,949,490...25,955,391
JBrowse link
G Rara retinoic acid receptor, alpha increases expression ISO Chlorogenic Acid results in increased expression of RARA mRNA CTD PMID:20706672 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of and results in increased phosphorylation of and affects the localization of RELA protein]; Chlorogenic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein] CTD PMID:20026373, PMID:26079055 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rxra retinoid X receptor alpha decreases expression ISO Chlorogenic Acid results in decreased expression of RXRA mRNA CTD PMID:20706672 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Sell selectin L multiple interactions EXP [Chlorogenic Acid co-treated with lipopolysaccharide, E. coli O26-B6] results in increased expression of SELL protein; Chlorogenic Acid inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased expression of SELL protein] CTD PMID:21414398 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions EXP Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC11A2 mRNA]; Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC11A2 protein] CTD PMID:31390532 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in decreased expression of SLC22A2 protein] CTD PMID:25043994 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO Chlorogenic Acid results in increased expression of SLC2A4 mRNA CTD PMID:21870829 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Sod3 superoxide dismutase 3 decreases expression ISO Chlorogenic Acid results in decreased expression of SOD3 mRNA CTD PMID:20706672 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Acetaminophen results in decreased expression of SQSTM1 protein] CTD PMID:29136249 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases expression ISO Chlorogenic Acid results in decreased expression of SRD5A2 mRNA CTD PMID:20706672 NCBI chr 6:25,279,635...25,315,501
Ensembl chr 6:25,279,626...25,315,511
JBrowse link
G Star steroidogenic acute regulatory protein increases expression EXP Chlorogenic Acid results in increased expression of STAR protein CTD PMID:29899696 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions EXP Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TJP1 mRNA]; Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TJP1 protein] CTD PMID:31390532 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of TLR3 protein] CTD PMID:26079055 NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP
ISO
Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 mRNA]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 protein]
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of TLR4 protein]
CTD PMID:23146752, PMID:26079055 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO
EXP
Chlorogenic Acid results in increased expression of TNF mRNA
Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased secretion of TNF protein]; Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF protein]; Chlorogenic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]
CTD PMID:21870829, PMID:23146752, PMID:25043994, PMID:26079055, PMID:31306686, PMID:31390532 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of TRP53 protein] CTD PMID:25043994 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 increases expression ISO Chlorogenic Acid results in increased expression of TPT1 mRNA CTD PMID:20706672 NCBI chr15:57,891,680...57,894,504
Ensembl chr15:57,891,680...57,894,504
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO Chlorogenic Acid results in increased expression of TXN mRNA CTD PMID:20706672 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Tyr tyrosinase increases oxidation
multiple interactions
ISO TYR protein results in increased oxidation of Chlorogenic Acid
[TYR protein results in increased oxidation of Chlorogenic Acid] which results in decreased abundance of Glutathione
CTD PMID:20685355 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Tyrp1 tyrosinase-related protein 1 decreases expression ISO Chlorogenic Acid results in decreased expression of TYRP1 mRNA CTD PMID:20706672 NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Chlorogenic Acid CTD PMID:15117964 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Chlorogenic Acid CTD PMID:15117964 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
ethyl trans-caffeate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO ethyl caffeate affects the phosphorylation of and affects the activity of AKT1 protein CTD PMID:24892518 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Cdh2 cadherin 2 affects expression ISO ethyl caffeate affects the expression of CDH2 protein CTD PMID:24892518 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdk2 cyclin dependent kinase 2 affects expression ISO ethyl caffeate affects the expression of CDK2 protein CTD PMID:24892518 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 affects expression ISO ethyl caffeate affects the expression of CDK4 protein CTD PMID:24892518 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 affects expression
multiple interactions
ISO ethyl caffeate affects the expression of ERBB2 protein
ethyl caffeate affects the phosphorylation of and affects the activity of ERBB2 protein
CTD PMID:24892518 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 affects expression ISO ethyl caffeate affects the expression of FGFR1 protein CTD PMID:24892518 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Ilk integrin-linked kinase affects expression ISO ethyl caffeate affects the expression of ILK protein CTD PMID:24892518 NCBI chr 1:170,578,941...170,585,192
Ensembl chr 1:170,578,889...170,585,189
JBrowse link
G Itga3 integrin subunit alpha 3 multiple interactions ISO ethyl caffeate affects the expression of [ITGA3 protein binds to ITGB1 protein] CTD PMID:24892518 NCBI chr10:82,855,841...82,887,755
Ensembl chr10:82,855,613...82,887,497
JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions ISO ethyl caffeate affects the expression of [ITGA3 protein binds to ITGB1 protein] CTD PMID:24892518 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Kdr kinase insert domain receptor affects expression ISO ethyl caffeate affects the expression of KDR protein CTD PMID:24892518 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO ethyl caffeate affects the phosphorylation of and affects the activity of MAPK1 protein CTD PMID:24892518 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO ethyl caffeate affects the phosphorylation of and affects the activity of MAPK3 protein CTD PMID:24892518 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Rb1 RB transcriptional corepressor 1 affects phosphorylation ISO ethyl caffeate affects the phosphorylation of RB1 protein CTD PMID:24892518 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
rosmarinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions
EXP rosmarinic acid results in decreased expression of ACTA2 protein
rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
CTD PMID:28789951 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 multiple interactions
decreases expression
ISO [rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which affects the localization of PROCR protein; [rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which results in decreased cleavage of and results in decreased secretion of PROCR protein; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein results in increased cleavage of and results in increased secretion of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein]; rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein] CTD PMID:23774263 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO rosmarinic acid inhibits the reaction [Cadmium affects the localization of AIFM1 protein] CTD PMID:23548128 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
rosmarinic acid inhibits the reaction [Cadmium results in increased activity of CASP3 protein]
rosmarinic acid inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]
CTD PMID:23548128, PMID:28815802 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions
increases activity
increases expression
ISO rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased activity of CAT protein]; rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of CAT mRNA]
rosmarinic acid results in increased activity of CAT protein
rosmarinic acid results in increased expression of CAT mRNA
CTD PMID:31610155 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions
decreases expression
EXP rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]
rosmarinic acid results in decreased expression of CCN2 mRNA
CTD PMID:28789951 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein] CTD PMID:28789951 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd68 Cd68 molecule decreases expression EXP rosmarinic acid results in decreased expression of CD68 protein CTD PMID:28789951 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression
multiple interactions
ISO
EXP
rosmarinic acid results in decreased expression of COL1A1 mRNA
rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]
CTD PMID:27235791, PMID:28789951 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions
decreases expression
EXP rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]
rosmarinic acid results in decreased expression of COL3A1 mRNA
CTD PMID:28789951 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Crp C-reactive protein affects expression
multiple interactions
EXP rosmarinic acid affects the expression of CRP protein
2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of CRP protein]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of CRP protein]
CTD PMID:28744220 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions
decreases expression
ISO rosmarinic acid inhibits the reaction [Particulate Matter results in increased expression of CXCL1 protein]; rosmarinic acid inhibits the reaction [Vehicle Emissions results in increased expression of CXCL1 protein]
rosmarinic acid results in decreased expression of CXCL1 mRNA
CTD PMID:12684091, PMID:26804033 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Des desmin multiple interactions EXP rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of DES protein] CTD PMID:28789951 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression ISO rosmarinic acid results in decreased expression of DNMT1 protein CTD PMID:21078381 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Fn1 fibronectin 1 decreases expression ISO rosmarinic acid results in decreased expression of FN1 mRNA CTD PMID:26804033 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression EXP rosmarinic acid results in decreased expression of FOS protein CTD PMID:28789951 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gpt glutamic--pyruvic transaminase decreases activity EXP rosmarinic acid results in decreased activity of GPT protein CTD PMID:25455894 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases expression
ISO rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GPX1 mRNA]
rosmarinic acid results in increased expression of GPX1 mRNA
CTD PMID:31610155 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gsto1 glutathione S-transferase omega 1 increases expression
multiple interactions
ISO rosmarinic acid results in increased expression of GSTO1 mRNA
rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GSTO1 mRNA]
CTD PMID:31610155 NCBI chr 1:267,607,437...267,617,387
Ensembl chr 1:267,607,418...267,617,387
JBrowse link
G Hmgb1 high mobility group box 1 decreases expression EXP rosmarinic acid results in decreased expression of HMGB1 protein CTD PMID:28789951 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO rosmarinic acid results in increased expression of HMOX1 mRNA
rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of HMOX1 mRNA]
CTD PMID:31610155 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO
EXP
[rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein results in increased cleavage of and results in increased secretion of PROCR protein]
rosmarinic acid results in decreased expression of IL1B mRNA; rosmarinic acid results in decreased expression of IL1B protein
rosmarinic acid inhibits the reaction [Cadmium results in increased expression of IL1B protein]; rosmarinic acid inhibits the reaction [Particulate Matter results in increased expression of IL1B protein]; rosmarinic acid inhibits the reaction [Vehicle Emissions results in increased expression of IL1B protein]
CTD PMID:12684091, PMID:23548128, PMID:23774263, PMID:25455894, PMID:28789951 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
affects expression
increases expression
ISO
EXP
rosmarinic acid inhibits the reaction [Cadmium results in increased expression of IL6 protein]
rosmarinic acid results in decreased expression of IL6 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of IL6 protein]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of IL6 protein]
rosmarinic acid results in increased expression of IL6 mRNA
rosmarinic acid results in decreased expression of IL6 mRNA
CTD PMID:23548128, PMID:26804033, PMID:28744220, PMID:28789951 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases phosphorylation EXP rosmarinic acid results in decreased phosphorylation of JUN protein CTD PMID:28789951 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kcnu1 potassium calcium-activated channel subfamily U member 1 decreases activity ISO rosmarinic acid results in decreased activity of KCNU1 protein CTD PMID:30009954 NCBI chr16:70,913,825...70,998,593
Ensembl chr16:70,913,817...70,998,575
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions
decreases expression
ISO rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 protein]
rosmarinic acid results in decreased expression of KEAP1 protein
CTD PMID:31610155 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Maoa monoamine oxidase A decreases activity ISO rosmarinic acid results in decreased activity of MAOA protein CTD PMID:27270453 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Maob monoamine oxidase B decreases activity ISO rosmarinic acid results in decreased activity of MAOB protein CTD PMID:27270453 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 decreases phosphorylation EXP rosmarinic acid results in decreased phosphorylation of MAP3K7 protein CTD PMID:28789951 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation EXP rosmarinic acid results in decreased phosphorylation of MAPK1 protein CTD PMID:28789951 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation EXP rosmarinic acid results in decreased phosphorylation of MAPK3 protein CTD PMID:28789951 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases phosphorylation EXP rosmarinic acid results in decreased phosphorylation of MAPK8 protein CTD PMID:28789951 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases phosphorylation EXP rosmarinic acid results in decreased phosphorylation of MAPK9 protein CTD PMID:28789951 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression EXP rosmarinic acid results in decreased expression of MMP2 mRNA; rosmarinic acid results in decreased expression of MMP2 protein CTD PMID:28789951 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression EXP rosmarinic acid results in decreased expression of MMP9 mRNA; rosmarinic acid results in decreased expression of MMP9 protein CTD PMID:28789951 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase decreases expression EXP rosmarinic acid results in decreased expression of MPO protein CTD PMID:28789951 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor decreases expression EXP rosmarinic acid results in decreased expression of MYD88 protein CTD PMID:28789951 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
ISO [lead acetate results in increased abundance of Lead] inhibits the reaction [rosmarinic acid results in increased expression of NFE2L2 protein]; rosmarinic acid affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 mRNA]
rosmarinic acid results in increased expression of NFE2L2 mRNA; rosmarinic acid results in increased expression of NFE2L2 protein
CTD PMID:31610155 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
EXP rosmarinic acid results in decreased expression of NOS2 protein
rosmarinic acid inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]
CTD PMID:25455894, PMID:28815802 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression EXP rosmarinic acid results in decreased expression of NOS3 protein CTD PMID:25455894 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO rosmarinic acid results in increased expression of NQO1 mRNA
rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of NQO1 mRNA]
CTD PMID:31610155 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase increases expression EXP rosmarinic acid results in increased expression of OGG1 mRNA CTD PMID:18996367 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Parg poly (ADP-ribose) glycohydrolase decreases activity ISO rosmarinic acid results in decreased activity of PARG protein CTD PMID:19840838 NCBI chr16:8,350,168...8,457,999
Ensembl chr16:8,350,326...8,457,996
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression
multiple interactions
EXP rosmarinic acid affects the expression of PPARG mRNA; rosmarinic acid affects the expression of PPARG protein
2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of PPARG mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of PPARG protein]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of PPARG mRNA]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of PPARG protein]
CTD PMID:28744220 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Procr protein C receptor multiple interactions
affects localization
ISO [rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which affects the localization of PROCR protein; [rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which results in decreased cleavage of and results in decreased secretion of PROCR protein; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein results in increased cleavage of and results in increased secretion of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein]; rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PROCR protein]; rosmarinic acid results in decreased cleavage of and results in decreased secretion of PROCR protein
rosmarinic acid affects the localization of PROCR protein
CTD PMID:23774263 NCBI chr 3:151,285,321...151,289,581
Ensembl chr 3:151,285,249...151,289,595
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
decreases phosphorylation
affects expression
multiple interactions
EXP rosmarinic acid affects the localization of RELA protein
rosmarinic acid results in decreased phosphorylation of RELA protein
rosmarinic acid affects the expression of RELA mRNA; rosmarinic acid affects the expression of RELA protein
2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of RELA mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of RELA protein]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of RELA mRNA]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of RELA protein]
CTD PMID:25455894, PMID:28744220, PMID:28789951 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Serpine1 serpin family E member 1 decreases expression ISO rosmarinic acid results in decreased expression of SERPINE1 mRNA CTD PMID:26804033 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sod1 superoxide dismutase 1 increases expression
multiple interactions
ISO rosmarinic acid results in increased expression of SOD1 mRNA
rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SOD1 mRNA]
CTD PMID:31610155 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions
ISO rosmarinic acid results in increased expression of SOD2 mRNA
rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SOD2 mRNA]
CTD PMID:31610155 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
EXP rosmarinic acid results in decreased expression of TGFB1 protein
rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of DES protein]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]
CTD PMID:28789951 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tlr4 toll-like receptor 4 decreases expression EXP rosmarinic acid results in decreased expression of TLR4 protein CTD PMID:28789951 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects expression
decreases expression
ISO
EXP
[rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of TNF protein]; rosmarinic acid inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of TNF protein]
rosmarinic acid results in decreased expression of TNF mRNA; rosmarinic acid results in decreased expression of TNF protein
CTD PMID:23774263, PMID:25455894, PMID:28744220, PMID:28789951, PMID:28815802 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vim vimentin multiple interactions EXP rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] CTD PMID:28789951 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      chemical role 19248
        antioxidant 14209
          caffeic acid 549
            trans-caffeic acid 244
              (2S,3R)-trans-caftaric acid 0
              1,3,4,5-tetracaffeoylquinic acid 0
              1,3-dicaffeoylquinic acid 0
              1-O-caffeoylquinic acid 0
              1-caffeoyl-5-feruloylquinic acid 0
              1-caffeoyl-beta-D-glucose 0
              2-O-caffeoyl maslinic acid 0
              3,4-dihydroxy-5-prenylcinnamic acid 0
              3,5-di-O-caffeoyl quinic acid + 0
              3-O-beta-D-glucosyl-trans-caffeic acid 0
              4-O-beta-D-glucosyl-trans-caffeic acid 0
              4-O-trans-caffeoylquinic acid + 0
              5-[(E)-caffeoyl]shikimic acid 0
              7-O-[6-(6-methoxycaffeoyl)glucosyl]isovitexin 0
              Cuscuta propenamide 1 0
              N-caffeoylspermidine 0
              acteoside 35
              caffeic acid 3-sulfate 0
              caffeic acid 3-sulfate(2-) 0
              caffeoylglycolic acid methyl ester 0
              calabricoside B 0
              chlorogenic acid 108
              ethyl trans-caffeate 13
              evolvoid A 0
              gelsemiol-6'-trans-caffeoyl-1-glucoside 0
              litseaefoloside C 0
              malvidin 3-O-\ 0
              methyl 3,4-dicaffeoylquinate 0
              quercetin 3-O-[(6-O-caffeoyl-beta-D-glucosyl)-(1->2)-beta-D-glucoside] 0
              quercetin 3-O-alpha-(6'''-caffeoylglucosyl-beta-1,2-rhamnoside) 0
              rosmarinic acid + 53
              subulatin 0
              trans-5-O-caffeoyl-D-quinic acid 0
              trans-caffeoyl-CoA 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        monocarboxylic acid 17406
                                          alpha,beta-unsaturated monocarboxylic acid 11359
                                            cinnamic acids 2375
                                              hydroxycinnamic acid 1252
                                                caffeic acid 549
                                                  trans-caffeic acid 244
                                                    (2S,3R)-trans-caftaric acid 0
                                                    1,3,4,5-tetracaffeoylquinic acid 0
                                                    1,3-dicaffeoylquinic acid 0
                                                    1-O-caffeoylquinic acid 0
                                                    1-caffeoyl-5-feruloylquinic acid 0
                                                    1-caffeoyl-beta-D-glucose 0
                                                    2-O-caffeoyl maslinic acid 0
                                                    3,4-dihydroxy-5-prenylcinnamic acid 0
                                                    3,5-di-O-caffeoyl quinic acid + 0
                                                    3-O-beta-D-glucosyl-trans-caffeic acid 0
                                                    4-O-beta-D-glucosyl-trans-caffeic acid 0
                                                    4-O-trans-caffeoylquinic acid + 0
                                                    5-[(E)-caffeoyl]shikimic acid 0
                                                    7-O-[6-(6-methoxycaffeoyl)glucosyl]isovitexin 0
                                                    Cuscuta propenamide 1 0
                                                    N-caffeoylspermidine 0
                                                    acteoside 35
                                                    caffeic acid 3-sulfate 0
                                                    caffeic acid 3-sulfate(2-) 0
                                                    caffeoylglycolic acid methyl ester 0
                                                    calabricoside B 0
                                                    chlorogenic acid 108
                                                    ethyl trans-caffeate 13
                                                    evolvoid A 0
                                                    gelsemiol-6'-trans-caffeoyl-1-glucoside 0
                                                    litseaefoloside C 0
                                                    malvidin 3-O-\ 0
                                                    methyl 3,4-dicaffeoylquinate 0
                                                    quercetin 3-O-[(6-O-caffeoyl-beta-D-glucosyl)-(1->2)-beta-D-glucoside] 0
                                                    quercetin 3-O-alpha-(6'''-caffeoylglucosyl-beta-1,2-rhamnoside) 0
                                                    rosmarinic acid + 53
                                                    subulatin 0
                                                    trans-5-O-caffeoyl-D-quinic acid 0
                                                    trans-caffeoyl-CoA 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.