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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gossypetin
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Accession:CHEBI:16400 term browser browse the term
Definition:A hexahydroxyflavone having the hydroxy groups placed at the 3-, 3'-, 4'-, 5- 7- and 8-positions.
Synonyms:exact_synonym: 2-(3,4-dihydroxyphenyl)-3,5,7,8-tetrahydroxy-4H-chromen-4-one
 related_synonym: 3,3',4',5,7,8-Hexahydroxyflavone;   Articulatidin;   Equisporol;   Formula=C15H10O8;   InChI=1S/C15H10O8/c16-6-2-1-5(3-7(6)17)14-13(22)12(21)10-8(18)4-9(19)11(20)15(10)23-14/h1-4,16-20,22H;   InChIKey=YRRAGUMVDQQZIY-UHFFFAOYSA-N;   SMILES=Oc1ccc(cc1O)-c1oc2c(O)c(O)cc(O)c2c(=O)c1O
 alt_id: CHEBI:11682;   CHEBI:1362;   CHEBI:19860;   CHEBI:38341
 xref: Beilstein:332194;   CAS:489-35-0;   KEGG:C04109;   KNApSAcK:C00004721;   LINCS:LSM-36971;   LIPID_MAPS_instance:LMPK12113231
 xref_mesh: MESH:C059922
 xref: MetaCyc:334578-HEXAHYDROXYFLAVONE;   PMID:19895818;   PMID:22953867;   PMID:2676226;   PMID:8424824;   Patent:JP55054883;   Patent:WO0103681;   Reaxys:332194;   Wikipedia:Gossypetin
 cyclic_relationship: is_conjugate_acid_of CHEBI:57759;   is_conjugate_acid_of CHEBI:77862



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gossypetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg12 autophagy related 12 multiple interactions ISO gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [ATG5 protein binds to ATG12 protein]] CTD PMID:25622137 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [ATG5 protein binds to ATG12 protein]] CTD PMID:25622137 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Becn1 beclin 1 multiple interactions
increases response to substance
ISO 3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]]; gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]; gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of BECN1 protein]
BECN1 protein results in increased susceptibility to gossypetin
CTD PMID:25622137 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Casp3 caspase 3 multiple interactions ISO gossypetin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased cleavage of CASP3 protein] CTD PMID:25622137 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO gossypetin results in increased expression of CYP1A1 mRNA CTD PMID:29584932 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in decreased phosphorylation of MTOR protein] CTD PMID:25622137 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases activity
multiple interactions
ISO gossypetin results in decreased activity of PARP1 protein
gossypetin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased cleavage of PARP1 protein]
CTD PMID:17884996 PMID:25622137 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 multiple interactions ISO 3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]]; 3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PIK3C3 protein]]; gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]; gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PIK3C3 protein] CTD PMID:25622137 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects response to substance ISO PPARA protein affects the susceptibility to gossypetin CTD PMID:23845592 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects response to substance ISO PPARG protein affects the susceptibility to gossypetin CTD PMID:23845592 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Pten phosphatase and tensin homolog increases expression
multiple interactions
ISO gossypetin results in increased expression of PTEN protein
Enzyme Inhibitors inhibits the reaction [gossypetin results in increased expression of PTEN protein]
CTD PMID:25622137 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO gossypetin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SQSTM1 protein] CTD PMID:25622137 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
JBrowse link
gossypin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf1 activating transcription factor 1 multiple interactions
decreases phosphorylation
ISO gossypin inhibits the reaction [EGF protein results in increased phosphorylation of ATF1 protein]
gossypin results in decreased phosphorylation of ATF1 protein
CTD PMID:30536456 NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670
JBrowse link
G Aurka aurora kinase A multiple interactions ISO gossypin binds to and results in decreased activity of AURKA protein CTD PMID:30536456 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO gossypin results in decreased expression of BCL2L1 protein CTD PMID:30536456 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 increases cleavage ISO gossypin results in increased cleavage of CASP3 protein CTD PMID:30536456 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases cleavage ISO gossypin results in increased cleavage of CASP7 protein CTD PMID:30536456 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp9 caspase 9 increases cleavage ISO gossypin results in increased cleavage of CASP9 protein CTD PMID:30536456 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of CAT protein]; gossypin inhibits the reaction [Oleic Acid results in increased activity of CAT protein] CTD PMID:37148149 PMID:37696682 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO gossypin results in decreased expression of CCNA2 protein CTD PMID:30536456 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO gossypin results in decreased expression of CCNB1 protein CTD PMID:30536456 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases phosphorylation ISO gossypin results in decreased phosphorylation of CDK1 protein CTD PMID:30536456 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Crp C-reactive protein multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of CRP protein] CTD PMID:37148149 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Egf epidermal growth factor multiple interactions ISO gossypin inhibits the reaction [EGF protein results in increased phosphorylation of ATF1 protein] CTD PMID:30536456 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein] CTD PMID:37148149 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il10 interleukin 10 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of IL10 protein] CTD PMID:37148149 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL13 protein] CTD PMID:37148149 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il17a interleukin 17A multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL17A protein] CTD PMID:37148149 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il18 interleukin 18 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 protein] CTD PMID:37148149 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; gossypin inhibits the reaction [Oleic Acid results in increased expression of IL1B mRNA] CTD PMID:37148149 PMID:37696682 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il4 interleukin 4 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of IL4 protein] CTD PMID:37148149 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL5 protein] CTD PMID:37148149 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; gossypin inhibits the reaction [Oleic Acid results in increased expression of IL6 mRNA] CTD PMID:37148149 PMID:37696682 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases phosphorylation ISO gossypin results in decreased phosphorylation of JUN protein CTD PMID:30536456 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein] CTD PMID:37148149 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein] CTD PMID:37148149 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO gossypin results in increased cleavage of PARP1 protein CTD PMID:30536456 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:37148149 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 multiple interactions ISO gossypin binds to and results in decreased activity of RPS6KA3 protein CTD PMID:30536456 NCBI chr  X:35,517,306...35,623,296
Ensembl chr  X:35,517,306...35,623,207
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 protein] CTD PMID:37148149 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; gossypin inhibits the reaction [Oleic Acid results in increased expression of TNF mRNA]; gossypin inhibits the reaction [Oleic Acid results in increased expression of TNF protein] CTD PMID:37148149 PMID:37696682 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    role 19810
      biological role 19808
        biochemical role 19543
          metabolite 19506
            eukaryotic metabolite 19330
              plant metabolite 17968
                gossypetin 39
                  2,3-dihydrogossypetin 0
                  3,3',4',5,7-pentahydroxy-8-methoxyflavone 0
                  gossypetin 8-rhamnoside 0
                  gossypin 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19722
                        carbon atom 19719
                          organic molecular entity 19719
                            organic molecule 19670
                              organic cyclic compound 19481
                                organic heterocyclic compound 18857
                                  oxacycle 17873
                                    benzopyran 11960
                                      1-benzopyran 11714
                                        flavonoid 7202
                                          anthoxanthin 4543
                                            flavones 4543
                                              hydroxyflavone 4521
                                                flavonols 4410
                                                  7-hydroxyflavonol 4387
                                                    gossypetin 39
                                                      2,3-dihydrogossypetin 0
                                                      3,3',4',5,7-pentahydroxy-8-methoxyflavone 0
                                                      gossypetin 8-rhamnoside 0
                                                      gossypin 29
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