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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gossypetin
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Accession:CHEBI:16400 term browser browse the term
Definition:A hexahydroxyflavone having the hydroxy groups placed at the 3-, 3'-, 4'-, 5- 7- and 8-positions.
Synonyms:exact_synonym: 2-(3,4-dihydroxyphenyl)-3,5,7,8-tetrahydroxy-4H-chromen-4-one
 related_synonym: 3,3',4',5,7,8-Hexahydroxyflavone;   Articulatidin;   Equisporol;   Formula=C15H10O8;   InChI=1S/C15H10O8/c16-6-2-1-5(3-7(6)17)14-13(22)12(21)10-8(18)4-9(19)11(20)15(10)23-14/h1-4,16-20,22H;   InChIKey=YRRAGUMVDQQZIY-UHFFFAOYSA-N;   SMILES=Oc1ccc(cc1O)-c1oc2c(O)c(O)cc(O)c2c(=O)c1O
 alt_id: CHEBI:11682;   CHEBI:1362;   CHEBI:19860;   CHEBI:38341
 xref: Beilstein:332194;   CAS:489-35-0;   KEGG:C04109;   KNApSAcK:C00004721;   LINCS:LSM-36971;   LIPID_MAPS_instance:LMPK12113231
 xref_mesh: MESH:C059922
 xref: MetaCyc:334578-HEXAHYDROXYFLAVONE;   PMID:19895818;   PMID:22953867;   PMID:2676226;   PMID:8424824;   Patent:JP55054883;   Patent:WO0103681;   Reaxys:332194;   Wikipedia:Gossypetin
 cyclic_relationship: is_conjugate_acid_of CHEBI:57759;   is_conjugate_acid_of CHEBI:77862


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gossypetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg12 autophagy related 12 multiple interactions ISO gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [ATG5 protein binds to ATG12 protein]] CTD PMID:25622137 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [ATG5 protein binds to ATG12 protein]] CTD PMID:25622137 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Becn1 beclin 1 multiple interactions
increases response to substance
ISO 3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]]; gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]; gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of BECN1 protein]
BECN1 protein results in increased susceptibility to gossypetin
CTD PMID:25622137 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Casp3 caspase 3 multiple interactions ISO gossypetin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased cleavage of CASP3 protein] CTD PMID:25622137 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO gossypetin results in increased expression of CYP1A1 mRNA CTD PMID:29584932 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in decreased phosphorylation of MTOR protein] CTD PMID:25622137 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases activity
multiple interactions
ISO gossypetin results in decreased activity of PARP1 protein
gossypetin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased cleavage of PARP1 protein]
CTD PMID:17884996 PMID:25622137 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 multiple interactions ISO 3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]]; 3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PIK3C3 protein]]; gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]; gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PIK3C3 protein] CTD PMID:25622137 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects response to substance ISO PPARA protein affects the susceptibility to gossypetin CTD PMID:23845592 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects response to substance ISO PPARG protein affects the susceptibility to gossypetin CTD PMID:23845592 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Pten phosphatase and tensin homolog increases expression
multiple interactions
ISO gossypetin results in increased expression of PTEN protein
Enzyme Inhibitors inhibits the reaction [gossypetin results in increased expression of PTEN protein]
CTD PMID:25622137 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO gossypetin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SQSTM1 protein] CTD PMID:25622137 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        biochemical role 19381
          metabolite 19356
            eukaryotic metabolite 19044
              plant metabolite 17455
                gossypetin 12
                  2,3-dihydrogossypetin 0
                  3,3',4',5,7-pentahydroxy-8-methoxyflavone 0
                  gossypetin 8-rhamnoside 0
                  gossypin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic heterocyclic compound 18582
                                  oxacycle 17586
                                    benzopyran 10410
                                      1-benzopyran 10136
                                        flavonoid 6516
                                          flavones 4204
                                            hydroxyflavone 4192
                                              flavonols 4103
                                                7-hydroxyflavonol 4081
                                                  gossypetin 12
                                                    2,3-dihydrogossypetin 0
                                                    3,3',4',5,7-pentahydroxy-8-methoxyflavone 0
                                                    gossypetin 8-rhamnoside 0
                                                    gossypin 0
paths to the root