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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:menaquinone
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Accession:CHEBI:16374 term browser browse the term
Definition:Any member of the class of menaquinones that is 2-methyl-1,4-naphthoquinone with an unsaturated isoprenoid chain at the 3-position.
Synonyms:related_synonym: Formula=(C5H8)nC11H8O2;   Menatetrenone;   a menaquinone;   vitamin K2
 alt_id: CHEBI:14582;   CHEBI:25184;   CHEBI:6749
 xref: CAS:11032-49-8;   KEGG:C00828
 xref_mesh: MESH:D024482
 xref: Wikipedia:Vitamin_K2

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menaquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased phosphorylation of AKT1 protein] CTD PMID:27212383 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases expression
multiple interactions		 EXP Vitamin K 2 results in increased expression of ALPL protein
PTH protein promotes the reaction [Vitamin K 2 results in increased expression of ALPL protein]; Vitamin K 2 affects the reaction [PTH protein results in increased expression of ALPL protein]		 CTD PMID:30639440 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537 		JBrowse link
G Axl Axl receptor tyrosine kinase multiple interactions EXP Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of AXL protein] CTD PMID:27212383 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of BCL2 protein] CTD PMID:27212383 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions
increases secretion
decreases expression		 ISO
EXP		 Vitamin K 2 inhibits the reaction [IL1B protein results in decreased expression of BGLAP protein modified form]
PTH protein promotes the reaction [Vitamin K 2 results in increased carboxylation of BGLAP protein]; PTH protein promotes the reaction [Vitamin K 2 results in increased secretion of BGLAP protein modified form]; Vitamin K 2 promotes the reaction [PTH protein results in increased carboxylation of BGLAP protein]; Vitamin K 2 promotes the reaction [PTH protein results in increased secretion of BGLAP protein modified form]; Vitamin K 2 results in increased carboxylation of and results in decreased secretion of BGLAP protein
Vitamin K 2 results in decreased expression of BGLAP mRNA		 CTD PMID:19675304 PMID:20460758 PMID:30639440 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Vitamin K 2 results in decreased expression of BIRC5 protein CTD PMID:29432837 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions EXP Vitamin K 2 affects the reaction [PTH protein results in increased expression of BMP2 protein] CTD PMID:30639440 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage		 ISO [Vitamin K 2 co-treated with arsenic trioxide] results in increased expression of CASP3; Acetylcysteine inhibits the reaction [[Vitamin K 2 co-treated with arsenic trioxide] results in increased expression of CASP3]
Vitamin K 2 results in increased cleavage of CASP3 protein		 CTD PMID:24273890 PMID:29432837 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 increases cleavage ISO Vitamin K 2 results in increased cleavage of CASP7 protein CTD PMID:29432837 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Vitamin K 2 results in decreased expression of CDK4 mRNA CTD PMID:16010434 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Vitamin K 2 results in increased expression of CDKN1A protein CTD PMID:29432837 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO Vitamin K 2 results in increased expression of CDKN2A mRNA CTD PMID:16010434 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO Vitamin K 2 results in decreased expression of COL1A1 mRNA CTD PMID:19675304 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G F10 coagulation factor X multiple interactions EXP [Phenobarbital co-treated with Vitamin K 2] results in increased activity of F10 protein CTD PMID:19952496 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716 		JBrowse link
G F7 coagulation factor VII multiple interactions EXP [Phenobarbital co-treated with Vitamin K 2] results in increased activity of F7 protein CTD PMID:19952496 NCBI chr16:81,824,610...81,834,923
Ensembl chr16:81,824,111...81,834,945 		JBrowse link
G Gas6 growth arrest specific 6 multiple interactions EXP Vitamin K 2 inhibits the reaction [[Warfarin co-treated with Vitamin K 1] results in decreased expression of GAS6 protein] CTD PMID:27212383 NCBI chr16:81,213,364...81,243,824
Ensembl chr16:81,213,364...81,243,757 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO Vitamin K 2 results in increased phosphorylation of H2AX protein CTD PMID:29432837 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression ISO Vitamin K 2 results in decreased expression of HSPA5 protein CTD PMID:29432837 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases response to substance		 ISO Vitamin K 2 inhibits the reaction [IL1B protein results in decreased expression of BGLAP protein modified form]; Warfarin inhibits the reaction [Vitamin K 2 results in decreased susceptibility to IL1B protein] CTD PMID:20460758 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity		 ISO PROX1 protein inhibits the reaction [Vitamin K 2 results in increased activity of NR1I2 protein] CTD PMID:22023334 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Vitamin K 2 results in increased cleavage of PARP1 protein CTD PMID:29432837 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Prox1 prospero homeobox 1 multiple interactions ISO PROX1 protein inhibits the reaction [Vitamin K 2 results in increased activity of NR1I2 protein] CTD PMID:22023334 NCBI chr13:108,382,536...108,444,107
Ensembl chr13:108,382,399...108,443,294 		JBrowse link
G Pth parathyroid hormone multiple interactions EXP PTH protein promotes the reaction [Vitamin K 2 results in increased carboxylation of BGLAP protein]; PTH protein promotes the reaction [Vitamin K 2 results in increased expression of ALPL protein]; PTH protein promotes the reaction [Vitamin K 2 results in increased expression of RUNX2 protein]; PTH protein promotes the reaction [Vitamin K 2 results in increased expression of SP7 protein]; PTH protein promotes the reaction [Vitamin K 2 results in increased secretion of BGLAP protein modified form]; Vitamin K 2 affects the reaction [PTH protein results in increased expression of ALPL protein]; Vitamin K 2 affects the reaction [PTH protein results in increased expression of BMP2 protein]; Vitamin K 2 affects the reaction [PTH protein results in increased expression of RUNX2 protein]; Vitamin K 2 affects the reaction [PTH protein results in increased expression of SP7 protein]; Vitamin K 2 promotes the reaction [PTH protein results in increased carboxylation of BGLAP protein]; Vitamin K 2 promotes the reaction [PTH protein results in increased secretion of BGLAP protein modified form] CTD PMID:30639440 NCBI chr 1:178,215,829...178,218,761
Ensembl chr 1:178,215,829...178,218,761 		JBrowse link
G Rb1 RB transcriptional corepressor 1 increases expression ISO Vitamin K 2 results in increased expression of RB1 mRNA CTD PMID:16010434 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression
multiple interactions		 EXP Vitamin K 2 results in increased expression of RUNX2 protein
PTH protein promotes the reaction [Vitamin K 2 results in increased expression of RUNX2 protein]; Vitamin K 2 affects the reaction [PTH protein results in increased expression of RUNX2 protein]		 CTD PMID:30639440 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092 		JBrowse link
G Rxra retinoid X receptor alpha multiple interactions
decreases phosphorylation		 ISO [Vitamin K 2 co-treated with 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid] results in decreased phosphorylation of RXRA protein
Vitamin K 2 results in decreased phosphorylation of RXRA protein		 CTD PMID:17270033 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908 		JBrowse link
G Sp7 Sp7 transcription factor increases expression
multiple interactions		 EXP Vitamin K 2 results in increased expression of SP7 protein
PTH protein promotes the reaction [Vitamin K 2 results in increased expression of SP7 protein]; Vitamin K 2 affects the reaction [PTH protein results in increased expression of SP7 protein]		 CTD PMID:30639440 NCBI chr 7:143,957,316...143,967,488
Ensembl chr 7:143,958,858...143,967,484 		JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression ISO Vitamin K 2 results in decreased expression of TNFSF11 mRNA CTD PMID:19675304 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704 		JBrowse link
menaquinone-7 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bglap bone gamma-carboxyglutamate protein multiple interactions
increases carboxylation		 ISO Warfarin inhibits the reaction [vitamin MK 7 results in increased carboxylation of BGLAP protein] CTD PMID:31173816 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression ISO vitamin MK 7 results in increased expression of TNFRSF11B mRNA CTD PMID:31173816 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665 		JBrowse link
menatetrenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated increases activity ISO menatetrenone results in increased activity of ALPL protein CTD PMID:11113387 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression
increases carboxylation
multiple interactions		 ISO menatetrenone results in increased expression of BGLAP mRNA
menatetrenone results in increased carboxylation of BGLAP protein
Warfarin inhibits the reaction [menatetrenone results in increased carboxylation of BGLAP protein]		 CTD PMID:11113387 PMID:31173816 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions
increases response to substance
increases expression		 ISO Coumestrol inhibits the reaction [menatetrenone promotes the reaction [Phosphates results in increased expression of BMP2 mRNA]]; Coumestrol inhibits the reaction [menatetrenone results in increased expression of BMP2 mRNA]; Coumestrol inhibits the reaction [menatetrenone results in increased susceptibility to BMP2 protein]; Coumestrol inhibits the reaction [Phosphates promotes the reaction [menatetrenone results in increased expression of BMP2 mRNA]]; Ketoconazole inhibits the reaction [menatetrenone promotes the reaction [Phosphates results in increased expression of BMP2 mRNA]]; Ketoconazole inhibits the reaction [Phosphates promotes the reaction [menatetrenone results in increased expression of BMP2 mRNA]]; menatetrenone promotes the reaction [Phosphates results in increased expression of BMP2 mRNA]; Phosphates promotes the reaction [menatetrenone results in increased expression of BMP2 mRNA] CTD PMID:31843813 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO menatetrenone results in increased activity of NR1I2 protein CTD PMID:31843813 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression ISO menatetrenone results in increased expression of TNFRSF11B mRNA CTD PMID:31173816 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO menatetrenone inhibits the reaction [Calcitriol results in increased expression of TNFSF11 mRNA] CTD PMID:11113387 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704 		JBrowse link
G Ubiad1 UbiA prenyltransferase domain containing 1 multiple interactions ISO [UBIAD1 protein results in increased metabolism of Vitamin K metabolite] which results in increased chemical synthesis of menatetrenone CTD PMID:20953171 NCBI chr 5:165,247,630...165,259,228
Ensembl chr 5:165,247,133...165,259,224 		JBrowse link
vitamin K term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP [Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of ACTA2 mRNA CTD PMID:23117658 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394 		JBrowse link
G Apoe apolipoprotein E affects abundance
affects uptake		 ISO APOE protein affects the abundance of Vitamin K
APOE protein affects the uptake of Vitamin K		 CTD PMID:15952022 PMID:16847429 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057 		JBrowse link
G Axin2 axin 2 multiple interactions EXP [Warfarin co-treated with Vitamin K] results in increased expression of AXIN2 mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of AXIN2 mRNA] CTD PMID:23117658 NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642 		JBrowse link
G Axl Axl receptor tyrosine kinase multiple interactions
increases expression		 ISO Vitamin K inhibits the reaction [Warfarin results in decreased expression of AXL protein modified form]
Vitamin K results in increased expression of AXL protein modified form		 CTD PMID:26206560 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions EXP [Warfarin co-treated with Vitamin K] results in increased expression of BGLAP mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of BGLAP mRNA] CTD PMID:23117658 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP [Warfarin co-treated with Vitamin K] results in increased expression of CCND1 mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of CCND1 mRNA] CTD PMID:23117658 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cnn1 calponin 1 multiple interactions EXP [Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of CNN1 mRNA CTD PMID:23117658 NCBI chr 8:23,113,083...23,121,748
Ensembl chr 8:23,113,048...23,121,761 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP [Warfarin co-treated with Vitamin K] results in increased expression of COL1A1 mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of COL1A1 mRNA] CTD PMID:23117658 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions
affects expression
decreases expression		 EXP Lipopolysaccharides promotes the reaction [Vitamin K deficiency results in decreased expression of CYP11A1 mRNA]; Lipopolysaccharides promotes the reaction [Vitamin K deficiency results in decreased expression of CYP11A1 protein]
Vitamin K affects the expression of CYP11A1 mRNA
Vitamin K deficiency results in decreased expression of CYP11A1 mRNA; Vitamin K deficiency results in decreased expression of CYP11A1 protein		 CTD PMID:16844298 PMID:21894328 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893 		JBrowse link
G Fgg fibrinogen gamma chain affects expression EXP Vitamin K affects the expression of FGG mRNA CTD PMID:16636460 NCBI chr 2:181,987,080...181,994,523
Ensembl chr 2:181,987,217...181,994,514 		JBrowse link
G Fnta farnesyltransferase, CAAX box, alpha affects expression EXP Vitamin K affects the expression of FNTA mRNA CTD PMID:16844298 NCBI chr16:70,834,957...70,854,724
Ensembl chr16:70,834,957...70,854,724 		JBrowse link
G Gas6 growth arrest specific 6 affects carboxylation EXP Vitamin K affects the carboxylation of GAS6 protein CTD PMID:9163328 NCBI chr16:81,213,364...81,243,824
Ensembl chr16:81,213,364...81,243,757 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP [Warfarin co-treated with Vitamin K] results in increased phosphorylation of GSK3B protein; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased phosphorylation of GSK3B protein] CTD PMID:23117658 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Warfarin co-treated with Vitamin K] results in increased expression of IL1B mRNA CTD PMID:23117658 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Warfarin co-treated with Vitamin K] results in increased expression of IL6 mRNA CTD PMID:23117658 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Lss lanosterol synthase affects expression EXP Vitamin K affects the expression of LSS mRNA CTD PMID:16844298 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497 		JBrowse link
G Mgp matrix Gla protein multiple interactions EXP [Vitamin K co-treated with Warfarin] results in increased carboxylation of MGP protein CTD PMID:23223575 NCBI chr 4:170,856,783...170,860,105
Ensembl chr 4:170,856,751...170,860,225 		JBrowse link
G Mvd mevalonate diphosphate decarboxylase affects expression EXP Vitamin K affects the expression of MVD mRNA CTD PMID:16844298 NCBI chr19:55,258,910...55,268,933
Ensembl chr19:55,258,905...55,268,951 		JBrowse link
G Myh1 myosin heavy chain 1 multiple interactions EXP [Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of MYH1 mRNA CTD PMID:23117658 NCBI chr10:53,740,841...53,764,610
Ensembl chr10:53,713,938...53,848,347 		JBrowse link
G Numb NUMB, endocytic adaptor protein multiple interactions EXP [Warfarin co-treated with Vitamin K] results in increased expression of NUMB mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of NUMB mRNA] CTD PMID:23117658 NCBI chr 6:107,279,917...107,325,345
Ensembl chr 6:107,279,920...107,325,345 		JBrowse link
G Orm1 orosomucoid 1 affects expression EXP Vitamin K affects the expression of ORM1 mRNA CTD PMID:16636460 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820 		JBrowse link
G Pros1 protein S multiple interactions ISO Vitamin K affects the carboxylation of and affects the secretion of PROS1 protein CTD PMID:10706868 NCBI chr 7:1,206,648...1,288,140
Ensembl chr 7:1,206,648...1,288,134 		JBrowse link
G Pth parathyroid hormone increases activity ISO Vitamin K results in increased activity of PTH protein CTD PMID:11564701 NCBI chr 1:178,215,829...178,218,761
Ensembl chr 1:178,215,829...178,218,761 		JBrowse link
G Rabggta Rab geranylgeranyltransferase subunit alpha affects expression EXP Vitamin K affects the expression of RABGGTA mRNA CTD PMID:16844298 NCBI chr15:34,393,419...34,400,466
Ensembl chr15:34,393,233...34,400,449 		JBrowse link
G Rabggtb Rab geranylgeranyltransferase subunit beta affects expression EXP Vitamin K affects the expression of RABGGTB mRNA CTD PMID:16844298 NCBI chr 2:260,110,309...260,115,574
Ensembl chr 2:260,110,309...260,115,577 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Vitamin K deficiency promotes the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:21894328 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator affects expression EXP Vitamin K affects the expression of RRAD mRNA CTD PMID:16844298 NCBI chr19:561,696...564,929
Ensembl chr19:561,727...564,930 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions EXP [Warfarin co-treated with Vitamin K] results in increased expression of RUNX2 mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of RUNX2 mRNA] CTD PMID:23117658 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP [Warfarin co-treated with Vitamin K] results in increased expression of SPP1 mRNA CTD PMID:23117658 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901 		JBrowse link
G Tagln transgelin multiple interactions EXP [Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of TAGLN mRNA CTD PMID:23117658 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357 		JBrowse link
G Tcf4 transcription factor 4 multiple interactions EXP [Warfarin co-treated with Vitamin K] results in increased expression of TCF4 mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of TCF4 mRNA] CTD PMID:23117658 NCBI chr18:65,285,320...65,507,983
Ensembl chr18:65,155,685...65,507,977 		JBrowse link
G Tgm2 transglutaminase 2 multiple interactions EXP [Warfarin co-treated with Vitamin K] results in increased expression of and results in increased activity of TGM2 protein; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of and results in increased activity of TGM2 protein] CTD PMID:23117658 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Warfarin co-treated with Vitamin K] results in increased expression of TNF mRNA CTD PMID:23117658 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Ubiad1 UbiA prenyltransferase domain containing 1 increases metabolic processing
multiple interactions		 ISO UBIAD1 protein results in increased metabolism of Vitamin K metabolite
[UBIAD1 protein results in increased metabolism of Vitamin K metabolite] which results in increased chemical synthesis of menatetrenone		 CTD PMID:20953171 NCBI chr 5:165,247,630...165,259,228
Ensembl chr 5:165,247,133...165,259,224 		JBrowse link
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Path 1
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  CHEBI ontology 19883
    role 19833
      biological role 19833
        biochemical role 19370
          metabolite 19350
            prokaryotic metabolite 18441
              bacterial metabolite 18441
                Escherichia coli metabolite 18321
                  menaquinone 56
                    menaquinone-7 2
                    menaquinone-8 0
                    menaquinone-9 + 0
                    menatetrenone + 7
                    vitamin K + 34
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic group 18580
                              organic divalent group 18571
                                organodiyl group 18571
                                  carbonyl group 18479
                                    carbonyl compound 18479
                                      ketone 16222
                                        cyclic ketone 13938
                                          quinone 8388
                                            p-quinones 8292
                                              prenylquinone 123
                                                prenylnaphthoquinone 56
                                                  menaquinones 56
                                                    menaquinone 56
                                                      menaquinone-7 2
                                                      menaquinone-8 0
                                                      menaquinone-9 + 0
                                                      menatetrenone + 7
                                                      vitamin K + 34
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