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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3',5'-cyclic GMP
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Accession:CHEBI:16356 term browser browse the term
Definition:A 3',5'-cyclic purine nucleotide in which the purine nucleobase is specified as guanidine.
Synonyms:exact_synonym: guanosine 3',5'-(hydrogen phosphate)
 related_synonym: Cyclic GMP;   Formula=C10H12N5O7P;   Guanosine 3',5'-cyclic monophosphate;   Guanosine 3',5'-cyclic phosphate;   Guanosine cyclic monophosphate;   InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/t3-,5-,6-,9-/m1/s1;   InChIKey=ZOOGRGPOEVQQDX-UUOKFMHZSA-N;   SMILES=Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O;   cGMP
 alt_id: CHEBI:11675;   CHEBI:1327;   CHEBI:14377;   CHEBI:19829;   CHEBI:39915;   CHEBI:44955;   CHEBI:44957
 xref: CAS:7665-99-8;   DrugBank:DB02315;   HMDB:HMDB0001314;   KEGG:C00942;   KNApSAcK:C00019673
 xref_mesh: MESH:D006152
 xref: PDBeChem:35G;   PDBeChem:PCG;   PMID:24591051;   PMID:24705918;   Reaxys:586222
 cyclic_relationship: is_conjugate_acid_of CHEBI:57746


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3',5'-cyclic GMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDE5A phosphodiesterase 5A increases degradation EXP PDE5 protein results in increased degradation of Cyclic GMP CTD PMID:18669600 NCBI chr 8:104,270,858...104,420,955
Ensembl chr 8:104,270,881...104,420,947
JBrowse link
G PDE6C phosphodiesterase 6C increases degradation EXP PDE6C protein results in increased degradation of Cyclic GMP CTD PMID:18669600 NCBI chr14:105,010,974...105,122,628
Ensembl chr14:105,011,922...105,037,498
Ensembl chr14:105,011,922...105,037,498
JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 increases activity EXP Cyclic GMP results in increased activity of PRKG1 protein CTD PMID:18037907 NCBI chr14:97,558,531...98,793,080
Ensembl chr14:97,560,785...98,793,318
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 874
    role 854
      biological role 854
        biochemical role 725
          metabolite 713
            eukaryotic metabolite 687
              plant metabolite 402
                3',5'-cyclic GMP 3
                  (Rp)-cGMPS 0
                  (Sp)-8-Br-cGMPS 0
                  (Sp)-cGMPS 0
                  8-(4-chlorophenylthio)-cGMP 0
                  8-(6-aminohexylthio)-cGMP 0
                  8-bromo-3',5'-cyclic GMP 0
                  8-nitroguanosine 3',5'-cyclic monophosphate 0
                  N(1)-methyl-cGMP 0
                  N(2),3-etheno-cGMP 0
                  N(2),N(2)-dimethyl-cGMP 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 874
    subatomic particle 859
      composite particle 859
        hadron 859
          baryon 859
            nucleon 859
              atomic nucleus 859
                atom 859
                  main group element atom 849
                    p-block element atom 846
                      chalcogen 808
                        oxygen atom 755
                          oxygen molecular entity 755
                            hydroxides 680
                              oxoacid 311
                                pnictogen oxoacid 59
                                  phosphorus oxoacid 57
                                    phosphoric acids 48
                                      phosphoric acid 48
                                        phosphoric acid derivative 48
                                          phosphate 48
                                            organic phosphate 48
                                              carbohydrate phosphate 26
                                                phospho sugar 14
                                                  aldose phosphate 14
                                                    aldopentose phosphate 14
                                                      ribose phosphate 14
                                                        ribonucleotide 14
                                                          purine ribonucleotide 14
                                                            guanyl ribonucleotide 3
                                                              3',5'-cyclic GMP 3
                                                                (Rp)-cGMPS 0
                                                                (Sp)-8-Br-cGMPS 0
                                                                (Sp)-cGMPS 0
                                                                8-(4-chlorophenylthio)-cGMP 0
                                                                8-(6-aminohexylthio)-cGMP 0
                                                                8-bromo-3',5'-cyclic GMP 0
                                                                8-nitroguanosine 3',5'-cyclic monophosphate 0
                                                                N(1)-methyl-cGMP 0
                                                                N(2),3-etheno-cGMP 0
                                                                N(2),N(2)-dimethyl-cGMP 0
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