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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3-nitropropanoic acid
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Accession:CHEBI:16348 term browser browse the term
Definition:A C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group.
Synonyms:related_synonym: 3-nitropropionic acid;   Bovinocidin;   Formula=C3H5NO4;   InChI=1S/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6);   InChIKey=WBLZUCOIBUDNBV-UHFFFAOYSA-N;   SMILES=OC(CC[N+]([O-])=O)=O;   beta-Nitropropanoic acid;   beta-Nitropropionic acid
 alt_id: CHEBI:10434;   CHEBI:11864;   CHEBI:1611;   CHEBI:20145;   CHEBI:22852;   CHEBI:39918
 xref: Beilstein:1759889;   CAS:504-88-1;   Gmelin:533092;   KEGG:C05669;   KNApSAcK:C00018684;   LINCS:LSM-6632
 xref_mesh: MESH:C015392
 xref: PDBeChem:3NP;   PMID:11409756;   PMID:11785916;   PMID:14700739;   PMID:16038559;   PMID:16300642;   PMID:16443208;   PMID:16940769;   PMID:17183449;   PMID:17344940;   PMID:17566644;   PMID:19755148;   PMID:19763544;   PMID:19779956;   PMID:25963711;   PMID:26796265;   PMID:26957301;   PMID:27289244;   PMID:27682807;   PMID:27690136;   PMID:27890093;   PMID:28164735;   PMID:28271107;   PMID:8848189
 cyclic_relationship: is_conjugate_acid_of CHEBI:59899;   is_tautomer_of CHEBI:16775


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3-nitropropanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
increases activity 		EXP thymoquinone inhibits the reaction [3-nitropropionic acid results in increased activity of ACHE protein]; trandolapril inhibits the reaction [3-nitropropionic acid results in increased activity of ACHE protein] CTD PMID:25445565 PMID:27206696 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions 		EXP 3-nitropropionic acid results in decreased phosphorylation of AKT1 protein
methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of AKT1 protein]]; N(6)-cyclohexyladenosine inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of AKT1 protein]; Topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of AKT1 protein]; Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of AKT1 protein] 		CTD PMID:29753867 PMID:36509115 PMID:38513929 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
increases expression 		EXP naringin inhibits the reaction [3-nitropropionic acid results in increased expression of BAD mRNA] CTD PMID:21945202 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization
multiple interactions
increases expression 		EXP 3-nitropropionic acid affects the localization of BAX protein
[Tacrolimus co-treated with 3-nitropropionic acid] affects the localization of BAX protein; Ginkgo biloba extract inhibits the reaction [3-nitropropionic acid results in increased expression of BAX mRNA]; methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of BAX protein]]; naringin inhibits the reaction [3-nitropropionic acid results in increased expression of BAX mRNA]; Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of BAX protein]; ursodoxicoltaurine inhibits the reaction [3-nitropropionic acid affects the localization of BAX protein]
3-nitropropionic acid results in increased expression of BAX mRNA; 3-nitropropionic acid results in increased expression of BAX protein 		CTD PMID:11080188 PMID:15571979 PMID:21827809 PMID:21945202 PMID:38513929 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression 		EXP
ISO 		[Tacrolimus co-treated with 3-nitropropionic acid] affects the localization of BCL2 protein; BCL2 protein promotes the reaction [BDNF protein results in decreased susceptibility to 3-nitropropionic acid]; methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased expression of BCL2 protein]]; naringin inhibits the reaction [3-nitropropionic acid results in decreased expression of BCL2 mRNA]; Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased expression of BCL2 protein]
3-nitropropionic acid results in decreased expression of BCL2 mRNA; 3-nitropropionic acid results in decreased expression of BCL2 protein
3-nitropropionic acid inhibits the reaction [ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in decreased expression of BCL2 protein]] 		CTD PMID:15571979 PMID:19428112 PMID:21945202 PMID:37308051 PMID:38513929 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions 		EXP
ISO 		3-nitropropionic acid results in decreased expression of BCL2L1 mRNA
Ginkgo biloba extract inhibits the reaction [3-nitropropionic acid results in decreased expression of BCL2L1 mRNA]
3-nitropropionic acid inhibits the reaction [ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in decreased expression of BCL2L1 protein]] 		CTD PMID:21827809 PMID:37308051 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Bdnf brain-derived neurotrophic factor decreases response to substance
multiple interactions
decreases expression 		EXP BDNF protein results in decreased susceptibility to 3-nitropropionic acid
BCL2 protein promotes the reaction [BDNF protein results in decreased susceptibility to 3-nitropropionic acid]; Dinitrochlorobenzene inhibits the reaction [BDNF protein results in decreased susceptibility to 3-nitropropionic acid]; KT 5823 inhibits the reaction [BDNF protein results in decreased susceptibility to 3-nitropropionic acid]; N(6)-cyclohexyladenosine inhibits the reaction [3-nitropropionic acid results in decreased expression of BDNF protein]; Topiramate inhibits the reaction [3-nitropropionic acid results in decreased expression of BDNF protein] 		CTD PMID:19428112 PMID:29753867 PMID:36509115 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Casp2 caspase 2 increases activity EXP 3-nitropropionic acid results in increased activity of CASP2 protein CTD PMID:15571979 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage
increases expression 		EXP
ISO 		3-nitropropionic acid results in increased activity of CASP3 protein
methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of CASP3 protein]]; naringin inhibits the reaction [3-nitropropionic acid results in increased cleavage of CASP3 protein]; Tacrolimus inhibits the reaction [3-nitropropionic acid results in increased activity of CASP3 protein]; Topiramate inhibits the reaction [3-nitropropionic acid results in increased activity of CASP3 protein]; Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of CASP3 protein]
3-nitropropionic acid inhibits the reaction [ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased cleavage of CASP3 protein]] 		CTD PMID:15571979 PMID:21945202 PMID:29753867 PMID:37308051 PMID:38513929 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity EXP 3-nitropropionic acid results in increased activity of CASP8 protein CTD PMID:15571979 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity EXP 3-nitropropionic acid results in increased activity of CASP9 protein CTD PMID:15571979 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cat catalase multiple interactions
decreases expression
decreases activity 		EXP 3-nitropropionic acid affects the reaction [[lead acetate results in increased abundance of Lead] affects the reaction [Ethanol affects the expression of CAT protein]]; 3-nitropropionic acid affects the reaction [[lead acetate results in increased abundance of Lead] which affects the expression of CAT protein]; 3-nitropropionic acid affects the reaction [Ethanol affects the expression of CAT protein]; Cyclosporine inhibits the reaction [3-nitropropionic acid results in decreased expression of CAT protein]; naringin inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; Nitric Oxide promotes the reaction [Sertraline inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]]; Nitric Oxide promotes the reaction [Venlafaxine Hydrochloride inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]]; Sertraline inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; thymoquinone analog inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; trandolapril inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; Venlafaxine Hydrochloride inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein] CTD PMID:20305041 PMID:20448265 PMID:21945202 PMID:25445565 PMID:27206696 More... NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 increases expression EXP 3-nitropropionic acid results in increased expression of CCND1 protein CTD PMID:21827787 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression EXP 3-nitropropionic acid results in increased expression of CDK4 protein CTD PMID:21827787 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cnr1 cannabinoid receptor 1 affects expression EXP 3-nitropropionic acid affects the expression of CNR1 mRNA CTD PMID:15640759 NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 decreases expression ISO 3-nitropropionic acid results in decreased expression of COX4I1 mRNA CTD PMID:19306371 NCBI chr19:65,630,383...65,636,623
Ensembl chr19:48,721,199...48,727,921 		JBrowse link
G Cox4i2 cytochrome c oxidase subunit 4i2 increases response to substance
increases expression
increases expression 		ISO COX4I2 mRNA results in increased susceptibility to 3-nitropropionic acid
3-nitropropionic acid results in increased expression of COX4I2 mRNA
3-nitropropionic acid increases expression of Cox4i2 mRNA in primary astrocytes 		CTD
RGD		 PMID:19306371 PMID:19306371 RGD:13506652 NCBI chr 3:161,686,193...161,699,605
Ensembl chr 3:141,228,443...141,239,331 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
decreases phosphorylation 		EXP N(6)-cyclohexyladenosine inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of CREB1 protein]; Topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of CREB1 protein] CTD PMID:29753867 PMID:36509115 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Dnm1l dynamin 1-like increases expression EXP 3-nitropropionic acid results in increased expression of DNM1L protein CTD PMID:37116597 NCBI chr11:98,084,049...98,135,663
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Eno2 enolase 2 decreases expression
multiple interactions 		EXP 3-nitropropionic acid results in decreased expression of ENO2 mRNA
Cannabidiol inhibits the reaction [3-nitropropionic acid results in decreased expression of ENO2 mRNA] 		CTD PMID:17672854 NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:157,572,088...157,580,980 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions
increases expression 		EXP Ginkgo biloba extract inhibits the reaction [3-nitropropionic acid results in increased expression of GAPDH mRNA] CTD PMID:21827809 NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions EXP [naringin co-treated with 3-nitropropionic acid] results in increased expression of GCLC mRNA CTD PMID:22871521 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 decreases expression
multiple interactions 		EXP 3-nitropropionic acid results in decreased expression of GRIA2 mRNA
topiramate inhibits the reaction [3-nitropropionic acid results in decreased expression of GRIA2 mRNA] 		CTD PMID:29753867 NCBI chr 2:168,247,490...168,367,616
Ensembl chr 2:165,947,521...166,069,510 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B increases response to substance EXP GRIN2B protein results in increased susceptibility to 3-nitropropionic acid CTD PMID:16919272 NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
multiple interactions 		EXP 3-nitropropionic acid results in decreased phosphorylation of GSK3B protein
topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of GSK3B protein] 		CTD PMID:29753867 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity 		EXP naringin inhibits the reaction [3-nitropropionic acid results in decreased activity of GSR protein]; thymoquinone analog inhibits the reaction [3-nitropropionic acid results in decreased activity of GSR protein]; thymoquinone inhibits the reaction [3-nitropropionic acid results in decreased activity of GSR protein] CTD PMID:21945202 PMID:27206696 PMID:37116597 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions EXP [naringin co-treated with 3-nitropropionic acid] results in increased expression of GSTP1 mRNA CTD PMID:22871521 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases activity 		EXP [naringin co-treated with 3-nitropropionic acid] results in increased expression of HMOX1 mRNA; methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased activity of HMOX1 protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased activity of HMOX1 protein] CTD PMID:22871521 PMID:38513929 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression EXP 3-nitropropionic acid results in increased expression of HSPA5 protein CTD PMID:37116597 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 increases expression EXP 3-nitropropionic acid results in increased expression of HSPA9 protein CTD PMID:37116597 NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,535,798...26,554,292 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression 		EXP methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of IL1B protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of IL1B protein] CTD PMID:38513929 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions 		ISO 3-nitropropionic acid results in increased expression of IL6 mRNA
delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-nitropropionic acid results in increased expression of IL6 mRNA] 		CTD PMID:28853159 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 decreases expression EXP 3-nitropropionic acid results in decreased expression of ITPR1 protein CTD PMID:37116597 NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Jak2 Janus kinase 2 increases phosphorylation
multiple interactions 		EXP 3-nitropropionic acid results in increased phosphorylation of JAK2 protein
methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased phosphorylation of JAK2 protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in increased phosphorylation of JAK2 protein] 		CTD PMID:38513929 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO 3-nitropropionic acid inhibits the reaction [Curcumin results in increased localization of MAP1LC3B protein] CTD PMID:37634662 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions 		EXP 3-nitropropionic acid results in decreased phosphorylation of MAPK1 protein
N(6)-cyclohexyladenosine inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of MAPK1 protein] 		CTD PMID:36509115 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation 		EXP N(6)-cyclohexyladenosine inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of MAPK3 protein] CTD PMID:36509115 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapt microtubule-associated protein tau affects localization EXP 3-nitropropionic acid affects the localization of MAPT protein CTD PMID:17634376 NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mfn1 mitofusin 1 increases expression EXP 3-nitropropionic acid results in increased expression of MFN1 protein CTD PMID:37116597 NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:115,313,401...115,359,640 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression EXP 3-nitropropionic acid results in decreased expression of MKI67 protein CTD PMID:21827787 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases expression 		EXP [naringin co-treated with 3-nitropropionic acid] affects the localization of NFE2L2 protein; methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased expression of NFE2L2 protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased expression of NFE2L2 protein] CTD PMID:22871521 PMID:38513929 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases response to substance ISO NFKB1 results in decreased susceptibility to 3-nitropropionic acid CTD PMID:11211235 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions 		EXP
ISO 		3-nitropropionic acid results in increased expression of NOS2 mRNA; 3-nitropropionic acid results in increased expression of NOS2 protein
N(6)-cyclohexyladenosine inhibits the reaction [3-nitropropionic acid results in increased expression of NOS2 protein]; naringin inhibits the reaction [3-nitropropionic acid results in increased expression of NOS2 mRNA]
delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-nitropropionic acid results in increased expression of NOS2 mRNA]; T 0070907 inhibits the reaction [delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-nitropropionic acid results in increased expression of NOS2 mRNA]] 		CTD PMID:22871521 PMID:28853159 PMID:36509115 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [naringin co-treated with 3-nitropropionic acid] results in increased expression of NQO1 mRNA CTD PMID:22871521 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions
decreases phosphorylation 		EXP N(6)-cyclohexyladenosine inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of NTRK2 protein] CTD PMID:36509115 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Penk proenkephalin decreases expression
multiple interactions 		EXP 3-nitropropionic acid results in decreased expression of PENK mRNA
Cannabidiol inhibits the reaction [3-nitropropionic acid results in decreased expression of PENK mRNA] 		CTD PMID:17672854 NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Pick1 protein interacting with PRKCA 1 increases expression
multiple interactions 		EXP 3-nitropropionic acid results in increased expression of PICK1 protein
topiramate inhibits the reaction [3-nitropropionic acid results in increased expression of PICK1 protein] 		CTD PMID:29753867 NCBI chr 7:112,676,890...112,697,275
Ensembl chr 7:110,797,117...110,816,848 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO 3-nitropropionic acid inhibits the reaction [ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased cleavage of and results in increased phosphorylation of PRKCD protein]] CTD PMID:37308051 NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions 		EXP 3-nitropropionic acid results in increased expression of PTGS2 mRNA
naringin inhibits the reaction [3-nitropropionic acid results in increased expression of PTGS2 mRNA] 		CTD PMID:22871521 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression EXP 3-nitropropionic acid results in decreased expression of RB1 protein CTD PMID:21827787 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation
multiple interactions 		EXP 3-nitropropionic acid results in increased phosphorylation of RELA protein
methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased phosphorylation of RELA protein]]; N(6)-cyclohexyladenosine inhibits the reaction [3-nitropropionic acid results in increased phosphorylation of RELA protein]; Tropisetron inhibits the reaction [3-nitropropionic acid results in increased phosphorylation of RELA protein] 		CTD PMID:36509115 PMID:38513929 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sirt1 sirtuin 1 decreases expression ISO
EXP 		3-nitropropionic acid results in decreased expression of SIRT1 protein CTD PMID:18538940 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression 		EXP Cannabidiol inhibits the reaction [3-nitropropionic acid results in decreased expression of SOD1 mRNA] CTD PMID:17672854 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression
multiple interactions 		EXP 3-nitropropionic acid results in decreased expression of SOD2 mRNA
Cannabidiol inhibits the reaction [3-nitropropionic acid results in decreased expression of SOD2 mRNA] 		CTD PMID:17672854 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Syp synaptophysin multiple interactions
affects expression 		EXP Bezafibrate affects the reaction [3-nitropropionic acid affects the expression of SYP protein] CTD PMID:37116597 NCBI chr  X:17,521,348...17,536,449
Ensembl chr  X:14,849,444...14,864,745 		JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression
multiple interactions 		EXP 3-nitropropionic acid results in decreased expression of TAC1 mRNA
Cannabidiol inhibits the reaction [3-nitropropionic acid results in decreased expression of TAC1 mRNA] 		CTD PMID:17672854 NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions 		EXP
ISO 		3-nitropropionic acid results in increased expression of TNF mRNA; 3-nitropropionic acid results in increased expression of TNF protein
methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of TNF protein]]; N(6)-cyclohexyladenosine inhibits the reaction [3-nitropropionic acid results in increased expression of TNF protein]; naringin inhibits the reaction [3-nitropropionic acid results in increased expression of TNF mRNA]; Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of TNF protein]
delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-nitropropionic acid results in increased expression of TNF mRNA]; T 0070907 inhibits the reaction [delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-nitropropionic acid results in increased expression of TNF mRNA]] 		CTD PMID:22871521 PMID:28853159 PMID:36509115 PMID:38513929 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 increases expression EXP 3-nitropropionic acid results in increased expression of VDAC1 protein CTD PMID:37116597 NCBI chr10:37,029,377...37,060,542
Ensembl chr10:36,532,244...36,559,640 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      biological role 20814
        aetiopathogenetic role 19855
          neurotoxin 18714
            3-nitropropanoic acid 58
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            heteroorganic entity 20215
                              organochalcogen compound 19902
                                organooxygen compound 19804
                                  carbon oxoacid 19150
                                    carboxylic acid 19147
                                      monocarboxylic acid 18300
                                        fatty acid 16989
                                          saturated fatty acid 16681
                                            propionic acid 3890
                                              3-nitropropanoic acid 58
paths to the root