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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phosphatidic acid
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Accession:CHEBI:16337 term browser browse the term
Definition:A derivative of glycerol in which one hydroxy group, commonly but not necessarily primary, is esterified with phosphoric acid and the other two are esterified with fatty acids.
Synonyms:related_synonym: 1,2-Diacyl-sn-glycerol 3-phosphate;   3-sn-Phosphatidate;   Formula=C5H7O8PR2;   Phosphatidate;   SMILES=OP(O)(=O)OCC(COC([*])=O)OC([*])=O;   phosphatidic acids
 alt_id: CHEBI:14795;   CHEBI:26023;   CHEBI:8122;   MESH:D010712
 xref: KEGG:C00416
 xref_mesh: MESH:D010712
 cyclic_relationship: is_conjugate_acid_of CHEBI:57739


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phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen increases abundance EXP AGT protein results in increased abundance of Phosphatidic Acids CTD PMID:14613874 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO
EXP
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Phosphatidic Acids results in increased phosphorylation of AKT1 protein]
R 59949 inhibits the reaction [Phosphatidic Acids results in increased phosphorylation of AKT1 protein]
CTD PMID:15525798 PMID:16354768 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Avp arginine vasopressin increases abundance
multiple interactions
EXP AVP protein results in increased abundance of Phosphatidic Acids
2-(4-amylcinnamoyl)amino-4-chlorobenzoic acid inhibits the reaction [AVP protein results in increased abundance of Phosphatidic Acids]
CTD PMID:11356622 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases activity ISO Phosphatidic Acids results in increased activity of BGLAP protein CTD PMID:16857255 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Egf epidermal growth factor multiple interactions
increases abundance
EXP 1-Butanol inhibits the reaction [EGF protein results in increased abundance of Phosphatidic Acids] CTD PMID:11134345 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase increases activity ISO Phosphatidic Acids results in increased activity of FGR protein CTD PMID:11078731 NCBI chr 5:151,172,189...151,199,746
Ensembl chr 5:151,172,206...151,199,745
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
ISO alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Phosphatidic Acids results in increased secretion of IL1B protein] CTD PMID:16354768 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
ISO alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Phosphatidic Acids results in increased secretion of IL6 protein] CTD PMID:16354768 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jak2 Janus kinase 2 increases phosphorylation ISO Phosphatidic Acids results in increased phosphorylation of JAK2 protein CTD PMID:16354768 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Phosphatidic Acids inhibits the reaction [Ethanol results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]; Phosphatidic Acids results in increased phosphorylation of and results in increased activity of MAPK1 protein; U 0126 inhibits the reaction [Phosphatidic Acids results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:18358832 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Phosphatidic Acids inhibits the reaction [Ethanol results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]; Phosphatidic Acids results in increased phosphorylation of and results in increased activity of MAPK3 protein; U 0126 inhibits the reaction [Phosphatidic Acids results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:18358832 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases activity
multiple interactions
ISO Phosphatidic Acids results in increased activity of MMP2 protein
Quercetin inhibits the reaction [Phosphatidic Acids results in increased activity of MMP2 protein]
CTD PMID:21867678 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases activity
ISO MTOR protein affects the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein]
Phosphatidic Acids results in increased activity of MTOR protein
CTD PMID:12087098 PMID:16537399 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions EXP [1-Butanol inhibits the reaction [PLD2 protein results in increased chemical synthesis of Phosphatidic Acids]] affects the reaction [PENK protein binds to and results in increased activity of OPRM1 protein] CTD PMID:14720217 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Penk proenkephalin multiple interactions EXP [1-Butanol inhibits the reaction [PLD2 protein results in increased chemical synthesis of Phosphatidic Acids]] affects the reaction [PENK protein binds to and results in increased activity of OPRM1 protein] CTD PMID:14720217 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837
JBrowse link
G Pld1 phospholipase D1 increases activity ISO Phosphatidic Acids results in increased activity of PLD1 protein CTD PMID:16857255 NCBI chr 2:113,651,967...113,849,403
Ensembl chr 2:113,652,348...113,849,403
JBrowse link
G Pld2 phospholipase D2 multiple interactions EXP 1-Butanol inhibits the reaction [PLD2 protein results in increased chemical synthesis of Phosphatidic Acids]; [1-Butanol inhibits the reaction [PLD2 protein results in increased chemical synthesis of Phosphatidic Acids]] affects the reaction [PENK protein binds to and results in increased activity of OPRM1 protein] CTD PMID:14720217 NCBI chr10:57,161,921...57,181,148
Ensembl chr10:57,163,174...57,179,730
JBrowse link
G Prkcz protein kinase C, zeta increases activity
multiple interactions
EXP
ISO
Phosphatidic Acids results in increased activity of PRKCZ protein
Phosphatidic Acids results in increased phosphorylation of and results in increased activity of PRKCZ protein
CTD PMID:11978788 PMID:15255942 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Phosphatidic Acids results in increased expression of PTGS2 protein
Phosphatidic Acids results in increased expression of PTGS2 mRNA
CTD PMID:12872987 PMID:15210717 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO Phosphatidic Acids results in increased phosphorylation of and results in increased activity of RPS6KB1 protein CTD PMID:15255942 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 multiple interactions
increases activity
ISO MTOR protein affects the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein]; Sirolimus inhibits the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein]; wortmannin inhibits the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein] CTD PMID:12087098 NCBI chr 1:219,406,201...219,412,888
Ensembl chr 1:219,406,202...219,412,888
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Phosphatidic Acids results in increased phosphorylation of and affects the localization of STAT1 protein CTD PMID:16354768 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Phosphatidic Acids results in increased phosphorylation of and affects the localization of STAT3 protein CTD PMID:16354768 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Sts steroid sulfatase multiple interactions ISO Phosphatidic Acids promotes the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
ISO TNF protein inhibits the reaction [Carbachol results in increased abundance of Phosphatidic Acids]
Phosphatidic Acids results in increased secretion of TNF protein
CTD PMID:11245595 PMID:16354768 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
1,2-dioctanoyl-sn-glycero-3-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO dioctanoylphosphatidic acid results in increased expression of PTGS2 protein CTD PMID:11854442 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
dioleoyl phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plek pleckstrin multiple interactions ISO dioleoylphosphatidic acid analog promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased phosphorylation of PLEK protein] CTD PMID:8928743 NCBI chr14:100,151,518...100,184,192
Ensembl chr14:100,151,210...100,217,913
JBrowse link
phosphatidylethanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plek pleckstrin multiple interactions ISO phosphatidylethanol analog promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased phosphorylation of PLEK protein] CTD PMID:8928743 NCBI chr14:100,151,518...100,184,192
Ensembl chr14:100,151,210...100,217,913
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      biological role 19825
        osmolyte 2046
          glycerol 1772
            glycerolipid 263
              glycerophospholipid 200
                phosphatidic acid 26
                  1,2-diacyl-sn-glycerol 3-phosphate + 1
                  1,2-dioctadecanoyl-sn-glycerol-3-phosphate 0
                  1-decanoyl-2-stearoyl-sn-phosphatidic acid 0
                  1-stearoyl-2-arachidonoylphosphatidic acid 0
                  PA(16:0/18:1(11Z)) 0
                  PA(18:0/22:4) 0
                  PA(18:1(11Z)/18:1(11Z)) 0
                  PA(18:1(11Z)/18:1(9Z)) 0
                  didecanoylphosphatidic acid 0
                  dihexadecanoyl phosphatidic acid 0
                  dimyristoyl phosphatidic acid 0
                  phosphatidic acid (16:0/18:1) 0
                  phosphatidic acid 14:0 0
                  phosphatidic acid 16:0 0
                  phosphatidic acid 18:0 0
                  phosphatidic acid 18:3 0
                  phosphatidic acid 30:1 + 0
                  phosphatidic acid 32:5 + 0
                  phosphatidic acid 32:7 0
                  phosphatidic acid 36:2 + 1
                  phosphatidic acid 36:3 + 0
                  phosphatidic acid 36:4 0
                  phosphatidic acid 37:0 0
                  phosphatidic acid 38:0 0
                  phosphatidic acid 38:4 + 0
                  phosphatidic acid 39:1 0
                  phosphatidic acid 39:2 0
                  phosphatidic acid 39:5 0
                  phosphatidic acid 40:2 0
                  phosphatidic acid 40:6 + 0
                  phosphatidic acid 41:1 0
                  phosphatidic acid 41:2 0
                  phosphatidic acid 41:3 0
                  phosphatidic acid 41:5 0
                  phosphatidic acid 43:5 0
                  phosphatidic acid 44:6 0
                  phosphatidyl group 0
                  phosphatidylethanol + 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      chalcogen 19454
                        oxygen atom 19415
                          oxygen molecular entity 19415
                            hydroxides 19139
                              oxoacid 18273
                                pnictogen oxoacid 10308
                                  phosphorus oxoacid 9228
                                    phosphoric acids 7945
                                      phosphoric acid 7945
                                        phosphoric acid derivative 7624
                                          phosphate 7624
                                            organic phosphate 7623
                                              phospholipid 294
                                                glycerophospholipid 200
                                                  phosphatidic acid 26
                                                    1,2-diacyl-sn-glycerol 3-phosphate + 1
                                                    1,2-dioctadecanoyl-sn-glycerol-3-phosphate 0
                                                    1-decanoyl-2-stearoyl-sn-phosphatidic acid 0
                                                    1-stearoyl-2-arachidonoylphosphatidic acid 0
                                                    PA(16:0/18:1(11Z)) 0
                                                    PA(18:0/22:4) 0
                                                    PA(18:1(11Z)/18:1(11Z)) 0
                                                    PA(18:1(11Z)/18:1(9Z)) 0
                                                    didecanoylphosphatidic acid 0
                                                    dihexadecanoyl phosphatidic acid 0
                                                    dimyristoyl phosphatidic acid 0
                                                    phosphatidic acid (16:0/18:1) 0
                                                    phosphatidic acid 14:0 0
                                                    phosphatidic acid 16:0 0
                                                    phosphatidic acid 18:0 0
                                                    phosphatidic acid 18:3 0
                                                    phosphatidic acid 30:1 + 0
                                                    phosphatidic acid 32:5 + 0
                                                    phosphatidic acid 32:7 0
                                                    phosphatidic acid 36:2 + 1
                                                    phosphatidic acid 36:3 + 0
                                                    phosphatidic acid 36:4 0
                                                    phosphatidic acid 37:0 0
                                                    phosphatidic acid 38:0 0
                                                    phosphatidic acid 38:4 + 0
                                                    phosphatidic acid 39:1 0
                                                    phosphatidic acid 39:2 0
                                                    phosphatidic acid 39:5 0
                                                    phosphatidic acid 40:2 0
                                                    phosphatidic acid 40:6 + 0
                                                    phosphatidic acid 41:1 0
                                                    phosphatidic acid 41:2 0
                                                    phosphatidic acid 41:3 0
                                                    phosphatidic acid 41:5 0
                                                    phosphatidic acid 43:5 0
                                                    phosphatidic acid 44:6 0
                                                    phosphatidyl group 0
                                                    phosphatidylethanol + 1
paths to the root