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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phosphatidic acid
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Accession:CHEBI:16337 term browser browse the term
Definition:A derivative of glycerol in which one hydroxy group, commonly but not necessarily primary, is esterified with phosphoric acid and the other two are esterified with fatty acids.
Synonyms:related_synonym: 1,2-Diacyl-sn-glycerol 3-phosphate;   3-sn-Phosphatidate;   Formula=C5H7O8PR2;   Phosphatidate;   SMILES=OP(O)(=O)OCC(COC([*])=O)OC([*])=O;   phosphatidic acids
 alt_id: CHEBI:14795;   CHEBI:26023;   CHEBI:8122;   MESH:D010712
 xref: KEGG:C00416
 xref_mesh: MESH:D010712
 cyclic_relationship: is_conjugate_acid_of CHEBI:57739


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phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen increases abundance EXP AGT protein results in increased abundance of Phosphatidic Acids CTD PMID:14613874 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO
EXP		 alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Phosphatidic Acids results in increased phosphorylation of AKT1 protein]
R 59949 inhibits the reaction [Phosphatidic Acids results in increased phosphorylation of AKT1 protein]		 CTD PMID:15525798 PMID:16354768 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Avp arginine vasopressin increases abundance
multiple interactions		 EXP AVP protein results in increased abundance of Phosphatidic Acids
2-(4-amylcinnamoyl)amino-4-chlorobenzoic acid inhibits the reaction [AVP protein results in increased abundance of Phosphatidic Acids]		 CTD PMID:11356622 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases activity ISO Phosphatidic Acids results in increased activity of BGLAP protein CTD PMID:16857255 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Egf epidermal growth factor multiple interactions
increases abundance		 EXP 1-Butanol inhibits the reaction [EGF protein results in increased abundance of Phosphatidic Acids] CTD PMID:11134345 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase increases activity ISO Phosphatidic Acids results in increased activity of FGR protein CTD PMID:11078731 NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion		 ISO alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Phosphatidic Acids results in increased secretion of IL1B protein] CTD PMID:16354768 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion		 ISO alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Phosphatidic Acids results in increased secretion of IL6 protein] CTD PMID:16354768 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jak2 Janus kinase 2 increases phosphorylation ISO Phosphatidic Acids results in increased phosphorylation of JAK2 protein CTD PMID:16354768 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Phosphatidic Acids inhibits the reaction [Ethanol results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]; Phosphatidic Acids results in increased phosphorylation of and results in increased activity of MAPK1 protein; U 0126 inhibits the reaction [Phosphatidic Acids results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:18358832 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Phosphatidic Acids inhibits the reaction [Ethanol results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]; Phosphatidic Acids results in increased phosphorylation of and results in increased activity of MAPK3 protein; U 0126 inhibits the reaction [Phosphatidic Acids results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:18358832 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases activity
multiple interactions		 ISO Phosphatidic Acids results in increased activity of MMP2 protein
Quercetin inhibits the reaction [Phosphatidic Acids results in increased activity of MMP2 protein]		 CTD PMID:21867678 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases activity		 ISO MTOR protein affects the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein]
Phosphatidic Acids results in increased activity of MTOR protein		 CTD PMID:12087098 PMID:16537399 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions EXP [1-Butanol inhibits the reaction [PLD2 protein results in increased chemical synthesis of Phosphatidic Acids]] affects the reaction [PENK protein binds to and results in increased activity of OPRM1 protein] CTD PMID:14720217 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Penk proenkephalin multiple interactions EXP [1-Butanol inhibits the reaction [PLD2 protein results in increased chemical synthesis of Phosphatidic Acids]] affects the reaction [PENK protein binds to and results in increased activity of OPRM1 protein] CTD PMID:14720217 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Pld1 phospholipase D1 increases activity ISO Phosphatidic Acids results in increased activity of PLD1 protein CTD PMID:16857255 NCBI chr 2:110,849,205...111,047,692
Ensembl chr 2:110,893,608...111,047,692 		JBrowse link
G Pld2 phospholipase D2 multiple interactions EXP 1-Butanol inhibits the reaction [PLD2 protein results in increased chemical synthesis of Phosphatidic Acids]; [1-Butanol inhibits the reaction [PLD2 protein results in increased chemical synthesis of Phosphatidic Acids]] affects the reaction [PENK protein binds to and results in increased activity of OPRM1 protein] CTD PMID:14720217 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808 		JBrowse link
G Prkcz protein kinase C, zeta increases activity
multiple interactions		 EXP
ISO		 Phosphatidic Acids results in increased activity of PRKCZ protein
Phosphatidic Acids results in increased phosphorylation of and results in increased activity of PRKCZ protein		 CTD PMID:11978788 PMID:15255942 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Phosphatidic Acids results in increased expression of PTGS2 protein
Phosphatidic Acids results in increased expression of PTGS2 mRNA		 CTD PMID:12872987 PMID:15210717 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO Phosphatidic Acids results in increased phosphorylation of and results in increased activity of RPS6KB1 protein CTD PMID:15255942 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 multiple interactions
increases activity		 ISO MTOR protein affects the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein]; Sirolimus inhibits the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein]; wortmannin inhibits the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein] CTD PMID:12087098 NCBI chr 1:201,451,265...201,458,096
Ensembl chr 1:201,451,265...201,458,078 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Phosphatidic Acids results in increased phosphorylation of and affects the localization of STAT1 protein CTD PMID:16354768 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Phosphatidic Acids results in increased phosphorylation of and affects the localization of STAT3 protein CTD PMID:16354768 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Sts steroid sulfatase multiple interactions ISO Phosphatidic Acids promotes the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion		 ISO TNF protein inhibits the reaction [Carbachol results in increased abundance of Phosphatidic Acids]
Phosphatidic Acids results in increased secretion of TNF protein		 CTD PMID:11245595 PMID:16354768 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
1,2-dioctanoyl-sn-glycero-3-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO dioctanoylphosphatidic acid results in increased expression of PTGS2 protein CTD PMID:11854442 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
dioleoyl phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plek pleckstrin multiple interactions ISO dioleoylphosphatidic acid analog promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased phosphorylation of PLEK protein] CTD PMID:8928743 NCBI chr14:91,397,015...91,429,693
Ensembl chr14:91,397,019...91,454,131 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [1,2-oleoylphosphatidylcholine co-treated with dioleoylphosphatidic acid] binds to SOD1 protein; [1,2-oleoylphosphatidylcholine co-treated with dioleoylphosphatidic acid] binds to SOD1 protein mutant form; [1,2-oleoylphosphatidylcholine co-treated with dioleoylphosphatidic acid] promotes the reaction [SOD1 protein binds to SOD1 protein]; [1,2-oleoylphosphatidylcholine co-treated with dioleoylphosphatidic acid] promotes the reaction [SOD1 protein mutant form binds to SOD1 protein mutant form] CTD PMID:29649360 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
phosphatidylethanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plek pleckstrin multiple interactions ISO phosphatidylethanol analog promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased phosphorylation of PLEK protein] CTD PMID:8928743 NCBI chr14:91,397,015...91,429,693
Ensembl chr14:91,397,019...91,454,131 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        osmolyte 2053
          glycerol 1776
            glycerolipid 268
              glycerophospholipid 204
                phosphatidic acid 27
                  1,2-diacyl-sn-glycerol 3-phosphate + 1
                  1,2-dioctadecanoyl-sn-glycerol-3-phosphate 0
                  1-decanoyl-2-stearoyl-sn-phosphatidic acid 0
                  1-stearoyl-2-arachidonoylphosphatidic acid 0
                  PA(16:0/18:1(11Z)) 0
                  PA(18:0/22:4) 0
                  PA(18:1(11Z)/18:1(11Z)) 0
                  PA(18:1(11Z)/18:1(9Z)) 0
                  didecanoylphosphatidic acid 0
                  dihexadecanoyl phosphatidic acid 0
                  dimyristoyl phosphatidic acid 0
                  phosphatidic acid (16:0/18:1) 0
                  phosphatidic acid 14:0 0
                  phosphatidic acid 16:0 0
                  phosphatidic acid 18:0 0
                  phosphatidic acid 18:3 0
                  phosphatidic acid 30:1 + 0
                  phosphatidic acid 32:5 + 0
                  phosphatidic acid 32:7 0
                  phosphatidic acid 36:2 + 2
                  phosphatidic acid 36:3 + 0
                  phosphatidic acid 36:4 0
                  phosphatidic acid 37:0 0
                  phosphatidic acid 38:0 0
                  phosphatidic acid 38:4 + 0
                  phosphatidic acid 39:1 0
                  phosphatidic acid 39:2 0
                  phosphatidic acid 39:5 0
                  phosphatidic acid 40:2 0
                  phosphatidic acid 40:6 + 0
                  phosphatidic acid 41:1 0
                  phosphatidic acid 41:2 0
                  phosphatidic acid 41:3 0
                  phosphatidic acid 41:5 0
                  phosphatidic acid 43:5 0
                  phosphatidic acid 44:6 0
                  phosphatidyl group 0
                  phosphatidylethanol + 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      chalcogen 19450
                        oxygen atom 19423
                          oxygen molecular entity 19423
                            hydroxides 19158
                              oxoacid 18472
                                pnictogen oxoacid 10733
                                  phosphorus oxoacid 9728
                                    phosphoric acids 8536
                                      phosphoric acid 8536
                                        phosphoric acid derivative 8242
                                          phosphate 8242
                                            organic phosphate 8241
                                              phospholipid 304
                                                glycerophospholipid 204
                                                  phosphatidic acid 27
                                                    1,2-diacyl-sn-glycerol 3-phosphate + 1
                                                    1,2-dioctadecanoyl-sn-glycerol-3-phosphate 0
                                                    1-decanoyl-2-stearoyl-sn-phosphatidic acid 0
                                                    1-stearoyl-2-arachidonoylphosphatidic acid 0
                                                    PA(16:0/18:1(11Z)) 0
                                                    PA(18:0/22:4) 0
                                                    PA(18:1(11Z)/18:1(11Z)) 0
                                                    PA(18:1(11Z)/18:1(9Z)) 0
                                                    didecanoylphosphatidic acid 0
                                                    dihexadecanoyl phosphatidic acid 0
                                                    dimyristoyl phosphatidic acid 0
                                                    phosphatidic acid (16:0/18:1) 0
                                                    phosphatidic acid 14:0 0
                                                    phosphatidic acid 16:0 0
                                                    phosphatidic acid 18:0 0
                                                    phosphatidic acid 18:3 0
                                                    phosphatidic acid 30:1 + 0
                                                    phosphatidic acid 32:5 + 0
                                                    phosphatidic acid 32:7 0
                                                    phosphatidic acid 36:2 + 2
                                                    phosphatidic acid 36:3 + 0
                                                    phosphatidic acid 36:4 0
                                                    phosphatidic acid 37:0 0
                                                    phosphatidic acid 38:0 0
                                                    phosphatidic acid 38:4 + 0
                                                    phosphatidic acid 39:1 0
                                                    phosphatidic acid 39:2 0
                                                    phosphatidic acid 39:5 0
                                                    phosphatidic acid 40:2 0
                                                    phosphatidic acid 40:6 + 0
                                                    phosphatidic acid 41:1 0
                                                    phosphatidic acid 41:2 0
                                                    phosphatidic acid 41:3 0
                                                    phosphatidic acid 41:5 0
                                                    phosphatidic acid 43:5 0
                                                    phosphatidic acid 44:6 0
                                                    phosphatidyl group 0
                                                    phosphatidylethanol + 1
paths to the root