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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:L-cystine
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Accession:CHEBI:16283 term browser browse the term
Definition:The L-enantiomer of the sulfur-containing amino acid cystine.
Synonyms:exact_synonym: (2R,2'R)-3,3'-disulfanediylbis(2-aminopropanoic acid)
 related_synonym: (R,R)-3,3'-dithiobis(2-aminopropanoic acid);   (R-(R*,R*))-3,3'-Dithiobis(2-aminopropanoic acid);   3,3'-Dithiobis-L-alanine;   E921;   Formula=C6H12N2O4S2;   InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1;   InChIKey=LEVWYRKDKASIDU-IMJSIDKUSA-N;   L-Dicysteine;   L-alpha-Diamino-beta-dithiolactic acid;   SMILES=N[C@@H](CSSC[C@H](N)C(O)=O)C(O)=O;   beta,beta'-diamino-beta,beta'-dicarboxydiethyl disulfide;   beta,beta'-dithiodialanine;   bis(beta-amino-beta-carboxyethyl) disulfide;   oxidized L-cysteine
 alt_id: CHEBI:13097;   CHEBI:21278;   CHEBI:6209
 xref: Beilstein:1728094;   CAS:56-89-3;   DrugBank:DB00138;   Drug_Central:4130;   Gmelin:397179;   HMDB:HMDB0000192;   KEGG:C00491;   KEGG:D03636;   KNApSAcK:C00001352
 xref_mesh: MESH:D003553
 xref: PMID:14726201;   PMID:24264736;   PMID:24327171;   Reaxys:1728094
 cyclic_relationship: is_conjugate_acid_of CHEBI:63163;   is_enantiomer_of CHEBI:35494;   is_tautomer_of CHEBI:35491


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L-cystine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KYAT1 kynurenine aminotransferase 1 increases amination EXP KYAT1 protein results in increased amination of Cystine CTD PMID:22093698 NCBI chr 9:128,832,942...128,882,523
Ensembl chr 9:128,832,942...128,882,494
Ensembl chr 9:128,832,942...128,882,494 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein] CTD PMID:19850060 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein] CTD PMID:19850060 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G SLC3A1 solute carrier family 3 member 1 increases uptake
multiple interactions		 EXP SLC3A1 protein results in increased uptake of Cystine
[SLC3A1 protein co-treated with SLC7A9 protein] results in increased uptake of Cystine		 CTD PMID:14978168 PMID:18845132 NCBI chr 2:44,275,480...44,322,437
Ensembl chr 2:44,275,458...44,321,494 		JBrowse link
G SLC3A2 solute carrier family 3 member 2 multiple interactions ISO
EXP		 [SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine; Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]
[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine		 CTD PMID:19576933 PMID:22216172 NCBI chr11:62,856,109...62,888,860
Ensembl chr11:62,856,004...62,888,880 		JBrowse link
G SLC7A11 solute carrier family 7 member 11 multiple interactions ISO
EXP		 [SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine; Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]
[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine		 CTD PMID:19576933 PMID:22216172 NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349 		JBrowse link
G SLC7A9 solute carrier family 7 member 9 multiple interactions EXP [SLC3A1 protein co-treated with SLC7A9 protein] results in increased uptake of Cystine CTD PMID:14978168 NCBI chr19:32,830,511...32,869,767
Ensembl chr19:32,830,509...32,869,767 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      application 25172
        food additive 18326
          flour treatment agent 8380
            L-cystine 7
              L-cystine di-2-naphthylamide 0
              L-cystine mono-2-naphthylamide 0
              L-cystine residue 0
              L-cystinyl group 0
              L-cystyl group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    main group molecular entity 25834
                      s-block molecular entity 25166
                        hydrogen molecular entity 24765
                          hydrides 22965
                            inorganic hydride 20483
                              pnictogen hydride 20424
                                nitrogen hydride 20200
                                  azane 19942
                                    ammonia 19941
                                      organic amino compound 19941
                                        amino acid 17170
                                          alpha-amino acid 14690
                                            L-alpha-amino acid 13792
                                              serine family amino acid 6179
                                                L-cysteine 4100
                                                  L-cysteine derivative 4091
                                                    L-cystine 7
                                                      L-cystine di-2-naphthylamide 0
                                                      L-cystine mono-2-naphthylamide 0
                                                      L-cystine residue 0
                                                      L-cystinyl group 0
                                                      L-cystyl group 0
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