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G |
Atf4 |
activating transcription factor 4 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of ATF4 protein] |
CTD |
PMID:25451595 |
|
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Atf6 |
activating transcription factor 6 |
multiple interactions increases cleavage |
ISO |
Acetylcysteine inhibits the reaction [chloroacetic acid results in increased cleavage of ATF6 protein] |
CTD |
PMID:25451595 |
|
NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
ISO |
SB 203580 inhibits the reaction [chloroacetic acid results in increased expression of BAX mRNA] |
CTD |
PMID:23103613 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
ISO |
chloroacetic acid results in decreased expression of BCL2 mRNA SB 203580 inhibits the reaction [chloroacetic acid results in decreased expression of BCL2 mRNA] |
CTD |
PMID:23103613 |
|
NCBI chr13:22,689,783...22,853,920
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|
G |
Capn1 |
calpain 1 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of CAPN1 protein] |
CTD |
PMID:25451595 |
|
NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
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G |
Capn2 |
calpain 2 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of CAPN2 protein] |
CTD |
PMID:25451595 |
|
NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
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|
G |
Casp12 |
caspase 12 |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]; chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein; HSP90B1 protein promotes the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]; HSPA5 protein promotes the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein] |
CTD |
PMID:25451595 |
|
NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
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|
G |
Casp3 |
caspase 3 |
multiple interactions increases cleavage |
ISO |
chloroacetic acid results in increased cleavage of and results in increased activity of CASP3 protein; HSP90B1 protein promotes the reaction [chloroacetic acid results in increased cleavage of CASP3 protein]; HSPA5 protein promotes the reaction [chloroacetic acid results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [chloroacetic acid results in increased activity of CASP3 protein] |
CTD |
PMID:23103613 PMID:25451595 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp7 |
caspase 7 |
multiple interactions |
ISO |
chloroacetic acid results in increased cleavage of and results in increased activity of CASP7 protein; SB 203580 inhibits the reaction [chloroacetic acid results in increased activity of CASP7 protein] |
CTD |
PMID:23103613 |
|
NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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|
G |
Casp9 |
caspase 9 |
increases cleavage |
ISO |
chloroacetic acid results in increased cleavage of CASP9 protein |
CTD |
PMID:23103613 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of DDIT3 protein] chloroacetic acid results in increased expression of DDIT3 mRNA; chloroacetic acid results in increased expression of DDIT3 protein |
CTD |
PMID:25451595 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Eif2a |
eukaryotic translation initiation factor 2A |
increases phosphorylation multiple interactions |
ISO |
chloroacetic acid results in increased phosphorylation of EIF2A protein Acetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of EIF2A protein] |
CTD |
PMID:25451595 |
|
NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions increases phosphorylation |
ISO |
Acetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of EIF2AK3 protein] |
CTD |
PMID:25451595 |
|
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
multiple interactions increases phosphorylation |
ISO |
Acetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of ERN1 protein] |
CTD |
PMID:25451595 |
|
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
decreases expression |
ISO |
chloroacetic acid results in decreased expression of G6PC mRNA; chloroacetic acid results in decreased expression of G6PC protein |
CTD |
PMID:28189721 |
|
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
decreases activity |
EXP |
chloroacetic acid results in decreased activity of GAPDH protein |
CTD |
PMID:15720133 |
|
NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
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G |
Gk |
glycerol kinase |
decreases expression multiple interactions |
ISO |
chloroacetic acid results in decreased expression of GK mRNA [ethylene dichloride metabolite results in increased abundance of chloroacetic acid] which results in decreased expression of GK mRNA |
CTD |
PMID:28960355 |
|
NCBI chr X:50,162,089...50,238,707
Ensembl chr X:50,163,123...50,238,631
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP |
[vinylidene chloride co-treated with chloroacetic acid] results in increased expression of HMOX1 protein |
CTD |
PMID:9860887 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hsp90b1 |
heat shock protein 90 beta family member 1 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of HSP90B1 protein]; HSP90B1 protein promotes the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]; HSP90B1 protein promotes the reaction [chloroacetic acid results in increased cleavage of CASP3 protein] chloroacetic acid results in increased expression of HSP90B1 mRNA; chloroacetic acid results in increased expression of HSP90B1 protein |
CTD |
PMID:25451595 |
|
NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of HSPA5 protein]; HSPA5 protein promotes the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]; HSPA5 protein promotes the reaction [chloroacetic acid results in increased cleavage of CASP3 protein] chloroacetic acid results in increased expression of HSPA5 mRNA; chloroacetic acid results in increased expression of HSPA5 protein |
CTD |
PMID:25451595 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Hspd1 |
heat shock protein family D (Hsp60) member 1 |
multiple interactions |
EXP |
[vinylidene chloride co-treated with chloroacetic acid] results in increased expression of HSPD1 protein |
CTD |
PMID:9860887 |
|
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
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G |
Igf1 |
insulin-like growth factor 1 |
decreases expression |
ISO |
chloroacetic acid results in decreased expression of IGF1 mRNA; chloroacetic acid results in decreased expression of IGF1 protein |
CTD |
PMID:31520740 |
|
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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G |
Mbp |
myelin basic protein |
affects expression |
EXP |
chloroacetic acid affects the expression of MBP mRNA |
CTD |
PMID:22954530 |
|
NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
decreases expression |
ISO |
chloroacetic acid results in decreased expression of MCL1 mRNA |
CTD |
PMID:23103613 |
|
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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G |
Mir451a |
microRNA 451a |
multiple interactions increases expression |
ISO |
[ethylene dichloride metabolite results in increased abundance of chloroacetic acid] which results in increased expression of MIR451A mRNA chloroacetic acid results in increased expression of MIR451A mRNA |
CTD |
PMID:28960355 |
|
NCBI chr10:62,961,520...62,961,591
Ensembl chr10:62,961,520...62,961,591
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
chloroacetic acid results in increased cleavage of PARP1 protein |
CTD |
PMID:23103613 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pygl |
glycogen phosphorylase L |
decreases expression |
ISO |
chloroacetic acid results in decreased expression of PYGL mRNA; chloroacetic acid results in decreased expression of PYGL protein |
CTD |
PMID:28189721 |
|
NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310
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G |
Xbp1 |
X-box binding protein 1 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of XBP1 protein alternative form] chloroacetic acid results in increased expression of XBP1 mRNA alternative form; chloroacetic acid results in increased expression of XBP1 protein alternative form |
CTD |
PMID:25451595 |
|
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
increases expression |
ISO |
Iodoacetic Acid results in increased expression of AIFM1 mRNA |
CTD |
PMID:31693920 |
|
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
Iodoacetic Acid results in increased expression of BAX mRNA |
CTD |
PMID:31693920 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
Iodoacetic Acid results in decreased expression of BCL2 mRNA |
CTD |
PMID:31693920 |
|
NCBI chr13:22,689,783...22,853,920
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G |
Bcl2l10 |
Bcl2-like 10 |
decreases expression |
ISO |
Iodoacetic Acid results in decreased expression of BCL2L10 mRNA |
CTD |
PMID:31693920 |
|
NCBI chr 8:76,107,326...76,113,373
Ensembl chr 8:76,107,326...76,113,367
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
decreases expression |
ISO |
Iodoacetic Acid results in decreased expression of CCL2 mRNA |
CTD |
PMID:23397585 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccna2 |
cyclin A2 |
decreases expression |
ISO |
Iodoacetic Acid results in decreased expression of CCNA2 mRNA |
CTD |
PMID:31693920 |
|
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccnb1 |
cyclin B1 |
decreases expression |
ISO |
Iodoacetic Acid results in decreased expression of CCNB1 mRNA |
CTD |
PMID:31693920 |
|
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnd2 |
cyclin D2 |
decreases expression |
ISO |
Iodoacetic Acid results in decreased expression of CCND2 mRNA |
CTD |
PMID:31693920 |
|
NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
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G |
Ccne1 |
cyclin E1 |
decreases expression |
ISO |
Iodoacetic Acid results in decreased expression of CCNE1 mRNA |
CTD |
PMID:31693920 |
|
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Cdk4 |
cyclin-dependent kinase 4 |
increases expression |
ISO |
Iodoacetic Acid results in increased expression of CDK4 mRNA |
CTD |
PMID:31693920 |
|
NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
Iodoacetic Acid results in increased expression of CDKN1A mRNA |
CTD |
PMID:31693920 PMID:34453833 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cga |
glycoprotein hormones, alpha polypeptide |
decreases expression |
ISO |
Iodoacetic Acid results in decreased expression of CGA mRNA |
CTD |
PMID:34453833 |
|
NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191
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G |
Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
increases expression |
ISO |
Iodoacetic Acid results in increased expression of CYP11A1 mRNA |
CTD |
PMID:31693920 |
|
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
decreases expression |
ISO |
Iodoacetic Acid results in decreased expression of CYP17A1 mRNA |
CTD |
PMID:31693920 |
|
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
decreases expression |
ISO |
Iodoacetic Acid results in decreased expression of CYP19A1 mRNA |
CTD |
PMID:31693920 |
|
NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
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G |
Esr1 |
estrogen receptor 1 |
decreases expression |
ISO |
Iodoacetic Acid results in decreased expression of ESR1 mRNA |
CTD |
PMID:31693920 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Fshb |
follicle stimulating hormone subunit beta |
increases expression |
ISO |
Iodoacetic Acid results in increased expression of FSHB mRNA |
CTD |
PMID:34453833 |
|
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
Grk1 |
G protein-coupled receptor kinase 1 |
multiple interactions |
ISO |
[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA; Octreotide affects the reaction [SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA]]; Octreotide inhibits the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA]; SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA] |
CTD |
PMID:18624922 |
|
NCBI chr16:76,122,501...76,135,792
Ensembl chr16:76,123,842...76,135,792
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G |
Hras |
HRas proto-oncogene, GTPase |
increases response to substance |
ISO |
HRAS protein modified form results in increased susceptibility to Iodoacetic Acid |
CTD |
PMID:19923925 |
|
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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G |
Hsd17b1 |
hydroxysteroid (17-beta) dehydrogenase 1 |
decreases expression |
ISO |
Iodoacetic Acid results in decreased expression of HSD17B1 mRNA |
CTD |
PMID:31693920 |
|
NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927
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G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
increases expression |
ISO |
Iodoacetic Acid results in increased expression of HSD3B1 mRNA |
CTD |
PMID:31693920 |
|
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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G |
Id2 |
inhibitor of DNA binding 2 |
decreases expression |
ISO |
Iodoacetic Acid results in decreased expression of ID2 mRNA |
CTD |
PMID:23397585 |
|
NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
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G |
Id3 |
inhibitor of DNA binding 3, HLH protein |
decreases expression |
ISO |
Iodoacetic Acid results in decreased expression of ID3 mRNA |
CTD |
PMID:23397585 |
|
NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
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G |
Kiss1 |
KiSS-1 metastasis-suppressor |
increases expression |
ISO |
Iodoacetic Acid results in increased expression of KISS1 mRNA |
CTD |
PMID:34453833 |
|
NCBI chr13:44,774,823...44,780,707
Ensembl chr13:44,774,823...44,780,612
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G |
Klf9 |
Kruppel-like factor 9 |
decreases expression |
ISO |
Iodoacetic Acid results in decreased expression of KLF9 mRNA |
CTD |
PMID:23397585 |
|
NCBI chr 1:220,700,108...220,725,029
Ensembl chr 1:220,700,108...220,725,037
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G |
Lhb |
luteinizing hormone subunit beta |
decreases expression |
ISO |
Iodoacetic Acid results in decreased expression of LHB mRNA |
CTD |
PMID:34453833 |
|
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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|
G |
Mki67 |
marker of proliferation Ki-67 |
decreases expression |
ISO |
Iodoacetic Acid results in decreased expression of MKI67 mRNA |
CTD |
PMID:31693920 |
|
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases expression |
ISO |
Iodoacetic Acid results in increased expression of PARP1 protein modified form |
CTD |
PMID:25944804 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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|
G |
Rgs1 |
regulator of G-protein signaling 1 |
multiple interactions |
ISO |
[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of RGS1 mRNA; Octreotide inhibits the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of RGS1 mRNA]; SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of RGS1 mRNA] |
CTD |
PMID:18624922 |
|
NCBI chr13:56,018,529...56,022,939
Ensembl chr13:56,018,554...56,022,984
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|
G |
Sstr1 |
somatostatin receptor 1 |
multiple interactions |
ISO |
Octreotide affects the reaction [SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA]]; SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA]; SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of RGS1 mRNA] |
CTD |
PMID:18624922 |
|
NCBI chr 6:75,832,292...75,836,806
Ensembl chr 6:75,832,530...75,836,802
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|
G |
Star |
steroidogenic acute regulatory protein |
increases expression |
ISO |
Iodoacetic Acid results in increased expression of STAR mRNA |
CTD |
PMID:31693920 |
|
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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|
|
G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases chemical synthesis multiple interactions increases abundance |
ISO |
CYP3A4 protein results in increased chemical synthesis of 2-chloro-N-(2,6-diethylphenyl)acetamide [CYP3A4 protein results in increased metabolism of alachlor] which results in increased abundance of 2-chloro-N-(2,6-diethylphenyl)acetamide CYP3A4 protein results in increased abundance of 2-chloro-N-(2,6-diethylphenyl)acetamide |
CTD |
PMID:10475613 PMID:18273908 |
|
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
|
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