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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:haloacetic acid
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Accession:CHEBI:16277 term browser browse the term
Definition:A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens has been replaced by a halogen atom.
Synonyms:related_synonym: Formula=C2H3O2X;   SMILES=OC(=O)C*
 alt_id: CHEBI:14385;   CHEBI:24467;   CHEBI:5608
 xref: KEGG:C01812
 cyclic_relationship: is_conjugate_acid_of CHEBI:85638

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chloroacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of ATF4 protein] CTD PMID:25451595 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions
increases cleavage		 ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased cleavage of ATF6 protein] CTD PMID:25451595 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO SB 203580 inhibits the reaction [chloroacetic acid results in increased expression of BAX mRNA] CTD PMID:23103613 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO chloroacetic acid results in decreased expression of BCL2 mRNA
SB 203580 inhibits the reaction [chloroacetic acid results in decreased expression of BCL2 mRNA]		 CTD PMID:23103613 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Capn1 calpain 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of CAPN1 protein] CTD PMID:25451595 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177 		JBrowse link
G Capn2 calpain 2 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of CAPN2 protein] CTD PMID:25451595 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969 		JBrowse link
G Casp12 caspase 12 multiple interactions ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]; chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein; HSP90B1 protein promotes the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]; HSPA5 protein promotes the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein] CTD PMID:25451595 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage		 ISO chloroacetic acid results in increased cleavage of and results in increased activity of CASP3 protein; HSP90B1 protein promotes the reaction [chloroacetic acid results in increased cleavage of CASP3 protein]; HSPA5 protein promotes the reaction [chloroacetic acid results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [chloroacetic acid results in increased activity of CASP3 protein] CTD PMID:23103613 PMID:25451595 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO chloroacetic acid results in increased cleavage of and results in increased activity of CASP7 protein; SB 203580 inhibits the reaction [chloroacetic acid results in increased activity of CASP7 protein] CTD PMID:23103613 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO chloroacetic acid results in increased cleavage of CASP9 protein CTD PMID:23103613 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of DDIT3 protein]
chloroacetic acid results in increased expression of DDIT3 mRNA; chloroacetic acid results in increased expression of DDIT3 protein		 CTD PMID:25451595 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation
multiple interactions		 ISO chloroacetic acid results in increased phosphorylation of EIF2A protein
Acetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of EIF2A protein]		 CTD PMID:25451595 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation		 ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of EIF2AK3 protein] CTD PMID:25451595 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
increases phosphorylation		 ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of ERN1 protein] CTD PMID:25451595 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO chloroacetic acid results in decreased expression of G6PC mRNA; chloroacetic acid results in decreased expression of G6PC protein CTD PMID:28189721 NCBI chr10:86,307,400...86,318,766 JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase decreases activity EXP chloroacetic acid results in decreased activity of GAPDH protein CTD PMID:15720133 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gk glycerol kinase decreases expression
multiple interactions		 ISO chloroacetic acid results in decreased expression of GK mRNA
[ethylene dichloride metabolite results in increased abundance of chloroacetic acid] which results in decreased expression of GK mRNA		 CTD PMID:28960355 NCBI chr  X:50,162,089...50,238,707
Ensembl chr  X:50,163,123...50,238,631 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP [vinylidene chloride co-treated with chloroacetic acid] results in increased expression of HMOX1 protein CTD PMID:9860887 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of HSP90B1 protein]; HSP90B1 protein promotes the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]; HSP90B1 protein promotes the reaction [chloroacetic acid results in increased cleavage of CASP3 protein]
chloroacetic acid results in increased expression of HSP90B1 mRNA; chloroacetic acid results in increased expression of HSP90B1 protein		 CTD PMID:25451595 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of HSPA5 protein]; HSPA5 protein promotes the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]; HSPA5 protein promotes the reaction [chloroacetic acid results in increased cleavage of CASP3 protein]
chloroacetic acid results in increased expression of HSPA5 mRNA; chloroacetic acid results in increased expression of HSPA5 protein		 CTD PMID:25451595 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions EXP [vinylidene chloride co-treated with chloroacetic acid] results in increased expression of HSPD1 protein CTD PMID:9860887 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO chloroacetic acid results in decreased expression of IGF1 mRNA; chloroacetic acid results in decreased expression of IGF1 protein CTD PMID:31520740 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Mbp myelin basic protein affects expression EXP chloroacetic acid affects the expression of MBP mRNA CTD PMID:22954530 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO chloroacetic acid results in decreased expression of MCL1 mRNA CTD PMID:23103613 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mir451a microRNA 451a multiple interactions
increases expression		 ISO [ethylene dichloride metabolite results in increased abundance of chloroacetic acid] which results in increased expression of MIR451A mRNA
chloroacetic acid results in increased expression of MIR451A mRNA		 CTD PMID:28960355 NCBI chr10:62,961,520...62,961,591
Ensembl chr10:62,961,520...62,961,591 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO chloroacetic acid results in increased cleavage of PARP1 protein CTD PMID:23103613 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pygl glycogen phosphorylase L decreases expression ISO chloroacetic acid results in decreased expression of PYGL mRNA; chloroacetic acid results in decreased expression of PYGL protein CTD PMID:28189721 NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of XBP1 protein alternative form]
chloroacetic acid results in increased expression of XBP1 mRNA alternative form; chloroacetic acid results in increased expression of XBP1 protein alternative form		 CTD PMID:25451595 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
iodoacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO Iodoacetic Acid results in increased expression of AIFM1 mRNA CTD PMID:31693920 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Iodoacetic Acid results in increased expression of BAX mRNA CTD PMID:31693920 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Iodoacetic Acid results in decreased expression of BCL2 mRNA CTD PMID:31693920 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l10 BCL2 like 10 decreases expression ISO Iodoacetic Acid results in decreased expression of BCL2L10 mRNA CTD PMID:31693920 NCBI chr 8:76,107,326...76,113,373
Ensembl chr 8:76,107,326...76,113,367 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Iodoacetic Acid results in decreased expression of CCL2 mRNA CTD PMID:23397585 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Iodoacetic Acid results in decreased expression of CCNA2 mRNA CTD PMID:31693920 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Iodoacetic Acid results in decreased expression of CCNB1 mRNA CTD PMID:31693920 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO Iodoacetic Acid results in decreased expression of CCND2 mRNA CTD PMID:31693920 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Iodoacetic Acid results in decreased expression of CCNE1 mRNA CTD PMID:31693920 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression ISO Iodoacetic Acid results in increased expression of CDK4 mRNA CTD PMID:31693920 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Iodoacetic Acid results in increased expression of CDKN1A mRNA CTD PMID:31693920 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression ISO Iodoacetic Acid results in increased expression of CYP11A1 mRNA CTD PMID:31693920 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO Iodoacetic Acid results in decreased expression of CYP17A1 mRNA CTD PMID:31693920 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression ISO Iodoacetic Acid results in decreased expression of CYP19A1 mRNA CTD PMID:31693920 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO Iodoacetic Acid results in decreased expression of ESR1 mRNA CTD PMID:31693920 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Grk1 G protein-coupled receptor kinase 1 multiple interactions ISO [Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA; Octreotide affects the reaction [SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA]]; Octreotide inhibits the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA]; SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA] CTD PMID:18624922 NCBI chr16:76,122,501...76,135,792
Ensembl chr16:76,123,842...76,135,792 		JBrowse link
G Hras HRas proto-oncogene, GTPase increases response to substance ISO HRAS protein modified form results in increased susceptibility to Iodoacetic Acid CTD PMID:19923925 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 decreases expression ISO Iodoacetic Acid results in decreased expression of HSD17B1 mRNA CTD PMID:31693920 NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 increases expression ISO Iodoacetic Acid results in increased expression of HSD3B1 mRNA CTD PMID:31693920 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression ISO Iodoacetic Acid results in decreased expression of ID2 mRNA CTD PMID:23397585 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400 		JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein decreases expression ISO Iodoacetic Acid results in decreased expression of ID3 mRNA CTD PMID:23397585 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349 		JBrowse link
G Klf9 Kruppel-like factor 9 decreases expression ISO Iodoacetic Acid results in decreased expression of KLF9 mRNA CTD PMID:23397585 NCBI chr 1:220,700,108...220,725,029
Ensembl chr 1:220,700,108...220,725,037 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Iodoacetic Acid results in decreased expression of MKI67 mRNA CTD PMID:31693920 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO Iodoacetic Acid results in increased expression of PARP1 protein modified form CTD PMID:25944804 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Rgs1 regulator of G-protein signaling 1 multiple interactions ISO [Nitrogen co-treated with Iodoacetic Acid] results in increased expression of RGS1 mRNA; Octreotide inhibits the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of RGS1 mRNA]; SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of RGS1 mRNA] CTD PMID:18624922 NCBI chr13:56,018,529...56,022,939
Ensembl chr13:56,018,554...56,022,984 		JBrowse link
G Sstr1 somatostatin receptor 1 multiple interactions ISO Octreotide affects the reaction [SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA]]; SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA]; SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of RGS1 mRNA] CTD PMID:18624922 NCBI chr 6:75,832,292...75,836,806
Ensembl chr 6:75,832,530...75,836,802 		JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO Iodoacetic Acid results in increased expression of STAR mRNA CTD PMID:31693920 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
N-(2,6-diethylphenyl)-2-chloroacetamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases chemical synthesis
multiple interactions
increases abundance		 ISO CYP3A4 protein results in increased chemical synthesis of 2-chloro-N-(2,6-diethylphenyl)acetamide
[CYP3A4 protein results in increased metabolism of alachlor] which results in increased abundance of 2-chloro-N-(2,6-diethylphenyl)acetamide
CYP3A4 protein results in increased abundance of 2-chloro-N-(2,6-diethylphenyl)acetamide		 CTD PMID:10475613 PMID:18273908 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        food additive 15111
          food acidity regulator 11725
            acetic acid 10854
              haloacetic acid 53
                chloroacetic acid + 29
                fluoroacetic acid + 0
                iodoacetic acid 27
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        monocarboxylic acid 17632
                                          acetic acid 10854
                                            haloacetic acid 53
                                              chloroacetic acid + 29
                                              fluoroacetic acid + 0
                                              iodoacetic acid 27
paths to the root