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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-(trimethylammonio)butanoate
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Accession:CHEBI:16244 term browser browse the term
Definition:An amino-acid betaine gamma-aminobutyric acid zwitterion in which all of the hydrogens attached to the nitrogen are replaced by methyl groups.
Synonyms:related_synonym: 3-Dehydroxycarnitine;   4-(N-trimethylamino)butyrate;   4-(trimethylamino)butanoate;   4-butyrobetaine;   Actinine;   Formula=C7H15NO2;   InChI=1S/C7H15NO2/c1-8(2,3)6-4-5-7(9)10/h4-6H2,1-3H3;   InChIKey=JHPNVNIEXXLNTR-UHFFFAOYSA-N;   SMILES=C[N+](C)(C)CCCC([O-])=O;   butyrobetaine;   deoxycarnitine;   gamma-Butyrobetain;   gamma-butyrobetaine
 alt_id: CHEBI:12047;   CHEBI:20484
 xref: Beilstein:3538300;   CAS:407-64-7;   ECMDB:ECMDB21336;   HMDB:HMDB0006831
 xref_mesh: MESH:C002889
 xref: MetaCyc:GAMMA-BUTYROBETAINE;   PMID:3148329;   PMID:398096;   Reaxys:3538300
 cyclic_relationship: is_conjugate_base_of CHEBI:1941


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4-(trimethylammonio)butanoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bbox1 gamma-butyrobetaine hydroxylase 1 multiple interactions ISO [BBOX1 protein co-treated with Ketoglutaric Acids] results in increased metabolism of gamma-butyrobetaine CTD PMID:21439360 NCBI chr 2:110,094,401...110,145,158
Ensembl chr 2:110,093,042...110,144,905 		JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial multiple interactions
increases abundance		 EXP Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of gamma-butyrobetaine] CTD PMID:27469509 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      biological role 22178
        biochemical role 21449
          metabolite 21397
            butyrate 101
              gamma-aminobutyrate 2
                4-(trimethylammonio)butanoate 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    main group molecular entity 22120
                      s-block molecular entity 21717
                        hydrogen molecular entity 21634
                          hydrides 20777
                            inorganic hydride 18692
                              pnictogen hydride 18672
                                nitrogen hydride 18540
                                  ammonium 8217
                                    ammonium ion derivative 8212
                                      quaternary ammonium ion 5407
                                        quaternary nitrogen compound 886
                                          ammonium betaine 360
                                            amino-acid betaine 260
                                              4-(trimethylammonio)butanoate 2
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