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G |
Alas1 |
aminolevulinic acid synthase 1 |
increases activity |
ISO |
pyridine results in increased activity of ALAS1 protein |
CTD |
PMID:10413312 |
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NCBI chr 9:106,110,654...106,125,153
Ensembl chr 9:106,110,654...106,125,853
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G |
Cd86 |
CD86 antigen |
increases expression |
ISO |
pyridine results in increased expression of CD86 protein |
CTD |
PMID:19665512 |
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NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions increases expression increases activity |
ISO EXP |
CYP2E1 protein promotes the reaction [pyridine results in increased expression of CYP1A1 mRNA]; Dimethyl Sulfoxide inhibits the reaction [CYP2E1 protein promotes the reaction [pyridine results in increased expression of CYP1A1 mRNA]] pyridine results in increased expression of CYP1A1 mRNA; pyridine results in increased expression of CYP1A1 protein pyridine results in increased activity of CYP1A1 protein |
CTD |
PMID:1857340 PMID:2241968 PMID:7493548 PMID:7511897 PMID:10413312 PMID:10463385 PMID:11849738 PMID:12147272 More...
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NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression increases activity |
ISO |
pyridine results in increased expression of CYP1A2 mRNA; pyridine results in increased expression of CYP1A2 protein pyridine results in increased activity of CYP1A2 protein |
CTD |
PMID:1857340 PMID:7493548 PMID:10413312 PMID:10463385 |
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NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
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G |
Cyp2b13 |
cytochrome P450, family 2, subfamily b, polypeptide 13 |
multiple interactions increases expression affects activity increases activity |
ISO |
pyridine promotes the reaction [ciprofibrate results in increased expression of CYP2B2 protein] pyridine results in increased expression of CYP2B2 mRNA; pyridine results in increased expression of CYP2B2 protein pyridine affects the activity of CYP2B2 protein pyridine results in increased activity of CYP2B2 protein |
CTD |
PMID:1610360 PMID:7587954 PMID:8246169 PMID:11181506 |
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NCBI chr 7:25,760,813...25,795,622
Ensembl chr 7:25,760,922...25,795,622
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions increases activity increases expression decreases activity |
ISO |
CYP2E1 protein promotes the reaction [pyridine results in increased expression of CYP1A1 mRNA]; Dimethyl Sulfoxide inhibits the reaction [CYP2E1 protein promotes the reaction [pyridine results in increased expression of CYP1A1 mRNA]] pyridine results in increased activity of CYP2E1 protein pyridine results in increased expression of CYP2E1 mRNA; pyridine results in increased expression of CYP2E1 protein [pyridine co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 mRNA; [pyridine co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 protein; [pyridine co-treated with Methylcholanthrene] results in increased activity of CYP2E1 protein; [pyridine co-treated with Methylcholanthrene] results in increased expression of CYP2E1 protein; Cycloheximide inhibits the reaction [pyridine results in increased activity of CYP2E1 protein]; Cycloheximide inhibits the reaction [pyridine results in increased expression of CYP2E1 protein]; Ditiocarb inhibits the reaction [pyridine results in increased activity of CYP2E1 protein]; INS protein affects the reaction [pyridine results in increased expression of CYP2E1 protein]; pyridine promotes the reaction [ciprofibrate results in increased expression of CYP2E1 protein]; pyridine promotes the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] pyridine results in decreased activity of CYP2E1 protein |
CTD |
PMID:1379807 PMID:1610360 PMID:1968335 PMID:2241968 PMID:7587954 PMID:8074729 PMID:8246169 PMID:8734847 PMID:9618253 PMID:10215695 PMID:11181506 PMID:12147272 PMID:12464242 PMID:12919724 PMID:23211455 More...
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NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
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G |
Fos |
FBJ osteosarcoma oncogene |
multiple interactions |
ISO |
pyridine promotes the reaction [Carbon Tetrachloride results in increased expression of FOS mRNA] |
CTD |
PMID:8825185 |
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NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
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G |
Grin2b |
glutamate receptor, ionotropic, NMDA2B (epsilon 2) |
multiple interactions |
ISO |
pyridine analog binds to and results in decreased activity of GRIN2B protein |
CTD |
PMID:17768047 |
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NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509
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G |
Hmox1 |
heme oxygenase 1 |
increases activity increases expression |
ISO |
pyridine results in increased activity of HMOX1 protein pyridine results in increased expression of HMOX1 mRNA; pyridine results in increased expression of HMOX1 protein |
CTD |
PMID:10413312 |
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NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
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G |
Hsf1 |
heat shock factor 1 |
increases activity |
ISO |
pyridine results in increased activity of HSF1 protein |
CTD |
PMID:34170685 |
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NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113
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G |
Ins2 |
insulin II |
multiple interactions |
ISO |
INS protein affects the reaction [pyridine results in increased expression of CYP2B1 mRNA]; INS protein affects the reaction [pyridine results in increased expression of CYP2B1 protein]; INS protein affects the reaction [pyridine results in increased expression of CYP2E1 protein] |
CTD |
PMID:10215695 |
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NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118
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G |
Jun |
jun proto-oncogene |
multiple interactions |
ISO |
pyridine promotes the reaction [Carbon Tetrachloride results in increased expression of JUN mRNA] |
CTD |
PMID:8825185 |
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NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
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G |
Kcnh2 |
potassium voltage-gated channel, subfamily H (eag-related), member 2 |
affects binding |
ISO |
pyridine analog binds to KCNH2 protein |
CTD |
PMID:17768047 |
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NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
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G |
Tdo2 |
tryptophan 2,3-dioxygenase |
multiple interactions |
ISO |
Heme promotes the reaction [pyridine results in increased activity of TDO2 protein] |
CTD |
PMID:10413312 |
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NCBI chr 3:81,865,719...81,883,035
Ensembl chr 3:81,864,397...81,883,509
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
[Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased cleavage of CASP3 protein |
CTD |
PMID:17327230 |
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NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
[Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased cleavage of CASP9 protein |
CTD |
PMID:17327230 |
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NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
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G |
Cdkn1a |
cyclin dependent kinase inhibitor 1A |
multiple interactions |
ISO |
[Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased expression of CDKN1A protein |
CTD |
PMID:17327230 |
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NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
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G |
Cycs |
cytochrome c, somatic |
multiple interactions |
ISO |
[Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which affects the localization of CYCS protein |
CTD |
PMID:17327230 |
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NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518
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G |
Hrh1 |
histamine receptor H1 |
multiple interactions |
EXP ISO |
2-(2-aminoethyl)pyridine binds to and results in increased activity of HRH1 protein; HRH1 protein promotes the reaction [2-(2-aminoethyl)pyridine results in increased expression of IL6 mRNA] |
CTD |
PMID:9657254 PMID:16143415 |
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NCBI chr 6:114,374,897...114,459,432
Ensembl chr 6:114,374,897...114,460,257
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G |
Il6 |
interleukin 6 |
increases expression multiple interactions |
EXP |
2-(2-aminoethyl)pyridine results in increased expression of IL6 mRNA HRH1 protein promotes the reaction [2-(2-aminoethyl)pyridine results in increased expression of IL6 mRNA] |
CTD |
PMID:9657254 |
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NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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G |
Sod1 |
superoxide dismutase 1, soluble |
multiple interactions |
ISO |
SOD1 protein results in decreased susceptibility to [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] |
CTD |
PMID:17327230 |
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NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
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G |
Trp53 |
transformation related protein 53 |
multiple interactions |
ISO |
[Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased expression of TP53 protein |
CTD |
PMID:17327230 |
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NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
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G |
Glud1 |
glutamate dehydrogenase 1 |
decreases activity multiple interactions |
EXP |
dipicolinic acid results in decreased activity of GLUD1 protein dipicolinic acid inhibits the reaction [[GLUD1 protein co-treated with Ketoglutaric Acids co-treated with NADP co-treated with Aminooxyacetic Acid] affects the reaction [Carbon Tetrachloride affects the abundance of Ammonia]] |
CTD |
PMID:26639393 |
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NCBI chr14:34,032,684...34,066,990
Ensembl chr14:34,032,684...34,067,222
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G |
Mapt |
microtubule-associated protein tau |
multiple interactions |
ISO |
dipicolinic acid promotes the reaction [MAPT protein binds to MAPT protein] |
CTD |
PMID:31678113 |
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NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
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G |
Acmsd |
amino carboxymuconate semialdehyde decarboxylase |
affects abundance |
ISO |
ACMSD protein affects the abundance of Quinolinic Acid |
CTD |
PMID:17896587 |
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NCBI chr 1:127,657,149...127,695,723
Ensembl chr 1:127,657,150...127,695,715
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G |
Ahr |
aryl-hydrocarbon receptor |
increases activity |
ISO |
Quinolinic Acid results in increased activity of AHR protein |
CTD |
PMID:28336214 |
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NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
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G |
Bax |
BCL2-associated X protein |
increases expression multiple interactions |
ISO |
Quinolinic Acid results in increased expression of BAX mRNA [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA] |
CTD |
PMID:30130594 |
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NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
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G |
Bcl2 |
B cell leukemia/lymphoma 2 |
multiple interactions decreases expression |
ISO |
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA]; naringin inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA] |
CTD |
PMID:30130594 |
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NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
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G |
Bdnf |
brain derived neurotrophic factor |
increases expression |
ISO |
Quinolinic Acid results in increased expression of BDNF mRNA |
CTD |
PMID:15698628 |
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NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
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G |
Casp3 |
caspase 3 |
multiple interactions increases activity increases expression |
ISO |
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; Gallic Acid inhibits the reaction [Quinolinic Acid results in increased activity of CASP3 protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; wedelolactone inhibits the reaction [Quinolinic Acid results in increased activity of CASP3 protein] |
CTD |
PMID:29981346 PMID:30130594 |
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NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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G |
Cat |
catalase |
multiple interactions decreases activity decreases expression |
ISO |
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [pioglitazone inhibits the reaction [Quinolinic Acid results in decreased activity of CAT protein]]; nimesulide inhibits the reaction [Quinolinic Acid results in decreased expression of CAT protein]; pioglitazone inhibits the reaction [Quinolinic Acid results in decreased activity of CAT protein]; rofecoxib inhibits the reaction [Quinolinic Acid results in decreased expression of CAT protein] |
CTD |
PMID:20043943 PMID:20450929 |
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NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
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G |
Chat |
choline acetyltransferase |
multiple interactions decreases activity |
ISO |
Dizocilpine Maleate inhibits the reaction [Quinolinic Acid results in decreased activity of CHAT protein] |
CTD |
PMID:2976130 |
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NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946
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G |
Cp |
ceruloplasmin |
multiple interactions |
ISO |
[Copper Sulfate co-treated with Quinolinic Acid] results in increased activity of CP protein |
CTD |
PMID:12899943 |
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NCBI chr 3:20,011,097...20,063,914
Ensembl chr 3:20,011,218...20,063,309
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G |
Dpp3 |
dipeptidylpeptidase 3 |
multiple interactions |
ISO |
Quinolinic Acid promotes the reaction [DPP3 protein binds to KEAP1 protein] |
CTD |
PMID:30876764 |
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NCBI chr19:4,957,257...4,978,315
Ensembl chr19:4,957,257...4,978,315
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G |
Drd1 |
dopamine receptor D1 |
decreases expression |
ISO |
Quinolinic Acid results in decreased expression of DRD1 protein |
CTD |
PMID:12207953 |
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NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724
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G |
Drd2 |
dopamine receptor D2 |
increases expression |
ISO |
Quinolinic Acid results in increased expression of DRD2 protein |
CTD |
PMID:12207953 |
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NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477
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G |
Eif2ak2 |
eukaryotic translation initiation factor 2-alpha kinase 2 |
multiple interactions |
ISO |
GW 506033X inhibits the reaction [Quinolinic Acid results in increased expression of and results in increased cleavage of EIF2AK2 protein]; Quinolinic Acid results in increased expression of and results in increased cleavage of EIF2AK2 protein |
CTD |
PMID:24211709 |
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NCBI chr17:79,157,933...79,190,001
Ensembl chr17:79,159,993...79,190,002
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G |
Eif2s1 |
eukaryotic translation initiation factor 2, subunit 1 alpha |
increases phosphorylation multiple interactions |
ISO |
Quinolinic Acid results in increased phosphorylation of EIF2S1 protein [Quinolinic Acid co-treated with GW 506033X] results in increased phosphorylation of EIF2S1 protein |
CTD |
PMID:24211709 |
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NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784
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G |
Fgf1 |
fibroblast growth factor 1 |
decreases secretion |
EXP ISO |
Quinolinic Acid results in decreased secretion of FGF1 protein |
CTD |
PMID:16392031 |
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NCBI chr18:38,971,725...39,062,532
Ensembl chr18:38,971,726...39,062,525
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G |
Fos |
FBJ osteosarcoma oncogene |
increases expression |
ISO |
Quinolinic Acid results in increased expression of FOS mRNA |
CTD |
PMID:15698628 |
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NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
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G |
G6pdx |
glucose-6-phosphate dehydrogenase X-linked |
increases activity |
ISO |
Quinolinic Acid results in increased activity of G6PD protein |
CTD |
PMID:30876764 |
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NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
ISO |
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]; Gallic Acid inhibits the reaction [Quinolinic Acid results in increased expression of IL1B protein]; GW 506033X inhibits the reaction [Quinolinic Acid results in increased expression of IL1B protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]; wedelolactone inhibits the reaction [Quinolinic Acid results in increased expression of IL1B protein] Quinolinic Acid results in increased expression of IL1B mRNA; Quinolinic Acid results in increased expression of IL1B protein |
CTD |
PMID:24211709 PMID:29981346 PMID:30130594 |
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NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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G |
Il6 |
interleukin 6 |
multiple interactions increases expression |
ISO |
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; Gallic Acid inhibits the reaction [Quinolinic Acid results in increased expression of IL6 protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; wedelolactone inhibits the reaction [Quinolinic Acid results in increased expression of IL6 protein] Quinolinic Acid results in increased expression of IL6 mRNA; Quinolinic Acid results in increased expression of IL6 protein |
CTD |
PMID:29981346 PMID:30130594 |
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NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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G |
Keap1 |
kelch-like ECH-associated protein 1 |
multiple interactions |
ISO |
Quinolinic Acid promotes the reaction [DPP3 protein binds to KEAP1 protein]; Quinolinic Acid promotes the reaction [SQSTM1 protein binds to KEAP1 protein]; Quinolinic Acid results in increased expression of and affects the localization of KEAP1 protein |
CTD |
PMID:30876764 |
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NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657
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G |
Mapt |
microtubule-associated protein tau |
multiple interactions |
ISO |
Quinolinic Acid promotes the reaction [MAPT protein binds to MAPT protein] |
CTD |
PMID:31678113 |
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NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
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G |
Nfe2l2 |
nuclear factor, erythroid derived 2, like 2 |
multiple interactions |
ISO |
Quinolinic Acid results in increased activity of and affects the localization of NFE2L2 protein |
CTD |
PMID:30876764 |
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NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
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G |
Pparg |
peroxisome proliferator activated receptor gamma |
multiple interactions decreases expression |
ISO |
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA]; naringin inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA] |
CTD |
PMID:30130594 |
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NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
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G |
Ppif |
peptidylprolyl isomerase F (cyclophilin F) |
increases response to substance |
EXP |
PPIF results in increased susceptibility to Quinolinic Acid |
CTD |
PMID:21378209 |
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NCBI chr14:25,693,998...25,700,892
Ensembl chr14:25,694,578...25,700,892
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G |
Rgs2 |
regulator of G-protein signaling 2 |
decreases expression |
ISO |
Quinolinic Acid results in decreased expression of RGS2 mRNA; Quinolinic Acid results in decreased expression of RGS2 protein |
CTD |
PMID:12207953 |
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NCBI chr 1:143,875,076...143,879,887
Ensembl chr 1:143,875,076...143,879,899
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G |
Slc6a3 |
solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 |
decreases expression increases expression |
ISO |
Quinolinic Acid results in decreased expression of SLC6A3 protein Quinolinic Acid results in increased expression of SLC6A3 protein |
CTD |
PMID:12207953 |
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NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791
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G |
Sod1 |
superoxide dismutase 1, soluble |
decreases activity multiple interactions |
ISO |
Quinolinic Acid results in decreased activity of SOD1 protein Copper Sulfate inhibits the reaction [Quinolinic Acid results in decreased activity of SOD1 protein] |
CTD |
PMID:12899943 |
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NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
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G |
Sqstm1 |
sequestosome 1 |
multiple interactions |
ISO |
Quinolinic Acid promotes the reaction [SQSTM1 protein binds to KEAP1 protein] |
CTD |
PMID:30876764 |
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NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases expression |
ISO |
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of TNF protein]]; [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of TNF protein] Quinolinic Acid results in increased expression of TNF mRNA; Quinolinic Acid results in increased expression of TNF protein |
CTD |
PMID:20450929 PMID:30130594 |
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NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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