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G |
ALAS1 |
5'-aminolevulinate synthase 1 |
increases activity |
ISO |
pyridine results in increased activity of ALAS1 protein |
CTD |
PMID:10413312 |
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NCBI chr 3:52,198,083...52,214,327
Ensembl chr 3:52,198,086...52,214,327
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G |
CD86 |
CD86 molecule |
increases expression |
EXP |
pyridine results in increased expression of CD86 protein |
CTD |
PMID:19665512 |
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NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139
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G |
CYP1A1 |
cytochrome P450 family 1 subfamily A member 1 |
multiple interactions increases expression increases activity |
EXP ISO |
CYP2E1 protein promotes the reaction [pyridine results in increased expression of CYP1A1 mRNA]; Dimethyl Sulfoxide inhibits the reaction [CYP2E1 protein promotes the reaction [pyridine results in increased expression of CYP1A1 mRNA]] pyridine results in increased expression of CYP1A1 mRNA; pyridine results in increased expression of CYP1A1 protein pyridine results in increased activity of CYP1A1 protein |
CTD |
PMID:1857340 PMID:2241968 PMID:7493548 PMID:7511897 PMID:10413312 PMID:10463385 PMID:11849738 PMID:12147272 More...
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NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
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G |
CYP1A2 |
cytochrome P450 family 1 subfamily A member 2 |
increases expression increases activity |
ISO |
pyridine results in increased expression of CYP1A2 mRNA; pyridine results in increased expression of CYP1A2 protein pyridine results in increased activity of CYP1A2 protein |
CTD |
PMID:1857340 PMID:7493548 PMID:10413312 PMID:10463385 |
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NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
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G |
CYP2E1 |
cytochrome P450 family 2 subfamily E member 1 |
multiple interactions increases activity increases expression decreases activity |
EXP ISO |
CYP2E1 protein promotes the reaction [pyridine results in increased expression of CYP1A1 mRNA]; Dimethyl Sulfoxide inhibits the reaction [CYP2E1 protein promotes the reaction [pyridine results in increased expression of CYP1A1 mRNA]] pyridine results in increased activity of CYP2E1 protein pyridine results in increased expression of CYP2E1 mRNA; pyridine results in increased expression of CYP2E1 protein [pyridine co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 mRNA; [pyridine co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 protein; [pyridine co-treated with Methylcholanthrene] results in increased activity of CYP2E1 protein; [pyridine co-treated with Methylcholanthrene] results in increased expression of CYP2E1 protein; Cycloheximide inhibits the reaction [pyridine results in increased activity of CYP2E1 protein]; Cycloheximide inhibits the reaction [pyridine results in increased expression of CYP2E1 protein]; Ditiocarb inhibits the reaction [pyridine results in increased activity of CYP2E1 protein]; INS protein affects the reaction [pyridine results in increased expression of CYP2E1 protein]; pyridine promotes the reaction [ciprofibrate results in increased expression of CYP2E1 protein]; pyridine promotes the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] pyridine results in decreased activity of CYP2E1 protein |
CTD |
PMID:1379807 PMID:1610360 PMID:1968335 PMID:2241968 PMID:7587954 PMID:8074729 PMID:8246169 PMID:8734847 PMID:9618253 PMID:10215695 PMID:11181506 PMID:12147272 PMID:12464242 PMID:12919724 PMID:23211455 More...
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NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
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G |
CYP3A4 |
cytochrome P450 family 3 subfamily A member 4 |
increases activity increases expression multiple interactions |
ISO |
pyridine results in increased activity of CYP3A2 protein pyridine results in increased expression of CYP3A2 mRNA; pyridine results in increased expression of CYP3A2 protein cordycepin inhibits the reaction [pyridine results in increased expression of CYP3A2 mRNA]; Cycloheximide inhibits the reaction [pyridine results in increased expression of CYP3A2 mRNA]; Dactinomycin inhibits the reaction [pyridine results in increased expression of CYP3A2 mRNA] |
CTD |
PMID:11181506 |
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NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
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G |
FOS |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
pyridine promotes the reaction [Carbon Tetrachloride results in increased expression of FOS mRNA] |
CTD |
PMID:8825185 |
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NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
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G |
GRIN2B |
glutamate ionotropic receptor NMDA type subunit 2B |
multiple interactions |
ISO |
pyridine analog binds to and results in decreased activity of GRIN2B protein |
CTD |
PMID:17768047 |
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NCBI chr12:13,537,337...13,982,134
Ensembl chr12:13,437,942...13,982,002
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G |
HMOX1 |
heme oxygenase 1 |
increases activity increases expression |
ISO |
pyridine results in increased activity of HMOX1 protein pyridine results in increased expression of HMOX1 mRNA; pyridine results in increased expression of HMOX1 protein |
CTD |
PMID:10413312 |
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NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
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G |
HSF1 |
heat shock transcription factor 1 |
increases activity |
EXP |
pyridine results in increased activity of HSF1 protein |
CTD |
PMID:34170685 |
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NCBI chr 8:144,291,604...144,314,720
Ensembl chr 8:144,291,591...144,314,720
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G |
INS |
insulin |
multiple interactions |
ISO |
INS protein affects the reaction [pyridine results in increased expression of CYP2B1 mRNA]; INS protein affects the reaction [pyridine results in increased expression of CYP2B1 protein]; INS protein affects the reaction [pyridine results in increased expression of CYP2E1 protein] |
CTD |
PMID:10215695 |
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NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221
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G |
JUN |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
pyridine promotes the reaction [Carbon Tetrachloride results in increased expression of JUN mRNA] |
CTD |
PMID:8825185 |
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NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
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G |
KCNH2 |
potassium voltage-gated channel subfamily H member 2 |
affects binding |
EXP |
pyridine analog binds to KCNH2 protein |
CTD |
PMID:17768047 |
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NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321
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G |
TDO2 |
tryptophan 2,3-dioxygenase |
multiple interactions |
ISO |
Heme promotes the reaction [pyridine results in increased activity of TDO2 protein] |
CTD |
PMID:10413312 |
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NCBI chr 4:155,903,696...155,920,406
Ensembl chr 4:155,854,738...155,920,406
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G |
CASP3 |
caspase 3 |
multiple interactions |
EXP |
[Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased cleavage of CASP3 protein |
CTD |
PMID:17327230 |
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NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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G |
CASP9 |
caspase 9 |
multiple interactions |
EXP |
[Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased cleavage of CASP9 protein |
CTD |
PMID:17327230 |
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NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
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G |
CDKN1A |
cyclin dependent kinase inhibitor 1A |
multiple interactions |
EXP |
[Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased expression of CDKN1A protein |
CTD |
PMID:17327230 |
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NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
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G |
CYCS |
cytochrome c, somatic |
multiple interactions |
EXP |
[Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which affects the localization of CYCS protein |
CTD |
PMID:17327230 |
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NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
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G |
HRH1 |
histamine receptor H1 |
multiple interactions |
ISO |
2-(2-aminoethyl)pyridine binds to and results in increased activity of HRH1 protein; HRH1 protein promotes the reaction [2-(2-aminoethyl)pyridine results in increased expression of IL6 mRNA] |
CTD |
PMID:9657254 PMID:16143415 |
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NCBI chr 3:11,137,238...11,263,557
Ensembl chr 3:11,137,093...11,263,557
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G |
IL6 |
interleukin 6 |
increases expression multiple interactions |
ISO |
2-(2-aminoethyl)pyridine results in increased expression of IL6 mRNA HRH1 protein promotes the reaction [2-(2-aminoethyl)pyridine results in increased expression of IL6 mRNA] |
CTD |
PMID:9657254 |
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NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
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G |
SOD1 |
superoxide dismutase 1 |
multiple interactions |
EXP |
SOD1 protein results in decreased susceptibility to [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] |
CTD |
PMID:17327230 |
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NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
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G |
TP53 |
tumor protein p53 |
multiple interactions |
EXP |
[Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased expression of TP53 protein |
CTD |
PMID:17327230 |
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NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
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G |
GLUD1 |
glutamate dehydrogenase 1 |
decreases activity multiple interactions |
ISO |
dipicolinic acid results in decreased activity of GLUD1 protein dipicolinic acid inhibits the reaction [[GLUD1 protein co-treated with Ketoglutaric Acids co-treated with NADP co-treated with Aminooxyacetic Acid] affects the reaction [Carbon Tetrachloride affects the abundance of Ammonia]] |
CTD |
PMID:26639393 |
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NCBI chr10:87,050,202...87,094,843
Ensembl chr10:87,050,202...87,094,843
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G |
MAPT |
microtubule associated protein tau |
multiple interactions |
EXP |
dipicolinic acid promotes the reaction [MAPT protein binds to MAPT protein] |
CTD |
PMID:31678113 |
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NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334
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G |
ACMSD |
aminocarboxymuconate semialdehyde decarboxylase |
affects abundance |
ISO |
ACMSD protein affects the abundance of Quinolinic Acid |
CTD |
PMID:17896587 |
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NCBI chr 2:134,838,616...134,902,034
Ensembl chr 2:134,838,616...134,902,034
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G |
AHR |
aryl hydrocarbon receptor |
increases activity |
EXP |
Quinolinic Acid results in increased activity of AHR protein |
CTD |
PMID:28336214 |
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NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
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G |
BAX |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
ISO |
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA] |
CTD |
PMID:30130594 |
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NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
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G |
BCL2 |
BCL2 apoptosis regulator |
decreases expression multiple interactions |
ISO |
Quinolinic Acid results in decreased expression of BCL2 mRNA [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA]; naringin inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA] |
CTD |
PMID:30130594 |
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NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
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G |
BDNF |
brain derived neurotrophic factor |
increases expression |
ISO |
Quinolinic Acid results in increased expression of BDNF mRNA |
CTD |
PMID:15698628 |
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NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
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G |
CASP3 |
caspase 3 |
multiple interactions increases activity increases expression |
ISO |
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; Gallic Acid inhibits the reaction [Quinolinic Acid results in increased activity of CASP3 protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; wedelolactone inhibits the reaction [Quinolinic Acid results in increased activity of CASP3 protein] |
CTD |
PMID:29981346 PMID:30130594 |
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NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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G |
CAT |
catalase |
multiple interactions decreases activity decreases expression |
ISO |
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [pioglitazone inhibits the reaction [Quinolinic Acid results in decreased activity of CAT protein]]; nimesulide inhibits the reaction [Quinolinic Acid results in decreased expression of CAT protein]; pioglitazone inhibits the reaction [Quinolinic Acid results in decreased activity of CAT protein]; rofecoxib inhibits the reaction [Quinolinic Acid results in decreased expression of CAT protein] |
CTD |
PMID:20043943 PMID:20450929 |
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NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
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G |
CHAT |
choline O-acetyltransferase |
multiple interactions decreases activity |
ISO |
Dizocilpine Maleate inhibits the reaction [Quinolinic Acid results in decreased activity of CHAT protein] |
CTD |
PMID:2976130 |
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NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,667,942
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G |
CP |
ceruloplasmin |
multiple interactions |
ISO |
[Copper Sulfate co-treated with Quinolinic Acid] results in increased activity of CP protein |
CTD |
PMID:12899943 |
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NCBI chr 3:149,162,414...149,221,829
Ensembl chr 3:149,162,410...149,221,829
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G |
DPP3 |
dipeptidyl peptidase 3 |
multiple interactions |
ISO |
Quinolinic Acid promotes the reaction [DPP3 protein binds to KEAP1 protein] |
CTD |
PMID:30876764 |
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NCBI chr11:66,480,434...66,509,657
Ensembl chr11:66,480,013...66,509,657
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G |
DRD1 |
dopamine receptor D1 |
decreases expression |
ISO |
Quinolinic Acid results in decreased expression of DRD1 protein |
CTD |
PMID:12207953 |
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NCBI chr 5:175,440,036...175,444,182
Ensembl chr 5:175,440,036...175,444,182
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G |
DRD2 |
dopamine receptor D2 |
increases expression |
ISO |
Quinolinic Acid results in increased expression of DRD2 protein |
CTD |
PMID:12207953 |
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NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
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G |
EIF2AK2 |
eukaryotic translation initiation factor 2 alpha kinase 2 |
multiple interactions |
ISO |
GW 506033X inhibits the reaction [Quinolinic Acid results in increased expression of and results in increased cleavage of EIF2AK2 protein]; Quinolinic Acid results in increased expression of and results in increased cleavage of EIF2AK2 protein |
CTD |
PMID:24211709 |
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NCBI chr 2:37,099,210...37,156,980
Ensembl chr 2:37,099,210...37,157,522
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G |
EIF2S1 |
eukaryotic translation initiation factor 2 subunit alpha |
increases phosphorylation multiple interactions |
ISO |
Quinolinic Acid results in increased phosphorylation of EIF2S1 protein [Quinolinic Acid co-treated with GW 506033X] results in increased phosphorylation of EIF2S1 protein |
CTD |
PMID:24211709 |
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NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516
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G |
FGF1 |
fibroblast growth factor 1 |
decreases secretion |
ISO EXP |
Quinolinic Acid results in decreased secretion of FGF1 protein |
CTD |
PMID:16392031 |
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NCBI chr 5:142,592,178...142,698,070
Ensembl chr 5:142,592,178...142,698,070
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G |
FOS |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
Quinolinic Acid results in increased expression of FOS mRNA |
CTD |
PMID:15698628 |
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NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
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G |
G6PD |
glucose-6-phosphate dehydrogenase |
increases activity |
ISO |
Quinolinic Acid results in increased activity of G6PD protein |
CTD |
PMID:30876764 |
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NCBI chr X:154,531,390...154,547,569
Ensembl chr X:154,517,825...154,547,572
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G |
IL1B |
interleukin 1 beta |
increases expression multiple interactions |
ISO |
Quinolinic Acid results in increased expression of IL1B mRNA; Quinolinic Acid results in increased expression of IL1B protein [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]; Gallic Acid inhibits the reaction [Quinolinic Acid results in increased expression of IL1B protein]; GW 506033X inhibits the reaction [Quinolinic Acid results in increased expression of IL1B protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]; wedelolactone inhibits the reaction [Quinolinic Acid results in increased expression of IL1B protein] |
CTD |
PMID:24211709 PMID:29981346 PMID:30130594 |
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NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
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G |
IL6 |
interleukin 6 |
multiple interactions increases expression |
ISO |
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; Gallic Acid inhibits the reaction [Quinolinic Acid results in increased expression of IL6 protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; wedelolactone inhibits the reaction [Quinolinic Acid results in increased expression of IL6 protein] Quinolinic Acid results in increased expression of IL6 mRNA; Quinolinic Acid results in increased expression of IL6 protein |
CTD |
PMID:29981346 PMID:30130594 |
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NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
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G |
KEAP1 |
kelch like ECH associated protein 1 |
multiple interactions |
ISO |
Quinolinic Acid promotes the reaction [DPP3 protein binds to KEAP1 protein]; Quinolinic Acid promotes the reaction [SQSTM1 protein binds to KEAP1 protein]; Quinolinic Acid results in increased expression of and affects the localization of KEAP1 protein |
CTD |
PMID:30876764 |
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NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558
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G |
MAPT |
microtubule associated protein tau |
multiple interactions |
EXP |
Quinolinic Acid promotes the reaction [MAPT protein binds to MAPT protein] |
CTD |
PMID:31678113 |
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NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334
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G |
NFE2L2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
Quinolinic Acid results in increased activity of and affects the localization of NFE2L2 protein |
CTD |
PMID:30876764 |
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NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
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G |
PPARG |
peroxisome proliferator activated receptor gamma |
decreases expression multiple interactions |
ISO |
Quinolinic Acid results in decreased expression of PPARG mRNA [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA]; naringin inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA] |
CTD |
PMID:30130594 |
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NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
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G |
PPIF |
peptidylprolyl isomerase F |
increases response to substance |
ISO |
PPIF results in increased susceptibility to Quinolinic Acid |
CTD |
PMID:21378209 |
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NCBI chr10:79,347,469...79,355,334
Ensembl chr10:79,347,469...79,355,334
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G |
RGS2 |
regulator of G protein signaling 2 |
decreases expression |
ISO |
Quinolinic Acid results in decreased expression of RGS2 mRNA; Quinolinic Acid results in decreased expression of RGS2 protein |
CTD |
PMID:12207953 |
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NCBI chr 1:192,809,039...192,812,275
Ensembl chr 1:192,809,039...192,812,275
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G |
SLC6A3 |
solute carrier family 6 member 3 |
decreases expression increases expression |
ISO |
Quinolinic Acid results in decreased expression of SLC6A3 protein Quinolinic Acid results in increased expression of SLC6A3 protein |
CTD |
PMID:12207953 |
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NCBI chr 5:1,392,794...1,445,440
Ensembl chr 5:1,392,794...1,445,440
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G |
SOD1 |
superoxide dismutase 1 |
decreases activity multiple interactions |
ISO |
Quinolinic Acid results in decreased activity of SOD1 protein Copper Sulfate inhibits the reaction [Quinolinic Acid results in decreased activity of SOD1 protein] |
CTD |
PMID:12899943 |
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NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
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G |
SQSTM1 |
sequestosome 1 |
multiple interactions |
ISO |
Quinolinic Acid promotes the reaction [SQSTM1 protein binds to KEAP1 protein] |
CTD |
PMID:30876764 |
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NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
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G |
TNF |
tumor necrosis factor |
multiple interactions increases expression |
ISO |
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of TNF protein]]; [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of TNF protein] Quinolinic Acid results in increased expression of TNF mRNA; Quinolinic Acid results in increased expression of TNF protein |
CTD |
PMID:20450929 PMID:30130594 |
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NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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