|
G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
ISO |
cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA] |
CTD |
PMID:29250925 |
|
NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
|
|
G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
decreases expression |
ISO |
cucurbitacin B results in decreased expression of ADIPOQ mRNA |
CTD |
PMID:24316209 |
|
NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of BAX mRNA] |
CTD |
PMID:29250925 |
|
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased expression of BCL2 mRNA] |
CTD |
PMID:29250925 |
|
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
|
|
G |
Cat |
catalase |
multiple interactions |
ISO |
cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] |
CTD |
PMID:29250925 |
|
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
|
|
G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
cucurbitacin B results in decreased expression of CCND1 |
CTD |
PMID:24316209 |
|
NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
|
|
G |
Cd36 |
CD36 molecule |
decreases expression |
ISO |
cucurbitacin B results in decreased expression of CD36 mRNA |
CTD |
PMID:24316209 |
|
NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
|
|
G |
Cebpa |
CCAAT/enhancer binding protein alpha |
decreases expression multiple interactions |
ISO |
cucurbitacin B results in decreased expression of CEBPA mRNA STAT3 protein affects the reaction [cucurbitacin B results in decreased expression of CEBPA mRNA] |
CTD |
PMID:24316209 |
|
NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
|
|
G |
Cebpd |
CCAAT/enhancer binding protein delta |
decreases expression |
ISO |
cucurbitacin B results in decreased expression of CEBPD |
CTD |
PMID:24316209 |
|
NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146
|
|
G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
ISO |
cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA] |
CTD |
PMID:29250925 |
|
NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
|
|
G |
Fabp4 |
fatty acid binding protein 4 |
decreases expression |
ISO |
cucurbitacin B results in decreased expression of FABP4 mRNA |
CTD |
PMID:24316209 |
|
NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein] |
CTD |
PMID:29250925 |
|
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
|
|
G |
Klf5 |
Kruppel-like factor 5 |
increases expression |
ISO |
cucurbitacin B results in increased expression of KLF5 |
CTD |
PMID:24316209 |
|
NCBI chr15:83,703,796...83,722,921
Ensembl chr15:83,703,791...83,722,921
|
|
G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
ISO |
cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP2 mRNA] |
CTD |
PMID:29250925 |
|
NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
|
|
G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions decreases expression |
ISO |
STAT3 protein affects the reaction [cucurbitacin B results in decreased expression of PPARG mRNA] |
CTD |
PMID:24316209 |
|
NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
|
|
G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions affects response to substance |
ISO |
[WP1066 results in decreased activity of STAT3 protein] which results in decreased susceptibility to cucurbitacin B; cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein]; cucurbitacin B results in decreased phosphorylation of and results in decreased activity of STAT3 protein; STAT3 protein affects the reaction [cucurbitacin B results in decreased expression of CEBPA mRNA]; STAT3 protein affects the reaction [cucurbitacin B results in decreased expression of PPARG mRNA] STAT3 protein affects the susceptibility to cucurbitacin B |
CTD |
PMID:24316209 PMID:29250925 |
|
NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA] |
CTD |
PMID:29250925 |
|
NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein] |
CTD |
PMID:29250925 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
|
|
|
G |
Acta2 |
actin alpha 2, smooth muscle |
decreases expression multiple interactions |
EXP ISO |
cucurbitacin E results in decreased expression of ACTA2 mRNA; cucurbitacin E results in decreased expression of ACTA2 protein cucurbitacin E inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein] |
CTD |
PMID:27363783 |
|
NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions affects phosphorylation |
ISO |
Acetylcysteine inhibits the reaction [cucurbitacin E affects the phosphorylation of AKT1 protein] |
CTD |
PMID:27106530 |
|
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO EXP |
cucurbitacin E results in increased expression of BAX protein |
CTD |
PMID:27106530 PMID:27363783 |
|
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO EXP |
cucurbitacin E results in decreased expression of BCL2 protein |
CTD |
PMID:27106530 PMID:27363783 |
|
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
|
|
G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
ISO |
cucurbitacin E results in decreased expression of BCL2L1 protein |
CTD |
PMID:27106530 |
|
NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
|
|
G |
Becn1 |
beclin 1 |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [cucurbitacin E results in increased expression of and results in increased phosphorylation of BECN1 protein]; cucurbitacin E results in increased expression of and results in increased phosphorylation of BECN1 protein |
CTD |
PMID:27106530 |
|
NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
|
|
G |
Casp3 |
caspase 3 |
multiple interactions increases cleavage |
ISO EXP |
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [cucurbitacin E results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E results in increased cleavage of CASP3 protein] |
CTD |
PMID:27106530 PMID:27363783 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
|
|
G |
Casp7 |
caspase 7 |
multiple interactions increases cleavage |
ISO |
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [cucurbitacin E results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E results in increased cleavage of CASP7 protein] |
CTD |
PMID:27106530 |
|
NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
|
|
G |
Casp9 |
caspase 9 |
increases cleavage |
ISO |
cucurbitacin E results in increased cleavage of CASP9 protein |
CTD |
PMID:27106530 |
|
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
|
|
G |
Col1a1 |
collagen type I alpha 1 chain |
decreases expression |
EXP |
cucurbitacin E results in decreased expression of COL1A1 mRNA |
CTD |
PMID:27363783 |
|
NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
decreases phosphorylation |
EXP |
cucurbitacin E results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:27363783 |
|
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
decreases phosphorylation |
EXP |
cucurbitacin E results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:27363783 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
|
|
G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions decreases phosphorylation |
ISO EXP |
Acetylcysteine inhibits the reaction [cucurbitacin E results in decreased phosphorylation of MTOR protein] cucurbitacin E inhibits the reaction [Thioacetamide results in increased phosphorylation of MTOR protein] |
CTD |
PMID:27106530 PMID:27363783 |
|
NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
ISO EXP |
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [cucurbitacin E results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E results in increased cleavage of PARP1 protein] |
CTD |
PMID:27106530 PMID:27363783 |
|
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
|
|
G |
Pten |
phosphatase and tensin homolog |
multiple interactions |
ISO |
cucurbitacin E results in increased expression of and results in increased phosphorylation of PTEN protein |
CTD |
PMID:27106530 |
|
NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
|
|
G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
multiple interactions decreases phosphorylation |
ISO EXP |
cucurbitacin E inhibits the reaction [Thioacetamide results in increased phosphorylation of RPS6KB1 protein] cucurbitacin E results in decreased phosphorylation of RPS6KB1 protein |
CTD |
PMID:27363783 |
|
NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
|
|
G |
Sqstm1 |
sequestosome 1 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [cucurbitacin E results in increased expression of SQSTM1 protein] |
CTD |
PMID:27106530 |
|
NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
|
|
G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
multiple interactions decreases expression |
ISO EXP |
cucurbitacin E inhibits the reaction [Thioacetamide results in increased expression of TIMP1 protein] cucurbitacin E results in decreased expression of TIMP1 mRNA; cucurbitacin E results in decreased expression of TIMP1 protein |
CTD |
PMID:27363783 |
|
NCBI chr X:1,364,771...1,369,451
Ensembl chr X:1,364,786...1,369,384
|
|
G |
Ulk1 |
unc-51 like autophagy activating kinase 1 |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [cucurbitacin E results in decreased expression of and results in decreased phosphorylation of ULK1 protein]; cucurbitacin E results in decreased expression of and results in decreased phosphorylation of ULK1 protein |
CTD |
PMID:27106530 |
|
NCBI chr12:51,908,105...51,934,704
Ensembl chr12:51,908,448...51,934,702
|
|
|
G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
cucurbitacin I inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin] |
CTD |
PMID:16904803 |
|
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
|
|
G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions |
EXP |
cucurbitacin I inhibits the reaction [ADIPOQ protein results in increased expression of HMOX1 mRNA] |
CTD |
PMID:20052772 |
|
NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
|
|
G |
Casp3 |
caspase 3 |
increases cleavage |
ISO |
cucurbitacin I results in increased cleavage of CASP3 protein |
CTD |
PMID:24858077 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
|
|
G |
Casp7 |
caspase 7 |
increases cleavage |
ISO |
cucurbitacin I results in increased cleavage of CASP7 protein |
CTD |
PMID:24858077 |
|
NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
|
|
G |
Casp8 |
caspase 8 |
increases cleavage |
ISO |
cucurbitacin I results in increased cleavage of CASP8 protein |
CTD |
PMID:24858077 |
|
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
|
|
G |
Casp9 |
caspase 9 |
increases cleavage |
ISO |
cucurbitacin I results in increased cleavage of CASP9 protein |
CTD |
PMID:24858077 |
|
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
|
|
G |
Ccna2 |
cyclin A2 |
decreases expression |
ISO |
cucurbitacin I results in decreased expression of CCNA2 protein |
CTD |
PMID:24858077 |
|
NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
|
|
G |
Ccnb1 |
cyclin B1 |
decreases expression |
ISO |
cucurbitacin I results in decreased expression of CCNB1 protein |
CTD |
PMID:24858077 |
|
NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
|
|
G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
cucurbitacin I results in decreased expression of CCND1 |
CTD |
PMID:24316209 |
|
NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
|
|
G |
Cd36 |
CD36 molecule |
decreases expression |
ISO |
cucurbitacin I results in decreased expression of CD36 mRNA |
CTD |
PMID:24316209 |
|
NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
|
|
G |
Cdc25c |
cell division cycle 25C |
decreases expression |
ISO |
cucurbitacin I results in decreased expression of CDC25C protein |
CTD |
PMID:24858077 |
|
NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
|
|
G |
Cdk1 |
cyclin-dependent kinase 1 |
decreases expression |
ISO |
cucurbitacin I results in decreased expression of CDK1 protein |
CTD |
PMID:24858077 |
|
NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
|
|
G |
Cebpa |
CCAAT/enhancer binding protein alpha |
decreases expression |
ISO |
cucurbitacin I results in decreased expression of CEBPA mRNA |
CTD |
PMID:24316209 |
|
NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
|
|
G |
Fabp4 |
fatty acid binding protein 4 |
decreases expression |
ISO |
cucurbitacin I results in decreased expression of FABP4 mRNA |
CTD |
PMID:24316209 |
|
NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
|
|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP |
cucurbitacin I inhibits the reaction [ADIPOQ protein results in increased expression of HMOX1 mRNA] |
CTD |
PMID:20052772 |
|
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
|
|
G |
Jak2 |
Janus kinase 2 |
multiple interactions |
ISO |
cucurbitacin I inhibits the reaction [glycine-extended gastrin 17 results in increased phosphorylation of and results in increased activity of JAK2 protein] |
CTD |
PMID:19153190 |
|
NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
|
|
G |
Klf5 |
Kruppel-like factor 5 |
increases expression |
ISO |
cucurbitacin I results in increased expression of KLF5 |
CTD |
PMID:24316209 |
|
NCBI chr15:83,703,796...83,722,921
Ensembl chr15:83,703,791...83,722,921
|
|
G |
Nppa |
natriuretic peptide A |
increases expression |
EXP |
cucurbitacin I results in increased expression of NPPA mRNA |
CTD |
PMID:27836799 |
|
NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
|
|
G |
Nppb |
natriuretic peptide B |
increases expression |
EXP |
cucurbitacin I results in increased expression of NPPB mRNA |
CTD |
PMID:27836799 |
|
NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
cucurbitacin I results in increased cleavage of PARP1 protein |
CTD |
PMID:24858077 |
|
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
|
|
G |
Pparg |
peroxisome proliferator-activated receptor gamma |
decreases expression |
ISO |
cucurbitacin I results in decreased expression of PPARG mRNA |
CTD |
PMID:24316209 |
|
NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
|
|
G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions affects response to substance decreases activity |
ISO |
cucurbitacin I inhibits the reaction [glycine-extended gastrin 17 results in increased phosphorylation of and results in increased activity of STAT3 protein] [WP1066 results in decreased activity of STAT3 protein] which results in decreased susceptibility to cucurbitacin I STAT3 protein affects the susceptibility to cucurbitacin I cucurbitacin I results in decreased activity of STAT3 protein |
CTD |
PMID:19153190 PMID:24316209 |
|
NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
|
|
G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
cucurbitacin I inhibits the reaction [Arsenic results in increased expression of VEGFA protein] |
CTD |
PMID:25559853 |
|
NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
|
|