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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:aztreonam
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Accession:CHEBI:161680 term browser browse the term
Definition:A synthetic monocyclic beta-lactam antibiotic (monobactam), used primarily to treat infections caused by Gram-negative bacteria. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking.
Synonyms:exact_synonym: (2S,3S)-3-{(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[(2-carboxypropan-2-yloxy)imino]acetamido}-2-methyl-4-oxoazetidine-1-sulfonate
 related_synonym: (Z,)-2-((((2-Amino-4-thiazolyl)(((2S,3S,)-2-methyl-4-oxo-1-sulfo-3-azetidinyl)carbamoyl)methylene)amino)oxy)-2-methylpropionic acid;   AZT;   Azactam;   Formula=C13H17N5O8S2;   InChI=1S/C13H17N5O8S2/c1-5-7(10(20)18(5)28(23,24)25)16-9(19)8(6-4-27-12(14)15-6)17-26-13(2,3)11(21)22/h4-5,7H,1-3H3,(H2,14,15)(H,16,19)(H,21,22)(H,23,24,25)/b17-8-/t5-,7-/m0/s1;   InChIKey=WZPBZJONDBGPKJ-VEHQQRBSSA-N;   Primbactam;   SMILES=C[C@H]1[C@H](NC(=O)C(=N/OC(C)(C)C(O)=O)\\c2csc([NH3+])n2)C(=O)N1S([O-])(=O)=O;   aztreonamum
 alt_id: CHEBI:2960;   CHEBI:41008
 xref: Beilstein:3577211;   CAS:78110-38-0;   DrugBank:DB00355;   Drug_Central:279;   KEGG:C06840;   KEGG:D00240
 xref_mesh: MESH:D001398
 xref: PDBeChem:AZR;   PMID:1384868;   PMID:15123864;   PMID:24119095;   PMID:24176390;   PMID:24369293;   PMID:25049240;   PMID:25091537;   PMID:25295210;   PMID:28543395;   PMID:29017833;   Patent:NL8100571;   Reaxys:3577211;   Wikipedia:Aztreonam



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aztreonam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO Aztreonam results in increased expression of ABCC2 mRNA CTD PMID:24657338 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression ISO Aztreonam results in increased expression of ABCG5 mRNA CTD PMID:24657338 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression ISO Aztreonam results in increased expression of ABCG8 mRNA CTD PMID:24657338 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 decreases expression ISO Aztreonam results in decreased expression of NPC1L1 mRNA CTD PMID:24657338 NCBI chr14:81,071,448...81,091,113
Ensembl chr14:81,071,451...81,091,113
JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 increases expression ISO Aztreonam results in increased expression of NR5A2 mRNA CTD PMID:24657338 NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326
JBrowse link
G RT1-Ha RT1 class II, locus Ha affects expression ISO Aztreonam affects the expression of HLA-DPA1 mRNA CTD PMID:25811541 NCBI chr20:4,760,631...4,770,662 JBrowse link
G Slc10a1 solute carrier family 10 member 1 increases expression ISO Aztreonam results in increased expression of SLC10A1 mRNA CTD PMID:24657338 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc10a2 solute carrier family 10 member 2 decreases expression ISO Aztreonam results in decreased expression of SLC10A2 mRNA CTD PMID:24657338 NCBI chr16:84,386,528...84,409,475
Ensembl chr16:84,374,862...84,409,475
JBrowse link
G Slc51b solute carrier family 51 subunit beta decreases expression ISO Aztreonam results in decreased expression of SLC51B mRNA CTD PMID:24657338 NCBI chr 8:65,931,891...65,934,893
Ensembl chr 8:65,931,890...65,940,145
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        antimicrobial agent 17472
          antibacterial agent 13975
            antibacterial drug 3190
              aztreonam 9
                aztreonyl group + 0
                aztreonyl-L-lysine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        carboacyl group 17469
                                          univalent carboacyl group 17469
                                            carbamoyl group 17285
                                              carboxamide 17285
                                                lactam 8308
                                                  beta-lactam 796
                                                    beta-lactam antibiotic 781
                                                      monobactam 9
                                                        aztreonam 9
                                                          aztreonyl group + 0
                                                          aztreonyl-L-lysine + 0
paths to the root