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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:aztreonam
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Accession:CHEBI:161680 term browser browse the term
Definition:A synthetic monocyclic beta-lactam antibiotic (monobactam), used primarily to treat infections caused by Gram-negative bacteria. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking.
Synonyms:exact_synonym: (2S,3S)-3-{(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[(2-carboxypropan-2-yloxy)imino]acetamido}-2-methyl-4-oxoazetidine-1-sulfonate
 related_synonym: (Z,)-2-((((2-Amino-4-thiazolyl)(((2S,3S,)-2-methyl-4-oxo-1-sulfo-3-azetidinyl)carbamoyl)methylene)amino)oxy)-2-methylpropionic acid;   AZT;   Azactam;   Formula=C13H17N5O8S2;   InChI=1S/C13H17N5O8S2/c1-5-7(10(20)18(5)28(23,24)25)16-9(19)8(6-4-27-12(14)15-6)17-26-13(2,3)11(21)22/h4-5,7H,1-3H3,(H2,14,15)(H,16,19)(H,21,22)(H,23,24,25)/b17-8-/t5-,7-/m0/s1;   InChIKey=WZPBZJONDBGPKJ-VEHQQRBSSA-N;   Primbactam;   SMILES=C[C@H]1[C@H](NC(=O)C(=N/OC(C)(C)C(O)=O)\\c2csc([NH3+])n2)C(=O)N1S([O-])(=O)=O;   aztreonamum
 alt_id: CHEBI:2960;   CHEBI:41008
 xref: Beilstein:3577211;   CAS:78110-38-0;   DrugBank:DB00355;   Drug_Central:279;   KEGG:C06840;   KEGG:D00240
 xref_mesh: MESH:D001398
 xref: PDBeChem:AZR;   PMID:1384868;   PMID:15123864;   PMID:24119095;   PMID:24176390;   PMID:24369293;   PMID:25049240;   PMID:25091537;   PMID:25295210;   PMID:28543395;   PMID:29017833;   Patent:NL8100571;   Reaxys:3577211;   Wikipedia:Aztreonam


show annotations for term's descendants           Sort by:
aztreonam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO Aztreonam results in increased expression of ABCC2 mRNA CTD PMID:24657338 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression ISO Aztreonam results in increased expression of ABCG5 mRNA CTD PMID:24657338 NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:15,717,936...15,743,376 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression ISO Aztreonam results in increased expression of ABCG8 mRNA CTD PMID:24657338 NCBI chr 6:15,698,448...15,717,730
Ensembl chr 6:15,698,448...15,717,730 		JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 decreases expression ISO Aztreonam results in decreased expression of NPC1L1 mRNA CTD PMID:24657338 NCBI chr14:85,285,387...85,305,050
Ensembl chr14:85,285,390...85,305,050 		JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 increases expression ISO Aztreonam results in increased expression of NR5A2 mRNA CTD PMID:24657338 NCBI chr13:50,865,253...50,985,107
Ensembl chr13:50,867,920...50,984,938 		JBrowse link
G RT1-Ha RT1 class II, locus Ha affects expression ISO Aztreonam affects the expression of HLA-DPA1 mRNA CTD PMID:25811541 NCBI chr20:4,762,425...4,772,439
Ensembl chr20:4,763,033...4,772,141 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 increases expression ISO Aztreonam results in increased expression of SLC10A1 mRNA CTD PMID:24657338 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944 		JBrowse link
G Slc10a2 solute carrier family 10 member 2 decreases expression ISO Aztreonam results in decreased expression of SLC10A2 mRNA CTD PMID:24657338 NCBI chr16:91,088,089...91,111,025
Ensembl chr16:91,076,423...91,111,025 		JBrowse link
G Slc51b SLC51 subunit beta decreases expression ISO Aztreonam results in decreased expression of SLC51B mRNA CTD PMID:24657338 NCBI chr 8:74,827,047...74,835,109
Ensembl chr 8:74,827,047...74,835,109 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        antimicrobial agent 18578
          antibacterial agent 16665
            antibacterial drug 7535
              aztreonam 9
                aztreonyl group + 0
                aztreonyl-L-lysine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbon oxoacid 19155
                                    carboxylic acid 19152
                                      carboacyl group 18085
                                        univalent carboacyl group 18085
                                          carbamoyl group 17921
                                            carboxamide 17921
                                              lactam 8438
                                                beta-lactam 855
                                                  beta-lactam antibiotic 840
                                                    monobactam 9
                                                      aztreonam 9
                                                        aztreonyl group + 0
                                                        aztreonyl-L-lysine + 0
paths to the root