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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:aztreonam
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Accession:CHEBI:161680 term browser browse the term
Definition:A synthetic monocyclic beta-lactam antibiotic (monobactam), used primarily to treat infections caused by Gram-negative bacteria. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking.
Synonyms:exact_synonym: (2S,3S)-3-{(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[(2-carboxypropan-2-yloxy)imino]acetamido}-2-methyl-4-oxoazetidine-1-sulfonate
 related_synonym: (Z,)-2-((((2-Amino-4-thiazolyl)(((2S,3S,)-2-methyl-4-oxo-1-sulfo-3-azetidinyl)carbamoyl)methylene)amino)oxy)-2-methylpropionic acid;   AZT;   Azactam;   Formula=C13H17N5O8S2;   InChI=1S/C13H17N5O8S2/c1-5-7(10(20)18(5)28(23,24)25)16-9(19)8(6-4-27-12(14)15-6)17-26-13(2,3)11(21)22/h4-5,7H,1-3H3,(H2,14,15)(H,16,19)(H,21,22)(H,23,24,25)/b17-8-/t5-,7-/m0/s1;   InChIKey=WZPBZJONDBGPKJ-VEHQQRBSSA-N;   Primbactam;   SMILES=C[C@H]1[C@H](NC(=O)C(=N/OC(C)(C)C(O)=O)\\c2csc([NH3+])n2)C(=O)N1S([O-])(=O)=O;   aztreonamum
 alt_id: CHEBI:2960;   CHEBI:41008
 xref: Beilstein:3577211;   CAS:78110-38-0;   DrugBank:DB00355;   Drug_Central:279;   KEGG:C06840;   KEGG:D00240
 xref_mesh: MESH:D001398
 xref: PDBeChem:AZR;   PMID:1384868;   PMID:15123864;   PMID:24119095;   PMID:24176390;   PMID:24369293;   PMID:25049240;   PMID:25091537;   PMID:25295210;   PMID:28543395;   PMID:29017833;   Patent:NL8100571;   Reaxys:3577211;   Wikipedia:Aztreonam


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aztreonam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO Aztreonam results in increased expression of ABCC2 mRNA CTD PMID:24657338 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression ISO Aztreonam results in increased expression of ABCG5 mRNA CTD PMID:24657338 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression ISO Aztreonam results in increased expression of ABCG8 mRNA CTD PMID:24657338 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708
JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 decreases expression ISO Aztreonam results in decreased expression of NPC1L1 mRNA CTD PMID:24657338 NCBI chr14:86,345,946...86,560,694
Ensembl chr14:86,345,953...86,560,694
JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 increases expression ISO Aztreonam results in increased expression of NR5A2 mRNA CTD PMID:24657338 NCBI chr13:53,750,470...53,870,288
Ensembl chr13:53,750,473...53,870,428
JBrowse link
G RT1-Ha RT1 class II, locus Ha affects expression ISO Aztreonam affects the expression of HLA-DPA1 mRNA CTD PMID:25811541 NCBI chr20:3,875,478...3,885,140
Ensembl chr20:3,875,706...3,881,461
JBrowse link
G Slc10a1 solute carrier family 10 member 1 increases expression ISO Aztreonam results in increased expression of SLC10A1 mRNA CTD PMID:24657338 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Slc10a2 solute carrier family 10 member 2 decreases expression ISO Aztreonam results in decreased expression of SLC10A2 mRNA CTD PMID:24657338 NCBI chr16:90,324,420...90,350,254
Ensembl chr16:90,324,361...90,345,865
JBrowse link
G Slc51b solute carrier family 51 subunit beta decreases expression ISO Aztreonam results in decreased expression of SLC51B mRNA CTD PMID:24657338 NCBI chr 8:70,930,196...70,938,559
Ensembl chr 8:70,930,347...70,932,986
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      biological role 19825
        antimicrobial agent 17409
          antibacterial agent 13429
            antibacterial drug 3168
              aztreonam 9
                aztreonyl group + 0
                aztreonyl-L-lysine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic group 18569
                              organic divalent group 18560
                                organodiyl group 18560
                                  carbonyl group 18468
                                    carbonyl compound 18468
                                      carboxylic acid 18142
                                        carboacyl group 17404
                                          univalent carboacyl group 17404
                                            carbamoyl group 17189
                                              carboxamide 17189
                                                lactam 8049
                                                  beta-lactam 795
                                                    beta-lactam antibiotic 783
                                                      monobactam 9
                                                        aztreonam 9
                                                          aztreonyl group + 0
                                                          aztreonyl-L-lysine + 0
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