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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:benzoate
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Accession:CHEBI:16150 term browser browse the term
Definition:The simplest member of the class of benzoates that is the conjugate base of benzoic acid, comprising a benzoic acid core with a proton missing to give a charge of -1.
Synonyms:related_synonym: Benzenecarboxylate;   Benzeneformate;   Benzenemethanoate;   Formula=C7H5O2;   InChI=1S/C7H6O2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H,8,9)/p-1;   InChIKey=WPYMKLBDIGXBTP-UHFFFAOYSA-M;   Phenylcarboxylate;   Phenylformate;   SMILES=[O-]C(=O)c1ccccc1;   benzoate anion;   benzoic acid, ion(1-)
 alt_id: CHEBI:13879;   CHEBI:22717
 xref: Beilstein:1862486;   CAS:766-76-7;   Gmelin:2945;   HMDB:HMDB0001870;   KEGG:C00180;   MetaCyc:BENZOATE;   Reaxys:1862486;   UM-BBD_compID:c0121
 cyclic_relationship: is_conjugate_base_of CHEBI:30746



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3,4-dihydroxybenzoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epas1 endothelial PAS domain protein 1 increases expression
multiple interactions
ISO 3,4-dihydroxybenzoate results in increased expression of EPAS1 mRNA
[3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EPAS1 mRNA
CTD PMID:19679656 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions
affects localization
ISO
EXP
3,4-dihydroxybenzoate results in increased expression of HIF1A mRNA
[3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HIF1A mRNA
[3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine metabolite] affects the localization of HIF1A protein
3,4-dihydroxybenzoate affects the localization of HIF1A protein
CTD PMID:19679656 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO [3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HMOX1 mRNA; [3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HMOX1 protein
3,4-dihydroxybenzoate results in increased expression of HMOX1 mRNA; 3,4-dihydroxybenzoate results in increased expression of HMOX1 protein
CTD PMID:19679656 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions ISO 3,4-dihydroxybenzoate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC40A1 protein] CTD PMID:19679656 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO [3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SOD2 protein
3,4-dihydroxybenzoate results in increased expression of SOD2 protein
CTD PMID:19679656 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
sodium benzoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
increases activity
EXP Ascorbic Acid inhibits the reaction [Sodium Benzoate results in increased activity of ACHE protein] CTD PMID:35187746 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Sodium Benzoate inhibits the reaction [[DAO protein results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA] CTD PMID:19860415 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP Sodium Benzoate promotes the reaction [Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein] CTD PMID:17609678 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression
ISO
EXP
Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased activity of CASP3 protein]
Sodium Benzoate results in increased activity of CASP3 protein
Ascorbic Acid inhibits the reaction [Sodium Benzoate results in increased expression of CASP3 protein]
CTD PMID:11329530 PMID:32911041 PMID:35187746 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein] CTD PMID:12540492 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase decreases activity
multiple interactions
EXP Sodium Benzoate results in decreased activity of CAT protein
Ascorbic Acid inhibits the reaction [Sodium Benzoate results in decreased activity of CAT protein]
CTD PMID:32911041 PMID:35187746 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Sodium Benzoate inhibits the reaction [[DAO protein results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA] CTD PMID:19860415 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Dao D-amino-acid oxidase multiple interactions
decreases activity
ISO
EXP
Sodium Benzoate inhibits the reaction [[DAO protein results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]
Sodium Benzoate results in decreased activity of DAO protein
CTD PMID:19860415 PMID:20952482 NCBI chr12:42,592,342...42,613,046
Ensembl chr12:42,592,343...42,612,741
JBrowse link
G Esr1 estrogen receptor 1 decreases activity ISO Sodium Benzoate results in decreased activity of ESR1 protein CTD PMID:22562034 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression EXP Sodium Benzoate results in increased expression of FSHB protein CTD PMID:32911041 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP
Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNG protein]
[Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of IFNG mRNA
CTD PMID:26706697 PMID:32179172 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions EXP [Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of IL10 mRNA CTD PMID:32179172 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of IL1B mRNA CTD PMID:32179172 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO
EXP
Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
[Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of IL6 mRNA
Sodium Benzoate results in increased expression of IL6 protein
CTD PMID:26706697 PMID:32179172 PMID:32911041 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP Sodium Benzoate results in increased expression of LHB protein CTD PMID:32911041 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO Sodium Benzoate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA alternative form]; Sodium Benzoate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA] CTD PMID:9614211 NCBI chr16:52,717,775...52,803,602
Ensembl chr16:52,717,732...52,799,676
JBrowse link
G Otc ornithine transcarbamylase multiple interactions ISO Sodium Benzoate affects the reaction [OTC gene mutant form affects the abundance of Hydroxyindoleacetic Acid]; Sodium Benzoate affects the reaction [OTC gene mutant form affects the metabolism of Glycine]; Sodium Benzoate affects the reaction [OTC gene mutant form affects the metabolism of Serotonin]; Sodium Benzoate affects the reaction [OTC gene mutant form results in increased abundance of Ammonium Compounds] CTD PMID:3091026 PMID:3374991 NCBI chr  X:12,453,834...12,529,954
Ensembl chr  X:12,453,834...12,566,918
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression EXP Sodium Benzoate results in increased expression of TFAM protein CTD PMID:32911041 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
[Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of TNF mRNA; Ascorbic Acid inhibits the reaction [Sodium Benzoate results in increased expression of TNF protein]
CTD PMID:26706697 PMID:32179172 PMID:32911041 PMID:35187746 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO
EXP
Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 mRNA]
Sodium Benzoate results in increased expression of TP53 protein
CTD PMID:16357363 PMID:32911041 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ucp2 uncoupling protein 2 increases expression EXP Sodium Benzoate results in increased expression of UCP2 protein CTD PMID:32911041 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
JBrowse link
G Xdh xanthine dehydrogenase increases activity EXP Sodium Benzoate results in increased activity of XDH protein CTD PMID:32911041 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19803
    role 19779
      biological role 19806
        biochemical role 19514
          metabolite 19501
            eukaryotic metabolite 19320
              plant metabolite 17956
                benzoate 27
                  2,3-dihydroxybenzoate 0
                  2,3-dimethylbenzoate 0
                  2,4,6-trimethylbenzoate 0
                  2,4-dichlorobenzoate 0
                  2,4-dimethylbenzoate 0
                  2,5-dimethylbenzoate 0
                  2,6-dichlorobenzoate 0
                  2,6-dimethylbenzoate 0
                  2-diazoniobenzoate + 0
                  2-halobenzoate + 0
                  2-nitrobenzoate 0
                  3,4-dihydroxybenzoate 5
                  3,4-dimethylbenzoate 0
                  3,5-dibromo-4-hydroxybenzoate 0
                  3,5-dichloro-4-hydroxybenzoate 0
                  3,5-dimethylbenzoate 0
                  3-bromo-4-hydroxybenzoate 0
                  3-chlorobenzoate 0
                  3-diazoniobenzoate + 0
                  3-ethoxybenzoate 0
                  3-fluorobenzoate + 0
                  3-hydroxybenzoate + 0
                  4-aminobenzoate + 0
                  4-bromobenzoate + 0
                  4-chlorobenzoate + 0
                  4-diazoniobenzoate + 0
                  4-fluorobenzoate + 0
                  4-hydroxy-3-octaprenylbenzoate 0
                  4-hydroxybenzoate + 0
                  4-iodobenzoate + 0
                  4-methoxybenzoate + 0
                  4-nitrobenzoate 0
                  4-sulfonatobenzoate(2-) 0
                  cloperastine fendizoate 0
                  macrophomate 0
                  p-mercuribenzoate 0
                  sodium benzoate + 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19803
    subatomic particle 19801
      composite particle 19801
        hadron 19830
          baryon 19830
            nucleon 19830
              atomic nucleus 19830
                atom 19801
                  main group element atom 19780
                    p-block element atom 19780
                      carbon group element atom 19728
                        carbon atom 19725
                          organic molecular entity 19725
                            organic ion 9863
                              organic anion 3615
                                carboxylic acid anion 2475
                                  monocarboxylic acid anion 1591
                                    benzoates 1275
                                      benzoate 27
                                        2,3-dihydroxybenzoate 0
                                        2,3-dimethylbenzoate 0
                                        2,4,6-trimethylbenzoate 0
                                        2,4-dichlorobenzoate 0
                                        2,4-dimethylbenzoate 0
                                        2,5-dimethylbenzoate 0
                                        2,6-dichlorobenzoate 0
                                        2,6-dimethylbenzoate 0
                                        2-diazoniobenzoate + 0
                                        2-halobenzoate + 0
                                        2-nitrobenzoate 0
                                        3,4-dihydroxybenzoate 5
                                        3,4-dimethylbenzoate 0
                                        3,5-dibromo-4-hydroxybenzoate 0
                                        3,5-dichloro-4-hydroxybenzoate 0
                                        3,5-dimethylbenzoate 0
                                        3-bromo-4-hydroxybenzoate 0
                                        3-chlorobenzoate 0
                                        3-diazoniobenzoate + 0
                                        3-ethoxybenzoate 0
                                        3-fluorobenzoate + 0
                                        3-hydroxybenzoate + 0
                                        4-aminobenzoate + 0
                                        4-bromobenzoate + 0
                                        4-chlorobenzoate + 0
                                        4-diazoniobenzoate + 0
                                        4-fluorobenzoate + 0
                                        4-hydroxy-3-octaprenylbenzoate 0
                                        4-hydroxybenzoate + 0
                                        4-iodobenzoate + 0
                                        4-methoxybenzoate + 0
                                        4-nitrobenzoate 0
                                        4-sulfonatobenzoate(2-) 0
                                        cloperastine fendizoate 0
                                        macrophomate 0
                                        p-mercuribenzoate 0
                                        sodium benzoate + 22
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