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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:benzoate
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Accession:CHEBI:16150 term browser browse the term
Definition:The simplest member of the class of benzoates that is the conjugate base of benzoic acid, comprising a benzoic acid core with a proton missing to give a charge of -1.
Synonyms:related_synonym: Benzenecarboxylate;   Benzeneformate;   Benzenemethanoate;   Formula=C7H5O2;   InChI=1S/C7H6O2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H,8,9)/p-1;   InChIKey=WPYMKLBDIGXBTP-UHFFFAOYSA-M;   Phenylcarboxylate;   Phenylformate;   SMILES=[O-]C(=O)c1ccccc1;   benzoate anion;   benzoic acid, ion(1-)
 alt_id: CHEBI:13879;   CHEBI:22717
 xref: Beilstein:1862486;   CAS:766-76-7;   Gmelin:2945;   HMDB:HMDB0001870;   KEGG:C00180;   MetaCyc:BENZOATE;   Reaxys:1862486;   UM-BBD_compID:c0121
 cyclic_relationship: is_conjugate_base_of CHEBI:30746


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3,4-dihydroxybenzoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epas1 endothelial PAS domain protein 1 increases expression
multiple interactions
ISO 3,4-dihydroxybenzoate results in increased expression of EPAS1 mRNA
[3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EPAS1 mRNA
CTD PMID:19679656 NCBI chr 6:7,790,236...7,871,246
Ensembl chr 6:7,790,647...7,871,228
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
affects localization
multiple interactions
ISO
EXP
3,4-dihydroxybenzoate results in increased expression of HIF1A mRNA
3,4-dihydroxybenzoate affects the localization of HIF1A protein
[3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine metabolite] affects the localization of HIF1A protein
[3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HIF1A mRNA
CTD PMID:19679656 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO [3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HMOX1 mRNA; [3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HMOX1 protein
3,4-dihydroxybenzoate results in increased expression of HMOX1 mRNA; 3,4-dihydroxybenzoate results in increased expression of HMOX1 protein
CTD PMID:19679656 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions ISO 3,4-dihydroxybenzoate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC40A1 protein] CTD PMID:19679656 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO [3,4-dihydroxybenzoate co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SOD2 protein
3,4-dihydroxybenzoate results in increased expression of SOD2 protein
CTD PMID:19679656 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
sodium benzoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO Sodium Benzoate inhibits the reaction [[DAO protein results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA] CTD PMID:19860415 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP Sodium Benzoate promotes the reaction [Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein] CTD PMID:17609678 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO
EXP
Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased activity of CASP3 protein]
Sodium Benzoate results in increased activity of CASP3 protein
CTD PMID:11329530 PMID:32911041 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein] CTD PMID:12540492 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase decreases activity EXP Sodium Benzoate results in decreased activity of CAT protein CTD PMID:32911041 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Sodium Benzoate inhibits the reaction [[DAO protein results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA] CTD PMID:19860415 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Dao D-amino-acid oxidase multiple interactions
decreases activity
ISO
EXP
Sodium Benzoate inhibits the reaction [[DAO protein results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]
Sodium Benzoate results in decreased activity of DAO protein
CTD PMID:19860415 PMID:20952482 NCBI chr12:42,592,342...42,613,046
Ensembl chr12:42,592,343...42,612,741
JBrowse link
G Esr1 estrogen receptor 1 decreases activity ISO Sodium Benzoate results in decreased activity of ESR1 protein CTD PMID:22562034 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression EXP Sodium Benzoate results in increased expression of FSHB protein CTD PMID:32911041 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Ifng interferon gamma multiple interactions ISO Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNG protein] CTD PMID:26706697 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO
EXP
Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Sodium Benzoate results in increased expression of IL6 protein
CTD PMID:26706697 PMID:32911041 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP Sodium Benzoate results in increased expression of LHB protein CTD PMID:32911041 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO Sodium Benzoate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA alternative form]; Sodium Benzoate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA] CTD PMID:9614211 NCBI chr16:52,717,775...52,802,890
Ensembl chr16:52,717,732...52,799,676
JBrowse link
G Otc ornithine transcarbamylase multiple interactions ISO Sodium Benzoate affects the reaction [OTC gene mutant form affects the abundance of Hydroxyindoleacetic Acid]; Sodium Benzoate affects the reaction [OTC gene mutant form affects the metabolism of Glycine]; Sodium Benzoate affects the reaction [OTC gene mutant form affects the metabolism of Serotonin]; Sodium Benzoate affects the reaction [OTC gene mutant form results in increased abundance of Ammonium Compounds] CTD PMID:3091026 PMID:3374991 NCBI chr  X:12,453,834...12,529,954
Ensembl chr  X:12,453,834...12,566,918
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression EXP Sodium Benzoate results in increased expression of TFAM protein CTD PMID:32911041 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Sodium Benzoate results in increased expression of TNF protein
CTD PMID:26706697 PMID:32911041 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO
EXP
Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 mRNA]
Sodium Benzoate results in increased expression of TP53 protein
CTD PMID:16357363 PMID:32911041 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ucp2 uncoupling protein 2 increases expression EXP Sodium Benzoate results in increased expression of UCP2 protein CTD PMID:32911041 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
JBrowse link
G Xdh xanthine dehydrogenase increases activity EXP Sodium Benzoate results in increased activity of XDH protein CTD PMID:32911041 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        biochemical role 19381
          metabolite 19356
            eukaryotic metabolite 19044
              plant metabolite 17455
                benzoate 24
                  2,3-dihydroxybenzoate 0
                  2,3-dimethylbenzoate 0
                  2,4,6-trimethylbenzoate 0
                  2,4-dichlorobenzoate 0
                  2,4-dimethylbenzoate 0
                  2,5-dimethylbenzoate 0
                  2,6-dichlorobenzoate 0
                  2,6-dimethylbenzoate 0
                  2-diazoniobenzoate + 0
                  2-halobenzoate + 0
                  2-nitrobenzoate 0
                  3,4-dihydroxybenzoate 5
                  3,4-dimethylbenzoate 0
                  3,5-dibromo-4-hydroxybenzoate 0
                  3,5-dichloro-4-hydroxybenzoate 0
                  3,5-dimethylbenzoate 0
                  3-bromo-4-hydroxybenzoate 0
                  3-chlorobenzoate 0
                  3-diazoniobenzoate + 0
                  3-ethoxybenzoate 0
                  3-fluorobenzoate 0
                  3-hydroxybenzoate 0
                  4-aminobenzoate 0
                  4-chlorobenzoate 0
                  4-diazoniobenzoate + 0
                  4-fluorobenzoate 0
                  4-hydroxy-3-octaprenylbenzoate 0
                  4-hydroxybenzoate + 0
                  4-methoxybenzoate 0
                  4-nitrobenzoate 0
                  4-sulfonatobenzoate(2-) 0
                  cloperastine fendizoate 0
                  macrophomate 0
                  p-mercuribenzoate 0
                  sodium benzoate + 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic ion 9154
                              organic anion 3059
                                carboxylic acid anion 2401
                                  monocarboxylic acid anion 1501
                                    benzoates 1271
                                      benzoate 24
                                        2,3-dihydroxybenzoate 0
                                        2,3-dimethylbenzoate 0
                                        2,4,6-trimethylbenzoate 0
                                        2,4-dichlorobenzoate 0
                                        2,4-dimethylbenzoate 0
                                        2,5-dimethylbenzoate 0
                                        2,6-dichlorobenzoate 0
                                        2,6-dimethylbenzoate 0
                                        2-diazoniobenzoate + 0
                                        2-halobenzoate + 0
                                        2-nitrobenzoate 0
                                        3,4-dihydroxybenzoate 5
                                        3,4-dimethylbenzoate 0
                                        3,5-dibromo-4-hydroxybenzoate 0
                                        3,5-dichloro-4-hydroxybenzoate 0
                                        3,5-dimethylbenzoate 0
                                        3-bromo-4-hydroxybenzoate 0
                                        3-chlorobenzoate 0
                                        3-diazoniobenzoate + 0
                                        3-ethoxybenzoate 0
                                        3-fluorobenzoate 0
                                        3-hydroxybenzoate 0
                                        4-aminobenzoate 0
                                        4-chlorobenzoate 0
                                        4-diazoniobenzoate + 0
                                        4-fluorobenzoate 0
                                        4-hydroxy-3-octaprenylbenzoate 0
                                        4-hydroxybenzoate + 0
                                        4-methoxybenzoate 0
                                        4-nitrobenzoate 0
                                        4-sulfonatobenzoate(2-) 0
                                        cloperastine fendizoate 0
                                        macrophomate 0
                                        p-mercuribenzoate 0
                                        sodium benzoate + 19
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