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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chondroitin D-glucuronate
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Accession:CHEBI:16137 term browser browse the term
Definition:A mucopolysaccharide composed of repeating beta-D-glucopyranuronosyl-(1->3)-beta-D-N-acetylgalactosaminyl units.
Synonyms:related_synonym: Chondroitin;   Formula=(C14H21NO11)nH2O
 alt_id: CHEBI:13989;   CHEBI:13992;   CHEBI:23221;   CHEBI:3673
 xref: KEGG:C00401;   KEGG:G11334
 cyclic_relationship: is_conjugate_acid_of CHEBI:57652


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chondroitin sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arsb arylsulfatase B decreases abundance ISO ARSB protein results in decreased abundance of Chondroitin Sulfates CTD PMID:29794138 NCBI chr 2:23,385,154...23,543,028
Ensembl chr 2:23,385,183...23,544,963
JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions EXP [icatibant binds to and results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to Chondroitin Sulfates CTD PMID:21436127 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Bdnf brain-derived neurotrophic factor affects binding ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to BDNF protein CTD PMID:15385557 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G C3 complement C3 increases cleavage ISO Chondroitin Sulfates analog results in increased cleavage of C3 protein CTD PMID:18434646 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G C5 complement C5 increases cleavage ISO Chondroitin Sulfates analog results in increased cleavage of C5 protein CTD PMID:18434646 NCBI chr 3:14,049,993...14,113,931
NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of CASP3 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CASP3 mRNA] CTD PMID:17879260 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of CASP7 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CASP7 mRNA] CTD PMID:17879260 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Cat catalase multiple interactions EXP Chondroitin Sulfates inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] CTD PMID:12736501, PMID:15089041 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 affects binding ISO Chondroitin Sulfates binds to CCL2 protein CTD PMID:16385517 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ctsb cathepsin B multiple interactions ISO Chondroitin Sulfates inhibits the reaction [CTSB protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates inhibits the reaction [CTSB protein results in increased degradation of CXCL11 protein]; Chondroitin Sulfates inhibits the reaction [CTSB protein results in increased degradation of CXCL9 protein]; Chondroitin Sulfates promotes the reaction [CTSB protein results in increased cleavage of benzyloxycarbonyl-phenylalanylarginine-4-methylcoumaryl-7-amide] CTD PMID:25833952 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Ctsk cathepsin K multiple interactions ISO Chondroitin Sulfates inhibits the reaction [CTSK protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of benzyloxycarbonyl-phenylalanylarginine-4-methylcoumaryl-7-amide]; Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of CXCL2 protein]; Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of CXCL3 protein] CTD PMID:25833952 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
JBrowse link
G Ctsl cathepsin L multiple interactions ISO Chondroitin Sulfates inhibits the reaction [CTSL protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates inhibits the reaction [CTSL protein results in increased degradation of CXCL11 protein]; Chondroitin Sulfates promotes the reaction [CTSL protein results in increased cleavage of benzyloxycarbonyl-phenylalanylarginine-4-methylcoumaryl-7-amide]; Chondroitin Sulfates promotes the reaction [CTSL protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSL protein results in increased cleavage of CXCL2 protein] CTD PMID:25833952 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Ctss cathepsin S multiple interactions ISO Chondroitin Sulfates inhibits the reaction [CTSS protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates promotes the reaction [CTSS protein results in increased cleavage of benzyloxycarbonyl-phenylalanylarginine-4-methylcoumaryl-7-amide]; Chondroitin Sulfates promotes the reaction [CTSS protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSS protein results in increased cleavage of CXCL2 protein] CTD PMID:25833952 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions ISO Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSL protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSS protein results in increased cleavage of CXCL1 protein] CTD PMID:25833952 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Chondroitin Sulfates inhibits the reaction [CTSB protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates inhibits the reaction [CTSK protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates inhibits the reaction [CTSL protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates inhibits the reaction [CTSS protein results in increased degradation of CXCL10 protein] CTD PMID:25833952 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 multiple interactions ISO Chondroitin Sulfates inhibits the reaction [CTSB protein results in increased degradation of CXCL11 protein]; Chondroitin Sulfates inhibits the reaction [CTSL protein results in increased degradation of CXCL11 protein] CTD PMID:25833952 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of CXCL2 protein]; Chondroitin Sulfates promotes the reaction [CTSL protein results in increased cleavage of CXCL2 protein]; Chondroitin Sulfates promotes the reaction [CTSS protein results in increased cleavage of CXCL2 protein] CTD PMID:25833952 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSL protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSS protein results in increased cleavage of CXCL1 protein] CTD PMID:25833952 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 multiple interactions ISO Chondroitin Sulfates inhibits the reaction [CTSB protein results in increased degradation of CXCL9 protein] CTD PMID:25833952 NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712
JBrowse link
G F12 coagulation factor XII increases activity ISO Chondroitin Sulfates analog results in increased activity of F12 protein CTD PMID:18434646 NCBI chr17:9,736,577...9,744,420
Ensembl chr17:9,736,577...9,744,420
JBrowse link
G Fgf10 fibroblast growth factor 10 affects binding ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF10 protein; Chondroitin Sulfates analog binds to FGF10 protein CTD PMID:12221095, PMID:15385557 NCBI chr 2:51,673,480...51,747,533
Ensembl chr 2:51,672,722...51,750,369
JBrowse link
G Fgf16 fibroblast growth factor 16 affects binding EXP [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF16 protein; Chondroitin Sulfates analog binds to FGF16 protein CTD PMID:12221095, PMID:15385557 NCBI chr  X:76,786,728...76,796,311
Ensembl chr  X:76,786,466...76,797,069
JBrowse link
G Fgf18 fibroblast growth factor 18 affects binding ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF18 protein; Chondroitin Sulfates analog binds to FGF18 protein CTD PMID:12221095, PMID:15385557 NCBI chr10:18,047,109...18,082,290
Ensembl chr10:18,047,109...18,063,391
JBrowse link
G Fgf2 fibroblast growth factor 2 affects binding ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF2 protein; Chondroitin Sulfates analog binds to FGF2 protein CTD PMID:12221095, PMID:15385557 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgf23 fibroblast growth factor 23 increases activity ISO Chondroitin Sulfates analog results in increased activity of FGF23 protein CTD PMID:16081635 NCBI chr 4:159,622,404...159,630,082
Ensembl chr 4:159,622,404...159,630,082
JBrowse link
G Gdnf glial cell derived neurotrophic factor affects binding ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to GDNF protein CTD PMID:15385557 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Hbegf heparin-binding EGF-like growth factor affects binding ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to HBEGF protein; Chondroitin Sulfates analog binds to HBEGF protein CTD PMID:12221095, PMID:15385557 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of NOS2 protein; [Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of PTGES protein; [Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of PTGS2 protein; [Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in increased expression of TIMP3 mRNA; [Glucosamine co-treated with Chondroitin Sulfates] inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; [Glucosamine co-treated with Chondroitin Sulfates] inhibits the reaction [IL1B protein results in increased secretion of Nitrites] CTD PMID:17605605 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Itih1 inter-alpha trypsin inhibitor, heavy chain 1 multiple interactions ISO TNFAIP6 protein promotes the reaction [ITIH1 protein binds to Chondroitin Sulfates] CTD PMID:25561734 NCBI chr16:7,012,376...7,026,542
Ensembl chr16:7,012,354...7,026,540
JBrowse link
G Klkb1 kallikrein B1 increases activity ISO Chondroitin Sulfates analog results in increased activity of KLKB1 protein CTD PMID:18434646 NCBI chr16:50,151,127...50,175,407
Ensembl chr16:50,152,008...50,175,458
JBrowse link
G Mdk midkine affects binding ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to MDK protein; Chondroitin Sulfates analog binds to MDK protein CTD PMID:12221095, PMID:15385557 NCBI chr 3:80,841,003...80,843,895
Ensembl chr 3:80,841,005...80,842,916
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO [Glucosamine co-treated with Chondroitin Sulfates] results in decreased expression of MMP3 mRNA; [Glucosamine co-treated with Chondroitin Sulfates] results in decreased secretion of MMP3 protein CTD PMID:20110869 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP [Chondroitin Sulfates co-treated with Hyaluronic Acid] inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein] CTD PMID:14697411 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of NFKB1 protein] CTD PMID:17879260 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in decreased expression of NFKBIA protein] CTD PMID:17879260 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of NOS2 protein CTD PMID:17605605 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein]; Genistein inhibits the reaction [Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein]] CTD PMID:16945567 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions ISO Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein]; Genistein inhibits the reaction [Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein]] CTD PMID:16945567 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Ptges prostaglandin E synthase multiple interactions ISO [Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of PTGES protein CTD PMID:17605605 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of PTGS2 protein CTD PMID:17605605 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptn pleiotrophin affects binding ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to PTN protein; Chondroitin Sulfates analog binds to PTN protein CTD PMID:12221095, PMID:15385557 NCBI chr 4:64,239,156...64,330,996
Ensembl chr 4:64,239,158...64,330,996
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 affects binding ISO PTPN11 protein binds to Chondroitin Sulfates CTD PMID:29794138 NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of RELA protein] CTD PMID:17879260 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 multiple interactions ISO [Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in increased expression of TIMP3 mRNA CTD PMID:17605605 NCBI chr 7:23,543,125...23,594,170
Ensembl chr 7:23,544,215...23,594,133
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
[Chondroitin Sulfates co-treated with Hyaluronic Acid] inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
[Glucosamine co-treated with Chondroitin Sulfates] results in decreased expression of TNF
CTD PMID:14697411, PMID:20110869 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 multiple interactions ISO TNFAIP6 protein promotes the reaction [ITIH1 protein binds to Chondroitin Sulfates] CTD PMID:25561734 NCBI chr 3:37,545,238...37,564,704
Ensembl chr 3:37,545,238...37,564,699
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions
increases expression
ISO [Chondroitin Sulfates co-treated with Cholecalciferol] results in increased expression of TNFRSF11B mRNA; [Chondroitin Sulfates co-treated with Cholecalciferol] results in increased expression of TNFRSF11B protein; [Chondroitin Sulfates co-treated with Glucosamine co-treated with Cholecalciferol] results in increased expression of TNFRSF11B mRNA; [Chondroitin Sulfates co-treated with Glucosamine co-treated with Cholecalciferol] results in increased expression of TNFRSF11B protein; [Chondroitin Sulfates co-treated with Glucosamine] results in increased expression of TNFRSF11B mRNA; [Chondroitin Sulfates co-treated with Glucosamine] results in increased expression of TNFRSF11B protein
Chondroitin Sulfates results in increased expression of TNFRSF11B protein
CTD PMID:17996099 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
decreases expression
ISO [Chondroitin Sulfates co-treated with Glucosamine] inhibits the reaction [Cholecalciferol results in increased expression of TNFSF11 mRNA]; Chondroitin Sulfates inhibits the reaction [Cholecalciferol results in increased expression of TNFSF11 mRNA]; Chondroitin Sulfates inhibits the reaction [Glucosamine results in increased expression of TNFSF11 mRNA]
Chondroitin Sulfates results in decreased expression of TNFSF11 mRNA
CTD PMID:17996099 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Vegfa vascular endothelial growth factor A affects binding ISO [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to VEGFA protein CTD PMID:15385557 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            eukaryotic metabolite 18906
              animal metabolite 18712
                mammalian metabolite 18711
                  mouse metabolite 18388
                    chondroitin D-glucuronate 49
                      chondroitin sulfate + 49
                      chondroitin sulfate E 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            heteroorganic entity 19147
                              organochalcogen compound 18855
                                organooxygen compound 18777
                                  carbohydrates and carbohydrate derivatives 12178
                                    carbohydrate 12178
                                      polysaccharide 3031
                                        polysaccharide derivative 3013
                                          aminoglycan 390
                                            glycosaminoglycan 365
                                              mucopolysaccharide 339
                                                chondroitin D-glucuronate 49
                                                  chondroitin sulfate + 49
                                                  chondroitin sulfate E 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.