|
G
|
Arsb
|
arylsulfatase B
|
decreases abundance
|
ISO
|
ARSB protein results in decreased abundance of Chondroitin Sulfates
|
CTD |
PMID:29794138 |
|
NCBI chr 2:26,736,395...26,895,682
Ensembl chr 2:26,736,957...26,897,611
|
|
G
|
Bdkrb2
|
bradykinin receptor B2
|
multiple interactions
|
EXP
|
[icatibant binds to and results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to Chondroitin Sulfates
|
CTD |
PMID:21436127 |
|
NCBI chr 6:130,237,055...130,267,205
Ensembl chr 6:130,237,255...130,267,209
|
|
G
|
Bdnf
|
brain-derived neurotrophic factor
|
affects binding
|
ISO
|
[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to BDNF protein
|
CTD |
PMID:15385557 |
|
NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
|
|
G
|
C3
|
complement C3
|
increases cleavage
|
ISO
|
Chondroitin Sulfates analog results in increased cleavage of C3 protein
|
CTD |
PMID:18434646 |
|
NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339
|
|
G
|
C5
|
complement C5
|
increases cleavage
|
ISO
|
Chondroitin Sulfates analog results in increased cleavage of C5 protein
|
CTD |
PMID:18434646 |
|
NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:38,668,174...38,759,468
|
|
G
|
Casp3
|
caspase 3
|
multiple interactions
|
ISO
|
[Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of CASP3 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CASP3 mRNA]
|
CTD |
PMID:17879260 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
G
|
Casp7
|
caspase 7
|
multiple interactions
|
ISO
|
[Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of CASP7 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CASP7 mRNA]
|
CTD |
PMID:17879260 |
|
NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512
|
|
G
|
Cat
|
catalase
|
multiple interactions
|
EXP
|
Chondroitin Sulfates inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]
|
CTD |
PMID:12736501 PMID:15089041 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
|
|
G
|
Ccl2
|
C-C motif chemokine ligand 2
|
affects binding
|
ISO
|
Chondroitin Sulfates binds to CCL2 protein
|
CTD |
PMID:16385517 |
|
NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
|
|
G
|
Ctsb
|
cathepsin B
|
multiple interactions
|
ISO
|
Chondroitin Sulfates inhibits the reaction [CTSB protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates inhibits the reaction [CTSB protein results in increased degradation of CXCL11 protein]; Chondroitin Sulfates inhibits the reaction [CTSB protein results in increased degradation of CXCL9 protein]; Chondroitin Sulfates promotes the reaction [CTSB protein results in increased cleavage of benzyloxycarbonyl-phenylalanylarginine-4-methylcoumaryl-7-amide]
|
CTD |
PMID:25833952 |
|
NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478
|
|
G
|
Ctsk
|
cathepsin K
|
multiple interactions
|
ISO
|
Chondroitin Sulfates inhibits the reaction [CTSK protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of benzyloxycarbonyl-phenylalanylarginine-4-methylcoumaryl-7-amide]; Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of CXCL2 protein]; Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of CXCL3 protein]
|
CTD |
PMID:25833952 |
|
NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:185,747,165...185,765,582
|
|
G
|
Ctsl
|
cathepsin L
|
multiple interactions
|
ISO
|
Chondroitin Sulfates inhibits the reaction [CTSL protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates inhibits the reaction [CTSL protein results in increased degradation of CXCL11 protein]; Chondroitin Sulfates promotes the reaction [CTSL protein results in increased cleavage of benzyloxycarbonyl-phenylalanylarginine-4-methylcoumaryl-7-amide]; Chondroitin Sulfates promotes the reaction [CTSL protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSL protein results in increased cleavage of CXCL2 protein]
|
CTD |
PMID:25833952 |
|
NCBI chr17:770,104...776,266
Ensembl chr17:770,093...777,113
|
|
G
|
Ctss
|
cathepsin S
|
multiple interactions
|
ISO
|
Chondroitin Sulfates inhibits the reaction [CTSS protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates promotes the reaction [CTSS protein results in increased cleavage of benzyloxycarbonyl-phenylalanylarginine-4-methylcoumaryl-7-amide]; Chondroitin Sulfates promotes the reaction [CTSS protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSS protein results in increased cleavage of CXCL2 protein]
|
CTD |
PMID:25833952 |
|
NCBI chr 2:185,775,316...185,803,440
Ensembl chr 2:185,775,296...185,803,440
|
|
G
|
Cxcl1
|
C-X-C motif chemokine ligand 1
|
multiple interactions
|
ISO
|
Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSL protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSS protein results in increased cleavage of CXCL1 protein]
|
CTD |
PMID:25833952 |
|
NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811
|
|
G
|
Cxcl10
|
C-X-C motif chemokine ligand 10
|
multiple interactions
|
ISO
|
Chondroitin Sulfates inhibits the reaction [CTSB protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates inhibits the reaction [CTSK protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates inhibits the reaction [CTSL protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates inhibits the reaction [CTSS protein results in increased degradation of CXCL10 protein]
|
CTD |
PMID:25833952 |
|
NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261
|
|
G
|
Cxcl11
|
C-X-C motif chemokine ligand 11
|
multiple interactions
|
ISO
|
Chondroitin Sulfates inhibits the reaction [CTSB protein results in increased degradation of CXCL11 protein]; Chondroitin Sulfates inhibits the reaction [CTSL protein results in increased degradation of CXCL11 protein]
|
CTD |
PMID:25833952 |
|
NCBI chr14:15,973,728...15,976,503
Ensembl chr14:15,973,720...15,976,567
|
|
G
|
Cxcl2
|
C-X-C motif chemokine ligand 2
|
multiple interactions
|
ISO
|
Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of CXCL2 protein]; Chondroitin Sulfates promotes the reaction [CTSL protein results in increased cleavage of CXCL2 protein]; Chondroitin Sulfates promotes the reaction [CTSS protein results in increased cleavage of CXCL2 protein]
|
CTD |
PMID:25833952 |
|
NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255
|
|
G
|
Cxcl3
|
C-X-C motif chemokine ligand 3
|
multiple interactions
|
ISO
|
Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSL protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSS protein results in increased cleavage of CXCL1 protein]
|
CTD |
PMID:25833952 |
|
NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624
|
|
G
|
Cxcl9
|
C-X-C motif chemokine ligand 9
|
multiple interactions
|
ISO
|
Chondroitin Sulfates inhibits the reaction [CTSB protein results in increased degradation of CXCL9 protein]
|
CTD |
PMID:25833952 |
|
NCBI chr14:16,007,166...16,012,077
Ensembl chr14:16,007,204...16,014,299
|
|
G
|
F12
|
coagulation factor XII
|
increases activity
|
ISO
|
Chondroitin Sulfates analog results in increased activity of F12 protein
|
CTD |
PMID:18434646 |
|
NCBI chr17:9,212,819...9,220,664
Ensembl chr17:9,212,819...9,220,664
|
|
G
|
Fgf10
|
fibroblast growth factor 10
|
affects binding
|
ISO
|
[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF10 protein; Chondroitin Sulfates analog binds to FGF10 protein
|
CTD |
PMID:12221095 PMID:15385557 |
|
NCBI chr 2:52,533,939...52,610,980
Ensembl chr 2:52,533,939...52,610,980
|
|
G
|
Fgf16
|
fibroblast growth factor 16
|
affects binding
|
EXP
|
[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF16 protein; Chondroitin Sulfates analog binds to FGF16 protein
|
CTD |
PMID:12221095 PMID:15385557 |
|
NCBI chr X:74,882,863...74,893,598
Ensembl chr X:74,882,995...74,944,246
|
|
G
|
Fgf18
|
fibroblast growth factor 18
|
affects binding
|
ISO
|
[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF18 protein; Chondroitin Sulfates analog binds to FGF18 protein
|
CTD |
PMID:12221095 PMID:15385557 |
|
NCBI chr10:18,210,240...18,241,929
Ensembl chr10:18,210,512...18,240,933
|
|
G
|
Fgf2
|
fibroblast growth factor 2
|
affects binding
|
ISO
|
[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF2 protein; Chondroitin Sulfates analog binds to FGF2 protein
|
CTD |
PMID:12221095 PMID:15385557 |
|
NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493
|
|
G
|
Fgf23
|
fibroblast growth factor 23
|
increases activity
|
ISO
|
Chondroitin Sulfates analog results in increased activity of FGF23 protein
|
CTD |
PMID:16081635 |
|
NCBI chr 4:161,600,439...161,609,991
Ensembl chr 4:161,600,383...161,609,991
|
|
G
|
Gdnf
|
glial cell derived neurotrophic factor
|
affects binding
|
ISO
|
[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to GDNF protein
|
CTD |
PMID:15385557 |
|
NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:58,621,327...58,647,240
|
|
G
|
Hbegf
|
heparin-binding EGF-like growth factor
|
affects binding
|
ISO
|
[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to HBEGF protein; Chondroitin Sulfates analog binds to HBEGF protein
|
CTD |
PMID:12221095 PMID:15385557 |
|
NCBI chr18:28,380,337...28,390,220
Ensembl chr18:28,380,337...28,390,220
|
|
G
|
Il1b
|
interleukin 1 beta
|
multiple interactions
|
ISO
|
[Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of NOS2 protein; [Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of PTGES protein; [Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of PTGS2 protein; [Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in increased expression of TIMP3 mRNA; [Glucosamine co-treated with Chondroitin Sulfates] inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; [Glucosamine co-treated with Chondroitin Sulfates] inhibits the reaction [IL1B protein results in increased secretion of Nitrites]
|
CTD |
PMID:17605605 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
|
|
G
|
Itih1
|
inter-alpha trypsin inhibitor, heavy chain 1
|
multiple interactions
|
ISO
|
TNFAIP6 protein promotes the reaction [ITIH1 protein binds to Chondroitin Sulfates]
|
CTD |
PMID:25561734 |
|
NCBI chr16:6,128,696...6,142,813
Ensembl chr16:6,128,698...6,142,853
|
|
G
|
Klkb1
|
kallikrein B1
|
increases activity
|
ISO
|
Chondroitin Sulfates analog results in increased activity of KLKB1 protein
|
CTD |
PMID:18434646 |
|
NCBI chr16:53,690,180...53,714,570
Ensembl chr16:53,691,220...53,716,339
|
|
G
|
Mdk
|
midkine
|
affects binding
|
ISO
|
[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to MDK protein; Chondroitin Sulfates analog binds to MDK protein
|
CTD |
PMID:12221095 PMID:15385557 |
|
NCBI chr 3:98,356,789...98,358,960
Ensembl chr 3:98,356,789...98,358,743
|
|
G
|
Mmp3
|
matrix metallopeptidase 3
|
multiple interactions
|
ISO
|
[Glucosamine co-treated with Chondroitin Sulfates] results in decreased expression of MMP3 mRNA; [Glucosamine co-treated with Chondroitin Sulfates] results in decreased secretion of MMP3 protein
|
CTD |
PMID:20110869 |
|
NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826
|
|
G
|
Mpo
|
myeloperoxidase
|
multiple interactions
|
EXP
|
[Chondroitin Sulfates co-treated with Hyaluronic Acid] inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]
|
CTD |
PMID:14697411 |
|
NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
|
|
G
|
Nfkb1
|
nuclear factor kappa B subunit 1
|
multiple interactions
|
ISO
|
[Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of NFKB1 protein]
|
CTD |
PMID:17879260 |
|
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088
|
|
G
|
Nfkbia
|
NFKB inhibitor alpha
|
multiple interactions
|
ISO
|
[Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in decreased expression of NFKBIA protein]
|
CTD |
PMID:17879260 |
|
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
|
|
G
|
Nos2
|
nitric oxide synthase 2
|
multiple interactions
|
ISO
|
[Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of NOS2 protein
|
CTD |
PMID:17605605 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
|
|
G
|
Pdgfb
|
platelet derived growth factor subunit B
|
multiple interactions
|
ISO
|
Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein]; Genistein inhibits the reaction [Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein]]
|
CTD |
PMID:16945567 |
|
NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:113,420,710...113,438,343
|
|
G
|
Pdgfrb
|
platelet derived growth factor receptor beta
|
multiple interactions
|
ISO
|
Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein]; Genistein inhibits the reaction [Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein]]
|
CTD |
PMID:16945567 |
|
NCBI chr18:56,770,348...56,809,228
Ensembl chr18:56,770,348...56,809,233
|
|
G
|
Ptges
|
prostaglandin E synthase
|
multiple interactions
|
ISO
|
[Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of PTGES protein
|
CTD |
PMID:17605605 |
|
NCBI chr 3:34,575,643...34,586,987
Ensembl chr 3:34,575,639...34,586,995
|
|
G
|
Ptgs2
|
prostaglandin-endoperoxide synthase 2
|
multiple interactions
|
ISO
|
[Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of PTGS2 protein
|
CTD |
PMID:17605605 |
|
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
|
|
G
|
Ptn
|
pleiotrophin
|
affects binding
|
ISO
|
[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to PTN protein; Chondroitin Sulfates analog binds to PTN protein
|
CTD |
PMID:12221095 PMID:15385557 |
|
NCBI chr 4:66,260,764...66,342,614
Ensembl chr 4:66,260,764...66,342,482
|
|
G
|
Ptpn11
|
protein tyrosine phosphatase, non-receptor type 11
|
affects binding
|
ISO
|
PTPN11 protein binds to Chondroitin Sulfates
|
CTD |
PMID:29794138 |
|
NCBI chr12:41,026,079...41,085,577
Ensembl chr12:41,043,785...41,085,577
|
|
G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
multiple interactions
|
ISO
|
[Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of RELA protein]
|
CTD |
PMID:17879260 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
|
|
G
|
Timp3
|
TIMP metallopeptidase inhibitor 3
|
multiple interactions
|
ISO
|
[Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in increased expression of TIMP3 mRNA
|
CTD |
PMID:17605605 |
|
NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:19,409,631...19,459,547
|
|
G
|
Tnf
|
tumor necrosis factor
|
multiple interactions
|
EXP ISO
|
[Chondroitin Sulfates co-treated with Hyaluronic Acid] inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein] [Glucosamine co-treated with Chondroitin Sulfates] results in decreased expression of TNF
|
CTD |
PMID:14697411 PMID:20110869 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
|
|
G
|
Tnfaip6
|
TNF alpha induced protein 6
|
multiple interactions
|
ISO
|
TNFAIP6 protein promotes the reaction [ITIH1 protein binds to Chondroitin Sulfates]
|
CTD |
PMID:25561734 |
|
NCBI chr 3:56,911,398...56,930,797
Ensembl chr 3:56,911,252...56,930,796
|
|
G
|
Tnfrsf11b
|
TNF receptor superfamily member 11B
|
multiple interactions increases expression
|
ISO
|
[Chondroitin Sulfates co-treated with Cholecalciferol] results in increased expression of TNFRSF11B mRNA; [Chondroitin Sulfates co-treated with Cholecalciferol] results in increased expression of TNFRSF11B protein; [Chondroitin Sulfates co-treated with Glucosamine co-treated with Cholecalciferol] results in increased expression of TNFRSF11B mRNA; [Chondroitin Sulfates co-treated with Glucosamine co-treated with Cholecalciferol] results in increased expression of TNFRSF11B protein; [Chondroitin Sulfates co-treated with Glucosamine] results in increased expression of TNFRSF11B mRNA; [Chondroitin Sulfates co-treated with Glucosamine] results in increased expression of TNFRSF11B protein Chondroitin Sulfates results in increased expression of TNFRSF11B protein
|
CTD |
PMID:17996099 |
|
NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075
|
|
G
|
Tnfsf11
|
TNF superfamily member 11
|
multiple interactions decreases expression
|
ISO
|
[Chondroitin Sulfates co-treated with Glucosamine] inhibits the reaction [Cholecalciferol results in increased expression of TNFSF11 mRNA]; Chondroitin Sulfates inhibits the reaction [Cholecalciferol results in increased expression of TNFSF11 mRNA]; Chondroitin Sulfates inhibits the reaction [Glucosamine results in increased expression of TNFSF11 mRNA] Chondroitin Sulfates results in decreased expression of TNFSF11 mRNA
|
CTD |
PMID:17996099 |
|
NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479
|
|
G
|
Vegfa
|
vascular endothelial growth factor A
|
affects binding
|
ISO
|
[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to VEGFA protein
|
CTD |
PMID:15385557 |
|
NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
|
|