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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:palmatine
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Accession:CHEBI:16096 term browser browse the term
Definition:A berberine alkaloid that has formula C21H22NO4.
Synonyms:exact_synonym: 2,3,9,10-tetramethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium
 related_synonym: 5,6-Dihydro-2,3,9,10-tetramethoxydibenzo[a,g]quinolizinium;   7,8,13,13a-tetrahydro-2,3,9,10-tetramethoxyberbinium;   Formula=C21H22NO4;   InChI=1S/C21H22NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,9-12H,7-8H2,1-4H3/q+1;   InChIKey=QUCQEUCGKKTEBI-UHFFFAOYSA-N;   O,O-dimethyldemethyleneberberine;   SMILES=COc1cc2CC[n+]3cc4c(OC)c(OC)ccc4cc3-c2cc1OC;   berbericinine
 alt_id: CHEBI:14728;   CHEBI:25833;   CHEBI:7895
 xref: Beilstein:1555498;   CAS:3486-67-7;   KEGG:C05315;   KNApSAcK:C00001898;   KNApSAcK:C00027159;   LINCS:LSM-6625
 xref_mesh: MESH:C005413



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palmatine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases export
increases expression
ISO
EXP
palmatine inhibits the reaction [ABCB1A protein results in increased export of Fluorescent Dyes]
ABCB1A protein results in increased export of palmatine
palmatine results in increased expression of ABCB1A mRNA
CTD PMID:20410605 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression EXP palmatine results in increased expression of ABCB1B mRNA CTD PMID:20410605 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO palmatine results in increased expression of AHR mRNA CTD PMID:24583342 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects binding ISO palmatine binds to BIRC5 promoter CTD PMID:17968851 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO palmatine results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO palmatine results in decreased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO palmatine results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO palmatine results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO palmatine results in increased expression of CYP1A1 mRNA CTD PMID:24583342 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G H2ax H2A.X variant histone increases expression ISO palmatine results in increased expression of H2AX protein modified form CTD PMID:23747414 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO palmatine results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Top1 DNA topoisomerase I decreases activity ISO palmatine results in decreased activity of TOP1 protein CTD PMID:23747414 NCBI chr 3:149,293,658...149,375,405
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO palmatine results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
tetrahydropalmatine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcf1 ATP binding cassette subfamily F member 1 decreases expression ISO tetrahydropalmatine results in decreased expression of ABCF1 protein CTD PMID:20109541 NCBI chr20:2,802,519...2,815,433
Ensembl chr20:2,802,488...2,815,433
JBrowse link
G Acbd3 acyl-CoA binding domain containing 3 increases expression ISO tetrahydropalmatine results in increased expression of ACBD3 protein CTD PMID:20109541 NCBI chr13:92,455,813...92,484,556
Ensembl chr13:92,455,655...92,483,380
JBrowse link
G Acot9 acyl-CoA thioesterase 9 decreases expression ISO tetrahydropalmatine results in decreased expression of ACOT9 protein CTD PMID:20109541 NCBI chr  X:40,073,197...40,123,573
Ensembl chr  X:40,064,810...40,123,559
JBrowse link
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 increases expression ISO tetrahydropalmatine results in increased expression of ALDH5A1 protein CTD PMID:20109541 NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677
JBrowse link
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 increases expression ISO tetrahydropalmatine results in increased expression of AP2A1 protein CTD PMID:20109541 NCBI chr 1:95,384,303...95,414,249
Ensembl chr 1:95,384,309...95,414,147
JBrowse link
G Arhgap1 Rho GTPase activating protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of ARHGAP1 protein CTD PMID:20109541 NCBI chr 3:77,621,377...77,643,400
Ensembl chr 3:77,620,655...77,643,396
JBrowse link
G Arih1 ariadne RBR E3 ubiquitin protein ligase 1 decreases expression ISO tetrahydropalmatine results in decreased expression of ARIH1 protein CTD PMID:20109541 NCBI chr 8:59,777,378...59,879,762
Ensembl chr 8:59,777,379...59,880,245
JBrowse link
G Arpc3 actin related protein 2/3 complex, subunit 3 decreases expression ISO tetrahydropalmatine results in decreased expression of ARPC3 protein CTD PMID:20109541 NCBI chr12:34,172,780...34,186,651
Ensembl chr12:34,172,780...34,186,651
JBrowse link
G Arpp19 cAMP-regulated phosphoprotein 19 decreases expression ISO tetrahydropalmatine results in decreased expression of ARPP19 protein CTD PMID:20109541 NCBI chr 8:75,779,640...75,802,474
Ensembl chr 8:75,779,523...75,802,452
JBrowse link
G Atad3a ATPase family, AAA domain containing 3A increases expression ISO tetrahydropalmatine results in increased expression of ATAD3A protein CTD PMID:20109541 NCBI chr 5:166,350,302...166,370,492
Ensembl chr 5:166,350,304...166,370,482
JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 decreases expression ISO tetrahydropalmatine results in decreased expression of ATP2B1 protein CTD PMID:20109541 NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO tetrahydropalmatine results in increased expression of BAD protein CTD PMID:20109541 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO tetrahydropalmatine results in increased expression of BAX protein CTD PMID:20109541 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member decreases expression ISO tetrahydropalmatine results in decreased expression of BCAR1 protein CTD PMID:20109541 NCBI chr19:39,679,218...39,713,952
Ensembl chr19:39,679,204...39,713,907
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO tetrahydropalmatine results in decreased expression of BCL2 protein CTD PMID:20109541 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bzw1 basic leucine zipper and W2 domains 1 decreases expression ISO tetrahydropalmatine results in decreased expression of BZW1 protein CTD PMID:20109541 NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430
JBrowse link
G Cald1 caldesmon 1 decreases expression
increases expression
ISO tetrahydropalmatine results in decreased expression of CALD1 protein
tetrahydropalmatine results in increased expression of CALD1 protein
CTD PMID:20109541 NCBI chr 4:63,265,781...63,446,936
Ensembl chr 4:63,265,942...63,446,932
JBrowse link
G Calu calumenin decreases expression ISO tetrahydropalmatine results in decreased expression of CALU protein CTD PMID:20109541 NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593
JBrowse link
G Casp3 caspase 3 increases cleavage ISO tetrahydropalmatine results in increased cleavage of CASP3 protein CTD PMID:20109541 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cavin3 caveolae associated protein 3 decreases expression ISO tetrahydropalmatine results in decreased expression of CAVIN3 protein CTD PMID:20109541 NCBI chr 1:159,826,549...159,828,138
Ensembl chr 1:159,826,549...159,828,161
JBrowse link
G Cc2d1b coiled-coil and C2 domain containing 1B decreases expression ISO tetrahydropalmatine results in decreased expression of CC2D1B protein CTD PMID:20109541 NCBI chr 5:123,353,289...123,367,343
Ensembl chr 5:123,353,292...123,367,318
JBrowse link
G Ckap5 cytoskeleton associated protein 5 decreases expression ISO tetrahydropalmatine results in decreased expression of CKAP5 protein CTD PMID:20109541 NCBI chr 3:77,491,195...77,593,300
Ensembl chr 3:77,491,276...77,593,264
JBrowse link
G Clip1 CAP-GLY domain containing linker protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of CLIP1 protein CTD PMID:20109541 NCBI chr12:32,910,932...33,017,891
Ensembl chr12:32,910,977...33,017,884
JBrowse link
G Coa6 cytochrome c oxidase assembly factor 6 decreases expression ISO tetrahydropalmatine results in decreased expression of COA6 protein CTD PMID:20109541 NCBI chr19:54,395,682...54,398,918 JBrowse link
G Coasy Coenzyme A synthase decreases expression ISO tetrahydropalmatine results in decreased expression of COASY protein CTD PMID:20109541 NCBI chr10:86,014,566...86,018,849
Ensembl chr10:86,014,597...86,018,841
JBrowse link
G Cops2 COP9 signalosome subunit 2 decreases expression ISO tetrahydropalmatine results in decreased expression of COPS2 protein CTD PMID:20109541 NCBI chr 3:113,084,174...113,110,090
Ensembl chr 3:113,084,176...113,109,947
JBrowse link
G Cops3 COP9 signalosome subunit 3 decreases expression ISO tetrahydropalmatine results in decreased expression of COPS3 protein CTD PMID:20109541 NCBI chr10:44,618,115...44,652,807
Ensembl chr10:44,618,115...44,641,597
JBrowse link
G Cox6c cytochrome c oxidase subunit 6C increases expression ISO tetrahydropalmatine results in increased expression of COX6C protein CTD PMID:20109541 NCBI chr 7:67,129,265...67,142,001
Ensembl chr 7:67,111,024...67,141,963
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression ISO tetrahydropalmatine results in decreased expression of CPT1A protein CTD PMID:20109541 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Crip2 cysteine-rich protein 2 decreases expression ISO tetrahydropalmatine results in decreased expression of CRIP2 protein CTD PMID:20109541 NCBI chr 6:132,221,120...132,226,066
Ensembl chr 6:132,221,082...132,226,065
JBrowse link
G Cryz crystallin zeta decreases expression ISO tetrahydropalmatine results in decreased expression of CRYZ protein CTD PMID:20109541 NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758
JBrowse link
G Csde1 cold shock domain containing E1 decreases expression ISO tetrahydropalmatine results in decreased expression of CSDE1 protein CTD PMID:20109541 NCBI chr 2:190,546,015...190,582,790
Ensembl chr 2:190,554,980...190,582,784
JBrowse link
G Cstb cystatin B increases expression ISO tetrahydropalmatine results in increased expression of CSTB protein CTD PMID:20109541 NCBI chr20:10,245,462...10,247,505
Ensembl chr20:10,245,462...10,247,526
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression ISO tetrahydropalmatine results in decreased expression of CYP1A2 mRNA; tetrahydropalmatine results in decreased expression of CYP1A2 protein CTD PMID:28257954 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Dcaf7 DDB1 and CUL4 associated factor 7 decreases expression ISO tetrahydropalmatine results in decreased expression of DCAF7 protein CTD PMID:20109541 NCBI chr10:90,974,095...90,996,275
Ensembl chr10:90,974,095...90,996,275
JBrowse link
G Dctn2 dynactin subunit 2 decreases expression ISO tetrahydropalmatine results in decreased expression of DCTN2 protein CTD PMID:20109541 NCBI chr 7:63,092,061...63,107,560
Ensembl chr 7:63,092,057...63,108,543
JBrowse link
G Ddx19b DEAD-box helicase 19B decreases expression ISO tetrahydropalmatine results in decreased expression of DDX19B protein CTD PMID:20109541 NCBI chr19:38,968,215...38,998,907
Ensembl chr19:38,968,215...38,997,259
JBrowse link
G Ddx50 DExD-box helicase 50 decreases expression ISO tetrahydropalmatine results in decreased expression of DDX50 protein CTD PMID:20109541 NCBI chr20:30,561,623...30,591,324
Ensembl chr20:30,560,544...30,591,152
JBrowse link
G Decr2 2,4-dienoyl-CoA reductase 2 increases expression ISO tetrahydropalmatine results in increased expression of DECR2 protein CTD PMID:20109541 NCBI chr10:15,104,907...15,113,281 JBrowse link
G Dhx8 DEAH-box helicase 8 increases expression ISO tetrahydropalmatine results in increased expression of DHX8 protein CTD PMID:20109541 NCBI chr10:86,667,641...86,705,454
Ensembl chr10:86,667,834...86,705,137
JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 decreases expression ISO tetrahydropalmatine results in decreased expression of DNAJB11 protein CTD PMID:20109541 NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407
JBrowse link
G Dpp3 dipeptidylpeptidase 3 decreases expression ISO tetrahydropalmatine results in decreased expression of DPP3 protein CTD PMID:20109541 NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions ISO tetrahydropalmatine binds to and results in decreased activity of DRD1 protein CTD PMID:17361394 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO tetrahydropalmatine binds to and results in decreased activity of DRD2 protein CTD PMID:17361394 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd3 dopamine receptor D3 affects binding EXP tetrahydropalmatine binds to DRD3 protein CTD PMID:17361394 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Dync1i2 dynein cytoplasmic 1 intermediate chain 2 decreases expression ISO tetrahydropalmatine results in decreased expression of DYNC1I2 protein CTD PMID:20109541 NCBI chr 3:56,033,882...56,085,080
Ensembl chr 3:56,033,917...56,085,080
JBrowse link
G Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 decreases expression ISO tetrahydropalmatine results in decreased expression of DYNC1LI2 protein CTD PMID:20109541 NCBI chr19:531,783...554,670
Ensembl chr19:531,812...554,670
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 increases expression ISO tetrahydropalmatine results in increased expression of EEF1A1 protein CTD PMID:20109541 NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839
JBrowse link
G Eef1a2 eukaryotic translation elongation factor 1 alpha 2 decreases expression ISO tetrahydropalmatine results in decreased expression of EEF1A2 protein CTD PMID:20109541 NCBI chr 3:168,265,893...168,275,071 JBrowse link
G Eif1 eukaryotic translation initiation factor 1 decreases expression ISO tetrahydropalmatine results in decreased expression of EIF1 protein CTD PMID:20109541 NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327
JBrowse link
G Eif4a2 eukaryotic translation initiation factor 4A2 decreases expression ISO tetrahydropalmatine results in decreased expression of EIF4A2 protein CTD PMID:20109541 NCBI chr11:77,764,126...77,770,810
Ensembl chr11:77,764,124...77,770,781
JBrowse link
G Exoc8 exocyst complex component 8 decreases expression ISO tetrahydropalmatine results in decreased expression of EXOC8 protein CTD PMID:20109541 NCBI chr19:52,855,010...52,857,499
Ensembl chr19:52,852,578...52,857,491
JBrowse link
G Faf2 Fas associated factor family member 2 decreases expression ISO tetrahydropalmatine results in decreased expression of FAF2 protein CTD PMID:20109541 NCBI chr17:9,947,216...9,989,474
Ensembl chr17:9,947,220...9,989,485
JBrowse link
G Fah fumarylacetoacetate hydrolase decreases expression ISO tetrahydropalmatine results in decreased expression of FAH protein CTD PMID:20109541 NCBI chr 1:138,548,830...138,571,599
Ensembl chr 1:138,548,834...138,571,505
JBrowse link
G Fam136a family with sequence similarity 136, member A decreases expression ISO tetrahydropalmatine results in decreased expression of FAM136A protein CTD PMID:20109541 NCBI chr 4:118,805,129...118,811,046
Ensembl chr 4:118,805,127...118,811,047
JBrowse link
G Fkbp8 FKBP prolyl isomerase 8 decreases expression ISO tetrahydropalmatine results in decreased expression of FKBP8 protein CTD PMID:20109541 NCBI chr16:18,895,608...18,902,648
Ensembl chr16:18,893,576...18,902,612
JBrowse link
G Flywch2 FLYWCH family member 2 decreases expression ISO tetrahydropalmatine results in decreased expression of FLYWCH2 protein CTD PMID:20109541
G Fmr1 FMRP translational regulator 1 decreases expression ISO tetrahydropalmatine results in decreased expression of FMR1 protein CTD PMID:20109541 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050
JBrowse link
G Galk1 galactokinase 1 decreases expression ISO tetrahydropalmatine results in decreased expression of GALK1 protein CTD PMID:20109541 NCBI chr10:101,243,146...101,247,323
Ensembl chr10:101,235,994...101,247,337
JBrowse link
G Ganab glucosidase II alpha subunit decreases expression ISO tetrahydropalmatine results in decreased expression of GANAB protein CTD PMID:20109541 NCBI chr 1:205,793,810...205,813,701
Ensembl chr 1:205,793,895...205,813,695
JBrowse link
G Ggh gamma-glutamyl hydrolase increases expression ISO tetrahydropalmatine results in increased expression of GGH protein CTD PMID:20109541 NCBI chr 5:33,529,880...33,552,790
Ensembl chr 5:33,529,880...33,552,787
JBrowse link
G Glrx glutaredoxin decreases expression ISO tetrahydropalmatine results in decreased expression of GLRX protein CTD PMID:20109541 NCBI chr 2:5,341,873...5,351,686
Ensembl chr 2:5,341,885...5,351,680
JBrowse link
G Gmppb GDP-mannose pyrophosphorylase B increases expression ISO tetrahydropalmatine results in increased expression of GMPPB protein CTD PMID:20109541 NCBI chr 8:108,737,429...108,767,286
Ensembl chr 8:108,693,060...108,767,286
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression ISO tetrahydropalmatine results in decreased expression of GPX4 protein CTD PMID:20109541 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Gsn gelsolin decreases expression ISO tetrahydropalmatine results in decreased expression of GSN protein CTD PMID:20109541 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
JBrowse link
G Gtpbp4 GTP binding protein 4 decreases expression ISO tetrahydropalmatine results in decreased expression of GTPBP4 protein CTD PMID:20109541 NCBI chr17:61,308,033...61,328,184
Ensembl chr17:61,308,014...61,418,009
JBrowse link
G Hibch 3-hydroxyisobutyryl-CoA hydrolase increases expression ISO tetrahydropalmatine results in increased expression of HIBCH protein CTD PMID:20109541 NCBI chr 9:48,590,097...48,669,896
Ensembl chr 9:48,590,099...48,669,824
JBrowse link
G Hint2 histidine triad nucleotide binding protein 2 decreases expression ISO tetrahydropalmatine results in decreased expression of HINT2 protein CTD PMID:20109541 NCBI chr 5:57,904,613...57,906,868
Ensembl chr 5:57,904,614...57,907,097
JBrowse link
G Hk1 hexokinase 1 decreases expression
increases expression
ISO tetrahydropalmatine results in decreased expression of HK1 protein
tetrahydropalmatine results in increased expression of HK1 protein
CTD PMID:20109541 NCBI chr20:30,230,488...30,332,161
Ensembl chr20:30,230,486...30,332,131
JBrowse link
G Hmga1 high mobility group AT-hook 1 decreases expression ISO tetrahydropalmatine results in decreased expression of HMGA1 protein CTD PMID:20109541 NCBI chr20:5,611,088...5,618,755
Ensembl chr20:5,611,694...5,618,752
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression ISO tetrahydropalmatine results in decreased expression of HMOX1 protein CTD PMID:20109541 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnrnpul2 heterogeneous nuclear ribonucleoprotein U-like 2 increases expression ISO tetrahydropalmatine results in increased expression of HNRNPUL2 protein CTD PMID:20109541 NCBI chr 1:205,713,431...205,725,553
Ensembl chr 1:205,711,886...205,725,553
JBrowse link
G Igf2bp3 insulin-like growth factor 2 mRNA binding protein 3 decreases expression ISO tetrahydropalmatine results in decreased expression of IGF2BP3 protein CTD PMID:20109541 NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:78,060,494...78,194,865
JBrowse link
G Ipo9 importin 9 decreases expression ISO tetrahydropalmatine results in decreased expression of IPO9 protein CTD PMID:20109541 NCBI chr13:46,810,460...46,862,694
Ensembl chr13:46,813,171...46,862,673
JBrowse link
G Iqgap3 IQ motif containing GTPase activating protein 3 decreases expression ISO tetrahydropalmatine results in decreased expression of IQGAP3 protein CTD PMID:20109541 NCBI chr 2:173,542,151...173,583,956
Ensembl chr 2:173,542,110...173,583,956
JBrowse link
G Jpt2 Jupiter microtubule associated homolog 2 decreases expression ISO tetrahydropalmatine results in decreased expression of JPT2 protein CTD PMID:20109541 NCBI chr10:13,963,135...13,983,212
Ensembl chr10:13,963,137...13,983,170
JBrowse link
G Letm1 leucine zipper and EF-hand containing transmembrane protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of LETM1 protein CTD PMID:20109541 NCBI chr14:76,942,647...76,982,220
Ensembl chr14:76,942,729...76,984,904
JBrowse link
G Lta4h leukotriene A4 hydrolase decreases expression ISO tetrahydropalmatine results in decreased expression of LTA4H protein CTD PMID:20109541 NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600
JBrowse link
G Mak16 MAK16 homolog decreases expression ISO tetrahydropalmatine results in decreased expression of MAK16 protein CTD PMID:20109541 NCBI chr16:60,972,699...60,981,250
Ensembl chr16:60,972,697...60,983,243
JBrowse link
G Man1b1 mannosidase, alpha, class 1B, member 1 increases expression ISO tetrahydropalmatine results in increased expression of MAN1B1 protein CTD PMID:20109541 NCBI chr 3:8,143,877...8,165,007
Ensembl chr 3:8,143,381...8,165,006
JBrowse link
G Map1b microtubule-associated protein 1B increases expression ISO tetrahydropalmatine results in increased expression of MAP1B protein CTD PMID:20109541 NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 decreases expression ISO tetrahydropalmatine results in decreased expression of MAP2K2 protein CTD PMID:20109541 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
JBrowse link
G Metap2 methionyl aminopeptidase 2 decreases expression ISO tetrahydropalmatine results in decreased expression of METAP2 protein CTD PMID:20109541 NCBI chr 7:28,412,771...28,440,458
Ensembl chr 7:28,411,608...28,440,434
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO tetrahydropalmatine results in decreased expression of MTOR protein CTD PMID:20109541 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Ncaph non-SMC condensin I complex, subunit H increases expression ISO tetrahydropalmatine results in increased expression of NCAPH protein CTD PMID:20109541 NCBI chr 3:114,371,937...114,399,223
Ensembl chr 3:114,371,941...114,399,180
JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases expression ISO tetrahydropalmatine results in decreased expression of NCEH1 protein CTD PMID:20109541 NCBI chr 2:110,074,985...110,135,592
Ensembl chr 2:110,074,957...110,135,588
JBrowse link
G Ndufb5 NADH:ubiquinone oxidoreductase subunit B5 decreases expression ISO tetrahydropalmatine results in decreased expression of NDUFB5 protein CTD PMID:20109541 NCBI chr 2:115,519,248...115,533,589
Ensembl chr 2:115,519,154...115,533,589
JBrowse link
G Nelfe negative elongation factor complex member E decreases expression ISO tetrahydropalmatine results in decreased expression of NELFE protein CTD PMID:20109541 NCBI chr20:3,976,512...3,982,389
Ensembl chr20:3,976,518...3,982,355
JBrowse link
G Nfu1 NFU1 iron-sulfur cluster scaffold decreases expression ISO tetrahydropalmatine results in decreased expression of NFU1 protein CTD PMID:20109541 NCBI chr 4:119,458,981...119,480,162
Ensembl chr 4:119,459,061...119,480,373
JBrowse link
G Nipsnap1 nipsnap homolog 1 increases expression ISO tetrahydropalmatine results in increased expression of NIPSNAP1 protein CTD PMID:20109541 NCBI chr14:79,734,234...79,758,101
Ensembl chr14:79,734,209...79,758,098
JBrowse link
G Nubp2 nucleotide binding protein 2 decreases expression ISO tetrahydropalmatine results in decreased expression of NUBP2 protein CTD PMID:20109541 NCBI chr10:13,903,224...13,906,928
Ensembl chr10:13,903,224...13,906,969
JBrowse link
G Nufip2 nuclear FMR1 interacting protein 2 decreases expression ISO tetrahydropalmatine results in decreased expression of NUFIP2 protein CTD PMID:20109541 NCBI chr10:62,574,922...62,607,729
Ensembl chr10:62,574,882...62,600,346
JBrowse link
G Nup155 nucleoporin 155 decreases expression ISO tetrahydropalmatine results in decreased expression of NUP155 protein CTD PMID:20109541 NCBI chr 2:57,201,310...57,252,918
Ensembl chr 2:57,201,272...57,254,148
JBrowse link
G Palld palladin, cytoskeletal associated protein decreases expression ISO tetrahydropalmatine results in decreased expression of PALLD protein CTD PMID:20109541 NCBI chr16:28,228,006...28,621,349 JBrowse link
G Pawr pro-apoptotic WT1 regulator decreases expression ISO tetrahydropalmatine results in decreased expression of PAWR protein CTD PMID:20109541 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
JBrowse link
G Pds5a PDS5 cohesin associated factor A increases expression ISO tetrahydropalmatine results in increased expression of PDS5A protein CTD PMID:20109541 NCBI chr14:42,551,653...42,651,074
Ensembl chr14:42,552,647...42,648,669
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein increases expression ISO tetrahydropalmatine results in increased expression of PICALM protein CTD PMID:20109541 NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 decreases expression ISO tetrahydropalmatine results in decreased expression of PIN1 protein CTD PMID:20109541 NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785
JBrowse link
G Ppil3 peptidylprolyl isomerase like 3 decreases expression ISO tetrahydropalmatine results in decreased expression of PPIL3 protein CTD PMID:20109541 NCBI chr 9:59,966,405...59,980,147
Ensembl chr 9:59,964,919...59,979,886
JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta decreases expression ISO tetrahydropalmatine results in decreased expression of PPP2CB protein CTD PMID:20109541 NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
JBrowse link
G Praf2 PRA1 domain family, member 2 increases expression ISO tetrahydropalmatine results in increased expression of PRAF2 protein CTD PMID:20109541 NCBI chr  X:14,773,398...14,776,035
Ensembl chr  X:14,773,420...14,775,909
JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha decreases expression ISO tetrahydropalmatine results in decreased expression of PRKAR1A protein CTD PMID:20109541 NCBI chr10:94,621,042...94,639,534
Ensembl chr10:94,620,039...94,639,041
JBrowse link
G Prkca protein kinase C, alpha decreases expression ISO tetrahydropalmatine results in decreased expression of PRKCA protein CTD PMID:20109541 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prpf4 pre-mRNA processing factor 4 decreases expression ISO tetrahydropalmatine results in decreased expression of PRPF4 protein CTD PMID:20109541 NCBI chr 5:75,859,934...75,873,924
Ensembl chr 5:75,859,924...75,873,919
JBrowse link
G Prpsap1 phosphoribosyl pyrophosphate synthetase-associated protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of PRPSAP1 protein CTD PMID:20109541 NCBI chr10:101,701,094...101,750,753
Ensembl chr10:101,701,096...101,750,751
JBrowse link
G Pym1 PYM homolog 1, exon junction complex associated factor decreases expression ISO tetrahydropalmatine results in decreased expression of PYM1 protein CTD PMID:20109541 NCBI chr 7:1,177,746...1,200,899
Ensembl chr 7:1,178,008...1,198,937
JBrowse link
G Rab3gap1 RAB3 GTPase activating protein catalytic subunit 1 decreases expression ISO tetrahydropalmatine results in decreased expression of RAB3GAP1 protein CTD PMID:20109541 NCBI chr13:39,355,698...39,429,154
Ensembl chr13:39,352,247...39,429,169
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases expression ISO tetrahydropalmatine results in increased expression of RAF1 protein CTD PMID:20109541 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Ranbp2 RAN binding protein 2 decreases expression ISO tetrahydropalmatine results in decreased expression of RANBP2 protein CTD PMID:20109541 NCBI chr20:26,442,156...26,493,481
Ensembl chr20:26,442,217...26,493,481
JBrowse link
G Rbm39 RNA binding motif protein 39 decreases expression
increases expression
ISO tetrahydropalmatine results in decreased expression of RBM39 protein
tetrahydropalmatine results in increased expression of RBM39 protein
CTD PMID:20109541 NCBI chr 3:144,662,998...144,696,222
Ensembl chr 3:144,663,001...144,696,213
JBrowse link
G Reep5 receptor accessory protein 5 decreases expression ISO tetrahydropalmatine results in decreased expression of REEP5 protein CTD PMID:20109541 NCBI chr18:25,945,375...25,983,271
Ensembl chr18:25,945,381...25,976,509
JBrowse link
G Rfc4 replication factor C subunit 4 increases expression ISO tetrahydropalmatine results in increased expression of RFC4 protein CTD PMID:20109541 NCBI chr11:77,749,642...77,764,123
Ensembl chr11:77,749,638...77,764,122
JBrowse link
G Rhob ras homolog family member B decreases expression ISO tetrahydropalmatine results in decreased expression of RHOB protein CTD PMID:20109541 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
JBrowse link
G Rmnd5a required for meiotic nuclear division 5 homolog A increases expression ISO tetrahydropalmatine results in increased expression of RMND5A protein CTD PMID:20109541 NCBI chr 4:103,375,846...103,432,890
Ensembl chr 4:103,379,908...103,433,051
JBrowse link
G Rnf40 ring finger protein 40 decreases expression ISO tetrahydropalmatine results in decreased expression of RNF40 protein CTD PMID:20109541 NCBI chr 1:182,202,475...182,217,899
Ensembl chr 1:182,202,600...182,217,241
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 decreases expression ISO tetrahydropalmatine results in decreased expression of ROCK2 protein CTD PMID:20109541 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
JBrowse link
G Rpa2 replication protein A2 decreases expression ISO tetrahydropalmatine results in decreased expression of RPA2 protein CTD PMID:20109541 NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350
JBrowse link
G Rps28 ribosomal protein S28 decreases expression ISO tetrahydropalmatine results in decreased expression of RPS28 protein CTD PMID:20109541 NCBI chr 7:14,607,801...14,609,170
Ensembl chr 7:14,607,801...14,609,170
JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 increases expression ISO tetrahydropalmatine results in increased expression of RPS6KA3 protein CTD PMID:20109541 NCBI chr  X:35,517,306...35,623,296
Ensembl chr  X:35,517,306...35,623,207
JBrowse link
G Septin11 septin 11 decreases expression ISO tetrahydropalmatine results in decreased expression of SEPTIN11 protein CTD PMID:20109541 NCBI chr14:14,844,759...14,990,856
Ensembl chr14:14,844,580...14,990,853
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO tetrahydropalmatine inhibits the reaction [SLC22A1 protein results in increased uptake of Monocrotaline]; tetrahydropalmatine inhibits the reaction [SLC22A1 protein results in increased uptake of retrorsine] CTD PMID:23831208 PMID:24799337 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc25a10 solute carrier family 25 member 10 increases expression ISO tetrahydropalmatine results in increased expression of SLC25A10 protein CTD PMID:20109541 NCBI chr10:105,765,598...105,775,159
Ensembl chr10:105,765,372...105,773,556
JBrowse link
G Smarca5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 decreases expression ISO tetrahydropalmatine results in decreased expression of SMARCA5 protein CTD PMID:20109541 NCBI chr19:27,271,918...27,304,594
Ensembl chr19:27,271,148...27,304,594
JBrowse link
G Sms spermine synthase decreases expression ISO tetrahydropalmatine results in decreased expression of SMS protein CTD PMID:20109541 NCBI chr  X:37,516,949...37,572,657
Ensembl chr  X:37,516,931...37,570,822
JBrowse link
G Sncg synuclein, gamma decreases expression ISO tetrahydropalmatine results in decreased expression of SNCG protein CTD PMID:20109541 NCBI chr16:9,700,513...9,705,751
Ensembl chr16:9,700,514...9,705,368
JBrowse link
G Snrpe small nuclear ribonucleoprotein polypeptide E decreases expression ISO tetrahydropalmatine results in decreased expression of SNRPE protein CTD PMID:20109541 NCBI chr13:45,050,986...45,057,231
Ensembl chr13:45,050,986...45,057,310
JBrowse link
G Snw1 SNW domain containing 1 decreases expression ISO tetrahydropalmatine results in decreased expression of SNW1 protein CTD PMID:20109541 NCBI chr 6:107,095,450...107,119,536
Ensembl chr 6:107,095,457...107,119,536
JBrowse link
G Snx1 sorting nexin 1 decreases expression ISO tetrahydropalmatine results in decreased expression of SNX1 protein CTD PMID:20109541 NCBI chr 8:66,630,086...66,670,418
Ensembl chr 8:66,630,086...66,670,360
JBrowse link
G Snx2 sorting nexin 2 decreases expression ISO tetrahydropalmatine results in decreased expression of SNX2 protein CTD PMID:20109541 NCBI chr18:46,602,223...46,643,870
Ensembl chr18:46,602,284...46,643,865
JBrowse link
G Spdl1 spindle apparatus coiled-coil protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of SPDL1 protein CTD PMID:20109541 NCBI chr10:19,269,125...19,294,213
Ensembl chr10:19,269,127...19,294,127
JBrowse link
G Sri sorcin decreases expression ISO tetrahydropalmatine results in decreased expression of SRI protein CTD PMID:20109541 NCBI chr 4:25,973,493...25,997,879
Ensembl chr 4:25,966,750...25,998,077
JBrowse link
G Srp19 signal recognition particle 19 decreases expression ISO tetrahydropalmatine results in decreased expression of SRP19 protein CTD PMID:20109541 NCBI chr18:25,931,734...25,937,974
Ensembl chr18:25,931,589...25,938,017
JBrowse link
G Srp68 signal recognition particle 68 decreases expression ISO tetrahydropalmatine results in decreased expression of SRP68 protein CTD PMID:20109541 NCBI chr10:101,481,213...101,508,035
Ensembl chr10:101,481,212...101,508,035
JBrowse link
G Srpra SRP receptor subunit alpha decreases expression ISO tetrahydropalmatine results in decreased expression of SRPRA protein CTD PMID:20109541 NCBI chr 8:33,560,365...33,566,458
Ensembl chr 8:33,560,348...33,566,470
JBrowse link
G Stat1 signal transducer and activator of transcription 1 increases expression ISO tetrahydropalmatine results in increased expression of STAT1 protein CTD PMID:20109541 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Stxbp1 syntaxin binding protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of STXBP1 protein CTD PMID:20109541 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369
JBrowse link
G Swap70 switching B-cell complex subunit SWAP70 increases expression ISO tetrahydropalmatine results in increased expression of SWAP70 protein CTD PMID:20109541 NCBI chr 1:164,267,588...164,328,796
Ensembl chr 1:164,267,609...164,328,794
JBrowse link
G Syvn1 synoviolin 1 decreases expression ISO tetrahydropalmatine results in decreased expression of SYVN1 protein CTD PMID:20109541 NCBI chr 1:203,339,235...203,346,137
Ensembl chr 1:203,339,619...203,346,152
JBrowse link
G Tma7 translation machinery associated 7 homolog decreases expression ISO tetrahydropalmatine results in decreased expression of TMA7 protein CTD PMID:20109541 NCBI chr 8:109,726,213...109,730,902
Ensembl chr 8:109,726,196...109,735,474
JBrowse link
G Tmed4 transmembrane p24 trafficking protein 4 decreases expression ISO tetrahydropalmatine results in decreased expression of TMED4 protein CTD PMID:20109541 NCBI chr14:81,125,049...81,129,665
Ensembl chr14:81,125,053...81,129,631
JBrowse link
G Top1 DNA topoisomerase I increases expression ISO tetrahydropalmatine results in increased expression of TOP1 protein CTD PMID:20109541 NCBI chr 3:149,293,658...149,375,405
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Tsnax translin-associated factor X decreases expression ISO tetrahydropalmatine results in decreased expression of TSNAX protein CTD PMID:20109541 NCBI chr19:52,975,848...52,989,886
Ensembl chr19:52,975,659...52,989,878
JBrowse link
G Tsr2 TSR2, ribosome maturation factor increases expression ISO tetrahydropalmatine results in increased expression of TSR2 protein CTD PMID:20109541 NCBI chr  X:20,064,102...20,072,673
Ensembl chr  X:20,064,103...20,072,620
JBrowse link
G Ttc37 tetratricopeptide repeat domain 37 decreases expression ISO tetrahydropalmatine results in decreased expression of TTC37 protein CTD PMID:20109541 NCBI chr 2:5,631,544...5,783,643
Ensembl chr 2:5,631,635...5,751,626
JBrowse link
G Uap1 UDP-N-acetylglucosamine pyrophosphorylase 1 increases expression ISO tetrahydropalmatine results in increased expression of UAP1 protein CTD PMID:20109541 NCBI chr13:82,342,946...82,377,558
Ensembl chr13:82,342,946...82,377,469
JBrowse link
G Vps45 vacuolar protein sorting 45 homolog increases expression ISO tetrahydropalmatine results in increased expression of VPS45 protein CTD PMID:20109541 NCBI chr 2:183,555,919...183,616,312
Ensembl chr 2:183,555,921...183,616,295
JBrowse link
G Wdhd1 WD repeat and HMG-box DNA binding protein 1 increases expression ISO tetrahydropalmatine results in increased expression of WDHD1 protein CTD PMID:20109541 NCBI chr15:20,478,310...20,523,106
Ensembl chr15:20,489,291...20,523,096
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      biological role 19773
        biochemical role 19390
          metabolite 19367
            eukaryotic metabolite 19054
              plant metabolite 17458
                palmatine 159
                  tetrahydropalmatine 147
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic molecule 19572
                              organic cyclic compound 19366
                                organic heterocyclic compound 18604
                                  organonitrogen heterocyclic compound 17670
                                    dibenzoquinolizine 361
                                      berberine alkaloid 361
                                        palmatine 159
                                          tetrahydropalmatine 147
paths to the root