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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:palmatine
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Accession:CHEBI:16096 term browser browse the term
Definition:A berberine alkaloid that has formula C21H22NO4.
Synonyms:exact_synonym: 2,3,9,10-tetramethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium
 related_synonym: 5,6-Dihydro-2,3,9,10-tetramethoxydibenzo[a,g]quinolizinium;   7,8,13,13a-tetrahydro-2,3,9,10-tetramethoxyberbinium;   Formula=C21H22NO4;   InChI=1S/C21H22NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,9-12H,7-8H2,1-4H3/q+1;   InChIKey=QUCQEUCGKKTEBI-UHFFFAOYSA-N;   O,O-dimethyldemethyleneberberine;   SMILES=COc1cc2CC[n+]3cc4c(OC)c(OC)ccc4cc3-c2cc1OC;   berbericinine
 alt_id: CHEBI:14728;   CHEBI:25833;   CHEBI:7895
 xref: Beilstein:1555498;   CAS:3486-67-7;   KEGG:C05315;   KNApSAcK:C00001898;   KNApSAcK:C00027159;   LINCS:LSM-6625
 xref_mesh: MESH:C005413


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palmatine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases export
increases expression
ISO
EXP
palmatine inhibits the reaction [ABCB1A protein results in increased export of Fluorescent Dyes]
ABCB1A protein results in increased export of palmatine
palmatine results in increased expression of ABCB1A mRNA
CTD PMID:20410605 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression EXP palmatine results in increased expression of ABCB1B mRNA CTD PMID:20410605 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO palmatine results in increased expression of AHR mRNA CTD PMID:24583342 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects binding ISO palmatine binds to BIRC5 promoter CTD PMID:17968851 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO palmatine results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO palmatine results in decreased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO palmatine results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO palmatine results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO palmatine results in increased expression of CYP1A1 mRNA CTD PMID:24583342 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G H2ax H2A.X variant histone increases expression ISO palmatine results in increased expression of H2AX protein modified form CTD PMID:23747414 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO palmatine results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Top1 DNA topoisomerase I decreases activity ISO palmatine results in decreased activity of TOP1 protein CTD PMID:23747414 NCBI chr 3:156,635,688...156,717,686
Ensembl chr 3:156,642,464...156,717,686
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO palmatine results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
tetrahydropalmatine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcf1 ATP binding cassette subfamily F member 1 decreases expression ISO tetrahydropalmatine results in decreased expression of ABCF1 protein CTD PMID:20109541 NCBI chr20:3,309,914...3,322,828
Ensembl chr20:3,309,899...3,322,825
JBrowse link
G Acbd3 acyl-CoA binding domain containing 3 increases expression ISO tetrahydropalmatine results in increased expression of ACBD3 protein CTD PMID:20109541 NCBI chr13:99,004,942...99,035,520
Ensembl chr13:99,004,942...99,035,519
JBrowse link
G Acot9 acyl-CoA thioesterase 9 decreases expression ISO tetrahydropalmatine results in decreased expression of ACOT9 protein CTD PMID:20109541 NCBI chr  X:43,543,069...43,592,200
Ensembl chr  X:43,543,070...43,592,200
JBrowse link
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 increases expression ISO tetrahydropalmatine results in increased expression of ALDH5A1 protein CTD PMID:20109541 NCBI chr17:42,133,076...42,159,413
Ensembl chr17:42,133,076...42,159,413
JBrowse link
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 increases expression ISO tetrahydropalmatine results in increased expression of AP2A1 protein CTD PMID:20109541 NCBI chr 1:100,896,582...100,926,443
Ensembl chr 1:100,896,947...100,926,335
JBrowse link
G Arhgap1 Rho GTPase activating protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of ARHGAP1 protein CTD PMID:20109541 NCBI chr 3:80,555,196...80,576,881
Ensembl chr 3:80,555,196...80,576,856
JBrowse link
G Arih1 ariadne RBR E3 ubiquitin protein ligase 1 decreases expression ISO tetrahydropalmatine results in decreased expression of ARIH1 protein CTD PMID:20109541 NCBI chr 8:64,166,359...64,268,555
Ensembl chr 8:64,166,360...64,268,555
JBrowse link
G Arpc3 actin related protein 2/3 complex, subunit 3 decreases expression ISO tetrahydropalmatine results in decreased expression of ARPC3 protein CTD PMID:20109541 NCBI chr12:39,653,951...39,667,817
Ensembl chr12:39,653,953...39,667,849
JBrowse link
G Arpp19 cAMP-regulated phosphoprotein 19 decreases expression ISO tetrahydropalmatine results in decreased expression of ARPP19 protein CTD PMID:20109541 NCBI chr 8:81,949,577...81,972,054
Ensembl chr 8:81,949,877...81,968,589
JBrowse link
G Atad3a ATPase family, AAA domain containing 3A increases expression ISO tetrahydropalmatine results in increased expression of ATAD3A protein CTD PMID:20109541 NCBI chr 5:173,189,590...173,209,809
Ensembl chr 5:173,189,592...173,209,768
JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 decreases expression ISO tetrahydropalmatine results in decreased expression of ATP2B1 protein CTD PMID:20109541 NCBI chr 7:41,114,606...41,223,138
Ensembl chr 7:41,114,697...41,220,579
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO tetrahydropalmatine results in increased expression of BAD protein CTD PMID:20109541 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO tetrahydropalmatine results in increased expression of BAX protein CTD PMID:20109541 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member decreases expression ISO tetrahydropalmatine results in decreased expression of BCAR1 protein CTD PMID:20109541 NCBI chr19:43,932,543...43,967,452
Ensembl chr19:43,932,554...43,955,783
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO tetrahydropalmatine results in decreased expression of BCL2 protein CTD PMID:20109541 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bzw1 basic leucine zipper and W2 domains 1 decreases expression ISO tetrahydropalmatine results in decreased expression of BZW1 protein CTD PMID:20109541 NCBI chr 9:65,279,675...65,293,471
Ensembl chr 9:65,279,675...65,291,651
JBrowse link
G Cald1 caldesmon 1 decreases expression
increases expression
ISO tetrahydropalmatine results in decreased expression of CALD1 protein
tetrahydropalmatine results in increased expression of CALD1 protein
CTD PMID:20109541 NCBI chr 4:62,103,948...62,291,375
Ensembl chr 4:62,220,736...62,291,489
JBrowse link
G Calu calumenin decreases expression ISO tetrahydropalmatine results in decreased expression of CALU protein CTD PMID:20109541 NCBI chr 4:56,625,611...56,653,112
Ensembl chr 4:56,625,561...56,653,111
JBrowse link
G Casp3 caspase 3 increases cleavage ISO tetrahydropalmatine results in increased cleavage of CASP3 protein CTD PMID:20109541 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cavin3 caveolae associated protein 3 decreases expression ISO tetrahydropalmatine results in decreased expression of CAVIN3 protein CTD PMID:20109541 NCBI chr 1:170,317,099...170,318,688
Ensembl chr 1:170,317,113...170,318,935
JBrowse link
G Cc2d1b coiled-coil and C2 domain containing 1B decreases expression ISO tetrahydropalmatine results in decreased expression of CC2D1B protein CTD PMID:20109541 NCBI chr 5:128,215,711...128,229,762
Ensembl chr 5:128,215,711...128,229,737
JBrowse link
G Ckap5 cytoskeleton associated protein 5 decreases expression ISO tetrahydropalmatine results in decreased expression of CKAP5 protein CTD PMID:20109541 NCBI chr 3:80,424,320...80,526,583
Ensembl chr 3:80,468,154...80,526,593
JBrowse link
G Clip1 CAP-GLY domain containing linker protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of CLIP1 protein CTD PMID:20109541 NCBI chr12:38,345,203...38,452,650
Ensembl chr12:38,345,456...38,452,652
JBrowse link
G Coa6 cytochrome c oxidase assembly factor 6 decreases expression ISO tetrahydropalmatine results in decreased expression of COA6 protein CTD PMID:20109541 NCBI chr19:59,327,328...59,333,706
Ensembl chr19:59,328,960...59,331,192
JBrowse link
G Coasy Coenzyme A synthase decreases expression ISO tetrahydropalmatine results in decreased expression of COASY protein CTD PMID:20109541 NCBI chr10:88,992,413...88,996,677
Ensembl chr10:88,992,487...88,996,676
JBrowse link
G Cops2 COP9 signalosome subunit 2 decreases expression ISO tetrahydropalmatine results in decreased expression of COPS2 protein CTD PMID:20109541 NCBI chr 3:118,109,394...118,137,125
Ensembl chr 3:118,109,406...118,137,191
JBrowse link
G Cops3 COP9 signalosome subunit 3 decreases expression ISO tetrahydropalmatine results in decreased expression of COPS3 protein CTD PMID:20109541 NCBI chr10:46,182,680...46,206,083
Ensembl chr10:46,182,687...46,206,135
JBrowse link
G Cox6c cytochrome c oxidase subunit 6C increases expression ISO tetrahydropalmatine results in increased expression of COX6C protein CTD PMID:20109541 NCBI chr 7:74,723,177...74,735,650
Ensembl chr 7:74,723,179...74,735,650
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression ISO tetrahydropalmatine results in decreased expression of CPT1A protein CTD PMID:20109541 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Crip2 cysteine-rich protein 2 decreases expression ISO tetrahydropalmatine results in decreased expression of CRIP2 protein CTD PMID:20109541 NCBI chr 6:137,953,545...137,958,491
Ensembl chr 6:137,953,545...137,958,490
JBrowse link
G Cryz crystallin zeta decreases expression ISO tetrahydropalmatine results in decreased expression of CRYZ protein CTD PMID:20109541 NCBI chr 2:260,884,315...260,911,827
Ensembl chr 2:260,884,337...260,911,792
JBrowse link
G Csde1 cold shock domain containing E1 decreases expression ISO tetrahydropalmatine results in decreased expression of CSDE1 protein CTD PMID:20109541 NCBI chr 2:205,525,194...205,552,987
Ensembl chr 2:205,525,204...205,552,991
JBrowse link
G Cstb cystatin B increases expression ISO tetrahydropalmatine results in increased expression of CSTB protein CTD PMID:20109541 NCBI chr20:10,966,357...10,968,399
Ensembl chr20:10,966,331...10,968,432
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression ISO tetrahydropalmatine results in decreased expression of CYP1A2 mRNA; tetrahydropalmatine results in decreased expression of CYP1A2 protein CTD PMID:28257954 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Dcaf7 DDB1 and CUL4 associated factor 7 decreases expression ISO tetrahydropalmatine results in decreased expression of DCAF7 protein CTD PMID:20109541 NCBI chr10:94,231,585...94,254,046
Ensembl chr10:94,231,585...94,254,046
JBrowse link
G Dctn2 dynactin subunit 2 decreases expression ISO tetrahydropalmatine results in decreased expression of DCTN2 protein CTD PMID:20109541 NCBI chr 7:70,555,953...70,571,433
Ensembl chr 7:70,556,019...70,572,614
JBrowse link
G Ddx19b DEAD-box helicase 19B decreases expression ISO tetrahydropalmatine results in decreased expression of DDX19B protein CTD PMID:20109541 NCBI chr19:43,217,199...43,246,196
Ensembl chr19:43,217,161...43,275,287
JBrowse link
G Ddx50 DExD-box helicase 50 decreases expression ISO tetrahydropalmatine results in decreased expression of DDX50 protein CTD PMID:20109541 NCBI chr20:32,239,736...32,269,522
Ensembl chr20:32,239,748...32,269,145
JBrowse link
G Decr2 2,4-dienoyl-CoA reductase 2 increases expression ISO tetrahydropalmatine results in increased expression of DECR2 protein CTD PMID:20109541 NCBI chr10:15,451,850...15,460,227
Ensembl chr10:15,431,638...15,465,413
JBrowse link
G Dhx8 DEAH-box helicase 8 increases expression ISO tetrahydropalmatine results in increased expression of DHX8 protein CTD PMID:20109541 NCBI chr10:89,645,979...89,683,839
Ensembl chr10:89,645,973...89,683,446
JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 decreases expression ISO tetrahydropalmatine results in decreased expression of DNAJB11 protein CTD PMID:20109541 NCBI chr11:81,741,342...81,757,806
Ensembl chr11:81,741,297...81,757,813
JBrowse link
G Dpp3 dipeptidylpeptidase 3 decreases expression ISO tetrahydropalmatine results in decreased expression of DPP3 protein CTD PMID:20109541 NCBI chr 1:220,166,124...220,189,762
Ensembl chr 1:220,166,127...220,188,541
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions ISO tetrahydropalmatine binds to and results in decreased activity of DRD1 protein CTD PMID:17361394 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO tetrahydropalmatine binds to and results in decreased activity of DRD2 protein CTD PMID:17361394 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd3 dopamine receptor D3 affects binding EXP tetrahydropalmatine binds to DRD3 protein CTD PMID:17361394 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Dync1i2 dynein cytoplasmic 1 intermediate chain 2 decreases expression ISO tetrahydropalmatine results in decreased expression of DYNC1I2 protein CTD PMID:20109541 NCBI chr 3:57,817,677...57,868,854
Ensembl chr 3:57,817,693...57,868,854
JBrowse link
G Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 decreases expression ISO tetrahydropalmatine results in decreased expression of DYNC1LI2 protein CTD PMID:20109541 NCBI chr19:740,007...762,897
Ensembl chr19:740,028...762,897
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 increases expression ISO tetrahydropalmatine results in increased expression of EEF1A1 protein CTD PMID:20109541 NCBI chr 8:85,838,594...85,841,816
Ensembl chr 8:85,838,869...85,840,818
JBrowse link
G Eef1a2 eukaryotic translation elongation factor 1 alpha 2 decreases expression ISO tetrahydropalmatine results in decreased expression of EEF1A2 protein CTD PMID:20109541 NCBI chr 3:176,657,104...176,666,282
Ensembl chr 3:176,657,107...176,666,282
JBrowse link
G Eif1 eukaryotic translation initiation factor 1 decreases expression ISO tetrahydropalmatine results in decreased expression of EIF1 protein CTD PMID:20109541 NCBI chr10:88,227,455...88,229,546
Ensembl chr10:88,227,360...88,229,765
JBrowse link
G Eif4a2 eukaryotic translation initiation factor 4A2 decreases expression ISO tetrahydropalmatine results in decreased expression of EIF4A2 protein CTD PMID:20109541 NCBI chr11:81,373,047...81,379,680
Ensembl chr11:81,373,048...81,379,871
JBrowse link
G Exoc8 exocyst complex component 8 decreases expression ISO tetrahydropalmatine results in decreased expression of EXOC8 protein CTD PMID:20109541 NCBI chr19:57,647,305...57,649,794
Ensembl chr19:57,647,291...57,649,827
JBrowse link
G Faf2 Fas associated factor family member 2 decreases expression ISO tetrahydropalmatine results in decreased expression of FAF2 protein CTD PMID:20109541 NCBI chr17:10,485,650...10,527,886
Ensembl chr17:10,485,642...10,527,864
JBrowse link
G Fah fumarylacetoacetate hydrolase decreases expression ISO tetrahydropalmatine results in decreased expression of FAH protein CTD PMID:20109541 NCBI chr 1:146,713,663...146,736,339
Ensembl chr 1:146,713,676...146,736,261
JBrowse link
G Fam136a family with sequence similarity 136, member A decreases expression ISO tetrahydropalmatine results in decreased expression of FAM136A protein CTD PMID:20109541 NCBI chr 4:118,160,147...118,166,062
Ensembl chr 4:118,160,147...118,166,062
JBrowse link
G Fkbp8 FKBP prolyl isomerase 8 decreases expression ISO tetrahydropalmatine results in decreased expression of FKBP8 protein CTD PMID:20109541 NCBI chr16:20,645,956...20,652,890
Ensembl chr16:20,645,957...20,652,889
JBrowse link
G Flywch2 FLYWCH family member 2 decreases expression ISO tetrahydropalmatine results in decreased expression of FLYWCH2 protein CTD PMID:20109541
G Fmr1 FMRP translational regulator 1 decreases expression ISO tetrahydropalmatine results in decreased expression of FMR1 protein CTD PMID:20109541 NCBI chr  X:154,684,924...154,722,369
Ensembl chr  X:154,684,935...154,722,314
JBrowse link
G Galk1 galactokinase 1 decreases expression ISO tetrahydropalmatine results in decreased expression of GALK1 protein CTD PMID:20109541 NCBI chr10:104,560,322...104,564,499
Ensembl chr10:104,560,303...104,564,480
JBrowse link
G Ganab glucosidase II alpha subunit decreases expression ISO tetrahydropalmatine results in decreased expression of GANAB protein CTD PMID:20109541 NCBI chr 1:225,096,558...225,116,384
Ensembl chr 1:225,096,598...225,116,378
JBrowse link
G Ggh gamma-glutamyl hydrolase increases expression ISO tetrahydropalmatine results in increased expression of GGH protein CTD PMID:20109541 NCBI chr 5:34,040,258...34,063,369
Ensembl chr 5:34,040,258...34,063,361
JBrowse link
G Glrx glutaredoxin decreases expression ISO tetrahydropalmatine results in decreased expression of GLRX protein CTD PMID:20109541 NCBI chr 2:2,606,032...2,615,944
Ensembl chr 2:2,605,996...2,615,944
JBrowse link
G Gmppb GDP-mannose pyrophosphorylase B increases expression ISO tetrahydropalmatine results in increased expression of GMPPB protein CTD PMID:20109541 NCBI chr 8:116,826,251...116,856,159
Ensembl chr 8:116,826,680...116,856,159
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression ISO tetrahydropalmatine results in decreased expression of GPX4 protein CTD PMID:20109541 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Gsn gelsolin decreases expression ISO tetrahydropalmatine results in decreased expression of GSN protein CTD PMID:20109541 NCBI chr 3:14,456,106...14,508,922
Ensembl chr 3:14,467,330...14,508,911
JBrowse link
G Gtpbp4 GTP binding protein 4 decreases expression ISO tetrahydropalmatine results in decreased expression of GTPBP4 protein CTD PMID:20109541 NCBI chr17:63,111,086...63,145,618
Ensembl chr17:63,110,254...63,145,577
JBrowse link
G Hibch 3-hydroxyisobutyryl-CoA hydrolase increases expression ISO tetrahydropalmatine results in increased expression of HIBCH protein CTD PMID:20109541 NCBI chr 9:53,446,185...53,526,727
Ensembl chr 9:53,446,194...53,526,728
JBrowse link
G Hint2 histidine triad nucleotide binding protein 2 decreases expression ISO tetrahydropalmatine results in decreased expression of HINT2 protein CTD PMID:20109541 NCBI chr 5:59,150,344...59,152,599
Ensembl chr 5:59,150,345...59,152,599
JBrowse link
G Hk1 hexokinase 1 decreases expression
increases expression
ISO tetrahydropalmatine results in decreased expression of HK1 protein
tetrahydropalmatine results in increased expression of HK1 protein
CTD PMID:20109541 NCBI chr20:31,911,460...31,979,780
Ensembl chr20:31,912,262...31,956,649
JBrowse link
G Hmga1 high mobility group AT-hook 1 decreases expression ISO tetrahydropalmatine results in decreased expression of HMGA1 protein CTD PMID:20109541 NCBI chr20:7,132,501...7,140,155
Ensembl chr20:7,136,007...7,138,980
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression ISO tetrahydropalmatine results in decreased expression of HMOX1 protein CTD PMID:20109541 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnrnpul2 heterogeneous nuclear ribonucleoprotein U-like 2 increases expression ISO tetrahydropalmatine results in increased expression of HNRNPUL2 protein CTD PMID:20109541 NCBI chr 1:225,015,722...225,027,640
Ensembl chr 1:225,015,616...225,027,710
JBrowse link
G Igf2bp3 insulin-like growth factor 2 mRNA binding protein 3 decreases expression ISO tetrahydropalmatine results in decreased expression of IGF2BP3 protein CTD PMID:20109541 NCBI chr 4:78,744,683...78,879,457
Ensembl chr 4:78,746,547...78,879,294
JBrowse link
G Ipo9 importin 9 decreases expression ISO tetrahydropalmatine results in decreased expression of IPO9 protein CTD PMID:20109541 NCBI chr13:52,203,384...52,256,196
Ensembl chr13:52,207,435...52,256,196
JBrowse link
G Iqgap3 IQ motif containing GTPase activating protein 3 decreases expression ISO tetrahydropalmatine results in decreased expression of IQGAP3 protein CTD PMID:20109541 NCBI chr 2:187,447,477...187,489,630
Ensembl chr 2:187,447,501...187,489,630
JBrowse link
G Jpt2 Jupiter microtubule associated homolog 2 decreases expression ISO tetrahydropalmatine results in decreased expression of JPT2 protein CTD PMID:20109541 NCBI chr10:14,304,108...14,324,170
Ensembl chr10:14,304,104...14,324,211
JBrowse link
G Letm1 leucine zipper and EF-hand containing transmembrane protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of LETM1 protein CTD PMID:20109541 NCBI chr14:82,227,790...82,267,298
Ensembl chr14:82,227,708...82,267,350
JBrowse link
G Lta4h leukotriene A4 hydrolase decreases expression ISO tetrahydropalmatine results in decreased expression of LTA4H protein CTD PMID:20109541 NCBI chr 7:34,288,333...34,320,243
Ensembl chr 7:34,288,365...34,320,235
JBrowse link
G Mak16 MAK16 homolog decreases expression ISO tetrahydropalmatine results in decreased expression of MAK16 protein CTD PMID:20109541 NCBI chr16:64,729,254...64,737,807
Ensembl chr16:64,729,221...64,737,807
JBrowse link
G Man1b1 mannosidase, alpha, class 1B, member 1 increases expression ISO tetrahydropalmatine results in increased expression of MAN1B1 protein CTD PMID:20109541 NCBI chr 3:2,547,259...2,569,051
Ensembl chr 3:2,547,986...2,569,049
JBrowse link
G Map1b microtubule-associated protein 1B increases expression ISO tetrahydropalmatine results in increased expression of MAP1B protein CTD PMID:20109541 NCBI chr 2:29,675,391...29,768,750
Ensembl chr 2:29,675,391...29,768,750
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 decreases expression ISO tetrahydropalmatine results in decreased expression of MAP2K2 protein CTD PMID:20109541 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
JBrowse link
G Metap2 methionyl aminopeptidase 2 decreases expression ISO tetrahydropalmatine results in decreased expression of METAP2 protein CTD PMID:20109541 NCBI chr 7:34,762,241...34,789,456
Ensembl chr 7:34,762,231...34,789,479
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO tetrahydropalmatine results in decreased expression of MTOR protein CTD PMID:20109541 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Ncaph non-SMC condensin I complex, subunit H increases expression ISO tetrahydropalmatine results in increased expression of NCAPH protein CTD PMID:20109541 NCBI chr 3:119,583,798...119,611,148
Ensembl chr 3:119,583,648...119,611,136
JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases expression ISO tetrahydropalmatine results in decreased expression of NCEH1 protein CTD PMID:20109541 NCBI chr 2:112,868,834...112,932,622
Ensembl chr 2:112,868,707...112,934,953
JBrowse link
G Ndufb5 NADH:ubiquinone oxidoreductase subunit B5 decreases expression ISO tetrahydropalmatine results in decreased expression of NDUFB5 protein CTD PMID:20109541 NCBI chr 2:119,139,717...119,153,753
Ensembl chr 2:119,139,717...119,153,753
JBrowse link
G Nelfe negative elongation factor complex member E decreases expression ISO tetrahydropalmatine results in decreased expression of NELFE protein CTD PMID:20109541 NCBI chr20:4,530,328...4,536,085
Ensembl chr20:4,530,342...4,536,209
JBrowse link
G Nfu1 NFU1 iron-sulfur cluster scaffold decreases expression ISO tetrahydropalmatine results in decreased expression of NFU1 protein CTD PMID:20109541 NCBI chr 4:118,814,284...118,834,955
Ensembl chr 4:118,814,284...118,834,955
JBrowse link
G Nipsnap1 nipsnap homolog 1 increases expression ISO tetrahydropalmatine results in increased expression of NIPSNAP1 protein CTD PMID:20109541 NCBI chr14:85,113,578...85,137,457
Ensembl chr14:85,113,578...85,137,454
JBrowse link
G Nubp2 nucleotide binding protein 2 decreases expression ISO tetrahydropalmatine results in decreased expression of NUBP2 protein CTD PMID:20109541 NCBI chr10:14,244,201...14,247,930
Ensembl chr10:14,244,203...14,247,886
JBrowse link
G Nufip2 nuclear FMR1 interacting protein 2 decreases expression ISO tetrahydropalmatine results in decreased expression of NUFIP2 protein CTD PMID:20109541 NCBI chr10:65,168,145...65,200,210
Ensembl chr10:65,176,648...65,200,109
JBrowse link
G Nup155 nucleoporin 155 decreases expression ISO tetrahydropalmatine results in decreased expression of NUP155 protein CTD PMID:20109541 NCBI chr 2:57,206,665...57,258,242
Ensembl chr 2:57,206,613...57,258,295
JBrowse link
G Palld palladin, cytoskeletal associated protein decreases expression ISO tetrahydropalmatine results in decreased expression of PALLD protein CTD PMID:20109541 NCBI chr16:31,865,712...31,948,168 JBrowse link
G Pawr pro-apoptotic WT1 regulator decreases expression ISO tetrahydropalmatine results in decreased expression of PAWR protein CTD PMID:20109541 NCBI chr 7:51,273,764...51,353,700
Ensembl chr 7:51,273,771...51,353,068
JBrowse link
G Pds5a PDS5 cohesin associated factor A increases expression ISO tetrahydropalmatine results in increased expression of PDS5A protein CTD PMID:20109541 NCBI chr14:44,185,445...44,282,308
Ensembl chr14:44,185,446...44,280,079
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein increases expression ISO tetrahydropalmatine results in increased expression of PICALM protein CTD PMID:20109541 NCBI chr 1:154,377,229...154,458,966
Ensembl chr 1:154,377,247...154,458,425
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 decreases expression ISO tetrahydropalmatine results in decreased expression of PIN1 protein CTD PMID:20109541 NCBI chr 8:21,669,236...21,680,615
Ensembl chr 8:21,669,236...21,680,615
JBrowse link
G Ppil3 peptidylprolyl isomerase like 3 decreases expression ISO tetrahydropalmatine results in decreased expression of PPIL3 protein CTD PMID:20109541 NCBI chr 9:65,315,407...65,329,145
Ensembl chr 9:65,315,410...65,329,066
JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta decreases expression ISO tetrahydropalmatine results in decreased expression of PPP2CB protein CTD PMID:20109541 NCBI chr16:62,273,276...62,294,767
Ensembl chr16:62,273,276...62,294,769
JBrowse link
G Praf2 PRA1 domain family, member 2 increases expression ISO tetrahydropalmatine results in increased expression of PRAF2 protein CTD PMID:20109541 NCBI chr  X:15,618,324...15,620,992
Ensembl chr  X:15,618,991...15,620,841
JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha decreases expression ISO tetrahydropalmatine results in decreased expression of PRKAR1A protein CTD PMID:20109541 NCBI chr10:97,940,705...97,959,199
Ensembl chr10:97,940,705...97,957,336
JBrowse link
G Prkca protein kinase C, alpha decreases expression ISO tetrahydropalmatine results in decreased expression of PRKCA protein CTD PMID:20109541 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prpf4 pre-mRNA processing factor 4 decreases expression ISO tetrahydropalmatine results in decreased expression of PRPF4 protein CTD PMID:20109541 NCBI chr 5:78,267,248...78,281,172
Ensembl chr 5:78,267,248...78,281,172
JBrowse link
G Prpsap1 phosphoribosyl pyrophosphate synthetase-associated protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of PRPSAP1 protein CTD PMID:20109541 NCBI chr10:105,430,516...105,492,154
Ensembl chr10:105,430,520...105,452,228
JBrowse link
G Pym1 PYM homolog 1, exon junction complex associated factor decreases expression ISO tetrahydropalmatine results in decreased expression of PYM1 protein CTD PMID:20109541 NCBI chr 7:3,172,798...3,193,994
Ensembl chr 7:3,173,287...3,193,994
JBrowse link
G Rab3gap1 RAB3 GTPase activating protein catalytic subunit 1 decreases expression ISO tetrahydropalmatine results in decreased expression of RAB3GAP1 protein CTD PMID:20109541 NCBI chr13:44,578,208...44,649,876
Ensembl chr13:44,615,553...44,648,620
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases expression ISO tetrahydropalmatine results in increased expression of RAF1 protein CTD PMID:20109541 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Ranbp2 RAN binding protein 2 decreases expression ISO tetrahydropalmatine results in decreased expression of RANBP2 protein CTD PMID:20109541 NCBI chr20:28,027,054...28,076,664
NCBI chr20:28,365,538...28,375,676
Ensembl chr20:28,027,054...28,076,664
Ensembl chr20:28,027,054...28,076,664
JBrowse link
G Rbm39 RNA binding motif protein 39 decreases expression
increases expression
ISO tetrahydropalmatine results in decreased expression of RBM39 protein
tetrahydropalmatine results in increased expression of RBM39 protein
CTD PMID:20109541 NCBI chr 3:151,691,498...151,724,723
Ensembl chr 3:151,691,514...151,724,654
JBrowse link
G Reep5 receptor accessory protein 5 decreases expression ISO tetrahydropalmatine results in decreased expression of REEP5 protein CTD PMID:20109541 NCBI chr18:27,128,462...27,159,693
Ensembl chr18:27,128,464...27,159,693
JBrowse link
G Rfc4 replication factor C subunit 4 increases expression ISO tetrahydropalmatine results in increased expression of RFC4 protein CTD PMID:20109541 NCBI chr11:81,358,592...81,373,044
Ensembl chr11:81,358,592...81,373,043
JBrowse link
G Rhob ras homolog family member B decreases expression ISO tetrahydropalmatine results in decreased expression of RHOB protein CTD PMID:20109541 NCBI chr 6:33,689,127...33,691,301
Ensembl chr 6:33,689,127...33,691,301
JBrowse link
G Rmnd5a required for meiotic nuclear division 5 homolog A increases expression ISO tetrahydropalmatine results in increased expression of RMND5A protein CTD PMID:20109541 NCBI chr 4:99,249,159...99,305,805
Ensembl chr 4:99,253,633...99,305,812
JBrowse link
G Rnf40 ring finger protein 40 decreases expression ISO tetrahydropalmatine results in decreased expression of RNF40 protein CTD PMID:20109541 NCBI chr 1:199,037,472...199,052,823
Ensembl chr 1:199,037,544...199,052,172
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 decreases expression ISO tetrahydropalmatine results in decreased expression of ROCK2 protein CTD PMID:20109541 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G Rpa2 replication protein A2 decreases expression ISO tetrahydropalmatine results in decreased expression of RPA2 protein CTD PMID:20109541 NCBI chr 5:150,957,041...150,967,597
Ensembl chr 5:150,957,001...150,968,269
JBrowse link
G Rps28 ribosomal protein S28 decreases expression ISO tetrahydropalmatine results in decreased expression of RPS28 protein CTD PMID:20109541 NCBI chr 7:18,682,071...18,683,440
Ensembl chr 7:18,682,071...18,683,440
JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 increases expression ISO tetrahydropalmatine results in increased expression of RPS6KA3 protein CTD PMID:20109541 NCBI chr  X:37,469,736...37,576,055
Ensembl chr  X:37,469,937...37,575,624
JBrowse link
G Septin11 septin 11 decreases expression ISO tetrahydropalmatine results in decreased expression of SEPTIN11 protein CTD PMID:20109541 NCBI chr14:16,369,544...16,405,645
Ensembl chr14:16,369,544...16,452,998
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO tetrahydropalmatine inhibits the reaction [SLC22A1 protein results in increased uptake of Monocrotaline]; tetrahydropalmatine inhibits the reaction [SLC22A1 protein results in increased uptake of retrorsine] CTD PMID:23831208, PMID:24799337 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc25a10 solute carrier family 25 member 10 increases expression ISO tetrahydropalmatine results in increased expression of SLC25A10 protein CTD PMID:20109541 NCBI chr10:109,665,682...109,674,782
Ensembl chr10:109,665,682...109,673,143
JBrowse link
G Smarca5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 decreases expression ISO tetrahydropalmatine results in decreased expression of SMARCA5 protein CTD PMID:20109541 NCBI chr19:30,936,703...30,969,454
Ensembl chr19:30,936,703...30,969,454
JBrowse link
G Sms spermine synthase decreases expression ISO tetrahydropalmatine results in decreased expression of SMS protein CTD PMID:20109541 NCBI chr  X:40,363,646...40,415,110
Ensembl chr  X:40,363,646...40,415,109
JBrowse link
G Sncg synuclein, gamma decreases expression ISO tetrahydropalmatine results in decreased expression of SNCG protein CTD PMID:20109541 NCBI chr16:10,722,110...10,726,648
Ensembl chr16:10,722,106...10,726,707
JBrowse link
G Snrpe small nuclear ribonucleoprotein polypeptide E decreases expression ISO tetrahydropalmatine results in decreased expression of SNRPE protein CTD PMID:20109541 NCBI chr13:50,252,707...50,258,951
Ensembl chr 8:129,371,556...129,371,973
JBrowse link
G Snw1 SNW domain containing 1 decreases expression ISO tetrahydropalmatine results in decreased expression of SNW1 protein CTD PMID:20109541 NCBI chr 6:111,483,698...111,507,782
Ensembl chr 6:111,483,703...111,507,782
JBrowse link
G Snx1 sorting nexin 1 decreases expression ISO tetrahydropalmatine results in decreased expression of SNX1 protein CTD PMID:20109541 NCBI chr 8:71,745,687...71,786,182
Ensembl chr 8:71,745,896...71,784,551
JBrowse link
G Snx2 sorting nexin 2 decreases expression ISO tetrahydropalmatine results in decreased expression of SNX2 protein CTD PMID:20109541 NCBI chr18:48,132,386...48,173,974
Ensembl chr18:48,132,414...48,173,971
JBrowse link
G Spdl1 spindle apparatus coiled-coil protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of SPDL1 protein CTD PMID:20109541 NCBI chr10:19,628,070...19,652,914
Ensembl chr10:19,628,258...19,652,898
JBrowse link
G Sri sorcin decreases expression ISO tetrahydropalmatine results in decreased expression of SRI protein CTD PMID:20109541 NCBI chr 4:23,004,657...23,029,233
Ensembl chr 4:23,006,243...23,018,983
JBrowse link
G Srp19 signal recognition particle 19 decreases expression ISO tetrahydropalmatine results in decreased expression of SRP19 protein CTD PMID:20109541 NCBI chr18:27,114,822...27,121,062
Ensembl chr18:27,114,822...27,121,059
JBrowse link
G Srp68 signal recognition particle 68 decreases expression ISO tetrahydropalmatine results in decreased expression of SRP68 protein CTD PMID:20109541 NCBI chr10:105,123,324...105,150,080
Ensembl chr10:105,123,327...105,228,547
JBrowse link
G Srpra SRP receptor subunit alpha decreases expression ISO tetrahydropalmatine results in decreased expression of SRPRA protein CTD PMID:20109541 NCBI chr 8:36,410,683...36,416,766
Ensembl chr 8:36,410,683...36,416,296
JBrowse link
G Stat1 signal transducer and activator of transcription 1 increases expression ISO tetrahydropalmatine results in increased expression of STAT1 protein CTD PMID:20109541 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stxbp1 syntaxin binding protein 1 decreases expression ISO tetrahydropalmatine results in decreased expression of STXBP1 protein CTD PMID:20109541 NCBI chr 3:11,823,779...11,885,479
Ensembl chr 3:11,823,785...11,885,417
JBrowse link
G Swap70 switching B-cell complex subunit SWAP70 increases expression ISO tetrahydropalmatine results in increased expression of SWAP70 protein CTD PMID:20109541 NCBI chr 1:174,862,683...174,924,101
Ensembl chr 1:174,862,698...174,924,078
JBrowse link
G Syvn1 synoviolin 1 decreases expression ISO tetrahydropalmatine results in decreased expression of SYVN1 protein CTD PMID:20109541 NCBI chr 1:221,409,281...221,416,229
Ensembl chr 1:221,409,271...221,417,886
JBrowse link
G Tma7 translation machinery associated 7 homolog decreases expression ISO tetrahydropalmatine results in decreased expression of TMA7 protein CTD PMID:20109541 NCBI chr 8:117,815,725...117,820,422
Ensembl chr 8:117,815,725...117,820,413
JBrowse link
G Tmed4 transmembrane p24 trafficking protein 4 decreases expression ISO tetrahydropalmatine results in decreased expression of TMED4 protein CTD PMID:20109541 NCBI chr14:86,390,327...86,395,151
Ensembl chr14:86,390,338...86,395,135
JBrowse link
G Top1 DNA topoisomerase I increases expression ISO tetrahydropalmatine results in increased expression of TOP1 protein CTD PMID:20109541 NCBI chr 3:156,635,688...156,717,686
Ensembl chr 3:156,642,464...156,717,686
JBrowse link
G Tsnax translin-associated factor X decreases expression ISO tetrahydropalmatine results in decreased expression of TSNAX protein CTD PMID:20109541 NCBI chr19:57,771,539...57,785,567
Ensembl chr19:57,771,398...57,785,543
JBrowse link
G Tsr2 TSR2, ribosome maturation factor increases expression ISO tetrahydropalmatine results in increased expression of TSR2 protein CTD PMID:20109541 NCBI chr  X:20,141,406...20,146,082
Ensembl chr  X:20,144,432...20,232,639
JBrowse link
G Ttc37 tetratricopeptide repeat domain 37 decreases expression ISO tetrahydropalmatine results in decreased expression of TTC37 protein CTD PMID:20109541 NCBI chr 2:2,891,265...3,037,602
Ensembl chr 2:2,903,492...3,004,553
JBrowse link
G Uap1 UDP-N-acetylglucosamine pyrophosphorylase 1 increases expression ISO tetrahydropalmatine results in increased expression of UAP1 protein CTD PMID:20109541 NCBI chr13:88,463,532...88,497,901
Ensembl chr13:88,463,532...88,497,901
JBrowse link
G Vps45 vacuolar protein sorting 45 homolog increases expression ISO tetrahydropalmatine results in increased expression of VPS45 protein CTD PMID:20109541 NCBI chr 2:198,123,747...198,184,739
Ensembl chr 2:198,123,748...198,184,739
JBrowse link
G Wdhd1 WD repeat and HMG-box DNA binding protein 1 increases expression ISO tetrahydropalmatine results in increased expression of WDHD1 protein CTD PMID:20109541 NCBI chr15:24,021,674...24,056,073
Ensembl chr15:24,021,674...24,056,073
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            eukaryotic metabolite 18906
              plant metabolite 17359
                palmatine 159
                  tetrahydropalmatine 147
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organonitrogen heterocyclic compound 17460
                                    dibenzoquinolizine 359
                                      berberine alkaloid 359
                                        palmatine 159
                                          tetrahydropalmatine 147
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.