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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1H-imidazole
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Accession:CHEBI:16069 term browser browse the term
Definition:An imidazole tautomer which has the migrating hydrogen at position 1.
Synonyms:related_synonym: 1,3-diaza-2,4-cyclopentadiene;   1,3-diazole;   Formula=C3H4N2;   Glyoxaline;   Him;   IMD;   Imidazol;   InChI=1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5);   InChIKey=RAXXELZNTBOGNW-UHFFFAOYSA-N;   N,N'-1,2-ethenediylmethanimidamide;   N,N'-vinyleneformamidine;   SMILES=c1c[nH]cn1;   imidazole;   iminazole;   miazole;   pyrro[b]monazole
 alt_id: CHEBI:24772;   CHEBI:5872
 xref: Beilstein:103853;   CAS:288-32-4;   Gmelin:1417;   HMDB:HMDB0001525;   KEGG:C01589
 xref_mesh: MESH:C029899
 xref: PDBeChem:IMD;   PMID:9730817;   Patent:US3255200;   Reaxys:103853
 cyclic_relationship: is_conjugate_acid_of CHEBI:30366;   is_conjugate_base_of CHEBI:50059;   is_tautomer_of CHEBI:51802


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1H-imidazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 multiple interactions ISO imidazole promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein] CTD PMID:17196553 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Cat catalase decreases activity ISO imidazole analog results in decreased activity of CAT protein CTD PMID:23696008 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP imidazole results in increased expression of CYP2E1 protein CTD PMID:3337723 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 decreases activity ISO imidazole results in decreased activity of ENPP7 protein CTD PMID:12885774 NCBI chr10:108,095,131...108,099,483
Ensembl chr10:108,095,131...108,099,483
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP imidazole results in increased expression of GSTA2 mRNA CTD PMID:8951341 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression EXP imidazole results in increased expression of GSTA3 mRNA CTD PMID:8951341 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP imidazole results in increased expression of GSTA5 mRNA CTD PMID:8951341 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP imidazole results in increased expression of GSTM1 mRNA CTD PMID:8951341 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO imidazole results in increased expression of and results in increased secretion of IL1B protein CTD PMID:29953848 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression ISO imidazole results in increased expression of IL6 protein CTD PMID:29953848 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Sdr16c5 short chain dehydrogenase/reductase family 16C, member 5 decreases activity ISO imidazole results in decreased activity of SDR16C5 protein CTD PMID:18926804 NCBI chr 5:16,904,926...16,930,111
Ensembl chr 5:16,904,926...16,930,075
JBrowse link
G Tyr tyrosinase multiple interactions
increases expression
ISO Estradiol inhibits the reaction [imidazole results in increased expression of TYR protein]; Estriol inhibits the reaction [imidazole results in increased expression of TYR protein] CTD PMID:3127403 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      molecular entity 19808
        mancude ring 8123
          organic mancude parent 8123
            mancude organic heterocyclic parent 8123
              mancude organic heteromonocyclic parent 4636
                1H-imidazole 12
                  2-nitroimidazole 0
                  4-aminoimidazole 0
                  imidazolyl group + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic molecule 19514
                              organic cyclic compound 19311
                                organic heterocyclic compound 18425
                                  heteroarene 16469
                                    monocyclic heteroarene 13315
                                      azole 12482
                                        diazole 8135
                                          imidazoles 7663
                                            imidazole 12
                                              1H-imidazole 12
                                                2-nitroimidazole 0
                                                4-aminoimidazole 0
                                                imidazolyl group + 0
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