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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-nitropropane
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Accession:CHEBI:16037 term browser browse the term
Definition:A secondary nitroalkane that is propane in which a hydrogen at position 2 has been replaced by a nitro group. Mainly used as a solvent (b.p. 120degreeC).
Synonyms:related_synonym: Formula=C3H7NO2;   InChI=1S/C3H7NO2/c1-3(2)4(5)6/h3H,1-2H3;   InChIKey=FGLBSLMDCBOPQK-UHFFFAOYSA-N;   SMILES=CC(C)[N+]([O-])=O;   dimethylnitromethane;   i-C3H7NO2;   isonitropropane;   sec-nitropropane
 alt_id: CHEBI:11632;   CHEBI:1226;   CHEBI:19727;   CHEBI:44443
 xref: CAS:79-46-9;   KEGG:C02116
 xref_mesh: MESH:C016617
 xref: MetaCyc:CPD-244;   PDBeChem:NIS;   PMID:1934149;   PMID:21860502;   PMID:22319232;   PMID:25892624;   Reaxys:1740684;   UM-BBD_compID:c0555;   Wikipedia:2-Nitropropane


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2-nitropropane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression EXP 2-nitropropane results in increased expression of ABCB1B mRNA CTD PMID:17070881 NCBI chr 4:25,242,761...25,325,194 JBrowse link
G Acmsd aminocarboxymuconate semialdehyde decarboxylase decreases expression EXP 2-nitropropane results in decreased expression of ACMSD mRNA CTD PMID:17070881 NCBI chr13:39,200,486...39,244,337 JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 increases expression EXP 2-nitropropane results in increased expression of ACSL3 mRNA CTD PMID:17070881 NCBI chr 9:80,140,996...80,164,636 JBrowse link
G Aen apoptosis enhancing nuclease increases expression EXP 2-nitropropane results in increased expression of AEN mRNA CTD PMID:17070881 NCBI chr 1:132,815,094...132,824,522 JBrowse link
G Afp alpha-fetoprotein multiple interactions
increases expression
EXP diphenyldiselenide inhibits the reaction [2-nitropropane results in increased expression of AFP protein] CTD PMID:15804453 NCBI chr14:17,573,412...17,591,476 JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP 2-nitropropane results in increased expression of AKR7A3 mRNA CTD PMID:17070881 NCBI chr 5:151,590,968...151,601,394 JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP 2-nitropropane results in increased expression of ALDH1A1 mRNA CTD PMID:17070881 NCBI chr 1:218,000,470...218,152,962 JBrowse link
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 increases expression EXP 2-nitropropane results in increased expression of ALDH1A4 mRNA CTD PMID:17070881 NCBI chr 1:218,201,443...218,241,410 JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 affects response to substance
increases expression
multiple interactions
ISO APEX1 protein affects the susceptibility to 2-nitropropane
2-nitropropane results in increased expression of APEX1 mRNA; 2-nitropropane results in increased expression of APEX1 protein
APEX1 protein inhibits the reaction [2-nitropropane results in increased activity of CASP3 protein]; APEX1 protein inhibits the reaction [2-nitropropane results in increased expression of GADD45G mRNA]; APEX1 protein inhibits the reaction [2-nitropropane results in increased expression of TRP53 protein]
CTD PMID:19268524 NCBI chr15:24,144,595...24,146,785 JBrowse link
G Apoa2 apolipoprotein A2 decreases expression EXP 2-nitropropane results in decreased expression of APOA2 mRNA CTD PMID:17070881 NCBI chr13:83,644,460...83,646,358 JBrowse link
G Apoa4 apolipoprotein A4 decreases expression EXP 2-nitropropane results in decreased expression of APOA4 mRNA CTD PMID:17070881 NCBI chr 8:46,539,083...46,541,464 JBrowse link
G Apoc3 apolipoprotein C3 decreases expression EXP 2-nitropropane results in decreased expression of APOC3 mRNA CTD PMID:17070881 NCBI chr 8:46,531,478...46,533,658 JBrowse link
G Atp6v1d ATPase H+ transporting V1 subunit D increases expression EXP 2-nitropropane results in increased expression of ATP6V1D mRNA CTD PMID:17070881 NCBI chr 6:97,656,725...97,672,211 JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP 2-nitropropane results in increased expression of BAX mRNA CTD PMID:17070881 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression EXP 2-nitropropane results in increased expression of BTG2 mRNA CTD PMID:17070881 NCBI chr13:45,531,881...45,535,642 JBrowse link
G C7 complement C7 increases expression EXP 2-nitropropane results in increased expression of C7 mRNA CTD PMID:17070881 NCBI chr 2:54,088,116...54,165,102 JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO 2-nitropropane results in increased activity of CASP3 protein
APEX1 protein inhibits the reaction [2-nitropropane results in increased activity of CASP3 protein]
CTD PMID:19268524 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Cat catalase decreases activity
multiple interactions
EXP 2-nitropropane results in decreased activity of CAT protein
diphenyldiselenide inhibits the reaction [2-nitropropane results in decreased activity of CAT protein]; m-trifluoromethyl-diphenyl diselenide inhibits the reaction [2-nitropropane results in decreased activity of CAT protein]
CTD PMID:16445897 PMID:18818063 NCBI chr 3:89,842,393...89,874,577 JBrowse link
G Cblc Cbl proto-oncogene C increases expression EXP 2-nitropropane results in increased expression of CBLC mRNA CTD PMID:17070881 NCBI chr 1:79,439,975...79,456,755 JBrowse link
G Ccng1 cyclin G1 increases expression EXP 2-nitropropane results in increased expression of CCNG1 mRNA CTD PMID:17070881 NCBI chr10:25,176,231...25,182,604 JBrowse link
G Cd276 Cd276 molecule increases expression EXP 2-nitropropane results in increased expression of CD276 mRNA CTD PMID:17070881 NCBI chr 8:58,937,751...58,968,082 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP 2-nitropropane results in increased expression of CDKN1A mRNA CTD PMID:17070881 NCBI chr20:7,149,177...7,159,727 JBrowse link
G Cpq carboxypeptidase Q decreases expression EXP 2-nitropropane results in decreased expression of CPQ mRNA CTD PMID:17070881 NCBI chr 7:64,264,025...64,830,867 JBrowse link
G Cryab crystallin, alpha B increases expression EXP 2-nitropropane results in increased expression of CRYAB mRNA CTD PMID:17070881 NCBI chr 8:51,093,441...51,099,161 JBrowse link
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 increases expression EXP 2-nitropropane results in increased expression of CYP2C13 mRNA CTD PMID:17070881 NCBI chr 1:238,786,764...238,867,195 JBrowse link
G Cyp4f5 cytochrome P450, family 4, subfamily f, polypeptide 5 increases expression EXP 2-nitropropane results in increased expression of CYP4F5 mRNA CTD PMID:17070881 NCBI chr 7:11,544,040...11,558,982 JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 increases expression EXP 2-nitropropane results in increased expression of DDAH1 mRNA CTD PMID:17070881 NCBI chr 2:234,667,499...234,800,322 JBrowse link
G Epcam epithelial cell adhesion molecule increases expression EXP 2-nitropropane results in increased expression of EPCAM mRNA CTD PMID:17070881 NCBI chr 6:6,880,142...6,896,103 JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP 2-nitropropane results in increased expression of EPHX1 mRNA CTD PMID:17070881 NCBI chr13:92,714,315...92,744,124 JBrowse link
G Fas Fas cell surface death receptor increases expression EXP 2-nitropropane results in increased expression of FAS mRNA CTD PMID:17070881 NCBI chr 1:231,798,963...231,832,591 JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase decreases expression EXP 2-nitropropane results in decreased expression of FHIT mRNA CTD PMID:17070881 NCBI chr15:13,935,029...15,442,620 JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression
multiple interactions
ISO 2-nitropropane results in increased expression of GADD45G mRNA
APEX1 protein inhibits the reaction [2-nitropropane results in increased expression of GADD45G mRNA]
CTD PMID:19268524 NCBI chr17:13,376,842...13,378,587 JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 increases expression EXP 2-nitropropane results in increased expression of GRIA3 mRNA CTD PMID:17070881 NCBI chr  X:120,238,515...120,504,106 JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP 2-nitropropane results in increased expression of GSTM1 mRNA CTD PMID:17070881 NCBI chr 2:195,649,845...195,655,402 JBrowse link
G Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 decreases expression EXP 2-nitropropane results in decreased expression of HSD17B6 mRNA CTD PMID:17070881 NCBI chr 7:422,466...442,008 JBrowse link
G Il2ra interleukin 2 receptor subunit alpha increases expression EXP 2-nitropropane results in increased expression of IL2RA mRNA CTD PMID:17070881 NCBI chr17:66,849,974...66,898,665 JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP 2-nitropropane results in increased expression of MGMT mRNA CTD PMID:17070881 NCBI chr 1:191,710,980...191,937,760 JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator decreases expression EXP 2-nitropropane results in decreased expression of NUPR1 mRNA CTD PMID:17070881 NCBI chr 1:181,213,292...181,215,327 JBrowse link
G Olr37 olfactory receptor 37 decreases expression EXP 2-nitropropane results in decreased expression of OLR37 mRNA CTD PMID:17070881 NCBI chr 1:154,089,219...154,090,184 JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression EXP 2-nitropropane results in increased expression of PHLDA3 mRNA CTD PMID:17070881 NCBI chr13:47,193,250...47,196,335 JBrowse link
G Polb DNA polymerase beta multiple interactions ISO 2-nitropropane results in increased expression of and results in increased activity of POLB protein; POLB protein inhibits the reaction [2-nitropropane results in increased expression of TRP53 protein] CTD PMID:12189182 NCBI chr16:69,379,438...69,402,710 JBrowse link
G Rhobtb2 Rho-related BTB domain containing 2 increases expression EXP 2-nitropropane results in increased expression of RHOBTB2 mRNA CTD PMID:17070881 NCBI chr15:44,868,251...44,888,436 JBrowse link
G Serpina7 serpin family A member 7 increases expression EXP 2-nitropropane results in increased expression of SERPINA7 mRNA CTD PMID:17070881 NCBI chr  X:102,663,242...102,722,319 JBrowse link
G Slc16a10 solute carrier family 16 member 10 decreases expression EXP 2-nitropropane results in decreased expression of SLC16A10 mRNA CTD PMID:17070881 NCBI chr20:43,454,819...43,567,839 JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 decreases expression EXP 2-nitropropane results in decreased expression of SPINK1 mRNA CTD PMID:17070881 NCBI chr18:35,870,723...35,882,693 JBrowse link
G Sugct succinylCoA:glutarate-CoA transferase decreases expression EXP 2-nitropropane results in decreased expression of SUGCT mRNA CTD PMID:17070881 NCBI chr17:47,376,392...48,234,362 JBrowse link
G Sulf2 sulfatase 2 increases expression EXP 2-nitropropane results in increased expression of SULF2 mRNA CTD PMID:17070881 NCBI chr 3:154,822,079...154,904,566 JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression EXP 2-nitropropane results in decreased expression of SULT2A1 mRNA CTD PMID:17070881 NCBI chr 1:75,451,178...75,508,142 JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO APEX1 protein inhibits the reaction [2-nitropropane results in increased expression of TRP53 protein]; POLB protein inhibits the reaction [2-nitropropane results in increased expression of TRP53 protein] CTD PMID:12189182 PMID:16720738 PMID:19268524 NCBI chr10:54,300,070...54,311,525 JBrowse link
G Zmat3 zinc finger, matrin type 3 increases expression EXP 2-nitropropane results in increased expression of ZMAT3 mRNA CTD PMID:17070881 NCBI chr 2:115,106,050...115,136,863 JBrowse link

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  CHEBI ontology 19762
    role 19708
      biological role 19708
        xenobiotic 18395
          2-nitropropane 50
Path 2
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  CHEBI ontology 19762
    subatomic particle 19760
      composite particle 19760
        hadron 19760
          baryon 19760
            nucleon 19760
              atomic nucleus 19760
                atom 19760
                  main group element atom 19651
                    p-block element atom 19651
                      pnictogen 18723
                        nitrogen atom 18634
                          nitrogen molecular entity 18634
                            nitro compound 10716
                              C-nitro compound 10440
                                nitrohydrocarbon 1565
                                  nitroalkane 50
                                    secondary nitroalkane 50
                                      2-nitropropane 50
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