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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:androsterone
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Accession:CHEBI:16032 term browser browse the term
Definition:An androstanoid that is 5alpha-androstane having a hydroxy substituent at the 3alpha-position and an oxo group at the 17-position. It is a metabolite of dehydroepiandrosterone .
Synonyms:related_synonym: (3alpha,5alpha)-3-hydroxyandrostan-17-one;   3-epihydroxyetioallocholan-17-one;   3alpha-hydroxy-5alpha-androstan-17-one;   3alpha-hydroxyetioallocholan-17-one;   5alpha-androstane-3alpha-ol-17-one;   5alpha-androsterone;   Androkinine;   Androtine;   Formula=C19H30O2;   InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1;   InChIKey=QGXBDMJGAMFCBF-HLUDHZFRSA-N;   SMILES=[H][C@@]12CC[C@@]3([H])[C@]4([H])CCC(=O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CC[C@@H](O)C2;   cis-androsterone
 alt_id: CHEBI:13832;   CHEBI:20235;   CHEBI:2714
 xref: Beilstein:2217626;   CAS:53-41-8;   Gmelin:700649;   HMDB:HMDB0000031;   KEGG:C00523;   LIPID_MAPS_instance:LMST02020001
 xref_mesh: MESH:D000738
 xref: PMID:10438974;   PMID:19493957;   PMID:24705905;   Reaxys:2217626;   Wikipedia:Androsterone


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androsterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor affects binding EXP Androsterone binds to AR protein CTD PMID:14565775 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 affects chemical synthesis ISO CYP17A1 protein affects the chemical synthesis of Androsterone CTD PMID:14522586 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 increases reduction ISO DHRS11 protein results in increased reduction of Androsterone CTD PMID:30926317 NCBI chr10:72,144,042...72,153,496
Ensembl chr10:72,144,042...72,153,375
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity EXP Androsterone results in decreased activity of G6PD protein CTD PMID:7752092 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 increases metabolic processing ISO HSD17B12 protein results in increased metabolism of Androsterone CTD PMID:17641292 NCBI chr 3:82,924,699...83,048,465
Ensembl chr 3:82,924,687...83,048,435
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Androsterone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO Androsterone inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Diethylstilbestrol] CTD PMID:23126256 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein SNP results in increased glucuronidation of Androsterone analog CTD PMID:15708967 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b UDP glycosyltransferase 2 family, polypeptide B increases glucuronidation EXP UGT2B protein results in increased glucuronidation of Androsterone CTD PMID:2429951 Ensembl chr14:22,375,955...22,534,720 JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases metabolic processing ISO UGT2B17 protein results in increased metabolism of Androsterone CTD PMID:8798464 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation
decreases activity
multiple interactions
ISO UGT2B7 protein results in increased glucuronidation of Androsterone
Androsterone results in decreased activity of UGT2B7 protein
Androsterone inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Diethylstilbestrol]
CTD PMID:11186130, PMID:23126256, PMID:26875642 NCBI chr14:22,597,103...22,619,968 JBrowse link
androsterone 3-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kl Klotho multiple interactions ISO androsterone glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] CTD PMID:14701853 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        molecular messenger 18279
          hormone 18031
            sex hormone 17913
              androgen 3940
                androsterone 12
                  androsterone 3-glucosiduronic acid 1
                  androsterone sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      ketone 16173
                                        oxo steroid 9283
                                          17-oxo steroid 257
                                            androsterone 12
                                              androsterone 3-glucosiduronic acid 1
                                              androsterone sulfate 0
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