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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:indole-3-acetamide
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Accession:CHEBI:16031 term browser browse the term
Definition:A member of the class of indoles that is acetamide substituted by a 1H-indol-3-yl group at position 2. It is an intermediate in the production of plant hormone indole acetic acid (IAA).
Synonyms:exact_synonym: 2-(1H-indol-3-yl)acetamide
 related_synonym: 1H-indole-3-acetamide;   3-indoleacetamide;   Formula=C10H10N2O;   InChI=1S/C10H10N2O/c11-10(13)5-7-6-12-9-4-2-1-3-8(7)9/h1-4,6,12H,5H2,(H2,11,13);   InChIKey=ZOAMBXDOGPRZLP-UHFFFAOYSA-N;   SMILES=NC(=O)Cc1c[nH]c2ccccc12;   indoleacetamide
 alt_id: CHEBI:14446;   CHEBI:24800;   CHEBI:46118;   CHEBI:5904
 xref: Beilstein:143368;   CAS:879-37-8;   HMDB:HMDB0029739;   KEGG:C02693;   KNApSAcK:C00000108
 xref_mesh: MESH:C015950
 xref: MetaCyc:CPD-237;   PDBeChem:TSR;   PMID:22079545;   PMID:22210218;   PMID:22447967;   PMID:23306880;   PMID:23521653;   PMID:24350783;   Reaxys:143368



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indole-3-acetamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions
ISO indoleacetamide results in increased expression of ABCB1 mRNA
indoleacetamide promotes the reaction [NR1I2 protein binds to ABCB1 promoter]; NR1I2 protein promotes the reaction [indoleacetamide results in increased expression of ABCB1 mRNA]
CTD PMID:33002526 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO indoleacetamide results in increased expression of CYP3A4 mRNA
NR1I2 protein promotes the reaction [indoleacetamide results in increased expression of CYP3A4 mRNA]
CTD PMID:33002526 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO indoleacetamide binds to and results in increased activity of NR1I2 protein; indoleacetamide promotes the reaction [NR1I2 protein binds to ABCB1 promoter]; NR1I2 protein promotes the reaction [indoleacetamide results in increased expression of ABCB1 mRNA]; NR1I2 protein promotes the reaction [indoleacetamide results in increased expression of CYP3A4 mRNA] CTD PMID:33002526 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19751
    role 19724
      biological role 19722
        biochemical role 19443
          metabolite 19430
            eukaryotic metabolite 19227
              plant metabolite 17860
                indole-3-acetamide 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19751
    subatomic particle 19749
      composite particle 19749
        hadron 19749
          baryon 19749
            nucleon 19749
              atomic nucleus 19749
                atom 19749
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19644
                        carbon atom 19640
                          organic molecular entity 19640
                            organic group 18846
                              organic divalent group 18832
                                organodiyl group 18832
                                  carbonyl group 18799
                                    carbonyl compound 18799
                                      carboxylic acid 18515
                                        carboacyl group 17655
                                          univalent carboacyl group 17655
                                            carbamoyl group 17498
                                              carboxamide 17498
                                                acetamides 14633
                                                  acetamide 8767
                                                    indole-3-acetamide 3
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