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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:indole-3-acetamide
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Accession:CHEBI:16031 term browser browse the term
Definition:A member of the class of indoles that is acetamide substituted by a 1H-indol-3-yl group at position 2. It is an intermediate in the production of plant hormone indole acetic acid (IAA).
Synonyms:exact_synonym: 2-(1H-indol-3-yl)acetamide
 related_synonym: 1H-indole-3-acetamide;   3-indoleacetamide;   Formula=C10H10N2O;   InChI=1S/C10H10N2O/c11-10(13)5-7-6-12-9-4-2-1-3-8(7)9/h1-4,6,12H,5H2,(H2,11,13);   InChIKey=ZOAMBXDOGPRZLP-UHFFFAOYSA-N;   SMILES=NC(=O)Cc1c[nH]c2ccccc12;   indoleacetamide
 alt_id: CHEBI:14446;   CHEBI:24800;   CHEBI:46118;   CHEBI:5904
 xref: CAS:879-37-8;   HMDB:HMDB0029739;   KEGG:C02693;   KNApSAcK:C00000108
 xref_mesh: MESH:C015950
 xref: MetaCyc:CPD-237;   PDBeChem:TSR;   PMID:22079545;   PMID:22210218;   PMID:22447967;   PMID:23306880;   PMID:23521653;   PMID:24350783;   Reaxys:143368


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indole-3-acetamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions		 ISO indoleacetamide results in increased expression of ABCB1 mRNA
indoleacetamide promotes the reaction [NR1I2 protein binds to ABCB1 promoter]; NR1I2 protein promotes the reaction [indoleacetamide results in increased expression of ABCB1 mRNA]		 CTD PMID:33002526 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions		 ISO indoleacetamide results in increased expression of CYP3A4 mRNA
NR1I2 protein promotes the reaction [indoleacetamide results in increased expression of CYP3A4 mRNA]		 CTD PMID:33002526 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO indoleacetamide binds to and results in increased activity of NR1I2 protein; indoleacetamide promotes the reaction [NR1I2 protein binds to ABCB1 promoter]; NR1I2 protein promotes the reaction [indoleacetamide results in increased expression of ABCB1 mRNA]; NR1I2 protein promotes the reaction [indoleacetamide results in increased expression of CYP3A4 mRNA] CTD PMID:33002526 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      biological role 19867
        biochemical role 19574
          metabolite 19561
            eukaryotic metabolite 19385
              plant metabolite 18006
                indole-3-acetamide 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            heteroorganic entity 19532
                              organochalcogen compound 19293
                                organooxygen compound 19209
                                  carbon oxoacid 18678
                                    carboxylic acid 18675
                                      carboacyl group 17725
                                        univalent carboacyl group 17725
                                          carbamoyl group 17577
                                            carboxamide 17577
                                              acetamides 14652
                                                acetamide 8771
                                                  indole-3-acetamide 3
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