Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   


The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

go back to main search page
Accession:CHEBI:160246 term browser browse the term
Definition:A pyrazolone that is 1,2-dihydro-3H-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic properties.
Synonyms:related_synonym: (Dimethylamino)phenazone;   1,5-Dimethyl-4-dimethylamino-2-phenyl-3-pyrazolone;   1-Phenyl-2,3-dimethyl-4-dimethylaminopyrazol-5-one;   3-Keto-1,5-dimethyl-4-dimethylamino-2-phenyl-2,3-dihydropyrazole;   4-(Dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one;   4-(Dimethylamino)antipyrine;   4-Dimethylamino-1-phenyl-2,3-dimethylpyrazolone;   4-Dimethylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one;   4-Dimethylaminoantipyrine;   4-Dimethylaminophenazone;   Aminofenazone;   Aminophenazon;   Aminopyrine;   Dimethylaminoantipyrine;   Dimethylaminoazophene;   Dimethylaminophenazon;   Dimethylaminophenazone;   Dimethylaminophenyldimethylpyrazolone;   Dipyrine;   Formula=C13H17N3O;   InChI=1S/C13H17N3O/c1-10-12(14(2)3)13(17)16(15(10)4)11-8-6-5-7-9-11/h5-9H,1-4H3;   InChIKey=RMMXTBMQSGEXHJ-UHFFFAOYSA-N;   SMILES=CN(C)c1c(C)n(C)n(-c2ccccc2)c1=O;   aminofenazona;   aminophenazonum
 xref: Beilstein:222626;   CAS:58-15-1;   DrugBank:DB01424;   Drug_Central:171;   Gmelin:103164;   HMDB:HMDB0015493;   KEGG:C07539;   KEGG:D00556;   LINCS:LSM-20000
 xref_mesh: MESH:D000632
 xref: PMID:23603897;   PMID:23727364;   PMID:24428683;   Reaxys:222626;   Wikipedia:Aminophenazone

show annotations for term's descendants           Sort by:
aminophenazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions
decreases methylation
ISO Amoxicillin inhibits the reaction [CYP2C8 protein results in decreased methylation of Aminopyrine]; Piperacillin inhibits the reaction [CYP2C8 protein results in decreased methylation of Aminopyrine] CTD PMID:26763401
G Il1b interleukin 1 beta increases expression ISO Aminopyrine results in increased expression of IL1B mRNA CTD PMID:24747151 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO Aminopyrine analog results in decreased activity of PTGS1 protein; Aminopyrine results in decreased activity of PTGS1 protein CTD PMID:16141368 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      biological role 20008
        xenobiotic 18633
          aminophenazone 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic molecule 19819
                              organic cyclic compound 19581
                                organic heterocyclic compound 18804
                                  heteroarene 16601
                                    monocyclic heteroarene 13600
                                      azole 12823
                                        diazole 8611
                                          pyrazoles 2299
                                            pyrazolone 78
                                              aminophenazone 3
paths to the root