Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   


The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

go back to main search page
Accession:CHEBI:160246 term browser browse the term
Definition:A pyrazolone that is 1,2-dihydro-3H-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic properties.
Synonyms:related_synonym: (Dimethylamino)phenazone;   1,5-Dimethyl-4-dimethylamino-2-phenyl-3-pyrazolone;   1-Phenyl-2,3-dimethyl-4-dimethylaminopyrazol-5-one;   3-Keto-1,5-dimethyl-4-dimethylamino-2-phenyl-2,3-dihydropyrazole;   4-(Dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one;   4-(Dimethylamino)antipyrine;   4-Dimethylamino-1-phenyl-2,3-dimethylpyrazolone;   4-Dimethylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one;   4-Dimethylaminoantipyrine;   4-Dimethylaminophenazone;   Aminofenazone;   Aminophenazon;   Aminopyrine;   Dimethylaminoantipyrine;   Dimethylaminoazophene;   Dimethylaminophenazon;   Dimethylaminophenazone;   Dimethylaminophenyldimethylpyrazolone;   Dipyrine;   Formula=C13H17N3O;   InChI=1S/C13H17N3O/c1-10-12(14(2)3)13(17)16(15(10)4)11-8-6-5-7-9-11/h5-9H,1-4H3;   InChIKey=RMMXTBMQSGEXHJ-UHFFFAOYSA-N;   SMILES=CN(C)c1c(C)n(C)n(-c2ccccc2)c1=O;   aminofenazona;   aminophenazonum
 xref: Beilstein:222626;   CAS:58-15-1;   DrugBank:DB01424;   Drug_Central:171;   Gmelin:103164;   HMDB:HMDB0015493;   KEGG:C07539;   KEGG:D00556;   LINCS:LSM-20000
 xref_mesh: MESH:D000632
 xref: PMID:23603897;   PMID:23727364;   PMID:24428683;   Reaxys:222626;   Wikipedia:Aminophenazone

show annotations for term's descendants           Sort by:
aminophenazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions
decreases methylation
ISO Amoxicillin inhibits the reaction [CYP2C8 protein results in decreased methylation of Aminopyrine]; Piperacillin inhibits the reaction [CYP2C8 protein results in decreased methylation of Aminopyrine] CTD PMID:26763401 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Il1b interleukin 1 beta increases expression ISO Aminopyrine results in increased expression of IL1B mRNA CTD PMID:24747151 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO Aminopyrine analog results in decreased activity of PTGS1 protein; Aminopyrine results in decreased activity of PTGS1 protein CTD PMID:16141368 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      biological role 19716
        xenobiotic 18392
          aminophenazone 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic molecule 19497
                              organic cyclic compound 19321
                                organic heterocyclic compound 18512
                                  heteroarene 16520
                                    monocyclic heteroarene 13364
                                      azole 12538
                                        diazole 8254
                                          pyrazoles 1555
                                            pyrazolone 77
                                              aminophenazone 3
paths to the root