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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:aminophenazone
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Accession:CHEBI:160246 term browser browse the term
Definition:A pyrazolone that is 1,2-dihydro-3H-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic properties.
Synonyms:related_synonym: (Dimethylamino)phenazone;   1,5-Dimethyl-4-dimethylamino-2-phenyl-3-pyrazolone;   1-Phenyl-2,3-dimethyl-4-dimethylaminopyrazol-5-one;   3-Keto-1,5-dimethyl-4-dimethylamino-2-phenyl-2,3-dihydropyrazole;   4-(Dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one;   4-(Dimethylamino)antipyrine;   4-Dimethylamino-1-phenyl-2,3-dimethylpyrazolone;   4-Dimethylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one;   4-Dimethylaminoantipyrine;   4-Dimethylaminophenazone;   Aminofenazone;   Aminophenazon;   Aminopyrine;   Dimethylaminoantipyrine;   Dimethylaminoazophene;   Dimethylaminophenazon;   Dimethylaminophenazone;   Dimethylaminophenyldimethylpyrazolone;   Dipyrine;   Formula=C13H17N3O;   InChI=1S/C13H17N3O/c1-10-12(14(2)3)13(17)16(15(10)4)11-8-6-5-7-9-11/h5-9H,1-4H3;   InChIKey=RMMXTBMQSGEXHJ-UHFFFAOYSA-N;   SMILES=CN(C)c1c(C)n(C)n(-c2ccccc2)c1=O;   aminofenazona;   aminophenazonum
 xref: Beilstein:222626;   CAS:58-15-1;   DrugBank:DB01424;   Drug_Central:171;   Gmelin:103164;   HMDB:HMDB0015493;   KEGG:C07539;   KEGG:D00556;   LINCS:LSM-20000
 xref_mesh: MESH:D000632
 xref: PMID:23603897;   PMID:23727364;   PMID:24428683;   Reaxys:222626;   Wikipedia:Aminophenazone



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Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions
decreases methylation
ISO Amoxicillin inhibits the reaction [CYP2C8 protein results in decreased methylation of Aminopyrine]; Piperacillin inhibits the reaction [CYP2C8 protein results in decreased methylation of Aminopyrine] CTD PMID:26763401
G Il1b interleukin 1 beta increases expression ISO Aminopyrine results in increased expression of IL1B mRNA CTD PMID:24747151 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO Aminopyrine analog results in decreased activity of PTGS1 protein; Aminopyrine results in decreased activity of PTGS1 protein CTD PMID:16141368 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link

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  CHEBI ontology 19918
    role 19894
      biological role 19892
        xenobiotic 18778
          aminophenazone 3
Path 2
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  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic molecule 19758
                              organic cyclic compound 19565
                                organic heterocyclic compound 18906
                                  heteroarene 17172
                                    monocyclic heteroarene 14893
                                      azole 14396
                                        diazole 10488
                                          pyrazoles 2320
                                            pyrazolone 86
                                              aminophenazone 3
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