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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lycopene
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Accession:CHEBI:15948 term browser browse the term
Definition:An acyclic carotene commonly obtained from tomatoes and other red fruits.
Synonyms:exact_synonym: psi,psi-carotene
 related_synonym: (6E,8E,10E,12E,14E,16E,18E,20E,22E,24E,26E)-2,6,10,14,19,23,27,31-octamethyldotriaconta-2,6,8,10,12,14,16,18,20,22,24,26,30-tridecaene;   Formula=C40H56;   InChI=1S/C40H56/c1-33(2)19-13-23-37(7)27-17-31-39(9)29-15-25-35(5)21-11-12-22-36(6)26-16-30-40(10)32-18-28-38(8)24-14-20-34(3)4/h11-12,15-22,25-32H,13-14,23-24H2,1-10H3/b12-11+,25-15+,26-16+,31-17+,32-18+,35-21+,36-22+,37-27+,38-28+,39-29+,40-30+;   InChIKey=OAIJSZIZWZSQBC-GYZMGTAESA-N;   SMILES=CC(C)=CCC\\C(C)=C\\C=C\\C(C)=C\\C=C\\C(C)=C\\C=C\\C=C(C)\\C=C\\C=C(C)\\C=C\\C=C(/C)CCC=C(C)C;   all-trans-lycopene
 alt_id: CHEBI:14541;   CHEBI:26367;   CHEBI:43789;   CHEBI:6596
 xref: Beilstein:1730097;   CAS:502-65-8;   COMe:MOL000048;   Drug_Central:4617;   HMDB:HMDB0003000;   KEGG:C05432;   KNApSAcK:C00000911;   LIPID_MAPS_instance:LMPR01070257
 xref_mesh: MESH:C015329
 xref: MetaCyc:CPD1F-114;   PDBeChem:LYC;   PMID:10443333;   PMID:10493308;   PMID:10620348;   PMID:10720168;   PMID:10837319;   PMID:11117277;   PMID:11137891;   PMID:12239422;   PMID:12726756;   PMID:12792623;   PMID:12910307;   PMID:13129444;   PMID:15054415;   PMID:15065899;   PMID:15341191;   PMID:1550343;   PMID:15830922;   PMID:16194683;   PMID:16549453;   PMID:24397737;   PMID:7616301;   PMID:9100211;   Reaxys:1730097;   Wikipedia:Lycopene



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lycopene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP Lycopene inhibits the reaction [manganese chloride results in increased activity of ACHE protein]; Lycopene inhibits the reaction [Sodium Glutamate results in increased activity of ACHE protein] CTD PMID:22192907 PMID:26900785 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Add1 adducin 1 decreases expression ISO lycopene results in decreased expression of ADD1 mRNA CTD PMID:16886892 NCBI chr14:76,108,643...76,167,267
Ensembl chr14:76,108,654...76,167,182
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO lycopene inhibits the reaction [HMGB1 protein results in increased expression of AGER protein]; lycopene inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein] CTD PMID:22429818 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Ahr aryl hydrocarbon receptor decreases expression ISO lycopene results in decreased expression of AHR mRNA CTD PMID:16886892 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO lycopene inhibits the reaction [Galactose results in increased expression of AIF1 protein] CTD PMID:28974442 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO lycopene results in decreased phosphorylation of AKT1 protein CTD PMID:17337101 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alad aminolevulinate dehydratase multiple interactions ISO
EXP
lycopene inhibits the reaction [Zearalenone results in decreased activity of ALAD protein]
lycopene inhibits the reaction [Mercuric Chloride results in decreased activity of ALAD protein]
CTD PMID:17516994 PMID:25682699 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G Andpro androgen regulated protein decreases expression EXP lycopene results in decreased expression of ANDPRO mRNA CTD PMID:15084515 NCBI chr 3:136,718,601...136,725,131
Ensembl chr 3:136,718,602...136,724,966
JBrowse link
G Ar androgen receptor decreases expression ISO lycopene results in decreased expression of AR mRNA CTD PMID:16886892 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP Lycopene inhibits the reaction [Oxaliplatin results in increased expression of ATF6 mRNA] CTD PMID:32544411 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Atg10 autophagy related 10 multiple interactions ISO Lycopene inhibits the reaction [Atrazine results in decreased expression of ATG10 mRNA] CTD PMID:30360616 NCBI chr 2:22,109,304...22,398,313
Ensembl chr 2:22,108,426...22,398,233
JBrowse link
G Atg13 autophagy related 13 multiple interactions ISO Lycopene inhibits the reaction [Atrazine results in increased expression of ATG13 mRNA] CTD PMID:30360616 NCBI chr 3:77,647,069...77,681,028
Ensembl chr 3:77,645,790...77,681,043
JBrowse link
G Atg14 autophagy related 14 multiple interactions ISO Lycopene inhibits the reaction [Atrazine results in increased expression of ATG14 mRNA] CTD PMID:30360616 NCBI chr15:20,795,750...20,827,113
Ensembl chr15:20,795,750...20,827,113
JBrowse link
G Atg16l1 autophagy related 16-like 1 multiple interactions ISO Lycopene inhibits the reaction [Atrazine results in decreased expression of ATG16L1 mRNA] CTD PMID:30360616 NCBI chr 9:88,420,737...88,457,530
Ensembl chr 9:88,422,038...88,457,529
JBrowse link
G Atg16l2 autophagy related 16-like 2 multiple interactions ISO Lycopene inhibits the reaction [Atrazine results in increased expression of ATG16L2 mRNA] CTD PMID:30360616 NCBI chr 1:155,687,386...155,703,419
Ensembl chr 1:155,684,564...155,703,420
JBrowse link
G Atg2b autophagy related 2B multiple interactions ISO Lycopene inhibits the reaction [Atrazine results in increased expression of ATG2B mRNA] CTD PMID:30360616 NCBI chr 6:124,522,283...124,592,412
Ensembl chr 6:124,525,523...124,592,015
JBrowse link
G Atg3 autophagy related 3 multiple interactions ISO Lycopene inhibits the reaction [Atrazine results in decreased expression of ATG3 mRNA] CTD PMID:30360616 NCBI chr11:55,624,928...55,653,212
Ensembl chr11:55,624,917...55,653,224
JBrowse link
G Atg4a autophagy related 4A, cysteine peptidase multiple interactions ISO Lycopene inhibits the reaction [Atrazine results in decreased expression of ATG4A mRNA] CTD PMID:30360616 NCBI chr  X:104,665,345...104,765,271 JBrowse link
G Atg4b autophagy related 4B, cysteine peptidase multiple interactions ISO Lycopene inhibits the reaction [Atrazine results in increased expression of ATG4B mRNA] CTD PMID:30360616 NCBI chr 9:94,282,417...94,314,109
Ensembl chr 9:94,282,509...94,314,103
JBrowse link
G Atg4c autophagy related 4C, cysteine peptidase multiple interactions ISO Lycopene inhibits the reaction [Atrazine results in decreased expression of ATG4C mRNA] CTD PMID:30360616 NCBI chr 5:113,867,218...113,935,534
Ensembl chr 5:113,867,092...113,934,830
JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO Lycopene inhibits the reaction [Atrazine results in decreased expression of ATG5 mRNA] CTD PMID:30360616 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Atg7 autophagy related 7 multiple interactions ISO Lycopene inhibits the reaction [Atrazine results in increased expression of ATG7 mRNA] CTD PMID:30360616 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
JBrowse link
G Atg9a autophagy related 9A multiple interactions ISO Lycopene inhibits the reaction [Atrazine results in increased expression of ATG9A mRNA] CTD PMID:30360616 NCBI chr 9:76,677,403...76,688,035
Ensembl chr 9:76,677,404...76,687,986
JBrowse link
G Atg9b autophagy related 9B multiple interactions ISO Lycopene inhibits the reaction [Atrazine results in increased expression of ATG9B mRNA] CTD PMID:30360616 NCBI chr 4:10,784,934...10,793,832
Ensembl chr 4:10,786,114...10,793,651
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 multiple interactions ISO Lycopene inhibits the reaction [Atrazine affects the expression of ATP1A1 mRNA]; Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP1A1 mRNA]; Lycopene inhibits the reaction [Atrazine results in increased expression of ATP1A1 mRNA] CTD PMID:26476475 PMID:27112537 NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837
JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 multiple interactions ISO Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP1A2 mRNA] CTD PMID:27112537 NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544
JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 multiple interactions ISO lycopene inhibits the reaction [Atrazine results in decreased expression of ATP1A3 mRNA] CTD PMID:26476475 NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918
JBrowse link
G Atp1a4 ATPase Na+/K+ transporting subunit alpha 4 multiple interactions ISO Lycopene inhibits the reaction [Atrazine affects the expression of ATP1A4 mRNA] CTD PMID:26476475 PMID:27112537 NCBI chr13:84,683,766...84,719,790
Ensembl chr13:84,683,768...84,719,687
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 multiple interactions ISO Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP1B1 mRNA] CTD PMID:27112537 NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459
JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 multiple interactions ISO Lycopene inhibits the reaction [Atrazine affects the expression of ATP1B2 mRNA] CTD PMID:26476475 PMID:27112537 NCBI chr10:54,318,698...54,324,933
Ensembl chr10:54,318,701...54,324,933
JBrowse link
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 multiple interactions ISO lycopene inhibits the reaction [Atrazine affects the expression of ATP1B3 mRNA] CTD PMID:26476475 NCBI chr 8:96,910,265...96,941,592
Ensembl chr 8:96,910,309...96,941,598
JBrowse link
G Atp1b4 ATPase Na+/K+ transporting family member beta 4 multiple interactions ISO lycopene inhibits the reaction [Atrazine results in increased expression of ATP1B4 mRNA] CTD PMID:26476475 NCBI chr  X:117,087,284...117,108,023
Ensembl chr  X:117,057,423...117,108,020
JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 multiple interactions ISO Lycopene inhibits the reaction [Atrazine affects the expression of ATP2A1 mRNA] CTD PMID:27112537 NCBI chr 1:181,026,606...181,044,859 JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions ISO Lycopene inhibits the reaction [Atrazine affects the expression of ATP2A2 mRNA] CTD PMID:27112537 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 multiple interactions ISO Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP2A3 mRNA] CTD PMID:26476475 PMID:27112537 NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748
JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 multiple interactions ISO Lycopene inhibits the reaction [Atrazine affects the expression of ATP2B1 mRNA]; Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP2B1 mRNA] CTD PMID:26476475 PMID:27112537 NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295
JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 multiple interactions ISO Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP2B2 mRNA] CTD PMID:26476475 PMID:27112537 NCBI chr 4:146,896,332...147,140,665
Ensembl chr 4:146,896,332...147,140,665
JBrowse link
G Atp2b3 ATPase plasma membrane Ca2+ transporting 3 multiple interactions ISO Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP2B3 mRNA] CTD PMID:26476475 PMID:27112537 NCBI chr  X:151,216,483...151,289,069
Ensembl chr  X:151,216,507...151,286,775
JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 multiple interactions ISO Lycopene inhibits the reaction [Atrazine affects the expression of ATP2B4 mRNA] CTD PMID:26476475 PMID:27112537 NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246
JBrowse link
G Atp2c1 ATPase secretory pathway Ca2+ transporting 1 multiple interactions ISO Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP2C1 mRNA] CTD PMID:26476475 PMID:27112537 NCBI chr 8:106,034,777...106,155,854
Ensembl chr 8:106,034,636...106,156,006
JBrowse link
G Atp2c2 ATPase secretory pathway Ca2+ transporting 2 multiple interactions ISO Lycopene inhibits the reaction [Atrazine affects the expression of ATP2C2 mRNA]; Lycopene inhibits the reaction [Atrazine results in decreased expression of ATP2C2 mRNA] CTD PMID:26476475 PMID:27112537 NCBI chr19:47,754,120...47,811,369
Ensembl chr19:47,754,120...47,811,368
JBrowse link
G Bach1 BTB domain and CNC homolog 1 increases expression ISO lycopene results in increased expression of BACH1 mRNA CTD PMID:16886892 NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447
JBrowse link
G Bap1 Brca1 associated protein 1 increases expression ISO lycopene results in increased expression of BAP1 mRNA CTD PMID:16886892 NCBI chr16:6,446,709...6,455,535
Ensembl chr16:6,446,709...6,455,535
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP
lycopene inhibits the reaction [Sodium Fluoride results in increased expression of BAX mRNA]
Lycopene inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX mRNA]; Lycopene inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein]; Lycopene inhibits the reaction [Sodium Fluoride results in increased expression of BAX mRNA]; Lycopene inhibits the reaction [Sodium Glutamate results in increased expression of BAX mRNA]
CTD PMID:26900785 PMID:27871895 PMID:31568845 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP Lycopene inhibits the reaction [Sodium Glutamate results in increased activity of BCHE protein] CTD PMID:26900785 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
EXP
ISO
[S-allylcysteine co-treated with Lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]; Lycopene inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]; Lycopene inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 mRNA]; Lycopene inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein]; Lycopene inhibits the reaction [Sodium Fluoride results in decreased expression of BCL2 mRNA]; Lycopene inhibits the reaction [Sodium Glutamate results in decreased expression of BCL2 mRNA]
Lycopene results in increased expression of BCL2 mRNA
lycopene inhibits the reaction [Sodium Fluoride results in decreased expression of BCL2 mRNA]
CTD PMID:16030430 PMID:26900785 PMID:27871895 PMID:31568845 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bco1 beta-carotene oxygenase 1 multiple interactions ISO BCO1 affects the reaction [lycopene results in decreased abundance of Testosterone] CTD PMID:21935922 NCBI chr19:45,149,250...45,186,102
Ensembl chr19:45,149,265...45,186,101
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO
EXP
Lycopene inhibits the reaction [Galactose results in decreased expression of BDNF mRNA]; Lycopene inhibits the reaction [Galactose results in decreased expression of BDNF protein]
Lycopene inhibits the reaction [Oxaliplatin results in decreased expression of BDNF protein]
CTD PMID:28974442 PMID:32544411 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Becn1 beclin 1 multiple interactions ISO Lycopene inhibits the reaction [Atrazine results in increased expression of BECN1 mRNA] CTD PMID:30360616 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases expression ISO lycopene results in decreased expression of BRAF protein CTD PMID:17337101 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G C1qa complement C1q A chain decreases expression ISO lycopene results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
JBrowse link
G C4b complement C4B (Chido blood group) decreases expression ISO lycopene results in decreased expression of C4B mRNA CTD PMID:19555370 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Lycopene inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in increased expression of CALCA protein] CTD PMID:33592256 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
[S-allylcysteine co-treated with Lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP3 protein]; Lycopene inhibits the reaction [Atrazine results in increased expression of CASP3 mRNA]; Lycopene inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]; Lycopene inhibits the reaction [Oxaliplatin results in increased expression of CASP3 protein]; Lycopene inhibits the reaction [Sodium Fluoride results in increased activity of CASP3 protein]; Lycopene inhibits the reaction [Sodium Fluoride results in increased expression of CASP3 mRNA]
lycopene inhibits the reaction [Sodium Fluoride results in increased activity of CASP3 protein]; lycopene inhibits the reaction [Sodium Fluoride results in increased expression of CASP3 mRNA]
CTD PMID:16030430 PMID:27102619 PMID:27871895 PMID:31568845 PMID:32544411 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions
decreases expression
EXP
ISO
[S-allylcysteine co-treated with lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]; lycopene inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]
lycopene results in decreased expression of CASP8 mRNA
CTD PMID:16030430 PMID:16886892 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions EXP
ISO
lycopene inhibits the reaction [Sodium Fluoride results in increased expression of CASP9 mRNA]
lycopene inhibits the reaction [Sodium Fluoride results in increased activity of CASP9 protein]; lycopene inhibits the reaction [Sodium Fluoride results in increased expression of CASP9 mRNA]
CTD PMID:27871895 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions
decreases expression
increases activity
increases expression
EXP
ISO
Lycopene affects the reaction [Doxorubicin affects the activity of CAT protein]; Lycopene inhibits the reaction [Atrazine results in decreased activity of CAT protein]; Lycopene inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]; Lycopene inhibits the reaction [Cadmium Chloride results in increased activity of CAT protein]; Lycopene inhibits the reaction [Mercuric Chloride results in increased activity of CAT protein]; Lycopene inhibits the reaction [Oxaliplatin results in decreased activity of CAT protein]; Lycopene inhibits the reaction [Sodium Glutamate results in increased activity of CAT protein]; Lycopene inhibits the reaction [Sodium Glutamate results in increased expression of CAT mRNA]
Lycopene results in decreased expression of CAT mRNA
Lycopene inhibits the reaction [Acetaminophen results in increased activity of CAT protein]; Lycopene inhibits the reaction [Atrazine results in decreased activity of CAT protein]
lycopene results in increased activity of CAT protein
lycopene results in increased expression of CAT
CTD PMID:16325981 PMID:17516994 PMID:17873360 PMID:19450652 PMID:20074268 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO
EXP
lycopene inhibits the reaction [Genistein results in increased expression of CCND1 protein]; lycopene inhibits the reaction [IGF1 protein results in increased expression of CCND1 protein]
lycopene results in decreased expression of CCND1 protein
lycopene inhibits the reaction [[Dietary Fats co-treated with Diethylnitrosamine] results in increased expression of CCND1 protein]
CTD PMID:16565789 PMID:17051425 PMID:17337101 PMID:19551842 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccne1 cyclin E1 decreases expression
increases expression
ISO lycopene results in decreased expression of CCNE1 protein
lycopene results in increased expression of CCNE1 mRNA
CTD PMID:16886892 PMID:17337101 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO lycopene results in decreased expression of CDK1 protein CTD PMID:17337101 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO lycopene results in decreased expression of CDK4 protein CTD PMID:17337101 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk5 cyclin-dependent kinase 5 decreases expression ISO lycopene results in decreased expression of CDK5 protein CTD PMID:17337101 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
JBrowse link
G Cdk7 cyclin-dependent kinase 7 decreases expression ISO lycopene results in decreased expression of CDK7 protein CTD PMID:17337101 NCBI chr 2:31,840,545...31,865,447
Ensembl chr 2:31,840,558...31,865,383
JBrowse link
G Cdk9 cyclin-dependent kinase 9 decreases expression ISO lycopene results in decreased expression of CDK9 protein CTD PMID:17337101 NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO lycopene inhibits the reaction [IGF1 protein results in increased expression of CDKN1A protein] CTD PMID:16565789 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Chga chromogranin A increases expression ISO lycopene results in increased expression of CHGA mRNA CTD PMID:16886892 NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398
JBrowse link
G Chgb chromogranin B decreases expression ISO lycopene results in decreased expression of CHGB mRNA CTD PMID:16886892 NCBI chr 3:120,043,824...120,057,169
Ensembl chr 3:120,043,738...120,057,166
JBrowse link
G Ckb creatine kinase B multiple interactions EXP Lycopene inhibits the reaction [Sodium Glutamate results in increased activity of CKB protein] CTD PMID:26900785 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
JBrowse link
G Crb1 crumbs cell polarity complex component 1 decreases expression ISO lycopene results in decreased expression of CRB1 mRNA CTD PMID:16886892 NCBI chr13:50,801,484...50,989,261
Ensembl chr13:50,800,959...50,989,261
JBrowse link
G Ctss cathepsin S decreases expression ISO lycopene results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 2:183,089,192...183,114,483
Ensembl chr 2:183,086,437...183,114,483
JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 decreases expression ISO lycopene results in decreased expression of CXCL14 mRNA CTD PMID:19555370 NCBI chr17:8,317,933...8,325,956
Ensembl chr17:8,317,933...8,324,839
JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions ISO lycopene inhibits the reaction [Atrazine results in increased expression of CYB5A protein] CTD PMID:26775023 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions EXP lycopene inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of CYP11A1 protein] CTD PMID:19071209 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
multiple interactions
ISO lycopene results in decreased activity of CYP1A1 protein
lycopene inhibits the reaction [Atrazine results in increased expression of CYP1A1 mRNA]
CTD PMID:19329757 PMID:26775023 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO lycopene inhibits the reaction [Atrazine results in increased expression of CYP1A2 mRNA] CTD PMID:26775023 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity
multiple interactions
ISO lycopene results in decreased activity of CYP1B1 protein
lycopene affects the reaction [Atrazine results in increased expression of CYP1B1 mRNA]
CTD PMID:19329757 PMID:26775023 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 decreases expression EXP lycopene results in decreased expression of CYP21A1 mRNA CTD PMID:15084515 NCBI chr20:4,020,217...4,026,923
Ensembl chr20:4,023,767...4,026,923
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO lycopene affects the reaction [Atrazine results in increased expression of CYP2B9 mRNA] CTD PMID:26775023 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO lycopene inhibits the reaction [Atrazine results in increased expression of CYP2E1 mRNA] CTD PMID:26775023 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases activity ISO Lycopene results in increased activity of CYP3A4 protein CTD PMID:16632523 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 multiple interactions ISO lycopene inhibits the reaction [Atrazine results in increased expression of CYP7B1 mRNA] CTD PMID:26775023 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
JBrowse link
G Ddb2 damage specific DNA binding protein 2 increases expression ISO lycopene results in increased expression of DDB2 mRNA CTD PMID:16886892 NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP Lycopene inhibits the reaction [Oxaliplatin results in increased expression of EIF2AK3 mRNA] CTD PMID:32544411 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif4g1 eukaryotic translation initiation factor 4 gamma, 1 increases expression ISO lycopene results in increased expression of EIF4G1 mRNA CTD PMID:16886892 NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP Lycopene inhibits the reaction [Oxaliplatin results in increased expression of ERN1 mRNA] CTD PMID:32544411 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases expression
ISO lycopene inhibits the reaction [Estradiol results in increased activity of ESR1 protein]
lycopene results in increased expression of ESR1 mRNA
CTD PMID:16886892 PMID:17051425 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO lycopene inhibits the reaction [Estradiol results in increased activity of ESR2 protein] CTD PMID:17051425 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fancc FA complementation group C decreases expression ISO lycopene results in decreased expression of FANCC mRNA CTD PMID:16886892 NCBI chr17:1,680,660...1,822,610
Ensembl chr17:1,681,324...1,829,376
JBrowse link
G Fancf FA complementation group F decreases expression ISO lycopene results in decreased expression of FANCF mRNA CTD PMID:16886892 NCBI chr 1:101,449,120...101,452,361
Ensembl chr 1:101,450,389...101,451,923
JBrowse link
G Faslg Fas ligand decreases expression ISO lycopene results in decreased expression of FASLG mRNA CTD PMID:16886892 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO lycopene results in increased expression of FOS mRNA CTD PMID:16886892 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Get1 guided entry of tail-anchored proteins factor 1 decreases expression ISO Lycopene results in decreased expression of GET1 mRNA CTD PMID:16886892 NCBI chr11:35,438,555...35,460,156
Ensembl chr11:35,445,815...35,459,973
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
multiple interactions
ISO
EXP
lycopene results in decreased expression of GFAP mRNA
Lycopene inhibits the reaction [Oxaliplatin results in increased expression of GFAP protein]
CTD PMID:19555370 PMID:32544411 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression
multiple interactions
ISO
EXP
lycopene results in increased expression of GJA1 protein
Lycopene inhibits the reaction [Benzo(a)pyrene results in decreased expression of GJA1 protein]
CTD PMID:16091010 PMID:31568845 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gja4 gap junction protein, alpha 4 decreases expression ISO lycopene results in decreased expression of GJA4 mRNA CTD PMID:16886892 NCBI chr 5:139,633,324...139,635,857
Ensembl chr 5:139,633,287...139,635,925
JBrowse link
G Gja5 gap junction protein, alpha 5 decreases expression
increases expression
ISO lycopene results in decreased expression of GJA5 mRNA
lycopene results in increased expression of GJA5 mRNA
CTD PMID:16886892 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression ISO lycopene results in decreased expression of GPX4 mRNA CTD PMID:16886892 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO lycopene inhibits the reaction [Zearalenone results in decreased activity of GSR protein] CTD PMID:25682699 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions
decreases response to substance
ISO lycopene inhibits the reaction [HMGB1 protein results in increased expression of AGER protein]; lycopene inhibits the reaction [HMGB1 protein results in increased expression of and results in increased secretion of PLA2G2A protein]; lycopene inhibits the reaction [HMGB1 protein results in increased expression of and results in increased secretion of TNF protein]; lycopene inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 mRNA]; lycopene inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 protein]; lycopene inhibits the reaction [HMGB1 protein results in increased expression of SELE mRNA]; lycopene inhibits the reaction [HMGB1 protein results in increased expression of SELE protein]; lycopene inhibits the reaction [HMGB1 protein results in increased expression of TLR2 protein]; lycopene inhibits the reaction [HMGB1 protein results in increased expression of TLR4 protein]; lycopene inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 mRNA]; lycopene inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 protein]; lycopene inhibits the reaction [Lipopolysaccharides results in increased secretion of HMGB1 protein]
lycopene results in decreased susceptibility to HMGB1 protein
CTD PMID:22429818 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP
ISO
lycopene results in increased expression of HMOX1 mRNA; lycopene results in increased expression of HMOX1 protein
Lycopene inhibits the reaction [Atrazine results in increased expression of HMOX1 mRNA]; Lycopene inhibits the reaction [Galactose results in decreased expression of HMOX1 mRNA]
[lycopene co-treated with Hydrogen Peroxide] results in increased expression of HMOX1 protein
lycopene promotes the reaction [Atrazine results in increased expression of HMOX1 mRNA]
CTD PMID:19551842 PMID:27102619 PMID:28974442 PMID:30360616 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions EXP lycopene inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of HSD3B1 protein] CTD PMID:19071209 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 multiple interactions EXP lycopene inhibits the reaction [decamethrin results in increased expression of HSPA4 mRNA] CTD PMID:23076637 NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Lycopene inhibits the reaction [Oxaliplatin results in increased expression of HSPA5 mRNA] CTD PMID:32544411 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; lycopene inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 mRNA]; lycopene inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 protein]; lycopene inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] CTD PMID:22429818 PMID:25551565 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
decreases expression
increases expression
ISO
EXP
lycopene inhibits the reaction [IGF1 protein results in increased expression of CCND1 protein]; lycopene inhibits the reaction [IGF1 protein results in increased expression of CDKN1A protein]; lycopene inhibits the reaction [IGF1 protein results in increased phosphorylation of RB1 protein]
lycopene results in decreased expression of IGF1 mRNA
lycopene results in increased expression of IGF1 mRNA
CTD PMID:15084515 PMID:16565789 PMID:16886892 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression ISO lycopene results in decreased expression of IGF1R protein CTD PMID:17337101 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression ISO lycopene results in increased expression of IGFBP2 protein CTD PMID:17337101 NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] promotes the reaction [TNF protein results in increased expression of and results in increased secretion of IL10 protein]; lycopene promotes the reaction [TNF protein results in increased expression of and results in increased secretion of IL10 protein]
lycopene inhibits the reaction [Zearalenone results in increased expression of IL10]
CTD PMID:25551565 PMID:25682699 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO lycopene inhibits the reaction [Galactose results in increased expression of IL1B protein]; lycopene inhibits the reaction [Zearalenone results in increased expression of IL1B] CTD PMID:25682699 PMID:28974442 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions ISO lycopene inhibits the reaction [Zearalenone results in increased expression of IL2] CTD PMID:25682699 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
EXP
ISO
lycopene results in decreased expression of IL6 mRNA
lycopene inhibits the reaction [Zearalenone results in increased expression of IL6]
CTD PMID:15084515 PMID:25682699 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ivl involucrin decreases expression ISO lycopene results in decreased expression of IVL protein CTD PMID:10769631 NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100
JBrowse link
G Jak1 Janus kinase 1 increases expression ISO lycopene results in increased expression of JAK1 mRNA CTD PMID:16886892 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression ISO lycopene results in decreased expression of JUN mRNA CTD PMID:16886892 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO Lycopene inhibits the reaction [Atrazine results in decreased expression of KEAP1 mRNA] CTD PMID:30360616 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Kif2a kinesin family member 2A increases expression ISO lycopene results in increased expression of KIF2A mRNA CTD PMID:16886892 NCBI chr 2:38,367,998...38,431,237
Ensembl chr 2:38,367,998...38,431,508
JBrowse link
G Kpna2 karyopherin subunit alpha 2 increases expression ISO lycopene results in increased expression of KPNA2 mRNA CTD PMID:16886892 NCBI chr10:91,933,951...91,946,115
Ensembl chr10:91,933,951...91,946,150
JBrowse link
G Ldlr low density lipoprotein receptor increases expression ISO lycopene results in increased expression of LDLR mRNA CTD PMID:16886892 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Lipa lipase A, lysosomal acid type increases expression ISO lycopene results in increased expression of LIPA mRNA CTD PMID:16886892 NCBI chr 1:232,024,351...232,167,329
Ensembl chr 1:232,024,356...232,057,633
JBrowse link
G Lpo lactoperoxidase multiple interactions ISO lycopene inhibits the reaction [Diethylnitrosamine results in increased expression of LPO protein] CTD PMID:24144777 NCBI chr10:72,606,944...72,626,535
Ensembl chr10:72,606,944...72,626,535
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases expression ISO lycopene results in increased expression of MAP2K1 mRNA CTD PMID:16886892 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 decreases expression ISO lycopene results in decreased expression of MAP2K2 protein CTD PMID:17337101 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 decreases expression ISO lycopene results in decreased expression of MAP2K4 protein CTD PMID:17337101 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 decreases expression ISO lycopene results in decreased expression of MAP2K6 protein CTD PMID:17337101 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO
lycopene inhibits the reaction [[Dietary Fats co-treated with Diethylnitrosamine] results in increased phosphorylation of MAPK1 protein]
Lycopene inhibits the reaction [Atrazine results in increased expression of MAPK1 mRNA]
CTD PMID:19551842 PMID:30360616 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases expression
multiple interactions
increases expression
ISO
EXP
lycopene results in decreased expression of MAPK14 protein
Lycopene inhibits the reaction [Oxaliplatin results in increased expression of MAPK14 protein]
lycopene results in increased expression of MAPK14 mRNA
CTD PMID:16886892 PMID:17337101 PMID:32544411 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases expression ISO lycopene results in decreased expression of MAPK3 protein CTD PMID:17337101 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases expression ISO lycopene results in decreased expression of MAPK8 protein CTD PMID:17337101 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mgat2 alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase increases expression ISO lycopene results in increased expression of MGAT2 mRNA CTD PMID:16886892 NCBI chr 6:87,656,360...87,658,849
Ensembl chr 6:87,656,349...87,658,177
JBrowse link
G Mill1 MHC I like leukocyte 1 increases expression ISO Lycopene results in increased expression of MICA mRNA CTD PMID:16886892 NCBI chr 1:78,372,138...78,398,932
Ensembl chr 1:78,372,802...78,398,930
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions EXP Lycopene inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in increased expression of MKI67 protein] CTD PMID:33592256 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mlh1 mutL homolog 1 increases expression ISO lycopene results in increased expression of MLH1 mRNA CTD PMID:16886892 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO lycopene inhibits the reaction [Acetaminophen results in increased activity of MMP2 protein] CTD PMID:27989599 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Msh2 mutS homolog 2 increases expression ISO lycopene results in increased expression of MSH2 mRNA CTD PMID:16886892 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
JBrowse link
G Msh6 mutS homolog 6 increases expression ISO lycopene results in increased expression of MSH6 mRNA CTD PMID:16886892 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions
EXP
ISO
lycopene results in increased expression of NFE2L2 mRNA; lycopene results in increased expression of NFE2L2 protein
Lycopene inhibits the reaction [Atrazine results in increased expression of NFE2L2 mRNA]; Lycopene inhibits the reaction [Atrazine results in increased expression of NFE2L2 protein]
lycopene promotes the reaction [Atrazine results in increased expression of NFE2L2 mRNA]
CTD PMID:19551842 PMID:27102619 PMID:30360616 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP lycopene inhibits the reaction [Atrazine results in increased expression of NFKB1 mRNA] CTD PMID:27102619 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; lycopene inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA] CTD PMID:25551565 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos1 nitric oxide synthase 1 decreases expression ISO lycopene results in decreased expression of NOS1 mRNA CTD PMID:16886892 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO Lycopene inhibits the reaction [Atrazine results in decreased expression of NQO1 protein]; Lycopene inhibits the reaction [Atrazine results in increased expression of NQO1 mRNA]; Lycopene inhibits the reaction [Galactose results in decreased expression of NQO1 mRNA] CTD PMID:28974442 PMID:30360616 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nup214 nucleoporin 214 decreases expression ISO lycopene results in decreased expression of NUP214 mRNA CTD PMID:16886892 NCBI chr 3:15,255,111...15,340,568
Ensembl chr 3:15,255,119...15,340,568
JBrowse link
G P22k15 cystatin related protein 2 decreases expression EXP lycopene results in decreased expression of P22K15 mRNA CTD PMID:15084515 NCBI chr 3:136,960,300...136,967,358
Ensembl chr 3:136,960,303...136,967,358
JBrowse link
G Pah phenylalanine hydroxylase decreases expression ISO lycopene results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP lycopene inhibits the reaction [decamethrin results in increased activity of PARP1 protein] CTD PMID:23076637 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP lycopene inhibits the reaction [[Diethylnitrosamine co-treated with Dietary Fats] results in increased expression of PCNA protein] CTD PMID:19551842 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pla2g2a phospholipase A2 group IIA multiple interactions ISO lycopene inhibits the reaction [HMGB1 protein results in increased expression of and results in increased secretion of PLA2G2A protein] CTD PMID:22429818 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP lycopene inhibits the reaction [Atrazine results in increased secretion of POMC protein modified form] CTD PMID:27102619 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions
increases expression
increases phosphorylation
ISO Lycopene inhibits the reaction [Atrazine results in increased expression of PRKAA2 mRNA]; Lycopene inhibits the reaction [Atrazine results in increased phosphorylation of PRKAA2 protein]
Lycopene results in increased expression of PRKAA2 mRNA
Lycopene results in increased phosphorylation of PRKAA2 protein
CTD PMID:30360616 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 multiple interactions ISO Lycopene inhibits the reaction [Atrazine results in increased expression of PRKAB1 mRNA] CTD PMID:30360616 NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661
JBrowse link
G Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2 multiple interactions ISO Lycopene inhibits the reaction [Atrazine results in decreased expression of PRKAB2 mRNA] CTD PMID:30360616 NCBI chr 2:185,257,218...185,272,846
Ensembl chr 2:185,257,213...185,269,872
JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 multiple interactions ISO Lycopene affects the reaction [Atrazine results in increased expression of PRKAG2 mRNA] CTD PMID:30360616 NCBI chr 4:10,010,574...10,252,152
Ensembl chr 4:10,010,890...10,252,142
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit decreases expression ISO lycopene results in decreased expression of PRKDC mRNA CTD PMID:16886892 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO lycopene inhibits the reaction [Galactose results in increased expression of PTGS2 mRNA] CTD PMID:28974442 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rad50 RAD50 double strand break repair protein increases expression ISO lycopene results in increased expression of RAD50 mRNA CTD PMID:16886892 NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396
JBrowse link
G Rassf7 Ras association domain family member 7 increases expression ISO lycopene results in increased expression of RASSF7 mRNA CTD PMID:16886892 NCBI chr 1:196,319,600...196,323,787
Ensembl chr 1:196,320,902...196,323,770
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
decreases phosphorylation
ISO lycopene inhibits the reaction [Genistein results in increased phosphorylation of and results in decreased activity of RB1 protein]; lycopene inhibits the reaction [IGF1 protein results in increased phosphorylation of RB1 protein]
lycopene results in decreased phosphorylation of RB1 protein
CTD PMID:16565789 PMID:17051425 PMID:17337101 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rdx radixin decreases expression ISO lycopene results in decreased expression of RDX mRNA CTD PMID:16886892 NCBI chr 8:52,379,494...52,437,673
Ensembl chr 8:52,379,494...52,437,678
JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 decreases expression ISO lycopene results in decreased expression of RPS6KA1 protein CTD PMID:17337101 NCBI chr 5:146,079,018...146,118,272
Ensembl chr 5:146,079,021...146,118,272
JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 decreases expression ISO lycopene results in decreased expression of RPS6KA3 protein CTD PMID:17337101 NCBI chr  X:35,517,306...35,623,296
Ensembl chr  X:35,517,306...35,623,207
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 increases expression ISO lycopene results in increased expression of RRM2 mRNA CTD PMID:16886892 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
JBrowse link
G Sbp spermine binding protein decreases expression EXP lycopene results in decreased expression of SBP mRNA CTD PMID:15084515 NCBI chr10:12,946,036...12,968,439
Ensembl chr10:12,946,036...12,968,439
JBrowse link
G Scgb1d2 secretoglobin, family 1D, member 2 decreases expression EXP lycopene results in decreased expression of SCGB1D2 mRNA CTD PMID:15084515 NCBI chr 1:206,228,682...206,233,587
Ensembl chr 1:206,228,778...206,231,785
JBrowse link
G Scgb1d4 secretoglobin family 1D member 4 decreases expression EXP lycopene results in decreased expression of SCGB1D4 mRNA CTD PMID:15084515 NCBI chr 1:206,330,454...206,333,329
Ensembl chr 1:206,330,454...206,333,329
JBrowse link
G Scgb2a1 secretoglobin, family 2A, member 1 decreases expression EXP Lycopene results in decreased expression of SCGB2A2 mRNA CTD PMID:15084515 NCBI chr 1:206,497,848...206,501,211
Ensembl chr 1:206,497,849...206,501,211
Ensembl chr 1:206,497,849...206,501,211
JBrowse link
G Sele selectin E multiple interactions ISO [Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; lycopene inhibits the reaction [HMGB1 protein results in increased expression of SELE mRNA]; lycopene inhibits the reaction [HMGB1 protein results in increased expression of SELE protein]; lycopene inhibits the reaction [TNF protein results in increased expression of SELE mRNA] CTD PMID:22429818 PMID:25551565 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Selenop selenoprotein P decreases expression ISO lycopene results in decreased expression of SELENOP mRNA CTD PMID:16886892 NCBI chr 2:52,498,123...52,508,409
Ensembl chr 2:52,498,339...52,508,852
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO lycopene inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein] CTD PMID:28974442 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Skap2 src kinase associated phosphoprotein 2 decreases expression ISO lycopene results in decreased expression of SKAP2 mRNA CTD PMID:19555370 NCBI chr 4:80,948,832...81,100,900
Ensembl chr 4:80,950,580...81,100,891
JBrowse link
G Smad3 SMAD family member 3 increases expression ISO lycopene results in increased expression of SMAD3 mRNA CTD PMID:16886892 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Smc1a structural maintenance of chromosomes 1A decreases expression ISO lycopene results in decreased expression of SMC1A mRNA CTD PMID:16886892 NCBI chr  X:21,103,323...21,148,053
Ensembl chr  X:21,103,282...21,148,056
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO Lycopene inhibits the reaction [Atrazine results in increased expression of SQSTM1 mRNA alternative form]; Lycopene inhibits the reaction [Atrazine results in increased expression of SQSTM1 mRNA]; Lycopene inhibits the reaction [Atrazine results in increased expression of SQSTM1 protein] CTD PMID:30360616 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 decreases expression EXP lycopene results in decreased expression of SRD5A1 mRNA CTD PMID:15084515 NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP lycopene inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of STAR protein]; lycopene inhibits the reaction [decamethrin results in decreased expression of STAR mRNA] CTD PMID:19071209 PMID:23076637 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression ISO lycopene results in increased expression of STAT3 mRNA CTD PMID:16886892 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tff1 trefoil factor 1 decreases expression ISO lycopene results in decreased expression of TFF1 mRNA CTD PMID:16886892 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 decreases expression ISO lycopene results in decreased expression of TFPI2 mRNA CTD PMID:16886892 NCBI chr 4:31,981,786...31,986,707
Ensembl chr 4:31,982,178...31,986,600
JBrowse link
G Tgfa transforming growth factor alpha increases expression ISO lycopene results in increased expression of TGFA mRNA CTD PMID:16886892 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO lycopene inhibits the reaction [HMGB1 protein results in increased expression of TLR2 protein]; lycopene inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 protein] CTD PMID:22429818 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO lycopene inhibits the reaction [HMGB1 protein results in increased expression of TLR4 protein]; lycopene inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] CTD PMID:22429818 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
[Lycopene co-treated with Diethylnitrosamine] results in increased expression of TNF mRNA; Lycopene inhibits the reaction [Oxaliplatin results in increased expression of TNF protein]
lycopene inhibits the reaction [Galactose results in increased expression of TNF protein]; lycopene inhibits the reaction [Zearalenone results in increased expression of TNF]
[Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of CXCL8 protein]; [Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of TNF protein]; [Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; [Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; [Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; [Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; [Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of TNF mRNA]; [Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] promotes the reaction [TNF protein results in increased expression of and results in increased secretion of IL10 protein]; lycopene inhibits the reaction [HMGB1 protein results in increased expression of and results in increased secretion of TNF protein]; lycopene inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of CXCL8 protein]; lycopene inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of TNF protein]; lycopene inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; lycopene inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; lycopene inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; lycopene inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; lycopene inhibits the reaction [TNF protein results in increased expression of TNF mRNA]; lycopene promotes the reaction [TNF protein results in increased expression of and results in increased secretion of IL10 protein]
CTD PMID:19551842 PMID:22429818 PMID:25551565 PMID:25682699 PMID:28974442 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO lycopene results in decreased expression of TP53 mRNA CTD PMID:16886892 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions EXP Lycopene inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in increased expression of TSHB protein] CTD PMID:33592256 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO lycopene inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 mRNA]; lycopene inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 protein] CTD PMID:22429818 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vcp valosin-containing protein increases expression ISO lycopene results in increased expression of VCP mRNA CTD PMID:16886892 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Lycopene inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in increased expression of VEGFA protein] CTD PMID:33592256 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      chemical role 19316
        antioxidant 14437
          lycopene 185
            lycophyll 0
            lycoxanthin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    main group molecular entity 19693
                      s-block molecular entity 19474
                        hydrogen molecular entity 19466
                          hydrides 18830
                            organic hydride 18346
                              organic fundamental parent 18346
                                hydrocarbon 18057
                                  terpene 12723
                                    tetraterpene 530
                                      carotene 530
                                        carotenoid 530
                                          carotenoid psi-end group 185
                                            lycopene 185
                                              lycophyll 0
                                              lycoxanthin 0
paths to the root