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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:glycyrrhizinic acid
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Accession:CHEBI:15939 term browser browse the term
Definition:A triterpenoid saponin that is the glucosiduronide derivative of 3beta-hydroxy-11-oxoolean-12-en-30-oic acid.
Synonyms:exact_synonym: 30-hydroxy-11,30-dioxoolean-12-en-3beta-yl (2-O-beta-D-glucopyranosyluronic acid)-alpha-D-glucopyranosiduronic acid
 related_synonym: (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl-2-O-beta-D-glucopyranuronosyl-alpha-D-glucopyranosiduronic acid;   Formula=C42H62O16;   Glycyrrhizin;   InChI=1S/C42H62O16/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54)/t19-,21-,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35-,38+,39-,40-,41+,42+/m0/s1;   InChIKey=LPLVUJXQOOQHMX-QWBHMCJMSA-N;   SMILES=[H][C@@]12C[C@](C)(CC[C@]1(C)CC[C@]1(C)C2=CC(=O)[C@]2([H])[C@@]3(C)CC[C@H](O[C@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)C(O)=O)C(O)=O)C(C)(C)[C@]3([H])CC[C@@]12C)C(O)=O;   glycyrrhizic acid
 alt_id: CHEBI:24418;   CHEBI:5508
 xref: CAS:1405-86-3;   Drug_Central:1325;   HMDB:HMDB0029843;   KEGG:C02284;   LIPID_MAPS_instance:LMPR0106150013
 xref_mesh: MESH:D019695
 xref: MetaCyc:GLYCYRRHIZINATE;   PMID:11282481;   PMID:15013279;   PMID:24497916;   Reaxys:77922;   Wikipedia:Glycyrrhizin
 cyclic_relationship: is_conjugate_acid_of CHEBI:29807


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glycyrrhizinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity		 ISO Glycyrrhizic Acid inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Glycyrrhizic Acid results in decreased activity of ABCB11 protein		 CTD PMID:24014644 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO Glycyrrhizic Acid affects the reaction [1-Naphthylisothiocyanate affects the expression of ABCC3 mRNA] CTD PMID:28549656 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ACACA mRNA] CTD PMID:31918260 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 multiple interactions ISO Glycyrrhizic Acid affects the reaction [1-Naphthylisothiocyanate affects the expression of ACAT2 mRNA] CTD PMID:28549656 NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:47,695,788...47,752,821 		JBrowse link
G Ache acetylcholinesterase multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Fusaric Acid results in decreased expression of ACHE protein] CTD PMID:31150628 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions		 ISO
EXP		 Glycyrrhizic Acid results in decreased expression of ACTA2 protein
Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of ACTA2 protein]		 CTD PMID:33030083 PMID:33522686 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein] CTD PMID:32525084 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin multiple interactions ISO
EXP		 ALB protein binds to and affects the transport of Glycyrrhizic Acid
Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of and results in increased secretion of ALB protein]		 CTD PMID:8831264 PMID:19558898 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Aqp2 aquaporin 2 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Gentamicins results in decreased expression of AQP2 protein] CTD PMID:12969435 NCBI chr 7:132,590,286...132,595,321
Ensembl chr 7:130,711,413...130,716,468 		JBrowse link
G Aqp5 aquaporin 5 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Histamine results in decreased expression of AQP5 protein] CTD PMID:29452068 NCBI chr 7:132,601,528...132,605,060
Ensembl chr 7:130,721,748...130,726,209 		JBrowse link
G Ar androgen receptor multiple interactions
affects localization		 ISO Glycyrrhizic Acid binds to and results in increased activity of AR protein
Glycyrrhizic Acid affects the localization of AR protein		 CTD PMID:28478275 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Glycyrrhizic Acid results in increased expression of BAD mRNA CTD PMID:35844403 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Glycyrrhizic Acid results in increased expression of BAX mRNA CTD PMID:35844403 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO Glycyrrhizic Acid results in decreased expression of BCL2 mRNA
[Glycyrrhizic Acid co-treated with Cisplatin] results in decreased expression of BCL2 mRNA		 CTD PMID:35844403 PMID:37659683 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Fusaric Acid results in decreased expression of BDNF protein] CTD PMID:31150628 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Casp2 caspase 2 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in increased activity of CASP2 protein] CTD PMID:22051199 NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 EXP
ISO		 Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in increased activity of CASP3 protein]; Glycyrrhizic Acid inhibits the reaction [Fusaric Acid results in decreased expression of CASP3 protein]
Glycyrrhizic Acid results in increased activity of CASP3 protein
[Glycyrrhizic Acid co-treated with Cisplatin] results in increased expression of CASP3 mRNA		 CTD PMID:22051199 PMID:31150628 PMID:35844403 PMID:37659683 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp6 caspase 6 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in increased activity of CASP6 protein] CTD PMID:22051199 NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity		 EXP
ISO		 Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in increased activity of CASP8 protein]
Glycyrrhizic Acid results in increased activity of CASP8 protein
[Glycyrrhizic Acid co-treated with Cisplatin] results in increased expression of CASP8 mRNA		 CTD PMID:22051199 PMID:35844403 PMID:37659683 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity		 EXP
ISO		 Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in increased activity of CASP9 protein]
Glycyrrhizic Acid results in increased activity of CASP9 protein
[Glycyrrhizic Acid co-treated with Cisplatin] results in increased expression of CASP9 mRNA		 CTD PMID:22051199 PMID:35844403 PMID:37659683 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA] CTD PMID:27585667 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of and results in increased secretion of CCN2 protein]; Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of CCN2 mRNA]; Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of CCN2 protein] CTD PMID:19558898 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Glycyrrhizic Acid results in decreased expression of CCND1 mRNA CTD PMID:35844403 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd68 Cd68 molecule multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of CD68 protein] CTD PMID:33030083 NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO Glycyrrhizic Acid results in increased expression of CDH1 protein CTD PMID:33522686 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Glycyrrhizic Acid results in decreased expression of CDK4 mRNA CTD PMID:35844403 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Glycyrrhizic Acid results in increased expression of CDKN1A mRNA CTD PMID:35844403 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPA mRNA] CTD PMID:34302803 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPB mRNA] CTD PMID:34302803 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Cebpd CCAAT/enhancer binding protein delta multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPD mRNA] CTD PMID:34302803 NCBI chr11:98,268,856...98,269,994
Ensembl chr11:84,764,565...84,765,829 		JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of and results in increased secretion of COL4A1 protein]; Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of COL4A1 protein] CTD PMID:19558898 NCBI chr16:84,885,597...84,996,482
Ensembl chr16:78,183,533...78,294,412 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of CPT1A mRNA] CTD PMID:31918260 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Histamine results in decreased phosphorylation of CREB1 protein] CTD PMID:29452068 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 decreases expression EXP Glycyrrhizic Acid results in decreased expression of CYP11B2 mRNA CTD PMID:10474021 PMID:11798659 NCBI chr 7:108,689,319...108,694,808
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression		 ISO NR1I2 protein affects the reaction [Glycyrrhizic Acid results in increased expression of CYP3A4 mRNA]
Glycyrrhizic Acid results in increased expression of CYP3A4 mRNA; Glycyrrhizic Acid results in increased expression of CYP3A4 protein		 CTD PMID:22982774 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression
multiple interactions		 ISO Glycyrrhizic Acid results in decreased expression of CYP7A1 mRNA
Glycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]		 CTD PMID:22982774 PMID:28549656 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in decreased activity of EPHX2 protein] CTD PMID:22051199 NCBI chr15:44,465,447...44,503,157
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA] CTD PMID:34302803 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of and results in increased secretion of FN1 protein] CTD PMID:19558898 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased secretion of GOT1 protein] CTD PMID:31918260 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO		 Glycyrrhizic Acid inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with BCG Vaccine] results in increased activity of GPT protein]; Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased secretion of GPT protein]
Glycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of GPT protein]; Glycyrrhizic Acid inhibits the reaction [diosbulbin B results in increased activity of GPT protein]		 CTD PMID:19196740 PMID:28549656 PMID:31918260 PMID:37794747 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 decreases expression ISO Glycyrrhizic Acid results in decreased expression of HES1 mRNA CTD PMID:35844403 NCBI chr11:84,210,632...84,213,045
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hmgb1 high mobility group box 1 decreases secretion
decreases activity
multiple interactions		 ISO
EXP		 Glycyrrhizic Acid results in decreased secretion of HMGB1 protein
Glycyrrhizic Acid results in decreased activity of HMGB1 protein
Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of HMGB1 protein]		 CTD PMID:27585667 PMID:27689324 PMID:27783111 PMID:32525084 NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Glycyrrhizic Acid promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 mRNA]; Glycyrrhizic Acid promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 protein] CTD PMID:17917259 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases expression EXP Glycyrrhizic Acid results in decreased expression of HSD11B2 mRNA CTD PMID:10474021 PMID:11798659 NCBI chr19:50,307,569...50,312,812
Ensembl chr19:33,397,656...33,402,899 		JBrowse link
G Ifng interferon gamma affects expression ISO Glycyrrhizic Acid affects the expression of IFNG mRNA CTD PMID:16945185 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO [Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of [IL12A protein binds to IL12B protein]; [Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of IL12A mRNA CTD PMID:11412311 NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO [Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of [IL12A protein binds to IL12B protein]; [Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of IL12B mRNA; [Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of IL12B protein CTD PMID:11412311 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of IL1B protein] CTD PMID:33030083 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]
Glycyrrhizic Acid inhibits the reaction [Chlorpyrifos results in increased expression of IL6 mRNA]; Glycyrrhizic Acid inhibits the reaction [Chlorpyrifos results in increased expression of IL6 protein]
Glycyrrhizic Acid inhibits the reaction [Histamine results in increased expression of IL6 mRNA]; Glycyrrhizic Acid inhibits the reaction [Histamine results in increased secretion of IL6 protein]		 CTD PMID:21644799 PMID:26524701 PMID:29452068 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPA mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPB mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPD mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LPL mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SCD1 mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC2A4 mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased phosphorylation of MAPK1 protein]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein] CTD PMID:34302803 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 decreases expression ISO Glycyrrhizic Acid results in decreased expression of JAG1 mRNA CTD PMID:35844403 NCBI chr 3:144,859,453...144,894,883
Ensembl chr 3:124,406,794...124,442,209 		JBrowse link
G Lpl lipoprotein lipase multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LPL mRNA] CTD PMID:34302803 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP [Glycyrrhizic Acid co-treated with bafilomycin A1] results in increased lipidation of MAP1LC3B protein; Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of and results in increased lipidation of MAP1LC3B protein]; Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased lipidation of MAP1LC3B protein] CTD PMID:32525084 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased phosphorylation of MAPK1 protein] CTD PMID:34302803 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein] CTD PMID:34302803 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Picryl Chloride results in increased secretion of MMP2 protein]
[Glycyrrhizic Acid co-treated with Cisplatin] results in decreased expression of MMP2 mRNA		 CTD PMID:16945185 PMID:37659683 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [Glycyrrhizic Acid co-treated with Cisplatin] results in decreased expression of MMP9 mRNA CTD PMID:37659683 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [diosbulbin B results in increased activity of MPO protein] CTD PMID:37794747 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased phosphorylation of MTOR protein] CTD PMID:32525084 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of MTTP mRNA] CTD PMID:28549656 NCBI chr 2:229,286,501...229,327,650
Ensembl chr 2:226,613,090...226,654,239 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA]; Glycyrrhizic Acid inhibits the reaction [Histamine results in increased secretion of MUC5AC protein] CTD PMID:29452068 NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased activity of [NFKB1 protein binds to RELA protein] CTD PMID:11412311 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Histamine results in increased phosphorylation of NFKBIA protein] CTD PMID:29452068 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein] CTD PMID:17917259 PMID:21644799 PMID:23373965 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Notch1 notch receptor 1 decreases expression ISO Glycyrrhizic Acid results in decreased expression of NOTCH1 mRNA CTD PMID:35844403 NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of NPC1L1 mRNA] CTD PMID:28549656 NCBI chr14:85,285,387...85,305,050
Ensembl chr14:81,071,451...81,091,113 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Glycyrrhizic Acid results in increased expression of NR0B2 mRNA CTD PMID:22982774 NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions		 ISO Glycyrrhizic Acid results in increased activity of NR1I2 protein
NR1I2 protein affects the reaction [Glycyrrhizic Acid results in increased expression of CYP3A4 mRNA]		 CTD PMID:22982774 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta decreases activity ISO Glycyrrhizic Acid results in decreased activity of PIK3CD protein CTD PMID:21644799 NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma decreases activity ISO Glycyrrhizic Acid results in decreased activity of PIK3CG protein CTD PMID:21644799 NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PPARA mRNA] CTD PMID:31918260 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA] CTD PMID:34302803 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 mRNA]; Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein] CTD PMID:17917259 PMID:21644799 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rad21 RAD21 cohesin complex component decreases binding ISO Glycyrrhizinic acid decreases binding of RAD21 protein to SMC3 protein in lymphoma cells RGD PMID:21880767 RGD:243065267 NCBI chr 7:85,177,715...85,204,657
Ensembl chr 7:83,287,870...83,314,817 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP		 [Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased activity of [NFKB1 protein binds to RELA protein]
Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene affects the localization of RELA protein]; Glycyrrhizic Acid inhibits the reaction [Chlorpyrifos results in increased phosphorylation of RELA protein]
Glycyrrhizic Acid inhibits the reaction [Histamine results in increased phosphorylation of RELA protein]		 CTD PMID:11412311 PMID:22051199 PMID:26524701 PMID:29452068 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin decreases activity ISO Glycyrrhizic Acid results in decreased activity of REN protein CTD PMID:20460744 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SCD1 mRNA] CTD PMID:34302803 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] CTD PMID:25162824 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC2A4 mRNA] CTD PMID:34302803 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Slc51b SLC51 subunit beta multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of SLC51B mRNA] CTD PMID:28549656 NCBI chr 8:74,827,047...74,835,109
Ensembl chr 8:65,931,890...65,940,145 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of SLCO1A4 mRNA] CTD PMID:28549656 NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Smad4 SMAD family member 4 decreases expression ISO Glycyrrhizic Acid results in decreased expression of SMAD4 protein CTD PMID:33522686 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Smad7 SMAD family member 7 increases expression ISO Glycyrrhizic Acid results in increased expression of SMAD7 protein CTD PMID:33522686 NCBI chr18:71,263,508...71,291,849
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
G Sod1 superoxide dismutase 1 increases activity ISO Glycyrrhizic Acid results in increased activity of SOD1 protein CTD PMID:37659683 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Glucose results in decreased expression of SOD2 protein] CTD PMID:25162824 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP Glycyrrhizic Acid affects the reaction [Doxorubicin results in increased expression of SQSTM1 protein] CTD PMID:32525084 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of SREBF1 mRNA] CTD PMID:31918260 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of and results in increased secretion of TGFB1 protein]; Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of TGFB1 mRNA]; Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; Glycyrrhizic Acid inhibits the reaction [Glucose results in increased expression of TGFB1 protein]; Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of TGFB1 protein] CTD PMID:19558898 PMID:25162824 PMID:33030083 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases expression ISO Glycyrrhizic Acid results in decreased expression of TGFBR1 protein CTD PMID:33522686 NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 decreases expression ISO Glycyrrhizic Acid results in decreased expression of TGFBR2 protein CTD PMID:33522686 NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Glucose results in decreased expression of TJP1 protein]; Glycyrrhizic Acid inhibits the reaction [Palmitic Acid results in decreased expression of TJP1 protein] CTD PMID:27689324 PMID:27783111 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tjp2 tight junction protein 2 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Glucose results in decreased expression of TJP2 protein]; Glycyrrhizic Acid inhibits the reaction [Palmitic Acid results in decreased expression of TJP2 protein] CTD PMID:27689324 PMID:27783111 NCBI chr 1:231,136,218...231,264,750
Ensembl chr 1:221,709,745...221,838,295 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]
Glycyrrhizic Acid inhibits the reaction [Chlorpyrifos results in increased expression of TNF mRNA]; Glycyrrhizic Acid inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein]; Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of TNF protein]		 CTD PMID:17917259 PMID:21644799 PMID:26524701 PMID:33030083 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO Glycyrrhizic Acid results in increased expression of TP53 mRNA CTD PMID:35844403 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19909
    role 19880
      biological role 19878
        biochemical role 19586
          metabolite 19573
            saponin 501
              triterpenoid saponin 429
                glycyrrhizinic acid 96
Path 2
Term Annotations click to browse term
  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    p-block element atom 19846
                      carbon group element atom 19784
                        carbon atom 19781
                          organic molecular entity 19781
                            heteroorganic entity 19540
                              organochalcogen compound 19301
                                organooxygen compound 19216
                                  carbohydrates and carbohydrate derivatives 15321
                                    carbohydrate 15321
                                      carbohydrate derivative 14345
                                        glycosyl compound 13086
                                          glycoside 11860
                                            glycosiduronic acid 205
                                              glucosiduronic acid 205
                                                glycyrrhizinic acid 96
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