CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: columbamine
Accession: CHEBI:15920
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Definition: A berberine alkaloid that has formula C20H20NO4.
Synonyms: exact_synonym: 2-hydroxy-3,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium
related_synonym: 5,6-dihydro-2-hydroxy-3,9,10-trimethoxydibenzo[a,g]quinolizinium; Formula=C20H20NO4; InChI=1S/C20H19NO4/c1-23-18-5-4-12-8-16-14-10-17(22)19(24-2)9-13(14)6-7-21(16)11-15(12)20(18)25-3/h4-5,8-11H,6-7H2,1-3H3/p+1; InChIKey=YYFOFDHQVIODOQ-UHFFFAOYSA-O; SMILES=COc1cc2CC[n+]3cc4c(OC)c(OC)ccc4cc3-c2cc1O
alt_id: CHEBI:14014; CHEBI:23363; CHEBI:3827
xref: CAS:3621-36-1; KEGG:C01795; KNApSAcK:C00024667
xref_mesh: MESH:C055786
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Cdh5
cadherin 5
increases expression
ISO
columbamine results in increased expression of CDH5 mRNA
CTD
PMID:23124089
NCBI chr19:1,025,122...1,074,333
Ensembl chr19:1,023,683...1,074,365
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Cdk6
cyclin-dependent kinase 6
decreases expression
ISO
columbamine results in decreased expression of CDK6 mRNA; columbamine results in decreased expression of CDK6 protein
CTD
PMID:23124089
NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
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Csf2
colony stimulating factor 2
multiple interactions
ISO
columbamine inhibits the reaction [CSF2 protein results in increased phosphorylation of STAT3 protein]
CTD
PMID:23124089
NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
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Ephb2
Eph receptor B2
decreases expression
ISO
columbamine results in decreased expression of EPHB2 mRNA
CTD
PMID:23124089
NCBI chr 5:155,024,478...155,143,539
Ensembl chr 5:155,022,493...155,204,456
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Maged1
MAGE family member D1
decreases expression
ISO
columbamine results in decreased expression of MAGED1 mRNA
CTD
PMID:23124089
NCBI chr X:63,803,194...63,809,715
Ensembl chr X:63,803,189...63,809,861
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Mmp2
matrix metallopeptidase 2
decreases expression
ISO
columbamine results in decreased expression of MMP2 mRNA
CTD
PMID:23124089
NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
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Sox17
SRY-box transcription factor 17
decreases expression
ISO
columbamine results in decreased expression of SOX17 mRNA
CTD
PMID:23124089
NCBI chr 5:14,890,318...14,895,907
Ensembl chr 5:14,890,408...14,895,907
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Stat3
signal transducer and activator of transcription 3
multiple interactions
ISO
columbamine inhibits the reaction [CSF2 protein results in increased phosphorylation of STAT3 protein]
CTD
PMID:23124089
NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
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