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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:columbamine
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Accession:CHEBI:15920 term browser browse the term
Definition:A berberine alkaloid that has formula C20H20NO4.
Synonyms:exact_synonym: 2-hydroxy-3,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium
 related_synonym: 5,6-dihydro-2-hydroxy-3,9,10-trimethoxydibenzo[a,g]quinolizinium;   Formula=C20H20NO4;   InChI=1S/C20H19NO4/c1-23-18-5-4-12-8-16-14-10-17(22)19(24-2)9-13(14)6-7-21(16)11-15(12)20(18)25-3/h4-5,8-11H,6-7H2,1-3H3/p+1;   InChIKey=YYFOFDHQVIODOQ-UHFFFAOYSA-O;   SMILES=COc1cc2CC[n+]3cc4c(OC)c(OC)ccc4cc3-c2cc1O
 alt_id: CHEBI:14014;   CHEBI:23363;   CHEBI:3827
 xref: CAS:3621-36-1;   KEGG:C01795;   KNApSAcK:C00024667
 xref_mesh: MESH:C055786

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columbamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh5 cadherin 5 increases expression ISO columbamine results in increased expression of CDH5 mRNA CTD PMID:23124089 NCBI chr19:1,025,122...1,074,333
Ensembl chr19:1,023,683...1,074,365 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO columbamine results in decreased expression of CDK6 mRNA; columbamine results in decreased expression of CDK6 protein CTD PMID:23124089 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO columbamine inhibits the reaction [CSF2 protein results in increased phosphorylation of STAT3 protein] CTD PMID:23124089 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070 		JBrowse link
G Ephb2 Eph receptor B2 decreases expression ISO columbamine results in decreased expression of EPHB2 mRNA CTD PMID:23124089 NCBI chr 5:155,024,478...155,143,539
Ensembl chr 5:155,022,493...155,204,456 		JBrowse link
G Maged1 MAGE family member D1 decreases expression ISO columbamine results in decreased expression of MAGED1 mRNA CTD PMID:23124089 NCBI chr  X:63,803,194...63,809,715
Ensembl chr  X:63,803,189...63,809,861 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO columbamine results in decreased expression of MMP2 mRNA CTD PMID:23124089 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Sox17 SRY-box transcription factor 17 decreases expression ISO columbamine results in decreased expression of SOX17 mRNA CTD PMID:23124089 NCBI chr 5:14,890,318...14,895,907
Ensembl chr 5:14,890,408...14,895,907 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO columbamine inhibits the reaction [CSF2 protein results in increased phosphorylation of STAT3 protein] CTD PMID:23124089 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      biological role 19825
        biochemical role 19360
          metabolite 19341
            alkaloid 5372
              isoquinoline alkaloid 1130
                berberine alkaloid 359
                  columbamine 8
                    (S)-tetrahydrocolumbamine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic molecule 19586
                              organic cyclic compound 19395
                                organic heterocyclic compound 18511
                                  organonitrogen heterocyclic compound 17579
                                    dibenzoquinolizine 359
                                      berberine alkaloid 359
                                        columbamine 8
                                          (S)-tetrahydrocolumbamine 0
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