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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2-deoxy-D-glucose
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Accession:CHEBI:15866 term browser browse the term
Definition:A deoxyglucose that is D-glucose in which the hydroxy group at position 2 has been replaced by a hydrogen. It is an antimetabolite of glucose with antiviral activity, which acts by inhibiting the glycosylation of glycoproteins and glycolipids. Used as an antiherpes agent.
Synonyms:related_synonym: 2-Deoxy-D-arabino-hexose;   2-Deoxy-D-mannose;   D-2dGlc;   D-arabino-2-Deoxyhexose;   Deoxyglucose;   Formula=C6H12O5
 alt_id: CHEBI:1078;   CHEBI:11565;   CHEBI:11569;   CHEBI:19553;   CHEBI:57546
 xref: CAS:154-17-6;   KEGG:C00586
 xref_mesh: MESH:D003847
 xref: MetaCyc:2-DEOXY-D-GLUCOSE;   Wikipedia:2-Deoxy-D-glucose

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2-deoxy-D-glucose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2M alpha-2-macroglobulin increases uptake
multiple interactions		 EXP A2M protein modified form results in increased uptake of Deoxyglucose
HSPA5 protein affects the reaction [A2M protein modified form results in increased uptake of Deoxyglucose]		 CTD PMID:25720493 NCBI chr12:9,067,708...9,116,229
Ensembl chr12:9,067,664...9,116,229 		JBrowse link
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP Deoxyglucose inhibits the reaction [ABCB1 protein results in increased export of Diazinon] CTD PMID:16221533 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABCC9 ATP binding cassette subfamily C member 9 multiple interactions ISO [Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]; Glyburide inhibits the reaction [[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]] CTD PMID:28842488 NCBI chr12:21,797,389...21,941,863
Ensembl chr12:21,797,401...21,942,529
Ensembl chr12:21,797,401...21,942,529 		JBrowse link
G ABRA actin binding Rho activating protein multiple interactions
increases uptake		 ISO CCG 1423 promotes the reaction [ABRA mutant form promotes the reaction [INS1 protein results in increased uptake of Deoxyglucose]]; CCG 1423 promotes the reaction [ABRA mutant form results in increased uptake of Deoxyglucose]; CCG 1423 promotes the reaction [INS1 protein promotes the reaction [ABRA mutant form results in increased uptake of Deoxyglucose]]; INS1 protein promotes the reaction [ABRA mutant form results in increased uptake of Deoxyglucose] CTD PMID:21393865 NCBI chr 8:106,759,483...106,809,073
Ensembl chr 8:106,759,483...106,770,244 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions
increases uptake		 EXP Indinavir inhibits the reaction [ADIPOQ protein modified form results in increased uptake of Deoxyglucose] CTD PMID:29991592 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G AGRP agouti related neuropeptide increases expression ISO Deoxyglucose results in increased expression of AGRP mRNA CTD PMID:10683841 NCBI chr16:67,482,571...67,483,547
Ensembl chr16:67,482,571...67,483,813
Ensembl chr16:67,482,571...67,483,813 		JBrowse link
G APP amyloid beta precursor protein multiple interactions EXP [Sodium Azide co-treated with Deoxyglucose] affects the cleavage of and affects the localization of APP protein CTD PMID:17405930 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128 		JBrowse link
G ATG3 autophagy related 3 multiple interactions EXP Deoxyglucose affects the reaction [demycarosyl-3D-digitoxosylmithramycin SK affects the expression of ATG3 mRNA] CTD PMID:26079942 NCBI chr 3:112,532,510...112,561,962
Ensembl chr 3:112,532,510...112,562,046 		JBrowse link
G ATG4B autophagy related 4B cysteine peptidase multiple interactions EXP [demycarosyl-3D-digitoxosylmithramycin SK co-treated with Deoxyglucose] results in increased expression of ATG4B mRNA CTD PMID:26079942 NCBI chr 2:241,637,659...241,673,857
Ensembl chr 2:241,637,213...241,673,857 		JBrowse link
G ATG7 autophagy related 7 multiple interactions EXP ATG7 protein inhibits the reaction [Deoxyglucose results in increased cleavage of CASP3 protein]; ATG7 protein inhibits the reaction [Deoxyglucose results in increased expression of DDIT3 protein]; ATG7 protein inhibits the reaction [Deoxyglucose results in increased expression of HSPA5 protein]; ATG7 protein promotes the reaction [Deoxyglucose results in increased prenylation of MAP1LC3B protein] CTD PMID:20593179 NCBI chr 3:11,272,348...11,564,652
Ensembl chr 3:11,272,309...11,557,665 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
decreases expression		 EXP Deoxyglucose promotes the reaction [arsenic trioxide results in increased localization of and results in increased activity of BAX protein]; Deoxyglucose results in increased localization of and results in increased activity of BAX protein
Deoxyglucose results in decreased expression of BAX mRNA		 CTD PMID:23041229 PMID:26079942 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP Deoxyglucose affects the reaction [demycarosyl-3D-digitoxosylmithramycin SK affects the expression of BCL2 mRNA] CTD PMID:26079942 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2L1 BCL2 like 1 decreases response to substance ISO BCL2L1 protein results in decreased susceptibility to Deoxyglucose CTD PMID:10679475 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G BECN1 beclin 1 multiple interactions EXP [bafilomycin A co-treated with Deoxyglucose co-treated with demycarosyl-3D-digitoxosylmithramycin SK] results in decreased expression of BECN1 protein; [demycarosyl-3D-digitoxosylmithramycin SK co-treated with Deoxyglucose] results in increased expression of BECN1 mRNA CTD PMID:26079942 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350 		JBrowse link
G BID BH3 interacting domain death agonist multiple interactions EXP Deoxyglucose promotes the reaction [arsenic trioxide results in increased cleavage of and results in increased activity of BID protein]; Deoxyglucose results in increased cleavage of and results in increased activity of BID protein CTD PMID:23041229 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity
increases cleavage		 EXP
ISO		 ATG7 protein inhibits the reaction [Deoxyglucose results in increased cleavage of CASP3 protein]; Deoxyglucose promotes the reaction [arsenic trioxide results in increased cleavage of and results in increased activity of CASP3 protein]; Deoxyglucose results in increased cleavage of and results in increased activity of CASP3 protein
Deoxyglucose promotes the reaction [Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]]
Deoxyglucose results in increased activity of CASP3 protein
Corticosterone inhibits the reaction [Deoxyglucose results in increased activity of CASP3 protein]; GPX4 protein inhibits the reaction [Deoxyglucose results in increased activity of CASP3 protein]		 CTD PMID:10506188 PMID:15755911 PMID:20593179 PMID:23041229 PMID:29095437 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509 		JBrowse link
G CASP9 caspase 9 multiple interactions EXP [Deoxyglucose co-treated with Cisplatin] results in increased activity of CASP9 protein; Deoxyglucose promotes the reaction [Arsenic Trioxide results in increased cleavage of and results in increased activity of CASP9 protein]; Deoxyglucose results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:20138251 PMID:23041229 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions EXP [demycarosyl-3D-digitoxosylmithramycin SK co-treated with Deoxyglucose] results in increased expression of CDKN1A mRNA CTD PMID:26079942 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339 		JBrowse link
G CHRM3 cholinergic receptor muscarinic 3 affects response to substance ISO CHRM3 protein affects the susceptibility to Deoxyglucose CTD PMID:14724830 NCBI chr 1:239,386,565...239,915,450
Ensembl chr 1:239,386,565...239,915,452 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex affects localization EXP Deoxyglucose analog affects the localization of CHUK protein CTD PMID:27931795 NCBI chr10:100,188,300...100,229,610
Ensembl chr10:100,188,300...100,229,596 		JBrowse link
G CTSD cathepsin D increases expression ISO Deoxyglucose results in increased expression of CTSD protein CTD PMID:20026095 NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,755...1,764,573
Ensembl chr11:1,752,755...1,764,573 		JBrowse link
G CUL7 cullin 7 multiple interactions ISO [INS1 protein co-treated with CUL7 mutant form] results in increased uptake of Deoxyglucose CTD PMID:24219910 NCBI chr 6:43,037,617...43,053,945
Ensembl chr 6:43,037,617...43,053,945
Ensembl chr 6:43,037,617...43,053,945 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions
increases expression		 EXP ATG7 protein inhibits the reaction [Deoxyglucose results in increased expression of DDIT3 protein]; Mannose inhibits the reaction [Deoxyglucose results in increased expression of DDIT3 protein] CTD PMID:20593179 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737 		JBrowse link
G EGFR epidermal growth factor receptor multiple interactions
increases import		 EXP AICA ribonucleotide inhibits the reaction [EGFR protein results in increased import of Deoxyglucose]
EGFR protein mutant form results in increased import of Deoxyglucose		 CTD PMID:19625624 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628 		JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions EXP Deoxyglucose results in decreased phosphorylation of and results in increased expression of EIF4EBP1 protein CTD PMID:23363784 NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365 		JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 multiple interactions EXP [Deoxyglucose co-treated with Quercetin] results in increased ubiquitination of ERBB2 protein; Deoxyglucose inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]] CTD PMID:18655187 NCBI chr17:39,688,094...39,728,660
Ensembl chr17:39,687,914...39,730,426 		JBrowse link
G FXYD2 FXYD domain containing ion transport regulator 2 multiple interactions
increases transport		 EXP Calcium inhibits the reaction [FXYD2 protein results in increased transport of Deoxyglucose] CTD PMID:11533133 NCBI chr11:117,820,057...117,828,089
Ensembl chr11:117,800,844...117,828,698 		JBrowse link
G GALR1 galanin receptor 1 increases expression ISO Deoxyglucose results in increased expression of GALR1 mRNA CTD PMID:9858361 PMID:9928191 NCBI chr18:77,249,848...77,277,900
Ensembl chr18:77,249,848...77,277,900
Ensembl chr18:77,249,848...77,277,900 		JBrowse link
G GCG glucagon multiple interactions
increases secretion		 ISO Capsaicin inhibits the reaction [Deoxyglucose results in increased secretion of GCG protein] CTD PMID:1378463 NCBI chr 2:162,142,882...162,152,247
Ensembl chr 2:162,142,882...162,152,404 		JBrowse link
G GPX4 glutathione peroxidase 4 multiple interactions ISO GPX4 protein inhibits the reaction [Deoxyglucose results in increased activity of CASP3 protein] CTD PMID:10506188 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,926...1,106,791 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions EXP Deoxyglucose inhibits the reaction [arsenic trioxide results in increased phosphorylation of GSK3B protein]; Deoxyglucose inhibits the reaction [Fenretinide results in increased phosphorylation of GSK3B protein] CTD PMID:25246272 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417 		JBrowse link
G H2AX H2A.X variant histone decreases expression EXP Deoxyglucose results in decreased expression of H2AX protein CTD PMID:23363784 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,854...119,095,467 		JBrowse link
G HK2 hexokinase 2 multiple interactions EXP Deoxyglucose results in decreased expression of and results in decreased activity of HK2 protein CTD PMID:32619556 NCBI chr 2:74,834,126...74,893,359
Ensembl chr 2:74,834,127...74,893,359
Ensembl chr 2:74,834,127...74,893,359 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions EXP Deoxyglucose inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 protein]; Deoxyglucose inhibits the reaction [Fenretinide results in increased expression of HMOX1 protein] CTD PMID:25246272 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207 		JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 multiple interactions EXP Deoxyglucose inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]] CTD PMID:18655187 NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,738...102,139,699
Ensembl chr14:102,080,738...102,139,699 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 multiple interactions
increases expression		 EXP 4-Quinolones analog inhibits the reaction [Deoxyglucose results in increased expression of HSP90B1 protein] CTD PMID:31022492 NCBI chr12:103,930,410...103,947,926
Ensembl chr12:103,930,107...103,953,645
Ensembl chr12:103,930,107...103,953,645 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression		 EXP 4-Quinolones analog inhibits the reaction [Deoxyglucose results in increased expression of HSPA5 mRNA]; 4-Quinolones analog inhibits the reaction [Deoxyglucose results in increased expression of HSPA5 protein]; ATG7 protein inhibits the reaction [Deoxyglucose results in increased expression of HSPA5 protein]; HSPA5 protein affects the reaction [A2M protein modified form results in increased uptake of Deoxyglucose]; HSPA5 protein affects the reaction [INS protein results in increased uptake of Deoxyglucose]; Mannose inhibits the reaction [Deoxyglucose results in increased expression of HSPA5 protein]; Oxygen deficiency inhibits the reaction [Deoxyglucose results in increased expression of HSPA5 protein]
Deoxyglucose results in increased expression of HSPA5 mRNA; Deoxyglucose results in increased expression of HSPA5 protein		 CTD PMID:20593179 PMID:25720493 PMID:31022492 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,343 		JBrowse link
G HTRA2 HtrA serine peptidase 2 multiple interactions
decreases localization		 EXP Deoxyglucose promotes the reaction [arsenic trioxide results in decreased localization of HTRA2 protein]
Deoxyglucose results in decreased localization of HTRA2 protein		 CTD PMID:23041229 NCBI chr 2:74,529,405...74,533,556
Ensembl chr 2:74,529,725...74,533,332
Ensembl chr 2:74,529,725...74,533,332 		JBrowse link
G IGF1R insulin like growth factor 1 receptor multiple interactions EXP Deoxyglucose results in increased phosphorylation of and results in increased activity of IGF1R protein CTD PMID:23041229 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530 		JBrowse link
G IL1B interleukin 1 beta decreases response to substance
multiple interactions		 EXP Deoxyglucose results in decreased susceptibility to IL1B protein
Deoxyglucose inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]		 CTD PMID:21211511 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G INS insulin increases uptake
multiple interactions		 EXP
ISO		 INS protein results in increased uptake of Deoxyglucose; INS results in increased uptake of Deoxyglucose
METRNL protein inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]; PPARA protein promotes the reaction [GW 7647 promotes the reaction [INS protein results in increased uptake of Deoxyglucose]]
3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]]; 4-phenylbutyric acid inhibits the reaction [Glucosamine inhibits the reaction [INS results in increased uptake of Deoxyglucose]]; Glucosamine inhibits the reaction [INS results in increased uptake of Deoxyglucose]; GW 7647 promotes the reaction [INS protein results in increased uptake of Deoxyglucose]; HSPA5 protein affects the reaction [INS protein results in increased uptake of Deoxyglucose]; Palmitates inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]; Palmitic Acid inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]; SLC2A1 protein inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]; tin protoporphyrin IX inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]]]; TNF protein inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]; Troglitazone inhibits the reaction [TNF protein inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]]; ursodoxicoltaurine inhibits the reaction [Glucosamine inhibits the reaction [INS results in increased uptake of Deoxyglucose]]		 CTD PMID:2173694 PMID:16483873 PMID:20165829 PMID:21324916 PMID:25720493 PMID:25815690 PMID:30213948 PMID:31877369 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,341
Ensembl chr11:2,159,779...2,161,341 		JBrowse link
G ITGB1 integrin subunit beta 1 decreases expression EXP Deoxyglucose analog results in decreased expression of ITGB1 protein CTD PMID:27931795 NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,900,318...33,005,792
Ensembl chr10:32,900,318...33,005,792 		JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity		 EXP [Deoxyglucose co-treated with Glucose deficiency] results in decreased activity of KCNH2 protein; Deoxyglucose inhibits the reaction [Glucose results in decreased activity of KCNH2 protein]; Deoxyglucose promotes the reaction [Glucose deficiency results in decreased activity of KCNH2 protein]; Pyruvic Acid inhibits the reaction [[Deoxyglucose co-treated with Glucose deficiency] results in decreased activity of KCNH2 protein]
Deoxyglucose results in decreased activity of KCNH2 protein		 CTD PMID:12531891 NCBI chr 7:150,944,956...150,978,321
Ensembl chr 7:150,944,961...150,978,321 		JBrowse link
G KCNJ11 potassium inwardly rectifying channel subfamily J member 11 multiple interactions ISO [Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]; Glyburide inhibits the reaction [[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]] CTD PMID:28842488 NCBI chr11:17,385,246...17,389,346
Ensembl chr11:17,385,859...17,389,331
Ensembl chr11:17,385,859...17,389,331 		JBrowse link
G LEP leptin multiple interactions
decreases secretion		 ISO [Deoxyglucose results in decreased abundance of Adenosine Triphosphate] which results in decreased secretion of LEP protein
Deoxyglucose results in decreased secretion of LEP protein		 CTD PMID:10780946 NCBI chr 7:128,241,201...128,257,629
Ensembl chr 7:128,241,278...128,257,629 		JBrowse link
G MAP1LC3A microtubule associated protein 1 light chain 3 alpha multiple interactions EXP Deoxyglucose affects the reaction [demycarosyl-3D-digitoxosylmithramycin SK affects the expression of MAP1LC3A mRNA] CTD PMID:26079942 NCBI chr20:34,546,823...34,560,345
Ensembl chr20:34,546,854...34,560,345 		JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions
increases prenylation		 EXP ATG7 protein promotes the reaction [Deoxyglucose results in increased prenylation of MAP1LC3B protein]; Mannose inhibits the reaction [Deoxyglucose results in increased prenylation of MAP1LC3B protein]; Oxygen deficiency inhibits the reaction [Deoxyglucose results in increased prenylation of MAP1LC3B protein] CTD PMID:20593179 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP Arsenic Trioxide inhibits the reaction [Deoxyglucose results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Deoxyglucose results in increased phosphorylation of and results in increased activity of MAPK1 protein; PQ 401 inhibits the reaction [Deoxyglucose results in increased phosphorylation of and results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [Deoxyglucose results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:23041229 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO
EXP		 MAPK3 protein affects the reaction [AICA ribonucleotide results in increased uptake of Deoxyglucose]
arsenic trioxide inhibits the reaction [Deoxyglucose results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Deoxyglucose results in increased phosphorylation of and results in increased activity of MAPK3 protein; PQ 401 inhibits the reaction [Deoxyglucose results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [Deoxyglucose results in increased phosphorylation of and results in increased activity of MAPK3 protein]		 CTD PMID:11978788 PMID:23041229 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G METRNL meteorin like, glial cell differentiation regulator multiple interactions ISO METRNL protein inhibits the reaction [INS protein results in increased uptake of Deoxyglucose] CTD PMID:30213948 NCBI chr17:83,079,609...83,095,122
Ensembl chr17:83,079,609...83,095,122 		JBrowse link
G MMP13 matrix metallopeptidase 13 multiple interactions
decreases expression		 EXP Deoxyglucose inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; Deoxyglucose inhibits the reaction [TNF protein results in increased expression of MMP13 protein]
Deoxyglucose analog results in decreased expression of MMP13 protein		 CTD PMID:21211511 PMID:27931795 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732 		JBrowse link
G MMP9 matrix metallopeptidase 9 decreases expression EXP Deoxyglucose analog results in decreased expression of MMP9 protein CTD PMID:27931795 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions EXP Deoxyglucose results in decreased phosphorylation of and results in increased expression of MTOR protein; Deoxyglucose results in increased phosphorylation of and results in increased activity of MTOR protein CTD PMID:23041229 PMID:23363784 NCBI chr 1:11,106,535...11,273,497
Ensembl chr 1:11,106,535...11,262,551 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions
decreases expression		 EXP [demycarosyl-3D-digitoxosylmithramycin SK co-treated with Deoxyglucose] affects the expression of NFKB1 mRNA
Deoxyglucose results in decreased expression of NFKB1 mRNA		 CTD PMID:26079942 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions EXP Deoxyglucose promotes the reaction [STO 609 inhibits the reaction [Histamine results in increased phosphorylation of NOS2 protein]] CTD PMID:21145922 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NPY neuropeptide Y increases expression ISO Deoxyglucose results in increased expression of NPY mRNA CTD PMID:10683841 NCBI chr 7:24,284,190...24,291,862
Ensembl chr 7:24,284,188...24,291,862 		JBrowse link
G OAT ornithine aminotransferase multiple interactions ISO Deoxyglucose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] CTD PMID:2827574 NCBI chr10:124,397,303...124,418,923
Ensembl chr10:124,397,303...124,418,976 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 EXP
ISO		 Deoxyglucose inhibits the reaction [arsenic trioxide results in increased cleavage of PARP1 protein]; Deoxyglucose inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]
Deoxyglucose promotes the reaction [Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein modified form]]
Deoxyglucose results in increased cleavage of PARP1 protein		 CTD PMID:25246272 PMID:29095437 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093 		JBrowse link
G PMCH pro-melanin concentrating hormone increases expression ISO Deoxyglucose results in increased expression of PMCH mRNA CTD PMID:10683841 NCBI chr12:102,196,459...102,199,540
Ensembl chr12:102,196,459...102,197,833 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions ISO PPARA protein promotes the reaction [GW 7647 promotes the reaction [INS protein results in increased uptake of Deoxyglucose]] CTD PMID:21324916 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma affects uptake
increases uptake		 ISO PPARG protein affects the uptake of Deoxyglucose
PPARG gene polymorphism results in increased uptake of Deoxyglucose		 CTD PMID:18083318 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PPP3CA protein phosphatase 3 catalytic subunit alpha decreases response to substance ISO PPP3CA protein results in decreased susceptibility to Deoxyglucose CTD PMID:10679475 NCBI chr 4:101,023,418...101,348,295
Ensembl chr 4:101,023,409...101,348,278 		JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO RAF1 protein affects the reaction [AICA ribonucleotide results in increased uptake of Deoxyglucose] CTD PMID:11978788 NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,583,601...12,664,226
Ensembl chr 3:12,583,601...12,664,226 		JBrowse link
G RPS6 ribosomal protein S6 decreases phosphorylation EXP Deoxyglucose results in decreased phosphorylation of RPS6 protein CTD PMID:23363784 NCBI chr 9:19,375,715...19,380,236
Ensembl chr 9:19,375,715...19,380,236 		JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 decreases phosphorylation
multiple interactions		 EXP Deoxyglucose results in decreased phosphorylation of RPS6KB1 protein
Deoxyglucose results in increased phosphorylation of and results in increased activity of RPS6KB1 protein; oxophenylarsine inhibits the reaction [Deoxyglucose results in decreased phosphorylation of RPS6KB1 protein]		 CTD PMID:16183647 PMID:23041229 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574 		JBrowse link
G SERPINB5 serpin family B member 5 increases expression EXP Deoxyglucose analog results in increased expression of SERPINB5 protein CTD PMID:27931795 NCBI chr18:63,476,958...63,505,085
Ensembl chr18:63,476,958...63,505,085 		JBrowse link
G SLC2A1 solute carrier family 2 member 1 multiple interactions
increases uptake		 ISO
EXP		 [arsenite affects the localization of SLC2A1 protein] which results in increased uptake of Deoxyglucose
SLC2A1 protein results in increased uptake of Deoxyglucose
SLC2A1 protein inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]		 CTD PMID:2173694 PMID:14511371 NCBI chr 1:42,925,353...42,958,868
Ensembl chr 1:42,925,353...42,958,893
Ensembl chr 1:42,925,353...42,958,893 		JBrowse link
G SLC2A2 solute carrier family 2 member 2 multiple interactions
increases transport		 EXP Cytochalasin B inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]; Fructose inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]; Glucose inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]; Maltose inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose] CTD PMID:8457197 NCBI chr 3:170,996,341...171,026,721
Ensembl chr 3:170,996,347...171,026,743 		JBrowse link
G SLC2A3 solute carrier family 2 member 3 multiple interactions
increases transport		 EXP Cytochalasin B inhibits the reaction [SLC2A3 protein results in increased transport of Deoxyglucose]; Galactose inhibits the reaction [SLC2A3 protein results in increased transport of Deoxyglucose]; Glucose inhibits the reaction [SLC2A3 protein results in increased transport of Deoxyglucose]; Maltose inhibits the reaction [SLC2A3 protein results in increased transport of Deoxyglucose] CTD PMID:8457197 NCBI chr12:7,919,230...7,936,187
Ensembl chr12:7,919,230...7,936,187 		JBrowse link
G SLC2A4 solute carrier family 2 member 4 multiple interactions
increases uptake		 ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [mangiferin promotes the reaction [SLC2A4 protein results in increased uptake of Deoxyglucose]]; [arsenite affects the localization of SLC2A4 protein] which results in increased uptake of Deoxyglucose; mangiferin promotes the reaction [SLC2A4 protein results in increased uptake of Deoxyglucose]; Plant Extracts promotes the reaction [SLC2A4 protein results in increased uptake of Deoxyglucose]
[Indinavir results in decreased activity of SLC2A4 protein] inhibits the reaction [resveratrol results in increased uptake of Deoxyglucose]; SLC2A4 promotes the reaction [INS1 protein results in increased uptake of Deoxyglucose]; SLC2A4 protein promotes the reaction [resveratrol results in increased uptake of Deoxyglucose]		 CTD PMID:14511371 PMID:18601907 PMID:19477051 PMID:20206685 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257 		JBrowse link
G SLC2A8 solute carrier family 2 member 8 increases uptake ISO SLC2A8 protein results in increased uptake of Deoxyglucose CTD PMID:23396969 NCBI chr 9:127,397,140...127,407,898
Ensembl chr 9:127,397,138...127,408,424 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions EXP Deoxyglucose inhibits the reaction [manganese chloride results in increased expression of SOD2 mRNA]; Deoxyglucose inhibits the reaction [manganese chloride results in increased expression of SOD2 protein] CTD PMID:10328827 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G SQSTM1 sequestosome 1 multiple interactions EXP [bafilomycin A co-treated with Deoxyglucose co-treated with demycarosyl-3D-digitoxosylmithramycin SK] affects the expression of SQSTM1 protein; [bafilomycin A co-treated with Deoxyglucose] affects the expression of SQSTM1 protein; Deoxyglucose inhibits the reaction [demycarosyl-3D-digitoxosylmithramycin SK results in decreased expression of SQSTM1 mRNA]; Deoxyglucose promotes the reaction [demycarosyl-3D-digitoxosylmithramycin SK results in decreased expression of SQSTM1 mRNA] CTD PMID:26079942 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 increases expression ISO Deoxyglucose results in increased expression of SREBF1 mRNA CTD PMID:10913129 NCBI chr17:17,811,334...17,837,017
Ensembl chr17:17,810,399...17,837,011 		JBrowse link
G STK11 serine/threonine kinase 11 decreases phosphorylation EXP Deoxyglucose results in decreased phosphorylation of STK11 protein CTD PMID:23041229 NCBI chr19:1,205,778...1,228,431
Ensembl chr19:1,177,558...1,228,431
Ensembl chr19:1,177,558...1,228,431 		JBrowse link
G TNF tumor necrosis factor decreases expression
multiple interactions
decreases response to substance		 ISO
EXP		 Deoxyglucose results in decreased expression of TNF protein
Quercetin inhibits the reaction [TNF protein inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]]; TNF protein inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]
Deoxyglucose results in decreased susceptibility to TNF protein
Deoxyglucose inhibits the reaction [TNF protein results in increased expression of MMP13 protein]; TNF protein inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]; Troglitazone inhibits the reaction [TNF protein inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]]		 CTD PMID:16483873 PMID:21211511 PMID:21778228 PMID:22713545 PMID:23439570 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TP53 tumor protein p53 multiple interactions EXP [Deoxyglucose co-treated with demycarosyl-3D-digitoxosylmithramycin SK] results in increased expression of TP53 mRNA; Deoxyglucose promotes the reaction [demycarosyl-3D-digitoxosylmithramycin SK results in increased expression of TP53 mRNA]; TP53 protein inhibits the reaction [Deoxyglucose results in decreased abundance of Adenosine Triphosphate] CTD PMID:21042727 PMID:26079942 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G XIAP X-linked inhibitor of apoptosis multiple interactions EXP [arsenic trioxide co-treated with Deoxyglucose] results in decreased expression of XIAP protein CTD PMID:23041229 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,724...123,913,976
Ensembl chr  X:123,859,724...123,913,976 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24481
    role 24392
      biological role 24359
        biochemical role 23773
          metabolite 23696
            fundamental metabolite 13208
              glucose 2219
                D-glucose 2219
                  2-deoxy-D-glucose 78
                    2-deoxy-D-glucopyranose 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 24481
    subatomic particle 24438
      composite particle 24438
        hadron 24438
          baryon 24438
            nucleon 24438
              atomic nucleus 24438
                atom 24438
                  main group element atom 24295
                    p-block element atom 24295
                      carbon group element atom 24079
                        carbon atom 24040
                          organic molecular entity 24040
                            heteroorganic entity 23417
                              organochalcogen compound 22934
                                organooxygen compound 22776
                                  carbohydrates and carbohydrate derivatives 13082
                                    carbohydrate 13082
                                      monosaccharide 4334
                                        aldose 2640
                                          aldohexose 2259
                                            glucose 2219
                                              D-glucose 2219
                                                D-glucopyranose 1766
                                                  2-deoxy-D-glucose 78
                                                    2-deoxy-D-glucopyranose 0
paths to the root