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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:quinine
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Accession:CHEBI:15854 term browser browse the term
Definition:A cinchona alkaloid that is cinchonidine in which the hydrogen at the 6-position of the quinoline ring is substituted by methoxy.
Synonyms:exact_synonym: (9R)-6'-methoxy-8alpha-cinchonan-9-ol
 related_synonym: (8S,9R)-quinine;   (R)-(-)-quinine;   (R)-(6-methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methanol;   6'-methoxycinchonidine;   Chinin;   Formula=C20H24N2O2;   InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19-,20+/m0/s1;   InChIKey=LOUPRKONTZGTKE-WZBLMQSHSA-N;   SMILES=[H][C@]1(C[C@@H]2CC[N@]1C[C@@H]2C=C)[C@H](O)c1ccnc2ccc(OC)cc12;   chinine;   chininum;   quinina
 alt_id: CHEBI:127176;   CHEBI:15001;   CHEBI:26499;   CHEBI:355947;   CHEBI:569215;   CHEBI:602929;   CHEBI:8723
 xref: Beilstein:91867;   CAS:130-95-0;   DrugBank:DB00468;   Drug_Central:4523;   KEGG:C06526;   KEGG:D08460;   KNApSAcK:C00002193
 xref_mesh: MESH:D011803
 xref: PMID:10821711;   PMID:10891117;   PMID:10937718;   PMID:11212126;   PMID:11549443;   PMID:11728183;   PMID:11844668;   PMID:11855978;   PMID:12127529;   PMID:12213073;   PMID:12217353;   PMID:12477351;   PMID:12502361;   PMID:12798326;   PMID:12873511;   PMID:14761192;   PMID:15026051;   PMID:15027870;   PMID:15225721;   PMID:15857133;   PMID:16524728;   PMID:16933872;   PMID:17482816;   PMID:17506538;   PMID:17570664;   PMID:17850126;   PMID:18348514;   PMID:18788725;   PMID:2579237;   PMID:2657065;   PMID:7009867;   PMID:8182707;   Wikipedia:Quinine
 cyclic_relationship: is_conjugate_base_of CHEBI:137041



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quinine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects uptake ISO ABCB1 protein affects the uptake of Quinine analog CTD PMID:11934808 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects uptake EXP ABCB1B protein affects the uptake of Quinine analog CTD PMID:11934808 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Quinine affects the reaction [APP protein binds to APP protein] CTD PMID:18537544 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
decreases activity
increases expression
ISO Quinine results in increased activity of CYP1A1 protein
Quinine results in decreased activity of CYP1A1 protein
Quinine results in increased expression of CYP1A1 mRNA
CTD PMID:12451431 PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO Quinine results in increased expression of CYP1A2 mRNA CTD PMID:12451431 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity EXP Quinine results in decreased activity of CYP2C11 protein CTD PMID:12814958 PMID:15879494 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity EXP
ISO
Quinine results in decreased activity of CYP2C6V1 protein
Quinine results in decreased activity of CYP2C19 protein
CTD PMID:11124226 PMID:12814958 PMID:15879494 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 decreases activity
multiple interactions
EXP Quinine results in decreased activity of CYP2D2 protein
Quinine inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin]
CTD PMID:12814958 PMID:19858067 NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions EXP Quinine inhibits the reaction [CYP2D6 protein results in increased oxidation of Chlorpyrifos] CTD PMID:14979094 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
affects metabolic processing
ISO Quinine results in decreased activity of CYP3A4 protein
CYP3A4 protein affects the metabolism of Quinine
CTD PMID:11124226 PMID:12920490 PMID:15896247 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Grm1 glutamate metabotropic receptor 1 affects response to substance EXP GRM1 protein affects the susceptibility to Quinine CTD PMID:19174448 NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity ISO Quinine results in decreased activity of GSTM1 protein CTD PMID:11807801 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
decreases activity
ISO Quinine inhibits the reaction [GSTP1 protein affects the metabolism of and results in decreased activity of Ethacrynic Acid]
Quinine results in decreased activity of GSTP1 protein
CTD PMID:11807801 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Quinine CTD PMID:19362101 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Quinine CTD PMID:19362101 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects response to substance
decreases activity
ISO KCNH2 gene SNP affects the susceptibility to Quinine
Quinine results in decreased activity of KCNH2 protein
CTD PMID:12695533 PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kcnk18 potassium two pore domain channel subfamily K member 18 multiple interactions ISO Quinine inhibits the reaction [KCNK18 protein results in increased transport of Potassium] CTD PMID:12754259 NCBI chr 1:258,374,671...258,388,945
Ensembl chr 1:258,374,671...258,388,945
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions
increases uptake
decreases activity
EXP
ISO
Quinine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
SLC22A1 protein results in increased uptake of Quinine
[Quinine results in decreased activity of SLC22A1] which results in decreased uptake of abacavir; Quinine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]
Quinine results in decreased activity of SLC22A1; Quinine results in decreased activity of SLC22A1 protein
CTD PMID:16142924 PMID:16263091 PMID:19357179 PMID:25844889 PMID:27504015 More... NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions
decreases activity
ISO Quinine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Quinine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]
Quinine results in decreased activity of SLC22A2 protein
CTD PMID:16263091 PMID:19357179 PMID:21599003 PMID:27504015 PMID:31830554 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Quinine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium] CTD PMID:16263091 PMID:19357179 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Quinine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Quinine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
JBrowse link
G Slc9a7 solute carrier family 9 member A7 decreases activity ISO Quinine results in decreased activity of SLC9A7 protein CTD PMID:11279194 NCBI chr  X:2,214,064...2,395,052
Ensembl chr  X:2,214,441...2,388,012
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 decreases activity
increases uptake
multiple interactions
EXP
ISO
Quinine results in decreased activity of SLCO1A4 protein
SLCO1A2 protein results in increased uptake of Quinine
naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Quinine]; Quinine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]
Quinine inhibits the reaction [SLCO1A4 protein results in increased uptake of Digoxin]
CTD PMID:11883641 PMID:27504015 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Quinine
Quinine inhibits the reaction [TNF protein results in increased transport of Potassium]
CTD PMID:10783394 PMID:19362101 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
3-hydroxyquinine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects chemical synthesis ISO CYP3A4 protein affects the chemical synthesis of 3-hydroxyquinidine CTD PMID:15896247 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20050
    role 20001
      biological role 20000
        pharmacological role 19064
          analgesic 14635
            non-narcotic analgesic 13795
              quinine 25
                3-hydroxyquinine 1
                quinine sulfate + 0
                quininyl group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      carbon group element atom 19872
                        carbon atom 19863
                          organic molecular entity 19863
                            organic molecule 19809
                              organic cyclic compound 19572
                                organic heterocyclic compound 18799
                                  organonitrogen heterocyclic compound 17736
                                    quinolines 2621
                                      (8xi)-cinchonan 67
                                        (8S)-cinchonan 25
                                          quinine 25
                                            3-hydroxyquinine 1
                                            quinine sulfate + 0
                                            quininyl group 0
paths to the root