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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:juglone
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Accession:CHEBI:15794 term browser browse the term
Definition:A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogen at position 5 has been replaced by a hydroxy group. A plant-derived 1,4-naphthoquinone with confirmed antibacterial and antitumor activities.
Synonyms:related_synonym: 5-Hydroxy-1,4-naphthoquinone;   5-hydroxy-1,4-naphthalenedione;   8-hydroxy-1,4-naphthoquinone;   Formula=C10H6O3;   InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H;   InChIKey=KQPYUDDGWXQXHS-UHFFFAOYSA-N;   SMILES=Oc1cccc2C(=O)C=CC(=O)c12
 alt_id: CHEBI:12130;   CHEBI:20574;   CHEBI:2062
 xref: Beilstein:1909764;   CAS:481-39-0;   Gmelin:219094;   KEGG:C03840;   KNApSAcK:C00000144
 xref_mesh: MESH:C005134
 xref: PDBeChem:JUG;   PMID:19597959;   PMID:23163769;   PMID:27322260;   PMID:27600097;   PMID:27816681;   PMID:28069455;   PMID:28166217;   Reaxys:1909764


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juglone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO juglone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:19269596 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
increases expression		 ISO [Indomethacin co-treated with juglone] results in increased expression of BAD mRNA; [Indomethacin co-treated with juglone] results in increased expression of BAD protein; [juglone co-treated with Ascorbic Acid] results in increased expression of BAD protein
juglone results in increased expression of BAD mRNA; juglone results in increased expression of BAD protein		 CTD PMID:29992683 PMID:31916655 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO [Indomethacin co-treated with juglone] results in increased expression of BAX mRNA; [Indomethacin co-treated with juglone] results in increased expression of BAX protein; [juglone co-treated with Ascorbic Acid] results in increased expression of BAX protein
juglone results in increased expression of BAX mRNA; juglone results in increased expression of BAX protein		 CTD PMID:29992683 PMID:31916655 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression
multiple interactions		 ISO juglone results in increased expression of BBC3 protein
[Indomethacin co-treated with juglone] results in increased expression of BBC3 protein		 CTD PMID:31916655 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO [Indomethacin co-treated with juglone] results in decreased expression of BCL2 mRNA
juglone results in decreased expression of BCL2 mRNA		 CTD PMID:31916655 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [juglone co-treated with Ascorbic Acid] affects the expression of BID protein CTD PMID:29992683 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression		 ISO [Indomethacin co-treated with juglone] results in increased expression of CASP3 mRNA; [juglone co-treated with Ascorbic Acid] results in decreased expression of CASP3 protein
juglone results in increased expression of CASP3 mRNA		 CTD PMID:29992683 PMID:31916655 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity ISO juglone results in increased activity of CASP8 protein CTD PMID:20138029 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cat catalase multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in decreased activity of CAT protein CTD PMID:29992683 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions		 ISO juglone results in decreased expression of CCND1 mRNA; juglone results in decreased expression of CCND1 protein
[Indomethacin co-treated with juglone] results in decreased expression of CCND1 mRNA; [Indomethacin co-treated with juglone] results in decreased expression of CCND1 protein		 CTD PMID:31916655 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd3 cyclin D3 decreases expression
multiple interactions		 ISO juglone results in decreased expression of CCND3 protein
Ascorbic Acid promotes the reaction [juglone results in decreased expression of CCND3 protein]		 CTD PMID:29992683 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in decreased expression of CDK4 protein CTD PMID:29992683 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression		 ISO [Indomethacin co-treated with juglone] results in decreased expression of CTNNB1 mRNA; [Indomethacin co-treated with juglone] results in decreased expression of CTNNB1 protein
juglone results in decreased expression of CTNNB1 mRNA; juglone results in decreased expression of CTNNB1 protein		 CTD PMID:31916655 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO juglone results in increased expression of CYP1A1 mRNA CTD PMID:26558468 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Dab2 DAB adaptor protein 2 affects phosphorylation ISO juglone affects the phosphorylation of DAB2 protein CTD PMID:12881709 NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476 		JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) decreases activity ISO
EXP		 juglone results in decreased activity of DHODH protein CTD PMID:10658902 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654 		JBrowse link
G E2f4 E2F transcription factor 4 multiple interactions ISO juglone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of E2F4 protein] CTD PMID:20479004 NCBI chr19:33,174,396...33,181,806
Ensembl chr19:33,174,410...33,181,806 		JBrowse link
G Egr1 early growth response 1 multiple interactions ISO juglone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGR1 protein] CTD PMID:20479004 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in decreased activity of GSR protein CTD PMID:29992683 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 multiple interactions
decreases expression		 ISO [Indomethacin co-treated with juglone] results in decreased expression of HES1 mRNA; [Indomethacin co-treated with juglone] results in decreased expression of HES1 protein
juglone results in decreased expression of HES1 mRNA; juglone results in decreased expression of HES1 protein		 CTD PMID:31916655 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO juglone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MAP1LC3B protein] CTD PMID:20479004 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in decreased phosphorylation of MAPK1 protein CTD PMID:29992683 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in decreased phosphorylation of MAPK3 protein CTD PMID:29992683 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [juglone co-treated with Ascorbic Acid] affects the expression of MMP2 mRNA CTD PMID:29992683 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in decreased expression of MMP9 mRNA CTD PMID:29992683 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in increased degradation of PARP1 protein CTD PMID:29992683 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression
multiple interactions		 ISO juglone results in decreased expression of PCNA protein
[Indomethacin co-treated with juglone] results in decreased expression of PCNA protein		 CTD PMID:31916655 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 multiple interactions ISO juglone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIN1 mRNA]; juglone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIN1 protein]; juglone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PIN1 protein] CTD PMID:23754278 NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression		 ISO [Indomethacin co-treated with juglone] results in increased expression of PPARG mRNA; [Indomethacin co-treated with juglone] results in increased expression of PPARG protein
juglone results in increased expression of PPARG mRNA; juglone results in increased expression of PPARG protein		 CTD PMID:31916655 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression		 ISO [Indomethacin co-treated with juglone] results in decreased expression of PTGS2 mRNA; [Indomethacin co-treated with juglone] results in decreased expression of PTGS2 protein; [juglone co-treated with Ascorbic Acid] results in decreased expression of PTGS2 mRNA
juglone results in decreased expression of PTGS2 mRNA; juglone results in decreased expression of PTGS2 protein		 CTD PMID:29992683 PMID:31916655 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO juglone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] CTD PMID:23754278 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO [juglone co-treated with Ascorbic Acid] affects the expression of TIMP1 mRNA CTD PMID:29992683 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO juglone results in increased expression of TIMP2 mRNA CTD PMID:29992683 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO [Indomethacin co-treated with juglone] results in decreased expression of TNF mRNA; [Indomethacin co-treated with juglone] results in decreased expression of TNF protein
juglone results in decreased expression of TNF mRNA; juglone results in decreased expression of TNF protein		 CTD PMID:31916655 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in increased phosphorylation of TP53 protein CTD PMID:29992683 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases reduction ISO TXNRD1 protein results in increased reduction of juglone CTD PMID:21172426 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Txnrd2 thioredoxin reductase 2 increases reduction ISO TXNRD2 protein results in increased reduction of juglone CTD PMID:21172426 NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [juglone co-treated with Ascorbic Acid] results in decreased expression of VEGFA mRNA CTD PMID:29992683 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
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  CHEBI ontology 19921
    role 19893
      chemical role 19524
        reactive oxygen species generator 950
          juglone 38
Path 2
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  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    p-block element atom 19865
                      carbon group element atom 19804
                        carbon atom 19801
                          organic molecular entity 19801
                            heteroorganic entity 19558
                              organochalcogen compound 19317
                                organooxygen compound 19233
                                  carbonyl compound 18951
                                    ketone 17197
                                      cyclic ketone 15714
                                        quinone 8652
                                          naphthoquinone 1475
                                            1,4-naphthoquinones 1463
                                              hydroxy-1,4-naphthoquinone 157
                                                juglone 38
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