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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dichloromethane
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Accession:CHEBI:15767 term browser browse the term
Definition:A member of the class of chloromethanes that is methane in which two of the hydrogens have been replaced by chlorine. A dense, non-flammible colourless liquid at room temperature (b.p. 40degreeC, d = 1.33) which is immiscible with water, it is widely used as a solvent, a paint stripper, and for the removal of caffeine from coffee and tea.
Synonyms:related_synonym: DCM;   Dichlormethan;   Formula=CH2Cl2;   InChI=1S/CH2Cl2/c2-1-3/h1H2;   InChIKey=YMWUJEATGCHHMB-UHFFFAOYSA-N;   Methylenchlorid;   Methylene chloride;   Methylene dichloride;   SMILES=[H]C([H])(Cl)Cl;   chlorure de methylene;   methane dichloride;   methylene bichloride
 alt_id: CHEBI:14139;   CHEBI:23701;   CHEBI:4504
 xref: Beilstein:1730800;   CAS:75-09-2;   Gmelin:1302;   HMDB:HMDB0031548;   KEGG:C02271;   KEGG:D02330
 xref_mesh: MESH:D008752
 xref: MetaCyc:CPD-681;   PMID:11884241;   PMID:19091298;   PMID:8465711;   Patent:US2792435;   Patent:US2979541;   Patent:US3126419;   Reaxys:1730800;   UM-BBD_compID:c0233;   Wikipedia:Dichloromethane


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dichloromethane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 multiple interactions EXP [Particulate Matter co-treated with Methylene Chloride] results in decreased expression of ADRB1 mRNA CTD PMID:30503853 NCBI chr10:114,043,866...114,046,904
Ensembl chr10:114,043,866...114,046,904 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which affects the expression of AKT1 mRNA CTD PMID:29335169 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G AR androgen receptor decreases expression ISO Methylene Chloride results in decreased expression of AR mRNA CTD PMID:28392392 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G ATF5 activating transcription factor 5 decreases expression ISO Methylene Chloride results in decreased expression of ATF5 mRNA CTD PMID:28392392 NCBI chr19:49,928,906...49,933,935
Ensembl chr19:49,928,702...49,933,935 		JBrowse link
G BACH2 BTB domain and CNC homolog 2 decreases expression ISO Methylene Chloride results in decreased expression of BACH2 mRNA CTD PMID:28392392 NCBI chr 6:89,926,528...90,296,843
Ensembl chr 6:89,926,528...90,296,843 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which affects the expression of BCL2 mRNA CTD PMID:29335169 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2A1 BCL2 related protein A1 increases expression EXP Methylene Chloride results in increased expression of BCL2A1 mRNA CTD PMID:20359517 NCBI chr15:79,960,892...79,971,196
Ensembl chr15:79,960,892...79,971,196 		JBrowse link
G BCL6 BCL6 transcription repressor increases expression EXP
ISO		 Methylene Chloride results in increased expression of BCL6 mRNA CTD PMID:20359517 PMID:28392392 NCBI chr 3:187,721,377...187,745,468
Ensembl chr 3:187,721,377...187,745,725 		JBrowse link
G BHLHE40 basic helix-loop-helix family member e40 increases expression ISO Methylene Chloride results in increased expression of BHLHE40 mRNA CTD PMID:28392392 NCBI chr 3:4,979,437...4,985,323
Ensembl chr 3:4,979,437...4,985,323 		JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 increases expression EXP Methylene Chloride results in increased expression of BIRC3 mRNA CTD PMID:20359517 NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403 		JBrowse link
G BMAL1 basic helix-loop-helix ARNT like 1 decreases expression ISO Methylene Chloride results in decreased expression of BMAL1 mRNA CTD PMID:28392392 NCBI chr11:13,276,652...13,387,266
Ensembl chr11:13,276,652...13,387,266 		JBrowse link
G BNC1 basonuclin zinc finger protein 1 decreases expression ISO Methylene Chloride results in decreased expression of BNC1 mRNA CTD PMID:28392392 NCBI chr15:83,255,884...83,284,664
Ensembl chr15:83,255,884...83,284,664 		JBrowse link
G BTG1 BTG anti-proliferation factor 1 increases expression EXP Methylene Chloride results in increased expression of BTG1 mRNA CTD PMID:20359517 NCBI chr12:92,140,278...92,145,846
Ensembl chr12:92,140,278...92,145,846 		JBrowse link
G CASP1 caspase 1 multiple interactions ISO [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in increased expression of CASP1 mRNA CTD PMID:29335169 NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250 		JBrowse link
G CASP3 caspase 3 multiple interactions ISO [Methylene Chloride co-treated with Biliverdine] inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of CASP3 protein]; Methylene Chloride inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of CASP3 protein] CTD PMID:15486963 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CAT catalase multiple interactions ISO [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in decreased expression of CAT mRNA; [Lipopolysaccharides co-treated with Methylene Chloride] results in increased activity of CAT protein CTD PMID:15563889 PMID:29335169 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CBLB Cbl proto-oncogene B increases expression ISO Methylene Chloride results in increased expression of CBLB mRNA CTD PMID:20955722 NCBI chr 3:105,655,461...105,869,449
Ensembl chr 3:105,655,461...105,869,552 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 decreases expression ISO Methylene Chloride results in decreased expression of CCL5 mRNA CTD PMID:20955722 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793 		JBrowse link
G CD37 CD37 molecule decreases expression ISO Methylene Chloride results in decreased expression of CD37 mRNA CTD PMID:20955722 NCBI chr19:49,335,406...49,340,606
Ensembl chr19:49,335,171...49,343,335 		JBrowse link
G CD38 CD38 molecule increases expression ISO Methylene Chloride results in increased expression of CD38 mRNA CTD PMID:20955722 NCBI chr 4:15,778,328...15,853,232
Ensembl chr 4:15,778,275...15,853,232 		JBrowse link
G CD4 CD4 molecule increases expression ISO Methylene Chloride results in increased expression of CD4 mRNA CTD PMID:20955722 NCBI chr12:6,789,528...6,820,799
Ensembl chr12:6,786,858...6,820,799 		JBrowse link
G CD8A CD8 subunit alpha increases expression ISO Methylene Chloride results in increased expression of CD8A mRNA CTD PMID:20955722 NCBI chr 2:86,784,605...86,808,396
Ensembl chr 2:86,784,610...86,808,396 		JBrowse link
G CDH1 cadherin 1 affects expression EXP Methylene Chloride affects the expression of CDH1 mRNA CTD PMID:34280354 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537 		JBrowse link
G CEBPB CCAAT enhancer binding protein beta increases expression ISO Methylene Chloride results in increased expression of CEBPB mRNA CTD PMID:28392392 NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,830...50,192,668 		JBrowse link
G CIITA class II major histocompatibility complex transactivator increases expression ISO Methylene Chloride results in increased expression of CIITA mRNA CTD PMID:20955722 NCBI chr16:10,866,206...10,943,021
Ensembl chr16:10,866,222...10,943,021 		JBrowse link
G CLOCK clock circadian regulator decreases expression ISO Methylene Chloride results in decreased expression of CLOCK mRNA CTD PMID:28392392 NCBI chr 4:55,427,903...55,546,909
Ensembl chr 4:55,427,903...55,546,909 		JBrowse link
G CREB3L1 cAMP responsive element binding protein 3 like 1 decreases expression ISO Methylene Chloride results in decreased expression of CREB3L1 mRNA CTD PMID:28392392 NCBI chr11:46,277,662...46,321,409
Ensembl chr11:46,277,662...46,321,409 		JBrowse link
G CREB3L2 cAMP responsive element binding protein 3 like 2 decreases expression ISO Methylene Chloride results in decreased expression of CREB3L2 mRNA CTD PMID:28392392 NCBI chr 7:137,874,979...138,002,086
Ensembl chr 7:137,874,979...138,002,086 		JBrowse link
G CREM cAMP responsive element modulator decreases expression ISO Methylene Chloride results in decreased expression of CREM mRNA CTD PMID:28392392 NCBI chr10:35,126,846...35,212,958
Ensembl chr10:35,126,791...35,212,958 		JBrowse link
G CRY1 cryptochrome circadian regulator 1 decreases expression ISO Methylene Chloride results in decreased expression of CRY1 mRNA CTD PMID:28392392 NCBI chr12:106,991,364...107,093,549
Ensembl chr12:106,991,364...107,093,549 		JBrowse link
G CRY2 cryptochrome circadian regulator 2 increases expression ISO Methylene Chloride results in increased expression of CRY2 mRNA CTD PMID:28392392 NCBI chr11:45,847,118...45,883,244
Ensembl chr11:45,847,118...45,883,248 		JBrowse link
G CSDE1 cold shock domain containing E1 increases expression ISO Methylene Chloride results in increased expression of CSDE1 mRNA CTD PMID:28392392 NCBI chr 1:114,716,916...114,757,984
Ensembl chr 1:114,716,913...114,758,676 		JBrowse link
G CTH cystathionine gamma-lyase increases expression EXP Methylene Chloride results in increased expression of CTH mRNA CTD PMID:20359517 NCBI chr 1:70,411,268...70,439,851
Ensembl chr 1:70,411,218...70,439,851 		JBrowse link
G CTNNB1 catenin beta 1 increases mutagenesis ISO Methylene Chloride results in increased mutagenesis of CTNNB1 gene CTD PMID:10467420 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096 		JBrowse link
G CUX1 cut like homeobox 1 decreases expression ISO Methylene Chloride results in decreased expression of CUX1 mRNA CTD PMID:28392392 NCBI chr 7:101,816,007...102,283,958
Ensembl chr 7:101,815,904...102,283,958 		JBrowse link
G CUX2 cut like homeobox 2 decreases expression ISO Methylene Chloride results in decreased expression of CUX2 mRNA CTD PMID:28392392 NCBI chr12:111,034,165...111,350,554
Ensembl chr12:111,034,165...111,350,554 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression
multiple interactions		 EXP Methylene Chloride results in increased expression of CXCL8 mRNA
[Particulate Matter co-treated with Methylene Chloride] results in increased expression of CXCL8 mRNA; carazolol inhibits the reaction [[Particulate Matter co-treated with Methylene Chloride] results in increased expression of CXCL8 mRNA]		 CTD PMID:20359517 PMID:30503853 PMID:34280354 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 increases expression ISO Methylene Chloride results in increased expression of CXCR2 mRNA CTD PMID:20955722 NCBI chr 2:218,125,294...218,137,251
Ensembl chr 2:218,125,289...218,137,251 		JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 increases expression EXP Methylene Chloride results in increased expression of CXCR4 mRNA CTD PMID:20359517 NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,119,177 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions ISO [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in increased expression of CYP1A1 mRNA CTD PMID:29335169 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 affects expression ISO Methylene Chloride affects the expression of CYP1A2 mRNA CTD PMID:28392392 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases expression EXP Methylene Chloride results in decreased expression of CYP1B1 mRNA CTD PMID:20359517 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 affects expression ISO Methylene Chloride affects the expression of CYP2C29 mRNA CTD PMID:28392392 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions
increases oxidation
increases metabolic processing		 ISO
EXP		 3-xylene promotes the reaction [CYP2E1 protein results in increased metabolism of Methylene Chloride]; Benzene promotes the reaction [CYP2E1 protein results in increased metabolism of Methylene Chloride]; Toluene promotes the reaction [CYP2E1 protein results in increased metabolism of Methylene Chloride]
[[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in increased expression of CYP2E1 mRNA
CYP2E1 protein results in increased oxidation of Methylene Chloride		 CTD PMID:1664256 PMID:8889796 PMID:29335169 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G CYP51A1 cytochrome P450 family 51 subfamily A member 1 affects expression ISO Methylene Chloride affects the expression of CYP51 mRNA CTD PMID:28392392 NCBI chr 7:92,112,153...92,134,803
Ensembl chr 7:92,084,987...92,134,803 		JBrowse link
G DAPK1 death associated protein kinase 1 increases methylation EXP Methylene Chloride results in increased methylation of DAPK1 promoter CTD PMID:15172992 NCBI chr 9:87,497,228...87,708,634
Ensembl chr 9:87,497,228...87,708,634 		JBrowse link
G DBP D-box binding PAR bZIP transcription factor increases expression ISO Methylene Chloride results in increased expression of DBP mRNA CTD PMID:28392392 NCBI chr19:48,630,030...48,637,379
Ensembl chr19:48,630,030...48,637,379 		JBrowse link
G DENND5A DENN domain containing 5A increases expression EXP Methylene Chloride results in increased expression of DENND5A mRNA CTD PMID:20359517 NCBI chr11:9,138,825...9,265,350
Ensembl chr11:9,138,825...9,265,959 		JBrowse link
G DHCR24 24-dehydrocholesterol reductase affects expression ISO Methylene Chloride affects the expression of DHCR24 mRNA CTD PMID:28392392 NCBI chr 1:54,849,627...54,887,195
Ensembl chr 1:54,849,627...54,887,195 		JBrowse link
G DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 increases expression EXP Methylene Chloride results in increased expression of DNAJB9 mRNA CTD PMID:20359517 NCBI chr 7:108,569,874...108,574,850
Ensembl chr 7:108,569,867...108,574,850 		JBrowse link
G EBP EBP cholestenol delta-isomerase affects expression ISO Methylene Chloride affects the expression of EBP mRNA CTD PMID:28392392 NCBI chr  X:48,521,808...48,528,716
Ensembl chr  X:48,521,799...48,528,716 		JBrowse link
G EGR1 early growth response 1 affects expression ISO Methylene Chloride affects the expression of EGR1 mRNA CTD PMID:28392392 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303 		JBrowse link
G EGR3 early growth response 3 increases expression EXP Methylene Chloride results in increased expression of EGR3 mRNA CTD PMID:20359517 NCBI chr 8:22,687,659...22,693,480
Ensembl chr 8:22,687,659...22,693,480 		JBrowse link
G ELF1 E74 like ETS transcription factor 1 decreases expression ISO Methylene Chloride results in decreased expression of ELF1 mRNA CTD PMID:28392392 NCBI chr13:40,931,919...41,061,386
Ensembl chr13:40,931,924...41,061,440 		JBrowse link
G ELOVL6 ELOVL fatty acid elongase 6 increases expression EXP Methylene Chloride results in increased expression of ELOVL6 mRNA CTD PMID:20359517 NCBI chr 4:110,045,846...110,199,202
Ensembl chr 4:110,045,846...110,199,199 		JBrowse link
G ESR1 estrogen receptor 1 decreases expression ISO Methylene Chloride results in decreased expression of ESR1 mRNA CTD PMID:28392392 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G EVI2A ecotropic viral integration site 2A increases expression EXP Methylene Chloride results in increased expression of EVI2A mRNA CTD PMID:20359517 NCBI chr17:31,316,410...31,321,622
Ensembl chr17:31,316,410...31,321,749 		JBrowse link
G FCGR1A Fc gamma receptor Ia increases expression ISO Methylene Chloride results in increased expression of FCGR1 mRNA CTD PMID:20955722 NCBI chr 1:149,782,694...149,800,609
Ensembl chr 1:149,782,671...149,791,675 		JBrowse link
G FDFT1 farnesyl-diphosphate farnesyltransferase 1 affects expression ISO Methylene Chloride affects the expression of FDFT1 mRNA CTD PMID:28392392 NCBI chr 8:11,795,582...11,839,309
Ensembl chr 8:11,795,573...11,839,395 		JBrowse link
G FDPS farnesyl diphosphate synthase affects expression ISO Methylene Chloride affects the expression of FDPS mRNA CTD PMID:28392392 NCBI chr 1:155,308,866...155,320,665
Ensembl chr 1:155,308,748...155,320,666 		JBrowse link
G FILIP1L filamin A interacting protein 1 like increases expression EXP Methylene Chloride results in increased expression of FILIP1L mRNA CTD PMID:20359517 NCBI chr 3:99,828,811...100,114,501
Ensembl chr 3:99,828,811...100,114,513 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Methylene Chloride results in decreased expression of FOS mRNA CTD PMID:28392392 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G FOXA1 forkhead box A1 decreases expression ISO Methylene Chloride results in decreased expression of FOXA1 mRNA CTD PMID:28392392 NCBI chr14:37,589,552...37,595,249
Ensembl chr14:37,589,552...37,596,059 		JBrowse link
G FOXO3 forkhead box O3 increases expression ISO Methylene Chloride results in increased expression of FOXO3 mRNA CTD PMID:28392392 NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774 		JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha increases expression EXP Methylene Chloride results in increased expression of GADD45A mRNA CTD PMID:20359517 NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions ISO [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in decreased expression of GCLC mRNA CTD PMID:29335169 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970 		JBrowse link
G GP1BB glycoprotein Ib platelet subunit beta decreases expression ISO Methylene Chloride results in decreased expression of GP1BB mRNA CTD PMID:20955722 NCBI chr22:19,723,539...19,724,771
Ensembl chr22:19,723,539...19,724,771 		JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions ISO [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which affects the expression of GPX1 mRNA CTD PMID:29335169 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605 		JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO [Lipopolysaccharides co-treated with Methylene Chloride] results in increased activity of GSR protein CTD PMID:15563889 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G GSTT1 glutathione S-transferase theta 1 affects metabolic processing
multiple interactions
increases metabolic processing
affects response to substance		 EXP
ISO		 GSTT1 gene polymorphism affects the metabolism of Methylene Chloride; GSTT1 protein affects the metabolism of Methylene Chloride
GSTT1 protein results in increased metabolism of and results in increased activity of Methylene Chloride
GSTT1 protein results in increased metabolism of Methylene Chloride
[GSTT1 protein affects the metabolism of Methylene Chloride] which results in increased abundance of Formaldehyde; GSTT1 protein affects the metabolism of and results in increased activity of Methylene Chloride
GSTT1 protein alternative form affects the susceptibility to Methylene Chloride		 CTD PMID:7979958 PMID:8670055 PMID:8761485 PMID:9854036 PMID:10413528 More...
G HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 decreases expression ISO Methylene Chloride results in decreased expression of HERC1 mRNA CTD PMID:20955722 NCBI chr15:63,608,618...63,833,948
Ensembl chr15:63,608,618...63,833,948 		JBrowse link
G HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 increases expression EXP Methylene Chloride results in increased expression of HERC5 mRNA CTD PMID:20359517 NCBI chr 4:88,457,119...88,506,163
Ensembl chr 4:88,457,119...88,506,163 		JBrowse link
G HES6 hes family bHLH transcription factor 6 increases expression ISO Methylene Chloride results in increased expression of HES6 mRNA CTD PMID:28392392 NCBI chr 2:238,238,267...238,240,038
Ensembl chr 2:238,238,267...238,240,662 		JBrowse link
G HIVEP2 HIVEP zinc finger 2 increases expression EXP Methylene Chloride results in increased expression of HIVEP2 mRNA CTD PMID:20359517 NCBI chr 6:142,751,469...142,946,365
Ensembl chr 6:142,751,469...142,956,698 		JBrowse link
G HLA-DMB major histocompatibility complex, class II, DM beta increases expression ISO Methylene Chloride results in increased expression of HLA-DMB mRNA CTD PMID:20955722 NCBI chr 6:32,934,636...32,941,028
Ensembl chr 6:32,934,629...32,941,028 		JBrowse link
G HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 increases expression ISO Methylene Chloride results in increased expression of RT1-BA mRNA CTD PMID:20955722 NCBI chr 6:32,637,406...32,655,272
Ensembl chr 6:32,628,179...32,647,062 		JBrowse link
G HLA-DRB1 major histocompatibility complex, class II, DR beta 1 increases expression ISO Methylene Chloride results in increased expression of RT1-DB1 mRNA CTD PMID:20955722 NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,577,902...32,589,848 		JBrowse link
G HLF HLF transcription factor, PAR bZIP family member increases expression ISO Methylene Chloride results in increased expression of HLF mRNA CTD PMID:28392392 NCBI chr17:55,264,960...55,325,187
Ensembl chr17:55,264,960...55,325,187 		JBrowse link
G HMOX1 heme oxygenase 1 increases expression
multiple interactions		 EXP
ISO		 Methylene Chloride results in increased expression of HMOX1 mRNA
[[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which affects the expression of HMOX1 mRNA
[Particulate Matter co-treated with Methylene Chloride] results in increased expression of HMOX1 mRNA		 CTD PMID:20359517 PMID:29335169 PMID:30503853 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HNRNPLL heterogeneous nuclear ribonucleoprotein L like increases expression EXP Methylene Chloride results in increased expression of HNRNPLL mRNA CTD PMID:20359517 NCBI chr 2:38,561,969...38,602,928
Ensembl chr 2:38,561,969...38,603,586 		JBrowse link
G HSD17B7 hydroxysteroid 17-beta dehydrogenase 7 affects expression ISO Methylene Chloride affects the expression of HSD17B7 mRNA CTD PMID:28392392 NCBI chr 1:162,790,702...162,812,823
Ensembl chr 1:162,790,702...162,812,823 		JBrowse link
G ID3 inhibitor of DNA binding 3 decreases expression ISO Methylene Chloride results in decreased expression of ID3 mRNA CTD PMID:28392392 NCBI chr 1:23,557,926...23,559,501
Ensembl chr 1:23,557,926...23,559,501 		JBrowse link
G IDI1 isopentenyl-diphosphate delta isomerase 1 affects expression ISO Methylene Chloride affects the expression of IDI1 mRNA CTD PMID:28392392 NCBI chr10:1,039,152...1,056,704
Ensembl chr10:1,039,152...1,049,119 		JBrowse link
G IFIT1 interferon induced protein with tetratricopeptide repeats 1 increases expression EXP Methylene Chloride results in increased expression of IFIT1 mRNA CTD PMID:20359517 NCBI chr10:89,392,623...89,406,487
Ensembl chr10:89,392,546...89,406,487 		JBrowse link
G IFIT2 interferon induced protein with tetratricopeptide repeats 2 increases expression EXP Methylene Chloride results in increased expression of IFIT2 mRNA CTD PMID:20359517 NCBI chr10:89,302,046...89,309,271
Ensembl chr10:89,283,694...89,309,271 		JBrowse link
G IFIT3 interferon induced protein with tetratricopeptide repeats 3 increases expression EXP Methylene Chloride results in increased expression of IFIT3 mRNA CTD PMID:20359517 NCBI chr10:89,327,997...89,340,968
Ensembl chr10:89,327,307...89,377,473 		JBrowse link
G IFNG interferon gamma multiple interactions ISO [Methylene Chloride co-treated with Biliverdine] inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IFNG protein] CTD PMID:15486963 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IFNGR2 interferon gamma receptor 2 increases expression EXP Methylene Chloride results in increased expression of IFNGR2 mRNA CTD PMID:20359517 NCBI chr21:33,402,882...33,437,516
Ensembl chr21:33,403,413...33,479,348 		JBrowse link
G IL10 interleukin 10 multiple interactions ISO [Methylene Chloride co-treated with Biliverdine] inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL10 protein] CTD PMID:15486963 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL1A interleukin 1 alpha multiple interactions EXP [Particulate Matter co-treated with Methylene Chloride] results in increased expression of IL1A mRNA CTD PMID:30503853 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493 		JBrowse link
G IL1RN interleukin 1 receptor antagonist multiple interactions ISO [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in increased expression of IL1RN mRNA CTD PMID:29335169 NCBI chr 2:113,099,360...113,134,014
Ensembl chr 2:113,099,315...113,134,016 		JBrowse link
G IL2RG interleukin 2 receptor subunit gamma increases expression ISO Methylene Chloride results in increased expression of IL2RG mRNA CTD PMID:20955722 NCBI chr  X:71,107,404...71,111,577
Ensembl chr  X:71,107,404...71,112,108 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO [Methylene Chloride co-treated with Biliverdine] inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL6 protein] CTD PMID:15486963 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G IL7R interleukin 7 receptor decreases expression ISO Methylene Chloride results in decreased expression of IL7R mRNA CTD PMID:20955722 NCBI chr 5:35,856,891...35,879,603
Ensembl chr 5:35,852,695...35,879,603 		JBrowse link
G IL9 interleukin 9 increases expression ISO Methylene Chloride results in increased expression of IL9 mRNA CTD PMID:20955722 NCBI chr 5:135,892,246...135,895,841
Ensembl chr 5:135,892,246...135,895,841 		JBrowse link
G IRF5 interferon regulatory factor 5 decreases expression ISO Methylene Chloride results in decreased expression of IRF5 mRNA CTD PMID:28392392 NCBI chr 7:128,937,032...128,950,038
Ensembl chr 7:128,937,457...128,950,038 		JBrowse link
G IRF6 interferon regulatory factor 6 decreases expression ISO Methylene Chloride results in decreased expression of IRF6 mRNA CTD PMID:28392392 NCBI chr 1:209,785,617...209,806,142
Ensembl chr 1:209,785,617...209,806,175 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Methylene Chloride results in increased expression of JUN mRNA CTD PMID:28392392 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Methylene Chloride results in increased expression of JUNB mRNA CTD PMID:28392392 NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315 		JBrowse link
G KLF13 KLF transcription factor 13 decreases expression ISO Methylene Chloride results in decreased expression of KLF13 mRNA CTD PMID:28392392 NCBI chr15:31,326,835...31,435,665
Ensembl chr15:31,326,835...31,435,665 		JBrowse link
G LSS lanosterol synthase affects expression ISO Methylene Chloride affects the expression of LSS mRNA CTD PMID:28392392 NCBI chr21:46,188,446...46,228,774
Ensembl chr21:46,188,141...46,228,824 		JBrowse link
G MAFB MAF bZIP transcription factor B increases expression ISO Methylene Chloride results in increased expression of MAFB mRNA CTD PMID:28392392 NCBI chr20:40,685,848...40,689,236
Ensembl chr20:40,685,848...40,689,236 		JBrowse link
G MAP3K8 mitogen-activated protein kinase kinase kinase 8 increases expression EXP Methylene Chloride results in increased expression of MAP3K8 mRNA CTD PMID:20359517 NCBI chr10:30,434,021...30,461,833
Ensembl chr10:30,434,021...30,461,833 		JBrowse link
G MGST1 microsomal glutathione S-transferase 1 multiple interactions ISO [propylene dichloride co-treated with Methylene Chloride] affects the activity of and affects the expression of MGST1 protein; Methylene Chloride affects the activity of and affects the expression of MGST1 protein CTD PMID:30240022 NCBI chr12:16,347,115...16,593,331
Ensembl chr12:16,347,142...16,609,259 		JBrowse link
G MMP1 matrix metallopeptidase 1 multiple interactions EXP [Particulate Matter co-treated with Methylene Chloride] results in increased expression of MMP1 mRNA; carazolol inhibits the reaction [[Particulate Matter co-treated with Methylene Chloride] results in increased expression of MMP1 mRNA] CTD PMID:30503853 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160 		JBrowse link
G MMP9 matrix metallopeptidase 9 increases expression EXP Methylene Chloride results in increased expression of MMP9 mRNA CTD PMID:34280354 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MT-CO1 mitochondrially encoded cytochrome c oxidase I decreases expression
multiple interactions		 ISO Methylene Chloride results in decreased expression of COX1 protein
[propylene dichloride co-treated with Methylene Chloride] affects the expression of COX1 protein		 CTD PMID:30240022 NCBI chr MT:5,904...7,445
Ensembl chr MT:5,904...7,445 		JBrowse link
G MT2A metallothionein 2A multiple interactions ISO [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which affects the expression of MT2 mRNA CTD PMID:29335169 NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497 		JBrowse link
G MVD mevalonate diphosphate decarboxylase affects expression ISO Methylene Chloride affects the expression of MVD mRNA CTD PMID:28392392 NCBI chr16:88,651,940...88,663,091
Ensembl chr16:88,651,935...88,663,161 		JBrowse link
G MVK mevalonate kinase affects expression ISO Methylene Chloride affects the expression of MVK mRNA CTD PMID:28392392 NCBI chr12:109,573,272...109,598,125
Ensembl chr12:109,573,255...109,598,125 		JBrowse link
G MXD1 MAX dimerization protein 1 increases expression EXP Methylene Chloride results in increased expression of MXD1 mRNA CTD PMID:20359517 NCBI chr 2:69,915,109...69,942,945
Ensembl chr 2:69,897,688...69,942,945 		JBrowse link
G MYSM1 Myb like, SWIRM and MPN domains 1 decreases expression ISO Methylene Chloride results in decreased expression of MYSM1 mRNA CTD PMID:28392392 NCBI chr 1:58,654,743...58,700,062
Ensembl chr 1:58,643,440...58,700,090 		JBrowse link
G NAMPT nicotinamide phosphoribosyltransferase decreases expression ISO Methylene Chloride results in decreased expression of NAMPT mRNA CTD PMID:28392392 NCBI chr 7:106,248,298...106,285,888
Ensembl chr 7:106,248,298...106,285,966 		JBrowse link
G NCAM1 neural cell adhesion molecule 1 decreases expression ISO Methylene Chloride results in decreased expression of NCAM1 mRNA CTD PMID:20955722 NCBI chr11:112,961,420...113,278,436
Ensembl chr11:112,961,275...113,278,436 		JBrowse link
G NCF2 neutrophil cytosolic factor 2 increases expression EXP Methylene Chloride results in increased expression of NCF2 mRNA CTD PMID:20359517 NCBI chr 1:183,555,562...183,601,849
Ensembl chr 1:183,554,461...183,590,905 		JBrowse link
G NCOR1 nuclear receptor corepressor 1 decreases expression ISO Methylene Chloride results in decreased expression of NCOR1 mRNA CTD PMID:28392392 NCBI chr17:16,029,157...16,215,534
Ensembl chr17:16,029,065...16,218,185 		JBrowse link
G NDUFB8 NADH:ubiquinone oxidoreductase subunit B8 increases expression ISO Methylene Chloride results in increased expression of NDUFB8 protein CTD PMID:30240022 NCBI chr10:100,523,729...100,529,923
Ensembl chr10:100,523,740...100,530,000 		JBrowse link
G NDUFS3 NADH:ubiquinone oxidoreductase core subunit S3 affects expression
multiple interactions		 ISO Methylene Chloride affects the expression of NDUFS3 protein
[propylene dichloride co-treated with Methylene Chloride] results in decreased expression of NDUFS3 protein		 CTD PMID:30240022 NCBI chr11:47,579,074...47,584,562
Ensembl chr11:47,565,336...47,584,562 		JBrowse link
G NECTIN3 nectin cell adhesion molecule 3 decreases expression ISO Methylene Chloride results in decreased expression of NECTIN3 mRNA CTD PMID:20955722 NCBI chr 3:111,071,816...111,194,170
Ensembl chr 3:111,070,071...111,275,563 		JBrowse link
G NEDD9 neural precursor cell expressed, developmentally down-regulated 9 increases expression EXP Methylene Chloride results in increased expression of NEDD9 mRNA CTD PMID:20359517 NCBI chr 6:11,183,298...11,382,348
Ensembl chr 6:11,183,298...11,382,348 		JBrowse link
G NFAT5 nuclear factor of activated T cells 5 increases expression EXP Methylene Chloride results in increased expression of NFAT5 mRNA CTD PMID:20359517 NCBI chr16:69,565,966...69,704,654
Ensembl chr16:69,565,094...69,704,666 		JBrowse link
G NFATC3 nuclear factor of activated T cells 3 decreases expression ISO Methylene Chloride results in decreased expression of NFATC3 mRNA CTD PMID:20955722 NCBI chr16:68,085,370...68,229,259
Ensembl chr16:68,084,751...68,229,259 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 increases activity
increases expression
multiple interactions		 ISO
EXP		 Methylene Chloride results in increased activity of NFE2L2 protein
Methylene Chloride results in increased expression of NFE2L2 mRNA
[[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which affects the expression of NFE2L2 mRNA		 CTD PMID:29335169 PMID:30114225 PMID:30203046 PMID:34280354 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFIB nuclear factor I B increases expression EXP Methylene Chloride results in increased expression of NFIB mRNA CTD PMID:20359517 NCBI chr 9:14,081,843...14,532,077
Ensembl chr 9:14,081,843...14,398,983 		JBrowse link
G NFIL3 nuclear factor, interleukin 3 regulated decreases expression ISO Methylene Chloride results in decreased expression of NFIL3 mRNA CTD PMID:28392392 NCBI chr 9:91,409,045...91,483,497
Ensembl chr 9:91,409,045...91,423,832 		JBrowse link
G NFKBIA NFKB inhibitor alpha increases expression EXP Methylene Chloride results in increased expression of NFKBIA mRNA CTD PMID:20359517 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in increased expression of NOS2 mRNA; Methylene Chloride inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Methylene Chloride inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:15563889 PMID:29335169 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NPAS2 neuronal PAS domain protein 2 decreases expression ISO Methylene Chloride results in decreased expression of NPAS2 mRNA CTD PMID:28392392 NCBI chr 2:100,818,723...100,996,829
Ensembl chr 2:100,820,139...100,996,829 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which affects the expression of NQO1 mRNA CTD PMID:29335169 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G NR1D1 nuclear receptor subfamily 1 group D member 1 increases expression ISO Methylene Chloride results in increased expression of NR1D1 mRNA CTD PMID:28392392 NCBI chr17:40,092,793...40,100,589
Ensembl chr17:40,092,793...40,100,589 		JBrowse link
G NR1D2 nuclear receptor subfamily 1 group D member 2 increases expression ISO Methylene Chloride results in increased expression of NR1D2 mRNA CTD PMID:28392392 NCBI chr 3:23,945,286...23,980,617
Ensembl chr 3:23,945,286...23,980,617 		JBrowse link
G NR2F6 nuclear receptor subfamily 2 group F member 6 increases expression ISO Methylene Chloride results in increased expression of NR2F6 mRNA CTD PMID:28392392 NCBI chr19:17,231,883...17,245,919
Ensembl chr19:17,231,883...17,245,919 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 decreases expression ISO Methylene Chloride results in decreased expression of NR3C1 mRNA CTD PMID:28392392 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512 		JBrowse link
G NRDC nardilysin convertase decreases expression ISO Methylene Chloride results in decreased expression of NRDC mRNA CTD PMID:28392392 NCBI chr 1:51,789,210...51,878,727
Ensembl chr 1:51,789,191...51,878,805 		JBrowse link
G ONECUT2 one cut homeobox 2 decreases expression ISO Methylene Chloride results in decreased expression of ONECUT2 mRNA CTD PMID:28392392 NCBI chr18:57,435,374...57,491,298
Ensembl chr18:57,435,374...57,491,298 		JBrowse link
G PELI1 pellino E3 ubiquitin protein ligase 1 increases expression EXP Methylene Chloride results in increased expression of PELI1 mRNA CTD PMID:20359517 NCBI chr 2:64,092,652...64,144,420
Ensembl chr 2:64,092,652...64,144,420 		JBrowse link
G PER3 period circadian regulator 3 increases expression ISO Methylene Chloride results in increased expression of PER3 mRNA CTD PMID:28392392 NCBI chr 1:7,784,291...7,845,177
Ensembl chr 1:7,784,291...7,845,177 		JBrowse link
G PF4 platelet factor 4 decreases expression ISO Methylene Chloride results in decreased expression of PF4 mRNA CTD PMID:20955722 NCBI chr 4:73,980,811...73,982,124
Ensembl chr 4:73,980,811...73,982,027 		JBrowse link
G PIAS1 protein inhibitor of activated STAT 1 decreases expression ISO Methylene Chloride results in decreased expression of PIAS1 mRNA CTD PMID:28392392 NCBI chr15:68,054,315...68,193,847
Ensembl chr15:68,054,309...68,198,603 		JBrowse link
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression EXP Methylene Chloride results in increased expression of PMAIP1 mRNA CTD PMID:20359517 NCBI chr18:59,899,996...59,904,305
Ensembl chr18:59,899,996...59,904,305 		JBrowse link
G PMVK phosphomevalonate kinase affects expression ISO Methylene Chloride affects the expression of PMVK mRNA CTD PMID:28392392 NCBI chr 1:154,924,740...154,942,658
Ensembl chr 1:154,924,740...154,936,719 		JBrowse link
G PPARD peroxisome proliferator activated receptor delta decreases expression ISO Methylene Chloride results in decreased expression of PPARD mRNA CTD PMID:28392392 NCBI chr 6:35,342,558...35,428,178
Ensembl chr 6:35,342,558...35,428,191 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha decreases expression ISO Methylene Chloride results in decreased expression of PPARGC1A mRNA CTD PMID:28392392 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089 		JBrowse link
G PRNP prion protein (Kanno blood group) increases expression EXP Methylene Chloride results in increased expression of PRNP mRNA CTD PMID:20359517 NCBI chr20:4,686,456...4,701,588
Ensembl chr20:4,686,350...4,701,590 		JBrowse link
G PTGER2 prostaglandin E receptor 2 increases expression EXP Methylene Chloride results in increased expression of PTGER2 mRNA CTD PMID:20359517 NCBI chr14:52,314,312...52,328,598
Ensembl chr14:52,314,305...52,328,598 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[Particulate Matter co-treated with Methylene Chloride] results in increased expression of PTGS2 mRNA]; [Particulate Matter co-treated with Methylene Chloride] results in increased expression of PTGS2 mRNA; carazolol inhibits the reaction [[Particulate Matter co-treated with Methylene Chloride] results in increased expression of PTGS2 mRNA] CTD PMID:30503853 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RAB8B RAB8B, member RAS oncogene family increases expression EXP Methylene Chloride results in increased expression of RAB8B mRNA CTD PMID:20359517 NCBI chr15:63,189,606...63,267,776
Ensembl chr15:63,189,560...63,267,776 		JBrowse link
G RELB RELB proto-oncogene, NF-kB subunit increases expression EXP Methylene Chloride results in increased expression of RELB mRNA CTD PMID:20359517 NCBI chr19:45,001,464...45,038,192
Ensembl chr19:45,001,461...45,038,192 		JBrowse link
G RFX4 regulatory factor X4 decreases expression ISO Methylene Chloride results in decreased expression of RFX4 mRNA CTD PMID:28392392 NCBI chr12:106,583,004...106,762,803
Ensembl chr12:106,583,004...106,762,803 		JBrowse link
G RNF149 ring finger protein 149 increases expression EXP Methylene Chloride results in increased expression of RNF149 mRNA CTD PMID:20359517 NCBI chr 2:101,271,219...101,308,701
Ensembl chr 2:101,271,219...101,308,701 		JBrowse link
G RORA RAR related orphan receptor A decreases expression ISO Methylene Chloride results in decreased expression of RORA mRNA CTD PMID:28392392 NCBI chr15:60,488,284...61,229,302
Ensembl chr15:60,488,284...61,229,302 		JBrowse link
G RREB1 ras responsive element binding protein 1 decreases expression ISO Methylene Chloride results in decreased expression of RREB1 mRNA CTD PMID:28392392 NCBI chr 6:7,107,743...7,251,980
Ensembl chr 6:7,107,597...7,251,980 		JBrowse link
G SALL1 spalt like transcription factor 1 decreases expression ISO Methylene Chloride results in decreased expression of SALL1 mRNA CTD PMID:28392392 NCBI chr16:51,135,982...51,152,334
Ensembl chr16:51,135,982...51,152,334 		JBrowse link
G SDHB succinate dehydrogenase complex iron sulfur subunit B affects expression
multiple interactions		 ISO Methylene Chloride affects the expression of SDHB protein
[propylene dichloride co-treated with Methylene Chloride] affects the expression of SDHB protein		 CTD PMID:30240022 NCBI chr 1:17,018,722...17,054,032
Ensembl chr 1:17,018,664...17,054,032 		JBrowse link
G SDHC succinate dehydrogenase complex subunit C multiple interactions
increases expression		 ISO [propylene dichloride co-treated with Methylene Chloride] affects the expression of SDHC protein
Methylene Chloride results in increased expression of SDHC protein		 CTD PMID:30240022 NCBI chr 1:161,314,381...161,363,206
Ensembl chr 1:161,314,381...161,363,206 		JBrowse link
G SDHD succinate dehydrogenase complex subunit D affects expression
multiple interactions		 ISO Methylene Chloride affects the expression of SDHD protein
[propylene dichloride co-treated with Methylene Chloride] affects the expression of SDHD protein		 CTD PMID:30240022 NCBI chr11:112,086,873...112,095,794
Ensembl chr11:112,086,824...112,120,016 		JBrowse link
G SELL selectin L increases expression ISO Methylene Chloride results in increased expression of SELL mRNA CTD PMID:20955722 NCBI chr 1:169,690,667...169,711,620
Ensembl chr 1:169,690,665...169,711,702 		JBrowse link
G SERPINB2 serpin family B member 2 multiple interactions EXP [Particulate Matter co-treated with Methylene Chloride] results in increased expression of SERPINB2 mRNA CTD PMID:30503853 NCBI chr18:63,887,705...63,903,888
Ensembl chr18:63,871,692...63,903,888 		JBrowse link
G SESN2 sestrin 2 increases expression EXP Methylene Chloride results in increased expression of SESN2 mRNA CTD PMID:20359517 NCBI chr 1:28,259,518...28,282,491
Ensembl chr 1:28,259,518...28,282,491 		JBrowse link
G SLC38A2 solute carrier family 38 member 2 increases expression EXP Methylene Chloride results in increased expression of SLC38A2 mRNA CTD PMID:20359517 NCBI chr12:46,358,188...46,372,773
Ensembl chr12:46,358,188...46,372,773 		JBrowse link
G SLC7A11 solute carrier family 7 member 11 increases expression EXP Methylene Chloride results in increased expression of SLC7A11 mRNA CTD PMID:20359517 NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349 		JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions ISO [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in decreased expression of SOD1 mRNA CTD PMID:29335169 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in decreased expression of SOD2 mRNA CTD PMID:29335169 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G SP3 Sp3 transcription factor increases expression ISO Methylene Chloride results in increased expression of SP3 mRNA CTD PMID:28392392 NCBI chr 2:173,900,775...173,965,702
Ensembl chr 2:173,880,850...173,965,373 		JBrowse link
G STAT5A signal transducer and activator of transcription 5A decreases expression ISO Methylene Chloride results in decreased expression of STAT5A mRNA CTD PMID:28392392 NCBI chr17:42,287,439...42,311,943
Ensembl chr17:42,287,547...42,311,943 		JBrowse link
G STAT5B signal transducer and activator of transcription 5B decreases expression
increases activity		 ISO Methylene Chloride results in decreased expression of STAT5B mRNA
Methylene Chloride results in increased activity of STAT5B protein		 CTD PMID:28392392 PMID:30114225 NCBI chr17:42,199,177...42,288,370
Ensembl chr17:42,199,176...42,288,633 		JBrowse link
G STX11 syntaxin 11 increases expression EXP Methylene Chloride results in increased expression of STX11 mRNA CTD PMID:20359517 NCBI chr 6:144,139,963...144,191,939
Ensembl chr 6:144,150,487...144,191,939 		JBrowse link
G TEF TEF transcription factor, PAR bZIP family member increases expression ISO Methylene Chloride results in increased expression of TEF mRNA CTD PMID:28392392 NCBI chr22:41,367,455...41,399,326
Ensembl chr22:41,367,333...41,399,326 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO [Methylene Chloride co-treated with Biliverdine] inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TNF protein] CTD PMID:15486963 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFAIP3 TNF alpha induced protein 3 increases expression EXP Methylene Chloride results in increased expression of TNFAIP3 mRNA CTD PMID:20359517 NCBI chr 6:137,866,349...137,883,312
Ensembl chr 6:137,867,214...137,883,314 		JBrowse link
G TRIP12 thyroid hormone receptor interactor 12 decreases expression ISO Methylene Chloride results in decreased expression of TRIP12 mRNA CTD PMID:20955722 NCBI chr 2:229,763,837...229,923,186
Ensembl chr 2:229,763,837...229,923,239 		JBrowse link
G TRPS1 transcriptional repressor GATA binding 1 increases expression ISO Methylene Chloride results in increased expression of TRPS1 mRNA CTD PMID:28392392 NCBI chr 8:115,408,496...115,668,975
Ensembl chr 8:115,408,496...115,809,673 		JBrowse link
G UQCRC2 ubiquinol-cytochrome c reductase core protein 2 multiple interactions ISO [propylene dichloride co-treated with Methylene Chloride] affects the expression of UQCRC2 protein CTD PMID:30240022 NCBI chr16:21,953,361...21,983,660
Ensembl chr16:21,953,288...21,983,660 		JBrowse link
G USP18 ubiquitin specific peptidase 18 increases expression EXP Methylene Chloride results in increased expression of USP18 mRNA CTD PMID:20359517 NCBI chr22:18,150,170...18,177,397
Ensembl chr22:18,150,118...18,177,397 		JBrowse link
G WEE1 WEE1 G2 checkpoint kinase increases expression ISO Methylene Chloride results in increased expression of WEE1 mRNA CTD PMID:28392392 NCBI chr11:9,573,670...9,589,985
Ensembl chr11:9,573,670...9,593,457 		JBrowse link
G WWP1 WW domain containing E3 ubiquitin protein ligase 1 decreases expression ISO Methylene Chloride results in decreased expression of WWP1 mRNA CTD PMID:20955722 NCBI chr 8:86,342,547...86,468,503
Ensembl chr 8:86,342,547...86,478,420 		JBrowse link
G XBP1 X-box binding protein 1 increases expression EXP Methylene Chloride results in increased expression of XBP1 mRNA CTD PMID:20359517 NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597 		JBrowse link
G ZBTB22 zinc finger and BTB domain containing 22 decreases expression ISO Methylene Chloride results in decreased expression of ZBTB22 mRNA CTD PMID:28392392 NCBI chr 6:33,314,418...33,317,942
Ensembl chr 6:33,314,406...33,317,942 		JBrowse link
G ZBTB41 zinc finger and BTB domain containing 41 decreases expression ISO Methylene Chloride results in decreased expression of ZBTB41 mRNA CTD PMID:28392392 NCBI chr 1:197,153,682...197,201,293
Ensembl chr 1:197,153,682...197,201,293 		JBrowse link
G ZC3HAV1 zinc finger CCCH-type containing, antiviral 1 increases expression EXP Methylene Chloride results in increased expression of ZC3HAV1 mRNA CTD PMID:20359517 NCBI chr 7:139,043,515...139,109,720
Ensembl chr 7:139,043,515...139,132,122 		JBrowse link
G ZCCHC2 zinc finger CCHC-type containing 2 increases expression EXP Methylene Chloride results in increased expression of ZCCHC2 mRNA CTD PMID:20359517 NCBI chr18:62,523,025...62,586,729
Ensembl chr18:62,523,025...62,587,709 		JBrowse link
G ZFHX4 zinc finger homeobox 4 decreases expression ISO Methylene Chloride results in decreased expression of ZFHX4 mRNA CTD PMID:28392392 NCBI chr 8:76,681,247...76,867,281
Ensembl chr 8:76,681,239...76,867,281 		JBrowse link
G ZFP37 ZFP37 zinc finger protein increases expression ISO Methylene Chloride results in increased expression of ZFP37 mRNA CTD PMID:28392392 NCBI chr 9:113,038,377...113,056,724
Ensembl chr 9:113,038,377...113,056,759 		JBrowse link
G ZFP62 ZFP62 zinc finger protein increases expression ISO Methylene Chloride results in increased expression of ZFP62 mRNA CTD PMID:28392392 NCBI chr 5:180,826,870...180,861,276
Ensembl chr 5:180,847,611...180,861,285 		JBrowse link
G ZHX1 zinc fingers and homeoboxes 1 increases expression
affects expression		 ISO Methylene Chloride results in increased expression of ZHX1 mRNA
Methylene Chloride affects the expression of ZHX1 mRNA		 CTD PMID:28392392 NCBI chr 8:123,248,456...123,275,541
Ensembl chr 8:123,248,451...123,275,541 		JBrowse link
G ZMAT1 zinc finger matrin-type 1 increases expression ISO Methylene Chloride results in increased expression of ZMAT1 mRNA CTD PMID:28392392 NCBI chr  X:101,882,290...101,932,027
Ensembl chr  X:101,882,288...101,932,031 		JBrowse link
G ZNF250 zinc finger protein 250 decreases expression ISO Methylene Chloride results in decreased expression of ZFP647 mRNA CTD PMID:28392392 NCBI chr 8:144,876,955...144,902,177
Ensembl chr 8:144,876,497...144,902,168 		JBrowse link
G ZNF260 zinc finger protein 260 increases expression
affects expression		 ISO Methylene Chloride results in increased expression of ZFP260 mRNA
Methylene Chloride affects the expression of ZFP260 mRNA		 CTD PMID:28392392 NCBI chr19:36,510,687...36,528,271
Ensembl chr19:36,510,687...36,528,271 		JBrowse link
G ZNF354B zinc finger protein 354B increases expression ISO Methylene Chloride results in increased expression of ZFP354B mRNA CTD PMID:28392392 NCBI chr 5:178,859,953...178,885,020
Ensembl chr 5:178,859,953...178,888,122 		JBrowse link
G ZNF429 zinc finger protein 429 increases expression ISO Methylene Chloride results in increased expression of ZFP58 mRNA CTD PMID:28392392 NCBI chr19:21,505,602...21,540,668
Ensembl chr19:21,496,682...21,556,270 		JBrowse link
G ZNF445 zinc finger protein 445 increases expression ISO Methylene Chloride results in increased expression of ZFP445 mRNA CTD PMID:28392392 NCBI chr 3:44,431,705...44,477,670
Ensembl chr 3:44,431,705...44,477,670 		JBrowse link
G ZNF451 zinc finger protein 451 decreases expression ISO Methylene Chloride results in decreased expression of ZFP451 mRNA CTD PMID:28392392 NCBI chr 6:57,090,188...57,170,305
Ensembl chr 6:57,086,844...57,170,305 		JBrowse link
G ZNF519 zinc finger protein 519 increases expression ISO Methylene Chloride results in increased expression of ZFP386 mRNA CTD PMID:28392392 NCBI chr18:14,071,121...14,132,435
Ensembl chr18:14,057,457...14,132,490 		JBrowse link
G ZNF562 zinc finger protein 562 decreases expression ISO Methylene Chloride results in decreased expression of ZFP266 mRNA CTD PMID:28392392 NCBI chr19:9,641,807...9,675,100
Ensembl chr19:9,641,807...9,675,100 		JBrowse link
G ZNF569 zinc finger protein 569 increases expression ISO Methylene Chloride results in increased expression of ZFP74 mRNA CTD PMID:28392392 NCBI chr19:37,411,157...37,469,265
Ensembl chr19:37,411,155...37,469,275 		JBrowse link
G ZNF788P zinc finger family member 788, pseudogene increases expression ISO Methylene Chloride results in increased expression of ZFP119A mRNA CTD PMID:28392392 NCBI chr19:12,092,297...12,114,753
Ensembl chr19:12,092,468...12,113,048 		JBrowse link
G ZSCAN12 zinc finger and SCAN domain containing 12 decreases expression ISO Methylene Chloride results in decreased expression of ZSCAN12 mRNA CTD PMID:28392392 NCBI chr 6:28,378,821...28,399,747
Ensembl chr 6:28,378,955...28,399,747 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    role 25957
      application 25179
        refrigerant 20348
          dichloromethane 197
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    main group molecular entity 25841
                      s-block molecular entity 25162
                        hydrogen molecular entity 24761
                          hydrides 22973
                            organic hydride 21936
                              organic fundamental parent 21936
                                hydrocarbon 21359
                                  halohydrocarbon 15928
                                    haloalkane 12795
                                      chloroalkane 9286
                                        chloromethanes 7397
                                          dichloromethane 197
paths to the root