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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dichloromethane
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Accession:CHEBI:15767 term browser browse the term
Definition:A member of the class of chloromethanes that is methane in which two of the hydrogens have been replaced by chlorine. A dense, non-flammible colourless liquid at room temperature (b.p. 40degreeC, d = 1.33) which is immiscible with water, it is widely used as a solvent, a paint stripper, and for the removal of caffeine from coffee and tea.
Synonyms:related_synonym: DCM;   Dichlormethan;   Formula=CH2Cl2;   InChI=1S/CH2Cl2/c2-1-3/h1H2;   InChIKey=YMWUJEATGCHHMB-UHFFFAOYSA-N;   Methylenchlorid;   Methylene chloride;   Methylene dichloride;   SMILES=[H]C([H])(Cl)Cl;   chlorure de methylene;   methane dichloride;   methylene bichloride
 alt_id: CHEBI:14139;   CHEBI:23701;   CHEBI:4504
 xref: Beilstein:1730800;   CAS:75-09-2;   Gmelin:1302;   HMDB:HMDB0031548;   KEGG:C02271;   KEGG:D02330
 xref_mesh: MESH:D008752
 xref: MetaCyc:CPD-681;   PMID:11884241;   PMID:19091298;   PMID:8465711;   Patent:US2792435;   Patent:US2979541;   Patent:US3126419;   Reaxys:1730800;   UM-BBD_compID:c0233;   Wikipedia:Dichloromethane


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dichloromethane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions ISO [Particulate Matter co-treated with Methylene Chloride] results in decreased expression of ADRB1 mRNA CTD PMID:30503853 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which affects the expression of AKT1 mRNA CTD PMID:29335169 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ar androgen receptor decreases expression ISO Methylene Chloride results in decreased expression of AR mRNA CTD PMID:28392392 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atf5 activating transcription factor 5 decreases expression ISO Methylene Chloride results in decreased expression of ATF5 mRNA CTD PMID:28392392 NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707 		JBrowse link
G Bach2 BTB domain and CNC homolog 2 decreases expression ISO Methylene Chloride results in decreased expression of BACH2 mRNA CTD PMID:28392392 NCBI chr 5:46,632,338...46,982,676
Ensembl chr 5:46,638,317...46,977,877 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which affects the expression of BCL2 mRNA CTD PMID:29335169 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression ISO Methylene Chloride results in increased expression of BCL2A1 mRNA CTD PMID:20359517 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998 		JBrowse link
G Bcl6 BCL6, transcription repressor increases expression ISO Methylene Chloride results in increased expression of BCL6 mRNA CTD PMID:20359517 PMID:28392392 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 increases expression ISO Methylene Chloride results in increased expression of BHLHE40 mRNA CTD PMID:28392392 NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO Methylene Chloride results in increased expression of BIRC3 mRNA CTD PMID:20359517 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 decreases expression ISO Methylene Chloride results in decreased expression of BMAL1 mRNA CTD PMID:28392392 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231 		JBrowse link
G Bnc1 basonuclin zinc finger protein 1 decreases expression ISO Methylene Chloride results in decreased expression of BNC1 mRNA CTD PMID:28392392 NCBI chr 1:135,917,676...135,943,333
Ensembl chr 1:135,917,687...135,943,333 		JBrowse link
G Btg1 BTG anti-proliferation factor 1 increases expression ISO Methylene Chloride results in increased expression of BTG1 mRNA CTD PMID:20359517 NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in increased expression of CASP1 mRNA CTD PMID:29335169 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Methylene Chloride co-treated with Biliverdine] inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of CASP3 protein]; Methylene Chloride inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of CASP3 protein] CTD PMID:15486963 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions ISO [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in decreased expression of CAT mRNA; [Lipopolysaccharides co-treated with Methylene Chloride] results in increased activity of CAT protein CTD PMID:15563889 PMID:29335169 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cblb Cbl proto-oncogene B increases expression EXP Methylene Chloride results in increased expression of CBLB mRNA CTD PMID:20955722 NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression EXP Methylene Chloride results in decreased expression of CCL5 mRNA CTD PMID:20955722 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Cd37 CD37 molecule decreases expression EXP Methylene Chloride results in decreased expression of CD37 mRNA CTD PMID:20955722 NCBI chr 1:95,719,171...95,724,662
Ensembl chr 1:95,719,190...95,724,648 		JBrowse link
G Cd38 CD38 molecule increases expression EXP Methylene Chloride results in increased expression of CD38 mRNA CTD PMID:20955722 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986 		JBrowse link
G Cd4 Cd4 molecule increases expression EXP Methylene Chloride results in increased expression of CD4 mRNA CTD PMID:20955722 NCBI chr 4:157,668,878...157,695,366 JBrowse link
G Cd8a CD8 subunit alpha increases expression EXP Methylene Chloride results in increased expression of CD8A mRNA CTD PMID:20955722 NCBI chr 4:103,365,804...103,370,041
Ensembl chr 4:103,365,804...103,370,040 		JBrowse link
G Cdh1 cadherin 1 affects expression ISO Methylene Chloride affects the expression of CDH1 mRNA CTD PMID:34280354 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO Methylene Chloride results in increased expression of CEBPB mRNA CTD PMID:28392392 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Ciita class II, major histocompatibility complex, transactivator increases expression EXP Methylene Chloride results in increased expression of CIITA mRNA CTD PMID:20955722 NCBI chr10:5,139,947...5,187,493
Ensembl chr10:5,140,178...5,187,440 		JBrowse link
G Clock clock circadian regulator decreases expression ISO Methylene Chloride results in decreased expression of CLOCK mRNA CTD PMID:28392392 NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400 		JBrowse link
G Creb3l1 cAMP responsive element binding protein 3-like 1 decreases expression ISO Methylene Chloride results in decreased expression of CREB3L1 mRNA CTD PMID:28392392 NCBI chr 3:77,952,589...77,993,513
Ensembl chr 3:77,952,540...77,993,456 		JBrowse link
G Creb3l2 cAMP responsive element binding protein 3-like 2 decreases expression ISO Methylene Chloride results in decreased expression of CREB3L2 mRNA CTD PMID:28392392 NCBI chr 4:65,907,570...66,112,078
Ensembl chr 4:65,907,655...66,023,763 		JBrowse link
G Crem cAMP responsive element modulator decreases expression ISO Methylene Chloride results in decreased expression of CREM mRNA CTD PMID:28392392 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989 		JBrowse link
G Cry1 cryptochrome circadian regulator 1 decreases expression ISO Methylene Chloride results in decreased expression of CRY1 mRNA CTD PMID:28392392 NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091 		JBrowse link
G Cry2 cryptochrome circadian regulator 2 increases expression ISO Methylene Chloride results in increased expression of CRY2 mRNA CTD PMID:28392392 NCBI chr 3:78,374,995...78,405,001
Ensembl chr 3:78,374,995...78,404,965 		JBrowse link
G Csde1 cold shock domain containing E1 increases expression ISO Methylene Chloride results in increased expression of CSDE1 mRNA CTD PMID:28392392 NCBI chr 2:190,546,015...190,582,787
Ensembl chr 2:190,554,980...190,582,784 		JBrowse link
G Cth cystathionine gamma-lyase increases expression ISO Methylene Chloride results in increased expression of CTH mRNA CTD PMID:20359517 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234 		JBrowse link
G Ctnnb1 catenin beta 1 increases mutagenesis ISO Methylene Chloride results in increased mutagenesis of CTNNB1 gene CTD PMID:10467420 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cux1 cut-like homeobox 1 decreases expression ISO Methylene Chloride results in decreased expression of CUX1 mRNA CTD PMID:28392392 NCBI chr12:20,107,062...20,425,868
Ensembl chr12:20,107,311...20,425,866 		JBrowse link
G Cux2 cut-like homeobox 2 decreases expression ISO Methylene Chloride results in decreased expression of CUX2 mRNA CTD PMID:28392392 NCBI chr12:34,507,723...34,707,581
Ensembl chr12:34,520,959...34,705,806 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 increases expression EXP Methylene Chloride results in increased expression of CXCR2 mRNA CTD PMID:20955722 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO Methylene Chloride results in increased expression of CXCR4 mRNA CTD PMID:20359517 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in increased expression of CYP1A1 mRNA CTD PMID:29335169 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects expression ISO Methylene Chloride affects the expression of CYP1A2 mRNA CTD PMID:28392392 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression ISO Methylene Chloride results in decreased expression of CYP1B1 mRNA CTD PMID:20359517 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 affects expression ISO Methylene Chloride affects the expression of CYP2C29 mRNA CTD PMID:28392392 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases metabolic processing
increases oxidation		 EXP
ISO		 3-xylene promotes the reaction [CYP2E1 protein results in increased metabolism of Methylene Chloride]; Benzene promotes the reaction [CYP2E1 protein results in increased metabolism of Methylene Chloride]; Toluene promotes the reaction [CYP2E1 protein results in increased metabolism of Methylene Chloride]
CYP2E1 protein results in increased oxidation of Methylene Chloride
[[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in increased expression of CYP2E1 mRNA		 CTD PMID:1664256 PMID:8889796 PMID:29335169 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp51 cytochrome P450, family 51 affects expression ISO Methylene Chloride affects the expression of CYP51 mRNA CTD PMID:28392392 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410 		JBrowse link
G Dapk1 death associated protein kinase 1 increases methylation ISO Methylene Chloride results in increased methylation of DAPK1 promoter CTD PMID:15172992 NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991 		JBrowse link
G Dbp D-box binding PAR bZIP transcription factor increases expression ISO Methylene Chloride results in increased expression of DBP mRNA CTD PMID:28392392 NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745 		JBrowse link
G Dennd5a DENN domain containing 5A increases expression ISO Methylene Chloride results in increased expression of DENND5A mRNA CTD PMID:20359517 NCBI chr 1:163,928,183...163,994,207
Ensembl chr 1:163,928,183...163,994,316 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase affects expression ISO Methylene Chloride affects the expression of DHCR24 mRNA CTD PMID:28392392 NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137 		JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO Methylene Chloride results in increased expression of DNAJB9 mRNA CTD PMID:20359517 NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063 		JBrowse link
G Ebp EBP, cholestenol delta-isomerase affects expression ISO Methylene Chloride affects the expression of EBP mRNA CTD PMID:28392392 NCBI chr  X:14,299,427...14,305,826
Ensembl chr  X:14,299,448...14,305,826 		JBrowse link
G Egr1 early growth response 1 affects expression ISO Methylene Chloride affects the expression of EGR1 mRNA CTD PMID:28392392 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Egr3 early growth response 3 increases expression ISO Methylene Chloride results in increased expression of EGR3 mRNA CTD PMID:20359517 NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627 		JBrowse link
G Elf1 E74 like ETS transcription factor 1 decreases expression ISO Methylene Chloride results in decreased expression of ELF1 mRNA CTD PMID:28392392 NCBI chr15:54,890,644...54,986,721
Ensembl chr15:54,865,616...54,986,699 		JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 increases expression ISO Methylene Chloride results in increased expression of ELOVL6 mRNA CTD PMID:20359517 NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO Methylene Chloride results in decreased expression of ESR1 mRNA CTD PMID:28392392 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Evi2a ecotropic viral integration site 2A increases expression ISO Methylene Chloride results in increased expression of EVI2A mRNA CTD PMID:20359517 NCBI chr10:64,485,760...64,489,660
Ensembl chr10:64,485,200...64,489,843 		JBrowse link
G Fcgr1a Fc gamma receptor 1A increases expression EXP Methylene Chloride results in increased expression of FCGR1 mRNA CTD PMID:20955722 NCBI chr 2:183,851,075...183,860,077
Ensembl chr 2:183,851,077...183,859,994 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 affects expression ISO Methylene Chloride affects the expression of FDFT1 mRNA CTD PMID:28392392 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287 		JBrowse link
G Fdps farnesyl diphosphate synthase affects expression ISO Methylene Chloride affects the expression of FDPS mRNA CTD PMID:28392392 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776 		JBrowse link
G Filip1l filamin A interacting protein 1-like increases expression ISO Methylene Chloride results in increased expression of FILIP1L mRNA CTD PMID:20359517 NCBI chr11:42,937,353...43,177,085
Ensembl chr11:42,940,467...43,177,415 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Methylene Chloride results in decreased expression of FOS mRNA CTD PMID:28392392 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Foxa1 forkhead box A1 decreases expression ISO Methylene Chloride results in decreased expression of FOXA1 mRNA CTD PMID:28392392 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188 		JBrowse link
G Foxo3 forkhead box O3 increases expression ISO Methylene Chloride results in increased expression of FOXO3 mRNA CTD PMID:28392392 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Methylene Chloride results in increased expression of GADD45A mRNA CTD PMID:20359517 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in decreased expression of GCLC mRNA CTD PMID:29335169 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gp1bb glycoprotein Ib platelet subunit beta decreases expression EXP Methylene Chloride results in decreased expression of GP1BB mRNA CTD PMID:20955722 NCBI chr11:82,378,216...82,379,393
Ensembl chr11:82,378,199...82,379,392 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which affects the expression of GPX1 mRNA CTD PMID:29335169 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO [Lipopolysaccharides co-treated with Methylene Chloride] results in increased activity of GSR protein CTD PMID:15563889 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects metabolic processing
affects response to substance
increases metabolic processing
multiple interactions		 ISO
EXP		 GSTT1 gene polymorphism affects the metabolism of Methylene Chloride; GSTT1 protein affects the metabolism of Methylene Chloride
GSTT1 protein alternative form affects the susceptibility to Methylene Chloride
GSTT1 protein results in increased metabolism of Methylene Chloride
[GSTT1 protein affects the metabolism of Methylene Chloride] which results in increased abundance of Formaldehyde; GSTT1 protein affects the metabolism of and results in increased activity of Methylene Chloride
GSTT1 protein results in increased metabolism of and results in increased activity of Methylene Chloride		 CTD PMID:7979958 PMID:8670055 PMID:8761485 PMID:9854036 PMID:10413528 More... NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Herc1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 decreases expression EXP Methylene Chloride results in decreased expression of HERC1 mRNA CTD PMID:20955722 NCBI chr 8:66,857,169...67,070,318
Ensembl chr 8:66,856,935...67,070,312 		JBrowse link
G Hes6 hes family bHLH transcription factor 6 increases expression ISO Methylene Chloride results in increased expression of HES6 mRNA CTD PMID:28392392 NCBI chr 9:92,001,849...92,003,562
Ensembl chr 9:92,001,841...92,003,559 		JBrowse link
G Hivep2 HIVEP zinc finger 2 increases expression ISO Methylene Chloride results in increased expression of HIVEP2 mRNA CTD PMID:20359517 NCBI chr 1:8,358,205...8,555,993
Ensembl chr 1:8,359,289...8,555,993 		JBrowse link
G Hlf HLF transcription factor, PAR bZIP family member increases expression ISO Methylene Chloride results in increased expression of HLF mRNA CTD PMID:28392392 NCBI chr10:75,154,244...75,211,884
Ensembl chr10:75,154,507...75,211,935 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO Methylene Chloride results in increased expression of HMOX1 mRNA
[Particulate Matter co-treated with Methylene Chloride] results in increased expression of HMOX1 mRNA
[[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which affects the expression of HMOX1 mRNA		 CTD PMID:20359517 PMID:29335169 PMID:30503853 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnrnpll heterogeneous nuclear ribonucleoprotein L-like increases expression ISO Methylene Chloride results in increased expression of HNRNPLL mRNA CTD PMID:20359517 NCBI chr 6:14,969,953...15,000,574
Ensembl chr 6:14,970,057...14,999,745 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 affects expression ISO Methylene Chloride affects the expression of HSD17B7 mRNA CTD PMID:28392392 NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017 		JBrowse link
G Id3 inhibitor of DNA binding 3 decreases expression ISO Methylene Chloride results in decreased expression of ID3 mRNA CTD PMID:28392392 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 affects expression ISO Methylene Chloride affects the expression of IDI1 mRNA CTD PMID:28392392 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357 		JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 increases expression ISO Methylene Chloride results in increased expression of IFIT2 mRNA CTD PMID:20359517 NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635 		JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 increases expression ISO Methylene Chloride results in increased expression of IFIT3 mRNA CTD PMID:20359517 NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Methylene Chloride co-treated with Biliverdine] inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IFNG protein] CTD PMID:15486963 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ifngr2 interferon gamma receptor 2 increases expression ISO Methylene Chloride results in increased expression of IFNGR2 mRNA CTD PMID:20359517 NCBI chr11:30,779,733...30,798,005
Ensembl chr11:30,779,733...30,798,005 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Methylene Chloride co-treated with Biliverdine] inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL10 protein] CTD PMID:15486963 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Particulate Matter co-treated with Methylene Chloride] results in increased expression of IL1A mRNA CTD PMID:30503853 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in increased expression of IL1RN mRNA CTD PMID:29335169 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il2rg interleukin 2 receptor subunit gamma increases expression EXP Methylene Chloride results in increased expression of IL2RG mRNA CTD PMID:20955722 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Methylene Chloride co-treated with Biliverdine] inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL6 protein] CTD PMID:15486963 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il7r interleukin 7 receptor decreases expression EXP Methylene Chloride results in decreased expression of IL7R mRNA CTD PMID:20955722 NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757 		JBrowse link
G Il9 interleukin 9 increases expression EXP Methylene Chloride results in increased expression of IL9 mRNA CTD PMID:20955722 NCBI chr17:8,111,772...8,114,895
Ensembl chr17:8,111,772...8,114,895 		JBrowse link
G Irf5 interferon regulatory factor 5 decreases expression ISO Methylene Chloride results in decreased expression of IRF5 mRNA CTD PMID:28392392 NCBI chr 4:58,127,577...58,140,665
Ensembl chr 4:58,127,640...58,139,267 		JBrowse link
G Irf6 interferon regulatory factor 6 decreases expression ISO Methylene Chloride results in decreased expression of IRF6 mRNA CTD PMID:28392392 NCBI chr13:104,672,179...104,691,386
Ensembl chr13:104,672,179...104,691,386 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Methylene Chloride results in increased expression of JUN mRNA CTD PMID:28392392 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Methylene Chloride results in increased expression of JUNB mRNA CTD PMID:28392392 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Klf13 KLF transcription factor 13 decreases expression ISO Methylene Chloride results in decreased expression of KLF13 mRNA CTD PMID:28392392 NCBI chr 1:117,505,857...117,536,626
Ensembl chr 1:117,503,602...117,551,227 		JBrowse link
G Lss lanosterol synthase affects expression ISO Methylene Chloride affects the expression of LSS mRNA CTD PMID:28392392 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762 		JBrowse link
G Mafb MAF bZIP transcription factor B increases expression ISO Methylene Chloride results in increased expression of MAFB mRNA CTD PMID:28392392 NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 increases expression ISO Methylene Chloride results in increased expression of MAP3K8 mRNA CTD PMID:20359517 NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 multiple interactions ISO [propylene dichloride co-treated with Methylene Chloride] affects the activity of and affects the expression of MGST1 protein; Methylene Chloride affects the activity of and affects the expression of MGST1 protein CTD PMID:30240022 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO [Particulate Matter co-treated with Methylene Chloride] results in increased expression of MMP1 mRNA; carazolol inhibits the reaction [[Particulate Matter co-treated with Methylene Chloride] results in increased expression of MMP1 mRNA] CTD PMID:30503853 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO Methylene Chloride results in increased expression of MMP9 mRNA CTD PMID:34280354 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I multiple interactions
decreases expression		 ISO [propylene dichloride co-treated with Methylene Chloride] affects the expression of COX1 protein
Methylene Chloride results in decreased expression of COX1 protein		 CTD PMID:30240022 NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867 		JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which affects the expression of MT2 mRNA CTD PMID:29335169 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Mvd mevalonate diphosphate decarboxylase affects expression ISO Methylene Chloride affects the expression of MVD mRNA CTD PMID:28392392 NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971 		JBrowse link
G Mvk mevalonate kinase affects expression ISO Methylene Chloride affects the expression of MVK mRNA CTD PMID:28392392 NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882 		JBrowse link
G Mxd1 max dimerization protein 1 increases expression ISO Methylene Chloride results in increased expression of MXD1 mRNA CTD PMID:20359517 NCBI chr 4:119,097,353...119,118,080
Ensembl chr 4:119,097,353...119,117,751 		JBrowse link
G Mysm1 myb-like, SWIRM and MPN domains 1 decreases expression ISO Methylene Chloride results in decreased expression of MYSM1 mRNA CTD PMID:28392392 NCBI chr 5:109,761,345...109,826,652
Ensembl chr 5:109,776,286...109,819,967 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase decreases expression ISO Methylene Chloride results in decreased expression of NAMPT mRNA CTD PMID:28392392 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 decreases expression EXP Methylene Chloride results in decreased expression of NCAM1 mRNA CTD PMID:20955722 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 increases expression ISO Methylene Chloride results in increased expression of NCF2 mRNA CTD PMID:20359517 NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 decreases expression ISO Methylene Chloride results in decreased expression of NCOR1 mRNA CTD PMID:28392392 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032 		JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 increases expression ISO Methylene Chloride results in increased expression of NDUFB8 protein CTD PMID:30240022 NCBI chr 1:243,408,656...243,413,715
Ensembl chr 1:243,408,619...243,413,817 		JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 multiple interactions
affects expression		 ISO [propylene dichloride co-treated with Methylene Chloride] results in decreased expression of NDUFS3 protein
Methylene Chloride affects the expression of NDUFS3 protein		 CTD PMID:30240022 NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824 		JBrowse link
G Nectin3 nectin cell adhesion molecule 3 decreases expression EXP Methylene Chloride results in decreased expression of NECTIN3 mRNA CTD PMID:20955722 NCBI chr11:54,362,712...54,469,351
Ensembl chr11:54,364,487...54,462,519 		JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 increases expression ISO Methylene Chloride results in increased expression of NEDD9 mRNA CTD PMID:20359517 NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019 		JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 increases expression ISO Methylene Chloride results in increased expression of NFAT5 mRNA CTD PMID:20359517 NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675 		JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 decreases expression EXP Methylene Chloride results in decreased expression of NFATC3 mRNA CTD PMID:20955722 NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity
multiple interactions
increases expression		 ISO Methylene Chloride results in increased activity of NFE2L2 protein
[[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which affects the expression of NFE2L2 mRNA
Methylene Chloride results in increased expression of NFE2L2 mRNA		 CTD PMID:29335169 PMID:30114225 PMID:30203046 PMID:34280354 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfib nuclear factor I/B increases expression ISO Methylene Chloride results in increased expression of NFIB mRNA CTD PMID:20359517 NCBI chr 5:96,759,208...96,974,001
Ensembl chr 5:96,764,653...96,975,479 		JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated decreases expression ISO Methylene Chloride results in decreased expression of NFIL3 mRNA CTD PMID:28392392 NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO Methylene Chloride results in increased expression of NFKBIA mRNA CTD PMID:20359517 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in increased expression of NOS2 mRNA; Methylene Chloride inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Methylene Chloride inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:15563889 PMID:29335169 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Npas2 neuronal PAS domain protein 2 decreases expression ISO Methylene Chloride results in decreased expression of NPAS2 mRNA CTD PMID:28392392 NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which affects the expression of NQO1 mRNA CTD PMID:29335169 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 increases expression ISO Methylene Chloride results in increased expression of NR1D1 mRNA CTD PMID:28392392 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705 		JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression ISO Methylene Chloride results in increased expression of NR1D2 mRNA CTD PMID:28392392 NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553 		JBrowse link
G Nr2f6 nuclear receptor subfamily 2, group F, member 6 increases expression ISO Methylene Chloride results in increased expression of NR2F6 mRNA CTD PMID:28392392 NCBI chr16:18,046,012...18,053,914
Ensembl chr16:18,046,013...18,053,459 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression ISO Methylene Chloride results in decreased expression of NR3C1 mRNA CTD PMID:28392392 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nrdc nardilysin convertase decreases expression ISO Methylene Chloride results in decreased expression of NRDC mRNA CTD PMID:28392392 NCBI chr 5:123,755,807...123,818,910
Ensembl chr 5:123,755,806...123,818,595 		JBrowse link
G Onecut2 one cut homeobox 2 decreases expression ISO Methylene Chloride results in decreased expression of ONECUT2 mRNA CTD PMID:28392392 NCBI chr18:57,831,647...57,890,884
Ensembl chr18:57,832,111...57,879,629 		JBrowse link
G Peli1 pellino E3 ubiquitin protein ligase 1 increases expression ISO Methylene Chloride results in increased expression of PELI1 mRNA CTD PMID:20359517 NCBI chr14:95,254,274...95,309,168
Ensembl chr14:95,254,589...95,308,285 		JBrowse link
G Per3 period circadian regulator 3 increases expression ISO Methylene Chloride results in increased expression of PER3 mRNA CTD PMID:28392392 NCBI chr 5:161,460,228...161,495,404
Ensembl chr 5:161,459,533...161,495,607 		JBrowse link
G Pf4 platelet factor 4 decreases expression EXP Methylene Chloride results in decreased expression of PF4 mRNA CTD PMID:20955722 NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365 		JBrowse link
G Pias1 protein inhibitor of activated STAT, 1 decreases expression ISO Methylene Chloride results in decreased expression of PIAS1 mRNA CTD PMID:28392392 NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:63,338,150...63,438,905 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Methylene Chloride results in increased expression of PMAIP1 mRNA CTD PMID:20359517 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Pmvk phosphomevalonate kinase affects expression ISO Methylene Chloride affects the expression of PMVK mRNA CTD PMID:28392392 NCBI chr 2:174,876,586...174,886,365
Ensembl chr 2:174,876,657...174,886,364 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta decreases expression ISO Methylene Chloride results in decreased expression of PPARD mRNA CTD PMID:28392392 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression ISO Methylene Chloride results in decreased expression of PPARGC1A mRNA CTD PMID:28392392 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prnp prion protein increases expression ISO Methylene Chloride results in increased expression of PRNP mRNA CTD PMID:20359517 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937 		JBrowse link
G Ptger2 prostaglandin E receptor 2 increases expression ISO Methylene Chloride results in increased expression of PTGER2 mRNA CTD PMID:20359517 NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [[Particulate Matter co-treated with Methylene Chloride] results in increased expression of PTGS2 mRNA]; [Particulate Matter co-treated with Methylene Chloride] results in increased expression of PTGS2 mRNA; carazolol inhibits the reaction [[Particulate Matter co-treated with Methylene Chloride] results in increased expression of PTGS2 mRNA] CTD PMID:30503853 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rab8b RAB8B, member RAS oncogene family increases expression ISO Methylene Chloride results in increased expression of RAB8B mRNA CTD PMID:20359517 NCBI chr 8:67,458,921...67,536,466
Ensembl chr 8:67,458,923...67,536,384 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit increases expression ISO Methylene Chloride results in increased expression of RELB mRNA CTD PMID:20359517 NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507 		JBrowse link
G Rfx4 regulatory factor X4 decreases expression ISO Methylene Chloride results in decreased expression of RFX4 mRNA CTD PMID:28392392 NCBI chr 7:18,853,065...19,015,378
Ensembl chr 7:18,853,322...19,014,967 		JBrowse link
G Rnf149 ring finger protein 149 increases expression ISO Methylene Chloride results in increased expression of RNF149 mRNA CTD PMID:20359517 NCBI chr 9:41,826,825...41,854,381
Ensembl chr 9:41,830,233...41,854,279 		JBrowse link
G Rora RAR-related orphan receptor A decreases expression ISO Methylene Chloride results in decreased expression of RORA mRNA CTD PMID:28392392 NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931 		JBrowse link
G Rreb1 ras responsive element binding protein 1 decreases expression ISO Methylene Chloride results in decreased expression of RREB1 mRNA CTD PMID:28392392 NCBI chr17:26,876,687...27,002,554
Ensembl chr17:26,876,697...27,002,615 		JBrowse link
G RT1-Ba RT1 class II, locus Ba increases expression EXP Methylene Chloride results in increased expression of RT1-BA mRNA CTD PMID:20955722 NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 increases expression EXP Methylene Chloride results in increased expression of RT1-DB1 mRNA CTD PMID:20955722 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
G RT1-DMb RT1 class II, locus DMb increases expression EXP Methylene Chloride results in increased expression of HLA-DMB mRNA CTD PMID:20955722 NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340 		JBrowse link
G Sall1 spalt-like transcription factor 1 decreases expression ISO Methylene Chloride results in decreased expression of SALL1 mRNA CTD PMID:28392392 NCBI chr19:18,005,782...18,022,705
Ensembl chr19:18,007,503...18,022,705 		JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B multiple interactions
affects expression		 ISO [propylene dichloride co-treated with Methylene Chloride] affects the expression of SDHB protein
Methylene Chloride affects the expression of SDHB protein		 CTD PMID:30240022 NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293 		JBrowse link
G Sdhc succinate dehydrogenase complex subunit C increases expression
multiple interactions		 ISO Methylene Chloride results in increased expression of SDHC protein
[propylene dichloride co-treated with Methylene Chloride] affects the expression of SDHC protein		 CTD PMID:30240022 NCBI chr13:83,544,652...83,565,560
Ensembl chr13:83,544,652...83,566,253 		JBrowse link
G Sdhd succinate dehydrogenase complex subunit D affects expression
multiple interactions		 ISO Methylene Chloride affects the expression of SDHD protein
[propylene dichloride co-treated with Methylene Chloride] affects the expression of SDHD protein		 CTD PMID:30240022 NCBI chr 8:50,944,702...50,954,298
Ensembl chr 8:50,944,704...50,954,238 		JBrowse link
G Sell selectin L increases expression EXP Methylene Chloride results in increased expression of SELL mRNA CTD PMID:20955722 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Serpinb2 serpin family B member 2 multiple interactions ISO [Particulate Matter co-treated with Methylene Chloride] results in increased expression of SERPINB2 mRNA CTD PMID:30503853 NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408 		JBrowse link
G Sesn2 sestrin 2 increases expression ISO Methylene Chloride results in increased expression of SESN2 mRNA CTD PMID:20359517 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260 		JBrowse link
G Slc38a2 solute carrier family 38, member 2 increases expression ISO Methylene Chloride results in increased expression of SLC38A2 mRNA CTD PMID:20359517 NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Methylene Chloride results in increased expression of SLC7A11 mRNA CTD PMID:20359517 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in decreased expression of SOD1 mRNA CTD PMID:29335169 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [[Particulate Matter co-treated with Methylene Chloride] results in increased abundance of Polycyclic Aromatic Hydrocarbons] which results in decreased expression of SOD2 mRNA CTD PMID:29335169 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sp3 Sp3 transcription factor increases expression ISO Methylene Chloride results in increased expression of SP3 mRNA CTD PMID:28392392 NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A decreases expression ISO Methylene Chloride results in decreased expression of STAT5A mRNA CTD PMID:28392392 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B decreases expression
increases activity		 ISO Methylene Chloride results in decreased expression of STAT5B mRNA
Methylene Chloride results in increased activity of STAT5B protein		 CTD PMID:28392392 PMID:30114225 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668 		JBrowse link
G Stx11 syntaxin 11 increases expression ISO Methylene Chloride results in increased expression of STX11 mRNA CTD PMID:20359517 NCBI chr 1:7,293,427...7,320,060
Ensembl chr 1:7,289,976...7,320,164 		JBrowse link
G Tef TEF transcription factor, PAR bZIP family member increases expression ISO Methylene Chloride results in increased expression of TEF mRNA CTD PMID:28392392 NCBI chr 7:113,317,191...113,341,783
Ensembl chr 7:113,317,283...113,341,783 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Methylene Chloride co-treated with Biliverdine] inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TNF protein] CTD PMID:15486963 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO Methylene Chloride results in increased expression of TNFAIP3 mRNA CTD PMID:20359517 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Trip12 thyroid hormone receptor interactor 12 decreases expression EXP Methylene Chloride results in decreased expression of TRIP12 mRNA CTD PMID:20955722 NCBI chr 9:85,916,691...86,043,312
Ensembl chr 9:85,916,691...86,051,403 		JBrowse link
G Trps1 transcriptional repressor GATA binding 1 increases expression ISO Methylene Chloride results in increased expression of TRPS1 mRNA CTD PMID:28392392 NCBI chr 7:81,916,668...82,142,733
Ensembl chr 7:81,921,601...82,141,905 		JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 multiple interactions ISO [propylene dichloride co-treated with Methylene Chloride] affects the expression of UQCRC2 protein CTD PMID:30240022 NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453 		JBrowse link
G Usp18 ubiquitin specific peptidase 18 increases expression ISO Methylene Chloride results in increased expression of USP18 mRNA CTD PMID:20359517 NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144 		JBrowse link
G Wee1 WEE1 G2 checkpoint kinase increases expression ISO Methylene Chloride results in increased expression of WEE1 mRNA CTD PMID:28392392 NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688 		JBrowse link
G Wwp1 WW domain containing E3 ubiquitin protein ligase 1 decreases expression EXP Methylene Chloride results in decreased expression of WWP1 mRNA CTD PMID:20955722 NCBI chr 5:33,092,379...33,185,887
Ensembl chr 5:33,098,494...33,186,046 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO Methylene Chloride results in increased expression of XBP1 mRNA CTD PMID:20359517 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Zbtb22 zinc finger and BTB domain containing 22 decreases expression ISO Methylene Chloride results in decreased expression of ZBTB22 mRNA CTD PMID:28392392 NCBI chr20:4,966,331...4,969,853
Ensembl chr20:4,966,271...4,969,498 		JBrowse link
G Zbtb41 zinc finger and BTB domain containing 41 decreases expression ISO Methylene Chloride results in decreased expression of ZBTB41 mRNA CTD PMID:28392392 NCBI chr13:51,042,948...51,065,768
Ensembl chr13:51,042,948...51,065,768 		JBrowse link
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 increases expression ISO Methylene Chloride results in increased expression of ZC3HAV1 mRNA CTD PMID:20359517 NCBI chr 4:67,012,129...67,062,428
Ensembl chr 4:67,012,185...67,062,428 		JBrowse link
G Zcchc2 zinc finger CCHC-type containing 2 increases expression ISO Methylene Chloride results in increased expression of ZCCHC2 mRNA CTD PMID:20359517 NCBI chr13:22,118,677...22,193,626
Ensembl chr13:22,119,568...22,166,373 		JBrowse link
G Zfhx4 zinc finger homeobox 4 decreases expression ISO Methylene Chloride results in decreased expression of ZFHX4 mRNA CTD PMID:28392392 NCBI chr 2:96,224,763...96,408,245
Ensembl chr 2:96,224,767...96,408,228 		JBrowse link
G Zfp260 zinc finger protein 260 affects expression
increases expression		 ISO Methylene Chloride affects the expression of ZFP260 mRNA
Methylene Chloride results in increased expression of ZFP260 mRNA		 CTD PMID:28392392 NCBI chr 1:85,336,567...85,349,896
Ensembl chr 1:85,336,618...85,350,067 		JBrowse link
G Zfp266 zinc finger protein 266 decreases expression ISO Methylene Chloride results in decreased expression of ZFP266 mRNA CTD PMID:28392392 NCBI chr 8:19,030,766...19,061,381
Ensembl chr 8:19,030,768...19,060,937 		JBrowse link
G Zfp37 zinc finger protein 37 increases expression ISO Methylene Chloride results in increased expression of ZFP37 mRNA CTD PMID:28392392 NCBI chr 5:75,598,732...75,638,896
Ensembl chr 5:75,598,732...75,638,942 		JBrowse link
G Zfp386 zinc finger protein 386 (Kruppel-like) increases expression ISO Methylene Chloride results in increased expression of ZFP386 mRNA CTD PMID:28392392 NCBI chr 6:136,966,547...136,984,013
Ensembl chr 6:136,966,586...136,983,441 		JBrowse link
G Zfp445 zinc finger protein 445 increases expression ISO Methylene Chloride results in increased expression of ZFP445 mRNA CTD PMID:28392392 NCBI chr 8:122,453,175...122,473,355
Ensembl chr 8:122,454,328...122,473,286 		JBrowse link
G Zfp451 zinc finger protein 451 decreases expression ISO Methylene Chloride results in decreased expression of ZFP451 mRNA CTD PMID:28392392 NCBI chr 9:35,985,441...36,040,991
Ensembl chr 9:35,985,443...36,040,652 		JBrowse link
G Zfp472 zinc finger protein 472 increases expression ISO Methylene Chloride results in increased expression of ZFP119A mRNA CTD PMID:28392392 NCBI chr 7:12,074,623...12,082,890
Ensembl chr 7:12,074,603...12,082,892 		JBrowse link
G Zfp51 zinc finger protein 51 increases expression ISO Methylene Chloride results in increased expression of ZFP51 mRNA CTD PMID:28392392 NCBI chr 1:61,203,159...61,235,545
Ensembl chr 1:61,191,368...61,235,540 		JBrowse link
G Zfp58 zinc finger protein 58 increases expression ISO Methylene Chloride results in increased expression of ZFP58 mRNA CTD PMID:28392392 NCBI chr 1:35,020,477...35,053,203
Ensembl chr 1:35,002,321...35,033,216 		JBrowse link
G Zfp62 zinc finger protein 62 increases expression ISO Methylene Chloride results in increased expression of ZFP62 mRNA CTD PMID:28392392 NCBI chr10:33,522,618...33,539,446
Ensembl chr10:33,500,323...33,542,013 		JBrowse link
G Zfp647 zinc finger protein 647 decreases expression ISO Methylene Chloride results in decreased expression of ZFP647 mRNA CTD PMID:28392392 NCBI chr 7:108,632,248...108,649,264
Ensembl chr 7:108,632,250...108,637,433 		JBrowse link
G Zfp708 zinc finger protein 708 increases expression ISO Methylene Chloride results in increased expression of ZFP708 mRNA CTD PMID:28392392 NCBI chr 2:84,473,436...84,525,070
Ensembl chr 2:84,473,454...84,523,500 		JBrowse link
G Zfp74 zinc finger protein 74 increases expression ISO Methylene Chloride results in increased expression of ZFP74 mRNA CTD PMID:28392392 NCBI chr 1:85,158,159...85,183,407
Ensembl chr 1:85,158,980...85,183,522 		JBrowse link
G Zfp758 zinc finger protein 758 affects expression
increases expression		 ISO Methylene Chloride affects the expression of ZFP758 mRNA
Methylene Chloride results in increased expression of ZFP758 mRNA		 CTD PMID:28392392 NCBI chr 1:61,941,284...61,989,354
Ensembl chr 1:61,942,116...61,989,490 		JBrowse link
G Zfp948 zinc finger protein 948 increases expression ISO Methylene Chloride results in increased expression of ZFP948 mRNA CTD PMID:28392392 NCBI chr 1:61,366,068...61,396,300
Ensembl chr 1:61,368,076...61,395,282 		JBrowse link
G Zhx1 zinc fingers and homeoboxes 1 affects expression
increases expression		 ISO Methylene Chloride affects the expression of ZHX1 mRNA
Methylene Chloride results in increased expression of ZHX1 mRNA		 CTD PMID:28392392 NCBI chr 7:89,582,363...89,611,337
Ensembl chr 7:89,582,243...89,611,264 		JBrowse link
G Zmat1 zinc finger, matrin-type 1 increases expression ISO Methylene Chloride results in increased expression of ZMAT1 mRNA CTD PMID:28392392 NCBI chr  X:98,168,388...98,199,415
Ensembl chr  X:98,168,456...98,199,733 		JBrowse link
G Znf354b zinc finger protein 354B increases expression ISO Methylene Chloride results in increased expression of ZFP354B mRNA CTD PMID:28392392 NCBI chr10:35,233,783...35,251,110
Ensembl chr10:35,185,028...35,245,505 		JBrowse link
G Zscan12 zinc finger and SCAN domain containing 12 decreases expression ISO Methylene Chloride results in decreased expression of ZSCAN12 mRNA CTD PMID:28392392 NCBI chr17:43,247,250...43,253,206
Ensembl chr17:43,247,095...43,253,264 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      application 19741
        refrigerant 18307
          dichloromethane 198
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    main group molecular entity 19876
                      s-block molecular entity 19705
                        hydrogen molecular entity 19686
                          hydrides 19179
                            organic hydride 18717
                              organic fundamental parent 18717
                                hydrocarbon 18457
                                  halohydrocarbon 15874
                                    haloalkane 12902
                                      chloroalkane 9355
                                        chloromethanes 7519
                                          dichloromethane 198
paths to the root