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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tyramine
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Accession:CHEBI:15760 term browser browse the term
Definition:A primary amino compound obtained by formal decarboxylation of the amino acid tyrosine.
Synonyms:related_synonym: 2-(p-Hydroxyphenyl)ethylamine;   4-(2-aminoethyl)phenol;   4-Hydroxy-beta-phenylethylamine;   4-Hydroxyphenylethylamine;   4-hydroxyphenethylamine;   Formula=C8H11NO;   InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2;   InChIKey=DZGWFCGJZKJUFP-UHFFFAOYSA-N;   SMILES=NCCc1ccc(O)cc1;   Tyramin;   beta-(4-Hydroxyphenyl)ethylamine;   p-(2-Aminoethyl)phenol;   p-hydroxyphenethylamine;   p-hydroxyphenylethylamine;   p-tyramine
 alt_id: CHEBI:15276;   CHEBI:27174;   CHEBI:9799
 xref: CAS:51-67-2;   Drug_Central:2784;   Gmelin:82946;   HMDB:HMDB0000306;   KEGG:C00483;   KNApSAcK:C00001435;   LINCS:LSM-19016
 xref_mesh: MESH:D014439
 xref: MetaCyc:TYRAMINE;   PDBeChem:AEF;   PMID:11361052;   PMID:11919655;   PMID:12183041;   PMID:12707242;   PMID:12811595;   PMID:15000446;   PMID:15848803;   PMID:15932098;   PMID:18422653;   PMID:18970430;   PMID:19137318;   PMID:19189084;   PMID:21570963;   PMID:21628600;   PMID:21651557;   PMID:21679153;   PMID:21850574;   PMID:21909937;   PMID:22735334;   PMID:3137238;   PMID:319927;   PMID:6501508;   PMID:9282832;   PMID:9731223;   Reaxys:1099914;   Wikipedia:Tyramine
 cyclic_relationship: is_conjugate_base_of CHEBI:327995


show annotations for term's descendants           Sort by:
tyramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions EXP CAT protein results in decreased susceptibility to [Tyramine co-treated with Aluminum] CTD PMID:15526171 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
multiple interactions 		ISO CYP2D6 protein results in increased metabolism of Tyramine
[CYP2D6 protein results in increased metabolism of Tyramine] which results in increased abundance of Dopamine 		CTD PMID:26763401 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Gast gastrin decreases cleavage EXP Tyramine results in decreased cleavage of GAST protein CTD PMID:10332097 NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496 		JBrowse link
G Maoa monoamine oxidase A increases metabolic processing ISO MAOA protein results in increased metabolism of Tyramine CTD PMID:10647887 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Tyramine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Tyramine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions ISO Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
G Taar1 trace-amine-associated receptor 1 multiple interactions
increases activity 		ISO [Tyramine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP; Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]; SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]; SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein] CTD PMID:17234900 PMID:19725810 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084 		JBrowse link
compound 48/80 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO p-Methoxy-N-methylphenethylamine results in increased secretion of CCL2 protein CTD PMID:34826398 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Gusb glucuronidase, beta increases secretion EXP p-Methoxy-N-methylphenethylamine results in increased secretion of GUSB protein CTD PMID:9545557 NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905 		JBrowse link
G Hexa hexosaminidase subunit alpha increases secretion
multiple interactions 		ISO p-Methoxy-N-methylphenethylamine results in increased secretion of HEXA protein
Apigenin inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased secretion of HEXA protein] 		CTD PMID:36350155 NCBI chr 8:59,936,526...59,961,654
Ensembl chr 8:59,936,660...59,962,013 		JBrowse link
G Hexb hexosaminidase subunit beta increases secretion ISO p-Methoxy-N-methylphenethylamine results in increased secretion of HEXB protein CTD PMID:34774977 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A increases activity EXP p-Methoxy-N-methylphenethylamine results in increased activity of HTR1A protein CTD PMID:16415902 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase affects response to substance ISO KIT protein affects the susceptibility to p-Methoxy-N-methylphenethylamine CTD PMID:32871113 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Kng1 kininogen 1 decreases activity ISO p-Methoxy-N-methylphenethylamine results in decreased activity of KNG1 protein CTD PMID:1371395 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions
increases activity 		EXP atractylon inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; damnacanthal inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; pyeongwee-san extract inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein] CTD PMID:27553716 NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation 		ISO epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK1 protein] CTD PMID:29402411 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation 		ISO epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK3 protein] CTD PMID:29402411 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mrgprx2 MAS related GPR family member X2 affects response to substance ISO MRGPRX2 protein affects the susceptibility to p-Methoxy-N-methylphenethylamine CTD PMID:32871113 NCBI chr 1:98,116,192...98,135,534 JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases activity ISO p-Methoxy-N-methylphenethylamine results in decreased activity of NR3C1 protein CTD PMID:7887964 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Tnf tumor necrosis factor increases secretion ISO p-Methoxy-N-methylphenethylamine results in increased secretion of TNF protein CTD PMID:34826398 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tpsb2 tryptase beta 2 increases secretion ISO p-Methoxy-N-methylphenethylamine results in increased secretion of TPSB2 protein CTD PMID:34826398 NCBI chr10:14,381,779...14,383,571
Ensembl chr10:14,382,013...14,383,569 		JBrowse link
N,O-dimethyltyramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO p-Methoxy-N-methylphenethylamine results in increased secretion of CCL2 protein CTD PMID:34826398 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Gusb glucuronidase, beta increases secretion EXP p-Methoxy-N-methylphenethylamine results in increased secretion of GUSB protein CTD PMID:9545557 NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905 		JBrowse link
G Hexa hexosaminidase subunit alpha multiple interactions
increases secretion 		ISO Apigenin inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased secretion of HEXA protein] CTD PMID:36350155 NCBI chr 8:59,936,526...59,961,654
Ensembl chr 8:59,936,660...59,962,013 		JBrowse link
G Hexb hexosaminidase subunit beta increases secretion ISO p-Methoxy-N-methylphenethylamine results in increased secretion of HEXB protein CTD PMID:34774977 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A increases activity EXP p-Methoxy-N-methylphenethylamine results in increased activity of HTR1A protein CTD PMID:16415902 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase affects response to substance ISO KIT protein affects the susceptibility to p-Methoxy-N-methylphenethylamine CTD PMID:32871113 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Kng1 kininogen 1 decreases activity ISO p-Methoxy-N-methylphenethylamine results in decreased activity of KNG1 protein CTD PMID:1371395 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions
increases activity 		EXP atractylon inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; damnacanthal inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein]; pyeongwee-san extract inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased activity of LCK protein] CTD PMID:27553716 NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions 		ISO p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK1 protein
epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK1 protein] 		CTD PMID:29402411 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation 		ISO epigallocatechin gallate inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased phosphorylation of MAPK3 protein] CTD PMID:29402411 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mrgprx2 MAS related GPR family member X2 affects response to substance ISO MRGPRX2 protein affects the susceptibility to p-Methoxy-N-methylphenethylamine CTD PMID:32871113 NCBI chr 1:98,116,192...98,135,534 JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases activity ISO p-Methoxy-N-methylphenethylamine results in decreased activity of NR3C1 protein CTD PMID:7887964 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Tnf tumor necrosis factor increases secretion ISO p-Methoxy-N-methylphenethylamine results in increased secretion of TNF protein CTD PMID:34826398 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tpsb2 tryptase beta 2 increases secretion ISO p-Methoxy-N-methylphenethylamine results in increased secretion of TPSB2 protein CTD PMID:34826398 NCBI chr10:14,381,779...14,383,571
Ensembl chr10:14,382,013...14,383,569 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20845
    role 20805
      biological role 20803
        molecular messenger 19423
          monoamine molecular messenger 643
            tyramine 24
              3-nitrotyramine 0
              N,O-dimethyltyramine + 14
              N-acetyltyramine 0
              N-butanoyltyramine 0
              N-hexanoyltyramine 0
              N-trans-cinnamoyltyramine 0
              gamma-glutamyltyramine 0
              norbelladine + 0
              tyramine phosphate 0
              tyramine sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20845
    subatomic particle 20843
      composite particle 20843
        hadron 20843
          baryon 20843
            nucleon 20843
              atomic nucleus 20843
                atom 20843
                  main group element atom 20766
                    main group molecular entity 20766
                      s-block molecular entity 20561
                        hydrogen molecular entity 20545
                          hydrides 19679
                            inorganic hydride 18572
                              pnictogen hydride 18558
                                nitrogen hydride 18469
                                  azane 18229
                                    ammonia 18228
                                      organic amino compound 18228
                                        aralkylamino compound 1092
                                          monoamine 643
                                            monoamine molecular messenger 643
                                              tyramine 24
                                                3-nitrotyramine 0
                                                N,O-dimethyltyramine + 14
                                                N-acetyltyramine 0
                                                N-butanoyltyramine 0
                                                N-hexanoyltyramine 0
                                                N-trans-cinnamoyltyramine 0
                                                gamma-glutamyltyramine 0
                                                norbelladine + 0
                                                tyramine phosphate 0
                                                tyramine sulfate 0
paths to the root