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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:spermine
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Accession:CHEBI:15746 term browser browse the term
Definition:A polyazaalkane that is tetradecane in which the carbons at positions 1, 5, 10 and 14 are replaced by nitrogens. Spermine has broad actions on cellular metabolism.
Synonyms:related_synonym: 4,9-diaza-1,12-dodecanediamine;   4,9-diazadodecane-1,12-diamine;   Formula=C10H26N4;   InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2;   InChIKey=PFNFFQXMRSDOHW-UHFFFAOYSA-N;   N,N'-Bis(3-aminopropyl)-1,4-butanediamine;   N,N'-bis(3-aminopropyl)butane-1,4-diamine;   SMILES=NCCCNCCCCNCCCN
 alt_id: CHEBI:15098;   CHEBI:26734;   CHEBI:45583;   CHEBI:9219
 xref: Beilstein:1750791;   CAS:71-44-3;   DrugBank:DB00127;   Gmelin:454653;   HMDB:HMDB0001256;   KEGG:C00750;   KNApSAcK:C00001432
 xref_mesh: MESH:D013096
 xref: MetaCyc:SPERMINE;   PDBeChem:SPM;   PMID:10873205;   PMID:10930630;   PMID:11341774;   PMID:11543598;   PMID:11805860;   PMID:15145762;   PMID:15308338;   PMID:15500473;   PMID:15972654;   PMID:16146631;   PMID:16253230;   PMID:16664713;   PMID:19275753;   PMID:19593412;   PMID:19962967;   PMID:22735334;   PMID:23289636;   PMID:23418509;   PMID:23506248;   PMID:23820617;   PMID:23887925;   PMID:7521253;   PMID:7721849;   PMID:8524182;   PMID:8832899;   PMID:9151701;   Reaxys:1750791;   Wikipedia:Spermine
 cyclic_relationship: is_conjugate_base_of CHEBI:45725



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spermine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn2 actinin alpha 2 increases expression ISO Spermine results in increased expression of ACTN2 mRNA CTD PMID:18673383 NCBI chr17:58,143,334...58,210,622
Ensembl chr17:58,142,625...58,210,622
JBrowse link
G Actn3 actinin alpha 3 increases expression ISO Spermine results in increased expression of ACTN3 mRNA CTD PMID:18673383 NCBI chr 1:202,159,081...202,175,012
Ensembl chr 1:202,159,082...202,175,012
JBrowse link
G Adrb1 adrenoceptor beta 1 affects binding ISO Spermine binds to ADRB1 protein CTD PMID:20885010 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
G Adrb2 adrenoceptor beta 2 affects binding ISO Spermine binds to ADRB2 protein CTD PMID:20885010 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Ankrd2 ankyrin repeat domain 2 increases expression ISO Spermine results in increased expression of ANKRD2 mRNA CTD PMID:18673383 NCBI chr 1:240,847,111...240,856,563
Ensembl chr 1:240,847,072...240,856,566
JBrowse link
G Asic1 acid sensing ion channel subunit 1 decreases response to substance
multiple interactions
increases activity
ISO
EXP
ASIC1 gene mutant form results in decreased susceptibility to Spermine
Spider Venoms inhibits the reaction [Spermine results in increased activity of ASIC1 protein]
CTD PMID:21307247 NCBI chr 7:130,798,317...130,828,535
Ensembl chr 7:130,799,917...130,828,541
JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 increases expression ISO Spermine results in increased expression of ATP2A1 mRNA CTD PMID:18673383 NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
decreases expression
EXP
ISO
Spermine results in increased expression of BCL2 protein
Spermine results in decreased expression of BCL2 protein
CTD PMID:16151648 PMID:17606387 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bves blood vessel epicardial substance increases expression ISO Spermine results in increased expression of BVES mRNA CTD PMID:18673383 NCBI chr20:48,819,241...48,860,282
Ensembl chr20:48,822,308...48,857,472
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
ISO
EXP
Spermine inhibits the reaction [Dexamethasone results in increased activity of CASP3 protein]
Spermine results in decreased expression of CASP3 protein
CTD PMID:11399061 PMID:17606387 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 decreases activity ISO Spermine results in decreased activity of CASP7 protein CTD PMID:11281655 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Spermine inhibits the reaction [Dexamethasone results in increased activity of CASP8 protein] CTD PMID:11399061 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
decreases expression
ISO
EXP
Spermine inhibits the reaction [Dexamethasone results in increased activity of CASP9 protein]
Spermine results in decreased expression of CASP9 protein
CTD PMID:11399061 PMID:17606387 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Casr calcium-sensing receptor multiple interactions EXP
ISO
NPS R-467 promotes the reaction [Spermine binds to and results in increased activity of CASR protein]; Phenylephrine inhibits the reaction [Spermine binds to and results in increased activity of CASR protein]; Spermine binds to and results in increased activity of CASR protein; Thapsigargin inhibits the reaction [Spermine binds to and results in increased activity of CASR protein]
2-aminoethoxydiphenyl borate inhibits the reaction [Spermine binds to and results in increased activity of CASR protein]; [Spermine binds to and results in increased activity of CASR protein] which results in increased uptake of Calcium; Lanthanum inhibits the reaction [Spermine binds to and results in increased activity of CASR protein]; Spermine binds to and results in increased activity of CASR protein
CTD PMID:11071898 PMID:17041782 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811
JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit increases expression ISO Spermine results in increased expression of CHRNA1 mRNA CTD PMID:18673383 NCBI chr 3:58,454,763...58,469,832
Ensembl chr 3:58,454,744...58,469,840
JBrowse link
G Ckm creatine kinase, M-type increases expression ISO Spermine results in increased expression of CKM mRNA CTD PMID:18673383 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
JBrowse link
G Cobl cordon-bleu WH2 repeat protein increases expression ISO Spermine results in increased expression of COBL mRNA CTD PMID:18673383 NCBI chr14:86,828,137...87,060,682
Ensembl chr14:86,828,139...87,060,800
JBrowse link
G Col19a1 collagen type XIX alpha 1 chain increases expression ISO Spermine results in increased expression of COL19A1 mRNA CTD PMID:18673383 NCBI chr 9:26,673,916...27,022,139
Ensembl chr 9:26,675,391...27,022,106
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein affects localization ISO Spermine affects the localization of DIABLO protein CTD PMID:16151648 NCBI chr12:33,055,784...33,070,400
Ensembl chr12:33,055,263...33,070,387
JBrowse link
G Dmd dystrophin increases expression ISO Spermine results in increased expression of DMD mRNA CTD PMID:18673383 NCBI chr  X:47,272,324...49,504,219
Ensembl chr  X:47,272,331...49,504,207
JBrowse link
G Dmp1 dentin matrix acidic phosphoprotein 1 increases expression ISO Spermine results in increased expression of DMP1 mRNA CTD PMID:18673383 NCBI chr14:5,528,441...5,542,078
Ensembl chr14:5,528,431...5,539,323
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Spermine results in increased expression of FABP1 mRNA CTD PMID:18673383 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions EXP Spermine inhibits the reaction [Oxygen deficiency results in increased expression of FIS1 protein] CTD PMID:25911325 NCBI chr12:19,708,558...19,723,392
Ensembl chr12:19,708,558...19,723,377
JBrowse link
G Gja5 gap junction protein, alpha 5 increases expression ISO Spermine results in increased expression of GJA5 mRNA; Spermine results in increased expression of GJA5 protein CTD PMID:18673383 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions EXP Spermine inhibits the reaction [4-(3-(4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl)-2-hydroxy-propoxy)-benzamide binds to and results in decreased activity of GRIN2B protein]; Spermine inhibits the reaction [ifenprodil binds to and results in decreased activity of GRIN2B protein] CTD PMID:9729614 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Ibsp integrin-binding sialoprotein increases expression ISO Spermine results in increased expression of IBSP mRNA CTD PMID:18673383 NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions
ISO IDH2 protein mutant form results in increased abundance of Spermine
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Spermine]
CTD PMID:27469509 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
G Ky kyphoscoliosis peptidase increases expression ISO Spermine results in increased expression of KY mRNA CTD PMID:18673383 NCBI chr 8:103,086,630...103,126,305
Ensembl chr 8:103,086,630...103,126,024
JBrowse link
G Lmod2 leiomodin 2 increases expression ISO Spermine results in increased expression of LMOD2 mRNA CTD PMID:18673383 NCBI chr 4:53,067,428...53,075,124
Ensembl chr 4:53,067,428...53,075,120
JBrowse link
G Map4 microtubule-associated protein 4 increases expression ISO Spermine results in increased expression of MAP4 mRNA CTD PMID:18673383 NCBI chr 8:109,925,233...110,064,370
Ensembl chr 8:109,925,575...110,064,362
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [Spermine results in increased activity of MAPK8 protein]; Selenomethionine inhibits the reaction [Spermine results in increased activity of MAPK8 protein] CTD PMID:20121705 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mef2c myocyte enhancer factor 2C increases expression ISO Spermine results in increased expression of MEF2C mRNA CTD PMID:18673383 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [Spermine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]; [Spermine binds to TEMPO] inhibits the reaction [MPO protein results in increased degradation of Hydrogen Peroxide]; [Spermine binds to TEMPO] inhibits the reaction [MPO protein results in increased oxidation of Nitric Oxide]; Heparin inhibits the reaction [[Spermine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]] CTD PMID:34085520 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mybph myosin binding protein H increases expression ISO Spermine results in increased expression of MYBPH mRNA CTD PMID:18673383 NCBI chr13:45,653,156...45,660,893
Ensembl chr13:45,653,234...45,660,893
JBrowse link
G Myf5 myogenic factor 5 increases expression ISO Spermine results in increased expression of MYF5 mRNA CTD PMID:18673383 NCBI chr 7:42,802,946...42,806,177
Ensembl chr 7:42,802,946...42,806,177
JBrowse link
G Myf6 myogenic factor 6 increases expression ISO Spermine results in increased expression of MYF6 mRNA CTD PMID:18673383 NCBI chr 7:42,813,008...42,814,852
Ensembl chr 7:42,812,792...42,814,852
JBrowse link
G Myh1 myosin heavy chain 1 increases expression ISO Spermine results in increased expression of MYH1 mRNA CTD PMID:18673383 NCBI chr10:51,885,913...51,909,699
Ensembl chr10:51,885,913...51,946,295
JBrowse link
G Myh3 myosin heavy chain 3 increases expression ISO Spermine results in increased expression of MYH3 mRNA CTD PMID:18673383 NCBI chr10:51,770,177...51,793,994
Ensembl chr10:51,770,177...51,793,992
JBrowse link
G Myh8 myosin heavy chain 8 increases expression ISO Spermine results in increased expression of MYH8 mRNA CTD PMID:18673383 NCBI chr10:51,963,510...51,993,103
Ensembl chr10:51,963,510...51,993,232
JBrowse link
G Myl1 myosin, light chain 1 increases expression ISO Spermine results in increased expression of MYL1 mRNA CTD PMID:18673383 NCBI chr 9:68,437,514...68,458,256
Ensembl chr 9:68,437,517...68,458,261
JBrowse link
G Mylpf myosin light chain, phosphorylatable, fast skeletal muscle increases expression ISO Spermine results in increased expression of MYL11 mRNA CTD PMID:18673383 NCBI chr 1:181,829,703...181,832,546
Ensembl chr 1:181,829,743...181,832,545
JBrowse link
G Myod1 myogenic differentiation 1 increases expression ISO Spermine results in increased expression of MYOD1 mRNA; Spermine results in increased expression of MYOD1 protein CTD PMID:18673383 NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554
JBrowse link
G Myog myogenin increases expression ISO Spermine results in increased expression of MYOG mRNA CTD PMID:18673383 NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039
JBrowse link
G Myom2 myomesin 2 increases expression ISO Spermine results in increased expression of MYOM2 mRNA CTD PMID:18673383 NCBI chr16:74,520,148...74,592,658
Ensembl chr16:74,520,157...74,592,772
JBrowse link
G Neb nebulin increases expression ISO Spermine results in increased expression of NEB mRNA CTD PMID:18673383 NCBI chr 3:36,613,677...36,811,618
Ensembl chr 3:36,613,716...36,811,574
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization ISO Spermine affects the localization of NFE2L2 protein CTD PMID:12763045 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases activity
ISO Selenomethionine inhibits the reaction [Spermine results in increased activity of NOS2 protein] CTD PMID:20121705 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nppa natriuretic peptide A increases expression ISO Spermine results in increased expression of NPPA protein CTD PMID:18673383 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases activity
ISO pimagedine inhibits the reaction [Spermine results in increased activity of NQO1 protein] CTD PMID:12763045 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Odc1 ornithine decarboxylase 1 increases abundance
multiple interactions
ISO
EXP
ODC1 protein results in increased abundance of Spermine
[[Ornithine Decarboxylase Inhibitors results in decreased activity of ODC1 protein] which results in decreased chemical synthesis of Polyamines] which results in decreased abundance of Spermine; [ODC1 protein results in increased chemical synthesis of Polyamines] which results in increased abundance of Spermine; [Pentanoic Acids results in decreased activity of ODC1 protein] which results in decreased abundance of Spermine
CTD PMID:20805360 PMID:22555848 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Ryr1 ryanodine receptor 1 increases expression ISO Spermine results in increased expression of RYR1 mRNA CTD PMID:18673383 NCBI chr 1:84,292,578...84,423,799
Ensembl chr 1:84,292,578...84,423,812
JBrowse link
G Scn8a sodium voltage-gated channel alpha subunit 8 increases expression ISO Spermine results in increased expression of SCN8A mRNA CTD PMID:18673383 NCBI chr 7:131,982,152...132,156,075
Ensembl chr 7:131,982,480...132,151,292
JBrowse link
G Smox spermine oxidase multiple interactions
increases oxidation
ISO [SMOX protein results in increased oxidation of Spermine] which results in increased abundance of Spermidine CTD PMID:23707493 NCBI chr 3:118,731,814...118,767,242
Ensembl chr 3:118,731,900...118,765,710
JBrowse link
G Smyd1 SET and MYND domain containing 1 increases expression ISO Spermine results in increased expression of SMYD1 mRNA CTD PMID:18673383 NCBI chr 4:103,195,330...103,252,989
Ensembl chr 4:103,200,322...103,311,766
JBrowse link
G Tnnc2 troponin C2, fast skeletal type increases expression ISO Spermine results in increased expression of TNNC2 mRNA CTD PMID:18673383 NCBI chr 3:153,513,272...153,516,033
Ensembl chr 3:153,513,271...153,516,029
JBrowse link
G Tnni1 troponin I1, slow skeletal type increases expression ISO Spermine results in increased expression of TNNI1 mRNA CTD PMID:18673383 NCBI chr13:47,229,217...47,241,640
Ensembl chr13:47,229,216...47,241,644
JBrowse link
G Tnni2 troponin I2, fast skeletal type increases expression ISO Spermine results in increased expression of TNNI2 mRNA CTD PMID:18673383 NCBI chr 1:197,595,012...197,597,554
Ensembl chr 1:197,594,813...197,597,560
JBrowse link
G Tnnt1 troponin T1, slow skeletal type increases expression ISO Spermine results in increased expression of TNNT1 mRNA CTD PMID:18673383 NCBI chr 1:69,306,362...69,316,721
Ensembl chr 1:69,306,362...69,316,721
JBrowse link
G Tnnt3 troponin T3, fast skeletal type increases expression ISO Spermine results in increased expression of TNNT3 mRNA CTD PMID:18673383 NCBI chr 1:197,652,535...197,669,736
Ensembl chr 1:197,652,431...197,669,535
JBrowse link
G Tpm2 tropomyosin 2 increases expression ISO Spermine results in increased expression of TPM2 mRNA CTD PMID:18673383 NCBI chr 5:57,770,919...57,780,278
Ensembl chr 5:57,770,864...57,779,992
JBrowse link
G Trdn triadin increases expression ISO Spermine results in increased expression of TRDN mRNA CTD PMID:18673383 NCBI chr 1:23,955,651...24,410,494
Ensembl chr 1:23,955,651...24,410,595
JBrowse link
G Ttn titin increases expression ISO Spermine results in increased expression of TTN mRNA CTD PMID:18673383 NCBI chr 3:61,652,432...61,924,912
Ensembl chr 3:61,652,439...61,924,741
JBrowse link
G Unc5c unc-5 netrin receptor C increases expression ISO Spermine results in increased expression of UNC5C mRNA CTD PMID:18673383 NCBI chr 2:230,180,353...230,535,219
Ensembl chr 2:230,180,951...230,535,217
JBrowse link
G Vgll2 vestigial-like family member 2 increases expression ISO Spermine results in increased expression of VGLL2 mRNA CTD PMID:18673383 NCBI chr20:31,409,529...31,415,408
Ensembl chr20:31,409,552...31,415,408
JBrowse link
G Xirp1 xin actin-binding repeat containing 1 increases expression ISO Spermine results in increased expression of XIRP1 mRNA CTD PMID:18673383 NCBI chr 8:119,744,778...119,757,547
Ensembl chr 8:119,747,419...119,757,349
JBrowse link
N(1),N(12)-diethylspermine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sat1 spermidine/spermine N1-acetyl transferase 1 multiple interactions
increases expression
ISO [N(1), N(12)-diethylspermine co-treated with Fluorouracil] results in increased activity of SAT1 protein; [N(1), N(12)-diethylspermine co-treated with stallimycin] results in increased activity of SAT1 protein; stallimycin promotes the reaction [N(1), N(12)-diethylspermine results in increased expression of SAT1 protein] CTD PMID:21814787 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      chemical role 19544
        antioxidant 15014
          spermine 66
            N(4)-aminopropylspermine 0
            substituted spermine + 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    main group molecular entity 19956
                      s-block molecular entity 19752
                        hydrogen molecular entity 19745
                          hydrides 19114
                            inorganic hydride 17882
                              pnictogen hydride 17865
                                nitrogen hydride 17754
                                  azane 17503
                                    ammonia 17502
                                      organic amino compound 17502
                                        polyamine 8321
                                          tetramine 185
                                            spermine 66
                                              N(4)-aminopropylspermine 0
                                              substituted spermine + 1
paths to the root