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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:succinic acid
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Accession:CHEBI:15741 term browser browse the term
Definition:An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.
Synonyms:related_synonym: 1,2-ethanedicarboxylic acid;   Bernsteinsaeure;   Butandisaeure;   Butanedionic acid;   Dihydrofumaric acid;   E363;   Ethylenesuccinic acid;   Formula=C4H6O4;   HOOC-CH2-CH2-COOH;   InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8);   InChIKey=KDYFGRWQOYBRFD-UHFFFAOYSA-N;   SMILES=OC(=O)CCC(O)=O;   acide butanedioique;   acide succinique;   acidum succinicum;   amber acid;   asuccin;   butanedioic acid;   spirit of amber
 alt_id: CHEBI:22943;   CHEBI:26807;   CHEBI:45639;   CHEBI:9304
 xref: Beilstein:1754069;   CAS:110-15-6;   DrugBank:DB00139;   Drug_Central:2487;   ECMDB:ECMDB00254;   Gmelin:2785;   HMDB:HMDB0000254;   KEGG:C00042;   KNApSAcK:C00001205;   LIPID_MAPS_instance:LMFA01170043
 xref_mesh: MESH:D019802
 xref: MetaCyc:SUC;   PDBeChem:SIN;   PMID:17439666;   Reaxys:1754069;   Wikipedia:Succinic_acid;   YMDB:YMDB00338
 cyclic_relationship: is_conjugate_acid_of CHEBI:30779



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succinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in increased expression of BAX mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in increased expression of BAX protein CTD PMID:31401087 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of BCL2L1 mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of BCL2L1 protein CTD PMID:31401087 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid] CTD PMID:24709313 NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Dek DEK proto-oncogene multiple interactions ISO DEK protein affects the chemical synthesis of and affects the secretion of Succinic Acid CTD PMID:28558019 NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808
JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor increases abundance ISO ERCC6 gene mutant form results in increased abundance of Succinic Acid CTD PMID:25440059 NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP Succinic Acid inhibits the reaction [Rotenone affects the expression of HIF1A protein] CTD PMID:16034640 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of Succinic Acid CTD PMID:20567778 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of MYC mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of MYC protein CTD PMID:31401087 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of NFKB1 mRNA CTD PMID:31401087 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO [Glycerol co-treated with Succinic Acid co-treated with Glucose-6-Phosphate co-treated with Pantothenic Acid co-treated with Niacinamide] results in increased expression of NR4A1 mRNA CTD PMID:20505214 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of PTGS2 mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of PTGS2 protein CTD PMID:31401087 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of RELA mRNA CTD PMID:31401087 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slc13a3 solute carrier family 13 member 3 affects binding ISO
EXP
Succinic Acid binds to SLC13A3 protein CTD PMID:12397032 NCBI chr 3:154,141,878...154,204,604
Ensembl chr 3:154,141,872...154,204,606
JBrowse link
G Slc22a25 solute carrier family 22, member 25 multiple interactions EXP Succinic Acid inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate] CTD PMID:18441515 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects abundance ISO SLCO1A4 protein affects the abundance of Succinic Acid CTD PMID:21561886 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of STAT3 mRNA CTD PMID:31401087 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
artesunate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression
ISO Deferoxamine inhibits the reaction [Artesunate results in decreased expression of ACTA2 mRNA]
Artesunate results in decreased expression of ACTA2 mRNA; Artesunate results in decreased expression of ACTA2 protein
Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
CTD PMID:30551460 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO artesunate affects the localization of AIFM1 protein CTD PMID:24704559 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Ar androgen receptor multiple interactions ISO artesunate binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Atg12 autophagy related 12 increases expression ISO Artesunate results in increased expression of ATG12 mRNA CTD PMID:30551460 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
JBrowse link
G Atg3 autophagy related 3 increases expression ISO Artesunate results in increased expression of ATG3 mRNA CTD PMID:30551460 NCBI chr11:55,624,928...55,653,212
Ensembl chr11:55,624,917...55,653,224
JBrowse link
G Atg5 autophagy related 5 increases expression ISO Artesunate results in increased expression of ATG5 mRNA CTD PMID:30551460 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO
EXP
Artesunate results in increased expression of BAX protein
[1,2-Dimethylhydrazine co-treated with artesunate] results in increased expression of BAX protein
CTD PMID:24704559 PMID:29031619 PMID:33002460 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
Artesunate results in decreased expression of BCL2 protein
3-methyladenine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; acadesine promotes the reaction [Artesunate results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; Sirolimus promotes the reaction [Artesunate results in decreased expression of BCL2 protein]
[1,2-Dimethylhydrazine co-treated with artesunate] results in decreased expression of BCL2 protein
CTD PMID:24704559 PMID:29031619 PMID:33002460 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bst1 bone marrow stromal cell antigen 1 increases response to substance ISO BST1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr14:67,253,706...67,270,203
Ensembl chr14:67,252,998...67,270,180
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
multiple interactions
ISO artesunate results in increased activity of CASP3 protein
Artesunate results in increased cleavage of CASP3 protein
3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of CASP3 protein]
CTD PMID:19513562 PMID:24704559 PMID:33002460 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 affects expression ISO artesunate affects the expression of CASP9 protein CTD PMID:24704559 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase increases expression
decreases response to substance
ISO artesunate results in increased expression of CAT protein
CAT protein results in decreased susceptibility to artesunate
CTD PMID:19513562 PMID:20144594 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 decreases response to substance ISO CCT2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions
increases phosphorylation
ISO APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK1 protein] CTD PMID:31664825 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
increases phosphorylation
ISO APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK2 protein] CTD PMID:31664825 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Clip4 CAP-GLY domain containing linker protein family, member 4 increases response to substance ISO CLIP4 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 6:23,616,280...23,697,625
Ensembl chr 6:23,616,281...23,677,874
JBrowse link
G Coq8a coenzyme Q8A decreases response to substance ISO COQ8A mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr13:91,904,731...91,933,588
Ensembl chr13:91,904,739...91,931,431
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein] CTD PMID:29031619 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Dbh dopamine beta-hydroxylase increases response to substance ISO DBH mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
JBrowse link
G Des desmin multiple interactions
decreases expression
ISO Deferoxamine inhibits the reaction [Artesunate results in decreased expression of DES mRNA]
Artesunate results in decreased expression of DES mRNA; Artesunate results in decreased expression of DES protein
CTD PMID:30551460 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO artesunate binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO artesunate results in increased expression of FAS protein CTD PMID:19513562 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Flna filamin A increases response to substance ISO FLNA mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr  X:152,007,758...152,034,266
Ensembl chr  X:152,007,758...152,031,052
JBrowse link
G Fn1 fibronectin 1 multiple interactions
decreases expression
ISO Deferoxamine inhibits the reaction [Artesunate results in decreased expression of FN1 mRNA]
Artesunate results in decreased expression of FN1 mRNA; Artesunate results in decreased expression of FN1 protein
CTD PMID:30551460 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fth1 ferritin heavy chain 1 decreases expression
multiple interactions
ISO Artesunate results in decreased expression of FTH1 mRNA; Artesunate results in decreased expression of FTH1 protein
Chloroquine inhibits the reaction [Artesunate results in decreased expression of FTH1 mRNA]
CTD PMID:30551460 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Fzd7 frizzled class receptor 7 increases response to substance ISO FZD7 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit affects response to substance
decreases response to substance
ISO GCLC mRNA affects the susceptibility to artesunate
GCLC mRNA results in decreased susceptibility to artesunate
CTD PMID:15796179 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit decreases response to substance ISO GCLM mRNA results in decreased susceptibility to artesunate CTD PMID:15796179 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases activity
multiple interactions
ISO Artesunate results in decreased activity of GPX4 protein
Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of GPX4 protein]
CTD PMID:30551460 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Gstm4 glutathione S-transferase mu 4 affects response to substance ISO GSTM4 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression ISO artesunate results in decreased expression of GSTP1 protein CTD PMID:19513562 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gstt2 glutathione S-transferase, theta 2 affects response to substance ISO GSTT2 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288
JBrowse link
G Gstz1 glutathione S-transferase zeta 1 affects response to substance ISO GSTZ1 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284
JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases phosphorylation
ISO APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of H2AX protein] CTD PMID:31664825 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Artesunate inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL1B protein] CTD PMID:27474069 PMID:30031708 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Artesunate inhibits the reaction [Ethanol results in increased expression of IL6 protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL6 protein] CTD PMID:27474069 PMID:30031708 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgb1 integrin subunit beta 1 increases response to substance ISO ITGB1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases lipidation
ISO 3-methyladenine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; acadesine promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; dorsomorphin inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Sirolimus promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein] CTD PMID:33002460 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 affects response to substance ISO MGST3 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein] CTD PMID:29031619 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
EXP
ISO
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MMP9 protein]
Chloroquine inhibits the reaction [Artesunate results in decreased expression of MMP9 mRNA]
CTD PMID:29031619 PMID:30551460 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP artesunate inhibits the reaction [Ethanol results in increased activity of MPO protein] CTD PMID:27474069 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase decreases response to substance ISO MTHFD2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation
ISO acadesine promotes the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein] CTD PMID:33002460 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP artesunate inhibits the reaction [Glucose results in increased expression of MYD88 protein] CTD PMID:30031708 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Naca nascent polypeptide associated complex subunit alpha decreases response to substance ISO NACA mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 7:468,862...481,992
Ensembl chr 7:469,723...481,992
JBrowse link
G Nckap1 NCK-associated protein 1 increases response to substance ISO NCKAP1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 3:65,417,450...65,491,769
Ensembl chr 3:65,417,453...65,492,217
JBrowse link
G Ncoa4 nuclear receptor coactivator 4 multiple interactions
decreases expression
ISO Chloroquine inhibits the reaction [Artesunate results in decreased expression of NCOA4 mRNA]
Artesunate results in decreased expression of NCOA4 mRNA; Artesunate results in decreased expression of NCOA4 protein
CTD PMID:30551460 NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,556
Ensembl chr16:7,366,542...7,409,556
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization ISO artesunate affects the localization of NFE2L2 protein CTD PMID:26340163 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP artesunate inhibits the reaction [Glucose results in increased expression of NLRP3 protein] CTD PMID:30031708 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO Artesunate results in increased cleavage of PARP1 protein
3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; acadesine promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]
CTD PMID:24704559 PMID:33002460 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein] CTD PMID:29031619 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pgr progesterone receptor multiple interactions ISO artesunate binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 mRNA; [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 protein CTD PMID:30551460 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP artesunate inhibits the reaction [Ethanol results in increased expression of RELA protein]; artesunate inhibits the reaction [Glucose results in increased phosphorylation of RELA protein] CTD PMID:27474069 PMID:30031708 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rpa2 replication protein A2 increases phosphorylation ISO Artesunate results in increased phosphorylation of RPA2 protein CTD PMID:31664825 NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350
JBrowse link
G Rpl41 ribosomal protein L41 decreases response to substance ISO RPL41 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 7:977,885...978,965 JBrowse link
G Rpl6 ribosomal protein L6 decreases response to substance ISO RPL6 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921
JBrowse link
G Rpl7 ribosomal protein L7 decreases response to substance ISO RPL7 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 5:3,217,184...3,220,192 JBrowse link
G Rps12 ribosomal protein S12 decreases response to substance ISO RPS12 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:21,680,854...21,683,010
Ensembl chr 1:21,680,852...21,683,014
JBrowse link
G Rps15a ribosomal protein S15a decreases response to substance ISO RPS15A mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:172,420,151...172,427,021
Ensembl chr 1:172,419,761...172,426,995
JBrowse link
G Rps6 ribosomal protein S6 decreases response to substance ISO RPS6 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Slc25a19 solute carrier family 25 member 19 decreases response to substance ISO SLC25A19 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:100,853,554...100,867,517
Ensembl chr10:100,847,168...100,867,447
JBrowse link
G Sp1 Sp1 transcription factor decreases expression ISO artesunate results in decreased expression of SP1 protein CTD PMID:19513562 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression
ISO Chloroquine inhibits the reaction [Artesunate results in decreased expression of SQSTM1 protein]
Artesunate results in decreased expression of SQSTM1 mRNA; Artesunate results in decreased expression of SQSTM1 protein
CTD PMID:30551460 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Srsf2 serine and arginine rich splicing factor 2 decreases response to substance ISO SRSF2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression
multiple interactions
ISO Artesunate results in increased expression of TIMP1 mRNA
Chloroquine inhibits the reaction [Artesunate results in increased expression of TIMP1 mRNA]
CTD PMID:30551460 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP artesunate inhibits the reaction [Glucose results in increased expression of TLR4 protein] CTD PMID:30031708 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP artesunate inhibits the reaction [Ethanol results in increased expression of TNF protein]; artesunate inhibits the reaction [Glucose results in increased expression of TNF mRNA]; artesunate inhibits the reaction [Glucose results in increased secretion of TNF protein] CTD PMID:27474069 PMID:30031708 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO Artesunate results in increased expression of TP53 protein
Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein]
CTD PMID:33259807 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 affects response to substance
multiple interactions
ISO TPT1 protein affects the susceptibility to artesunate
Artesunate binds to and results in decreased expression of TPT1 protein; Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein]
CTD PMID:15878303 PMID:33259807 NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625
JBrowse link
G Tufm Tu translation elongation factor, mitochondrial decreases response to substance ISO TUFM mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 increases phosphorylation
multiple interactions
ISO Artesunate results in increased phosphorylation of ULK1 protein
acadesine promotes the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]
CTD PMID:33002460 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of VEGFA protein] CTD PMID:29031619 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Yy1 YY1 transcription factor decreases expression ISO artesunate results in decreased expression of YY1 protein CTD PMID:19513562 NCBI chr 6:127,706,739...127,731,907
Ensembl chr 6:127,707,596...127,732,747
JBrowse link
G Zbtb4 zinc finger and BTB domain containing 4 increases response to substance ISO ZBTB4 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:54,480,698...54,501,492
Ensembl chr10:54,485,071...54,501,492
JBrowse link
diethyl malate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle affects expression ISO diethyl malate affects the expression of ACTA2 mRNA CTD PMID:24814887 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Actc1 actin, alpha, cardiac muscle 1 affects expression ISO diethyl malate affects the expression of ACTC1 mRNA CTD PMID:24814887 NCBI chr 3:100,811,987...100,817,523
Ensembl chr 3:100,811,987...100,817,523
JBrowse link
G Actn3 actinin alpha 3 affects expression ISO diethyl malate affects the expression of ACTN3 mRNA CTD PMID:24814887 NCBI chr 1:202,159,081...202,175,012
Ensembl chr 1:202,159,082...202,175,012
JBrowse link
G Adcy1 adenylate cyclase 1 affects expression ISO diethyl malate affects the expression of ADCY1 mRNA CTD PMID:24814887 NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) affects expression ISO diethyl malate affects the expression of ADH1 mRNA CTD PMID:24814887 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
JBrowse link
G Agt angiotensinogen affects expression ISO diethyl malate affects the expression of AGT mRNA CTD PMID:24814887 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G C3 complement C3 affects expression ISO diethyl malate affects the expression of C3 mRNA CTD PMID:24814887 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 affects expression ISO diethyl malate affects the expression of CACNB2 mRNA CTD PMID:24814887 NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106
JBrowse link
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 affects expression ISO diethyl malate affects the expression of CACNB4 mRNA CTD PMID:24814887 NCBI chr 3:36,906,771...37,169,191
Ensembl chr 3:36,910,427...37,168,944
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions
affects expression
ISO S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CAMK2A mRNA] CTD PMID:24814887 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 affects expression ISO diethyl malate affects the expression of CCL20 mRNA CTD PMID:24814887 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Ccl6 C-C motif chemokine ligand 6 affects expression ISO diethyl malate affects the expression of CCL6 mRNA CTD PMID:24814887 NCBI chr10:68,381,179...68,385,811
Ensembl chr10:68,380,188...68,384,001
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 affects expression ISO diethyl malate affects the expression of CCL7 mRNA CTD PMID:24814887 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
JBrowse link
G Col11a1 collagen type XI alpha 1 chain affects expression ISO diethyl malate affects the expression of COL11A1 mRNA CTD PMID:24814887 NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853
JBrowse link
G Col2a1 collagen type II alpha 1 chain affects expression ISO diethyl malate affects the expression of COL2A1 mRNA CTD PMID:24814887 NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Col3a1 collagen type III alpha 1 chain affects expression ISO diethyl malate affects the expression of COL3A1 mRNA CTD PMID:24814887 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Col6a1 collagen type VI alpha 1 chain affects expression ISO diethyl malate affects the expression of COL6A1 mRNA CTD PMID:24814887 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597
JBrowse link
G Comp cartilage oligomeric matrix protein affects expression ISO diethyl malate affects the expression of COMP mRNA CTD PMID:24814887 NCBI chr16:19,047,206...19,055,584
Ensembl chr16:19,047,207...19,055,845
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 affects expression
multiple interactions
ISO diethyl malate affects the expression of CXCL12 mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CXCL12 mRNA]
CTD PMID:24814887 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 affects expression ISO diethyl malate affects the expression of CXCL1 mRNA CTD PMID:24814887 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 affects expression ISO diethyl malate affects the expression of CYP2J9 mRNA CTD PMID:24814887 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Dapk2 death-associated protein kinase 2 affects expression ISO diethyl malate affects the expression of DAPK2 mRNA CTD PMID:24814887 NCBI chr 8:66,706,536...66,825,567
Ensembl chr 8:66,706,609...66,825,567
JBrowse link
G Ddx58 DEXD/H-box helicase 58 affects expression ISO diethyl malate affects the expression of DDX58 mRNA CTD PMID:24814887 NCBI chr 5:55,321,229...55,369,947
Ensembl chr 5:55,321,235...55,370,819
JBrowse link
G Dhrs3 dehydrogenase/reductase 3 affects expression ISO diethyl malate affects the expression of DHRS3 mRNA CTD PMID:24814887 NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417
JBrowse link
G Dhx58 DEXH-box helicase 58 affects expression ISO diethyl malate affects the expression of DHX58 mRNA CTD PMID:24814887 NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525
JBrowse link
G Edar ectodysplasin-A receptor affects expression ISO diethyl malate affects the expression of EDAR mRNA CTD PMID:24814887 NCBI chr20:26,587,836...26,666,543
Ensembl chr20:26,587,839...26,666,494
JBrowse link
G Ednra endothelin receptor type A affects expression ISO diethyl malate affects the expression of EDNRA mRNA CTD PMID:24814887 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
JBrowse link
G Epas1 endothelial PAS domain protein 1 affects expression ISO diethyl malate affects the expression of EPAS1 mRNA CTD PMID:24814887 NCBI chr 6:7,790,236...7,871,246
Ensembl chr 6:7,790,647...7,871,228
JBrowse link
G Epha7 Eph receptor A7 affects expression ISO diethyl malate affects the expression of EPHA7 mRNA CTD PMID:24814887 NCBI chr 5:42,975,353...43,128,703
Ensembl chr 5:42,975,405...43,127,112
JBrowse link
G Ephb2 Eph receptor B2 affects expression ISO diethyl malate affects the expression of EPHB2 mRNA CTD PMID:24814887 NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059
JBrowse link
G Ephb6 Eph receptor B6 affects expression ISO diethyl malate affects the expression of EPHB6 mRNA CTD PMID:24814887 NCBI chr 4:70,491,973...70,507,230
Ensembl chr 4:70,491,973...70,507,230
JBrowse link
G Fgf10 fibroblast growth factor 10 affects expression ISO diethyl malate affects the expression of FGF10 mRNA CTD PMID:24814887 NCBI chr 2:50,801,897...50,875,428
Ensembl chr 2:50,800,992...50,876,866
JBrowse link
G Fgf18 fibroblast growth factor 18 multiple interactions
affects expression
ISO S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of FGF18 mRNA] CTD PMID:24814887 NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 affects expression ISO diethyl malate affects the expression of FGFR2 mRNA CTD PMID:24814887 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
JBrowse link
G Fst follistatin affects expression ISO diethyl malate affects the expression of FST mRNA CTD PMID:24814887 NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571
JBrowse link
G Fzd2 frizzled class receptor 2 affects expression ISO diethyl malate affects the expression of FZD2 mRNA CTD PMID:24814887 NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334
JBrowse link
G Fzd7 frizzled class receptor 7 affects expression ISO diethyl malate affects the expression of FZD7 mRNA CTD PMID:24814887 NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit affects expression ISO diethyl malate affects the expression of GCLC mRNA CTD PMID:24814887 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
affects expression
ISO S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GCLM mRNA] CTD PMID:24814887 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Ggt6 gamma-glutamyl transferase 6 affects expression ISO diethyl malate affects the expression of GGT6 mRNA CTD PMID:24814887 NCBI chr10:57,052,025...57,054,502
Ensembl chr10:57,051,825...57,067,260
JBrowse link
G Gli2 GLI family zinc finger 2 affects expression ISO diethyl malate affects the expression of GLI2 mRNA CTD PMID:24814887 NCBI chr13:29,946,809...30,163,901
Ensembl chr13:29,946,809...30,163,574
JBrowse link
G Gnao1 G protein subunit alpha o1 affects expression ISO diethyl malate affects the expression of GNAO1 mRNA CTD PMID:24814887 NCBI chr19:11,034,874...11,192,502
Ensembl chr19:11,035,956...11,192,493
JBrowse link
G Gng7 G protein subunit gamma 7 affects expression ISO diethyl malate affects the expression of GNG7 mRNA CTD PMID:24814887 NCBI chr 7:8,697,458...8,761,239
Ensembl chr 7:8,697,521...8,761,240
JBrowse link
G Gsr glutathione-disulfide reductase affects expression ISO diethyl malate affects the expression of GSR mRNA CTD PMID:24814887 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gss glutathione synthetase multiple interactions
affects expression
ISO S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSS mRNA] CTD PMID:24814887 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 affects expression
multiple interactions
ISO diethyl malate affects the expression of GSTA1 mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSTA1 mRNA]
CTD PMID:24814887 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 affects expression
multiple interactions
ISO diethyl malate affects the expression of GSTA3 mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSTA3 mRNA]
CTD PMID:24814887 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
JBrowse link
G Gsta6 glutathione S-transferase alpha 6 affects expression
multiple interactions
ISO diethyl malate affects the expression of GSTA1 mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSTA1 mRNA]
CTD PMID:24814887 NCBI chr 9:23,743,262...23,806,260
Ensembl chr 9:23,744,288...23,801,131
JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 affects expression ISO diethyl malate affects the expression of GUCY1A1 mRNA CTD PMID:24814887 NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 affects expression ISO diethyl malate affects the expression of GUCY1B1 mRNA CTD PMID:24814887 NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916
JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase affects expression ISO diethyl malate affects the expression of HCK mRNA CTD PMID:24814887 NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693
JBrowse link
G Hgf hepatocyte growth factor affects expression ISO diethyl malate affects the expression of HGF mRNA CTD PMID:24814887 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Igf1 insulin-like growth factor 1 affects expression ISO diethyl malate affects the expression of IGF1 mRNA CTD PMID:24814887 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il15 interleukin 15 affects expression ISO diethyl malate affects the expression of IL15 mRNA CTD PMID:24814887 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il18 interleukin 18 affects expression ISO diethyl malate affects the expression of IL18 mRNA CTD PMID:24814887 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Irag1 inositol 1,4,5-triphosphate receptor associated 1 affects expression ISO diethyl malate affects the expression of IRAG1 mRNA CTD PMID:24814887 NCBI chr 1:164,981,716...165,094,232
Ensembl chr 1:164,981,716...165,094,176
JBrowse link
G Irf7 interferon regulatory factor 7 affects expression ISO diethyl malate affects the expression of IRF7 mRNA CTD PMID:24814887 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier affects expression ISO diethyl malate affects the expression of ISG15 mRNA CTD PMID:24814887 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
JBrowse link
G Itga11 integrin subunit alpha 11 affects expression ISO diethyl malate affects the expression of ITGA11 mRNA CTD PMID:24814887 NCBI chr 8:63,145,950...63,254,717
Ensembl chr 8:63,146,001...63,254,407
JBrowse link
G Itga3 integrin subunit alpha 3 affects expression ISO diethyl malate affects the expression of ITGA3 mRNA CTD PMID:24814887 NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118
JBrowse link
G Kcnmb4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 affects expression ISO diethyl malate affects the expression of KCNMB4 mRNA CTD PMID:24814887 NCBI chr 7:52,066,145...52,119,098
Ensembl chr 7:52,066,136...52,119,278
JBrowse link
G Lama1 laminin subunit alpha 1 affects expression ISO diethyl malate affects the expression of LAMA1 mRNA CTD PMID:24814887 NCBI chr 9:107,692,770...107,816,847
Ensembl chr 9:107,692,770...107,817,478
JBrowse link
G Lama4 laminin subunit alpha 4 affects expression ISO diethyl malate affects the expression of LAMA4 mRNA CTD PMID:24814887 NCBI chr20:42,392,268...42,533,347
Ensembl chr20:42,392,268...42,533,347
JBrowse link
G LOC100909797 RT1 class I histocompatibility antigen, AA alpha chain-like affects expression ISO diethyl malate affects the expression of H2-M3 mRNA CTD PMID:24814887
G Mapk1 mitogen activated protein kinase 1 affects phosphorylation
multiple interactions
ISO diethyl malate affects the phosphorylation of MAPK1 protein
S-ethyl glutathione inhibits the reaction [diethyl malate affects the phosphorylation of MAPK1 protein]
CTD PMID:24814887 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects phosphorylation
multiple interactions
ISO diethyl malate affects the phosphorylation of MAPK3 protein
S-ethyl glutathione inhibits the reaction [diethyl malate affects the phosphorylation of MAPK3 protein]
CTD PMID:24814887 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Myl9 myosin light chain 9 affects expression ISO diethyl malate affects the expression of MYL9 mRNA CTD PMID:24814887 NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333
JBrowse link
G Odc1 ornithine decarboxylase 1 affects expression ISO diethyl malate affects the expression of ODC1 mRNA CTD PMID:24814887 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Pdgfb platelet derived growth factor subunit B affects expression
multiple interactions
ISO diethyl malate affects the expression of PDGFB mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of PDGFB mRNA]
CTD PMID:24814887 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pdgfd platelet derived growth factor D affects expression ISO diethyl malate affects the expression of PDGFD mRNA CTD PMID:24814887 NCBI chr 8:3,488,448...3,722,395
Ensembl chr 8:3,488,423...3,722,395
JBrowse link
G Pf4 platelet factor 4 affects expression ISO diethyl malate affects the expression of PF4 mRNA CTD PMID:24814887 NCBI chr14:17,298,438...17,299,148
Ensembl chr14:17,298,308...17,299,365
JBrowse link
G Pik3ip1 phosphoinositide-3-kinase interacting protein 1 affects expression ISO diethyl malate affects the expression of PIK3IP1 mRNA CTD PMID:24814887 NCBI chr14:78,203,539...78,216,616
Ensembl chr14:78,204,053...78,216,608
JBrowse link
G Plxnc1 plexin C1 affects expression ISO diethyl malate affects the expression of PLXNC1 mRNA CTD PMID:24814887 NCBI chr 7:29,390,038...29,543,985
Ensembl chr 7:29,390,048...29,543,779
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 affects expression ISO diethyl malate affects the expression of PRKG1 mRNA CTD PMID:24814887 NCBI chr 1:228,409,883...229,638,794
Ensembl chr 1:228,408,947...229,639,080
JBrowse link
G Ptgis prostaglandin I2 synthase affects expression ISO diethyl malate affects the expression of PTGIS mRNA CTD PMID:24814887 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451
JBrowse link
G Ramp2 receptor activity modifying protein 2 affects expression ISO diethyl malate affects the expression of RAMP2 mRNA CTD PMID:24814887 NCBI chr10:86,187,366...86,190,692
Ensembl chr10:86,188,812...86,231,829
JBrowse link
G Rgs3 regulator of G-protein signaling 3 affects expression ISO diethyl malate affects the expression of RGS3 mRNA CTD PMID:24814887 NCBI chr 5:76,022,038...76,161,895
Ensembl chr 5:76,022,001...76,161,894
JBrowse link
G Runx1t1 RUNX1 partner transcriptional co-repressor 1 affects expression ISO diethyl malate affects the expression of RUNX1T1 mRNA CTD PMID:24814887 NCBI chr 5:27,187,674...27,338,070
Ensembl chr 5:27,187,551...27,335,592
JBrowse link
G Sema3b semaphorin 3B affects expression ISO diethyl malate affects the expression of SEMA3B mRNA CTD PMID:24814887 NCBI chr 8:108,271,663...108,280,326
Ensembl chr 8:108,271,666...108,282,919
JBrowse link
G Sema4g semaphorin 4G affects expression ISO diethyl malate affects the expression of SEMA4G mRNA CTD PMID:24814887 NCBI chr 1:243,849,979...243,865,343
Ensembl chr 1:243,853,854...243,865,341
JBrowse link
G Sema5a semaphorin 5A affects expression ISO diethyl malate affects the expression of SEMA5A mRNA CTD PMID:24814887 NCBI chr 2:83,309,843...83,741,084
Ensembl chr 2:83,309,843...83,741,084
JBrowse link
G Stat1 signal transducer and activator of transcription 1 affects expression ISO diethyl malate affects the expression of STAT1 mRNA CTD PMID:24814887 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Tgfb2 transforming growth factor, beta 2 affects expression
multiple interactions
ISO diethyl malate affects the expression of TGFB2 mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of TGFB2 mRNA]
CTD PMID:24814887 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Thbs1 thrombospondin 1 affects expression ISO diethyl malate affects the expression of THBS1 mRNA CTD PMID:24814887 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Thbs2 thrombospondin 2 affects expression ISO diethyl malate affects the expression of THBS2 mRNA CTD PMID:24814887 NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789
JBrowse link
G Tnc tenascin C affects expression ISO diethyl malate affects the expression of TNC mRNA CTD PMID:24814887 NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B affects expression ISO diethyl malate affects the expression of TNFRSF11B mRNA CTD PMID:24814887 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Tnnt1 troponin T1, slow skeletal type affects expression ISO diethyl malate affects the expression of TNNT1 mRNA CTD PMID:24814887 NCBI chr 1:69,306,362...69,316,721
Ensembl chr 1:69,306,362...69,316,721
JBrowse link
G Tslp thymic stromal lymphopoietin affects expression ISO diethyl malate affects the expression of TSLP mRNA CTD PMID:24814887 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
JBrowse link
hydrocortisone succinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [hydrocortisone hemisuccinate co-treated with Dimethyl Sulfoxide] results in increased expression of CYP1A2 CTD PMID:18347083 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [hydrocortisone hemisuccinate co-treated with Dimethyl Sulfoxide] results in increased expression of CYP3A4 CTD PMID:18347083 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G F2 coagulation factor II affects expression ISO hydrocortisone hemisuccinate affects the expression of F2 protein CTD PMID:12542493 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G Il18 interleukin 18 decreases secretion ISO hydrocortisone hemisuccinate results in decreased secretion of IL18 protein CTD PMID:20421217 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta decreases secretion ISO hydrocortisone hemisuccinate results in decreased secretion of IL1B protein CTD PMID:20421217 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 decreases secretion ISO hydrocortisone hemisuccinate results in decreased secretion of IL6 protein CTD PMID:20421217 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO hydrocortisone hemisuccinate results in decreased secretion of TNF protein CTD PMID:20421217 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
malic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
decreases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of malic acid] CTD PMID:27469509 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
G Mdh1 malate dehydrogenase 1 increases expression ISO malic acid deficiency results in increased expression of MDH1 mRNA CTD PMID:26811028 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO [[NR1H4 protein co-treated with Dietary Fats] results in increased susceptibility to caffeic acid phenethyl ester] which results in increased abundance of malic acid CTD PMID:28223344 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO malic acid results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
methylprednisolone succinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces2h carboxylesterase 2H multiple interactions
increases hydrolysis
EXP Dexamethasone promotes the reaction [CES2 protein results in increased hydrolysis of Methylprednisolone Hemisuccinate] CTD PMID:15794950 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
monomethyl succinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO [alpha-ketoisocaproic acid co-treated with monomethyl succinate] inhibits the reaction [Palmitates results in decreased expression of SLC2A4 mRNA] CTD PMID:21802492 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO monomethyl succinate inhibits the reaction [bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II) results in increased expression of TP53 protein] CTD PMID:21548882 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
oxaloacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Got1 glutamic-oxaloacetic transaminase 1 increases expression ISO Oxaloacetic Acid results in increased expression of GOT1 mRNA CTD PMID:26811028 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
JBrowse link
G Mdh1 malate dehydrogenase 1 increases expression ISO Oxaloacetic Acid results in increased expression of MDH1 protein CTD PMID:26811028 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II increases expression ISO Oxaloacetic Acid results in increased expression of COX2 mRNA; Oxaloacetic Acid results in increased expression of COX2 protein CTD PMID:26811028 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Oxaloacetic Acid results in increased expression of PPARGC1A mRNA; Oxaloacetic Acid results in increased expression of PPARGC1A protein CTD PMID:23056435 PMID:26811028 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ppargc1b PPARG coactivator 1 beta increases expression ISO Oxaloacetic Acid results in increased expression of PPARGC1B protein CTD PMID:26811028 NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194
JBrowse link
G Pprc1 PPARG related coactivator 1 increases expression ISO Oxaloacetic Acid results in increased expression of PPRC1 mRNA; Oxaloacetic Acid results in increased expression of PPRC1 protein CTD PMID:26811028 NCBI chr 1:244,901,985...244,918,587
Ensembl chr 1:244,902,179...244,918,587
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Oxaloacetic Acid results in increased expression of and results in increased phosphorylation of SIRT1 protein CTD PMID:26811028 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Oxaloacetic Acid results in increased expression of TFAM mRNA CTD PMID:26811028 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
JBrowse link
SAICAR term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pkm pyruvate kinase M1/2 multiple interactions ISO Glucose deficiency promotes the reaction [SAICAR binds to and results in increased activity of PKM protein] CTD PMID:23086999 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
JBrowse link
sarpogrelate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 multiple interactions ISO sarpogrelate inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; sarpogrelate metabolite inhibits the reaction [Serotonin results in increased expression of ACAT1 protein] CTD PMID:16157345 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO sarpogrelate results in increased expression of ADIPOQ protein CTD PMID:18235151 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions ISO sarpogrelate inhibits the reaction [Prazosin binds to ADRA1A protein] CTD PMID:11937776 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Adra1b adrenoceptor alpha 1B multiple interactions ISO sarpogrelate inhibits the reaction [Prazosin binds to ADRA1B protein] CTD PMID:11937776 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
JBrowse link
G Adra1d adrenoceptor alpha 1D multiple interactions ISO sarpogrelate inhibits the reaction [Prazosin binds to ADRA1D protein] CTD PMID:11937776 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein] CTD PMID:22975078 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 affects expression EXP sarpogrelate affects the expression of ATP2A2 mRNA; sarpogrelate affects the expression of ATP2A2 protein CTD PMID:18088389 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of BAX protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of BAX protein] CTD PMID:34560070 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; sarpogrelate inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein] CTD PMID:34560070 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein] CTD PMID:34560070 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein] CTD PMID:34560070 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
ISO sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CCL2 protein]
sarpogrelate results in decreased expression of CCL2 protein
CTD PMID:18235151 PMID:26824242 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity
multiple interactions
ISO sarpogrelate metabolite results in decreased activity of CYP2D6 protein; sarpogrelate results in decreased activity of CYP2D6 protein
sarpogrelate inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]; sarpogrelate metabolite inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]
CTD PMID:24167220 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Ddc dopa decarboxylase multiple interactions ISO sarpogrelate inhibits the reaction [Cisplatin results in increased expression of DDC protein] CTD PMID:34560070 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
JBrowse link
G Fabp1 fatty acid binding protein 1 multiple interactions ISO sarpogrelate inhibits the reaction [Oxygen deficiency results in increased expression of FABP1 protein] CTD PMID:24107419 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B multiple interactions EXP sarpogrelate inhibits the reaction [Iodocyanopindolol binds to HTR1B protein]; sarpogrelate metabolite inhibits the reaction [Iodocyanopindolol binds to HTR1B protein] CTD PMID:8937629 NCBI chr 8:82,513,572...82,534,892
Ensembl chr 8:82,517,360...82,534,549
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
affects binding
ISO
EXP
sarpogrelate binds to and results in decreased activity of HTR2A protein; sarpogrelate binds to and results in decreased activity of HTR2A protein mutant form; sarpogrelate metabolite binds to and results in decreased activity of HTR2A protein
sarpogrelate binds to HTR2A protein; sarpogrelate metabolite binds to HTR2A protein
CTD PMID:8937629 PMID:16974069 PMID:17031071 PMID:19672037 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding ISO sarpogrelate binds to HTR2C protein CTD PMID:16880620 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO sarpogrelate inhibits the reaction [Glucose results in increased expression of ICAM1 protein] CTD PMID:23111892 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il18 interleukin 18 decreases expression ISO sarpogrelate results in decreased expression of IL18 protein CTD PMID:15080020 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased secretion of IL1B protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased secretion of IL1B protein]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of IL1B protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of IL1B protein]
CTD PMID:34560070 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO sarpogrelate inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein] CTD PMID:11076827 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO [sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein] CTD PMID:22975078 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein] CTD PMID:27097221 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of MAOA protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of MAOA protein] CTD PMID:34560070 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions EXP sarpogrelate inhibits the reaction [Oxygen deficiency results in increased expression of MMP13 mRNA] CTD PMID:25931318 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO sarpogrelate inhibits the reaction [Palmitic Acid results in increased activity of MTOR protein]; sarpogrelate inhibits the reaction [Serotonin results in increased activity of MTOR protein] CTD PMID:27133527 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP sarpogrelate promotes the reaction [Oxygen deficiency results in increased expression of NOS3 protein] CTD PMID:25931318 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PECAM1 protein] CTD PMID:27097221 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
JBrowse link
G Pln phospholamban affects expression EXP sarpogrelate affects the expression of PLN mRNA; sarpogrelate affects the expression of PLN protein CTD PMID:18088389 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP sarpogrelate inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of PTGS2 protein] CTD PMID:21262218 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein] CTD PMID:34560070 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Serpine2 serpin family E member 2 decreases expression
multiple interactions
ISO sarpogrelate results in decreased expression of SERPINE2 mRNA
sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]
CTD PMID:24107419 PMID:27097221 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826
JBrowse link
G Slc2a1 solute carrier family 2 member 1 affects expression EXP sarpogrelate affects the expression of SLC2A1 protein CTD PMID:21183729 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc2a4 solute carrier family 2 member 4 affects expression EXP sarpogrelate affects the expression of SLC2A4 protein CTD PMID:21183729 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Sorl1 sortilin related receptor 1 multiple interactions ISO sarpogrelate inhibits the reaction [Serotonin results in increased expression of SORL1 mRNA] CTD PMID:24650663 NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased phosphorylation of STAT3 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased phosphorylation of STAT3 protein] CTD PMID:34560070 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein] CTD PMID:24107419 PMID:27097221 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased secretion of TNF protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased secretion of TNF protein]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of TNF protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of TNF protein]
CTD PMID:34560070 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tph1 tryptophan hydroxylase 1 multiple interactions ISO sarpogrelate inhibits the reaction [Cisplatin results in increased expression of TPH1 protein] CTD PMID:34560070 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of sarpogrelate metabolite CTD PMID:23704698 NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of sarpogrelate metabolite CTD PMID:23704698 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO sarpogrelate inhibits the reaction [[Glucose co-treated with Serotonin] results in increased expression of VCAM1 protein] CTD PMID:22785018 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
succinylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase increases response to substance
increases metabolic processing
increases hydrolysis
affects hydrolysis
affects response to substance
decreases hydrolysis
decreases abundance
multiple interactions
ISO BCHE gene mutant form results in increased susceptibility to Succinylcholine; BCHE gene polymorphism results in increased susceptibility to Succinylcholine; BCHE protein mutant form results in increased susceptibility to Succinylcholine
BCHE protein results in increased metabolism of Succinylcholine
BCHE protein results in increased hydrolysis of Succinylcholine
BCHE protein mutant form affects the hydrolysis of Succinylcholine
BCHE affects the susceptibility to Succinylcholine; BCHE gene mutant form affects the susceptibility to Succinylcholine; BCHE gene polymorphism affects the susceptibility to Succinylcholine; BCHE protein affects the susceptibility to Succinylcholine
BCHE protein mutant form results in decreased hydrolysis of Succinylcholine
BCHE protein results in decreased abundance of Succinylcholine
[Dichlorvos results in decreased activity of BCHE protein] which results in increased susceptibility to Succinylcholine; Insecticides inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine]; Organophosphorus Compounds inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine]; Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]
CTD PMID:726855 PMID:900467 PMID:987736 PMID:1058931 PMID:1147298 More... NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:14645658 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:14645658 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Mb myoglobin increases secretion ISO Succinylcholine results in increased secretion of MB protein CTD PMID:8217179 NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
JBrowse link
suxibuzone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pklr pyruvate kinase L/R decreases activity EXP suxibuzone results in decreased activity of PKLR protein CTD PMID:3107799 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
JBrowse link
thiomalic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Endog endonuclease G multiple interactions EXP [Hydrogen Peroxide co-treated with 2-thiomalic acid] affects the localization of ENDOG protein CTD PMID:16407272 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases activity ISO 2-thiomalic acid results in decreased activity of GPX1 protein CTD PMID:21892612 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 2-thiomalic acid promotes the reaction [Asbestos, Crocidolite results in increased secretion of TNF protein] CTD PMID:10486238 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      application 19747
        pharmaceutical 19619
          drug 19619
            anti-ulcer drug 796
              succinic acid 226
                (2S)-2-isopropyl-3-oxosuccinic acid 0
                (R)-2-(phosphonomethyl)malic acid 0
                (R)-2-ethylmalic acid 0
                (R)-3,3-dimethylmalic acid 0
                (carboxymethoxy)succinic acid 0
                1-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine 0
                11-deoxycorticosterone-21-hemisuccinate 0
                11alpha-hydroxyprogesterone hemisuccinate + 0
                2,2-dimethylsuccinic acid 0
                2-(acetamidomethylidene)succinic acid 0
                2-(phosphinomethylidene)succinic acid 0
                2-benzylsuccinic acid + 0
                2-chlorosuccinic acid 0
                2-hydroxy-3-oxosuccinic acid + 0
                2-isopropylmalic acid + 0
                2-methyl-3-oxosuccinic acid + 0
                2-methylene-3-methylsuccinic acid 0
                2-propylmalic acid + 0
                3-(acetamidomethylidene)-2-(hydroxymethyl)succinic acid 0
                3-carboxypropanoyl group 0
                3-ethylmalic acid 0
                3-hydroxy-2-isopropyl-4-methoxy-4-oxobutanoate 0
                3-hydroxy-2-isopropyl-4-methoxy-4-oxobutanoic acid 0
                3-isopropylmalic acid + 0
                3-methylmalic acid + 0
                3-propylmalic acid 0
                4-(6-hydroxypyridin-3-yl)-4-oxobutyric acid 0
                4-\{[6-endo-amino-6-exo-benzoyl-5-exo-phenylnorbornan-2-yl]oxy\}-4-oxobutanoic acid 0
                4-methoxy-4-oxo-3-phenylbutanoic acid 0
                6beta-hydroxyprogesterone hemisuccinate 0
                N(6)-(1,2-dicarboxyethyl)-AMP 0
                N-succinyl-L-glutamic 5-semialdehyde 0
                SAICAR 1
                bromosuccinic acid 0
                carboxyfentanyl 0
                citramalic acid + 0
                dioxosuccinic acid 0
                ethyl 3-methylbutyl butanedioate 0
                iminoaspartic acid 0
                itaconic acid + 0
                malic acid + 93
                methoxysuccinyl-Ala-Ala-Pro-Ala chloromethyl ketone 0
                methoxysuccinyl-Ala-Ala-Pro-Val chloromethyl ketone 0
                oxaloacetic acid + 8
                phenyl [1-(N-succinylamino)pentyl]phosphonate 0
                prednisolone succinate 0
                succinamic acid + 0
                succinate ester + 118
                succinic anhydride + 0
                succinyl group 0
                succinyladenosine 0
                thiomalic acid + 3
                trans-2,3-epoxysuccinic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic group 18943
                              organic divalent group 18928
                                organodiyl group 18928
                                  carbonyl group 18877
                                    carbonyl compound 18877
                                      dicarboxylic acids and O-substituted derivatives 10383
                                        dicarboxylic acid 10375
                                          alpha,omega-dicarboxylic acid 2806
                                            succinic acid 226
                                              (2S)-2-isopropyl-3-oxosuccinic acid 0
                                              (R)-2-(phosphonomethyl)malic acid 0
                                              (R)-2-ethylmalic acid 0
                                              (R)-3,3-dimethylmalic acid 0
                                              (carboxymethoxy)succinic acid 0
                                              1-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine 0
                                              11-deoxycorticosterone-21-hemisuccinate 0
                                              11alpha-hydroxyprogesterone hemisuccinate + 0
                                              2,2-dimethylsuccinic acid 0
                                              2-(acetamidomethylidene)succinic acid 0
                                              2-(phosphinomethylidene)succinic acid 0
                                              2-benzylsuccinic acid + 0
                                              2-chlorosuccinic acid 0
                                              2-hydroxy-3-oxosuccinic acid + 0
                                              2-isopropylmalic acid + 0
                                              2-methyl-3-oxosuccinic acid + 0
                                              2-methylene-3-methylsuccinic acid 0
                                              2-propylmalic acid + 0
                                              3-(acetamidomethylidene)-2-(hydroxymethyl)succinic acid 0
                                              3-carboxypropanoyl group 0
                                              3-ethylmalic acid 0
                                              3-hydroxy-2-isopropyl-4-methoxy-4-oxobutanoate 0
                                              3-hydroxy-2-isopropyl-4-methoxy-4-oxobutanoic acid 0
                                              3-isopropylmalic acid + 0
                                              3-methylmalic acid + 0
                                              3-propylmalic acid 0
                                              4-(6-hydroxypyridin-3-yl)-4-oxobutyric acid 0
                                              4-\{[6-endo-amino-6-exo-benzoyl-5-exo-phenylnorbornan-2-yl]oxy\}-4-oxobutanoic acid 0
                                              4-methoxy-4-oxo-3-phenylbutanoic acid 0
                                              6beta-hydroxyprogesterone hemisuccinate 0
                                              N(6)-(1,2-dicarboxyethyl)-AMP 0
                                              N-succinyl-L-glutamic 5-semialdehyde 0
                                              SAICAR 1
                                              bromosuccinic acid 0
                                              carboxyfentanyl 0
                                              citramalic acid + 0
                                              dioxosuccinic acid 0
                                              ethyl 3-methylbutyl butanedioate 0
                                              iminoaspartic acid 0
                                              itaconic acid + 0
                                              malic acid + 93
                                              methoxysuccinyl-Ala-Ala-Pro-Ala chloromethyl ketone 0
                                              methoxysuccinyl-Ala-Ala-Pro-Val chloromethyl ketone 0
                                              oxaloacetic acid + 8
                                              phenyl [1-(N-succinylamino)pentyl]phosphonate 0
                                              prednisolone succinate 0
                                              succinamic acid + 0
                                              succinate ester + 118
                                              succinic anhydride + 0
                                              succinyl group 0
                                              succinyladenosine 0
                                              thiomalic acid + 3
                                              trans-2,3-epoxysuccinic acid 0
paths to the root