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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:staurosporine
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Accession:CHEBI:15738 term browser browse the term
Definition:An indolocarbazole alkaloid that has formula C28H26N4O3.
Synonyms:related_synonym: (5S,6R,7R,9R)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one;   AM-2282;   Formula=C28H26N4O3;   InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1;   InChIKey=HKSZLNNOFSGOKW-FYTWVXJKSA-N;   SMILES=CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)N1C3=C(C=CC=C3)C3=C1C1=C(C4=C(C=CC=C4)N21)C1=C3CNC1=O;   STS;   Staurosporin;   antibiotic AM 2282
 alt_id: CHEBI:15106;   CHEBI:45788;   CHEBI:9252
 xref: CAS:62996-74-1;   DrugBank:DB02010;   KEGG:C02079;   KNApSAcK:C00018127;   LINCS:LSM-1103
 xref_mesh: MESH:D019311
 xref: PDBeChem:STU;   PMID:15613975;   PMID:15682296;   PMID:18478334;   PMID:22363408;   PMID:32800439;   PMID:34428735;   Wikipedia:Staurosporine
 cyclic_relationship: is_conjugate_base_of CHEBI:57491



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staurosporine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Staurosporine results in decreased activity of ABCB11 protein CTD PMID:20829430 PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Ache acetylcholinesterase multiple interactions
increases expression
increases activity
ISO ACHE protein affects the susceptibility to [Staurosporine results in increased activity of CASP9 protein]
Staurosporine results in increased expression of ACHE protein alternative form
Staurosporine results in increased activity of ACHE protein
CTD PMID:20338155 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Adm adrenomedullin decreases expression ISO Staurosporine results in decreased expression of ADM mRNA CTD PMID:19253104 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]
Staurosporine results in increased phosphorylation of AKT1 protein
Staurosporine promotes the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]
CTD PMID:11306697 PMID:15177934 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Staurosporine inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; Staurosporine promotes the reaction [PSEN2 protein mutant form results in increased expression of APP protein] CTD PMID:12556443 PMID:18001288 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Ar androgen receptor multiple interactions ISO Staurosporine binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Atg12 autophagy related 12 affects response to substance ISO ATG12 protein affects the susceptibility to Staurosporine CTD PMID:16497721 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
JBrowse link
G Atg7 autophagy related 7 affects response to substance ISO ATG7 protein affects the susceptibility to Staurosporine CTD PMID:16497721 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 decreases expression EXP Staurosporine results in decreased expression of ATP2A2 mRNA CTD PMID:10625299 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Bag3 BAG cochaperone 3 decreases response to substance
decreases expression
multiple interactions
ISO BAG3 protein results in decreased susceptibility to Staurosporine
Staurosporine results in decreased expression of BAG3 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Staurosporine results in increased degradation of BAG3 protein]; Staurosporine results in increased degradation of and results in increased ubiquitination of BAG3 protein
CTD PMID:19352495 NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858
JBrowse link
G Bag4 BAG cochaperone 4 decreases expression ISO Staurosporine results in decreased expression of BAG4 protein CTD PMID:19352495 NCBI chr16:66,288,678...66,305,893
Ensembl chr16:66,288,678...66,308,663
JBrowse link
G Bag6 BAG cochaperone 6 decreases expression ISO Staurosporine results in decreased expression of BAG6 protein CTD PMID:19352495 NCBI chr20:3,675,938...3,690,414
Ensembl chr20:3,675,938...3,688,657
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects localization
affects expression
increases expression
ISO
EXP
Silybin inhibits the reaction [Staurosporine promotes the reaction [Acetaldehyde results in increased expression of BAX protein]]; Staurosporine affects the folding of and results in increased activity of BAX protein; Staurosporine promotes the reaction [Acetaldehyde results in increased expression of BAX protein]; Staurosporine promotes the reaction [BID protein binds to BAX protein]; Staurosporine results in increased activity of and results in increased expression of BAX protein
Staurosporine affects the localization of BAX protein
Staurosporine affects the expression of BAX mRNA
Tacrine inhibits the reaction [Staurosporine results in increased expression of BAX protein]
CTD PMID:11296547 PMID:12579951 PMID:15961378 PMID:16007140 PMID:19552762 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Silybin inhibits the reaction [Staurosporine promotes the reaction [Acetaldehyde results in decreased expression of BCL2 protein]]; Staurosporine inhibits the reaction [Paclitaxel results in increased phosphorylation of BCL2 protein]; Staurosporine promotes the reaction [Acetaldehyde results in decreased expression of BCL2 protein] CTD PMID:15907805 PMID:35158046 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases response to substance
increases expression
affects expression
ISO
EXP
BCL2L1 protein results in decreased susceptibility to Staurosporine
Staurosporine results in increased expression of BCL2L1 protein alternative form
Staurosporine affects the expression of BCL2L1 mRNA
BCL2L1 gene mutant form results in decreased susceptibility to Staurosporine
CTD PMID:10679475 PMID:10970895 PMID:11296547 PMID:11468182 PMID:21256112 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Becn1 beclin 1 multiple interactions
decreases response to substance
ISO 3-methyladenine inhibits the reaction [BECN1 protein results in decreased susceptibility to Staurosporine] CTD PMID:16497721 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bid BH3 interacting domain death agonist increases expression
multiple interactions
ISO Staurosporine results in increased expression of BID protein
Staurosporine promotes the reaction [BID protein binds to BAX protein]
CTD PMID:19552762 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases response to substance ISO BIRC3 protein results in decreased susceptibility to Staurosporine CTD PMID:16144937 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Staurosporine results in decreased expression of BIRC5 protein CTD PMID:16225760 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B affects expression ISO Staurosporine affects the expression of BUB1B mRNA CTD PMID:15721199 NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547
JBrowse link
G Casp1 caspase 1 multiple interactions
increases activity
affects localization
ISO Nicotine affects the reaction [Staurosporine affects the localization of CASP1 protein]; Nicotine inhibits the reaction [Staurosporine results in increased activity of CASP1 protein] CTD PMID:16927020 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp2 caspase 2 increases cleavage ISO Staurosporine results in increased cleavage of CASP2 protein CTD PMID:10663630 PMID:26124276 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases cleavage
increases secretion
increases activity
ISO
EXP
Acetaminophen promotes the reaction [Staurosporine results in increased activity of CASP3 protein]; DOCK1 protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; ELMO1 protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; EOMES protein inhibits the reaction [Staurosporine results in increased expression of CASP3 protein modified form]; ginkgolide B inhibits the reaction [Staurosporine results in increased cleavage of CASP3 protein]; Lithium Chloride inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; Memantine inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]]; PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]; quinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [Staurosporine results in increased cleavage of CASP3 protein]; Rifampin inhibits the reaction [Staurosporine results in increased cleavage of CASP3 protein]; Staurosporine results in increased cleavage of and results in increased activity of CASP3 protein; Thiopental inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; Valproic Acid inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]
Staurosporine results in increased secretion of CASP3 protein
3-methyladenine promotes the reaction [Staurosporine results in increased cleavage of CASP3 protein]; EGF protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; HR protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; Ibuprofen inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; IGF1 protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; nimesulide inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; Sirolimus inhibits the reaction [Staurosporine results in increased cleavage of CASP3 protein]
HR protein affects the reaction [Staurosporine results in increased activity of CASP3 protein]; Staurosporine promotes the reaction [CASP3 protein results in increased cleavage of SPTAN1 protein]; TRP53 protein affects the reaction [HR protein affects the reaction [Staurosporine results in increased activity of CASP3 protein]]; VASP mutant form promotes the reaction [Staurosporine promotes the reaction [CASP3 protein results in increased cleavage of SPTAN1 protein]]
CTD PMID:10663630 PMID:11296547 PMID:12556443 PMID:12871656 PMID:15909127 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp6 caspase 6 increases cleavage ISO Staurosporine results in increased cleavage of CASP6 protein CTD PMID:26124276 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Casp7 caspase 7 multiple interactions
increases expression
increases cleavage
increases activity
EXP
ISO
EGF protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]; IGF1 protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]
Staurosporine results in increased expression of CASP7 protein modified form
Staurosporine results in increased cleavage of CASP7 protein
DOCK1 protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]; ELMO1 protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]; EOMES protein inhibits the reaction [Staurosporine results in increased expression of CASP7 protein modified form]
CTD PMID:16402917 PMID:18832097 PMID:19352495 PMID:19406941 PMID:21864672 More... NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
increases activity
ISO benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Staurosporine results in increased cleavage of CASP8 protein]; Staurosporine results in increased cleavage of and results in increased activity of CASP8 protein
Staurosporine results in increased activity of CASP8 protein
CTD PMID:16007152 PMID:19352495 PMID:24658017 PMID:29458164 PMID:31926150 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
increases activity
ISO
EXP
ACHE protein affects the susceptibility to [Staurosporine results in increased activity of CASP9 protein]; Staurosporine results in increased cleavage of and results in increased activity of CASP9 protein
Staurosporine results in increased cleavage of CASP9 protein
3-methyladenine promotes the reaction [Staurosporine results in increased cleavage of CASP9 protein]; Sirolimus inhibits the reaction [Staurosporine results in increased cleavage of CASP9 protein]
CTD PMID:16007152 PMID:16497721 PMID:19352495 PMID:20338155 PMID:26124276 More... NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 multiple interactions EXP Staurosporine inhibits the reaction [[CXCL8 protein binds to and results in increased activity of CXCR1 protein] which results in increased phosphorylation of and affects the localization of CCR5 protein] CTD PMID:12594210 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
JBrowse link
G Cd28 Cd28 molecule multiple interactions ISO Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD28 protein] CTD PMID:11465111 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CDKN1A protein] CTD PMID:15978937 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO Staurosporine inhibits the reaction [Tretinoin results in increased phosphorylation of CDKN1B protein] CTD PMID:16618747 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions
affects binding
ISO Staurosporine affects the reaction [KT 5720 promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]]; Staurosporine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]; Staurosporine promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]
Staurosporine binds to CHRM1 protein
CTD PMID:10860942 PMID:16439611 NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO Staurosporine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein] CTD PMID:10860942 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 affects binding EXP Staurosporine binds to CHRM3 protein CTD PMID:12435818 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Staurosporine inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] CTD PMID:18001288 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crh corticotropin releasing hormone multiple interactions EXP Staurosporine inhibits the reaction [CRH protein inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]] CTD PMID:2153673 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO CSF2 protein affects the susceptibility to [Nitroblue Tetrazolium co-treated with Staurosporine] CTD PMID:8471626 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Csn2 casein beta multiple interactions ISO Staurosporine inhibits the reaction [[INS1 protein co-treated with PRL protein] results in increased expression of CSN2 mRNA] CTD PMID:7648427 NCBI chr14:20,322,581...20,329,818
Ensembl chr14:20,322,581...20,329,817
JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 affects expression ISO Staurosporine affects the expression of CSNK2A2 mRNA CTD PMID:15721199 NCBI chr19:9,556,443...9,596,080
Ensembl chr19:9,556,260...9,596,080
JBrowse link
G Ctnnb1 catenin beta 1 increases phosphorylation EXP Staurosporine results in increased phosphorylation of CTNNB1 protein CTD PMID:19741129 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 multiple interactions EXP Staurosporine inhibits the reaction [[CXCL8 protein binds to and results in increased activity of CXCR1 protein] which results in increased phosphorylation of and affects the localization of CCR5 protein]; Staurosporine inhibits the reaction [[CXCL8 protein binds to and results in increased activity of CXCR1 protein] which results in increased phosphorylation of CXCR4 protein] CTD PMID:12594210 NCBI chr 9:75,768,124...75,771,122
Ensembl chr 9:75,766,770...75,771,084
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions EXP Staurosporine inhibits the reaction [[CXCL8 protein binds to and results in increased activity of CXCR1 protein] which results in increased phosphorylation of CXCR4 protein] CTD PMID:12594210 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of CYBB protein] CTD PMID:29183754 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO
EXP
Staurosporine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Staurosporine inhibits the reaction [benz(a)anthracene results in increased activity of CYP1A1 protein]; Staurosporine inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Staurosporine inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]
CTD PMID:1312672 PMID:7587946 PMID:9395520 PMID:10696073 PMID:15947024 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression
EXP Staurosporine inhibits the reaction [INS1 protein results in decreased expression of CYP2E1 mRNA]
Staurosporine results in increased expression of CYP2E1 mRNA
CTD PMID:11306697 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO Staurosporine inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA] CTD PMID:17965521 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Staurosporine results in increased expression of DDIT3 mRNA CTD PMID:32870474 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dedd death effector domain-containing affects expression ISO Staurosporine affects the expression of DEDD mRNA CTD PMID:15721199 NCBI chr13:83,755,874...83,769,982
Ensembl chr13:83,756,108...83,769,332
JBrowse link
G Dock1 dedicator of cyto-kinesis 1 multiple interactions ISO DOCK1 protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; DOCK1 protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein] CTD PMID:25586182 NCBI chr 1:189,467,143...189,983,777
Ensembl chr 1:189,467,143...189,983,768
JBrowse link
G Edf1 endothelial differentiation-related factor 1 multiple interactions
decreases expression
EXP Staurosporine inhibits the reaction [MBF1 protein results in increased secretion of NPPA protein]
Staurosporine results in decreased expression of MBF1 protein
CTD PMID:12729799 NCBI chr 3:8,377,058...8,381,363
Ensembl chr 3:8,366,613...8,381,363
JBrowse link
G Edn1 endothelin 1 decreases activity EXP Staurosporine results in decreased activity of EDN1 protein CTD PMID:15464066 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP Staurosporine inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]; Staurosporine inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein] CTD PMID:20561571 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G Egf epidermal growth factor multiple interactions ISO
EXP
Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]]]; Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein]]; Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK3 protein]]; Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]]
EGF protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; EGF protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]
CTD PMID:15542774 PMID:19406941 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein] CTD PMID:15177934 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 decreases activity ISO Staurosporine results in decreased activity of EIF2AK2 protein CTD PMID:12890478 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO Staurosporine results in increased phosphorylation of EIF2S1 protein CTD PMID:21090173 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Elmo1 engulfment and cell motility 1 multiple interactions ISO ELMO1 protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; ELMO1 protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein] CTD PMID:25586182 NCBI chr17:44,286,495...44,822,788
Ensembl chr17:44,286,485...44,822,788
JBrowse link
G Eomes eomesodermin multiple interactions ISO EOMES protein inhibits the reaction [Staurosporine results in increased cleavage of PARP1 protein]; EOMES protein inhibits the reaction [Staurosporine results in increased expression of CASP3 protein modified form]; EOMES protein inhibits the reaction [Staurosporine results in increased expression of CASP7 protein modified form] CTD PMID:27539959 NCBI chr 8:118,181,340...118,189,186
Ensembl chr 8:118,181,777...118,188,316
JBrowse link
G Epo erythropoietin decreases response to substance
multiple interactions
EXP EPO protein results in decreased susceptibility to Staurosporine
tin mesoporphyrin inhibits the reaction [EPO protein results in decreased susceptibility to Staurosporine]
CTD PMID:15816862 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease affects expression ISO Staurosporine affects the expression of ERCC5 mRNA CTD PMID:15721199 NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Staurosporine binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Staurosporine binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Staurosporine inhibits the reaction [Asbestos, Crocidolite results in increased expression of F3 mRNA] CTD PMID:15371228 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fermt2 FERM domain containing kindlin 2 affects expression ISO Staurosporine affects the expression of FERMT2 mRNA CTD PMID:15721199 NCBI chr15:18,682,927...18,751,959
Ensembl chr15:18,682,927...18,751,811
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP Staurosporine inhibits the reaction [Acetaldehyde results in increased expression of FN1 mRNA] CTD PMID:7945571 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Staurosporine inhibits the reaction [Acetaldehyde results in increased expression of FOS mRNA]; Staurosporine inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA] CTD PMID:7945571 PMID:9417049 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO Staurosporine promotes the reaction [MYC protein binds to GCLC promoter] CTD PMID:17628013 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO Staurosporine promotes the reaction [MYC protein binds to GCLM promoter] CTD PMID:17628013 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP Staurosporine inhibits the reaction [diphenylditelluride results in increased phosphorylation of GFAP protein] CTD PMID:21879721 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Grp gastrin releasing peptide multiple interactions ISO Staurosporine promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates] CTD PMID:18313772 NCBI chr18:59,388,679...59,402,061
Ensembl chr18:59,388,274...59,402,061
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions EXP Staurosporine inhibits the reaction [benz(a)anthracene results in increased activity of GSTA2 protein] CTD PMID:7587946 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO Staurosporine inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]; Staurosporine inhibits the reaction [Smoke analog results in increased expression of HMOX1 protein]; Staurosporine inhibits the reaction [VEGFA protein results in increased expression of HMOX1 protein]
Staurosporine results in increased expression of HMOX1 protein
SOD2 mutant form inhibits the reaction [Staurosporine results in increased expression of HMOX1 protein]; Staurosporine inhibits the reaction [hydroquinone results in increased expression of HMOX1 mRNA]; Staurosporine inhibits the reaction [hydroquinone results in increased expression of HMOX1 protein]
CTD PMID:12788823 PMID:18048804 PMID:23290930 PMID:24740755 PMID:28108387 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hr HR, lysine demethylase and nuclear receptor corepressor multiple interactions
affects response to substance
ISO
EXP
HR protein affects the reaction [Staurosporine results in increased activity of CASP3 protein]; TRP53 protein affects the reaction [HR protein affects the reaction [Staurosporine results in increased activity of CASP3 protein]]
HR protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; HR protein inhibits the reaction [Staurosporine results in increased expression of TP53 protein]
HR protein affects the susceptibility to Staurosporine
CTD PMID:20886113 NCBI chr15:45,626,835...45,646,313
Ensembl chr15:45,626,835...45,646,313
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
affects activity
EXP IGF1 protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; IGF1 protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]
Staurosporine affects the activity of IGF1 protein
CTD PMID:11548882 PMID:19406941 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il33 interleukin 33 multiple interactions
increases expression
ISO N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Staurosporine results in increased expression of IL33 protein] CTD PMID:25747661 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
JBrowse link
G Il4 interleukin 4 multiple interactions EXP Staurosporine inhibits the reaction [IL4 protein promotes the reaction [Ionomycin results in increased expression of TNFRSF4 protein]]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [IL4 protein results in increased expression of TNFRSF4 protein]] CTD PMID:9766631 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 decreases activity ISO Staurosporine results in decreased activity of IL5 protein CTD PMID:12562334 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Ins2 insulin 2 multiple interactions EXP Staurosporine inhibits the reaction [INS protein results in increased uptake of cobaltous chloride] CTD PMID:14622148 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Itgal integrin subunit alpha L multiple interactions ISO Staurosporine inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAL mRNA]; Staurosporine inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAL protein]; Staurosporine inhibits the reaction [TNF protein results in increased expression of ITGAL mRNA]; Staurosporine inhibits the reaction [TNF protein results in increased expression of ITGAL protein] CTD PMID:10198263 NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Staurosporine inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGAM protein] CTD PMID:18500357 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB2 protein] CTD PMID:16393473 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases phosphorylation
EXP Staurosporine inhibits the reaction [Acetaldehyde results in increased expression of JUN mRNA]
Staurosporine results in increased phosphorylation of JUN protein
CTD PMID:7945571 PMID:9751194 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kng2 kininogen 2 decreases activity EXP Staurosporine results in decreased activity of KNG1 CTD PMID:1334751 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971
JBrowse link
G Lmna lamin A/C increases cleavage ISO Staurosporine results in increased cleavage of LMNA protein CTD PMID:26124276 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein]]; Staurosporine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Staurosporine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Staurosporine promotes the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein]
Staurosporine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]
Staurosporine inhibits the reaction [diphenylditelluride results in increased phosphorylation of MAPK1 protein]
CTD PMID:11035063 PMID:15177934 PMID:15542774 PMID:16251475 PMID:17003101 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK3 protein]]; Staurosporine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Staurosporine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Staurosporine promotes the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK3 protein]
Staurosporine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein]
Staurosporine inhibits the reaction [diphenylditelluride results in increased phosphorylation of MAPK3 protein]
CTD PMID:11035063 PMID:15177934 PMID:15542774 PMID:16251475 PMID:17003101 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO
EXP
Staurosporine inhibits the reaction [oxophenylarsine results in increased phosphorylation of MAPT protein] CTD PMID:10737602 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mark1 microtubule affinity regulating kinase 1 multiple interactions ISO Staurosporine inhibits the reaction [oxophenylarsine results in increased activity of MARK1 protein] CTD PMID:10737602 NCBI chr13:96,450,189...96,555,304
Ensembl chr13:96,451,487...96,555,173
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases cleavage
decreases response to substance
ISO Staurosporine results in increased cleavage of MCL1 protein
MCL1 results in decreased susceptibility to Staurosporine
CTD PMID:15217956 PMID:16007152 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]]] CTD PMID:15542774 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Staurosporine inhibits the reaction [Homocysteine results in increased activity of MMP9 protein]; Staurosporine inhibits the reaction [Homocysteine results in increased expression of MMP9 protein] CTD PMID:16251475 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases response to substance
ISO MYC protein inhibits the reaction [Staurosporine results in increased abundance of Reactive Oxygen Species]; Staurosporine promotes the reaction [MYC protein binds to GCLC promoter]; Staurosporine promotes the reaction [MYC protein binds to GCLM promoter]
MYC protein results in decreased susceptibility to Staurosporine
CTD PMID:17628013 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nefl neurofilament light chain multiple interactions EXP Staurosporine inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFL protein] CTD PMID:21879721 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
JBrowse link
G Nefm neurofilament medium chain multiple interactions EXP Staurosporine inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFM protein] CTD PMID:21879721 NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases expression
ISO Staurosporine inhibits the reaction [Ethanol affects the localization of NFE2L2 protein]; Staurosporine inhibits the reaction [sulforaphane results in increased expression of NFE2L2 protein]
Staurosporine results in decreased expression of NFE2L2 protein modified form
CTD PMID:22530035 PMID:30703377 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Staurosporine inhibits the reaction [bisphenol A results in increased expression of NFKB1 protein] CTD PMID:20499049 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Ngf nerve growth factor multiple interactions ISO
EXP
Staurosporine inhibits the reaction [NGF results in increased susceptibility to Capsaicin]
Staurosporine inhibits the reaction [NGF protein results in increased uptake of Calcium]
CTD PMID:1374475 PMID:12815188 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Staurosporine inhibits the reaction [ginsenoside Rg3 results in increased expression of NOS2 protein] CTD PMID:14534150 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP Staurosporine inhibits the reaction [MBF1 protein results in increased secretion of NPPA protein] CTD PMID:12729799 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP
ISO
Staurosporine inhibits the reaction [benz(a)anthracene results in increased activity of NQO1 protein]
Staurosporine inhibits the reaction [Smoke analog results in increased expression of NQO1 protein]
CTD PMID:7587946 PMID:28108387 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Ntf3 neurotrophin 3 multiple interactions EXP Staurosporine inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Staurosporine inhibits the reaction [imetit results in increased expression of NTF3 protein]; Staurosporine inhibits the reaction [methylhistaprodifen results in increased expression of NTF3 protein]; Staurosporine inhibits the reaction [Neurotransmitter Agents results in increased expression of NTF3 protein] CTD PMID:19854260 PMID:21276809 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
JBrowse link
G Nts neurotensin multiple interactions
increases activity
ISO Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Staurosporine inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein]; Staurosporine promotes the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]; Tetradecanoylphorbol Acetate inhibits the reaction [Staurosporine results in increased activity of NTS protein] CTD PMID:15177934 PMID:18313772 NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases expression
increases cleavage
ISO
EXP
SOD2 mutant form inhibits the reaction [Staurosporine results in increased cleavage of PARP1 protein]; Staurosporine affects the reaction [sodium arsenite results in increased cleavage of PARP1 protein]
Staurosporine results in increased expression of PARP1 protein modified form
EOMES protein inhibits the reaction [Staurosporine results in increased cleavage of PARP1 protein]; Silybin inhibits the reaction [Staurosporine promotes the reaction [Acetaldehyde results in increased cleavage of PARP1 protein]]; Staurosporine promotes the reaction [Acetaldehyde results in increased cleavage of PARP1 protein]
CTD PMID:10704466 PMID:11035063 PMID:18451153 PMID:21447800 PMID:22639866 More... NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Staurosporine binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO [Hydrogen Peroxide co-treated with Staurosporine] results in increased acetylation of PPARGC1A protein; resveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in increased acetylation of PPARGC1A protein] CTD PMID:23293585 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta affects localization EXP Staurosporine affects the localization of PPP2R2B protein CTD PMID:18940801 NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha decreases response to substance
increases cleavage
ISO PPP3CA protein results in decreased susceptibility to Staurosporine
Staurosporine results in increased cleavage of PPP3CA protein
CTD PMID:10679475 PMID:10898953 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO Staurosporine inhibits the reaction [sodium arsenate results in increased expression of PRDX1 protein] CTD PMID:11796722 NCBI chr 5:130,147,276...130,162,850
Ensembl chr 5:130,147,204...130,162,856
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO
EXP
Staurosporine affects the localization of and affects the activity of PRKCA protein
[linsidomine co-treated with Staurosporine] results in decreased expression of PRKCA protein; Staurosporine inhibits the reaction [Heptachlor affects the localization of PRKCA protein]; Staurosporine inhibits the reaction [linsidomine results in increased phosphorylation of PRKCA protein]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]
CTD PMID:11994256 PMID:14678745 PMID:16225760 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO
EXP
Staurosporine inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]
Staurosporine inhibits the reaction [Heptachlor affects the localization of PRKCD protein]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCD protein]
CTD PMID:14678745 PMID:17171638 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Prl prolactin multiple interactions ISO Staurosporine inhibits the reaction [[INS1 protein co-treated with PRL protein] results in increased expression of CSN2 mRNA] CTD PMID:7648427 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Psen2 presenilin 2 multiple interactions ISO pifithrin inhibits the reaction [PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]]; PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]; Staurosporine promotes the reaction [PSEN2 protein mutant form results in increased expression of APP protein] CTD PMID:12556443 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174
JBrowse link
G Ptger3 prostaglandin E receptor 3 multiple interactions
decreases phosphorylation
EXP Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PTGER3 protein alternative form]
Staurosporine results in decreased phosphorylation of PTGER3 protein alternative form
CTD PMID:15937517 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434
JBrowse link
G Ptges3 prostaglandin E synthase 3 increases cleavage ISO Staurosporine results in increased cleavage of PTGES3 protein CTD PMID:26124276 NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Staurosporine inhibits the reaction [Nicotine results in increased expression of PTGS2] CTD PMID:17003101 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Staurosporine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]; Staurosporine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]
Staurosporine inhibits the reaction [bisphenol A results in increased expression of RELA protein]
CTD PMID:20499049 PMID:24021941 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ret ret proto-oncogene decreases expression EXP Staurosporine results in decreased expression of RET protein CTD PMID:17555550 NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176
JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B multiple interactions ISO [Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SDHB protein; resveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SDHB protein] CTD PMID:23293585 NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO [Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SIRT1 protein; resveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SIRT1 protein] CTD PMID:23293585 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions
decreases phosphorylation
ISO [Staurosporine results in decreased phosphorylation of SLC11A2 protein] which results in decreased uptake of Iron CTD PMID:27681840 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
JBrowse link
G Slc12a5 solute carrier family 12 member 5 increases activity
multiple interactions
ISO Staurosporine results in increased activity of SLC12A5 protein
Staurosporine inhibits the reaction [SLC12A5 protein results in increased import of Thallium]
CTD PMID:20086212 NCBI chr 3:153,696,522...153,735,801
Ensembl chr 3:153,696,517...153,735,765
JBrowse link
G Slc1a1 solute carrier family 1 member 1 multiple interactions
decreases activity
EXP Staurosporine inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]; Staurosporine inhibits the reaction [Progesterone results in increased activity of SLC1A1 protein]
Staurosporine results in decreased activity of SLC1A1 protein
CTD PMID:17382927 PMID:22511482 PMID:23262392 PMID:23602688 PMID:24355585 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402
JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions EXP Staurosporine inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC1A2 protein] CTD PMID:26988466 NCBI chr 3:89,005,129...89,126,498
Ensembl chr 3:89,005,129...89,126,498
JBrowse link
G Slc22a25 solute carrier family 22, member 25 multiple interactions ISO Staurosporine inhibits the reaction [Phorbol 12,13-Dibutyrate affects the localization of SLC22A9 protein]; Staurosporine inhibits the reaction [Phorbol 12,13-Dibutyrate results in decreased activity of SLC22A9 protein] CTD PMID:17341544 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085
JBrowse link
G Slc30a1 solute carrier family 30 member 1 multiple interactions ISO Staurosporine inhibits the reaction [Zinc Sulfate results in increased expression of SLC30A1 mRNA] CTD PMID:15142038 NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910
JBrowse link
G Slc5a6 solute carrier family 5 member 6 multiple interactions ISO Staurosporine inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] CTD PMID:15561972 NCBI chr 6:25,319,187...25,331,713
Ensembl chr 6:25,320,442...25,331,712
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
increases activity
ISO SNCA protein affects the reaction [Staurosporine results in increased activity of SLC6A3 protein] CTD PMID:19032594 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Slc6a4 solute carrier family 6 member 4 increases activity ISO staurosporine increases activity of SLC6A4 protein in placental choriocarcinoma cells RGD PMID:7615516 RGD:38500207 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link
G Snca synuclein alpha multiple interactions ISO [Staurosporine co-treated with Rotenone] promotes the reaction [SNCA protein binds to SNCA protein]; SNCA protein affects the reaction [Staurosporine results in increased activity of SLC6A3 protein] CTD PMID:19032594 PMID:19114014 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SOD2 protein; resveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SOD2 protein]; SOD2 mutant form inhibits the reaction [Staurosporine results in increased cleavage of PARP1 protein]; SOD2 mutant form inhibits the reaction [Staurosporine results in increased expression of HMOX1 protein] CTD PMID:23293585 PMID:24740755 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 multiple interactions
increases cleavage
ISO Staurosporine promotes the reaction [CASP3 protein results in increased cleavage of SPTAN1 protein]; VASP mutant form promotes the reaction [Staurosporine promotes the reaction [CASP3 protein results in increased cleavage of SPTAN1 protein]]
Staurosporine results in increased cleavage of SPTAN1 protein
CTD PMID:18182247 PMID:21683092 PMID:26124276 NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] CTD PMID:18448488 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein multiple interactions ISO Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of SYNCRIP protein] CTD PMID:19331829 NCBI chr 8:89,402,487...89,435,517
Ensembl chr 8:89,402,866...89,435,515
JBrowse link
G Tert telomerase reverse transcriptase decreases activity ISO Staurosporine results in decreased activity of TERT protein CTD PMID:9434777 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Staurosporine binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Staurosporine binds to and results in decreased activity of THRB protein CTD PMID:25752796 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions EXP Staurosporine inhibits the reaction [tert-Butylhydroperoxide affects the localization of TJP1 protein] CTD PMID:16716901 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Staurosporine inhibits the reaction [TNF protein results in increased expression of ITGAL mRNA]; Staurosporine inhibits the reaction [TNF protein results in increased expression of ITGAL protein] CTD PMID:10198263 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf4 TNF receptor superfamily member 4 multiple interactions
increases expression
EXP Staurosporine inhibits the reaction [IL4 protein promotes the reaction [Ionomycin results in increased expression of TNFRSF4 protein]]; Staurosporine inhibits the reaction [Ionomycin promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFRSF4 protein]]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [IL4 protein results in increased expression of TNFRSF4 protein]]; Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFRSF4 protein]; Staurosporine promotes the reaction [Mercuric Chloride results in increased expression of TNFRSF4 protein]
Staurosporine results in increased expression of TNFRSF4 protein
CTD PMID:9766631 NCBI chr 5:166,606,909...166,609,599
Ensembl chr 5:166,606,909...166,609,599
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO
EXP
Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]]]; Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]]; Staurosporine promotes the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]
TRP53 protein affects the reaction [HR protein affects the reaction [Staurosporine results in increased activity of CASP3 protein]]
HR protein inhibits the reaction [Staurosporine results in increased expression of TP53 protein]
CTD PMID:15542774 PMID:20886113 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions ISO VASP mutant form promotes the reaction [Staurosporine promotes the reaction [CASP3 protein results in increased cleavage of SPTAN1 protein]] CTD PMID:18182247 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061
JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions EXP 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [Staurosporine promotes the reaction [VDAC1 protein binds to VDAC1 protein]]; Staurosporine promotes the reaction [VDAC1 protein binds to VDAC1 protein] CTD PMID:20937774 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
JBrowse link
G Vdr vitamin D receptor increases cleavage ISO Staurosporine results in increased cleavage of VDR protein CTD PMID:18832097 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Staurosporine inhibits the reaction [VEGFA protein results in increased abundance of phosphatidylbutanol]; Staurosporine inhibits the reaction [VEGFA protein results in increased expression of HMOX1 protein] CTD PMID:12788823 PMID:14704231 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vim vimentin multiple interactions EXP Staurosporine inhibits the reaction [diphenylditelluride results in increased phosphorylation of VIM protein] CTD PMID:21879721 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Wt1 WT1 transcription factor increases expression ISO Staurosporine results in increased expression of WT1 protein CTD PMID:12914969 NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643
JBrowse link
midostaurin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO midostaurin results in decreased activity of ABCB1 protein CTD PMID:11836167 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Agt angiotensinogen multiple interactions EXP midostaurin inhibits the reaction [AGT protein results in increased abundance of Epoprostenol] CTD PMID:14613874 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions
decreases activity
ISO midostaurin inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Daunorubicin]; midostaurin inhibits the reaction [AKR1C3 protein results in increased metabolism of Daunorubicin]
midostaurin results in decreased activity of AKR1C3 protein
CTD PMID:33025066 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Casp3 caspase 3 multiple interactions ISO midostaurin promotes the reaction [Loratadine results in increased activity of CASP3 protein]; midostaurin promotes the reaction [Terfenadine results in increased activity of CASP3 protein] CTD PMID:20570632 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Egf epidermal growth factor multiple interactions ISO midostaurin inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]] CTD PMID:15542774 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 decreases activity ISO midostaurin results in decreased activity of FGFR3 protein CTD PMID:16091734 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases response to substance
decreases activity
ISO FLT3 protein results in decreased susceptibility to midostaurin
midostaurin results in decreased activity of FLT3 protein
CTD PMID:21980431 NCBI chr12:7,623,658...7,699,474
Ensembl chr12:7,623,930...7,699,474
JBrowse link
G Gypa glycophorin A decreases expression ISO midostaurin results in decreased expression of GYPA protein CTD PMID:19573588 NCBI chr19:27,450,311...27,465,940
Ensembl chr19:27,450,308...27,465,822
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO midostaurin inhibits the reaction [KIT protein polymorphism results in increased expression of HMOX1 protein] CTD PMID:17420286 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO midostaurin results in increased expression of and results in increased localization of ITGB3 protein CTD PMID:19573588 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions ISO midostaurin inhibits the reaction [KIT protein polymorphism results in increased expression of HMOX1 protein] CTD PMID:17420286 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO midostaurin affects the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein] CTD PMID:15542774 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO midostaurin affects the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK3 protein] CTD PMID:15542774 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mpl MPL proto-oncogene, thrombopoietin receptor increases expression ISO midostaurin results in increased expression of MPL protein CTD PMID:19573588 NCBI chr 5:131,973,897...131,987,472
Ensembl chr 5:131,973,895...131,986,797
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP midostaurin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] CTD PMID:14613874 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO midostaurin affects the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]; midostaurin inhibits the reaction [EGF protein inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]] CTD PMID:15542774 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19659
    role 19634
      biological role 19633
        biochemical role 19388
          apoptosis inducer 13431
            staurosporine 155
              3'-demethylstaurosporine 0
              7-oxo-3,8,9-trihydroxy staurosporine 0
              7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine 0
              linkable staurosporine analogue 0
              midostaurin 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    p-block element atom 19607
                      carbon group element atom 19550
                        carbon atom 19547
                          organic molecular entity 19588
                            organic group 18752
                              cyclic organic group 1887
                                organic heterobicyclic ring 1887
                                  indole skeleton 1887
                                    indole alkaloid 1888
                                      indolocarbazole alkaloid 155
                                        staurosporine 155
                                          3'-demethylstaurosporine 0
                                          7-oxo-3,8,9-trihydroxy staurosporine 0
                                          7-oxo-8,9-dihydroxy-4'-N-demethyl staurosporine 0
                                          linkable staurosporine analogue 0
                                          midostaurin 16
paths to the root