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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phosphonoacetic acid
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Accession:CHEBI:15732 term browser browse the term
Definition:A member of the class of phosphonic acids that is phosphonic acid in which the hydrogen attached to the phosphorous is replaced by a carboxymethyl group.
Synonyms:related_synonym: Formula=C2H5O5P;   Fosfonet;   InChI=1S/C2H5O5P/c3-2(4)1-8(5,6)7/h1H2,(H,3,4)(H2,5,6,7);   InChIKey=XUYJLQHKOGNDPB-UHFFFAOYSA-N;   Phosphonoacetate;   SMILES=OC(=O)CP(O)(O)=O
 alt_id: CHEBI:14824;   CHEBI:26071;   CHEBI:44900;   CHEBI:8156
 xref: CAS:4408-78-0;   DrugBank:DB02823;   HMDB:HMDB0004110;   KEGG:C05682;   PDBeChem:PAE;   PMID:16282466;   PMID:24335308;   PMID:24570323;   Reaxys:1764355
 cyclic_relationship: is_conjugate_acid_of CHEBI:57488


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pamidronate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated increases expression ISO pamidronate results in increased expression of ALPL protein CTD PMID:11683535 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G B2m beta-2 microglobulin decreases expression ISO pamidronate results in decreased expression of B2M protein CTD PMID:11683535 NCBI chr 3:114,087,287...114,093,311
Ensembl chr 3:114,087,287...114,093,309
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO pamidronate results in decreased expression of BCL2 protein CTD PMID:10780527 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression ISO pamidronate results in increased expression of BGLAP protein CTD PMID:11683535 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Bik BCL2-interacting killer increases response to substance ISO BIK protein results in increased susceptibility to pamidronate CTD PMID:16007125 NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO pamidronate results in increased cleavage of and results in increased activity of CASP3 protein
pamidronate results in increased cleavage of CASP3 protein
CTD PMID:15346059, PMID:16298452 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases cleavage ISO pamidronate results in increased cleavage of CASP9 protein CTD PMID:16298452 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO pamidronate results in decreased expression of COL1A1 mRNA; pamidronate results in decreased expression of COL1A1 protein CTD PMID:19597852 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Crp C-reactive protein decreases expression
increases expression
ISO pamidronate results in decreased expression of CRP protein
pamidronate results in increased expression of CRP protein
CTD PMID:9351880, PMID:11683535 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Fdps farnesyl diphosphate synthase decreases activity ISO
EXP
pamidronate results in decreased activity of FDPS protein CTD PMID:11160603, PMID:18325729 NCBI chr 2:188,403,595...188,413,219
Ensembl chr 2:188,392,858...188,413,219
JBrowse link
G Fgf23 fibroblast growth factor 23 decreases expression ISO pamidronate results in decreased expression of FGF23 protein CTD PMID:15838626 NCBI chr 4:159,622,404...159,630,082
Ensembl chr 4:159,622,404...159,630,082
JBrowse link
G Il18 interleukin 18 multiple interactions ISO [Pamidronate results in increased susceptibility to Acetylmuramyl-Alanyl-Isoglutamine] which results in increased secretion of IL18 protein CTD PMID:21282739 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta increases secretion
multiple interactions
ISO Pamidronate results in increased secretion of IL1B protein
[Pamidronate co-treated with Acetylmuramyl-Alanyl-Isoglutamine] results in increased secretion of IL1B protein; [Pamidronate co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein; geraniol inhibits the reaction [[Pamidronate co-treated with Acetylmuramyl-Alanyl-Isoglutamine] results in increased secretion of IL1B protein]; geraniol inhibits the reaction [[Pamidronate co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; Pamidronate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1B protein]
CTD PMID:21282739 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases expression
increases expression
ISO pamidronate results in decreased expression of IL6 protein
pamidronate results in increased expression of IL6 protein
CTD PMID:9351880, PMID:11683535 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases expression ISO pamidronate results in decreased expression of MAPK1 protein modified form CTD PMID:16298452 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO pamidronate results in increased cleavage of PARP1 protein
[pamidronate co-treated with ultra-high molecular weight polyethylene] results in increased cleavage of PARP1 protein
CTD PMID:10780527, PMID:12507583, PMID:15346059 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pon1 paraoxonase 1 decreases activity
multiple interactions
EXP pamidronate results in decreased activity of PON1 protein
[pamidronate results in decreased activity of PON1 protein] which results in decreased metabolism of homocysteine thiolactone; [pamidronate results in decreased activity of PON1 protein] which results in decreased metabolism of Paraoxon; [pamidronate results in decreased activity of PON1 protein] which results in decreased metabolism of phenyl acetate
CTD PMID:27387541 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family decreases prenylation ISO pamidronate results in decreased prenylation of RAP1A protein CTD PMID:11595616 NCBI chr 2:208,193,950...208,215,186
Ensembl chr 2:208,193,954...208,215,187
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO pamidronate results in decreased expression of RHOA protein modified form CTD PMID:16298452 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 decreases expression ISO pamidronate results in decreased expression of ROCK1 protein CTD PMID:16298452 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO pamidronate results in increased expression of TNF protein
pamidronate inhibits the reaction [ultra-high molecular weight polyethylene results in increased secretion of TNF protein]
CTD PMID:9351880, PMID:12507583 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions
increases expression
ISO pamidronate inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]; pamidronate inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]
pamidronate results in increased expression of TNFRSF11B mRNA; pamidronate results in increased expression of TNFRSF11B protein
CTD PMID:11855844 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        antimicrobial agent 17312
          antiviral agent 10246
            phosphonoacetic acid 22
              FR 900098 0
              Formylphosphonate 0
              Fosfomycin tromethamine 0
              ethylphosphonic acid 0
              pamidronate 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        monocarboxylic acid 17407
                                          acetic acid 10697
                                            phosphonoacetic acid 22
                                              FR 900098 0
                                              Formylphosphonate 0
                                              Fosfomycin tromethamine 0
                                              ethylphosphonic acid 0
                                              pamidronate 22
paths to the root

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