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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phosphonoacetic acid
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Accession:CHEBI:15732 term browser browse the term
Definition:A member of the class of phosphonic acids that is phosphonic acid in which the hydrogen attached to the phosphorous is replaced by a carboxymethyl group.
Synonyms:related_synonym: Formula=C2H5O5P;   Fosfonet;   InChI=1S/C2H5O5P/c3-2(4)1-8(5,6)7/h1H2,(H,3,4)(H2,5,6,7);   InChIKey=XUYJLQHKOGNDPB-UHFFFAOYSA-N;   Phosphonoacetate;   SMILES=OC(=O)CP(O)(O)=O
 alt_id: CHEBI:14824;   CHEBI:26071;   CHEBI:44900;   CHEBI:8156
 xref: CAS:4408-78-0;   DrugBank:DB02823;   HMDB:HMDB0004110;   KEGG:C05682;   PDBeChem:PAE;   PMID:16282466;   PMID:24335308;   PMID:24570323;   Reaxys:1764355
 cyclic_relationship: is_conjugate_acid_of CHEBI:57488


show annotations for term's descendants           Sort by:
pamidronate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated increases expression ISO pamidronate results in increased expression of ALPL protein CTD PMID:11683535 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G B2m beta-2 microglobulin decreases expression ISO pamidronate results in decreased expression of B2M protein CTD PMID:11683535 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO pamidronate results in decreased expression of BCL2 protein CTD PMID:10780527 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression ISO pamidronate results in increased expression of BGLAP protein CTD PMID:11683535 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Bik BCL2-interacting killer increases response to substance ISO BIK protein results in increased susceptibility to pamidronate CTD PMID:16007125 NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage		 ISO pamidronate results in increased cleavage of and results in increased activity of CASP3 protein
pamidronate results in increased cleavage of CASP3 protein		 CTD PMID:15346059 PMID:16298452 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO pamidronate results in increased cleavage of CASP9 protein CTD PMID:16298452 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO pamidronate results in decreased expression of COL1A1 mRNA; pamidronate results in decreased expression of COL1A1 protein CTD PMID:19597852 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Crp C-reactive protein decreases expression
increases expression		 ISO pamidronate results in decreased expression of CRP protein
pamidronate results in increased expression of CRP protein		 CTD PMID:9351880 PMID:11683535 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO [Arsenic Trioxide co-treated with Pamidronate] promotes the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Pamidronate promotes the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:32337366 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [Arsenic Trioxide co-treated with Pamidronate] promotes the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Pamidronate promotes the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:32337366 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Fdps farnesyl diphosphate synthase decreases activity ISO
EXP		 pamidronate results in decreased activity of FDPS protein CTD PMID:11160603 PMID:18325729 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776 		JBrowse link
G Fgf23 fibroblast growth factor 23 decreases expression ISO pamidronate results in decreased expression of FGF23 protein CTD PMID:15838626 NCBI chr 4:159,914,267...159,923,821
Ensembl chr 4:159,914,272...159,923,821 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO [Pamidronate results in increased susceptibility to Acetylmuramyl-Alanyl-Isoglutamine] which results in increased secretion of IL18 protein CTD PMID:21282739 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta increases secretion
multiple interactions		 ISO Pamidronate results in increased secretion of IL1B protein
[Pamidronate co-treated with Acetylmuramyl-Alanyl-Isoglutamine] results in increased secretion of IL1B protein; [Pamidronate co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein; geraniol inhibits the reaction [[Pamidronate co-treated with Acetylmuramyl-Alanyl-Isoglutamine] results in increased secretion of IL1B protein]; geraniol inhibits the reaction [[Pamidronate co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; Pamidronate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1B protein]		 CTD PMID:21282739 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 decreases expression
increases expression		 ISO pamidronate results in decreased expression of IL6 protein
pamidronate results in increased expression of IL6 protein		 CTD PMID:9351880 PMID:11683535 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases expression ISO pamidronate results in decreased expression of MAPK1 protein modified form CTD PMID:16298452 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions		 ISO pamidronate results in increased cleavage of PARP1 protein
[pamidronate co-treated with ultra-high molecular weight polyethylene] results in increased cleavage of PARP1 protein		 CTD PMID:10780527 PMID:12507583 PMID:15346059 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pon1 paraoxonase 1 decreases activity
multiple interactions		 EXP pamidronate results in decreased activity of PON1 protein
[pamidronate results in decreased activity of PON1 protein] which results in decreased metabolism of homocysteine thiolactone; [pamidronate results in decreased activity of PON1 protein] which results in decreased metabolism of Paraoxon; [pamidronate results in decreased activity of PON1 protein] which results in decreased metabolism of phenyl acetate		 CTD PMID:27387541 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions ISO Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Pamidronate results in decreased expression of and results in decreased activity of PTPN1 protein]]; Acetylcysteine inhibits the reaction [Pamidronate promotes the reaction [Arsenic Trioxide results in decreased expression of and results in decreased activity of PTPN1 protein]]; Acetylcysteine inhibits the reaction [Pamidronate results in decreased expression of and results in decreased activity of PTPN1 protein]; Arsenic Trioxide promotes the reaction [Pamidronate results in decreased expression of and results in decreased activity of PTPN1 protein]; Pamidronate promotes the reaction [Arsenic Trioxide results in decreased expression of and results in decreased activity of PTPN1 protein]; Pamidronate results in decreased expression of and results in decreased activity of PTPN1 protein CTD PMID:32337366 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO pamidronate increases expression of RAC1 mRNA in cholangiocarcinoma cells, pamidronate decreases expression of RAC1 protein in cholangiocarcinoma cells RGD PMID:31611937 RGD:153345545 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family decreases prenylation ISO pamidronate results in decreased prenylation of RAP1A protein CTD PMID:11595616 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501 		JBrowse link
G Rhoa ras homolog family member A decreases expression ISO pamidronate results in decreased expression of RHOA protein modified form CTD PMID:16298452 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 decreases expression ISO pamidronate results in decreased expression of ROCK1 protein CTD PMID:16298452 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO pamidronate results in increased expression of TNF protein
pamidronate inhibits the reaction [ultra-high molecular weight polyethylene results in increased secretion of TNF protein]		 CTD PMID:9351880 PMID:12507583 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions
increases expression		 ISO pamidronate inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]; pamidronate inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]
pamidronate results in increased expression of TNFRSF11B mRNA; pamidronate results in increased expression of TNFRSF11B protein		 CTD PMID:11855844 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      biological role 19805
        antimicrobial agent 18125
          antiviral agent 11069
            phosphonoacetic acid 26
              (2-acetamido-1-hydroxyethyl)phosphonic acid 0
              (cyano(hydroxy)methyl)phosphonic acid 0
              1-Aminoethylphosphonic Acid 0
              2-Acetamidoethylphosphonate 0
              FR 900098 0
              Formylphosphonate 0
              Fosfazinomycin B 0
              Fosfomycin sodium 0
              Fosfomycin tromethamine 0
              Fosfonochlorin 0
              Fosmidomycin sodium salt 0
              Fr-33289 0
              MPH 0
              Tetradecyl phosphonic acid 0
              [Nitrilotris(methylene)]trisphosphonic acid 0
              ethylphosphonic acid 0
              pamidronate 26
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            heteroorganic entity 19477
                              organochalcogen compound 19240
                                organooxygen compound 19155
                                  carbon oxoacid 18613
                                    carboxylic acid 18610
                                      monocarboxylic acid 17966
                                        acetic acid 11053
                                          phosphonoacetic acid 26
                                            (2-acetamido-1-hydroxyethyl)phosphonic acid 0
                                            (cyano(hydroxy)methyl)phosphonic acid 0
                                            1-Aminoethylphosphonic Acid 0
                                            2-Acetamidoethylphosphonate 0
                                            FR 900098 0
                                            Formylphosphonate 0
                                            Fosfazinomycin B 0
                                            Fosfomycin sodium 0
                                            Fosfomycin tromethamine 0
                                            Fosfonochlorin 0
                                            Fosmidomycin sodium salt 0
                                            Fr-33289 0
                                            MPH 0
                                            Tetradecyl phosphonic acid 0
                                            [Nitrilotris(methylene)]trisphosphonic acid 0
                                            ethylphosphonic acid 0
                                            pamidronate 26
paths to the root