phosphonoacetic acid - Ontology Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

{{ watchLinkText }}

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	phosphonoacetic acid	go back to main search page
Accession:	CHEBI:15732	browse the term
Definition:	A member of the class of phosphonic acids that is phosphonic acid in which the hydrogen attached to the phosphorous is replaced by a carboxymethyl group.
Synonyms:	related_synonym:	Formula=C2H5O5P; Fosfonet; InChI=1S/C2H5O5P/c3-2(4)1-8(5,6)7/h1H2,(H,3,4)(H2,5,6,7); InChIKey=XUYJLQHKOGNDPB-UHFFFAOYSA-N; Phosphonoacetate; SMILES=OC(=O)CP(O)(O)=O
	alt_id:	CHEBI:14824; CHEBI:26071; CHEBI:44900; CHEBI:8156
	xref:	CAS:4408-78-0; DrugBank:DB02823; HMDB:HMDB0004110; KEGG:C05682; PDBeChem:PAE; PMID:16282466; PMID:24335308; PMID:24570323; Reaxys:1764355
	cyclic_relationship:	is_conjugate_acid_of CHEBI:57488

show annotations for term's descendants Sort by:
Rat (35) Mouse (35) Human (36) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (35)

pamidronate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenomedullin

increases expression

Pamidronate results in increased expression of ADM mRNA

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

alkaline phosphatase, biomineralization associated

increases expression

pamidronate results in increased expression of ALPL protein

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

beta-2 microglobulin

decreases expression

pamidronate results in decreased expression of B2M protein

NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766

G

BCL2, apoptosis regulator

decreases expression

pamidronate results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bone gamma-carboxyglutamate protein

increases expression

pamidronate results in increased expression of BGLAP protein

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

BCL2-interacting killer

increases response to substance

BIK protein results in increased susceptibility to pamidronate

NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296

G

caspase 3

multiple interactions
increases cleavage

pamidronate results in increased cleavage of and results in increased activity of CASP3 protein
pamidronate results in increased cleavage of CASP3 protein

PMID:15346059 PMID:16298452

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

increases cleavage

pamidronate results in increased cleavage of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

collagen type I alpha 1 chain

decreases expression

pamidronate results in decreased expression of COL1A1 mRNA; pamidronate results in decreased expression of COL1A1 protein

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

C-reactive protein

decreases expression
increases expression

pamidronate results in decreased expression of CRP protein
pamidronate results in increased expression of CRP protein

PMID:9351880 PMID:11683535

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

C-X-C motif chemokine receptor 4

increases expression

Pamidronate results in increased expression of CXCR4 mRNA

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

dual specificity phosphatase 1

increases expression

Pamidronate results in increased expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

G

epidermal growth factor

multiple interactions

[Arsenic Trioxide co-treated with Pamidronate] promotes the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Pamidronate promotes the reaction [EGF protein results in increased phosphorylation of EGFR protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

multiple interactions

[Arsenic Trioxide co-treated with Pamidronate] promotes the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Pamidronate promotes the reaction [EGF protein results in increased phosphorylation of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

farnesyl diphosphate synthase

decreases activity

pamidronate results in decreased activity of FDPS protein

PMID:11160603 PMID:18325729

NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776

G

fibroblast growth factor 23

decreases expression

pamidronate results in decreased expression of FGF23 protein

NCBI chr 4:159,914,267...159,923,821
Ensembl chr 4:159,914,272...159,923,821

G

interleukin 18

multiple interactions

[Pamidronate results in increased susceptibility to Acetylmuramyl-Alanyl-Isoglutamine] which results in increased secretion of IL18 protein

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 beta

increases secretion
multiple interactions

Pamidronate results in increased secretion of IL1B protein
[Pamidronate co-treated with Acetylmuramyl-Alanyl-Isoglutamine] results in increased secretion of IL1B protein; [Pamidronate co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein; geraniol inhibits the reaction [[Pamidronate co-treated with Acetylmuramyl-Alanyl-Isoglutamine] results in increased secretion of IL1B protein]; geraniol inhibits the reaction [[Pamidronate co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; Pamidronate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

decreases expression
increases expression

pamidronate results in decreased expression of IL6 protein
pamidronate results in increased expression of IL6 protein

PMID:9351880 PMID:11683535

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

kelch domain containing 2

decreases expression

Pamidronate results in decreased expression of KLHDC2 mRNA

NCBI chr 6:87,777,183...87,791,609
Ensembl chr 6:87,777,183...87,804,187

G

lactate dehydrogenase A

increases expression

Pamidronate results in increased expression of LDHA mRNA

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

MAF bZIP transcription factor F

increases expression

Pamidronate results in increased expression of MAFF mRNA

NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851

G

mitogen activated protein kinase 1

decreases expression

pamidronate results in decreased expression of MAPK1 protein modified form

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

methylsterol monooxygenase 1

increases expression

Pamidronate results in increased expression of MSMO1 mRNA

NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016

G

poly (ADP-ribose) polymerase 1

increases cleavage
multiple interactions

pamidronate results in increased cleavage of PARP1 protein
[pamidronate co-treated with ultra-high molecular weight polyethylene] results in increased cleavage of PARP1 protein

PMID:10780527 PMID:12507583 PMID:15346059

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

paraoxonase 1

decreases activity
multiple interactions

pamidronate results in decreased activity of PON1 protein
[pamidronate results in decreased activity of PON1 protein] which results in decreased metabolism of homocysteine thiolactone; [pamidronate results in decreased activity of PON1 protein] which results in decreased metabolism of Paraoxon; [pamidronate results in decreased activity of PON1 protein] which results in decreased metabolism of phenyl acetate

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

G

protein phosphatase 1, regulatory subunit 15A

increases expression

Pamidronate results in increased expression of PPP1R15A mRNA

NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171

G

protein tyrosine phosphatase, non-receptor type 1

multiple interactions

Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Pamidronate results in decreased expression of and results in decreased activity of PTPN1 protein]]; Acetylcysteine inhibits the reaction [Pamidronate promotes the reaction [Arsenic Trioxide results in decreased expression of and results in decreased activity of PTPN1 protein]]; Acetylcysteine inhibits the reaction [Pamidronate results in decreased expression of and results in decreased activity of PTPN1 protein]; Arsenic Trioxide promotes the reaction [Pamidronate results in decreased expression of and results in decreased activity of PTPN1 protein]; Pamidronate promotes the reaction [Arsenic Trioxide results in decreased expression of and results in decreased activity of PTPN1 protein]; Pamidronate results in decreased expression of and results in decreased activity of PTPN1 protein

NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504

G

Rac family small GTPase 1

multiple interactions

pamidronate increases expression of RAC1 mRNA in cholangiocarcinoma cells, pamidronate decreases expression of RAC1 protein in cholangiocarcinoma cells

RGD

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

RAP1A, member of RAS oncogene family

decreases prenylation

pamidronate results in decreased prenylation of RAP1A protein

NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501

G

ras homolog family member A

decreases expression

pamidronate results in decreased expression of RHOA protein modified form

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

Rho-associated coiled-coil containing protein kinase 1

decreases expression

pamidronate results in decreased expression of ROCK1 protein

NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571

G

SERTA domain containing 1

increases expression

Pamidronate results in increased expression of SERTAD1 mRNA

NCBI chr 1:82,775,692...82,778,961
Ensembl chr 1:82,775,252...82,779,091

G

tumor necrosis factor

increases expression
multiple interactions

pamidronate results in increased expression of TNF protein
pamidronate inhibits the reaction [ultra-high molecular weight polyethylene results in increased secretion of TNF protein]

PMID:9351880 PMID:12507583

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 11B

multiple interactions
increases expression

pamidronate inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]; pamidronate inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]
pamidronate results in increased expression of TNFRSF11B mRNA; pamidronate results in increased expression of TNFRSF11B protein

NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19932
role	19904
biological role	19902
antimicrobial agent	18269
antiviral agent	11338
phosphonoacetic acid	35
(2-acetamido-1-hydroxyethyl)phosphonic acid	0
(cyano(hydroxy)methyl)phosphonic acid	0
1-Aminoethylphosphonic Acid	0
2-Acetamidoethylphosphonate	0
FR 900098	0
Formylphosphonate	0
Fosfazinomycin B	0
Fosfomycin sodium	0
Fosfomycin tromethamine	0
Fosfonochlorin	0
Fosmidomycin sodium salt	0
Fr-33289	0
MPH	0
Tetradecyl phosphonic acid	0
[Nitrilotris(methylene)]trisphosphonic acid	0
ethylphosphonic acid	0
pamidronate	35
Path 2
Term	Annotations
CHEBI ontology	19932
subatomic particle	19930
composite particle	19930
hadron	19930
baryon	19930
nucleon	19930
atomic nucleus	19930
atom	19930
main group element atom	19876
p-block element atom	19876
carbon group element atom	19816
carbon atom	19812
organic molecular entity	19812
heteroorganic entity	19559
organochalcogen compound	19317
organooxygen compound	19231
carbon oxoacid	18687
carboxylic acid	18684
monocarboxylic acid	18025
acetic acid	11089
phosphonoacetic acid	35
(2-acetamido-1-hydroxyethyl)phosphonic acid	0
(cyano(hydroxy)methyl)phosphonic acid	0
1-Aminoethylphosphonic Acid	0
2-Acetamidoethylphosphonate	0
FR 900098	0
Formylphosphonate	0
Fosfazinomycin B	0
Fosfomycin sodium	0
Fosfomycin tromethamine	0
Fosfonochlorin	0
Fosmidomycin sodium salt	0
Fr-33289	0
MPH	0
Tetradecyl phosphonic acid	0
[Nitrilotris(methylene)]trisphosphonic acid	0
ethylphosphonic acid	0
pamidronate	35

paths to the root