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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phosphonoacetic acid
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Accession:CHEBI:15732 term browser browse the term
Definition:A member of the class of phosphonic acids that is phosphonic acid in which the hydrogen attached to the phosphorous is replaced by a carboxymethyl group.
Synonyms:related_synonym: Formula=C2H5O5P;   Fosfonet;   InChI=1S/C2H5O5P/c3-2(4)1-8(5,6)7/h1H2,(H,3,4)(H2,5,6,7);   InChIKey=XUYJLQHKOGNDPB-UHFFFAOYSA-N;   Phosphonoacetate;   SMILES=OC(=O)CP(O)(O)=O
 alt_id: CHEBI:14824;   CHEBI:26071;   CHEBI:44900;   CHEBI:8156
 xref: CAS:4408-78-0;   DrugBank:DB02823;   HMDB:HMDB0004110;   KEGG:C05682;   PDBeChem:PAE;   PMID:16282466;   PMID:24335308;   PMID:24570323;   Reaxys:1764355
 cyclic_relationship: is_conjugate_acid_of CHEBI:57488


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pamidronate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated increases expression ISO pamidronate results in increased expression of ALPL protein CTD PMID:11683535 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G B2m beta-2 microglobulin decreases expression ISO pamidronate results in decreased expression of B2M protein CTD PMID:11683535 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO pamidronate results in decreased expression of BCL2 protein CTD PMID:10780527 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression ISO pamidronate results in increased expression of BGLAP protein CTD PMID:11683535 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Bik BCL2-interacting killer increases response to substance ISO BIK protein results in increased susceptibility to pamidronate CTD PMID:16007125 NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO pamidronate results in increased cleavage of and results in increased activity of CASP3 protein
pamidronate results in increased cleavage of CASP3 protein
CTD PMID:15346059 PMID:16298452 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases cleavage ISO pamidronate results in increased cleavage of CASP9 protein CTD PMID:16298452 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO pamidronate results in decreased expression of COL1A1 mRNA; pamidronate results in decreased expression of COL1A1 protein CTD PMID:19597852 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Crp C-reactive protein decreases expression
increases expression
ISO pamidronate results in decreased expression of CRP protein
pamidronate results in increased expression of CRP protein
CTD PMID:9351880 PMID:11683535 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Fdps farnesyl diphosphate synthase decreases activity ISO
EXP
pamidronate results in decreased activity of FDPS protein CTD PMID:11160603 PMID:18325729 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
JBrowse link
G Fgf23 fibroblast growth factor 23 decreases expression ISO pamidronate results in decreased expression of FGF23 protein CTD PMID:15838626 NCBI chr 4:159,914,393...159,922,073
Ensembl chr 4:159,914,272...159,923,821
JBrowse link
G Il18 interleukin 18 multiple interactions ISO [Pamidronate results in increased susceptibility to Acetylmuramyl-Alanyl-Isoglutamine] which results in increased secretion of IL18 protein CTD PMID:21282739 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta increases secretion
multiple interactions
ISO Pamidronate results in increased secretion of IL1B protein
[Pamidronate co-treated with Acetylmuramyl-Alanyl-Isoglutamine] results in increased secretion of IL1B protein; [Pamidronate co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein; geraniol inhibits the reaction [[Pamidronate co-treated with Acetylmuramyl-Alanyl-Isoglutamine] results in increased secretion of IL1B protein]; geraniol inhibits the reaction [[Pamidronate co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; Pamidronate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1B protein]
CTD PMID:21282739 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 decreases expression
increases expression
ISO pamidronate results in decreased expression of IL6 protein
pamidronate results in increased expression of IL6 protein
CTD PMID:9351880 PMID:11683535 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases expression ISO pamidronate results in decreased expression of MAPK1 protein modified form CTD PMID:16298452 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO pamidronate results in increased cleavage of PARP1 protein
[pamidronate co-treated with ultra-high molecular weight polyethylene] results in increased cleavage of PARP1 protein
CTD PMID:10780527 PMID:12507583 PMID:15346059 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pon1 paraoxonase 1 decreases activity
multiple interactions
EXP pamidronate results in decreased activity of PON1 protein
[pamidronate results in decreased activity of PON1 protein] which results in decreased metabolism of homocysteine thiolactone; [pamidronate results in decreased activity of PON1 protein] which results in decreased metabolism of Paraoxon; [pamidronate results in decreased activity of PON1 protein] which results in decreased metabolism of phenyl acetate
CTD PMID:27387541 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family decreases prenylation ISO pamidronate results in decreased prenylation of RAP1A protein CTD PMID:11595616 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO pamidronate results in decreased expression of RHOA protein modified form CTD PMID:16298452 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 decreases expression ISO pamidronate results in decreased expression of ROCK1 protein CTD PMID:16298452 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO pamidronate results in increased expression of TNF protein
pamidronate inhibits the reaction [ultra-high molecular weight polyethylene results in increased secretion of TNF protein]
CTD PMID:9351880 PMID:12507583 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions
increases expression
ISO pamidronate inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]; pamidronate inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]
pamidronate results in increased expression of TNFRSF11B mRNA; pamidronate results in increased expression of TNFRSF11B protein
CTD PMID:11855844 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        antimicrobial agent 17400
          antiviral agent 10293
            phosphonoacetic acid 22
              FR 900098 0
              Formylphosphonate 0
              Fosfomycin tromethamine 0
              [Nitrilotris(methylene)]trisphosphonic acid 0
              ethylphosphonic acid 0
              pamidronate 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        monocarboxylic acid 17632
                                          acetic acid 10854
                                            phosphonoacetic acid 22
                                              FR 900098 0
                                              Formylphosphonate 0
                                              Fosfomycin tromethamine 0
                                              [Nitrilotris(methylene)]trisphosphonic acid 0
                                              ethylphosphonic acid 0
                                              pamidronate 22
paths to the root