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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:trimethylenediamine
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Accession:CHEBI:15725 term browser browse the term
Definition:An alkane-alpha,omega-diamine comprising a propane skeleton with amino substituents at positions 1 and 3.
Synonyms:related_synonym: 1,3-Diaminopropane;   1,3-Propanediamine;   1,3-diamino-n-propane;   1,3-propylenediamine;   1,3-trimethylenediamine;   3-aminopropylamine;   Formula=C3H10N2;   InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2;   InChIKey=XFNJVJPLKCPIBV-UHFFFAOYSA-N;   Propane-1,3-diamine;   SMILES=NCCCN;   alpha,omega-propanediamine;   tn
 alt_id: CHEBI:11166;   CHEBI:14901;   CHEBI:26285;   CHEBI:39528;   CHEBI:519
 xref: Beilstein:605277;   CAS:109-76-2;   Gmelin:1298;   HMDB:HMDB0000002;   KEGG:C00986;   KNApSAcK:C00007404
 xref_mesh: MESH:C009475
 xref: MetaCyc:CPD-313;   PDBeChem:13D;   PMID:1035932;   PMID:10930630;   PMID:1238529;   PMID:17668437;   PMID:4798530;   PMID:6042782;   PMID:739391;   PMID:987217;   Reaxys:605277;   Wikipedia:1\,3-Diaminopropane
 cyclic_relationship: is_conjugate_base_of CHEBI:57484


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trimethylenediamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO [Copper binds to Isatin binds to trimethylenediamine] which results in increased cleavage of CASP3 protein CTD PMID:17327230 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO [Copper binds to Isatin binds to trimethylenediamine] which results in increased cleavage of CASP9 protein CTD PMID:17327230 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of CDKN1A protein; Tretinoin inhibits the reaction [[Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of CDKN1A protein] CTD PMID:17327230 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [Copper binds to Isatin binds to trimethylenediamine] which affects the localization of CYCS protein CTD PMID:17327230 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [trimethylenediamine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]; [trimethylenediamine binds to TEMPO] inhibits the reaction [MPO protein results in increased degradation of Hydrogen Peroxide]; [trimethylenediamine binds to TEMPO] inhibits the reaction [MPO protein results in increased oxidation of Nitric Oxide]; Heparin inhibits the reaction [[trimethylenediamine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]] CTD PMID:34085520 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO SOD1 protein results in decreased susceptibility to [Copper binds to Isatin binds to trimethylenediamine] CTD PMID:17327230 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of TP53 protein; Tretinoin inhibits the reaction [[Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of TP53 protein] CTD PMID:17327230 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19751
    role 19724
      application 19557
        reagent 17825
          trimethylenediamine 7
            N-(3-aminopropyl)-N-hydroxyacetamide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19751
    subatomic particle 19749
      composite particle 19749
        hadron 19749
          baryon 19749
            nucleon 19749
              atomic nucleus 19749
                atom 19749
                  main group element atom 19698
                    main group molecular entity 19698
                      s-block molecular entity 19554
                        hydrogen molecular entity 19546
                          hydrides 19022
                            inorganic hydride 17950
                              pnictogen hydride 17936
                                nitrogen hydride 17835
                                  azane 17621
                                    ammonia 17620
                                      organic amino compound 17620
                                        polyamine 8326
                                          diamine 8254
                                            primary diamine 5688
                                              alkane-alpha,omega-diamine 3768
                                                trimethylenediamine 7
                                                  N-(3-aminopropyl)-N-hydroxyacetamide 0
paths to the root