Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:trimethylenediamine
go back to main search page
Accession:CHEBI:15725 term browser browse the term
Definition:An alkane-alpha,omega-diamine comprising a propane skeleton with amino substituents at positions 1 and 3.
Synonyms:related_synonym: 1,3-Diaminopropane;   1,3-Propanediamine;   1,3-propylenediamine;   Formula=C3H10N2;   InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2;   InChIKey=XFNJVJPLKCPIBV-UHFFFAOYSA-N;   Propane-1,3-diamine;   SMILES=NCCCN;   tn
 alt_id: CHEBI:11166;   CHEBI:14901;   CHEBI:26285;   CHEBI:39528;   CHEBI:519
 xref: Beilstein:605277;   CAS:109-76-2;   Gmelin:1298;   HMDB:HMDB0000002;   KEGG:C00986;   KNApSAcK:C00007404
 xref_mesh: MESH:C009475
 xref: MetaCyc:CPD-313;   PDBeChem:13D;   PMID:1035932;   PMID:10930630;   PMID:1238529;   PMID:17668437;   PMID:4798530;   PMID:6042782;   PMID:739391;   PMID:987217;   Reaxys:605277;   Wikipedia:1\,3-Diaminopropane
 cyclic_relationship: is_conjugate_base_of CHEBI:57484



show annotations for term's descendants           Sort by:
 
trimethylenediamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO [Copper binds to Isatin binds to trimethylenediamine] which results in increased cleavage of CASP3 protein CTD PMID:17327230 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [Copper binds to Isatin binds to trimethylenediamine] which results in increased cleavage of CASP9 protein CTD PMID:17327230 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of CDKN1A protein; Tretinoin inhibits the reaction [[Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of CDKN1A protein] CTD PMID:17327230 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [Copper binds to Isatin binds to trimethylenediamine] which affects the localization of CYCS protein CTD PMID:17327230 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [trimethylenediamine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]; [trimethylenediamine binds to TEMPO] inhibits the reaction [MPO protein results in increased degradation of Hydrogen Peroxide]; [trimethylenediamine binds to TEMPO] inhibits the reaction [MPO protein results in increased oxidation of Nitric Oxide]; Heparin inhibits the reaction [[trimethylenediamine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]] CTD PMID:34085520 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO SOD1 protein results in decreased susceptibility to [Copper binds to Isatin binds to trimethylenediamine] CTD PMID:17327230 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of TP53 protein; Tretinoin inhibits the reaction [[Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of TP53 protein] CTD PMID:17327230 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19763
      application 19477
        reagent 17485
          trimethylenediamine 7
            N-(3-aminopropyl)-N-hydroxyacetamide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19710
                    main group molecular entity 19710
                      s-block molecular entity 19492
                        hydrogen molecular entity 19484
                          hydrides 18850
                            inorganic hydride 17700
                              pnictogen hydride 17681
                                nitrogen hydride 17552
                                  azane 17289
                                    ammonia 17288
                                      organic amino compound 17288
                                        polyamine 8275
                                          diamine 8203
                                            primary diamine 5676
                                              alkane-alpha,omega-diamine 3763
                                                trimethylenediamine 7
                                                  N-(3-aminopropyl)-N-hydroxyacetamide 0
paths to the root