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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:trimethylamine N-oxide
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Accession:CHEBI:15724 term browser browse the term
Definition:A tertiary amine oxide resulting from the oxidation of the amino group of trimethylamine.
Synonyms:related_synonym: (CH3)3NO;   Formula=C3H9NO;   InChI=1S/C3H9NO/c1-4(2,3)5/h1-3H3;   InChIKey=UYPYRKYUKCHHIB-UHFFFAOYSA-N;   Me3N(O);   N(CH3)3O;   N,N-dimethylmethanamine oxide;   SMILES=C[N+](C)([O-])C;   TMAO;   Trimethylaminoxid;   trimethylamine oxide;   trimethyloxamine
 alt_id: CHEBI:15262;   CHEBI:15263;   CHEBI:27126;   CHEBI:9733
 xref: Beilstein:1734787;   CAS:1184-78-7;   Gmelin:1839;   HMDB:HMDB0000925;   KEGG:C01104
 xref_mesh: MESH:C005855
 xref: MetaCyc:TRIMENTHLAMINE-N-O;   PDBeChem:TMO;   PMID:12683801;   PMID:1453985;   PMID:17697669;   PMID:19425246;   PMID:22770225;   PMID:3170512;   PMID:3674879;   Reaxys:1734787;   Wikipedia:Trimethylamine_oxide
 cyclic_relationship: is_conjugate_base_of CHEBI:166856


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trimethylamine N-oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 protein] CTD PMID:25568320 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Casp3 caspase 3 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased cleavage of CASP3 protein] CTD PMID:25568320 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of DDIT3 protein] CTD PMID:25568320 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Mbp myelin basic protein multiple interactions ISO trimethyloxamine promotes the reaction [MBP protein binds to MBP protein]; trimethyloxamine promotes the reaction [MBP protein mutant form binds to MBP protein mutant form] CTD PMID:12372316 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 multiple interactions
increases reduction
ISO [MTARC1 protein results in increased reduction of trimethyloxamine] which results in increased chemical synthesis of trimethylamine; NAD affects the reaction [MTARC1 protein results in increased reduction of trimethyloxamine] CTD PMID:29856598 NCBI chr13:102,693,679...102,724,120
Ensembl chr13:102,698,546...102,721,218
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects abundance ISO SLCO1A4 protein affects the abundance of trimethyloxamine CTD PMID:21561886 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Vamp2 vesicle-associated membrane protein 2 multiple interactions EXP trimethyloxamine promotes the reaction [rimabotulinumtoxinB results in increased cleavage of VAMP2 protein modified form] CTD PMID:27032463 NCBI chr10:55,675,171...55,679,405
Ensembl chr10:55,675,575...55,679,450
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      biological role 19711
        osmolyte 2048
          trimethylamine N-oxide 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    main group molecular entity 19653
                      s-block molecular entity 19418
                        hydrogen molecular entity 19411
                          hydrides 18751
                            inorganic hydride 17451
                              pnictogen hydride 17426
                                nitrogen hydride 17271
                                  azane 17007
                                    ammonia 17006
                                      organic amino compound 17005
                                        amine 7799
                                          alkylamines 185
                                            methylamines 17
                                              trimethylamine 9
                                                trimethylamine N-oxide 7
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