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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phloxine O
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Accession:CHEBI:156496 term browser browse the term
Definition:A xanthene dye that is fluorescein in which the hydrogens at positions 2',4',5' and 7' are replaced by bromo groups, and the hydrogens at positions 4,5,6 and 7 are replaced by chloro groups. It is a red synthetic pigment which is widely used in colored cosmetics (e.g. lipsticks and blushers).
Synonyms:exact_synonym: 2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-3',6'-dihydroxy-3H-spiro[[2]benzofuran-1,9'-xanthen]-3-one
 related_synonym: 2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one;   2',4',5',7'-tetrabromo-4,5,6,7-tetrachlorofluorescein;   C.I. 45410A;   C.I. solvent red 48;   CI 45410:1;   CI Solvent Red 48;   D & C red No. 27;   D and C red No. 27;   Formula=C20H4Br4Cl4O5;   InChI=1S/C20H4Br4Cl4O5/c21-5-1-3-17(9(23)15(5)29)32-18-4(2-6(22)16(30)10(18)24)20(3)8-7(19(31)33-20)11(25)13(27)14(28)12(8)26/h1-2,29-30H;   InChIKey=ZYIBVBKZZZDFOY-UHFFFAOYSA-N;   Japan red 218;   SMILES=OC1=C(Br)C2=C(C=C1Br)C1(OC(=O)C3=C1C(Cl)=C(Cl)C(Cl)=C3Cl)C1=CC(Br)=C(O)C(Br)=C1O2;   acid phloxine PB;   phloxine BBN supra;   red No. 218;   solvent red 48
 xref: CAS:13473-26-2;   PMID:12924789;   PMID:16494889;   PMID:22475185;   PMID:24646430;   PMID:29310423

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phloxine O term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tslp thymic stromal lymphopoietin multiple interactions ISO Phloxine O inhibits the reaction [calcipotriol increases expression of Tslp mRNA and protein in skin of external ear and phorbol 12-myristate 13-acetate increases expression of Tslp protein in keratinocytes] RGD PMID:29310423 RGD:38549374 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    role 20024
      application 19760
        dye 1372
          xanthene dye 80
            phloxine O 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19971
                    p-block element atom 19971
                      carbon group element atom 19894
                        carbon atom 19887
                          organic molecular entity 19887
                            organic group 18965
                              organic divalent group 18951
                                organodiyl group 18951
                                  carbonyl group 18903
                                    carbonyl compound 18903
                                      carboxylic acid 18601
                                        aromatic carboxylic acid 11816
                                          benzoic acids 11791
                                            fluorescein (acid form) 67
                                              fluorescein (lactone form) 66
                                                phloxine O 1
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