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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phloxine O
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Accession:CHEBI:156496 term browser browse the term
Definition:A xanthene dye that is fluorescein in which the hydrogens at positions 2',4',5' and 7' are replaced by bromo groups, and the hydrogens at positions 4,5,6 and 7 are replaced by chloro groups. It is a red synthetic pigment which is widely used in colored cosmetics (e.g. lipsticks and blushers).
Synonyms:exact_synonym: 2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-3',6'-dihydroxy-3H-spiro[[2]benzofuran-1,9'-xanthen]-3-one
 related_synonym: 2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one;   2',4',5',7'-tetrabromo-4,5,6,7-tetrachlorofluorescein;   C.I. 45410A;   C.I. solvent red 48;   CI 45410:1;   CI Solvent Red 48;   D & C red No. 27;   D and C red No. 27;   Formula=C20H4Br4Cl4O5;   InChI=1S/C20H4Br4Cl4O5/c21-5-1-3-17(9(23)15(5)29)32-18-4(2-6(22)16(30)10(18)24)20(3)8-7(19(31)33-20)11(25)13(27)14(28)12(8)26/h1-2,29-30H;   InChIKey=ZYIBVBKZZZDFOY-UHFFFAOYSA-N;   Japan red 218;   SMILES=OC1=C(Br)C2=C(C=C1Br)C1(OC(=O)C3=C1C(Cl)=C(Cl)C(Cl)=C3Cl)C1=CC(Br)=C(O)C(Br)=C1O2;   acid phloxine PB;   phloxine BBN supra;   red No. 218;   solvent red 48
 xref: CAS:13473-26-2;   PMID:12924789;   PMID:16494889;   PMID:22475185;   PMID:24646430;   PMID:29310423

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phloxine O term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tslp thymic stromal lymphopoietin multiple interactions ISO Phloxine O inhibits the reaction [calcipotriol increases expression of Tslp mRNA and protein in skin of external ear and phorbol 12-myristate 13-acetate increases expression of Tslp protein in keratinocytes] RGD PMID:29310423 RGD:38549374 NCBI chr18:25,613,601...25,618,066
Ensembl chr18:25,613,831...25,617,361
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      application 19401
        dye 1309
          xanthene dye 79
            phloxine O 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic group 18593
                              organic divalent group 18584
                                organodiyl group 18584
                                  carbonyl group 18499
                                    carbonyl compound 18499
                                      carboxylic ester 15500
                                        lactone 9716
                                          gamma-lactone 6498
                                            fluorescein 67
                                              phloxine O 1
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