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ONTOLOGY REPORT - ANNOTATIONS


Term:leukotriene B4
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Accession:CHEBI:15647 term browser browse the term
Definition:A leukotriene composed of (6Z,8E,10E,14Z)-icosatetraenoic acid having (5S)- and (12R)-hydroxy substituents.
Synonyms:related_synonym: (5S,12R,6Z,8E,10E,14Z)-5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid;   (5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyeicosa-6,8,10,14-tetraenoic acid;   (6z,8e,10e,14z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid;   (S-(R*,S*-(E,Z,E,Z)))-5,12-Dihydroxy-6,8,10,14-eicosatetraenoic acid;   5(S),12(R)-dihydroxy-6(Z),8(E),10(E),14(Z)-eicosatetraenoic acid;   5(S),12(R)-dihydroxy-6(Z),8(E),10(E),14(Z)-icosatetraenoic acid;   5,12-Dihete;   5,12-Hete;   5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid;   Formula=C20H32O4;   InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1;   InChIKey=VNYSSYRCGWBHLG-AMOLWHMGSA-N;   LTB4;   SMILES=CCCCC\\C=C/C[C@@H](O)\\C=C\\C=C\\C=C/[C@@H](O)CCCC(O)=O
 alt_id: CHEBI:10933;   CHEBI:25024;   CHEBI:6421
 xref: CAS:71160-24-2 "ChemIDplus";   CAS:71160-24-2 "KEGG COMPOUND";   HMDB:HMDB0001085;   KEGG:C02165;   LIPID_MAPS_instance:LMFA03020001 "LIPID MAPS"
 xref_mesh: MESH:D007975
 xref: PMID:20400503 "Europe PMC";   PMID:20529300 "Europe PMC";   PMID:6271967 "Europe PMC";   Reaxys:4235309 "Reaxys";   Wikipedia:Leukotriene_B4
 cyclic_relationship: is_conjugate_acid_of CHEBI:57461


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leukotriene B4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acta2 actin, alpha 2, smooth muscle, aorta JBrowse link 19 34,240,336 34,255,585 RGD:6480464
G Ahr aryl-hydrocarbon receptor JBrowse link 12 35,497,979 35,534,989 RGD:6480464
G Akt1 thymoma viral proto-oncogene 1 JBrowse link 12 112,653,821 112,674,884 RGD:6480464
G Alox5 arachidonate 5-lipoxygenase JBrowse link 6 116,410,071 116,461,178 RGD:6480464
G Alox5ap arachidonate 5-lipoxygenase activating protein JBrowse link 5 149,265,004 149,288,153 RGD:6480464
G Bax BCL2-associated X protein JBrowse link 7 45,461,695 45,466,903 RGD:6480464
G Ccl12 chemokine (C-C motif) ligand 12 JBrowse link 11 82,101,845 82,103,399 RGD:6480464
G Ccl2 chemokine (C-C motif) ligand 2 JBrowse link 11 82,035,577 82,037,452 RGD:6480464
G Ccl5 chemokine (C-C motif) ligand 5 JBrowse link 11 83,525,778 83,530,518 RGD:6480464
G Col1a1 collagen, type I, alpha 1 JBrowse link 11 94,936,224 94,953,042 RGD:6480464
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) JBrowse link 11 54,247,270 54,249,899 RGD:6480464
G Cxcl15 chemokine (C-X-C motif) ligand 15 JBrowse link 5 90,794,534 90,803,067 RGD:6480464
G Cxcl3 chemokine (C-X-C motif) ligand 3 JBrowse link 5 90,786,101 90,788,093 RGD:6480464
G Cysltr1 cysteinyl leukotriene receptor 1 JBrowse link X 106,576,509 106,603,679 RGD:6480464
G Fgf2 fibroblast growth factor 2 JBrowse link 3 37,348,477 37,410,106 RGD:6480464
G Hc hemolytic complement JBrowse link 2 34,983,329 35,068,506 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 8 75,093,618 75,100,593 RGD:6480464
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 JBrowse link 8 105,518,746 105,523,988 RGD:6480464
G Ifng interferon gamma JBrowse link 10 118,441,046 118,445,894 RGD:6480464
G Il10 interleukin 10 JBrowse link 1 131,019,845 131,024,970 RGD:6480464
G Il12b interleukin 12b JBrowse link 11 44,400,063 44,414,677 RGD:6480464
G Il13 interleukin 13 JBrowse link 11 53,631,323 53,634,702 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 2 129,364,569 129,371,164 RGD:6480464
G Il4 interleukin 4 JBrowse link 11 53,612,460 53,618,665 RGD:6480464
G Itgam integrin alpha M JBrowse link 7 128,062,640 128,118,491 RGD:6480464
G Itgb2 integrin beta 2 JBrowse link 10 77,530,329 77,565,708 RGD:6480464
G Lta4h leukotriene A4 hydrolase JBrowse link 10 93,453,396 93,484,896 RGD:6480464
G Ltb4r1 leukotriene B4 receptor 1 JBrowse link 14 55,764,160 55,768,494 RGD:6480464
G Ltb4r2 leukotriene B4 receptor 2 JBrowse link 14 55,757,922 55,764,066 RGD:6480464
G Mapk1 mitogen-activated protein kinase 1 JBrowse link 16 16,983,382 17,047,453 RGD:6480464
G Mapk3 mitogen-activated protein kinase 3 JBrowse link 7 126,759,626 126,765,816 RGD:6480464
G Mcl1 myeloid cell leukemia sequence 1 JBrowse link 3 95,656,944 95,663,179 RGD:6480464
G Mgst1 microsomal glutathione S-transferase 1 JBrowse link 6 138,140,527 138,156,755 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 2 164,940,326 164,955,850 RGD:6480464
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric JBrowse link 7 141,788,958 141,819,227 RGD:6480464
G Nos2 nitric oxide synthase 2, inducible JBrowse link 11 78,920,787 78,960,226 RGD:6480464
G Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) JBrowse link 1 149,829,618 149,961,290 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 15 85,734,910 85,806,851 RGD:6480464
G Sell selectin, lymphocyte JBrowse link 1 164,061,987 164,082,930 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 7 25,687,002 25,705,077 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20742
    chemical entity 20741
      atom 20735
        nonmetal atom 20626
          carbon atom 20367
            organic molecular entity 20367
              lipid 17574
                fatty acid 16343
                  long-chain fatty acid 1657
                    leukotriene B4 40
                      10,11-dihydro-12-oxoleukotriene B4 0
                      10,11-dihydro-20,20,20-trihydroxyleukotriene B4 0
                      10,11-dihydro-20,20-dihydroxyleukotriene B4 0
                      12,20-dioxoleukotriene B4 0
                      12-dehydro-leukotriene B4 0
                      12-oxo-20-hydroxyleukotriene B4 0
                      18-hydroxy-18-oxo-dinorleukotriene B4 0
                      18-hydroxyleukotriene B4 0
                      19-hydroxyleukotriene B4 0
                      20,20,20-trihydroxyleukotriene B4 0
                      20,20-dihydroxyleukotriene B4 0
                      20-hydroxy-20-oxoleukotriene B4 + 0
                      20-hydroxy-leukotriene B4 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20742
    subatomic particle 20735
      composite particle 20735
        hadron 20735
          baryon 20735
            nucleon 20735
              atomic nucleus 20735
                atom 20735
                  main group element atom 20655
                    p-block element atom 20655
                      carbon group element atom 20391
                        carbon atom 20367
                          organic molecular entity 20367
                            organic group 19036
                              organic divalent group 19026
                                organodiyl group 19026
                                  carbonyl group 18997
                                    carbonyl compound 18997
                                      carboxylic acid 18668
                                        monocarboxylic acid 17887
                                          fatty acid 16343
                                            unsaturated fatty acid 899
                                              polyunsaturated fatty acid 653
                                                fatty acid 20:4 315
                                                  icosatetraenoic acid 315
                                                    icosa-6,8,10,14-tetraenoic acid 40
                                                      leukotriene B4 40
                                                        10,11-dihydro-12-oxoleukotriene B4 0
                                                        10,11-dihydro-20,20,20-trihydroxyleukotriene B4 0
                                                        10,11-dihydro-20,20-dihydroxyleukotriene B4 0
                                                        12,20-dioxoleukotriene B4 0
                                                        12-dehydro-leukotriene B4 0
                                                        12-oxo-20-hydroxyleukotriene B4 0
                                                        18-hydroxy-18-oxo-dinorleukotriene B4 0
                                                        18-hydroxyleukotriene B4 0
                                                        19-hydroxyleukotriene B4 0
                                                        20,20,20-trihydroxyleukotriene B4 0
                                                        20,20-dihydroxyleukotriene B4 0
                                                        20-hydroxy-20-oxoleukotriene B4 + 0
                                                        20-hydroxy-leukotriene B4 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.