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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:holomycin
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Accession:CHEBI:156451 term browser browse the term
Definition:A dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 5 and 6 have been replaced by oxo and acetamido groups, respectively. It is an inhibitor of DNA-dependent RNA polymerase, and exhibits antibacterial and antitumour properties.
Synonyms:related_synonym: 6-(acetylamino)-1,2-dithiolo[4,3-b]pyrrol-5(4H)-one;   6-acetamido-1,2-dithiolo[4,3-b]pyrrol-5(4H)-one;   Formula=C7H6N2O2S2;   InChI=1S/C7H6N2O2S2/c1-3(10)8-5-6-4(2-12-13-6)9-7(5)11/h2H,1H3,(H,8,10)(H,9,11);   InChIKey=HBUNPJGMNVQSBX-UHFFFAOYSA-N;   N-(4,5-dihydro-5-oxo-1,2-dithiolo-[4,3-b]pyrrol-6-yl)acetamide;   N-(5-oxo-4H-dithiolo[4,3-b]pyrrol-6-yl)acetamide;   N-demethylthiolutin;   N-{5-oxo-4H,5H-[1,2]dithiolo[4,3-b]pyrrol-6-yl}acetamide;   SMILES=CC(=O)NC1=C2SSC=C2NC1=O
 xref: CAS:488-04-0;   MetaCyc:CPD-17940;   PMID:11158751;   PMID:12426344;   PMID:16890414;   PMID:17606690;   PMID:21041678;   PMID:21339958;   PMID:21342467;   PMID:21504228;   PMID:22344669;   PMID:23097183;   PMID:23147422;   PMID:23572522;   PMID:24141227;   PMID:24323287;   PMID:27018252;   PMID:28209778;   PMID:28627048;   PMID:28740758;   PMID:30194098;   PMID:32642829;   PMID:468729;   PMID:863793;   PMID:894386;   Reaxys:188430


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  CHEBI ontology 0
    role 0
      biological role 0
        antimicrobial agent 0
          antibacterial agent 0
            holomycin 0
              thiolutin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 0
    subatomic particle 0
      composite particle 0
        hadron 0
          baryon 0
            nucleon 0
              atomic nucleus 0
                atom 0
                  main group element atom 0
                    p-block element atom 0
                      carbon group element atom 0
                        carbon atom 0
                          organic molecular entity 0
                            heteroorganic entity 0
                              organochalcogen compound 0
                                organooxygen compound 0
                                  carbon oxoacid 0
                                    carboxylic acid 0
                                      carboacyl group 0
                                        univalent carboacyl group 0
                                          carbamoyl group 0
                                            carboxamide 0
                                              lactam 0
                                                gamma-lactam 0
                                                  dithiolopyrrolone antibiotic 0
                                                    holomycin 0
                                                      thiolutin 0
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