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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:10-formyltetrahydrofolic acid
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Accession:CHEBI:15637 term browser browse the term
Definition:A form of tetrahydrofolate that acts as a donor of formyl groups in anabolism. In these reactions 10-formyltetrahydrofolic acid is used as a substrate in formyltransferase reactions, which is important in purine biosynthesis.
Synonyms:exact_synonym: N-(4-{[(2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl](formyl)amino}benzoyl)-L-glutamic acid
 related_synonym: 10-FTHF;   10-Formyl-THF;   10-Formyltetrahydrofolate;   10-HCO-H4folic acid;   10-formyl-(6RS)-tetrahydrofolic acid;   10-formyl-5,6,7,8-tetrahydrofolic acid;   10-formyltetrahydropteroylglutamic acid;   Formula=C20H21N7O7;   InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/t11?,13-/m0/s1;   InChIKey=AUFGTPPARQZWDO-YUZLPWPTSA-N;   N(10)-formyl-5,6,7,8-tetrahydrofolic acid;   N(10)-formyl-THF;   N(10)-formyltetrahydrofolic acid;   N-(10-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid;   SMILES=[H]C(=O)N(CC1CNC2=C(N1)C(=O)NC(N)=N2)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
 alt_id: CHEBI:11304;   CHEBI:19108;   CHEBI:19109;   CHEBI:698
 xref: Beilstein:101559;   CAS:2800-34-2;   FooDB:FDB022345;   HMDB:HMDB0000972;   KEGG:C00234;   KNApSAcK:C00007251
 xref_mesh: MESH:C010161
 xref: PMID:1095054;   PMID:13336106;   PMID:13672973;   PMID:9833324
 cyclic_relationship: is_conjugate_acid_of CHEBI:57454


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10-formyltetrahydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 increases metabolic processing ISO ALDH1L2 protein results in increased metabolism of 10-formyltetrahydropteroylglutamic acid CTD PMID:21238436 NCBI chr10:83,320,386...83,370,008
Ensembl chr10:83,323,314...83,370,004 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      biological role 22178
        biochemical role 21449
          metabolite 21397
            prokaryotic metabolite 19213
              bacterial metabolite 19213
                Escherichia coli metabolite 19109
                  10-formyltetrahydrofolic acid 1
                    (6R)-10-formyltetrahydrofolic acid 0
                    (6S)-10-formyltetrahydrofolic acid 0
                    10-formyltetrahydrofolyl polyglutamate macromolecule + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    main group molecular entity 22120
                      s-block molecular entity 21717
                        hydrogen molecular entity 21634
                          hydrides 20777
                            inorganic hydride 18692
                              pnictogen hydride 18672
                                nitrogen hydride 18540
                                  azane 18447
                                    ammonia 18446
                                      organic amino compound 18446
                                        amino acid 16431
                                          alpha-amino acid 14225
                                            L-alpha-amino acid 13321
                                              glutamine family amino acid 10792
                                                L-glutamic acid 10725
                                                  L-glutamic acid derivative 9845
                                                    folic acids 9845
                                                      tetrahydrofolic acid 68
                                                        formyltetrahydrofolic acid 60
                                                          10-formyltetrahydrofolic acid 1
                                                            (6R)-10-formyltetrahydrofolic acid 0
                                                            (6S)-10-formyltetrahydrofolic acid 0
                                                            10-formyltetrahydrofolyl polyglutamate macromolecule + 0
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