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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:10-formyltetrahydrofolic acid
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Accession:CHEBI:15637 term browser browse the term
Definition:A form of tetrahydrofolate that acts as a donor of formyl groups in anabolism. In these reactions 10-formyltetrahydrofolic acid is used as a substrate in formyltransferase reactions, which is important in purine biosynthesis.
Synonyms:exact_synonym: N-[4-(N-{[(6S)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}formamido)benzoyl]-L-glutamic acid
 related_synonym: (6S)-10-HCO-H4folate;   10-FTHF;   10-Formyl-THF;   10-Formyltetrahydrofolate;   10-formyltetrahydropteroylglutamic acid;   Formula=C20H23N7O7;   InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/t11-,13+/m1/s1;   InChIKey=AUFGTPPARQZWDO-YPMHNXCESA-N;   N-(10-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid;   SMILES=[H]C(=O)N(C[C@H]1CNc2nc(N)[nH]c(=O)c2N1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
 alt_id: CHEBI:11304;   CHEBI:19108;   CHEBI:19109;   CHEBI:698
 xref: Beilstein:101559;   CAS:2800-34-2;   KEGG:C00234;   KNApSAcK:C00007251
 xref_mesh: MESH:C010161
 cyclic_relationship: is_conjugate_acid_of CHEBI:57454

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10-formyltetrahydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 increases metabolic processing ISO ALDH1L2 protein results in increased metabolism of 10-formyltetrahydropteroylglutamic acid CTD PMID:21238436 NCBI chr 7:26,375,866...26,425,838
Ensembl chr 7:26,375,866...26,425,108
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            prokaryotic metabolite 18356
              bacterial metabolite 18356
                Escherichia coli metabolite 18260
                  10-formyltetrahydrofolic acid 1
                    10-formyltetrahydrofolyl polyglutamate macromolecule + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        amino acid 14072
                                          alpha-amino acid 11539
                                            L-alpha-amino acid 11374
                                              glutamine family amino acid 10243
                                                L-glutamic acid 10190
                                                  L-glutamic acid derivative 9354
                                                    folic acids 9354
                                                      tetrahydrofolic acid 66
                                                        formyltetrahydrofolic acid 58
                                                          10-formyltetrahydrofolic acid 1
                                                            10-formyltetrahydrofolyl polyglutamate macromolecule + 0
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