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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:10-formyltetrahydrofolic acid
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Accession:CHEBI:15637 term browser browse the term
Definition:A form of tetrahydrofolate that acts as a donor of formyl groups in anabolism. In these reactions 10-formyltetrahydrofolic acid is used as a substrate in formyltransferase reactions, which is important in purine biosynthesis.
Synonyms:exact_synonym: N-[4-(N-{[(6S)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}formamido)benzoyl]-L-glutamic acid
 related_synonym: (6S)-10-HCO-H4folate;   10-FTHF;   10-Formyl-THF;   10-Formyltetrahydrofolate;   10-formyltetrahydropteroylglutamic acid;   Formula=C20H23N7O7;   InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/t11-,13+/m1/s1;   InChIKey=AUFGTPPARQZWDO-YPMHNXCESA-N;   N-(10-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid;   SMILES=[H]C(=O)N(C[C@H]1CNc2nc(N)[nH]c(=O)c2N1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
 alt_id: CHEBI:11304;   CHEBI:19108;   CHEBI:19109;   CHEBI:698
 xref: Beilstein:101559;   CAS:2800-34-2;   KEGG:C00234;   KNApSAcK:C00007251
 xref_mesh: MESH:C010161
 cyclic_relationship: is_conjugate_acid_of CHEBI:57454

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10-formyltetrahydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 increases metabolic processing ISO ALDH1L2 protein results in increased metabolism of 10-formyltetrahydropteroylglutamic acid CTD PMID:21238436 NCBI chr 7:20,254,196...20,305,793
Ensembl chr 7:20,254,233...20,305,776
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Term paths to the root
Path 1
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  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          metabolite 19364
            prokaryotic metabolite 18426
              bacterial metabolite 18426
                Escherichia coli metabolite 18313
                  10-formyltetrahydrofolic acid 1
                    10-formyltetrahydrofolyl polyglutamate macromolecule + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        amino acid 14879
                                          alpha-amino acid 12854
                                            L-alpha-amino acid 11559
                                              glutamine family amino acid 10263
                                                L-glutamic acid 10208
                                                  L-glutamic acid derivative 9369
                                                    folic acids 9369
                                                      tetrahydrofolic acid 66
                                                        formyltetrahydrofolic acid 58
                                                          10-formyltetrahydrofolic acid 1
                                                            10-formyltetrahydrofolyl polyglutamate macromolecule + 0
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