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Term:10-formyltetrahydrofolic acid
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Accession:CHEBI:15637 term browser browse the term
Definition:A form of tetrahydrofolate that acts as a donor of formyl groups in anabolism. In these reactions 10-formyltetrahydrofolic acid is used as a substrate in formyltransferase reactions, which is important in purine biosynthesis.
Synonyms:exact_synonym: N-[4-(N-{[(6S)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}formamido)benzoyl]-L-glutamic acid
 related_synonym: (6S)-10-HCO-H4folate;   10-FTHF;   10-Formyl-THF;   10-Formyltetrahydrofolate;   10-formyltetrahydropteroylglutamic acid;   Formula=C20H23N7O7;   InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/t11-,13+/m1/s1;   InChIKey=AUFGTPPARQZWDO-YPMHNXCESA-N;   N-(10-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid;   SMILES=[H]C(=O)N(C[C@H]1CNc2nc(N)[nH]c(=O)c2N1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
 alt_id: CHEBI:11304;   CHEBI:19108;   CHEBI:19109;   CHEBI:698
 xref: Beilstein:101559 "Beilstein";   CAS:2800-34-2 "ChemIDplus";   CAS:2800-34-2 "KEGG COMPOUND";   KEGG:C00234;   KNApSAcK:C00007251
 xref_mesh: MESH:C010161
 cyclic_relationship: is_conjugate_acid_of CHEBI:57454

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10-formyltetrahydrofolic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 JBrowse link 7 26,375,866 26,425,838 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19679
    role 19623
      biological role 19621
        biochemical role 19147
          metabolite 19115
            prokaryotic metabolite 18243
              bacterial metabolite 18243
                Escherichia coli metabolite 18136
                  10-formyltetrahydrofolic acid 1
                    10-formyltetrahydrofolyl polyglutamate macromolecule + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19679
    subatomic particle 19675
      composite particle 19675
        hadron 19675
          baryon 19675
            nucleon 19675
              atomic nucleus 19675
                atom 19675
                  main group element atom 19555
                    p-block element atom 19555
                      carbon group element atom 19438
                        carbon atom 19430
                          organic molecular entity 19430
                            organic group 18351
                              organic divalent group 18340
                                organodiyl group 18340
                                  carbonyl group 18225
                                    carbonyl compound 18225
                                      carboxylic acid 17930
                                        amino acid 12314
                                          alpha-amino acid 7427
                                            L-alpha-amino acid 7084
                                              glutamine family amino acid 5344
                                                L-glutamic acid 5246
                                                  L-glutamic acid derivative 3707
                                                    folic acids 3703
                                                      tetrahydrofolic acid 63
                                                        formyltetrahydrofolic acid 55
                                                          10-formyltetrahydrofolic acid 1
                                                            10-formyltetrahydrofolyl polyglutamate macromolecule + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.