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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:10-formyltetrahydrofolic acid
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Accession:CHEBI:15637 term browser browse the term
Definition:A form of tetrahydrofolate that acts as a donor of formyl groups in anabolism. In these reactions 10-formyltetrahydrofolic acid is used as a substrate in formyltransferase reactions, which is important in purine biosynthesis.
Synonyms:related_synonym: 10-FTHF;   10-Formyl-THF;   10-Formyltetrahydrofolate;   10-HCO-H4folic acid;   10-formyl-(6RS)-tetrahydrofolic acid;   10-formyl-5,6,7,8-tetrahydrofolic acid;   10-formyltetrahydropteroylglutamic acid;   N(10)-formyl-5,6,7,8-tetrahydrofolic acid;   N(10)-formyl-THF;   N(10)-formyltetrahydrofolic acid;   N-(10-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid;   N-(4-{[(2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl](formyl)amino}benzoyl)-L-glutamic acid
 alt_id: CHEBI:11304;   CHEBI:19108;   CHEBI:19109;   CHEBI:698
 xref: Beilstein:101559;   CAS:2800-34-2;   HMDB:HMDB0000972;   KNApSAcK:C00007251
 xref_mesh: MESH:C010161
 xref: foodb.food:FDB022345;   kegg.compound:C00234;   pubmed:1095054;   pubmed:13336106;   pubmed:13672973;   pubmed:9833324
 chemrof_inchikey: AUFGTPPARQZWDO-YUZLPWPTSA-N
 chemrof_formula: C20H23N7O7
 chemrof_inchi: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/t11?,13-/m0/s1
 chemrof_smiles: [H]C(=O)N(CC1CNc2nc(N)nc(=O)c2N1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1
 cyclic_relationship: is_conjugate_acid_of CHEBI:57454


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10-formyltetrahydrofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 increases metabolic processing ISO ALDH1L2 protein results in increased metabolism of 10-formyltetrahydropteroylglutamic acid CTD PMID:21238436 NCBI chr 7:22,141,872...22,193,403
Ensembl chr 7:22,141,842...22,193,398 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        biochemical role 19888
          metabolite 19624
            prokaryotic metabolite 17258
              bacterial metabolite 17258
                Escherichia coli metabolite 17053
                  10-formyltetrahydrofolic acid 1
                    (6R)-10-formyltetrahydrofolic acid 0
                    (6S)-10-formyltetrahydrofolic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic heterocyclic compound 19381
                                  organic heteropolycyclic compound 18616
                                    organic heterobicyclic compound 17442
                                      pteridines 10290
                                        pterins 9446
                                          folic acids 9443
                                            tetrahydrofolic acid 69
                                              formyltetrahydrofolic acid 61
                                                10-formyltetrahydrofolic acid 1
                                                  (6R)-10-formyltetrahydrofolic acid 0
                                                  (6S)-10-formyltetrahydrofolic acid 0
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